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Aliases for KANK4 Gene

Aliases for KANK4 Gene

  • KN Motif And Ankyrin Repeat Domains 4 2 3
  • Ankyrin Repeat Domain-Containing Protein 38 3 4
  • Ankyrin Repeat Domain 38 2 3
  • ANKRD38 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 4 3
  • Kidney Ankyrin Repeat-Containing Protein 4 3
  • DJ1078M7.1 3

External Ids for KANK4 Gene

Previous HGNC Symbols for KANK4 Gene

  • ANKRD38

Previous GeneCards Identifiers for KANK4 Gene

  • GC01M062474
  • GC01M062701
  • GC01M060814

Summaries for KANK4 Gene

GeneCards Summary for KANK4 Gene

KANK4 (KN Motif And Ankyrin Repeat Domains 4) is a Protein Coding gene. An important paralog of this gene is KANK3.

UniProtKB/Swiss-Prot for KANK4 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK4 Gene

Genomics for KANK4 Gene

Regulatory Elements for KANK4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KANK4 Gene

Start:
62,236,165 bp from pter
End:
62,319,414 bp from pter
Size:
83,250 bases
Orientation:
Minus strand

Genomic View for KANK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KANK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK4 Gene

Proteins for KANK4 Gene

  • Protein details for KANK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7N3-KANK4_HUMAN
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 4
    Protein Accession:
    Q5T7N3
    Secondary Accessions:
    • B1ALP7
    • Q6P9A0
    • Q86T71
    • Q86VE6
    • Q8NAX3

    Protein attributes for KANK4 Gene

    Size:
    995 amino acids
    Molecular mass:
    107342 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANK4 Gene

Proteomics data for KANK4 Gene at MOPED

Post-translational modifications for KANK4 Gene

  • Ubiquitination at Lys642
  • Modification sites at PhosphoSitePlus

Other Protein References for KANK4 Gene

No data available for DME Specific Peptides for KANK4 Gene

Domains for KANK4 Gene

Gene Families for KANK4 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • KANK :KN motif and ankyrin repeat domain containing

Protein Domains for KANK4 Gene

Suggested Antigen Peptide Sequences for KANK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7N3

UniProtKB/Swiss-Prot:

KANK4_HUMAN :
  • Q5T7N3
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with KANK4: view

Function for KANK4 Gene

Molecular function for KANK4 Gene

UniProtKB/Swiss-Prot Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization

Gene Ontology (GO) - Molecular Function for KANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KANK4: view

Phenotypes for KANK4 Gene

GenomeRNAi human phenotypes for KANK4:
genes like me logo Genes that share phenotypes with KANK4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KANK4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KANK4 Gene

Localization for KANK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANK4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANK4 Gene COMPARTMENTS Subcellular localization image for KANK4 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for KANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KANK4: view

Pathways for KANK4 Gene

SuperPathways for KANK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK4 Gene

None

No data available for Pathways by source for KANK4 Gene

Transcripts for KANK4 Gene

Unigene Clusters for KANK4 Gene

KN motif and ankyrin repeat domains 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KANK4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KANK4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANK4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: - -

Relevant External Links for KANK4 Gene

GeneLoc Exon Structure for
KANK4
ECgene alternative splicing isoforms for
KANK4

Expression for KANK4 Gene

mRNA expression in normal human tissues for KANK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KANK4 Gene

This gene is overexpressed in Nerve - Tibial (14.5), Pancreas (7.5), Brain - Spinal cord (cervical c-1) (6.3), and Brain - Substantia nigra (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KANK4 Gene

SOURCE GeneReport for Unigene cluster for KANK4 Gene Hs.283398

mRNA Expression by UniProt/SwissProt for KANK4 Gene

Q5T7N3-KANK4_HUMAN
Tissue specificity: Strongly expressed in colon, liver, lung, skeletal muscle and kidney.
genes like me logo Genes that share expressions with KANK4: view

In Situ Assay Products

Orthologs for KANK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANK4 35
  • 98.36 (n)
  • 97.59 (a)
KANK4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KANK4 35
  • 83.22 (n)
  • 79.86 (a)
KANK4 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANK4 35
  • 85.58 (n)
  • 82.49 (a)
KANK4 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kank4 35
  • 78.63 (n)
  • 74.52 (a)
Kank4 16
Kank4 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANK4 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANK4 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kank4 35
  • 78.82 (n)
  • 74.55 (a)
chicken
(Gallus gallus)
Aves KANK4 35
  • 59.04 (n)
  • 51.49 (a)
KANK4 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KANK4 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kank4 35
  • 60.07 (n)
  • 57 (a)
zebrafish
(Danio rerio)
Actinopterygii kank4 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10249 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-19 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
ManyToMany
CSA.3164 36
  • 25 (a)
ManyToMany
Species with no ortholog for KANK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KANK4 Gene

ENSEMBL:
Gene Tree for KANK4 (if available)
TreeFam:
Gene Tree for KANK4 (if available)

Paralogs for KANK4 Gene

Paralogs for KANK4 Gene

Selected SIMAP similar genes for KANK4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KANK4: view

Variants for KANK4 Gene

Sequence variations from dbSNP and Humsavar for KANK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs765691 -- 62,294,176(-) TAGTA(A/T)CAAAG intron-variant
rs765692 -- 62,294,057(-) AGAAG(C/T)AGTTT intron-variant
rs881548 -- 62,307,111(+) ACTTC(C/G)TCCAG intron-variant
rs882334 -- 62,308,032(-) AGGGT(A/G)GATAC intron-variant
rs912894 -- 62,302,783(-) ACGGG(G/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KANK4 Gene

Variant ID Type Subtype PubMed ID
esv2457868 CNV Deletion 19546169
esv2660405 CNV Deletion 23128226
nsv520333 CNV Loss 19592680
nsv871893 CNV Gain 21882294
nsv871250 CNV Gain 21882294
nsv525191 CNV Loss 19592680

Relevant External Links for KANK4 Gene

HapMap Linkage Disequilibrium report
KANK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK4 Gene

Disorders for KANK4 Gene

Relevant External Links for KANK4

Genetic Association Database (GAD)
KANK4
genes like me logo Genes that share disorders with KANK4: view

No data available for UniProtKB/Swiss-Prot for KANK4 Gene

Publications for KANK4 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y. … Kiyama R. (Biochim. Biophys. Acta 2008) 2 3 4
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N. … Kiyama R. (Cell. Mol. Life Sci. 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for KANK4 Gene

Sources for KANK4 Gene

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