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Aliases & Descriptions for KANK1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ANKRD15 2 , 3 DKFZp451G231 2 KANK 1 , 2 , 3 KIAA0172 1 , 2 , 3 MGC43128 2 OTTHUMP00000020957 2 OTTHUMP00000082438 2 OTTHUMP00000082439 2
Descriptions Ankyrin repeat domain-containing protein 15 3 KN motif and ankyrin repeat domains 1 2 Kidney ankyrin repeat-containing protein 2 , 3 ankyrin repeat domain 15 1 , 2
Search outside databases for aliases for KANK1 gene
Summaries for KANK1 (According to Entrez Gene ,
Wikipedia's
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UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for KANK1 : This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggestedrole for this protein is in tumorigenesis of renal cell carcinoma. Two alternatively splicedtranscript variants encoding different isoforms have been identified. [provided by RefSeq] UniProtKB/Swiss-Prot: KANK1_HUMAN, Q14678 Function : Potential tumor suppressor for renal cell carcinoma
Gene Wiki entry for KANK1 (ANKRD15)
Genomic Location for KANK1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9p24.3 Ensembl cytogenetic band: 9p24.3 HGNC cytogenetic band: 9p24.3 KANK1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P000461:
(about GC identifiers )
Start:
460,291 bp from pter
End:
736,105 bp from pter
Size:
275,815 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000009.10 NT_008413.17 Proteins for KANK1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: KANK1_HUMAN, Q14678 (See
protein sequence )Recommended Name: KN motif and ankyrin repeat domain-containing protein 1 Size : 1352 amino acids; 147289 Da
Subcellular location : Cytoplasm
Secondary accessions : Q5W0W0 Q8IY65 Q8WX74
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_055973.2 NP_694856.1 ENSEMBL proteins: ENSP00000371723 ENSP00000371726 ENSP00000381063 ENSP00000223950 ENSP00000371730 ENSP00000346479 ENSP00000371740 ENSP00000371734 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
About this table Antibodies for KANK1: Assays for KANK1:
Protein
Domains/ Families for KANK1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q14678 ProtoNet protein and cluster: Q14678
1 Blocks protein family : IPB002110 Ankyrin repeat signature UniProtKB/Swiss-Prot: KANK1_HUMAN, Q14678 Similarity : Contains 5 ANK repeats
Gene Function for KANK1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_153186 Applied Biosystems Silencer ® siRNAs for KANK1 Sigma-Aldrich siRNA for KANK1 Sigma-Aldrich shRNA for KANK1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015158                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015158                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_015158  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015158 UniProtKB/Swiss-Prot: KANK1_HUMAN, Q14678 Function : Potential tumor suppressor for renal cell carcinoma
Pathways & Interactions for KANK1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for KANK1 (ENSP00000371740 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0045786 negative regulation of cell cycle
IEA --
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Drugs & Compounds for KANK1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for KANK1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_153186 Sigma-Aldrich siRNA for KANK1 Sigma-Aldrich shRNA for KANK1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015158 NM_153186
REFSEQ mRNAs for KANK1 gene (2 alternative transcripts): NM_015158.2 NM_153186.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015158 NM_153186
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015158                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015158                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_015158  
Additional cDNA sequence: AB205106.1 AB205107.1 AB205108.1 AB205109.1 AB205110.1 AB205111.1 AB205113.1 AK025097.1 AK025428.1 AK025636.1 AK026421.1 AK290028.1 AK292989.1 AK311119.1 AL833015.1 AL833082.1 AL833161.1 BC020040.1 BC037495.2 BC038116.2 BX640745.1 BX648931.1 CR594759.1 D79994.2
24/34 DOTS entries (see all 34
): DT.446770 DT.97842681 DT.100027583 DT.95142104 DT.102826417 DT.100780440 DT.97820165 DT.100027580 DT.121171153 DT.40130834 DT.95195177 DT.121170911 DT.121171079 DT.438026 DT.70101158 DT.92019750 DT.95153277 DT.97787843 DT.100742805 DT.100780442 DT.121171135 DT.100651730 DT.100742804 DT.121170929
24/207 AceView cDNA sequences (see all 207
):BF002723 AI684073 BU626132 AA677433 AW079408 AI096574 BX100237 AL110404 BF196842 AI373524 AA968780 AA649052 AA918565 AW591585 AA761856 BM826271 NM_153186 CA777772 BI020436 BM672808 AA470724 AW341277 AI470967 NM_015158
Unigene Cluster for KANK1: KN motif and ankyrin repeat domains 1 Hs.306764 [show with all ESTs ] Unigene Representative Sequence: BX640745 GeneLoc Exon Structure 5/21 Alternative Splicing Database (ASD) splice patterns (SP) for KANK1 (see all 21
) ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · SP1 :                                                     SP2 :                                                     SP3 :                                                     SP4 :         -   -   -   -   -   -   -   -   -   -   -   -   -   -   -     -   -   -   -   -   -   SP5 :       -         -   -   -   -                                
ExUns: 16b ^ 17a · 17b ^ 18a · 18b · 18c · 18d · 18e · 18f · 18g · 18h · 18i · 18j ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b SP1 :                                                 SP2 :                                                 SP3 :                                                 SP4 : -                                                 SP5 :                                                
About this scheme ECgene alternative splicing isoforms for KANK1 8 Ensembl transcripts including schematic representations : ENST00000382286
ENST00000382289
ENST00000397976
ENST00000223950
ENST00000382293
ENST00000354485
ENST00000382303
ENST00000382297
Expression for KANK1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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KANK1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for KANK1 1 / 2
11 probe-sets matching KANK1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAGAACTACASOURCE GeneReport for Unigene cluster: Hs.306764
Orthologs for KANK1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for KANK1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for KANK1 ENSEMBL Gene Tree for KANK1 Paralogs for KANK1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for KANK1 gene KANK2 2 KANK4 2 KANK3 2
SNPs/Variants for KANK1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for KANK1 (up to first 250kb)
Disorders & Mutations for KANK1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607704
Medical News for KANK1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for KANK1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for KANK1 gene (see all 14
): A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma. (PubMed id 12133830) 1, 2, 3, 4 Sarkar S.... Kiyama R. (2002) Kank proteins: a new family of ankyrin-repeat domain-containing proteins. (PubMed id 17996375) 2, 3 Zhu Y....Kiyama R. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 3, 4 Humphray S.J.... Dunham I. (2004) Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849) 3, 4 Nagase T....Nomura N. (1996) Pathological characterization of Kank in renal cell carcinoma. (PubMed id 15596059) 1, 3 Roy B.C....Kiyama R. (2005) Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling. (PubMed id 18458160) 3 Kakinuma N....Kiyama R. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin. (PubMed id 16968744) 3 Wang Y....Kiyama R. (2006) Alternative splicing of the human Kank gene produces two types of Kank protein. (PubMed id 15823577) 3 Wang Y.... Kiyama R. (2005)
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Genome Databases showing KANK1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing KANK1
(According to HUGE )
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Specialized Databases showing KANK1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for KANK1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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