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KANSL1 Gene

protein-coding   GIFtS: 50
GCID: GC17M044108

KAT8 Regulatory NSL Complex Subunit 1

(Previous name: KIAA1267)
(Previous symbol: KIAA1267)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KAT8 Regulatory NSL Complex Subunit 11 2     MSL1 Homolog 12 3
KIAA12671 2 3 5     NSL Complex Protein NSL12 3
Centromere Protein 361 2     KDVS2 5
Non-Specific Lethal 1 Homolog2 3     MSL1V13 5
NSL12 3     CENP-362
hMSL1v12 3     MSL1v12
MLL1/MLL Complex Subunit KANSL12 3     Male-Specific Lethal 1 Homolog2

External Ids:    HGNC: 245651   Entrez Gene: 2840582   Ensembl: ENSG000001200717   OMIM: 6124525   UniProtKB: Q7Z3B33   

Export aliases for KANSL1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for KANSL1 Gene:
This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation,
the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine)
acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. (provided by RefSeq, Jun 2012)

GeneCards Summary for KANSL1 Gene:
KANSL1 (KAT8 regulatory NSL complex subunit 1) is a protein-coding gene. Diseases associated with KANSL1 include koolen-de vries syndrome, and kansl1-related intellectual disability syndrome. GO annotations related to this gene include histone acetyltransferase activity (H4-K16 specific) and histone acetyltransferase activity (H4-K5 specific). An important paralog of this gene is KANSL1L.

UniProtKB/Swiss-Prot: KANL1_HUMAN, Q7Z3B3
Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine
residues and therefore may be involved in the regulation of transcription

Gene Wiki entry for KANSL1 (KIAA1267) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NT_187663.1  NT_167251.2  NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for KANSL1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKANSL1 promoter sequence
   Search Chromatin IP Primers for KANSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KANSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

KANSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KANSL1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M044108:  view genomic region     (about GC identifiers)

Start:
44,107,282 bp from pter      End:
44,302,740 bp from pter
Size:
195,459 bases      Orientation:
minus strand

2 alternative locations:
Chr17+,NT_167251 563,498-759,135      Chr17+,ALT_REF_LOCI_9 44,001,606-44,145,324     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: KANL1_HUMAN, Q7Z3B3 (See protein sequence)
Recommended Name: KAT8 regulatory NSL complex subunit 1  
Size: 1105 amino acids; 121025 Da
Subunit: Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1,
WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX,
MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9
and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20,
OGT1/OGT, WDR5 and HCFC1. Interacts with KAT8; the interaction is direct
Sequence caution: Sequence=CAH10565.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5E4 Q6AW85 Q8IYH1 Q9BRH0 Q9NTE7 Q9UFT0 Q9ULF3
Alternative splicing: 2 isoforms:  Q7Z3B3-1   Q7Z3B3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KANSL1: NX_Q7Z3B3

Explore proteomics data for KANSL1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KANSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180394.1  NP_001180395.1  NP_056258.1  

    ENSEMBL proteins: 
     ENSP00000461812   ENSP00000461299   ENSP00000461484   ENSP00000262419   ENSP00000459359  
     ENSP00000459330   ENSP00000459627   ENSP00000387393   ENSP00000377117  
    Reactome Protein details: Q7Z3B3

    KANSL1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026180 NSL1

    Graphical View of Domain Structure for InterPro Entry Q7Z3B3

    ProtoNet protein and cluster: Q7Z3B3


    KANSL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KANL1_HUMAN, Q7Z3B3
    Function: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine
    residues and therefore may be involved in the regulation of transcription

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0043995contributes to histone acetyltransferase activity (H4-K5 specific) IDA--
    GO:0043996contributes to histone acetyltransferase activity (H4-K8 specific) IDA--
    GO:0046972contributes to histone acetyltransferase activity (H4-K16 specific) IDA--
         
    KANSL1 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for KANSL1:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Kansl1):
     behavior/neurological  nervous system  other 

    KANSL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KANSL1
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    hsa-mir-17-5p (MIRT050951), hsa-mir-130b-3p (MIRT020287), hsa-mir-149-5p (MIRT045617), hsa-mir-148a-3p (MIRT025982), hsa-mir-23b-3p (MIRT046344), hsa-mir-106b-5p (MIRT044368)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KANL1_HUMAN, Q7Z3B3: Nucleus

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0071339MLL1 complex IDA15960975

    KANSL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for KANSL1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for KANSL1
        HATs acetylate histones



    KANSL1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KANSL1
    Interactions:

        Search GeneGlobe Interaction Network for KANSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KANSL1 (Q7Z3B31, 2, 3 ENSP000002624194) via UniProtKB, MINT, STRING, and/or I2D (see all 601)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP70Q8NHQ12, 3, ENSP000002649824MINT-67988 I2D: score=4 STRING: ENSP00000264982
    KRT15P190122, 3, ENSP000002540434MINT-66716 I2D: score=4 STRING: ENSP00000254043
    SMAD3P840222, 3MINT-61723 I2D: score=2 
    TLN1Q9Y4902, 3MINT-7947479 I2D: score=1 
    CCDC85BQ158341, 2, 3, ENSP000003116954EBI-740244,EBI-739674 MINT-66064 I2D: score=4 STRING: ENSP00000311695
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0043981histone H4-K5 acetylation IDA--
    GO:0043982histone H4-K8 acetylation IDA--
    GO:0043984histone H4-K16 acetylation IDA--

    KANSL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KANSL1 (KANL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KANSL1 gene (3 alternative transcripts): 
    NM_001193465.1  NM_001193466.1  NM_015443.3  

    Unigene Cluster for KANSL1:

    KAT8 regulatory NSL complex subunit 1
    Hs.648744  [show with all ESTs]
    Unigene Representative Sequence: NM_001193466
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572218(uc010wkb.2 uc010wkc.2) ENST00000574590(uc010dav.3)
    ENST00000576870 ENST00000575318 ENST00000572904(uc002ikd.3) ENST00000262419(uc002ikc.3)
    ENST00000574963 ENST00000573682 ENST00000576137 ENST00000573286 ENST00000572679
    ENST00000577114 ENST00000576248 ENST00000574655 ENST00000571698 ENST00000576739
    ENST00000432791 ENST00000393476

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      QuantiTect SYBR Green Assays in human, mouse, rat KANSL1
      QuantiFast Probe-based Assays in human, mouse, rat KANSL1

    Additional mRNA sequence: 

    AB033093.1 AK291259.1 AK310569.1 AL117476.1 AL137317.1 BC035892.1 BC098376.1 BX538006.1 
    XR_159183.1 XR_159184.1 

    17 DOTS entries:

    DT.311087  DT.101975466  DT.100025111  DT.120895352  DT.120895591  DT.95272699  DT.40282897  DT.100742719 
    DT.92064598  DT.101955640  DT.100742722  DT.91904158  DT.95133422  DT.99958218  DT.100876496  DT.95272698 
    DT.97769370 

    Selected AceView cDNA sequences (see all 196):

    BU187705 BM545743 F11156 BU542893 BQ053430 AI253068 AI140989 F05157 
    AA363847 BQ651450 BM915920 AA630638 Z36863 AW005191 BC035892 H88242 
    F03848 BQ373090 AW962129 BQ897985 F01404 AL118845 CK822170 BE772350 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KANSL1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:        -                                                     -     -     -           -                       -                                 
    SP2:                                                              -     -     -           -                       -                                 
    SP3:                                                                                      -     -     -           -                                 
    SP4:                                                                                                                                                
    SP5:                                                              -     -     -           -                       -                                 


    ECgene alternative splicing isoforms for KANSL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KANSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCTGTCTT
    KANSL1 Expression
    About this image

    KANSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KANSL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.648744

    UniProtKB/Swiss-Prot: KANL1_HUMAN, Q7Z3B3
    Tissue specificity: Expressed in the brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KANSL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kansl11 , 5 RIKEN cDNA 1700081L11 gene5
    KAT8 regulatory NSL complex subunit 11
    90.52(n)1
    92.03(a)1
      11 (67.79 cM)5
    767191  NM_001081045.11  NP_001074514.11 
     1043335015 
    chicken
    (Gallus gallus)
    Aves KANSL11 KAT8 regulatory NSL complex subunit 1 74.38(n)
    76.76(a)
      419961  XM_003642786.2  XP_003642834.2 
    lizard
    (Anolis carolinensis)
    Reptilia KANSL16
    KAT8 regulatory NSL complex subunit 1
    71(a)
    1 ↔ 1
    6(67045952-67181879)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.28482 Xenopus laevis transcribed sequence with weak similarity to protein pirT46385 (H.sapiens) T46385 hypothetical protein DKFZp434K031.1 - human (fragment) less 72.34(n)    BU908160.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5678841 KAT8 regulatory NSL complex subunit 1-like 55.48(n)
    50.35(a)
      567884  XM_691191.5  XP_696283.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta wah6
    waharan
    14(a)
    1 → many
    3R(11619498-11627647)


    ENSEMBL Gene Tree for KANSL1 (if available)
    TreeFam Gene Tree for KANSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KANSL1 gene
    KANSL1L2  
    2 SIMAP similar genes for KANSL1 using alignment to 4 protein entries:     KANL1_HUMAN (see all proteins):
    KIAA1267    KANSL1L

    KANSL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KANSL1
    PGOHUM00000237097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KANSL1 (see all 3960)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs25322341,2
    C,F,O,A,H--39934469(-) GGAAAT/CTCGCA 1 -- us2k1 tfbs318Minor allele frequency- C:0.12NA NS EA CSA 1892
    rs1899224341,2
    C--44106951(+) GAGCAA/GCTTAG 3 -- int10--------
    rs1862160181,2
    C--44109087(+) AAGTTC/GCTCTT 3 -- int10--------
    rs1458631941,2
    C,F--44109450(+) AACGGG/ATATCC 6 /T /I mis11Minor allele frequency- A:0.00NA 4552
    rs1468481671,2
    C,F--44109554(+) TGGGAG/ATATTC 6 /Y syn11Minor allele frequency- A:0.00NA 4382
    rs1901428671,2
    C--44109674(+) CACACA/CAAGGA 3 -- int10--------
    rs1175901471,2
    C--44109932(+) AGATTC/TGTGTA 3 -- int11Minor allele frequency- T:0.01EA 120
    rs1868189851,2
    C--44110565(+) TGCAAC/TAGAGC 3 -- int10--------
    rs1396153501,2
    C,F--44110775(+) TCTTCA/CTTCTC 6 K N mis11Minor allele frequency- C:0.00NA 4550
    rs1389191781,2
    C--44111498(+) ATGGGG/TAGAGG 3 -- int10--------

    HapMap Linkage Disequilibrium report for KANSL1 (44107282 - 44302740 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for KANSL1: --
    Human Gene Mutation Database (HGMD): KANSL1
    Locus Specific Mutation Databases (LSDB): KANSL1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KANSL1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612452   
    OMIM disorders: 610443  
    10 diseases for KANSL1:    
    About MalaCards
    koolen-de vries syndrome    kansl1-related intellectual disability syndrome    17q21.31 microdeletion syndrome    koolen-de vries syndrome due to a point mutation
    intellectual disability    parkinson's disease    schizophrenia    thyroiditis
    cerebritis    prostatitis


    KANSL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for KANSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KANSL1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with KANSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. (PubMed id 21217699)1, 2 Kadlec J....Akhtar A. (amp 2011)
    3. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PubMed id 20018852)1, 2 Cai Y.... Conaway R.C. (J. Biol. Chem. 2010)
    4. Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. (PubMed id 16543150)1, 2 Mendjan S.... Akhtar A. (Mol. Cell 2006)
    5. A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. (PubMed id 16227571)1, 2 Smith E.R.... Lucchesi J.C. (Mol. Cell. Biol. 2005)
    6. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A genomic sequence analysis of the mouse and human microtubule- associated protein tau. (PubMed id 11641718)1, 2 Poorkaj P.... Schellenberg G.D. (Mamm. Genome 2001)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284058 HGNC: 24565 AceView: LOC284058 Ensembl:ENSG00000120071 euGenes: HUgn284058
    ECgene: KANSL1 H-InvDB: KANSL1

    (According to HUGE)
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    HUGE: KIAA1267

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KANSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KANSL1 gene:
    Search GeneIP for patents involving KANSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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