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Aliases for KANSL1L Gene

Aliases for KANSL1L Gene

  • KAT8 Regulatory NSL Complex Subunit 1 Like 2 3 5
  • C2orf67 3 4
  • MSL1v2 3 4
  • KAT8 Regulatory NSL Complex Subunit 1-Like Protein 3
  • KAT8 Regulatory NSL Complex Subunit 1-Like 2
  • Chromosome 2 Open Reading Frame 67 2
  • Male-Specific Lethal 1 Homolog 3
  • KIAA1267-Like 2

External Ids for KANSL1L Gene

Previous HGNC Symbols for KANSL1L Gene

  • C2orf67

Previous GeneCards Identifiers for KANSL1L Gene

  • GC02M210886

Summaries for KANSL1L Gene

GeneCards Summary for KANSL1L Gene

KANSL1L (KAT8 Regulatory NSL Complex Subunit 1 Like) is a Protein Coding gene. An important paralog of this gene is KANSL1.

Additional gene information for KANSL1L Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANSL1L Gene

Genomics for KANSL1L Gene

Regulatory Elements for KANSL1L Gene

Enhancers for KANSL1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H210007 0.8 FANTOM5 ENCODE 14 +163.2 163240 0 PKNOX1 FOS SPI1 KANSL1L RPE GC02M209962
GH02H210001 1 ENCODE 10.4 +167.9 167932 3 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 ELK1 ZNF143 KLF7 LOC101928020 KANSL1L RPE MAP2 GC02M209962
GH02H209639 0.6 ENCODE 14.1 +529.9 529877 3 JUN CEBPB EP300 ZNF148 JUND MAFF FOS NFE2 MAFK NFE2L2 KANSL1L LOC101928020 GC02P209686 GC02P209534
GH02H210195 0.7 Ensembl 11.8 -24.0 -24018 0 ELF3 SCRT1 CTCF ZNF654 NFIA TRIM22 REST RAD21 ZGPAT CEBPA RPE KANSL1L ACADL ENSG00000279317
GH02H210167 1.3 ENCODE dbSUPER 6.1 +1.0 1028 5 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK SP3 SP5 MXD4 KANSL1L MAP2 GC02M210099
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KANSL1L on UCSC Golden Path with GeneCards custom track

Promoters for KANSL1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000129633 483 3401 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS DEK SP3 SP5

Genomic Location for KANSL1L Gene

Chromosome:
2
Start:
210,020,711 bp from pter
End:
210,171,383 bp from pter
Size:
150,673 bases
Orientation:
Minus strand

Genomic View for KANSL1L Gene

Genes around KANSL1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANSL1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANSL1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANSL1L Gene

Proteins for KANSL1L Gene

  • Protein details for KANSL1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0AUZ9-KAL1L_HUMAN
    Recommended name:
    KAT8 regulatory NSL complex subunit 1-like protein
    Protein Accession:
    A0AUZ9
    Secondary Accessions:
    • B7ZLN1
    • I6L9A8
    • Q53TV8
    • Q53TW3
    • Q6IS05
    • Q8TCI1
    • Q96MI0
    • Q9UFC3

    Protein attributes for KANSL1L Gene

    Size:
    987 amino acids
    Molecular mass:
    112253 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85085.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Erroneous termination; Positions=914; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=BAB85085.1; Type=Frameshift; Positions=496, 502, 550, 553, 673, 676, 755, 757, 853; Evidence={ECO:0000305};

    Alternative splice isoforms for KANSL1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANSL1L Gene

Post-translational modifications for KANSL1L Gene

  • Acetylated on lysine residues by KAT8 upon ionizing radiation-induced DNA damage; deacetylated by HDAC3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KANSL1L Gene

Domains & Families for KANSL1L Gene

Gene Families for KANSL1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for KANSL1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KANSL1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KANSL1L: view

No data available for UniProtKB/Swiss-Prot for KANSL1L Gene

Function for KANSL1L Gene

Phenotypes From GWAS Catalog for KANSL1L Gene

Phenotypes for KANSL1L Gene

genes like me logo Genes that share phenotypes with KANSL1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KANSL1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANSL1L Gene

Localization for KANSL1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KANSL1L gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KANSL1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IEA --
genes like me logo Genes that share ontologies with KANSL1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KANSL1L Gene

Pathways & Interactions for KANSL1L Gene

SuperPathways for KANSL1L Gene

No Data Available

Interacting Proteins for KANSL1L Gene

Selected Interacting proteins: A0AUZ9-KAL1L_HUMAN for KANSL1L Gene via IID

Symbol External ID(s) Details
OPTN
RAC1

Gene Ontology (GO) - Biological Process for KANSL1L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KANSL1L Gene

Drugs & Compounds for KANSL1L Gene

No Compound Related Data Available

Transcripts for KANSL1L Gene

Unigene Clusters for KANSL1L Gene

KAT8 regulatory NSL complex subunit 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for KANSL1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KANSL1L Gene

No ASD Table

Relevant External Links for KANSL1L Gene

GeneLoc Exon Structure for
KANSL1L
ECgene alternative splicing isoforms for
KANSL1L

Expression for KANSL1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KANSL1L Gene

Protein differential expression in normal tissues from HIPED for KANSL1L Gene

This gene is overexpressed in Platelet (35.2), Urine (23.5), and Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KANSL1L Gene



NURSA nuclear receptor signaling pathways regulating expression of KANSL1L Gene:

KANSL1L

SOURCE GeneReport for Unigene cluster for KANSL1L Gene:

Hs.591638

Evidence on tissue expression from TISSUES for KANSL1L Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with KANSL1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KANSL1L Gene

Orthologs for KANSL1L Gene

This gene was present in the common ancestor of animals.

Orthologs for KANSL1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANSL1L 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia KANSL1L 33 34
  • 91.19 (n)
cow
(Bos Taurus)
Mammalia KANSL1L 33 34
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Kansl1l 33 16 34
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Kansl1l 33
  • 86.07 (n)
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7339 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANSL1L 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves C7H2ORF67 33
  • 66.26 (n)
KANSL1L 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANSL1L 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kansl1l 33
  • 51.08 (n)
zebrafish
(Danio rerio)
Actinopterygii kansl1l 33 34
  • 46.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta wah 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 14 (a)
OneToMany
Species where no ortholog for KANSL1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KANSL1L Gene

ENSEMBL:
Gene Tree for KANSL1L (if available)
TreeFam:
Gene Tree for KANSL1L (if available)

Paralogs for KANSL1L Gene

Paralogs for KANSL1L Gene

(2) SIMAP similar genes for KANSL1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with KANSL1L: view

Variants for KANSL1L Gene

Sequence variations from dbSNP and Humsavar for KANSL1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000005896 -- 210,085,716(+) ATTTT(C/T)CCACT intron-variant, downstream-variant-500B
rs1000020421 -- 210,026,817(+) CCAGG(C/T)TGGAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000021835 -- 210,172,320(+) GGAAC(A/G)AAGAG upstream-variant-2KB
rs1000023764 -- 210,034,668(+) TGTTG(A/G)ACTGT intron-variant
rs1000038238 -- 210,167,965(+) ACATT(C/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KANSL1L Gene

Variant ID Type Subtype PubMed ID
esv2667293 CNV deletion 23128226
esv3594154 CNV loss 21293372

Variation tolerance for KANSL1L Gene

Residual Variation Intolerance Score: 42.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANSL1L Gene

Human Gene Mutation Database (HGMD)
KANSL1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KANSL1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANSL1L Gene

Disorders for KANSL1L Gene

Relevant External Links for KANSL1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KANSL1L

No disorders were found for KANSL1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANSL1L Gene

Publications for KANSL1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. DNA damage induced MutS homologue hMSH4 acetylation. (PMID: 24145748) Chu YL … Her C (International journal of molecular sciences 2013) 4 60
  5. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C … Mann M (Science (New York, N.Y.) 2009) 4 60

Products for KANSL1L Gene

Sources for KANSL1L Gene

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