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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KANK3 Gene

protein-coding   GIFtS: 40
GCID: GC19M008387

KN motif and ankyrin repeat domains 3

(Previous name: ankyrin repeat domain 47 )
(Previous symbol: ANKRD47)
 Explore 1 disease affiliated with
KANK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KANK3    

Aliases
for KANK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
KN Motif And Ankyrin Repeat Domains 31 2     FLJ460611
ANKRD471 2 3     Kidney Ankyrin Repeat-Containing Protein 32
Ankyrin Repeat Domain 471 2     KN Motif And Ankyrin Repeat Domain-Containing Protein 32
Ankyrin Repeat Domain-Containing Protein 472 3     

External Ids:    HGNC: 247961   Entrez Gene: 2569492   Ensembl: ENSG000001869947   OMIM: 6146115   UniProtKB: Q6NY193   

Export aliases for KANK3 gene to outside databases

Previous GC identifers: GC19M008297 GC19M008041


Summaries
for KANK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19
Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization




Genomic Views
for KANK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_077812.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KANK3 gene promoter:
         GATA-2   CREB   PPAR-gamma1   CP2   deltaCREB   c-Myb   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KANK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for KANK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KANK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

KANK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KANK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M008387:  view genomic region     (about GC identifiers)

Start:
 8,387,468 bp from pter      End:
 8,408,146 bp from pter
Size:
 20,679 bases      Orientation:
 minus strand

Proteins
for KANK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19 (See protein sequence)
Recommended Name: KN motif and ankyrin repeat domain-containing protein 3  
Size: 840 amino acids; 88425 Da
Secondary accessions: Q6NZI1 Q6ZQR3 Q8IUV2
Alternative splicing: 2 isoforms:  Q6NY19-1   Q6NY19-2   

Explore the universe of human proteins at neXtProt for KANK3: NX_Q6NY19

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NY19

    • KANK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_940873.2  
    ENSEMBL proteins: 
     ENSP00000328923  

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    Protein Domains /
    Families
    for KANK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KANK3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR021939 KN_motif
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q6NY19

    ProtoNet protein and cluster: Q6NY19

    1 Blocks protein family: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19
    Similarity: Contains 5 ANK repeats


    Function
    for KANK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19
    Function: May be involved in the control of cytoskeleton formation by regulating actin polymerization

    miRNA
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    Pathways & Interactions
    for KANK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KANK3

    Drugs & Compounds
    for KANK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KANK3
    Search CenterWatch for drugs/clinical trials and news about KANK3 

    Transcripts
    for KANK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KANK3 gene: 
    NM_198471.2  

    Unigene Cluster for KANK3:

    KN motif and ankyrin repeat domains 3
    Hs.322473  [show with all ESTs]
    Unigene Representative Sequence: NM_198471
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330915(uc010dwa.3 uc002mjp.1)

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AB284126.1 AK097023.1 AK128815.1 BC035849.2 BC066124.1 BC066775.1 

    9 DOTS entries:

    DT.100685164  DT.102838910  DT.86854456  DT.95334037  DT.99930492  DT.100700773  DT.75156693  DT.451349 
    DT.99999059 

    24/537 AceView cDNA sequences (see all 537):

    BU165223 BU181748 BM719394 BP343142 CR624802 BQ012380 CR621881 AJ712866 
    AI675995 AA622394 CF528604 BU194469 AF050637 CA489619 CB141050 BM750449 
    BQ012874 BG164140 AW024981 BE382788 BE313915 CB106682 AF161254 CR603782 

    GeneLoc Exon Structure


    Expression
    for KANK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KANK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCACCTGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    KANK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See KANK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KANK3

    SOURCE GeneReport for Unigene cluster: Hs.322473

    UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19
    Tissue specificity: Strongly expressed in breast, liver, lung, skeletal muscle and kidney

        SABiosciences Custom PCR Arrays for KANK3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KANK3

    Orthologs
    for KANK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KANK3 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves KANK36
    		 Uncharacterized protein
    		 39(a)
    		 1 ↔ 1
    		 28(858924-865719)
    zebrafish
    (Danio rerio)    		 Actinopterygii kank36
    		 KN motif and ankyrin repeat domains 3
    		 33(a)
    		 1 ↔ 1
    		 8(49914159-49982349)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG102496
    		 --
    		 13(a)
    		 1 → many
    		 2R(10788980-10815930)
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-196
    		 Variable ABnormal morphology family member (vab-19...
    		 16(a)
    		 possible ortholog
    		 II(2443297-2451145)


    ENSEMBL Gene Tree for KANK3 (if available)
    TreeFam Gene Tree for KANK3 (if available) 

    Paralogs
    for KANK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KANK3 gene
    KANK12  KANK22  KANK42  
    10 SIMAP similar genes for KANK3 using alignment to 2 protein entries:     KANK3_HUMAN (see all proteins):
    Kank3    NF2    AURA2    EIF3L    LINC00596    IkBa
    KANK4    FAM175A    PPP1R12A    KANK2

    KANK3 for paralogs           About GeneDecksing



    Genomic Variants
    for KANK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/452 NCBI SNPs in KANK3 are shown (see all 452)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs112600801,2
    		C,A,H,--8042417(+) gggagT/Gtggag 1 -- int11Minor allele frequency- G:0.00NA 4
    rs775022741,2
    		--8042895(+) TGATAA/GGAGCC 1 -- int10--------
    rs744903791,2
    		F,--8043227(+) AGCAGC/TCACAT 1 -- int11Minor allele frequency- T:0.09WA 118
    rs1119778091,2
    		--8044655(+) ACCCGC/TCAAGC 1 -- int12Minor allele frequency- T:0.04CSA WA 120
    rs1112929831,2
    		--8046034(+) GGAGCG/AGGGTC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs574784881,2
    		C,--8046095(+) CTGAGG/AAGTAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs118799591,2
    		C,F,H,--8046774(+) CGTCAG/CGTGGT 1 -- int16Minor allele frequency- C:0.02NS EA NA WA 538
    rs1123181141,2
    		C,--8046988(+) AGTTCG/AAGAAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs360247921,2
    		C,F,--8046990(+) TTCGAG/TAACAG 1 -- int13Minor allele frequency- T:0.33NA 6
    rs1138345651,2
    		--8047582(+) TGAGCC/TGAGAA 1 -- int12Minor allele frequency- T:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for KANK3 (8387468 - 8408146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for KANK3: --

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    Disorders / Diseases
    for KANK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KANK3 for disorders           About GeneDecksing

    OMIM gene information: 614611    OMIM disorders: --

    1 disease for KANK3:    About MalaCards
    neuronitis


    Export disorders for KANK3 gene to outside databases

    Publications
    for KANK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KANK3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KANK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)1, 2, 3 Zhu Y.... Kiyama R. (2008)
    2. Kank proteins: structure, functions and diseases. (PubMed id 19554261)1, 3 Kakinuma N....Kiyama R. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    7. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

    External Searches for KANK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing KANK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 256949 HGNC: 24796 AceView: NDUFA7and8D6AandFLJ46061 Ensembl:ENSG00000186994 euGenes: HUgn256949
    ECgene: KANK3 H-InvDB: KANK3

    Other Databases showing KANK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing KANK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KANK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KANK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KANK3 gene:
    Search GeneIP for patents involving KANK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for KANK3 gene

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    About This Section

     
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