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KANK3 Gene

protein-coding GIFtS: 38

GC19M008297

KN motif and ankyrin repeat domains 3
(Previous name: ankyrin repeat domain 47 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ANKRD47)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ANKRD47 ^², ³
FLJ46061 ^¹, ²

Descriptions
Ankyrin repeat domain-containing protein 47 ^³
KN motif and ankyrin repeat domains 3 ^²
ankyrin repeat domain 47 ^¹, ²
kidney ankyrin repeat-containing protein 3 ^²

External Ids
HGNC: 24796¹
Entrez Gene: 256949²
UniProtKB: Q6NY19³
Ensembl: ENSG00000186994⁷

Search outside databases for aliases for KANK3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

KANK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M008297: (about GC identifiers)

Start:	8,293,468 bp from pter
End:	8,314,146 bp from pter
Size:	20,679 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_077812.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19 (See protein sequence)

Recommended Name: KN motif and ankyrin repeat domain-containing protein 3

Size: 840 amino acids; 88425 Da

Secondary accessions: Q6NZI1 Q6ZQR3 Q8IUV2

Alternative splicing: 2 isoforms: Q6NY19-1 Q6NY19-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_940873.2

ENSEMBL proteins:

ENSP00000370444 ENSP00000328923 ENSP00000352814

Human Recombinant Proteins

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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for KANK3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
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Assays for KANK3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6NY19

ProtoNet protein and cluster: Q6NY19

1 Blocks protein family: IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: KANK3_HUMAN, Q6NY19

Similarity: Contains 5 ANK repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KANK3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198471

Applied Biosystems Silencer® siRNAs for KANK3

Sigma-Aldrich siRNA for KANK3

Sigma-Aldrich shRNA for KANK3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_198471
Myc/DDK tagged cDNA clone in CMV expression vector: NM_198471
untagged cDNA clone in CMV expression vector: NM_198471

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_198471

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KANK3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KANK3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198471

Sigma-Aldrich siRNA for KANK3

Sigma-Aldrich shRNA for KANK3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_198471

REFSEQ mRNAs for KANK3 gene:

NM_198471.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_198471

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198471
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198471
                                 untagged cDNA clone in CMV expression vector: NM_198471

Additional cDNA sequence:

AB284126.1 AK097023.1 AK128815.1 BC035849.2 BC066124.1 BC066775.1

9 DOTS entries:

DT.100685164 DT.102838910 DT.86854456 DT.95334037 DT.99930492 DT.100700773 DT.75156693 DT.451349

DT.99999059

24/537 AceView cDNA sequences (see all 537 ):

CB106682 BE382788 BC035849 BM788886 AA285003 CB141050 CR607353 AJ712866

CB961134 BG164140 CF528604 CD675463 BU165223 CR621881 AA873215 CR603782

BC003102 BQ957623 BQ439279 BU543226 AW024981 AK058014 AI376402 BM453235

Unigene Cluster for KANK3:

KN motif and ankyrin repeat domains 3

Hs.322473 [show with all ESTs]

Unigene Representative Sequence: NM_198471

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000381056 ENST00000330915 ENST00000359768

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KANK3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KANK3

¹ / ²

3 probe-sets matching KANK3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40257_at²	U95-A	1	0.94	1.00	1.00	1.00	--	--	--	--	--
213715_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
213715_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KANK3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.322473

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KANK3 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	KANK3¹	--	KN motif and ankyrin repeat domains 3	85.71(n) 84.1(a)	476723 XM_533927.2 XP_533927.2
chimpanzee (Pan troglodytes)	KANK3¹	--	KN motif and ankyrin repeat domains 3	99.07(n) 98.78(a)	456437 XM_513032.2 XP_513032.2
cow (Bos taurus)	KANK3¹	--	KN motif and ankyrin repeat domains 3	84.2(n) 82.09(a)	509964 XM_587034.3 XP_587034.3
rat (Rattus norvegicus)	Kank3¹	--	KN motif and ankyrin repeat domains 3	79.2(n) 79.24(a)	366848 XM_345803.3 XP_345804.3
mouse (Mus musculus)	Kank3^{1, 5}	17 (18.00 cM)⁵	KN motif and ankyrin repeat domains 3^{1, 5}	77.99(n)¹ 78.33(a)¹	80880¹ NM_030697.2¹ NP_109622.1¹ AA879929⁵ AK002623⁵ (see all 13)

About this table Species with no ortholog for KANK3

ENSEMBL Gene Tree for KANK3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KANK3 gene

KANK2² KANK1² KANK4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/178 NCBI SNPs in KANK3 are shown (see all 178 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2913955^1,2	A,C,F,H	8304975(+)	`GCTGGT/CGTCCT`	1	T/A	mis¹ ese³		3		MN EA	362
	rs890853^1,2	A,C,F	8305635(-)	`GCTGCA/GCGCCA`	1	R/H	mis¹ ese³		1		MN	184
	rs890850^1,2	A,F,H	8305849(-)	`TCCTCG/TACGGG`	1	D/Y	mis¹ ese³		4		EU EA WA	418
--	rs7258466^1,2	A,C	8315074(+)	`actcaC/Tgcctg`	1	--	ng3¹ tfbs³		0	--	--	--	--
	rs1019757^1,2	A,C,F,H	8295520(-)	`ATCCTG/AGACAA`	1	L/L	syn¹		10		EU EA WA NA	1020
	rs710949^1,2	A,C,F	8305628(-)	`GCCAGC/TCTGGA`	1	S/S	syn¹ ese³		1		MN	184
	rs8106699^1,2	C,F,H	8305272(+)	`GTGCCG/ATCTCT`	1	D/D	syn¹ ese³		8		EU EA WA	840
	rs890851^1,2	A,F	8305799(-)	`GTGGCC/TGCCGA`	1	A/A	syn¹ ese³		1		MN	184
	rs12981073^1,2	C,F	8295405(+)	`TCCAGA/GGCGAT`	1	A/A	syn¹ ese³		4		EA NA	216
	rs890852^1,2	A	8305709(-)	`ACCGTG/TGAGGC`	1	V/V	syn¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for KANK3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for KANK3 gene:

Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)^{2, 3} Zhu Y....Kiyama R. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)³ Yu W....Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)³ Andersson B....Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 256949	HGNC: 24796	AceView: NDUFA7and8D6AandFLJ46061	Ensembl:ENSG00000186994	euGenes: HUgn256949
ECgene: KANK3	H-InvDB: KANK3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KANK3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KANK3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KANK3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KANK3		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for KANK3

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KANK3 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for KANK3

Summaries
for KANK3

Genomic Location
for KANK3

Proteins
for KANK3

Protein Domains/
Families
for KANK3

Gene Function
for KANK3

Pathways & Interactions
for KANK3

Drugs & Compounds
for KANK3

Transcripts
for KANK3

Expression
for KANK3

Orthologs
for KANK3

Paralogs
for KANK3

SNPs/Variants
for KANK3

Disorders & Mutations
for KANK3

Medical News
for KANK3

Publications
for KANK3

Search for KANK3

Genome Databases showing KANK3

Other Databases showing KANK3

Specialized Databases showing KANK3

Licensable Technologies
for KANK3

Services
for KANK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KANK3 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor KANK3

Summariesfor KANK3

Genomic Locationfor KANK3

Proteinsfor KANK3

Protein Domains/Familiesfor KANK3

Gene Functionfor KANK3

Pathways & Interactionsfor KANK3

Drugs & Compoundsfor KANK3

Transcriptsfor KANK3

Expression for KANK3

Orthologsfor KANK3

Paralogsfor KANK3

SNPs/Variantsfor KANK3

Disorders & Mutationsfor KANK3

Medical Newsfor KANK3

Publicationsfor KANK3

Search for KANK3

Genome Databases showing KANK3

Other Databases showing KANK3

Specialized Databases showing KANK3

Licensable Technologiesfor KANK3

Servicesfor KANK3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KANK3

Summaries
for KANK3

Genomic Location
for KANK3

Proteins
for KANK3

Protein Domains/
Families
for KANK3

Gene Function
for KANK3

Pathways & Interactions
for KANK3

Drugs & Compounds
for KANK3

Transcripts
for KANK3

Expression
for KANK3

Orthologs
for KANK3

Paralogs
for KANK3

SNPs/Variants
for KANK3

Disorders & Mutations
for KANK3

Medical News
for KANK3

Publications
for KANK3

Licensable Technologies
for KANK3

Services
for KANK3