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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JUND Gene

protein-coding   GIFtS: 63
GCID: GC19M018391

jun D proto-oncogene

 Explore 44 diseases affiliated with
JUND via our new
 Human Malady Compendium 
Biological research products
for JUND
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Jun D Proto-Oncogene1 2
AP-11 2
Activator Protein 12
JunD-FL Isoform2
Transcription Factor Jun-D2

External Ids:    HGNC: 62061   Entrez Gene: 37272   Ensembl: ENSG000001305227   OMIM: 1651625   UniProtKB: P175353   

Export aliases for JUND gene to outside databases

Previous GC identifers: GC19M018884 GC19M018782 GC19M018235 GC19M018252 GC19M018253 GC19M018254 GC19M017954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JUND:
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1
transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis.
Alternate translation initiation site usage results in the production of different isoforms. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
Function: Transcription factor binding AP-1 sites

Gene Wiki entry for JUND (JunD)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JUND gene promoter:
         CREB   Pax-3   C/EBPbeta   Sp1   deltaCREB   NRSF form 2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJUND promoter sequence
   Search SABiosciences Chromatin IP Primers for JUND

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUND


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

JUND Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUND gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018391:  view genomic region     (about GC identifiers)

Start:
18,390,563 bp from pter      End:
18,392,432 bp from pter
Size:
1,870 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JUND_HUMAN, P17535 (See protein sequence)
Recommended Name: Transcription factor jun-D  
Size: 347 amino acids; 35174 Da
Subunit: Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional
activation
Subcellular location: Nucleus
Sequence caution: Sequence=CAA40010.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for JUND:
3U86 (3D)    
Secondary accessions: Q53EK9

Explore the universe of human proteins at neXtProt for JUND: NX_P17535

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17535

  • JUND Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005345.3  
    ENSEMBL proteins: 
     ENSP00000252818  

    Human Recombinant Protein Products: 
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    Novus Biologicals JUND Protein
    Novus Biologicals JUND Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for JUND

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS1903194
    GO:0005634nucleus IEA--
    GO:0043234protein complex IEA--


    JUND for ontologies           About GeneDecksing



    JUND Antibody Products: 
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    Uscn ELISAs and CLIAs for JUND


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    JUND for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004827 bZIP
     IPR008917 Euk_TF_DNA-bd
     IPR002112 Leuzip_Jun
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P17535

    ProtoNet protein and cluster: P17535

    3 Blocks protein families:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
    Function: Transcription factor binding AP-1 sites

         Genatlas biochemistry entry for JUND:
    jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1

    10/2460 SABiosciences Target genes for JUND (see all 2460):
    A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

    miRNA
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    hsa-mir-663 (MIRT005354)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUND
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate JUND (see all 20):
    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidJUND 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUND (see all 4)
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0016922ligand-dependent nuclear receptor binding IEA--


    JUND for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for JUND:
     Actin fiber cells  Increased circadian period len  Upregulation of Wnt/beta-caten 

    Animal Models:
         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jund):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  reproductive system  respiratory system 

    JUND for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/28 super-pathways (see all 28About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response_IL-2 activation and signaling pathway
    Immune response IL-2 activation and signaling pathway1.00
    Immune response_IL-3 activation and signaling pathway0.41
    Immune response_IL-2 activation and signaling pathway1.00
    Immune response IL-3 activation and signaling pathway0.41
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.15
    Immune response_Oncostatin M signaling via MAPK in human cells0.39
    3Immune response_IL-1 signaling pathway
    Immune response_IL-1 signaling pathway1.00
    Immune response IL-1 signaling pathway0.98
    4Signal transduction_JNK pathway
    Signal transduction_JNK pathway1.00
    Signal transduction JNK pathway0.98
    5Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways1.00
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/7 EMD Millipore Pathways for JUND (see all 7)
        Immune response CD16 signaling in NK cells
    Immune response IL-6 signaling pathway
    Signal transduction JNK pathway
    Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    5 R&D Systems Pathways for JUND
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    Th1 Differentiation
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JUND (see all 8)
        CRHR Pathway
    iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for JUND
        MAP Kinase Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for JUND (see all 9)
        Immune response IL-6 signaling pathway
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways

    5/8 BioSystems Pathways for JUND (see all 8
        MAPK signaling pathway
    Oncostatin M Signaling Pathway
    EGFR1 Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    TGF-beta Receptor Signaling Pathway

    1 PharmGKB Pathway for JUND
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for JUND):
        MAPK signaling pathway
    Osteoclast differentiation


    JUND for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JUND

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/78 Interacting proteins for JUND (P175351, 2, 3 ENSP000002528184) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RFWD2Q8NHY22, 3, ENSP000003566414MINT-19380 I2D: score=3 STRING: ENSP00000356641
    ATF7P175442, 3MINT-6699684 MINT-6699624 I2D: score=1 
    MDM2Q009871, 3, ENSP000004172814EBI-2682803,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    ACTR3P611581, 3EBI-2682803,EBI-351428 I2D: score=1 
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=3 STRING: ENSP00000267569
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002076osteoblast development IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1903194
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007568aging IEA--


    JUND for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    JUND for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JUND
    10/31 Novoseek chemical compound relationships for JUND gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxamflatin 75 2 8700540 (1), 10229197 (1)
    12-o-tetradecanoylphorbol 13-acetate 58.1 6 13679379 (2), 9178763 (1), 8426742 (1), 8631129 (1) (see all 5)
    rpa 2 56.3 2 15691381 (1), 15153434 (1)
    okadaic acid 49.8 11 9873060 (4), 1662987 (2), 9178763 (1), 7848922 (1) (see all 6)
    phorbol 46.8 3 10098722 (2), 7759510 (1)
    beta-naphthoflavone 46.3 1 7957257 (1)
    leucine 43.1 3 16829632 (1), 8423806 (1), 12183893 (1)
    tbhq 41 1 16007120 (1)
    anisomycin 40.3 2 9528756 (1)
    oligonucleotide 24.5 6 8617220 (1), 19211927 (1), 8761947 (1), 9297634 (1)

    Search CenterWatch for drugs/clinical trials and news about JUND 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JUND gene: 
    NM_005354.4  

    Unigene Cluster for JUND:

    Jun D proto-oncogene
    Hs.2780  [show with all ESTs]
    Unigene Representative Sequence: NM_005354
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000252818(uc002nip.2)

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    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUND
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUND

    Additional cDNA sequence: 

    AB593186.1 AK223630.1 X51346.1 

    13 DOTS entries:

    DT.85100558  DT.100884526  DT.100884527  DT.121452631  DT.100044646  DT.91747520  DT.95253758  DT.97845437 
    DT.100044647  DT.100803673  DT.100884510  DT.95253766  DT.97811564 

    24/343 AceView cDNA sequences (see all 343):

    BM711823 CD677465 BF849495 BM127267 AI351466 AI337326 AW304480 BQ189321 
    AI703459 BM855925 CB049917 AA809639 AI703140 BI011343 AI817460 AI470387 
    BM711631 AI150665 AA580015 AI024896 AI220026 BM142338 AI523919 BF939137 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JUND expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCCCCCGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See JUND Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JUND

    SOURCE GeneReport for Unigene cluster: Hs.2780
        SABiosciences Expression via Pathway-Focused PCR Arrays including JUND: 
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    In Situ
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for JUND

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for JUND gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jund1 , 5 Jun proto-oncogene related gene d1, 5 82.57(n)1
    86.32(a)1
      8 (34.15 cM)5
    164781  NM_010592.41  NP_034722.11 
     706977395 
    lizard
    (Anolis carolinensis)
    Reptilia JUND6
    --
    84(a)
    1 ↔ 1
    GL344469.1(3142-3489)
    zebrafish
    (Danio rerio)
    Actinopterygii jund1 jun D proto-oncogene 72.1(n)
    70.45(a)
      564873  NM_001128342.1  NP_001121814.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    31(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUND (if available)
    TreeFam Gene Tree for JUND (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JUND gene
    JUN2  JUNB2  
    2 SIMAP similar genes for JUND using alignment to 1 protein entry:     JUND_HUMAN:
    JUN    JUNB

    JUND for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 NCBI SNPs in JUND are shown (see all 93    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878357541,2
    --18390078(+) AAAGCC/TTACAC 1 -- ds50010--------
    rs562242191,2
    C,--18390157(+) CGACTG/CTTCTC 1 -- ds50012Minor allele frequency- C:0.03WA 120
    rs413884511,2
    C,--18390242(-) CAGCCC/TAAAGC 1 -- ds50015Minor allele frequency- T:0.01NS 166
    rs414462501,2
    C,F,--18390253(-) GGGCAC/TAGCCC 1 -- ds50017Minor allele frequency- T:0.09NS CSA NA 288
    rs757309921,2
    --18390294(+) GGCAAG/AGGGGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs413496521,2
    C,F--18390440(-) AGGGAG/ACAGAG 1 -- ds50016Minor allele frequency- A:0.01NS CSA 192
    rs1926412071,2
    --18390550(+) GGAAGA/GAGGAG 1 -- ds50010--------
    rs152121,2
    C--18390664(-) TTTTTG/TTTCTG 1 -- ut312Minor allele frequency- T:0.08MN NA 186
    rs414950461,2
    C--18390701(-) TCCCCC/GCTTCG 1 -- ut316Minor allele frequency- G:0.00NS NA 192
    rs748815311,2
    C,--18390863(+) CCAAAA/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for JUND (18390563 - 18392432 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for JUND
         1 CNV: 67489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    JUND for disorders           About GeneDecksing

    OMIM gene information: 165162    OMIM disorders: --

    20/44 diseases for JUND (see all 44):    About MalaCards
    splenic marginal zone lymphoma    human t-cell leukemia virus type 1    multiple endocrine neoplasia    b-cell lymphomas
    hairy cell leukemia    wermer syndrome    adult t-cell leukemia    t-cell leukemia
    rheumatoid arthritis    myeloid leukemia    familial breast cancer    neuroendocrine tumor
    squamous cell carcinoma    leukemia    multiple myeloma    hepatocellular carcinoma
    breast cancer    down syndrome    ovarian cancer    arthritis

    2 diseases from the University of Copenhagen DISEASES database for JUND:
    Wermer syndrome     Adult T-cell leukemia

    10/19 Novoseek disease relationships for JUND gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 64.4 1 11145887 (1)
    multiple endocrine neoplasia type 1 56.4 2 15126560 (1), 14559791 (1)
    tumors 30.9 14 11221882 (2), 9753632 (1), 8649827 (1), 10673028 (1) (see all 12)
    myeloid leukemia 21.1 3 8512587 (2), 1373742 (1)
    neoplastic transformation 20.8 1 10874008 (1)
    erythroleukemia 12.9 1 8619836 (1)
    lymphoma 11 2 15507668 (1), 12907453 (1)
    leukemia 5.22 3 12082101 (2), 8423806 (1)
    necrosis 0 1 9528756 (1)
    shock 0 1 14688620 (1)

    Genetic Association Database (GAD): JUND
    Human Genome Epidemiology (HuGE) Navigator: JUND (4 documents)

    Export disorders for JUND gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JUND gene, integrated from 9 sources (see all 315):
    (articles sorted by number of sources associating them with JUND)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of human jun-D. (PubMed id 1903194)1, 2, 3, 9 Berger I. and Shaul Y. (1991)
    2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)1, 2, 3 Nomura N.... Ishizaki R. (1990)
    3. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. (PubMed id 9989505)1, 2 Agarwal S.K....Burns A.L. (1999)
    4. JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. (PubMed id 16007120)1, 9 Tsuji Y. (2005)
    5. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PubMed id 18386285)1, 9 Mehraein-Ghomi F....Wilding G. (2008)
    6. Translational regulation of the JunD messenger RNA. (PubMed id 12105216)1, 9 Short J.D. and Pfarr C.M. (2002)
    7. Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. (PubMed id 12082101)1, 9 Li T....Lu L. (2002)
    8. Differential binding of the Menin tumor suppressor protein to JunD isoforms. (PubMed id 11221882)1, 9 Yazgan O. and Pfarr C.M. (2001)
    9. Decreased transcription factor junD in brains of patients with Down syndrome. (PubMed id 9739985)1, 9 Labudova O....Lubec G. (1998)
    10. Differential phosphorylation of c-Jun and JunD in response to the epidermal growth factor is determined by the structure of MAPK targeting sequences. (PubMed id 14676207)1, 9 Vinciguerra M....Musti A.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3727 HGNC: 6206 AceView: JUND Ensembl:ENSG00000130522 euGenes: HUgn3727
    ECgene: JUND Kegg: 3727 H-InvDB: JUND

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JUND Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUND Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JUND gene:
    Search GeneIP for patents involving JUND

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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