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Aliases for KANSL1L Gene

Aliases for KANSL1L Gene

  • KAT8 Regulatory NSL Complex Subunit 1 Like 2 3 5
  • C2orf67 3 4
  • MSL1v2 3 4
  • KAT8 Regulatory NSL Complex Subunit 1-Like Protein 3
  • KAT8 Regulatory NSL Complex Subunit 1-Like 2
  • Chromosome 2 Open Reading Frame 67 2
  • Male-Specific Lethal 1 Homolog 3
  • KIAA1267-Like 2

External Ids for KANSL1L Gene

Previous HGNC Symbols for KANSL1L Gene

  • C2orf67

Previous GeneCards Identifiers for KANSL1L Gene

  • GC02M210886

Summaries for KANSL1L Gene

GeneCards Summary for KANSL1L Gene

KANSL1L (KAT8 Regulatory NSL Complex Subunit 1 Like) is a Protein Coding gene. An important paralog of this gene is KANSL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL1L Gene

Genomics for KANSL1L Gene

Regulatory Elements for KANSL1L Gene

Enhancers for KANSL1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F210195 0.4 Ensembl 16.8 -24.0 -24025 0.8 SCRT1 ELF3 CTCF ZNF654 NFIA TRIM22 REST RAD21 ZGPAT SCRT2 KANSL1L RPE ENSG00000231294 ACADL
GH02F210007 1.8 FANTOM5 Ensembl ENCODE 14 +163.3 163304 0.6 PKNOX1 PBX2 FOS SPI1 KANSL1L ENSG00000231294 RPE GC02M209962
GH02F210001 0.2 ENCODE 10.4 +167.9 167932 3.8 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 LOC101928020 ENSG00000231294 KANSL1L RPE MAP2 GC02M209962
GH02F210168 0.5 ENCODE 6.1 +1.0 1028 5.0 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 SP5 NFYC JUNB KANSL1L MAP2 GC02M210099
GH02F210070 0.3 FANTOM5 1.3 +100.3 100327 0.3 ACADL KANSL1L GC02P210074 LOC101928020
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KANSL1L on UCSC Golden Path with GeneCards custom track

Promoters for KANSL1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000606578 683 4201 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 SP3 SP5 NFYC

Genomic Location for KANSL1L Gene

Chromosome:
2
Start:
210,020,711 bp from pter
End:
210,171,383 bp from pter
Size:
150,673 bases
Orientation:
Minus strand

Genomic View for KANSL1L Gene

Genes around KANSL1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL1L Gene

Proteins for KANSL1L Gene

  • Protein details for KANSL1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AUZ9-KAL1L_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 1-like protein
    Protein Accession:
    A0AUZ9
    Secondary Accessions:
    • B7ZLN1
    • I6L9A8
    • Q53TV8
    • Q53TW3
    • Q6IS05
    • Q8TCI1
    • Q96MI0
    • Q9UFC3

    Protein attributes for KANSL1L Gene

    Size:
    987 amino acids
    Molecular mass:
    112253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85085.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Erroneous termination; Positions=914; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Frameshift; Positions=496, 502, 550, 553, 673, 676, 755, 757, 853; Evidence={ECO:0000305};

    Alternative splice isoforms for KANSL1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANSL1L Gene

Post-translational modifications for KANSL1L Gene

  • Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL1L Gene

Domains & Families for KANSL1L Gene

Protein Domains for KANSL1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KANSL1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KANSL1L Gene

Function for KANSL1L Gene

Gene Ontology (GO) - Molecular Function for KANSL1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001047 core promoter binding IBA --
GO:0035035 histone acetyltransferase binding IBA --
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IBA --
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IBA --
GO:0046972 contributes_to histone acetyltransferase activity (H4-K16 specific) IBA --
genes like me logo Genes that share ontologies with KANSL1L: view

Phenotypes for KANSL1L Gene

genes like me logo Genes that share phenotypes with KANSL1L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL1L Gene

Localization for KANSL1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANSL1L Gene COMPARTMENTS Subcellular localization image for KANSL1L gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for KANSL1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044545 NSL complex IBA --
genes like me logo Genes that share ontologies with KANSL1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KANSL1L Gene

Pathways & Interactions for KANSL1L Gene

SuperPathways for KANSL1L Gene

No Data Available

Interacting Proteins for KANSL1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281772%0d%0a9606.ENSP00000263036%0d%0a
Selected Interacting proteins: A0AUZ9-KAL1L_HUMAN ENSP00000281772 for KANSL1L Gene via IID STRING

Gene Ontology (GO) - Biological Process for KANSL1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043981 histone H4-K5 acetylation IEA --
GO:0043982 histone H4-K8 acetylation IEA --
GO:0043984 histone H4-K16 acetylation IEA --
genes like me logo Genes that share ontologies with KANSL1L: view

No data available for Pathways by source and SIGNOR curated interactions for KANSL1L Gene

Transcripts for KANSL1L Gene

Unigene Clusters for KANSL1L Gene

KAT8 regulatory NSL complex subunit 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL1L Gene

No ASD Table

Relevant External Links for KANSL1L Gene

GeneLoc Exon Structure for
KANSL1L
ECgene alternative splicing isoforms for
KANSL1L

Expression for KANSL1L Gene

mRNA expression in normal human tissues for KANSL1L Gene

Protein differential expression in normal tissues from HIPED for KANSL1L Gene

This gene is overexpressed in Platelet (35.2), Urine (23.5), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KANSL1L Gene



NURSA nuclear receptor signaling pathways regulating expression of KANSL1L Gene:

KANSL1L

SOURCE GeneReport for Unigene cluster for KANSL1L Gene:

Hs.591638
genes like me logo Genes that share expression patterns with KANSL1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for KANSL1L Gene

Orthologs for KANSL1L Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANSL1L 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia KANSL1L 34 35
  • 91.19 (n)
cow
(Bos Taurus)
Mammalia KANSL1L 34 35
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Kansl1l 34 16 35
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Kansl1l 34
  • 86.07 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7339 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANSL1L 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7H2ORF67 34
  • 66.26 (n)
KANSL1L 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL1L 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kansl1l 34
  • 51.08 (n)
zebrafish
(Danio rerio)
Actinopterygii kansl1l 34 35
  • 46.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta wah 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 14 (a)
OneToMany
Species where no ortholog for KANSL1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KANSL1L Gene

ENSEMBL:
Gene Tree for KANSL1L (if available)
TreeFam:
Gene Tree for KANSL1L (if available)

Paralogs for KANSL1L Gene

Paralogs for KANSL1L Gene

(2) SIMAP similar genes for KANSL1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KANSL1L: view

Variants for KANSL1L Gene

Sequence variations from dbSNP and Humsavar for KANSL1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10048697 -- 210,114,731(+) aaaat(A/G)attat intron-variant
rs10048758 -- 210,116,647(+) aggtc(A/G)tacct intron-variant
rs10166394 -- 210,141,195(+) ttctC(C/T)ttttc intron-variant, upstream-variant-2KB
rs10167148 -- 210,080,031(+) TGAAA(C/G)TGGTC intron-variant, utr-variant-5-prime
rs10173414 -- 210,027,440(+) TGTTT(C/T)CTTGG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KANSL1L Gene

Variant ID Type Subtype PubMed ID
esv2667293 CNV deletion 23128226
esv3594154 CNV loss 21293372

Variation tolerance for KANSL1L Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANSL1L Gene

Human Gene Mutation Database (HGMD)
KANSL1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KANSL1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANSL1L Gene

Disorders for KANSL1L Gene

Relevant External Links for KANSL1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KANSL1L

No disorders were found for KANSL1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANSL1L Gene

Publications for KANSL1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. DNA damage induced MutS homologue hMSH4 acetylation. (PMID: 24145748) Chu Y.L. … Her C. (Int. J. Mol. Sci. 2013) 4 64
  4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for KANSL1L Gene

Sources for KANSL1L Gene

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