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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KANK2 Gene

protein-coding   GIFtS: 50
GCID: GC19M011274

KN motif and ankyrin repeat domains 2

(Previous names: matrix-remodelling associated 3, ankyrin repeat domain...)
(Previous symbols: MXRA3, ANKRD25)
 Explore 2 diseases affiliated with
KANK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for KANK2    

Aliases
for KANK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
KN Motif And Ankyrin Repeat Domains 21 2     SIP2 3
ANKRD251 2 3     SRC-1-Interacting Protein2 3
MXRA31 2 3     SRC-Interacting Protein2 3
Ankyrin Repeat Domain 251 2     SRC1-Interacting Protein2 3
Matrix-Remodelling Associated 31 2     Kidney Ankyrin Repeat-Containing Protein 22
KIAA15181 3     KN Motif And Ankyrin Repeat Domain-Containing Protein 22
Ankyrin Repeat Domain-Containing Protein 252 3     SRC-1 Interacting Protein2
Matrix-Remodeling-Associated Protein 32 3     

External Ids:    HGNC: 293001   Entrez Gene: 259592   Ensembl: ENSG000001972567   OMIM: 6146105   UniProtKB: Q63ZY33   

Export aliases for KANK2 gene to outside databases

Previous GC identifers: GC19M011139 GC19M010851


Summaries
for KANK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
Function: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and
NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of
cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis;
proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the
release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation

Gene Wiki entry for KANK2 (ANKRD25)


Genomic Views
for KANK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KANK2 gene promoter:
         C/EBPbeta   Elk-1   p53   Pax-5   Brachyury   Lmo2   GATA-1   YY1   Evi-1   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KANK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KANK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KANK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

KANK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KANK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M011274:  view genomic region     (about GC identifiers)

Start:
 11,274,943 bp from pter      End:
 11,308,467 bp from pter
Size:
 33,525 bases      Orientation:
 minus strand

Proteins
for KANK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3 (See protein sequence)
Recommended Name: KN motif and ankyrin repeat domain-containing protein 2  
Size: 851 amino acids; 91174 Da
Subunit: Interacts (phosphorylated) with NCOA1; NCOA2 AND NCOA3. Interacts with AIFM1
Subcellular location: Cytoplasm. Mitochondrion
Sequence caution: Sequence=BAA92081.1; Type=Erroneous initiation; Sequence=BAA96042.2; Type=Erroneous initiation;
Sequence=BAB14531.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for KANK2:
4HBD (3D)    
Secondary accessions: B0I1P4 Q3KQZ3 Q6GUF5 Q9H8S4 Q9NUP0 Q9P210
Alternative splicing: 3 isoforms:  Q63ZY3-1   Q63ZY3-2   Q63ZY3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KANK2: NX_Q63ZY3

Post-translational modifications:

  • Phosphorylated by CaMK2 upon estrogen stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q63ZY3

    • KANK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129663.1  NP_056308.3  

    ENSEMBL proteins: 
     ENSP00000465650   ENSP00000464896   ENSP00000468002   ENSP00000467029   ENSP00000468409  
     ENSP00000468490   ENSP00000465914   ENSP00000464861   ENSP00000395650   ENSP00000347276  

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    Uscn Proteins for KANK2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17476305
    GO:0005739mitochondrion IDA--


    KANK2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for KANK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    KANK2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002110 Ankyrin_rpt
     IPR021939 KN_motif
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q63ZY3

    ProtoNet protein and cluster: Q63ZY3

    UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
    Similarity: Contains 5 ANK repeats


    Function
    for KANK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
    Function: Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and
    NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of
    cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis;
    proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the
    release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation

    miRNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    KANK2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for KANK2:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for KANK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KANK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for KANK2 (Q63ZY31, 2, 3 ENSP000003472764) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOA1Q157882, 3, ENSP000003209404MINT-4958619 MINT-4958729 MINT-4958705 MINT-4958599 I2D: score=1 STRING: ENSP00000320940
    NCOA3Q9Y6Q92, ENSP000003610664MINT-4958619 MINT-4958650 STRING: ENSP00000361066
    CSNK2A1P684002, 3, ENSP000002172444MINT-4961111 I2D: score=1 STRING: ENSP00000217244
    GRIP1Q9Y3R02, ENSP000003810984MINT-4958619 MINT-4958650 STRING: ENSP00000381098
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA17476305
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006915apoptotic process IEA--
    GO:0008285negative regulation of cell proliferation IDA17476305
    GO:0033147negative regulation of intracellular estrogen receptor signaling pathway IDA17476305


    KANK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for KANK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KANK2
    Search CenterWatch for drugs/clinical trials and news about KANK2 

    Transcripts
    for KANK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for KANK2 gene (2 alternative transcripts): 
    NM_001136191.2  NM_015493.6  

    Unigene Clusters for KANK2:

    KN motif and ankyrin repeat domains 2
    Hs.284208  [show with all ESTs], Hs.723365
    Unigene Representative Sequences: AB284125, BC019078
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586659 ENST00000588787 ENST00000587317 ENST00000589359 ENST00000589894
    ENST00000590400 ENST00000592675 ENST00000590685 ENST00000588724 ENST00000592903
    ENST00000592215 ENST00000590095 ENST00000589427 ENST00000432929(uc002mqm.3 uc021upe.1 uc002mqo.4)
    ENST00000355150(uc002mqp.1 uc002mqq.3)

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    hsa-miR-579 hsa-miR-3164 hsa-miR-126 hsa-miR-146b-3p hsa-miR-607 hsa-miR-429 hsa-miR-513c hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmid: KANK2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: BC019078.2 

    17 DOTS entries:

    DT.100796945  DT.418172  DT.95258828  DT.91737339  DT.121475625  DT.91746547  DT.121475644  DT.97842021 
    DT.95248411  DT.91986651  DT.121475473  DT.121475528  DT.121475562  DT.91691142  DT.121475517  DT.121475551 
    DT.95116477 

    24/291 AceView cDNA sequences (see all 291):

    W84510 AI492474 AI701411 C01927 AK002094 BQ212115 AA488007 AW499863 
    AA919076 AI753611 BQ941266 BX281094 AU133425 AI282589 AA908660 BC082762 
    AI275186 AL709703 BF726139 AI628677 AI911337 H71470 AA487895 BF063688 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KANK2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
    SP1:                                -     -     -                                                           -                                               -   
    SP2:                                                                                                                                                        -   
    SP3:              -     -     -     -     -     -                       -     -     -     -     -     -     -     -                                             
    SP4:                                                                                                                                                            
    SP5:              -     -     -     -     -     -     -     -     -     -     -     -     -     -           -                                                   

    ExUns: 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for KANK2

    Expression
    for KANK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KANK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCTTTAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See KANK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KANK2

    SOURCE GeneReport for Unigene clusters: Hs.284208 Hs.723365

    UniProtKB/Swiss-Prot: KANK2_HUMAN, Q63ZY3
    Tissue specificity: Strongly expressed in cervix, colon, heart, kidney and lung. Expressed in kidney glomerular
    podocytes and mesangial cells (at protein level)

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    In Situ
    Assay Products:     
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    Orthologs
    for KANK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for KANK2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Kank21 , 5 KN motif and ankyrin repeat domains 21, 5 80.89(n)1
    84.62(a)1    		   9 (7.88 cM)5
    2350411  NM_145611.41  NP_663586.31 
     217667735 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 61(a)
    38(a)
    		 many → 1
    many → 1
    		 AAWZ02040193(4326-6188)
    2(79592097-79611060)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC049177.12   -- 78.62(n)    BC049177.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC056795.12   -- 77.51(n)    BC056795.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG102496
    		 --
    		 14(a)
    		 1 → many
    		 2R(10788980-10815930)
    worm
    (Caenorhabditis elegans)    		 Secernentea vab-196
    		 Variable ABnormal morphology family member (vab-19...
    		 16(a)
    		 possible ortholog
    		 II(2443297-2451145)


    ENSEMBL Gene Tree for KANK2 (if available)
    TreeFam Gene Tree for KANK2 (if available) 

    Paralogs
    for KANK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KANK2 gene
    KANK12  KANK42  KANK32  
    7 SIMAP similar genes for KANK2 using alignment to 5 protein entries:     KANK2_HUMAN (see all proteins):
    hKank-L    DKFZp666N084    KANK1    KANK4    ANKRD6    KANK3
    Kank3

    KANK2 for paralogs           About GeneDecksing



    Genomic Variants
    for KANK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/829 NCBI SNPs in KANK2 are shown (see all 829)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs72578161,2
    		C,F,--11274445(+) GTGGCG/ACAGCC 2 -- int18Minor allele frequency- A:0.29NA WA CSA EA 368
    rs790507091,2
    		C,--11274530(+) TGATTC/TGCACC 2 -- int12Minor allele frequency- T:0.09NA 122
    rs1123858261,2
    		--11274585(+) AAAAGT/CGGTGG 2 -- int12Minor allele frequency- C:0.06CSA WA 120
    rs1480795811,2
    		--11274668(+) GCCTGA/CCCAAC 2 -- int10--------
    rs104693641,2
    		C,F,A,--11274679(+) ATAGCG/AAAACC 2 -- int19Minor allele frequency- A:0.29NA WA CSA EA 254
    rs1438139751,2
    		--11274722(+) GTGTGA/GTGGGC 2 -- int10--------
    rs1132732201,2
    		--11274727(+) GTGGGC/TACCTG 2 -- int12Minor allele frequency- T:0.06CSA WA 120
    rs65117261,2
    		C,F,--11274728(+) TGGGCG/ACCTGT 2 -- int112Minor allele frequency- A:0.34NA WA CSA EA 375
    rs46005741,2
    		C,F,A,H,--11274876(+) AGAAAC/AAAAAA 2 -- int120Minor allele frequency- A:0.34EA NS NA WA CSA 1738
    rs1845087601,2
    		--11274880(+) AAAAAA/GAAGGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for KANK2 (11274943 - 11308467 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for KANK2
         1 CNV: 67466

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    Disorders / Diseases
    for KANK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    KANK2 for disorders           About GeneDecksing

    OMIM gene information: 614610    OMIM disorders: --

    2 diseases for KANK2:    About MalaCards
    choroiditis    neuronitis


    Export disorders for KANK2 gene to outside databases

    Publications
    for KANK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KANK2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with KANK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375)1, 2, 3 Zhu Y.... Kiyama R. (2008)
    2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Kank proteins: structure, functions and diseases. (PubMed id 19554261)1, 3 Kakinuma N....Kiyama R. (2009)
    4. SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm. (PubMed id 17476305)1, 2 Zhang Y....Shang Y. (2007)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria. (PubMed id 22371500)2 Wang D....Shang Y. (2012)

    External Searches for KANK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing KANK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25959 HGNC: 29300 AceView: ANKRD25 Ensembl:ENSG00000197256 euGenes: HUgn25959
    ECgene: KANK2 H-InvDB: KANK2

    Other Databases showing KANK2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1518

    Specialized Databases showing KANK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KANK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for KANK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for KANK2 gene:
    Search GeneIP for patents involving KANK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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