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Aliases for KANSL2 Gene

Aliases for KANSL2 Gene

  • KAT8 Regulatory NSL Complex Subunit 2 2 3 5
  • Non-Specific Lethal 2 Homolog 3 4
  • NSL Complex Protein NSL2 3 4
  • C12orf41 3 4
  • NSL2 3 4
  • Chromosome 12 Open Reading Frame 41 2

External Ids for KANSL2 Gene

Previous HGNC Symbols for KANSL2 Gene

  • C12orf41

Previous GeneCards Identifiers for KANSL2 Gene

  • GC12M049056
  • GC12M049062
  • GC12M049069
  • GC12M049080
  • GC12M049092

Summaries for KANSL2 Gene

GeneCards Summary for KANSL2 Gene

KANSL2 (KAT8 Regulatory NSL Complex Subunit 2) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include histone acetyltransferase activity (H4-K5 specific) and histone acetyltransferase activity (H4-K16 specific). An important paralog of this gene is INO80D.

UniProtKB/Swiss-Prot for KANSL2 Gene

  • As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Gene Wiki entry for KANSL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL2 Gene

Genomics for KANSL2 Gene

Regulatory Elements for KANSL2 Gene

Promoters for KANSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KANSL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for KANSL2 Gene

Chromosome:
12
Start:
48,653,211 bp from pter
End:
48,682,252 bp from pter
Size:
29,042 bases
Orientation:
Minus strand

Genomic View for KANSL2 Gene

Genes around KANSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL2 Gene

Proteins for KANSL2 Gene

  • Protein details for KANSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L4-KANL2_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 2
    Protein Accession:
    Q9H9L4
    Secondary Accessions:
    • Q8N3B5
    • Q96CV0
    • Q9NX51

    Protein attributes for KANSL2 Gene

    Size:
    492 amino acids
    Molecular mass:
    55042 Da
    Quaternary structure:
    • Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
    SequenceCaution:
    • Sequence=AAH09746.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13900.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91169.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAB14211.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39126.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KANSL2 Gene

    Alternative splice isoforms for KANSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANSL2 Gene

Proteomics data for KANSL2 Gene at MOPED

Post-translational modifications for KANSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for KANSL2 Gene

Domains & Families for KANSL2 Gene

Protein Domains for KANSL2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for KANSL2 Gene

Function for KANSL2 Gene

Molecular function for KANSL2 Gene

UniProtKB/Swiss-Prot Function:
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.

Animal Model Products

miRNA for KANSL2 Gene

miRTarBase miRNAs that target KANSL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL2 Gene

Localization for KANSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANSL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANSL2 Gene COMPARTMENTS Subcellular localization image for KANSL2 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
cytoskeleton 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for KANSL2 Gene

Pathways & Interactions for KANSL2 Gene

genes like me logo Genes that share pathways with KANSL2: view

Pathways by source for KANSL2 Gene

Gene Ontology (GO) - Biological Process for KANSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043982 histone H4-K8 acetylation IDA 20018852
genes like me logo Genes that share ontologies with KANSL2: view

No data available for SIGNOR curated interactions for KANSL2 Gene

Drugs & Compounds for KANSL2 Gene

No Compound Related Data Available

Transcripts for KANSL2 Gene

mRNA/cDNA for KANSL2 Gene

Unigene Clusters for KANSL2 Gene

KAT8 regulatory NSL complex subunit 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: - -
SP8: -
SP9: - - - -
SP10: -
SP11:

ExUns: 15f
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for KANSL2 Gene

GeneLoc Exon Structure for
KANSL2
ECgene alternative splicing isoforms for
KANSL2

Expression for KANSL2 Gene

mRNA expression in normal human tissues for KANSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KANSL2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (47.2), CD8 Tcells (7.0), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KANSL2 Gene



SOURCE GeneReport for Unigene cluster for KANSL2 Gene Hs.505412

genes like me logo Genes that share expression patterns with KANSL2: view

Protein tissue co-expression partners for KANSL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KANSL2 Gene

Orthologs for KANSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANSL2 36
  • 100 (a)
OneToOne
KANSL2 35
  • 99.59 (n)
  • 99.8 (a)
cow
(Bos Taurus)
Mammalia KANSL2 35
  • 93.81 (n)
  • 96.72 (a)
KANSL2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANSL2 36
  • 96 (a)
OneToOne
KANSL2 35
  • 94.44 (n)
  • 95.52 (a)
mouse
(Mus musculus)
Mammalia Kansl2 16
Kansl2 36
  • 95 (a)
OneToOne
Kansl2 35
  • 89.64 (n)
  • 95.68 (a)
oppossum
(Monodelphis domestica)
Mammalia KANSL2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANSL2 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kansl2 35
  • 89.89 (n)
  • 94.67 (a)
chicken
(Gallus gallus)
Aves KANSL2 35
  • 75.28 (n)
  • 86.41 (a)
KANSL2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia flj20436-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia kansl2 35
  • 68.63 (n)
  • 71.95 (a)
Str.15082 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9143 35
zebrafish
(Danio rerio)
Actinopterygii kansl2 35
  • 68.47 (n)
  • 71.43 (a)
wufb75c02 35
kansl2 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006680 35
  • 48.54 (n)
  • 43.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta dgt1 35
  • 47.57 (n)
  • 42.41 (a)
dgt1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for KANSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KANSL2 Gene

ENSEMBL:
Gene Tree for KANSL2 (if available)
TreeFam:
Gene Tree for KANSL2 (if available)

Paralogs for KANSL2 Gene

Paralogs for KANSL2 Gene

Pseudogenes.org Pseudogenes for KANSL2 Gene

genes like me logo Genes that share paralogs with KANSL2: view

Variants for KANSL2 Gene

Sequence variations from dbSNP and Humsavar for KANSL2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_030767 -
VAR_030768 -
rs1895994 -- 48,662,880(+) TGCTC(A/G)CCTTA intron-variant
rs2409084 -- 48,663,004(-) CTGTA(C/T)GGTGT intron-variant
rs2277365 -- 48,682,028(+) TGTCC(G/T)ACGGC intron-variant

Variation tolerance for KANSL2 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANSL2 Gene

HapMap Linkage Disequilibrium report
KANSL2
Human Gene Mutation Database (HGMD)
KANSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KANSL2 Gene

Disorders for KANSL2 Gene

Relevant External Links for KANSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KANSL2

No disorders were found for KANSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANSL2 Gene

Publications for KANSL2 Gene

  1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y. … Conaway R.C. (J. Biol. Chem. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein J.I. … Sullivan P.F. (Nat Commun 2014) 3
  4. Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. (PMID: 24788516) Dias J. … Akhtar A. (Genes Dev. 2014) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for KANSL2 Gene

Sources for KANSL2 Gene

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