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JUP Gene

protein-coding GIFtS: 68

GC17M037164

junction plakoglobin
(Previous names: catenin (cadherin-associated protein), gamma 80kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CTNNG)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARVD12 ^², ⁵
CTNNG ^², ³
DP3 ^¹, ², ³, ⁵
DPIII ^¹, ²
Desmoplakin-3 ^³
OTTHUMP00000164735 ^²
PDGB ^¹, ², ⁵
PKGB ^¹, ²
gamma-catenin ^²

Descriptions
Catenin gamma ^³
Desmoplakin III ^³
catenin (cadherin-associated protein), gamma (80kD) ^²
catenin (cadherin-associated protein), gamma 80kDa ^¹, ²
junction plakoglobin ^²

External Ids
HGNC: 6207¹
Entrez Gene: 3728²
UniProtKB: P14923³
Ensembl: ENSG00000173801⁷

Search outside databases for aliases for JUP gene

Previous GC identifers: GC17M039465 GC17M041960 GC17M039820 GC17M040284

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for JUP:

This gene encodes a major cytoplasmic protein which is the only known constituent common to

submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct

complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it

contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene

has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all

transcripts have been fully described. [provided by RefSeq]

UniProtKB/Swiss-Prot: PLAK_HUMAN, P14923

Function: Common junctional plaque protein. The membrane-associated plaques are architectural

elements in an important strategic position to influence the arrangement and function of both the

cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes

and in the intermediate junctions suggests that it plays a central role in the structure and

function of submembranous plaques

Gene Wiki entry for JUP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the JUP gene

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21

JUP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M037164: (about GC identifiers)

Start:	37,164,382 bp from pter
End:	37,196,476 bp from pter
Size:	32,095 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PLAK_HUMAN, P14923 (See protein sequence)

Recommended Name: Junction plakoglobin

Size: 745 amino acids; 81745 Da

Subunit: Homodimer. Interacts with MUC1

Subcellular location: Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm,

cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and

membrane-associated form

Sequence caution: Sequence=AAH00441.2; Type=Erroneous initiation; Note=Translation N-terminally

shortened;

Secondary accessions: Q15093 Q15151 Q7L3S5 Q86W21 Q9BWC4 Q9HCX9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002221.1 NP_068831.1

ENSEMBL proteins:

ENSP00000377508 ENSP00000377507 ENSP00000311113

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (gamma Catenin)
	Human Recombinant Proteins from Abnova (JUP)

OriGene Purified Recombinant Human Protein: JUP

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	1639850
GO:0005625	soluble fraction	TAS	1639850
GO:0005737	cytoplasm	TAS	1639850
GO:0005829	cytosol	IEA	--
GO:0005916	fascia adherens	IEA	--

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Antibodies for JUP:

	Invitrogen Antibodies for JUP
	Millipore Mono- and Polyclonal Antibodies for the study of JUP
	Sigma-Aldrich Antibody Arrays and Antibodies for JUP
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for JUP (_-Catenin)
	Antibodies from Abcam (gamma Catenin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JUP)
	Novus Biologicals Antibodies for JUP

Assays for JUP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P14923

ProtoNet protein and cluster: P14923

2 Blocks protein families:

IPB000225 Armadillo repeat

IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: PLAK_HUMAN, P14923

Similarity: Belongs to the beta-catenin family

Similarity: Contains 9 ARM repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JUP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JUP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002230

Applied Biosystems Silencer® siRNAs for JUP

Sigma-Aldrich siRNA and siRNA Panels for JUP

Sigma-Aldrich shRNA Panels and shRNA for JUP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for JUP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002230
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002230
untagged cDNA clones in CMV expression vector (see all 3): NM_002230

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021991

UniProtKB/Swiss-Prot: PLAK_HUMAN, P14923

Function: Common junctional plaque protein. The membrane-associated plaques are architectural

elements in an important strategic position to influence the arrangement and function of both the

cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes

and in the intermediate junctions suggests that it plays a central role in the structure and

function of submembranous plaques

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Jup):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
liver/biliary system	muscle	skin/coat/nails

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008092	cytoskeletal protein binding	TAS	1639850
GO:0019903	protein phosphatase binding	IPI	8663237

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for JUP (Your Favorite Gene powered by Ingenuity)

Acute Myeloid Leukemia Signaling
Germ Cell-Sertoli Cell Junction Signaling

GeneDecks JUP for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for JUP

5/69 Interacting proteins for JUP (ENSP00000311113³ P14923^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 69 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PECAM1	P16284¹	STRING (score=.884) EBI-702484, EBI-716404
PSEN1	P49768¹	STRING (score=.961) EBI-702484, EBI-297277
TCF7L2	Q9NQB0¹	STRING (score=.999) EBI-702484, EBI-924724
CTNNBIP1	Q9NSA3¹^,²	EBI-702484, EBI-747082 MINT-68465 EBI-702484, EBI-747082 MINT-68465
PHB2	Q99623¹	EBI-702484, EBI-358348

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JUP
8 Novoseek chemical compound relationships for JUP gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	49.15	70	11710913 (6), 11371122 (5), 14517306 (4), 11777936 (3) (see all 31)
phosphotyrosine	34.77	2	9378757 (1)
ryanodine	12.56	3	11716909 (1), 19205777 (1)
phalloidin	9.52	1	10075198 (1)
p002	3.85	2	15916880 (1), 16445817 (1)
oligonucleotide	0.00	4	9476558 (2)
sucrose	0.00	2	9645942 (1), 11710948 (1)
calcium	0.00	13	19348003 (3), 8427818 (2), 8636221 (1), 12823304 (1) (see all 7)

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1 PharmGKB drug compound relationship for JUP gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antiarrhythmics	FA GN	12373648

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JUP)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JUP)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002230

Sigma-Aldrich siRNA and siRNA Panels for JUP

Sigma-Aldrich shRNA Panels and shRNA for JUP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002230 NM_021991

REFSEQ mRNAs for JUP gene (2 alternative transcripts):

NM_002230.2 NM_021991.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002230 NM_021991

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002230
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002230
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002230

Additional cDNA sequence:

AK226051.1 AY243535.1 BC000441.2 CR608656.1 CR612481.1 M23410.1 Z68228.1

19 DOTS entries:

DT.316762 DT.95310616 DT.92451789 DT.95353325 DT.95148127 DT.95222134 DT.97862399 DT.100797760

DT.100797771 DT.95329446 DT.100797766 DT.87014380 DT.92451794 DT.95142885 DT.100797763 DT.120971183

DT.40133252 DT.92451791 DT.99945191

24/610 AceView cDNA sequences (see all 610 ):

BM713364 BQ268292 BQ687452 BM757209 CA489074 AW006928 AW298122 BU190718

BQ690879 AA932199 BQ686131 BM672741 BX090907 BF917930 AA777981 BM788177

BE886836 BE857137 BM849198 BQ689724 BM742941 BQ268357 AI763184 BM845779

highest scoring ESTs for JUP:

M23410 AL549599 AW248439 BC000441 BE018649 BE732335 BF313510 BI091479 BI524026 BM547783

Unigene Cluster for JUP:

Junction plakoglobin

Hs.514174 [show with all ESTs]

Unigene Representative Sequence: NM_002230

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for JUP (see all 13 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	·	2f	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13	^
SP1:											-		-		-		-		-		-		-				-
SP2:			-		-		-		-		-		-		-		-		-		-		-				-
SP3:
SP4:											-		-		-		-		-		-		-				-								-		-		-		-		-
SP5:																											-

ExUns:	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21
SP1:							-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for JUP

3 Ensembl transcripts including schematic representations:

ENST00000393931 ENST00000393930 ENST00000310706

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JUP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JUP

¹ / ² / ³

3 probe-sets matching JUP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2047_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M23410	1.00	1.00	1.00	1
201015_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_021991	0.60	1.00	0.82	1
201015_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks JUP for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGTGGGGGG

SOURCE GeneReport for Unigene cluster: Hs.514174
Expression variation in blood from EXPOLDB for JUP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JUP gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JUP¹	--	junction plakoglobin	91.8(n) 99.06(a)	480522 XM_845346.1 XP_850439.1
cow (Bos taurus)	JUP¹	--	junction plakoglobin	92.89(n) 98.26(a)	445543 NM_001004024.1 NP_001004024.1
rat (Rattus norvegicus)	Jup¹	--	junction plakoglobin	90.02(n) 97.99(a)	81679 NM_031047.2 NP_112309.2
mouse (Mus musculus)	Jup^{1, 5}	11 (60.00 cM)⁵	junction plakoglobin^{1, 5}	89.66(n)¹ 98.39(a)¹	16480¹ NM_010593.1¹ NP_034723.1¹ AA277770⁵ AK086401⁵ (see all 15)
zebrafish (Danio rerio)	LOC100003455¹	--	similar to junction plakoglobin	71.6(n) 74.59(a)	100003455 XM_001342986.2 XP_001343022.2

About this table Species with no ortholog for JUP

ENSEMBL Gene Tree for JUP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JUP gene

CTNNB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/219 NCBI SNPs in JUP are shown (see all 219 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 60)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7216371^1,2	A,C,F,H	37197447(+)	`GACCAC/TCAAAC`	2	--	ng3¹		7		EU EA WA NA	554
	rs8074883^1,2	A,C,F,H	37164853(+)	`TGGTCG/AGTGGA`	2	--	ut3¹ ese³		6		EU EA NA	438
	rs9903101^1,2	A,C,F,H	37164211(+)	`CGCATG/ATTGGG`	2	--	ng5¹		4		EU EA WA	406
	rs9902034^1,2	A,C,F,H	37164057(+)	`CATTAA/CGCACG`	2	--	ng5¹		4		EU EA WA	400
	rs2353021^1,2	C,F,H	37198032(+)	`TCAGAA/GAGAAC`	2	--	ng3¹ tfbs³		7		EU EA WA NA	534
	rs8071562^1,2	A,C,F	37164304(+)	`GGACCA/CGCAGG`	2	--	ng5¹		3		NA	140
--	rs4796702^1,2	A,C	37196445(+)	`CGGCGC/TGGTCG`	2	--	ut5¹ ese³		0	--	--	--	--
--	rs7210975^1,2	A,C	37197705(+)	`tttggA/Gaggca`	2	--	ng3¹		0	--	--	--	--
	rs4627408^1,2	A	37165297(+)	`TGCCCA/GCCACC`	2	--	ut3¹ int¹		0	--	--	--	--
--	rs1126821^1,2	F	37165671(-)	`CAGACT/ATGGAT`	2	L/M	mis¹		5		MN EU EA WA	458

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HapMap Linkage Disequilibrium images for JUP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 173325 disorders: 601214 611528

UniProtKB/Swiss-Prot: PLAK_HUMAN, P14923

Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal

recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with

arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair

Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type

12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy type 12

(ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the

myocardium of the right ventricle, electrical instability, and sudden death. It is clinically

defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of

ventricular myocardium with fatty and fibrous elements, preferentially involve the right

ventricular free wall

10/94 Novoseek disease relationships for JUP gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
naxos disease	89.21	14	15851108 (3), 10902626 (2), 11691526 (2), 16096717 (1) (see all 10)
arrhythmogenic right ventricular dysplasia	81.13	14	16893920 (2), 10902626 (1), 17413274 (1), 17924338 (1) (see all 11)
pemphigus vulgaris	76.05	12	9521500 (3), 12358812 (3), 11125324 (1), 7738346 (1) (see all 8)
acantholysis	75.94	5	11553312 (2), 11125324 (1), 12358812 (1), 11334462 (1)
keratoderma palmoplantar	73.63	8	10902626 (2), 17045679 (2), 18957847 (1), 16414451 (1) (see all 6)
hailey-hailey disease	63.22	4	9521500 (3), 1419753 (1)
pemphigus	63.12	4	10427986 (1), 1419753 (1), 11251577 (1)
familial adenomatous polyposis	61.21	7	10408833 (1), 10207085 (1), 11407474 (1), 10996845 (1) (see all 7)
darier disease	60.19	5	9521500 (3), 7537767 (1), 1419753 (1)
metastasis	53.67	41	12658921 (3), 9552044 (2), 15484291 (2), 16288849 (2) (see all 28)

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2 PharmGKB disease relationships for JUP gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Cardiomyopathy, Congestive	FA GN	12373648
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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GeneTests: JUP

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Human Gene Mutation Database: JUP

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/557 PubMed articles for JUP gene (see all 557 ):

A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. (PubMed id 17924338)^{1, 3, 4} Asimaki A....McKenna W.J. (2007)
Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). (PubMed id 1889810)^{1, 2, 3} Arnemann J....Buxton R.S. (1991)
Genomic organization and amplification of the human plakoglobin gene (JUP). (PubMed id 11016852)^{1, 3, 4} Whittock N.V.... McGrath J.A. (2000)
Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). (PubMed id 10902626)^{1, 3, 4} McKoy G....McKenna W.J. (2000)
The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. (PubMed id 7604000)^{1, 2, 3} Aberle H....Lynch H.T. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)^{3, 4} Zhang Y.... White F.M. (2005)
Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy. (PubMed id 12373648)^{1, 7} Rampazzo A....Danieli G.A. (2002)
Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. (PubMed id 9139698)^{3, 4} Yamamoto M....Kufe D. (1997)
Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein. (PubMed id 2726765)^{3, 4} Franke W.W.... Cowin P. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3728	HGNC: 6207	AceView: JUP	Ensembl:ENSG00000173801	euGenes: HUgn3728
ECgene: JUP	H-InvDB: JUP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for JUP	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=JUP

Licensable Technologies for JUP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for JUP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JUP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JUP		Antibodies for JUP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for JUP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (JUP)
	Antibodies (JUP)
	Chimera RNAi (JUP)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for JUP (_-Catenin)

	Recombinant Proteins (gamma Catenin)
	Antibodies (gamma Catenin)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for JUP

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for JUP

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
JUP Gene at Home site.
Version 2.41.1
server5.xennexinc.com

JUP Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for JUP

Summaries
for JUP

Genomic Location
for JUP

Proteins
for JUP

Protein Domains/
Families
for JUP

Gene Function
for JUP

Pathways & Interactions
for JUP

Drugs & Compounds
for JUP

Transcripts
for JUP

Expression
for JUP

Orthologs
for JUP

Paralogs
for JUP

SNPs/Variants
for JUP

Disorders & Mutations
for JUP

Medical News
for JUP

Publications
for JUP

Search for JUP

Genome Databases showing JUP

Other Databases showing JUP

Specialized Databases showing JUP

Licensable Technologies
for JUP

Services
for JUP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JUP Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor JUP

Summariesfor JUP

Genomic Locationfor JUP

Proteinsfor JUP

Protein Domains/Familiesfor JUP

Gene Functionfor JUP

Pathways & Interactionsfor JUP

Drugs & Compoundsfor JUP

Transcriptsfor JUP

Expression for JUP

Orthologsfor JUP

Paralogsfor JUP

SNPs/Variantsfor JUP

Disorders & Mutationsfor JUP

Medical Newsfor JUP

Publicationsfor JUP

Search for JUP

Genome Databases showing JUP

Other Databases showing JUP

Specialized Databases showing JUP

Licensable Technologiesfor JUP

Servicesfor JUP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JUP

Summaries
for JUP

Genomic Location
for JUP

Proteins
for JUP

Protein Domains/
Families
for JUP

Gene Function
for JUP

Pathways & Interactions
for JUP

Drugs & Compounds
for JUP

Transcripts
for JUP

Expression
for JUP

Orthologs
for JUP

Paralogs
for JUP

SNPs/Variants
for JUP

Disorders & Mutations
for JUP

Medical News
for JUP

Publications
for JUP

Licensable Technologies
for JUP

Services
for JUP