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Aliases & Descriptions for JUND
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| JunD-FL isoform 2 | | activator protein 1 2 | | jun D proto-oncogene 2 | | transcription factor jun-D 2 |
|
| | Search outside databases for aliases for JUND genePrevious GC identifers: GC19M018884 GC19M018782 GC19M018235 GC19M018252 GC19M018253 |
Summaries for JUND(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for JUND: The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage results in the production of different isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: JUND_HUMAN, P17535Function: Binds an AP-1 site and upon cotransfection stimulates the activity of a promoter that bears an AP-1 siteGene Wiki entry for JUND (JunD) |
Genomic Location for JUND
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the JUND gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.2JUND Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M018254:
(about GC identifiers)
Start:
|
18,251,570 bp from pter |
End:
|
18,253,432 bp from pter |
Size:
|
1,863 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for JUND
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: JUND_HUMAN, P17535 (See
protein sequence)Recommended Name: Transcription factor jun-D Size: 347 amino acids; 35174 Da
Subunit: Binds DNA as a dimer (By similarity)
Subcellular location: Nucleus
Sequence caution: Sequence=CAA40010.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q53EK9Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005345.3
ENSEMBL proteins: ENSP00000252818
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for JUND: Assays for JUND: | Protein
Domains/ Families for JUND(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P17535
ProtoNet protein and cluster: P17535 3 Blocks protein families: IPB002112 Jun transcription factor signature IPB005643 Jun-like transcription factor IPB011616 bZIP transcription factor
UniProtKB/Swiss-Prot: JUND_HUMAN, P17535Similarity: Belongs to the bZIP family. Jun subfamilySimilarity: Contains 1 bZIP domain | Gene Function for JUND
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005354
Applied Biosystems Silencer® siRNAs for JUND
Sigma-Aldrich siRNA for JUND  Sigma-Aldrich shRNA Panels and shRNA for JUND  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005354                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005354                                  untagged cDNA clone in CMV expression vector: NM_005354 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005354
UniProtKB/Swiss-Prot: JUND_HUMAN, P17535Function: Binds an AP-1 site and upon cotransfection stimulates the activity of a promoter that bears an AP-1 siteGenatlas biochemistry entry for JUND:jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN113 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Jund):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0003702 | RNA polymerase II transcription factor activity |
TAS | 1903194 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- | About this table | Pathways & Interactions for JUND
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for JUND (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for JUND 
5/62 Interacting proteins for JUND (ENSP000002528183 P175352) via UniProtKB, MINT, and/or STRING (see all 62
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002076 | osteoblast development |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 1903194 | | GO:0045669 | positive regulation of osteoblast differentiation |
IEA | -- | About this table
|
Drugs & Compounds for JUND(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for JUND |
Browse Tocris compounds for JUND 10/14 Novoseek chemical compound relationships for JUND gene (see all 14
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| oxamflatin |
76.17 |
2 |
8700540 (1), 10229197 (1) |
| rpa 2 |
59.31 |
2 |
15691381 (1), 15153434 (1) |
| 12-o-tetradecanoylphorbol 13-acetate |
58.65 |
6 |
13679379 (2), 9178763 (1), 8426742 (1), 8631129 (1) (see all 5) |
| okadaic acid |
50.60 |
11 |
9873060 (4), 1662987 (2), 9178763 (1), 7848922 (1) (see all 6) |
| phorbol |
47.38 |
3 |
10098722 (2), 7759510 (1) |
| leucine |
42.07 |
3 |
16829632 (1), 8423806 (1), 12183893 (1) |
| oligonucleotide |
22.17 |
5 |
8617220 (1), 8761947 (1), 9297634 (1) |
| pd 98,059 |
14.96 |
2 |
10762717 (1), 12082101 (1) |
| cyclic amp |
14.72 |
3 |
8700540 (1), 7791794 (1) |
| thymidine |
4.17 |
1 |
8648139 (1) |
About this table
|
Transcripts for JUND(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005354
Sigma-Aldrich siRNA for JUND  Sigma-Aldrich shRNA Panels and shRNA for JUND  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005354 REFSEQ mRNAs for JUND gene: NM_005354.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005354               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005354                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005354                                  untagged cDNA clone in CMV expression vector: NM_005354  Additional cDNA sequence: AK223630.1 X51346.1 12 DOTS entries: DT.85100558 DT.100884526 DT.100884527 DT.121452631 DT.91747520 DT.95253758 DT.100803673 DT.91717144 DT.95253766 DT.97811564 DT.97845437 DT.99996172 24/343 AceView cDNA sequences (see all 343
):BM142511 C01090 CK906159 AW304480 AI523919 BQ189321 BM711631 AA418676 AI351466 BM142338 BF939137 BF726446 BF849495 CD677465 AI703459 CB049681 AA580015 BF591264 BQ102308 BM855925 CB049917 AI220026 BI011343 BE676680
highest scoring ESTs for JUND:AA463309 AA994250 AI123329 AI142110 AI190302 AI198388 AI199043 AI206161 AI215085 AI215486 Unigene Cluster for JUND: Jun D proto-oncogene Hs.2780 [show with all ESTs]Unigene Representative Sequence: NM_005354
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000252818
|
Expression for JUND
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| JUND expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for JUND
1 / 2 / 3 9 probe-sets matching JUND gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACCCCCCCGC
SOURCE GeneReport for Unigene cluster: Hs.2780
Expression variation in blood from EXPOLDB for JUND |
Orthologs for JUND
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for JUND gene from 5/8 species (see all 8
)
About this table Species with no ortholog for JUND
ENSEMBL Gene Tree for JUND | Paralogs for JUND(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for JUND gene
- JUN2 JUNB2
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for JUND(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for JUND (up to first 250kb)
|
Disorders & Mutations for JUND
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 165162
10/19 Novoseek disease relationships for JUND gene (see all 19
)
About this table
Genetic Association Database: JUND Human Genome Epidemiology Navigator: JUND (2 documents)
|
Medical News for JUND(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for JUND (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/282 PubMed articles for JUND gene (see all 282
):- Structure and function of human jun-D. (PubMed id 1903194)1, 2, 3, 4 Berger I. and Shaul Y. (1991)
- Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)2, 3, 4 Nomura N.... Ishizaki R. (1990)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. (PubMed id 16007120)1, 3 Tsuji Y. (2005)
- JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PubMed id 18386285)1, 3 Mehraein-Ghomi F....Wilding G. (2008)
- Translational regulation of the JunD messenger RNA. (PubMed id 12105216)1, 3 Short J.D. and Pfarr C.M. (2002)
- Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. (PubMed id 12082101)1, 3 Li T....Lu L. (2002)
- Differential binding of the Menin tumor suppressor protein to JunD isoforms. (PubMed id 11221882)1, 3 Yazgan O. and Pfarr C.M. (2001)
- Decreased transcription factor junD in brains of patients with Down syndrome. (PubMed id 9739985)1, 3 Labudova O....Lubec G. (1998)
|
Search for JUND
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing JUND
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing JUND
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JUND(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for JUND(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for JUND:

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Incremental update: 13 Oct 2009
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