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Aliases for KANK4 Gene

Aliases for KANK4 Gene

  • KN Motif And Ankyrin Repeat Domains 4 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 38 3 4
  • Ankyrin Repeat Domain 38 2 3
  • ANKRD38 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 4 3
  • Kidney Ankyrin Repeat-Containing Protein 4 3
  • DJ1078M7.1 3

External Ids for KANK4 Gene

Previous HGNC Symbols for KANK4 Gene

  • ANKRD38

Previous GeneCards Identifiers for KANK4 Gene

  • GC01M062474
  • GC01M062701
  • GC01M060814

Summaries for KANK4 Gene

GeneCards Summary for KANK4 Gene

KANK4 (KN Motif And Ankyrin Repeat Domains 4) is a Protein Coding gene. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot for KANK4 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK4 Gene

Genomics for KANK4 Gene

Regulatory Elements for KANK4 Gene

Enhancers for KANK4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KANK4 on UCSC Golden Path with GeneCards custom track

Promoters for KANK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for KANK4 Gene

62,236,165 bp from pter
62,319,414 bp from pter
83,250 bases
Minus strand

Genomic View for KANK4 Gene

Genes around KANK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK4 Gene

Proteins for KANK4 Gene

  • Protein details for KANK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • B1ALP7
    • Q6P9A0
    • Q86T71
    • Q86VE6
    • Q8NAX3

    Protein attributes for KANK4 Gene

    995 amino acids
    Molecular mass:
    107342 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK4 Gene


neXtProt entry for KANK4 Gene

Post-translational modifications for KANK4 Gene

  • Ubiquitination at Lys 642
  • Modification sites at PhosphoSitePlus

Other Protein References for KANK4 Gene

No data available for DME Specific Peptides for KANK4 Gene

Domains & Families for KANK4 Gene

Protein Domains for KANK4 Gene

Suggested Antigen Peptide Sequences for KANK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 ANK repeats.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with KANK4: view

Function for KANK4 Gene

Molecular function for KANK4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
genes like me logo Genes that share phenotypes with KANK4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KANK4 Gene

Localization for KANK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANK4 Gene


Subcellular locations from

Jensen Localization Image for KANK4 Gene COMPARTMENTS Subcellular localization image for KANK4 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for KANK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with KANK4: view

Pathways & Interactions for KANK4 Gene

SuperPathways for KANK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK4 Gene


No data available for Pathways by source and SIGNOR curated interactions for KANK4 Gene

Drugs & Compounds for KANK4 Gene

No Compound Related Data Available

Transcripts for KANK4 Gene

Unigene Clusters for KANK4 Gene

KN motif and ankyrin repeat domains 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANK4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - -
SP3: - -
SP6: - -

Relevant External Links for KANK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KANK4 Gene

mRNA expression in normal human tissues for KANK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KANK4 Gene

This gene is overexpressed in Nerve - Tibial (x14.5), Pancreas (x7.5), Brain - Spinal cord (cervical c-1) (x6.3), and Brain - Substantia nigra (x5.1).

Protein differential expression in normal tissues from HIPED for KANK4 Gene

This gene is overexpressed in Pancreas (27.7), Adrenal (13.7), Fetal ovary (9.0), and Salivary gland (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KANK4 Gene

Protein tissue co-expression partners for KANK4 Gene

NURSA nuclear receptor signaling pathways regulating expression of KANK4 Gene:


SOURCE GeneReport for Unigene cluster for KANK4 Gene:


mRNA Expression by UniProt/SwissProt for KANK4 Gene:

Tissue specificity: Strongly expressed in colon, liver, lung, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with KANK4: view

Primer Products

Orthologs for KANK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KANK4 34
  • 83.22 (n)
  • 79.86 (a)
KANK4 35
  • 87 (a)
(Canis familiaris)
Mammalia KANK4 34
  • 85.58 (n)
  • 82.49 (a)
KANK4 35
  • 82 (a)
(Mus musculus)
Mammalia Kank4 34
  • 78.63 (n)
  • 74.52 (a)
Kank4 16
Kank4 35
  • 73 (a)
(Pan troglodytes)
Mammalia KANK4 34
  • 98.36 (n)
  • 97.59 (a)
KANK4 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Kank4 34
  • 78.82 (n)
  • 74.55 (a)
(Monodelphis domestica)
Mammalia KANK4 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia KANK4 35
  • 44 (a)
(Gallus gallus)
Aves KANK4 34
  • 59.04 (n)
  • 51.49 (a)
KANK4 35
  • 47 (a)
(Anolis carolinensis)
Reptilia KANK4 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kank4 34
  • 60.07 (n)
  • 57 (a)
(Danio rerio)
Actinopterygii kank4 35
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10249 35
  • 15 (a)
(Caenorhabditis elegans)
Secernentea vab-19 35
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 10 (a)
CSA.3164 35
  • 25 (a)
Species where no ortholog for KANK4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KANK4 Gene

Gene Tree for KANK4 (if available)
Gene Tree for KANK4 (if available)

Paralogs for KANK4 Gene

Paralogs for KANK4 Gene

(13) SIMAP similar genes for KANK4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KANK4: view

Variants for KANK4 Gene

Sequence variations from dbSNP and Humsavar for KANK4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2258470 - 62,263,166(-) CGATC(A/G/T)CAACG nc-transcript-variant, reference, missense
rs2666472 - 62,263,112(-) CATCG(C/G/T)GAAGC nc-transcript-variant, reference, missense
rs2941679 - 62,247,552(+) GGCCA(C/G)CATGA nc-transcript-variant, reference, missense
rs17123306 - 62,268,417(+) TGGGC(C/T)GTCAC nc-transcript-variant, reference, missense
rs11207949 - 62,266,749(+) TGTGG(C/T)GGTCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KANK4 Gene

Variant ID Type Subtype PubMed ID
esv2457868 CNV deletion 19546169
esv2660405 CNV deletion 23128226
esv3562982 CNV deletion 23714750
esv3562993 CNV deletion 23714750
esv3577900 CNV loss 25503493
esv3586233 CNV loss 21293372
esv3893601 CNV loss 25118596
nsv1122353 CNV deletion 24896259
nsv520333 CNV loss 19592680
nsv525191 CNV loss 19592680

Variation tolerance for KANK4 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.31; 88.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANK4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK4 Gene

Disorders for KANK4 Gene

Relevant External Links for KANK4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KANK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANK4 Gene

Publications for KANK4 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y. … Kiyama R. (Biochim. Biophys. Acta 2008) 2 3 4 65
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N. … Kiyama R. (Cell. Mol. Life Sci. 2009) 2 3 65
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for KANK4 Gene

Sources for KANK4 Gene

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