V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

KANK4 Gene

protein-coding GIFtS: 40

GC01M062474

KN motif and ankyrin repeat domains 4
(Previous name: ankyrin repeat domain 38 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ANKRD38)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ANKRD38 ^², ³
FLJ10884 ^²
KIAA0172 ^¹, ²
OTTHUMP00000010526 ^²
RP5-1155K23.5 ^²
dJ1078M7.1 ^²

Descriptions
Ankyrin repeat domain-containing protein 38 ^³
KN motif and ankyrin repeat domains 4 ^²
ankyrin repeat domain 38 ^¹, ²
kidney ankyrin repeat-containing protein 4 ^²

External Ids
HGNC: 27263¹
Entrez Gene: 163782²
UniProtKB: Q5T7N3³
Ensembl: ENSG00000132854⁷

Search outside databases for aliases for KANK4 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.3

KANK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M062474: (about GC identifiers)

Start:	62,474,425 bp from pter
End:	62,557,671 bp from pter
Size:	83,247 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3 (See protein sequence)

Recommended Name: KN motif and ankyrin repeat domain-containing protein 4

Size: 995 amino acids; 107342 Da

Secondary accessions: Q6P9A0 Q86T71 Q86VE6 Q8NAX3

Alternative splicing: 2 isoforms: Q5T7N3-1 Q5T7N3-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_859063.3

ENSEMBL proteins:

ENSP00000378871 ENSP00000346352 ENSP00000321161 ENSP00000360192 ENSP00000360195

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (ANKRD38)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for KANK4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KANK4
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for KANK4

Assays for KANK4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5T7N3

ProtoNet protein and cluster: Q5T7N3

UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3

Similarity: Contains 5 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KANK4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181712

Applied Biosystems Silencer® siRNAs for KANK4

Sigma-Aldrich siRNA for KANK4

Sigma-Aldrich shRNA for KANK4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KANK4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_181712
Myc/DDK tagged cDNA clone in CMV expression vector: NM_181712
untagged cDNA clone in CMV expression vector: NM_181712

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181712

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KANK4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KANK4)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181712

Sigma-Aldrich siRNA for KANK4

Sigma-Aldrich shRNA for KANK4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_181712

REFSEQ mRNAs for KANK4 gene:

NM_181712.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_181712

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181712
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181712
                                 untagged cDNA clone in CMV expression vector: NM_181712

Additional cDNA sequence:

AB284127.1 AK091941.1 AK096259.1 AK127461.1 AL832644.2 BC033147.1 BC041418.1 BC060866.1

8 DOTS entries:

DT.40116586 DT.101978803 DT.100751376 DT.86836122 DT.101956906 DT.121413164 DT.121413175 DT.412298

24/74 AceView cDNA sequences (see all 74 ):

BE300482 BQ025863 BU738703 BM701638 BQ879119 BQ022752 AI468658 NM_181712

CF541108 CB960938 AK091941 BC060866 BI494633 BM698610 H50735 BC033147

AA479171 AL832644 AI970049 CB960708 BC041418 AI741903 AW955294 AI333316

Unigene Cluster for KANK4:

KN motif and ankyrin repeat domains 4

Hs.283398 [show with all ESTs]

Unigene Representative Sequence: NM_181712

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KANK4 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11a	·	11b	·	11c
SP1:							-		-		-								-		-
SP2:											-								-		-
SP3:																			-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KANK4

5 Ensembl transcripts including schematic representations:

ENST00000395493 ENST00000354381 ENST00000317477 ENST00000371150 ENST00000371153

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KANK4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KANK4

¹ / ²

5 probe-sets matching KANK4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57312_s_at²	U95-C	1	1.00	1.00	0.85	1.08	--	--	--	--	--
50204_at²	U95-C	1	1.00	1.00	0.86	0.70	--	--	--	--	--
67080_at²	U95-E	1	0.44	1.00	0.90	1.25	--	--	--	--	--
229125_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
229125_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KANK4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.283398

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KANK4 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	KANK4¹	--	KN motif and ankyrin repeat domains 4	84.29(n) 81.37(a)	519027 XM_597235.3 XP_597235.2
rat (Rattus norvegicus)	Kank4¹	--	KN motif and ankyrin repeat domains 4	78.94(n) 74.75(a)	313385 XM_233215.4 XP_233215.4
mouse (Mus musculus)	Kank4^{1, 5}	4⁵	KN motif and ankyrin repeat domains 4^{1, 5}	79(n)¹ 75.13(a)¹	242553¹ NM_172872.2¹ NP_766460.2¹ AK081525⁵ AL670941⁵ (see all 10)
chicken (Gallus gallus)	ANKRD38¹	--	ankyrin repeat domain 38	58.19(n) 50.85(a)	424684 XM_422516.2 XP_422516.2

About this table Species with no ortholog for KANK4

ENSEMBL Gene Tree for KANK4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KANK4 gene

KANK2² KANK1² KANK3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/687 NCBI SNPs in KANK4 are shown (see all 687 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 262)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2258470^1,2	A,C,F,H,O	62501426(-)	`CGATCG/ACAACG`	1	R/H	mis¹		17		EA EU WA NA	2902
	rs2666472^1,2	A,C,F,H,O	62501372(-)	`CATCGC/TGAAGC`	1	V/A	mis¹		12		EU EA WA NA	1054
	rs6688986^1,2	A,C,F,H	62475308(+)	`GCATCT/CGAGCC`	1	--	ut3¹		12		EU EA WA	1256
	rs11207949^1,2	A,C,F,H	62505009(+)	`TGTGGT/CGGTCC`	1	A/T	mis¹ ese³		13		EA NA EU WA	1128
	rs17123306^1,2	C,F,H	62506677(+)	`TGGGCC/TGTCAC`	1	G/S	mis¹ ese³		11		NA EU EA WA	956
	rs2481688^1,2	C,F,H	62475225(-)	`AAATTA/GTCATA`	1	--	ut3¹		4		EU EA WA	400
	rs2941679^1,2	C,F,H	62485812(+)	`GGCCAG/CCATGA`	1	L/V	mis¹		9		EU EA WA NA	912
	rs12144282^1,2	C,F,H	62474329(+)	`CCCATA/CCTGCT`	1	--	ng5¹		12		EU EA WA NA	1050
	rs1050334^1,2	C,F	62475824(-)	`TATTAT/GCTAGT`	1	--	ut3¹		5		EA MN NA	1782
--	rs7531442^1,2	A,C	62558441(+)	`CGCCCA/GCCTCG`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KANK4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

7 PubMed articles for KANK4 gene:

Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)^{2, 3} Zhu Y....Kiyama R. (2008)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 163782	HGNC: 27263	AceView: LOC163782	Ensembl:ENSG00000132854	euGenes: HUgn163782
ECgene: KANK4	H-InvDB: KANK4

(According to HUGE)
About This Section

HUGE: KIAA0172

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KANK4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KANK4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KANK4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KANK4		Antibodies for KANK4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KANK4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ANKRD38)
	Search for Antibodies
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Search for Recombinant Proteins
	Search for Antibodies

Search OriGene for KANK4

Search Tocris compounds for KANK4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KANK4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KANK4 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

KANK4 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for KANK4

Summaries
for KANK4

Genomic Location
for KANK4

Proteins
for KANK4

Protein Domains/
Families
for KANK4

Gene Function
for KANK4

Pathways & Interactions
for KANK4

Drugs & Compounds
for KANK4

Transcripts
for KANK4

Expression
for KANK4

Orthologs
for KANK4

Paralogs
for KANK4

SNPs/Variants
for KANK4

Disorders & Mutations
for KANK4

Medical News
for KANK4

Publications
for KANK4

Search for KANK4

Genome Databases showing KANK4

Other Databases showing KANK4

Specialized Databases showing KANK4

Licensable Technologies
for KANK4

Services
for KANK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KANK4 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor KANK4

Summariesfor KANK4

Genomic Locationfor KANK4

Proteinsfor KANK4

Protein Domains/Familiesfor KANK4

Gene Functionfor KANK4

Pathways & Interactionsfor KANK4

Drugs & Compoundsfor KANK4

Transcriptsfor KANK4

Expression for KANK4

Orthologsfor KANK4

Paralogsfor KANK4

SNPs/Variantsfor KANK4

Disorders & Mutationsfor KANK4

Medical Newsfor KANK4

Publicationsfor KANK4

Search for KANK4

Genome Databases showing KANK4

Other Databases showing KANK4

Specialized Databases showing KANK4

Licensable Technologiesfor KANK4

Servicesfor KANK4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KANK4

Summaries
for KANK4

Genomic Location
for KANK4

Proteins
for KANK4

Protein Domains/
Families
for KANK4

Gene Function
for KANK4

Pathways & Interactions
for KANK4

Drugs & Compounds
for KANK4

Transcripts
for KANK4

Expression
for KANK4

Orthologs
for KANK4

Paralogs
for KANK4

SNPs/Variants
for KANK4

Disorders & Mutations
for KANK4

Medical News
for KANK4

Publications
for KANK4

Licensable Technologies
for KANK4

Services
for KANK4