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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KANK4 Gene

protein-coding   GIFtS: 46
GCID: GC01M062701

KN Motif And Ankyrin Repeat Domains 4

(Previous name: ankyrin repeat domain 38)
(Previous symbol: ANKRD38)
  Search for KANK4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
KN Motif And Ankyrin Repeat Domains 41 2     RP5-1155K23.52
ANKRD381 2 3     dJ1078M7.12
Ankyrin Repeat Domain 381 2     Kidney Ankyrin Repeat-Containing Protein 42
Ankyrin Repeat Domain-Containing Protein 382 3     KN Motif And Ankyrin Repeat Domain-Containing Protein 42

External Ids:    HGNC: 272631   Entrez Gene: 1637822   Ensembl: ENSG000001328547   OMIM: 6146125   UniProtKB: Q5T7N33   

Export aliases for KANK4 gene to outside databases

Previous GC identifers: GC01M062474 GC01M060814


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KANK4 Gene: 
KANK4 (KN motif and ankyrin repeat domains 4) is a protein-coding gene. An important paralog of this gene is KANK2.

UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3
Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KANK4 gene promoter:
         c-Fos   TBP   AP-1   Pax-5   RORalpha2   E47   C/EBPalpha   HEN1   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKANK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for KANK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KANK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.3

KANK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KANK4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M062701:  view genomic region     (about GC identifiers)

Start:
62,701,837 bp from pter      End:
62,785,085 bp from pter
Size:
83,249 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3 (See protein sequence)
Recommended Name: KN motif and ankyrin repeat domain-containing protein 4  
Size: 995 amino acids; 107342 Da
Subcellular location: Cytoplasm
Secondary accessions: B1ALP7 Q6P9A0 Q86T71 Q86VE6 Q8NAX3
Alternative splicing: 2 isoforms:  Q5T7N3-1   Q5T7N3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KANK4: NX_Q5T7N3

Explore proteomics data for KANK4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T7N3

  • KANK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KANK4 Protein Expression
    REFSEQ proteins: NP_859063.3  
    ENSEMBL proteins: 
     ENSP00000321161   ENSP00000360195   ENSP00000360192   ENSP00000346352  

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    Novus Biologicals KANK4 Protein
    Novus Biologicals KANK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for KANK4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    KANK4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing
    KANK: KN motif and ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR021939 KN_motif
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q5T7N3

    ProtoNet protein and cluster: Q5T7N3

    UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3
    Similarity: Contains 5 ANK repeats


    KANK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KANK4_HUMAN, Q5T7N3
    Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    KANK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KANK4:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KANK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KANK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KANK4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KANK4 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKANK4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KANK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/6 Interacting proteins for KANK4 (ENSP000003601954) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204364ENSP000003646604STRING: ENSP00000364660
    ENSG00000224472ENSP000004149804STRING: ENSP00000414980
    ENSG00000225691ENSP000004074314STRING: ENSP00000407431
    ENSG00000235068ENSP000004050414STRING: ENSP00000405041
    POLR3CENSP000003345644STRING: ENSP00000334564
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KANK4

    Search CenterWatch for drugs/clinical trials and news about KANK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KANK4 gene: 
    NM_181712.4  

    Unigene Cluster for KANK4:

    KN motif and ankyrin repeat domains 4
    Hs.283398  [show with all ESTs]
    Unigene Representative Sequence: NM_181712
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317477(uc001daf.4) ENST00000371153(uc001dah.4 uc001dai.4)
    ENST00000371150(uc001dag.4) ENST00000354381
    miRNA
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    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate KANK4 (see all 32):
    hsa-miR-605 hsa-miR-765 hsa-miR-548l hsa-miR-124 hsa-miR-489 hsa-miR-506 hsa-miR-548am hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidKANK4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KANK4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KANK4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KANK4

    Additional mRNA sequence: 

    AB284127.1 AK091941.1 AK096259.1 AK127461.1 AL832644.2 BC033147.1 BC041418.1 BC060866.1 

    8 DOTS entries:

    DT.40116586  DT.101978803  DT.100751376  DT.86836122  DT.101956906  DT.121413164  DT.121413175  DT.412298 

    24/74 AceView cDNA sequences (see all 74):

    BQ022752 AI468658 BQ879119 BQ025863 BE300482 BU738703 BM701638 AI381634 
    AI333316 AK127461 BC041418 NM_181712 BM698610 CF541108 CB960938 BC033147 
    AI970049 BG825977 BI090563 AA479171 BI494632 AI420038 BC060866 BU736248 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for KANK4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                    -     -     -                       -     -                                       
    SP2:                                -                       -     -                                       
    SP3:                                                        -     -                                       
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for KANK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KANK4 expression in normal human tissues (normalized intensities)      KANK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KANK4 Expression
    About this image


    KANK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             N2/LSB induced-cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 9 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Endothelial Cells Blood Brain Barrier
             Endothelial progenitor cells ( Derivation and purification of endothelial precursor...
             Human Villous Capillary Endothelial Cells (HVCEC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 3 entries
             PureStem Progenitor EN7

    See KANK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KANK4

    SOURCE GeneReport for Unigene cluster: Hs.283398

    UniProtKB/Swiss-Prot: KANK4_HUMAN, Q5T7N3
    Tissue specificity: Strongly expressed in colon, liver, lung, skeletal muscle and kidney

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KANK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KANK4 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kank41 , 5 KN motif and ankyrin repeat domains 41, 5 79(n)1
    75.13(a)1
      4 (45.60 cM)5
    2425531  NM_172872.31  NP_766460.21 
     987548985 
    chicken
    (Gallus gallus)
    Aves KANK41 KN motif and ankyrin repeat domains 4 58.35(n)
    50.74(a)
      424684  XM_422516.3  XP_422516.3 
    lizard
    (Anolis carolinensis)
    Reptilia KANK46
    Uncharacterized protein
    49(a)
    1 ↔ 1
    4(100053937-100081139)
    zebrafish
    (Danio rerio)
    Actinopterygii CU570976.16
    Uncharacterized protein
    24(a)
    1 ↔ 1
    6(32173529-32198604)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102496
    --
    16(a)
    1 ↔ 1
    2R(10788980-10815930)


    ENSEMBL Gene Tree for KANK4 (if available)
    TreeFam Gene Tree for KANK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KANK4 gene
    KANK22  KANK12  KANK32  
    13 SIMAP similar genes for KANK4 using alignment to 3 protein entries:     KANK4_HUMAN (see all proteins):
    Kank4    KANK2    KANK1    Kank3    DKFZp666N084    ANK3
    KANK3    ANKRD50    ANK2    ANKDD1B    ANKRD62    TNKS
    ANKRD29

    KANK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2019 SNPs in KANK4 are shown (see all 2019)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399683421,2
    Cuntested162728928(+) TAGACA/GACTTC 2 S L mis10--------
    rs1878677641,2
    --62701596(+) TCAAGC/TTCTAG 1 -- ds50010--------
    rs1920878661,2
    --62701652(+) ATTTCA/GTTTTT 1 -- ds50010--------
    rs1131858231,2
    C--62701671(+) ACCCAG/ATGAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1157160661,2
    C,F--62701685(+) GCCACC/GTAATA 1 -- ds50011Minor allele frequency- G:0.04NA 120
    rs121442821,2
    C,F,H--62701741(+) CCCATA/CCTGCT 1 -- ds500128Minor allele frequency- N:0.00NS EA NA CSA 2865
    rs1505432891,2
    C--62701801(+) CCAAGA/GGCAAA 1 -- ds50010--------
    rs1384791821,2
    --62701877(+) ATAGGC/TCAGAG 1 -- ut310--------
    rs1893797361,2
    --62702053(+) ATTAAC/TGTAGG 1 -- ut310--------
    rs1149150591,2
    C,F--62702100(+) ACTCAT/CTTAAA 1 -- ut311Minor allele frequency- C:0.04NA 120

    HapMap Linkage Disequilibrium report for KANK4 (62701837 - 62785085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KANK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660405CNV Deletion23128226
    esv2457868CNV Deletion19546169
    nsv525191CNV Loss19592680
    nsv520333CNV Loss19592680
    nsv871250CNV Gain21882294
    nsv871893CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing KANK4
    DNA2.0 Custom Variant and Variant Library Synthesis for KANK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    KANK4 for disorders           About MalaCards
    OMIM gene information: 614612    OMIM disorders: --


    KANK4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KANK4

    Export disorders for KANK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KANK4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KANK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)1, 2, 3 Zhu Y.... Kiyama R. (2008)
    2. Kank proteins: structure, functions and diseases. (PubMed id 19554261)1, 3 Kakinuma N....Kiyama R. (2009)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 163782 HGNC: 27263 AceView: LOC163782 Ensembl:ENSG00000132854 euGenes: HUgn163782
    ECgene: KANK4 H-InvDB: KANK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KANK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KANK4 gene:
    Search GeneIP for patents involving KANK4

    GeneCards and IP:
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