KANSL1L Gene
protein-coding GIFtS: 41
GCID: GC02M210886
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KAT8 regulatory NSL complex subunit 1-like(Previous name: chromosome 2 open reading frame 67 )
(Previous symbol: C2orf67)
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Aliases
for KANSL1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| KAT8 Regulatory NSL Complex Subunit 1-Like1 2 | | KIAA1267L1 | | C2orf671 2 3 | | Chromosome 2 Open Reading Frame 671 | | MSL1v21 2 3 | | KAT8 Regulatory NSL Complex Subunit 1-Like Protein2 | | FLJ238611 | | Male-Specific Lethal 1 Homolog2 | | FLJ323491 | | |
Export aliases for KANSL1L gene to outside databases |
Summaries
for KANSL1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for KANSL1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KANSL1L
Other transcription factors
Search SABiosciences Chromatin IP Primers for KANSL1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KANSL1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q34 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q34KANSL1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M210886: view genomic region
(about GC identifiers)
Start:
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210,885,435 bp from pter |
End:
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211,036,107 bp from pter |
Size:
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150,673 bases |
Orientation:
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minus strand |
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Proteins
for KANSL1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KAL1L_HUMAN, A0AUZ9 (See
protein sequence)Recommended Name: KAT8 regulatory NSL complex subunit 1-like protein Size: 987 amino acids; 112253 Da
Sequence caution: Sequence=BAB85085.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAB85085.1; Type=Erroneous termination; Positions=914; Note=Translated as Trp; Sequence=BAB85085.1;Type=Frameshift; Positions=496, 502, 550, 553, 673, 676, 755, 757, 853;
Secondary accessions: B7ZLN1 Q53TV8 Q53TW3 Q6IS05 Q8TCI1 Q96MI0 Q9UFC3Alternative splicing: 4 isoforms: A0AUZ9-1 A0AUZ9-2 A0AUZ9-3 A0AUZ9-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for KANSL1L: NX_A0AUZ9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A0AUZ9
KANSL1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689732.2
ENSEMBL proteins: ENSP00000281772 ENSP00000405724 ENSP00000393432 ENSP00000401408 ENSP00000402261 ENSP00000407495 ENSP00000388182
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000123 | histone acetyltransferase complex |
IEA | -- |
KANSL1L for ontologies About GeneDecksing
KANSL1L Antibody Products:
Assay Products for KANSL1L: |
Protein
Domains /
Families
for KANSL1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KANSL1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A0AUZ9ProtoNet protein and cluster: A0AUZ9 |
Function
for KANSL1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KANSL1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KANSL1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KANSL1L |
|
Pathways & Interactions
for KANSL1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KANSL1L
1 Interacting protein for KANSL1L (A0AUZ93) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KANSL1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KANSL1L
Search CenterWatch for drugs/clinical trials and news about KANSL1L / KAL1L
|
Transcripts
for KANSL1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KANSL1L gene: NM_152519.2 Unigene Cluster for KANSL1L: KAT8 regulatory NSL complex subunit 1-like Hs.591638 [show with all ESTs]Unigene Representative Sequence: NM_15251910 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281772(uc002vds.3 uc002vdt.3) ENST00000418791 ENST00000457374(uc002vdx.1 uc002vdv.3)
ENST00000452086(uc002vdw.3) ENST00000428655 ENST00000460256 ENST00000438563
ENST00000415553 ENST00000453904(uc002vdy.1) ENST00000429908
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KANSL1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KANSL1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for KANSL1L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KANSL1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KANSL1L |
Additional cDNA sequence: AB075523.1 AK055724.1 AK056911.1 AK057810.1 AK074441.1 AK308432.1 BC032837.1 BC070141.1 BC090854.1 BC126155.1 BC143914.1 13 DOTS entries: DT.100790621 DT.97845556 DT.92439316 DT.70103209 DT.40119832 DT.100746820 DT.65284029 DT.92016065 DT.405995 DT.97786905 DT.95240526 DT.120956787 DT.205778 24/89 AceView cDNA sequences (see all 89): BX451066 AA913050 Z39866 NM_152519 BE897311 AA290631 AW196977 BF108694 AK124963 CB140107 AA252480 AI524515 AA279856 AA828392 CD557482 BX376230 BC032837 CR616459 AA827777 AI050936 AW294333 AI375748 CA393360 AA291038
GeneLoc Exon Structure
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Expression
for KANSL1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KANSL1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAAAAAGGT
About this image
See KANSL1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KANSL1L
SOURCE GeneReport for Unigene cluster: Hs.591638
SABiosciences Custom PCR Arrays for KANSL1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KANSL1L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat KANSL1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KANSL1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KANSL1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KANSL1L |
Orthologs
for KANSL1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for KANSL1L gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
KANSL1L1 |
KAT8 regulatory NSL complex subunit 1-like |
66.46(n)
55.66(a) |
|
424004 XM_421860.3 XP_421860.3 |
lizard
(Anolis carolinensis) |
Reptilia |
C2orf676 |
-- |
48(a) |
1 ↔ 1 |
1(113358961-113391098) |
zebrafish
(Danio rerio) |
Actinopterygii |
kansl1l1 |
KAT8 regulatory NSL complex subunit 1-like |
45.85(n)
35.89(a) |
|
561374 XM_684784.4 XP_689876.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
wah6 |
waharan |
10(a) |
1 → many |
3R(11619498-11627647) |
ENSEMBL Gene Tree for KANSL1L (if available)
TreeFam Gene Tree for KANSL1L (if available) |
Paralogs
for KANSL1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KANSL1L gene
- KANSL12
2 SIMAP similar genes for KANSL1L using alignment to 4 protein entries: KAL1L_HUMAN (see all proteins):C2orf67 KANSL1
KANSL1L for paralogs About GeneDecksing
|
Genomic Variants
for KANSL1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KANSL1L (210885435 - 211036107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KANSL1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KANSL1L |
|
Disorders
/ Diseases
for KANSL1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KANSL1L for disorders About GeneDecksing
OMIM gene information: 613833
OMIM disorders: --
1  disease for KANSL1L: About MalaCardschoroiditis
Export disorders for KANSL1L gene to outside databases
|
Publications
for KANSL1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KANSL1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with KANSL1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1 Smith E.R.... Lucchesi J.C. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410)1 Wistow G.... Peterson K. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for KANSL1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KANSL1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KANSL1L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing KANSL1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KANSL1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KANSL1L gene:
Search GeneIP for patents involving KANSL1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KANSL1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for KANSL1L | | OriGene Custom Protein Services for KANSL1L | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KANSL1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KANSL1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KANSL1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KANSL1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KANSL1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KANSL1L |
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| |  |  |  |  | | | | |
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 | | | KANSL1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KANSL1L |
|  |  |  | | | | Search ThermoFisher Antibodies for KANSL1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KANSL1L |
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