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Aliases for KANK3 Gene

Aliases for KANK3 Gene

  • KN Motif And Ankyrin Repeat Domains 3 2 3 5
  • Ankyrin Repeat Domain-Containing Protein 47 3 4
  • Ankyrin Repeat Domain 47 2 3
  • ANKRD47 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 3 3
  • Kidney Ankyrin Repeat-Containing Protein 3 3

External Ids for KANK3 Gene

Previous HGNC Symbols for KANK3 Gene

  • ANKRD47

Previous GeneCards Identifiers for KANK3 Gene

  • GC19M008297
  • GC19M008041
  • GC19M008387

Summaries for KANK3 Gene

GeneCards Summary for KANK3 Gene

KANK3 (KN Motif And Ankyrin Repeat Domains 3) is a Protein Coding gene. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot for KANK3 Gene

  • May be involved in the control of cytoskeleton formation by regulating actin polymerization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK3 Gene

Genomics for KANK3 Gene

Regulatory Elements for KANK3 Gene

Enhancers for KANK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008340 1.2 Ensembl ENCODE 5.6 +1.1 1144 3.6 ATF1 PKNOX1 ZNF121 GLIS2 ZNF143 FOS CEBPZ SP3 SP5 NFYC RPS28 ELAVL1 HNRNPM ZNF558 ZNF699 CD320 KANK3 PIR52170
GH19F008139 0.6 Ensembl ENCODE 5.6 +203.5 203502 0.8 BCOR SMARCA5 RFX1 NFIA ZNF580 ZMYM3 ZNF384 KDM1A KANK3 GC19M008115 FBN3
GH19F008333 0.5 ENCODE 0.4 +9.4 9437 0.1 ZNF263 ZFHX2 GLIS1 EGR2 EZH2 RPS28 KANK3 PIR52170
GH19F008334 0.5 ENCODE 0.4 +7.9 7886 0.9 CTCF ZNF146 MAX SIN3A UBTF E2F1 ZFHX2 POLR2A ZNF600 E2F6 RPS28 KANK3 PIR52170
GH19F008324 0.5 ENCODE 0.3 +18.4 18351 0.2 PKNOX1 ARNT CREB3L1 ARID4B ZNF2 YY1 ZNF207 ZNF548 PAF1 SP3 ZNF558 ZNF699 ZNF559 ELAVL1 HNRNPM XAB2 RPS28 LINC01862 ENSG00000261866 LYPLA2P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KANK3 on UCSC Golden Path with GeneCards custom track

Promoters for KANK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140354 262 1201 ATF1 PKNOX1 RAD21 GLIS2 ZNF143 FOS CREM SMARCA5 SP3 SP5

Genomic Location for KANK3 Gene

8,322,582 bp from pter
8,343,262 bp from pter
20,681 bases
Minus strand

Genomic View for KANK3 Gene

Genes around KANK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KANK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KANK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK3 Gene

Proteins for KANK3 Gene

  • Protein details for KANK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q6NZI1
    • Q6ZQR3
    • Q8IUV2

    Protein attributes for KANK3 Gene

    840 amino acids
    Molecular mass:
    88425 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KANK3 Gene


neXtProt entry for KANK3 Gene

Post-translational modifications for KANK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KANK3 Gene

No data available for DME Specific Peptides for KANK3 Gene

Domains & Families for KANK3 Gene

Protein Domains for KANK3 Gene

Suggested Antigen Peptide Sequences for KANK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 ANK repeats.
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with KANK3: view

Function for KANK3 Gene

Molecular function for KANK3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
genes like me logo Genes that share phenotypes with KANK3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KANK3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KANK3 Gene

Localization for KANK3 Gene

Subcellular locations from

Jensen Localization Image for KANK3 Gene COMPARTMENTS Subcellular localization image for KANK3 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KANK3 Gene

Pathways & Interactions for KANK3 Gene

SuperPathways for KANK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK3 Gene


No data available for Pathways by source and SIGNOR curated interactions for KANK3 Gene

Transcripts for KANK3 Gene

Unigene Clusters for KANK3 Gene

KN motif and ankyrin repeat domains 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KANK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KANK3 Gene

No ASD Table

Relevant External Links for KANK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KANK3 Gene

mRNA expression in normal human tissues for KANK3 Gene

mRNA differential expression in normal tissues according to GTEx for KANK3 Gene

This gene is overexpressed in Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for KANK3 Gene

This gene is overexpressed in Lung (15.2), Placenta (8.6), and Esophagus (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KANK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KANK3 Gene:


SOURCE GeneReport for Unigene cluster for KANK3 Gene:


mRNA Expression by UniProt/SwissProt for KANK3 Gene:

Tissue specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with KANK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for KANK3 Gene

Orthologs for KANK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KANK3 34 35
  • 99.07 (n)
(Canis familiaris)
Mammalia KANK3 34 35
  • 83.81 (n)
(Bos Taurus)
Mammalia KANK3 34 35
  • 83.5 (n)
(Rattus norvegicus)
Mammalia Kank3 34
  • 78.24 (n)
(Mus musculus)
Mammalia Kank3 34 16 35
  • 76.5 (n)
(Ornithorhynchus anatinus)
Mammalia KANK3 35
  • 56 (a)
(Monodelphis domestica)
Mammalia KANK3 35
  • 55 (a)
(Gallus gallus)
Aves KANK3 35
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
(Danio rerio)
Actinopterygii kank3 35
  • 34 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10249 35
  • 16 (a)
(Caenorhabditis elegans)
Secernentea vab-19 35
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
CSA.3164 35
  • 23 (a)
Species where no ortholog for KANK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KANK3 Gene

Gene Tree for KANK3 (if available)
Gene Tree for KANK3 (if available)

Paralogs for KANK3 Gene

Paralogs for KANK3 Gene

(10) SIMAP similar genes for KANK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KANK3: view

Variants for KANK3 Gene

Sequence variations from dbSNP and Humsavar for KANK3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1019757 -- 8,324,636(-) ATCCT(A/G)GACAA nc-transcript-variant, reference, synonymous-codon
rs10404152 -- 8,327,662(+) GGTGG(G/T)TCATG intron-variant
rs10405061 -- 8,341,496(+) atctc(C/T)gcctc intron-variant
rs10406333 -- 8,336,757(+) aaaaa(A/G)GTTGG intron-variant
rs10409529 -- 8,325,832(+) CAACt(A/G)tttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KANK3 Gene

Variant ID Type Subtype PubMed ID
esv2718120 CNV deletion 23290073
esv2718121 CNV deletion 23290073
esv2718122 CNV deletion 23290073
esv3643614 CNV gain 21293372

Variation tolerance for KANK3 Gene

Gene Damage Index Score: 24.59; 99.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KANK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK3 Gene

Disorders for KANK3 Gene

Relevant External Links for KANK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KANK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KANK3 Gene

Publications for KANK3 Gene

  1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y. … Kiyama R. (Biochim. Biophys. Acta 2008) 2 3 4 64
  2. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N. … Kiyama R. (Cell. Mol. Life Sci. 2009) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for KANK3 Gene

Sources for KANK3 Gene

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