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Aliases for KANK3 Gene

Aliases for KANK3 Gene

  • KN Motif And Ankyrin Repeat Domains 3 2 3
  • Ankyrin Repeat Domain-Containing Protein 47 3 4
  • Ankyrin Repeat Domain 47 2 3
  • ANKRD47 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 3 3
  • Kidney Ankyrin Repeat-Containing Protein 3 3

External Ids for KANK3 Gene

Previous HGNC Symbols for KANK3 Gene

  • ANKRD47

Previous GeneCards Identifiers for KANK3 Gene

  • GC19M008297
  • GC19M008041
  • GC19M008387

Summaries for KANK3 Gene

GeneCards Summary for KANK3 Gene

KANK3 (KN Motif And Ankyrin Repeat Domains 3) is a Protein Coding gene. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot for KANK3 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK3 Gene

Genomics for KANK3 Gene

Regulatory Elements for KANK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KANK3 Gene

Start:
8,322,584 bp from pter
End:
8,343,262 bp from pter
Size:
20,679 bases
Orientation:
Minus strand

Genomic View for KANK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KANK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK3 Gene

Proteins for KANK3 Gene

  • Protein details for KANK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NY19-KANK3_HUMAN
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 3
    Protein Accession:
    Q6NY19
    Secondary Accessions:
    • Q6NZI1
    • Q6ZQR3
    • Q8IUV2

    Protein attributes for KANK3 Gene

    Size:
    840 amino acids
    Molecular mass:
    88425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANK3 Gene

Proteomics data for KANK3 Gene at MOPED

Post-translational modifications for KANK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KANK3 Gene

Antibody Products

No data available for DME Specific Peptides for KANK3 Gene

Domains for KANK3 Gene

Gene Families for KANK3 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • KANK :KN motif and ankyrin repeat domain containing

Protein Domains for KANK3 Gene

Suggested Antigen Peptide Sequences for KANK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NY19

UniProtKB/Swiss-Prot:

KANK3_HUMAN :
  • Q6NY19
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with KANK3: view

Function for KANK3 Gene

Molecular function for KANK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization

Gene Ontology (GO) - Molecular Function for KANK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KANK3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KANK3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KANK3 Gene

Localization for KANK3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANK3 Gene COMPARTMENTS Subcellular localization image for KANK3 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KANK3 Gene

Pathways for KANK3 Gene

SuperPathways for KANK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK3 Gene

None

No data available for Pathways by source for KANK3 Gene

Transcripts for KANK3 Gene

Unigene Clusters for KANK3 Gene

KN motif and ankyrin repeat domains 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KANK3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANK3 Gene

No ASD Table

Relevant External Links for KANK3 Gene

GeneLoc Exon Structure for
KANK3
ECgene alternative splicing isoforms for
KANK3

Expression for KANK3 Gene

mRNA expression in normal human tissues for KANK3 Gene

mRNA differential expression in normal tissues according to GTEx for KANK3 Gene

This gene is overexpressed in Spleen (4.3).

Protein differential expression in normal tissues for KANK3 Gene

This gene is overexpressed in Lung (15.2), Placenta (8.6), and Esophagus (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KANK3 Gene

SOURCE GeneReport for Unigene cluster for KANK3 Gene Hs.745036

mRNA Expression by UniProt/SwissProt for KANK3 Gene

Q6NY19-KANK3_HUMAN
Tissue specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney.
genes like me logo Genes that share expressions with KANK3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for KANK3 Gene

Orthologs for KANK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KANK3 35
  • 83.5 (n)
  • 80.65 (a)
KANK3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANK3 35
  • 83.81 (n)
  • 80.62 (a)
KANK3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kank3 35
  • 76.5 (n)
  • 76.2 (a)
Kank3 16
Kank3 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KANK3 35
  • 99.07 (n)
  • 98.78 (a)
KANK3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kank3 35
  • 78.24 (n)
  • 78.2 (a)
oppossum
(Monodelphis domestica)
Mammalia KANK3 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANK3 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves KANK3 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii kank3 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10249 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-19 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.3164 36
  • 23 (a)
ManyToMany
Species with no ortholog for KANK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KANK3 Gene

ENSEMBL:
Gene Tree for KANK3 (if available)
TreeFam:
Gene Tree for KANK3 (if available)

Paralogs for KANK3 Gene

Paralogs for KANK3 Gene

Selected SIMAP similar genes for KANK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KANK3: view

Variants for KANK3 Gene

Sequence variations from dbSNP and Humsavar for KANK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs710949 -- 8,334,744(-) GCCAG(C/T)CTGGA synonymous-codon, reference
rs732217 -- 8,324,223(-) CAGCC(A/T)CAAAC intron-variant
rs737228 -- 8,337,758(-) TGTGC(A/G)CATGC intron-variant
rs737229 -- 8,337,719(-) TGGAC(A/G)CAGCC intron-variant
rs890850 - 8,334,965(-) TCCTC(G/T)ACGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KANK3 Gene

Variant ID Type Subtype PubMed ID
dgv3718n71 CNV Loss 21882294
dgv3719n71 CNV Loss 21882294
nsv911001 CNV Loss 21882294
esv2718120 CNV Deletion 23290073
esv2718121 CNV Deletion 23290073
esv2718122 CNV Deletion 23290073

Relevant External Links for KANK3 Gene

HapMap Linkage Disequilibrium report
KANK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK3 Gene

Disorders for KANK3 Gene

No disorders were found for KANK3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KANK3 Gene

Publications for KANK3 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y. … Kiyama R. (Biochim. Biophys. Acta 2008) 2 3 4
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N. … Kiyama R. (Cell. Mol. Life Sci. 2009) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 3

Products for KANK3 Gene

Sources for KANK3 Gene

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