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KANK2 Gene

protein-coding   GIFtS: 53
GCID: GC19M011274

KN Motif And Ankyrin Repeat Domains 2

(Previous names: matrix-remodelling associated 3, ankyrin repeat domain 25)
(Previous symbols: MXRA3, ANKRD25)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
KN Motif And Ankyrin Repeat Domains 21 2     SRC-1-Interacting Protein2 3
ANKRD251 2 3 5     SRC-Interacting Protein2 3
MXRA31 2 3     SRC1-Interacting Protein2 3
Ankyrin Repeat Domain 251 2     KIAA15183 5
Matrix-Remodelling Associated 31 2     Kidney Ankyrin Repeat-Containing Protein 22
Ankyrin Repeat Domain-Containing Protein 252 3     KN Motif And Ankyrin Repeat Domain-Containing Protein 22
Matrix-Remodeling-Associated Protein 32 3     SRC-1 Interacting Protein2
SIP2 3     

External Ids:    HGNC: 293001   Entrez Gene: 259592   Ensembl: ENSG000001972567   OMIM: 6146105   UniProtKB: Q63ZY33   

Export aliases for KANK2 gene to outside databases

Previous GC identifers: GC19M011139 GC19M010851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KANK2 Gene:
KANK2 (KN motif and ankyrin repeat domains 2) is a protein-coding gene. An important paralog of this gene is KANK1.

UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
Function: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2
and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of
cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent
apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation
allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation

Gene Wiki entry for KANK2 (ANKRD25) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the KANK2 gene promoter:
         C/EBPbeta   Elk-1   p53   Pax-5   Brachyury   Lmo2   GATA-1   YY1   Evi-1   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKANK2 promoter sequence
   Search Chromatin IP Primers for KANK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KANK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

KANK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KANK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011274:  view genomic region     (about GC identifiers)

Start:
11,274,943 bp from pter      End:
11,308,467 bp from pter
Size:
33,525 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3 (See protein sequence)
Recommended Name: KN motif and ankyrin repeat domain-containing protein 2  
Size: 851 amino acids; 91174 Da
Subunit: Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1
Sequence caution: Sequence=BAA92081.1; Type=Erroneous initiation; Sequence=BAA96042.2; Type=Erroneous initiation;
Sequence=BAB14531.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KANK2:
4HBD (3D)    
Secondary accessions: B0I1P4 Q3KQZ3 Q6GUF5 Q9H8S4 Q9NUP0 Q9P210
Alternative splicing: 3 isoforms:  Q63ZY3-1   Q63ZY3-2   Q63ZY3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KANK2: NX_Q63ZY3

Explore proteomics data for KANK2 at MOPED

Post-translational modifications: 

  • Phosphorylated by CaMK2 upon estrogen stimulation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KANK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129663.1  NP_056308.3  

    ENSEMBL proteins: 
     ENSP00000465650   ENSP00000464896   ENSP00000468002   ENSP00000467029   ENSP00000468409  
     ENSP00000468490   ENSP00000465914   ENSP00000464861   ENSP00000395650   ENSP00000347276  

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    antibodies-online peptides for KANK2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    KANK: KN motif and ankyrin repeat domain containing

    3 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR021939 KN_motif
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q63ZY3

    ProtoNet protein and cluster: Q63ZY3

    UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
    Similarity: Contains 5 ANK repeats


    Find genes that share domains with KANK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KANK2_HUMAN, Q63ZY3
    Function: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2
    and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of
    cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent
    apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation
    allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17476305
         
    Find genes that share ontologies with KANK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KANK2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KANK2

    miRNA
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    miRTarBase miRNAs that target KANK2:
    hsa-mir-106b-5p (MIRT044246), hsa-mir-1 (MIRT023699), hsa-mir-155-5p (MIRT020755), hsa-mir-193b-3p (MIRT016547), hsa-mir-92a-3p (MIRT049313), hsa-mir-26b-5p (MIRT029311), hsa-mir-124-3p (MIRT022589)

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    hsa-miR-579 hsa-miR-3164 hsa-miR-126 hsa-miR-146b-3p hsa-miR-607 hsa-miR-429 hsa-miR-513c hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidKANK2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KANK2_HUMAN, Q63ZY3: Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus3
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17476305
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with KANK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KANK2
    Interactions:

        Search GeneGlobe Interaction Network for KANK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for KANK2 (Q63ZY31, 2, 3 ENSP000003472764) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA1Q157881, 2, 3, ENSP000003209404EBI-2556193,EBI-455189 MINT-4958619 MINT-4958729 MINT-4958705 MINT-4958599 I2D: score=1 STRING: ENSP00000320940
    NCOA3Q9Y6Q92, ENSP000003610664MINT-4958619 MINT-4958650 STRING: ENSP00000361066
    CSNK2A1P684002, 3, ENSP000002172444MINT-4961111 I2D: score=1 STRING: ENSP00000217244
    GRIP1Q9Y3R02, ENSP000003810984MINT-4958619 MINT-4958650 STRING: ENSP00000381098
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17476305
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IDA17476305
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway IDA17476305

    Find genes that share ontologies with KANK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KANK2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KANK2 gene (2 alternative transcripts): 
    NM_001136191.2  NM_015493.6  

    Unigene Cluster for KANK2:

    KN motif and ankyrin repeat domains 2
    Hs.284208  [show with all ESTs]
    Unigene Representative Sequence: BE896143
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586659 ENST00000588787 ENST00000587317 ENST00000589359 ENST00000589894
    ENST00000590400 ENST00000592675 ENST00000590685 ENST00000588724 ENST00000592903
    ENST00000592215 ENST00000590095 ENST00000589427 ENST00000432929(uc002mqm.3 uc021upe.1 uc002mqo.4)
    ENST00000355150(uc002mqp.1 uc002mqq.3)
    miRNA
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    hsa-miR-579 hsa-miR-3164 hsa-miR-126 hsa-miR-146b-3p hsa-miR-607 hsa-miR-429 hsa-miR-513c hsa-miR-199b-5p
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    Additional mRNA sequence: CR457388.1 

    3 DOTS entries:

    DT.100796945  DT.418172  DT.95258828 

    Selected AceView cDNA sequences (see all 291):

    BX281094 F04796 H71470 CF529080 AI275186 AI911337 AA485660 BQ212115 
    AI492474 AA488007 AU133959 AI282589 CR595669 AA599312 BQ943269 W74274 
    AI753611 AL709703 BF063688 W84510 AA908660 C01927 AW069414 CA390600 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for KANK2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                                -     -     -                                                           -                                               -   
    SP2:                                                                                                                                                        -   
    SP3:              -     -     -     -     -     -                       -     -     -     -     -     -     -     -                                             
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -     -           -                                                   

    ExUns: 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for KANK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KANK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCTTTAATT
    KANK2 Expression
    About this image


    KANK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Brain (Nervous System)
             Cerebellum
    KANK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KANK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.284208

    UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
    Tissue specificity: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular
    podocytes and mesangial cells (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KANK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Kank21 , 5 KN motif and ankyrin repeat domains 21, 5 80.89(n)1
    84.62(a)1
      9 (7.88 cM)5
    2350411  NM_145611.41  NP_663586.31 
     217667735 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    1 → many
    2(79592097-79611060)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC049177.12   -- 78.62(n)    BC049177.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056795.12   -- 77.51(n)    BC056795.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102496
    --
    17(a)
    1 → many
    2R(10788980-10815930)
    worm
    (Caenorhabditis elegans)
    Secernentea vab-196
    Protein VAB-19 (vab-19) mRNA, complete cds
    19(a)
    1 → many
    II(2443292-2451140) WBGene00006882


    ENSEMBL Gene Tree for KANK2 (if available)
    TreeFam Gene Tree for KANK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KANK2 gene
    KANK12  KANK42  KANK32  
    7 SIMAP similar genes for KANK2 using alignment to 5 protein entries:     KANK2_HUMAN (see all proteins):
    hKank-L    DKFZp666N084    KANK1    KANK4    ANKRD6    KANK3
    Kank3

    Find genes that share paralogs with KANK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KANK2 (see all 1032)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs72578161,2
    C,F--11274445(+) gtggcG/Acagcc 2 -- int18Minor allele frequency- A:0.29NA WA CSA EA 368
    rs790507091,2
    C,F--11274530(+) TGATTC/TGCACC 2 -- int12Minor allele frequency- T:0.09NA 122
    rs1123858261,2
    C,F--11274585(+) AAAAGT/CGGTGG 2 -- int12Minor allele frequency- C:0.06CSA WA 120
    rs1480795811,2
    --11274668(+) GCCTGA/CCCAAC 2 -- int10--------
    rs104693641,2
    C,F,A--11274679(+) atagcG/Aaaacc 2 -- int19Minor allele frequency- A:0.29NA WA CSA EA 254
    rs1438139751,2
    C--11274722(+) GTGTGA/GTGGGC 2 -- int10--------
    rs1132732201,2
    C,F--11274727(+) GTGGGC/TACCTG 2 -- int12Minor allele frequency- T:0.06CSA WA 120
    rs65117261,2
    C,F--11274728(+) tgggcG/Acctgt 2 -- int112Minor allele frequency- A:0.34NA WA CSA EA 375
    rs46005741,2
    C,F,A,H--11274876(+) agaaaC/Aaaaaa 2 -- int120Minor allele frequency- A:0.34EA NS NA WA CSA 1738
    rs1845087601,2
    --11274880(+) AAAAAA/GAAGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for KANK2 (11274943 - 11308467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for KANK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718172CNV Deletion23290073
    esv2658280CNV Deletion23128226
    nsv522449CNV Loss19592680
    nsv911060CNV Loss21882294
    dgv3730n71CNV Loss21882294
    nsv525977CNV Loss19592680
    esv29212CNV Loss19812545
    dgv3729n71CNV Loss21882294
    nsv911059CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KANK2
    DNA2.0 Custom Variant and Variant Library Synthesis for KANK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614610    OMIM disorders: --


    Find genes that share disorders with KANK2           About GenesLikeMe


    Export disorders for KANK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KANK2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with KANK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)1, 2, 3 Zhu Y.... Kiyama R. (Biochim. Biophys. Acta 2008)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Kank proteins: structure, functions and diseases. (PubMed id 19554261)1, 3 Kakinuma N....Kiyama R. (Cell. Mol. Life Sci. 2009)
    4. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. (PubMed id 17476305)1, 2 Zhang Y.... Shang Y. (EMBO J. 2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PubMed id 23505323)1 Weissglas-Volkov D....Pajukanta P. (J. Med. Genet. 2013)
    9. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25959 HGNC: 29300 AceView: ANKRD25 Ensembl:ENSG00000197256 euGenes: HUgn25959
    ECgene: KANK2 H-InvDB: KANK2

    (According to HUGE)
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    HUGE: KIAA1518

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KANK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KANK2 gene:
    Search GeneIP for patents involving KANK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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