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Aliases for KANSL1L Gene

Aliases for KANSL1L Gene

  • KAT8 Regulatory NSL Complex Subunit 1 Like 2 3 5
  • C2orf67 3 4
  • MSL1v2 3 4
  • KAT8 Regulatory NSL Complex Subunit 1-Like 2
  • Chromosome 2 Open Reading Frame 67 2
  • Male-Specific Lethal 1 Homolog 3
  • KIAA1267-Like 2

External Ids for KANSL1L Gene

Previous HGNC Symbols for KANSL1L Gene

  • C2orf67

Previous GeneCards Identifiers for KANSL1L Gene

  • GC02M210886

Summaries for KANSL1L Gene

GeneCards Summary for KANSL1L Gene

KANSL1L (KAT8 Regulatory NSL Complex Subunit 1 Like) is a Protein Coding gene. An important paralog of this gene is KANSL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL1L Gene

Genomics for KANSL1L Gene

Regulatory Elements for KANSL1L Gene

Enhancers for KANSL1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KANSL1L on UCSC Golden Path with GeneCards custom track

Promoters for KANSL1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KANSL1L on UCSC Golden Path with GeneCards custom track

Genomic Location for KANSL1L Gene

Chromosome:
2
Start:
210,020,711 bp from pter
End:
210,171,383 bp from pter
Size:
150,673 bases
Orientation:
Minus strand

Genomic View for KANSL1L Gene

Genes around KANSL1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL1L Gene

Proteins for KANSL1L Gene

  • Protein details for KANSL1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AUZ9-KAL1L_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 1-like protein
    Protein Accession:
    A0AUZ9
    Secondary Accessions:
    • B7ZLN1
    • I6L9A8
    • Q53TV8
    • Q53TW3
    • Q6IS05
    • Q8TCI1
    • Q96MI0
    • Q9UFC3

    Protein attributes for KANSL1L Gene

    Size:
    987 amino acids
    Molecular mass:
    112253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85085.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Erroneous termination; Positions=914; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Frameshift; Positions=496, 502, 550, 553, 673, 676, 755, 757, 853; Evidence={ECO:0000305};

    Alternative splice isoforms for KANSL1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANSL1L Gene

Proteomics data for KANSL1L Gene at MOPED

Post-translational modifications for KANSL1L Gene

  • Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL1L Gene

Domains & Families for KANSL1L Gene

Protein Domains for KANSL1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KANSL1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL1L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for KANSL1L Gene

Function for KANSL1L Gene

Phenotypes for KANSL1L Gene

genes like me logo Genes that share phenotypes with KANSL1L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL1L Gene

Localization for KANSL1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANSL1L Gene COMPARTMENTS Subcellular localization image for KANSL1L gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KANSL1L Gene

Pathways & Interactions for KANSL1L Gene

SuperPathways for KANSL1L Gene

No Data Available

Interacting Proteins for KANSL1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281772%0d%0a9606.ENSP00000263036%0d%0a
Selected Interacting proteins: ENSP00000281772 A0AUZ9-KAL1L_HUMAN for KANSL1L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for KANSL1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KANSL1L Gene

Drugs & Compounds for KANSL1L Gene

No Compound Related Data Available

Transcripts for KANSL1L Gene

Unigene Clusters for KANSL1L Gene

KAT8 regulatory NSL complex subunit 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL1L Gene

No ASD Table

Relevant External Links for KANSL1L Gene

GeneLoc Exon Structure for
KANSL1L
ECgene alternative splicing isoforms for
KANSL1L

Expression for KANSL1L Gene

mRNA expression in normal human tissues for KANSL1L Gene

Protein differential expression in normal tissues from HIPED for KANSL1L Gene

This gene is overexpressed in Platelet (35.2), Urine (23.5), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KANSL1L Gene



SOURCE GeneReport for Unigene cluster for KANSL1L Gene Hs.591638

genes like me logo Genes that share expression patterns with KANSL1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KANSL1L Gene

Orthologs for KANSL1L Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KANSL1L 35
  • 90.72 (n)
  • 88.19 (a)
KANSL1L 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANSL1L 35
  • 91.19 (n)
  • 87.54 (a)
KANSL1L 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kansl1l 35
  • 86.63 (n)
  • 81.26 (a)
Kansl1l 16
Kansl1l 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KANSL1L 35
  • 99.7 (n)
  • 99.8 (a)
KANSL1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kansl1l 35
  • 86.07 (n)
  • 80.83 (a)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7339 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANSL1L 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7H2ORF67 35
  • 66.26 (n)
  • 55.35 (a)
KANSL1L 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL1L 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kansl1l 35
  • 51.08 (n)
  • 39.79 (a)
zebrafish
(Danio rerio)
Actinopterygii kansl1l 35
  • 46.96 (n)
  • 36.53 (a)
kansl1l 36
  • 27 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta wah 36
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
OneToMany
Species with no ortholog for KANSL1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KANSL1L Gene

ENSEMBL:
Gene Tree for KANSL1L (if available)
TreeFam:
Gene Tree for KANSL1L (if available)

Paralogs for KANSL1L Gene

Paralogs for KANSL1L Gene

(2) SIMAP similar genes for KANSL1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KANSL1L: view

Variants for KANSL1L Gene

Sequence variations from dbSNP and Humsavar for KANSL1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1558551 -- 210,136,400(+) AAAAT(A/C)GTCTT intron-variant
rs2723206 -- 210,068,707(-) AAAGA(C/T)GAGAC intron-variant
rs2723207 -- 210,065,611(-) AAAAC(G/T)CTGTA intron-variant
rs2723208 -- 210,072,066(-) TATTG(A/G)TGGTA intron-variant
rs2887881 -- 210,146,262(+) CTACA(A/G)ATTCA intron-variant

Variation tolerance for KANSL1L Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANSL1L Gene

Human Gene Mutation Database (HGMD)
KANSL1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KANSL1L Gene

Disorders for KANSL1L Gene

Relevant External Links for KANSL1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KANSL1L

No disorders were found for KANSL1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANSL1L Gene

Publications for KANSL1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PMID: 16227571) Smith E.R. … Lucchesi J.C. (Mol. Cell. Biol. 2005) 3
  4. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for KANSL1L Gene

Sources for KANSL1L Gene

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