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JUND Gene

protein-coding   GIFtS: 65
GCID: GC19M018391

Jun D Proto-Oncogene

  See JUND-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jun D Proto-Oncogene1 2
Activator Protein 11 2
JunD-FL Isoform1 2
Transcription Factor Jun-D1 2
AP-12

External Ids:    HGNC: 62061   Entrez Gene: 37272   Ensembl: ENSG000001305227   OMIM: 1651625   UniProtKB: P175353   

Export aliases for JUND gene to outside databases

Previous GC identifers: GC19M018884 GC19M018782 GC19M018235 GC19M018252 GC19M018253 GC19M018254 GC19M017954


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JUND Gene:
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1
transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and
apoptosis. Alternative translation initiation site usage results in the production of different isoforms
(PMID:12105216). (provided by RefSeq, Nov 2013)

GeneCards Summary for JUND Gene:
JUND (jun D proto-oncogene) is a protein-coding gene. Diseases associated with JUND include human t-cell leukemia virus type 1, and wermer syndrome. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
Function: Transcription factor binding AP-1 sites

Gene Wiki entry for JUND (JunD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the JUND gene promoter:
         CREB   Pax-3   C/EBPbeta   Sp1   deltaCREB   NRSF form 2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJUND promoter sequence
   Search Chromatin IP Primers for JUND

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JUND


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

JUND Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUND gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018391:  view genomic region     (about GC identifiers)

Start:
18,390,563 bp from pter      End:
18,392,432 bp from pter
Size:
1,870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: JUND_HUMAN, P17535 (See protein sequence)
Recommended Name: Transcription factor jun-D  
Size: 347 amino acids; 35174 Da
Subunit: Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional
activation
Sequence caution: Sequence=CAA40010.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for JUND:
3U86 (3D)    
Secondary accessions: Q53EK9

Explore the universe of human proteins at neXtProt for JUND: NX_P17535

Explore proteomics data for JUND at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JUND Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273897.1  NP_005345.3  

    ENSEMBL proteins: 
     ENSP00000475153   ENSP00000252818  

    JUND Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for JUND
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    Novus Biologicals JUND Protein
    Novus Biologicals JUND Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JUND

     
    Search eBioscience for Proteins for JUND 

     
    antibodies-online proteins for JUND (6 products) 

     
    antibodies-online peptides for JUND

    JUND Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of JUND
    R&D Systems Antibodies for JUND
    Cell Signaling Technology (CST) Antibodies for JUND 
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    Novus Biologicals JUND Antibodies
    Abcam antibodies for JUND
    Cloud-Clone Corp. Antibodies for JUND
    ThermoFisher Antibodies for JUND
    antibodies-online antibodies for JUND (105 products) 

    JUND Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JUND
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JUND
    Cloud-Clone Corp. CLIAs for JUND
    Search eBioscience for ELISAs for JUND 
    antibodies-online kits for JUND (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    4 InterPro protein domains:
     IPR002112 Leuzip_Jun
     IPR004827 bZIP
     IPR008917 TF_DNA-bd
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P17535

    ProtoNet protein and cluster: P17535

    3 Blocks protein domains:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with JUND           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JUND_HUMAN, P17535
    Function: Transcription factor binding AP-1 sites

         Genatlas biochemistry entry for JUND:
    jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17577209
    GO:0016922ligand-dependent nuclear receptor binding IEA--
         
    Find genes that share ontologies with JUND           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for JUND:
     Actin fiber cells  Increased circadian period len  Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jund):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  reproductive system  respiratory system 

    Find genes that share phenotypes with JUND           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for JUND

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for JUND (see all 2409):
    A2ML1,  A4GALT,  AAA1,  AAAS,  AATF,  ABCA1,  ABCA12,  ABCA9,  ABCB1,  ABCB6

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATGACGTCATCN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target JUND:
    hsa-mir-335-5p (MIRT017287), hsa-mir-186-5p (MIRT045282), hsa-mir-663a (MIRT005354)

    Block miRNA regulation of human, mouse, rat JUND using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JUND (see all 20):
    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidJUND 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for JUND
    Predesigned siRNA for gene silencing in human, mouse, rat JUND

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JUND

    Clone
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    OriGene clones in human, mouse for JUND (see all 6)
    OriGene ORF clones in mouse, rat for JUND
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JUND (NM_005354)
    Sino Biological Human cDNA Clone for JUND
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUND
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JUND

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for JUND
    Browse ESI BIO Cell Lines and PureStem Progenitors for JUND 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUND

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12104) for JUND 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JUND_HUMAN, P17535: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS1903194
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043234protein complex IEA--

    Find genes that share ontologies with JUND           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JUND About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    5Immune response IL 2 activation and signaling pathway
    Immune response IL 2 activation and signaling pathway0.41
    Immune response IL 3 activation and signaling pathway0.41


    Find genes that share SuperPaths with JUND           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for JUND (see all 10)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for JUND (see all 8)
        CRHR Pathway
    iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for JUND
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for JUND (see all 9)
        Immune response IL-6 signaling pathway
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways

    Selected BioSystems Pathways for JUND (see all 10)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    Oncostatin M Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Hypertrophy Model


    1 PharmGKB Pathway for JUND
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for JUND):
        MAPK signaling pathway
    Osteoclast differentiation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUND: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JUND

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JUND (P175351, 2, 3 ENSP000002528184) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSP011001, 3, ENSP000003062454EBI-2682803,EBI-852851 I2D: score=6 STRING: ENSP00000306245
    ATF7P175442, 3MINT-6699684 MINT-6699624 I2D: score=1 
    MDM2Q009871, 3, ENSP000004172814EBI-2682803,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    ACTR3P611581, 3EBI-2682803,EBI-351428 I2D: score=1 
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=3 STRING: ENSP00000267569
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    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002076osteoblast development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1903194
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007568aging IEA--

    Find genes that share ontologies with JUND           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JUND

    Selected Novoseek inferred chemical compound relationships for JUND gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxamflatin 75 2 8700540 (1), 10229197 (1)
    12-o-tetradecanoylphorbol 13-acetate 58.1 6 13679379 (2), 9178763 (1), 8426742 (1), 8631129 (1) (see all 5)
    rpa 2 56.3 2 15691381 (1), 15153434 (1)
    okadaic acid 49.8 11 9873060 (4), 1662987 (2), 9178763 (1), 7848922 (1) (see all 6)
    phorbol 46.8 3 10098722 (2), 7759510 (1)
    beta-naphthoflavone 46.3 1 7957257 (1)
    leucine 43.1 3 16829632 (1), 8423806 (1), 12183893 (1)
    tbhq 41 1 16007120 (1)
    anisomycin 40.3 2 9528756 (1)
    oligonucleotide 24.5 6 8617220 (1), 19211927 (1), 8761947 (1), 9297634 (1)



    Find genes that share compounds with JUND           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JUND gene (2 alternative transcripts): 
    NM_001286968.1  NM_005354.5  

    Unigene Cluster for JUND:

    Jun D proto-oncogene
    Hs.2780  [show with all ESTs]
    Unigene Representative Sequence: NM_005354
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600972 ENST00000252818(uc002nip.2)
    miRNA
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    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidJUND 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: JUND (NM_005354)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JUND
    Primer
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    OriGene qPCR primer pairs and template standards for JUND
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JUND
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      QuantiFast Probe-based Assays in human, mouse, rat JUND
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    eBioscience FlowRNA Probe Sets ( VA1-12104) for JUND 

    Additional mRNA sequence: 

    AB593186.1 AK223630.1 X51346.1 

    13 DOTS entries:

    DT.85100558  DT.100884526  DT.100884527  DT.121452631  DT.100044646  DT.91747520  DT.95253758  DT.97845437 
    DT.100044647  DT.100803673  DT.100884510  DT.95253766  DT.97811564 

    Selected AceView cDNA sequences (see all 343):

    AI123329 BM142511 AI351466 BM142338 BE676680 AI469360 C01090 BU737925 
    AI703140 BQ549566 BF726446 BF850165 CD677465 AI470387 BI011343 BF849495 
    BF591264 AI024896 BM711823 CD676385 BM127267 AI337326 AI150665 CK906159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    JUND expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCCCCGC
    JUND Expression
    About this image


    JUND expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Colon (Gastrointestinal Tract)
     
     Breast (Uncategorized)
    JUND Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JUND Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2780
        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUND: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Transcription Factors in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for JUND
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    QuantiTect SYBR Green Assays in human, mouse, rat JUND
    QuantiFast Probe-based Assays in human, mouse, rat JUND
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUND

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JUND gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jund1 , 5 Jun proto-oncogene related gene d5
    jun D proto-oncogene1
    80.45(n)1
    83.59(a)1
      8 (34.15 cM)5
    164781  NM_010592.51  NP_034722.11 
     706977395 
    lizard
    (Anolis carolinensis)
    Reptilia JUND6
    jun D proto-oncogene
    84(a)
    1 ↔ 1
    GL344469.1(3142-3489)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia jund1 jun D proto-oncogene 63.87(n)
    70.81(a)
      100126216  XM_002937933.2  XP_002937979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jund1 jun D proto-oncogene 69.95(n)
    67.05(a)
      564873  NM_001128342.1  NP_001121814.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    34(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUND (if available)
    TreeFam Gene Tree for JUND (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JUND gene
    JUN2  JUNB2  
    2 SIMAP similar genes for JUND using alignment to 2 protein entries:     JUND_HUMAN (see all proteins):
    JUN    JUNB

    Find genes that share paralogs with JUND           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JUND (see all 48)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878357541,2
    --18390078(+) AAAGCC/TTACAC 1 -- ds50010--------
    rs562242191,2
    C,F--18390157(+) CGACTG/CTTCTC 1 -- ds50012Minor allele frequency- C:0.03WA 120
    rs413884511,2
    C,F--18390242(-) CAGCCC/TAAAGC 1 -- ds50015Minor allele frequency- T:0.01NS 166
    rs414462501,2
    C,F--18390253(-) GGGCAC/TAGCCC 1 -- ds50017Minor allele frequency- T:0.09NS CSA NA 288
    rs757309921,2
    F--18390294(+) GGCAAG/AGGGGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs413496521,2
    C,F--18390440(-) AGGGAG/ACAGAG 1 -- ds50016Minor allele frequency- A:0.01NS CSA 192
    rs1926412071,2
    --18390550(+) GGAAGA/GAGGAG 1 -- ds50010--------
    rs152121,2
    C--18390664(-) TTTTTG/TTTCTG 1 -- ut312Minor allele frequency- T:0.08MN NA 186
    rs414950461,2
    C--18390701(-) TCCCCC/GCTTCG 1 -- ut316Minor allele frequency- G:0.00NS NA 192
    rs748815311,2
    C--18390863(+) CCAAAA/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for JUND (18390563 - 18392432 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for JUND:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv828472CNV Loss20364138
    esv29755CNV Loss19812545
    dgv3781n71CNV Loss21882294
    nsv911271CNV Loss21882294
    dgv3779n71CNV Loss21882294
    dgv3780n71CNV Loss21882294
    dgv3774n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JUND
    DNA2.0 Custom Variant and Variant Library Synthesis for JUND

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 165162    OMIM disorders: --

    3 diseases for JUND:    
    About MalaCards
    human t-cell leukemia virus type 1    wermer syndrome    kidney cancer

    2 diseases from the University of Copenhagen DISEASES database for JUND:
    Wermer syndrome     Adult T-cell leukemia

    Find genes that share disorders with JUND           About GenesLikeMe

    Selected Novoseek inferred disease relationships for JUND gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 64.4 1 11145887 (1)
    multiple endocrine neoplasia type 1 56.4 2 15126560 (1), 14559791 (1)
    tumors 30.9 14 11221882 (2), 9753632 (1), 8649827 (1), 10673028 (1) (see all 12)
    myeloid leukemia 21.1 3 8512587 (2), 1373742 (1)
    neoplastic transformation 20.8 1 10874008 (1)
    erythroleukemia 12.9 1 8619836 (1)
    lymphoma 11 2 15507668 (1), 12907453 (1)
    leukemia 5.22 3 12082101 (2), 8423806 (1)
    necrosis 0 1 9528756 (1)
    shock 0 1 14688620 (1)

    Genetic Association Database (GAD): JUND
    Human Genome Epidemiology (HuGE) Navigator: JUND (4 documents)

    Export disorders for JUND gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JUND gene, integrated from 10 sources (see all 323):
    (articles sorted by number of sources associating them with JUND)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of human jun-D. (PubMed id 1903194)1, 2, 3, 9 Berger I. and Shaul Y. (Oncogene 1991)
    2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)1, 2, 3 Nomura N.... Ishizaki R. (Nucleic Acids Res. 1990)
    3. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
    4. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. (PubMed id 9989505)1, 2 Agarwal S.K.... Burns A.L. (Cell 1999)
    5. JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. (PubMed id 16007120)1, 9 Tsuji Y. (Oncogene 2005)
    6. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PubMed id 18386285)1, 9 Mehraein-Ghomi F....Wilding G. (Prostate 2008)
    7. Translational regulation of the JunD messenger RNA. (PubMed id 12105216)1, 9 Short J.D. and Pfarr C.M. (J. Biol. Chem. 2002)
    8. Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. (PubMed id 12082101)1, 9 Li T....Lu L. (J. Biol. Chem. 2002)
    9. Differential binding of the Menin tumor suppressor protein to JunD isoforms. (PubMed id 11221882)1, 9 Yazgan O. and Pfarr C.M. (Cancer Res. 2001)
    10. Decreased transcription factor junD in brains of patients with Down syndrome. (PubMed id 9739985)1, 9 Labudova O....Lubec G. (Neurosci. Lett. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3727 HGNC: 6206 AceView: JUND Ensembl:ENSG00000130522 euGenes: HUgn3727
    ECgene: JUND Kegg: 3727 H-InvDB: JUND

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JUND Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUND Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JUND gene:
    Search GeneIP for patents involving JUND

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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