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Aliases for KANSL3 Gene

Aliases for KANSL3 Gene

  • KAT8 Regulatory NSL Complex Subunit 3 2 3 5
  • KIAA1310 2 3 4
  • Serum Inhibited-Related Protein 3 4
  • Testis Development Protein PRTD 3 4
  • Non-Specific Lethal 3 Homolog 3 4
  • NSL Complex Protein NSL3 3 4
  • NSL3 3 4
  • RCD1 3
  • PRTD 4
  • SI1 4

External Ids for KANSL3 Gene

Previous HGNC Symbols for KANSL3 Gene

  • KIAA1310

Previous GeneCards Identifiers for KANSL3 Gene

  • GC02M097259

Summaries for KANSL3 Gene

GeneCards Summary for KANSL3 Gene

KANSL3 (KAT8 Regulatory NSL Complex Subunit 3) is a Protein Coding gene. Diseases associated with KANSL3 include calcific tendinitis. Among its related pathways are Chromatin organization. GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot for KANSL3 Gene

  • As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Gene Wiki entry for KANSL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL3 Gene

Genomics for KANSL3 Gene

Regulatory Elements for KANSL3 Gene

Promoters for KANSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KANSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KANSL3 Gene

Chromosome:
2
Start:
96,593,155 bp from pter
End:
96,642,787 bp from pter
Size:
49,633 bases
Orientation:
Minus strand

Genomic View for KANSL3 Gene

Genes around KANSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL3 Gene

Proteins for KANSL3 Gene

  • Protein details for KANSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N6-KANL3_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 3
    Protein Accession:
    Q9P2N6
    Secondary Accessions:
    • A1L184
    • D3DXH3
    • D3DXH4
    • Q05BU4
    • Q6P3X2
    • Q6PJH6
    • Q86T19
    • Q96L64
    • Q9H0C9
    • Q9H8C9
    • Q9HAP8
    • Q9NWE5

    Protein attributes for KANSL3 Gene

    Size:
    904 amino acids
    Molecular mass:
    95992 Da
    Quaternary structure:
    • Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAH15469.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI27821.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=BAA92548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KANSL3 Gene

neXtProt entry for KANSL3 Gene

Proteomics data for KANSL3 Gene at MOPED

Post-translational modifications for KANSL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL3 Gene

Domains & Families for KANSL3 Gene

Protein Domains for KANSL3 Gene

Suggested Antigen Peptide Sequences for KANSL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KANSL3 Gene

Function for KANSL3 Gene

Molecular function for KANSL3 Gene

UniProtKB/Swiss-Prot Function:
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
genes like me logo Genes that share phenotypes with KANSL3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL3 Gene

Localization for KANSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANSL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANSL3 Gene COMPARTMENTS Subcellular localization image for KANSL3 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KANSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
genes like me logo Genes that share ontologies with KANSL3: view

Pathways & Interactions for KANSL3 Gene

genes like me logo Genes that share pathways with KANSL3: view

Pathways by source for KANSL3 Gene

Gene Ontology (GO) - Biological Process for KANSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043982 histone H4-K8 acetylation IDA 20018852
genes like me logo Genes that share ontologies with KANSL3: view

No data available for SIGNOR curated interactions for KANSL3 Gene

Drugs & Compounds for KANSL3 Gene

No Compound Related Data Available

Transcripts for KANSL3 Gene

Unigene Clusters for KANSL3 Gene

KAT8 regulatory NSL complex subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16:
SP17: - - - -
SP18: - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:

ExUns: 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - -
SP24:

Relevant External Links for KANSL3 Gene

GeneLoc Exon Structure for
KANSL3
ECgene alternative splicing isoforms for
KANSL3

Expression for KANSL3 Gene

mRNA expression in normal human tissues for KANSL3 Gene

Protein differential expression in normal tissues from HIPED for KANSL3 Gene

This gene is overexpressed in Liver, secretome (27.6), Peripheral blood mononuclear cells (19.3), and CD8 Tcells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KANSL3 Gene



SOURCE GeneReport for Unigene cluster for KANSL3 Gene Hs.516341

genes like me logo Genes that share expression patterns with KANSL3: view

Protein tissue co-expression partners for KANSL3 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KANSL3 Gene

Orthologs for KANSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia KANSL3 35
  • 93.01 (n)
  • 97.61 (a)
KANSL3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kansl3 35
  • 89.36 (n)
  • 94.53 (a)
Kansl3 16
Kansl3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KANSL3 35
  • 99.81 (n)
  • 100 (a)
KANSL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kansl3 35
  • 89.81 (n)
  • 94.87 (a)
cow
(Bos Taurus)
Mammalia KANSL3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANSL3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves KANSL3 35
  • 75.64 (n)
  • 80.37 (a)
KANSL3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158552 35
  • 69.86 (n)
  • 76.17 (a)
zebrafish
(Danio rerio)
Actinopterygii kansl3 35
  • 67.73 (n)
  • 69.97 (a)
kansl3 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rcd1 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54D11.2 36
  • 9 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for KANSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KANSL3 Gene

ENSEMBL:
Gene Tree for KANSL3 (if available)
TreeFam:
Gene Tree for KANSL3 (if available)

Paralogs for KANSL3 Gene

No data available for Paralogs for KANSL3 Gene

Variants for KANSL3 Gene

Sequence variations from dbSNP and Humsavar for KANSL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34406082 - 96,604,358(-) GTGGA(A/G)TCTCA nc-transcript-variant, reference, missense
rs2276652 -- 96,611,045(-) AAAGC(A/T)GAGTG intron-variant
rs3795992 -- 96,609,520(+) ACCAT(A/G)CTCTG nc-transcript-variant, reference, synonymous-codon
rs4907199 -- 96,614,679(+) ggtcc(A/G)agaat intron-variant
rs4907242 -- 96,607,376(+) TAAAG(A/C)TGCTA intron-variant

Variation tolerance for KANSL3 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANSL3 Gene

HapMap Linkage Disequilibrium report
KANSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KANSL3 Gene

Disorders for KANSL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KANSL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
calcific tendinitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for KANSL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KANSL3
genes like me logo Genes that share disorders with KANSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KANSL3 Gene

Publications for KANSL3 Gene

  1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y. … Conaway R.C. (J. Biol. Chem. 2010) 3 4 67
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  3. Males absent on the first (MOF): from flies to humans. (PMID: 17694080) Rea S. … Akhtar A. (Oncogene 2007) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for KANSL3 Gene

Sources for KANSL3 Gene

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