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Aliases for KANK2 Gene

Aliases for KANK2 Gene

  • KN Motif And Ankyrin Repeat Domains 2 2 3
  • ANKRD25 3 4 6
  • Ankyrin Repeat Domain-Containing Protein 25 3 4
  • Matrix-Remodeling-Associated Protein 3 3 4
  • Matrix-Remodelling Associated 3 2 3
  • SRC-1-Interacting Protein 3 4
  • Ankyrin Repeat Domain 25 2 3
  • SRC1-Interacting Protein 3 4
  • SRC-Interacting Protein 3 4
  • KIAA1518 4 6
  • MXRA3 3 4
  • SIP 3 4
  • KN Motif And Ankyrin Repeat Domain-Containing Protein 2 3
  • Kidney Ankyrin Repeat-Containing Protein 2 3
  • SRC-1 Interacting Protein 3
  • PPKWH 3

External Ids for KANK2 Gene

Previous HGNC Symbols for KANK2 Gene

  • MXRA3
  • ANKRD25

Previous GeneCards Identifiers for KANK2 Gene

  • GC19M011274
  • GC19M010851

Summaries for KANK2 Gene

GeneCards Summary for KANK2 Gene

KANK2 (KN Motif And Ankyrin Repeat Domains 2) is a Protein Coding gene. Diseases associated with KANK2 include palmoplantar keratoderma and woolly hair. An important paralog of this gene is KANK3.

UniProtKB/Swiss-Prot for KANK2 Gene

  • Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).

Gene Wiki entry for KANK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KANK2 Gene

Genomics for KANK2 Gene

Regulatory Elements for KANK2 Gene

Genomic Location for KANK2 Gene

Start:
11,164,267 bp from pter
End:
11,197,791 bp from pter
Size:
33,525 bases
Orientation:
Minus strand

Genomic View for KANK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KANK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KANK2 Gene

Proteins for KANK2 Gene

  • Protein details for KANK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q63ZY3-KANK2_HUMAN
    Recommended name:
    KN motif and ankyrin repeat domain-containing protein 2
    Protein Accession:
    Q63ZY3
    Secondary Accessions:
    • B0I1P4
    • Q3KQZ3
    • Q6GUF5
    • Q9H8S4
    • Q9NUP0
    • Q9P210

    Protein attributes for KANK2 Gene

    Size:
    851 amino acids
    Molecular mass:
    91174 Da
    Quaternary structure:
    • Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1.
    SequenceCaution:
    • Sequence=BAA92081.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96042.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14531.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KANK2 Gene

    Alternative splice isoforms for KANK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KANK2 Gene

Proteomics data for KANK2 Gene at MOPED

Post-translational modifications for KANK2 Gene

No data available for DME Specific Peptides for KANK2 Gene

Domains for KANK2 Gene

Gene Families for KANK2 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • KANK :KN motif and ankyrin repeat domain containing

Protein Domains for KANK2 Gene

Suggested Antigen Peptide Sequences for KANK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q63ZY3

UniProtKB/Swiss-Prot:

KANK2_HUMAN :
  • Q63ZY3
Similarity:
  • Contains 5 ANK repeats.
genes like me logo Genes that share domains with KANK2: view

Function for KANK2 Gene

Molecular function for KANK2 Gene

UniProtKB/Swiss-Prot Function: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500). May be involved in promotion of cell proliferation (By similarity).

Gene Ontology (GO) - Molecular Function for KANK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17476305
genes like me logo Genes that share ontologies with KANK2: view

Phenotypes for KANK2 Gene

GenomeRNAi human phenotypes for KANK2:
genes like me logo Genes that share phenotypes with KANK2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for KANK2 Gene

Localization for KANK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KANK2 Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KANK2 Gene COMPARTMENTS Subcellular localization image for KANK2 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KANK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17476305
GO:0005739 mitochondrion IDA 22371500
genes like me logo Genes that share ontologies with KANK2: view

Pathways for KANK2 Gene

SuperPathways for KANK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KANK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 17476305
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0008285 negative regulation of cell proliferation IDA 17476305
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA 17476305
genes like me logo Genes that share ontologies with KANK2: view

No data available for Pathways by source for KANK2 Gene

Transcripts for KANK2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for KANK2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - -
SP2: -
SP3: - - - - - - - - - - - - - -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: -
SP9:
SP10:

ExUns: 15 ^ 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for KANK2 Gene

GeneLoc Exon Structure for
KANK2
ECgene alternative splicing isoforms for
KANK2

Expression for KANK2 Gene

mRNA expression in normal human tissues for KANK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for KANK2 Gene

SOURCE GeneReport for Unigene cluster for KANK2 Gene Hs.284208

mRNA Expression by UniProt/SwissProt for KANK2 Gene

Q63ZY3-KANK2_HUMAN
Tissue specificity: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular podocytes and mesangial cells (at protein level).
genes like me logo Genes that share expressions with KANK2: view

No data available for mRNA differential expression in normal tissues for KANK2 Gene

Orthologs for KANK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KANK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KANK2 35
  • 96.54 (n)
  • 95.99 (a)
KANK2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KANK2 35
  • 86.88 (n)
  • 89.31 (a)
KANK2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KANK2 35
  • 86.72 (n)
  • 89.89 (a)
KANK2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kank2 35
  • 80.89 (n)
  • 84.62 (a)
Kank2 16
Kank2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KANK2 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KANK2 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kank2 35
  • 80.51 (n)
  • 84.37 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia kank2 35
  • 59.28 (n)
  • 56.18 (a)
zebrafish
(Danio rerio)
Actinopterygii kank2 36
  • 38 (a)
OneToOne
LOC571549 35
  • 62.82 (n)
  • 57.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10249 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vab-19 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
CSA.3164 36
  • 24 (a)
ManyToMany
Species with no ortholog for KANK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KANK2 Gene

ENSEMBL:
Gene Tree for KANK2 (if available)
TreeFam:
Gene Tree for KANK2 (if available)

Paralogs for KANK2 Gene

Paralogs for KANK2 Gene

Selected SIMAP similar genes for KANK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with KANK2: view

Variants for KANK2 Gene

Sequence variations from dbSNP and Humsavar for KANK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7187 -- 11,164,582(-) AAGAG(C/T)TCTGT utr-variant-3-prime
rs7188 -- 11,164,463(-) TACAC(G/T)TCCTT utr-variant-3-prime
rs16423 -- 11,165,136(-) ACTCA(-/CA)GTTTC utr-variant-3-prime
rs370229 -- 11,173,807(-) CAGTC(C/T)AACGA intron-variant
rs379309 -- 11,173,626(-) GAAAC(A/G)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KANK2 Gene

Variant ID Type Subtype PubMed ID
dgv3729n71 CNV Loss 21882294
dgv3730n71 CNV Loss 21882294
nsv911059 CNV Loss 21882294
esv2718172 CNV Deletion 23290073
esv2658280 CNV Deletion 23128226
esv29212 CNV Loss 19812545
nsv911060 CNV Loss 21882294
nsv522449 CNV Loss 19592680
nsv525977 CNV Loss 19592680

Relevant External Links for KANK2 Gene

HapMap Linkage Disequilibrium report
KANK2
Human Gene Mutation Database (HGMD)
KANK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KANK2 Gene

Disorders for KANK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for KANK2 Gene including...

Search for KANK2 Gene in MalaCards »

UniProtKB/Swiss-Prot

KANK2_HUMAN
  • Palmoplantar keratoderma and woolly hair (PPKWH) [MIM:616099]: A disorder characterized by abnormal thickening of the skin on the palms and soles, in association with woolly scalp hair. Affected individuals manifest a variable degree of striate palmoplantar keratoderma, generally more severe on the soles. Leukonychia is more pronounced on the fingernails than toenails. Scalp hair, body hair, eyebrows, and eyelashes are sparse. The fifth toes show variable degrees of pseudoainhum, ranging from external rotation to a deep sulcus at the digitoplantar fold, accompanied by a bulbous appearance of the distal toe. {ECO:0000269 PubMed:24671081}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with KANK2: view

Publications for KANK2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PMID: 17996375) Zhu Y. … Kiyama R. (Biochim. Biophys. Acta 2008) 2 3 4
  3. Kank proteins: structure, functions and diseases. (PMID: 19554261) Kakinuma N. … Kiyama R. (Cell. Mol. Life Sci. 2009) 2 3
  4. Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. (PMID: 22371500) Wang D. … Shang Y. (J. Biol. Chem. 2012) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for KANK2 Gene

  • antibodies-online peptides for KANK2
  • antibodies-online antibodies for KANK2
  • antibodies-online kits for KANK2

Sources for KANK2 Gene

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