Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KANSL3 Gene

Aliases for KANSL3 Gene

  • KAT8 Regulatory NSL Complex Subunit 3 2 3
  • KIAA1310 2 3 4
  • Serum Inhibited-Related Protein 3 4
  • Testis Development Protein PRTD 3 4
  • Non-Specific Lethal 3 Homolog 3 4
  • NSL Complex Protein NSL3 3 4
  • NSL3 3 4
  • RCD1 3
  • PRTD 4
  • SI1 4

External Ids for KANSL3 Gene

Previous HGNC Symbols for KANSL3 Gene

  • KIAA1310

Previous GeneCards Identifiers for KANSL3 Gene

  • GC02M097259

Summaries for KANSL3 Gene

GeneCards Summary for KANSL3 Gene

KANSL3 (KAT8 Regulatory NSL Complex Subunit 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific).

UniProtKB/Swiss-Prot for KANSL3 Gene

  • As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Gene Wiki entry for KANSL3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL3 Gene

Genomics for KANSL3 Gene

Genomic Location for KANSL3 Gene

Start:
96,593,155 bp from pter
End:
96,642,787 bp from pter
Size:
49,633 bases
Orientation:
Minus strand

Genomic View for KANSL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KANSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL3 Gene

No data available for Regulatory Elements for KANSL3 Gene

Proteins for KANSL3 Gene

  • Protein details for KANSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2N6-KANL3_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 3
    Protein Accession:
    Q9P2N6
    Secondary Accessions:
    • A1L184
    • D3DXH3
    • D3DXH4
    • Q05BU4
    • Q6P3X2
    • Q6PJH6
    • Q86T19
    • Q96L64
    • Q9H0C9
    • Q9H8C9
    • Q9HAP8
    • Q9NWE5

    Protein attributes for KANSL3 Gene

    Size:
    904 amino acids
    Molecular mass:
    95992 Da
    Quaternary structure:
    • Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAH15469.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI27821.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part.; Evidence={ECO:0000305}; Sequence=BAA92548.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KANSL3 Gene

neXtProt entry for KANSL3 Gene

Proteomics data for KANSL3 Gene at MOPED

Post-translational modifications for KANSL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL3 Gene

Domains for KANSL3 Gene

Protein Domains for KANSL3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KANSL3 Gene

Function for KANSL3 Gene

Molecular function for KANSL3 Gene

UniProtKB/Swiss-Prot Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Gene Ontology (GO) - Molecular Function for KANSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IDA 20018852
GO:0046972 contributes_to histone acetyltransferase activity (H4-K16 specific) IDA 20018852
genes like me logo Genes that share ontologies with KANSL3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KANSL3 Gene

Localization for KANSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANSL3 Gene

Gene Ontology (GO) - Cellular Components for KANSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with KANSL3: view

No data available for Subcellular locations from COMPARTMENTS for KANSL3 Gene

Pathways for KANSL3 Gene

genes like me logo Genes that share pathways with KANSL3: view

Pathways by source for KANSL3 Gene

Gene Ontology (GO) - Biological Process for KANSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0043981 histone H4-K5 acetylation IDA 20018852
GO:0043982 histone H4-K8 acetylation IDA 20018852
GO:0043984 histone H4-K16 acetylation IDA 20018852
genes like me logo Genes that share ontologies with KANSL3: view

Transcripts for KANSL3 Gene

Unigene Clusters for KANSL3 Gene

KAT8 regulatory NSL complex subunit 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7: - - - - - - - - - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - -
SP13: - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16:
SP17: - - - -
SP18: - - - - - - - - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - -
SP21: - - - -
SP22:
SP23:
SP24:

ExUns: 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23: - -
SP24:

Relevant External Links for KANSL3 Gene

GeneLoc Exon Structure for
KANSL3
ECgene alternative splicing isoforms for
KANSL3

Expression for KANSL3 Gene

mRNA expression in normal human tissues for KANSL3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KANSL3 Gene

SOURCE GeneReport for Unigene cluster for KANSL3 Gene Hs.516341

genes like me logo Genes that share expressions with KANSL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KANSL3 Gene

Orthologs for KANSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANSL3 35
  • 99.81 (n)
  • 100 (a)
KANSL3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KANSL3 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANSL3 35
  • 93.01 (n)
  • 97.61 (a)
KANSL3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kansl3 35
  • 89.36 (n)
  • 94.53 (a)
Kansl3 16
Kansl3 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANSL3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
-- 36
  • 83 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Kansl3 35
  • 89.81 (n)
  • 94.87 (a)
chicken
(Gallus gallus)
Aves KANSL3 35
  • 75.64 (n)
  • 80.37 (a)
KANSL3 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100158552 35
  • 69.86 (n)
  • 76.17 (a)
zebrafish
(Danio rerio)
Actinopterygii kansl3 35
  • 67.73 (n)
  • 69.97 (a)
kansl3 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rcd1 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F54D11.2 36
  • 9 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for KANSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KANSL3 Gene

ENSEMBL:
Gene Tree for KANSL3 (if available)
TreeFam:
Gene Tree for KANSL3 (if available)

Paralogs for KANSL3 Gene

No data available for Paralogs for KANSL3 Gene

Variants for KANSL3 Gene

Sequence variations from dbSNP and Humsavar for KANSL3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs2276652 -- 96,611,045(-) AAAGC(A/T)GAGTG intron-variant
rs3795992 -- 96,609,520(+) ACCAT(A/G)CTCTG reference, synonymous-codon, nc-transcript-variant
rs4907199 -- 96,614,679(+) ggtcc(A/G)agaat intron-variant
rs4907242 -- 96,607,376(+) TAAAG(A/C)TGCTA intron-variant
rs4907243 -- 96,614,081(+) TTTTC(C/G)AATAT intron-variant

Relevant External Links for KANSL3 Gene

HapMap Linkage Disequilibrium report
KANSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KANSL3 Gene

Disorders for KANSL3 Gene

No disorders were found for KANSL3 Gene.

No data available for UniProtKB/Swiss-Prot for KANSL3 Gene

Publications for KANSL3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y. … Conaway R.C. (J. Biol. Chem. 2010) 3 4
  5. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PMID: 16543150) Mendjan S. … Akhtar A. (Mol. Cell 2006) 3 4

Products for KANSL3 Gene

Sources for KANSL3 Gene

Back to Top

Content