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Aliases for JUND Gene

Aliases for JUND Gene

  • Jun D Proto-Oncogene 2 3
  • Transcription Factor Jun-D 2 3
  • Activator Protein 1 2 3
  • JunD-FL Isoform 2 3
  • AP-1 3

External Ids for JUND Gene

Summaries for JUND Gene

Entrez Gene Summary for JUND Gene

  • The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

GeneCards Summary for JUND Gene

JUND (Jun D Proto-Oncogene) is a Protein Coding gene. Diseases associated with JUND include human t-cell leukemia virus type 1 and breast cancer. Among its related pathways are MAPK signaling pathway and Akt Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is JUNB.

UniProtKB/Swiss-Prot for JUND Gene

  • Transcription factor binding AP-1 sites.

Gene Wiki entry for JUND Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUND Gene

Genomics for JUND Gene

Genomic Location for JUND Gene

Start:
18,279,694 bp from pter
End:
18,281,656 bp from pter
Size:
1,963 bases
Orientation:
Minus strand

Genomic View for JUND Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JUND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUND Gene

Regulatory Elements for JUND Gene

Proteins for JUND Gene

  • Protein details for JUND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17535-JUND_HUMAN
    Recommended name:
    Transcription factor jun-D
    Protein Accession:
    P17535
    Secondary Accessions:
    • Q53EK9

    Protein attributes for JUND Gene

    Size:
    347 amino acids
    Molecular mass:
    35174 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.
    SequenceCaution:
    • Sequence=CAA40010.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JUND Gene

neXtProt entry for JUND Gene

Proteomics data for JUND Gene at MOPED

Post-translational modifications for JUND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUND Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JUND Gene

Domains for JUND Gene

Gene Families for JUND Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Suggested Antigen Peptide Sequences for JUND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17535

UniProtKB/Swiss-Prot:

JUND_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • P17535
Family:
  • Belongs to the bZIP family. Jun subfamily.:
    • P17535
genes like me logo Genes that share domains with JUND: view

Function for JUND Gene

Molecular function for JUND Gene

GENATLAS Biochemistry: jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1
UniProtKB/Swiss-Prot Function: Transcription factor binding AP-1 sites.

Gene Ontology (GO) - Molecular Function for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
genes like me logo Genes that share ontologies with JUND: view
genes like me logo Genes that share phenotypes with JUND: view

miRNA for JUND Gene

miRTarBase miRNAs that target JUND

Transcription Factor Targeting for JUND Gene

Selected GeneGlobe predicted Target genes for JUND
Targeting motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
  • Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562

No data available for Enzyme Numbers (IUBMB) and Animal Models for JUND Gene

Localization for JUND Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUND Gene COMPARTMENTS Subcellular localization image for JUND gene
Compartment Confidence
nucleus 5
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 1903194
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IBA --
genes like me logo Genes that share ontologies with JUND: view

Pathways for JUND Gene

genes like me logo Genes that share pathways with JUND: view

Gene Ontology (GO) - Biological Process for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0002076 osteoblast development IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1903194
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with JUND: view

Compounds for JUND Gene

(31) Novoseek inferred chemical compound relationships for JUND Gene

Compound -log(P) Hits PubMed IDs
oxamflatin 75 2
12-o-tetradecanoylphorbol 13-acetate 58.1 6
rpa 2 56.3 2
okadaic acid 49.8 10
phorbol 46.8 3
genes like me logo Genes that share compounds with JUND: view

Transcripts for JUND Gene

mRNA/cDNA for JUND Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(343) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUND Gene

Jun D proto-oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JUND Gene

No ASD Table

Relevant External Links for JUND Gene

GeneLoc Exon Structure for
JUND
ECgene alternative splicing isoforms for
JUND

Expression for JUND Gene

mRNA expression in normal human tissues for JUND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JUND Gene

SOURCE GeneReport for Unigene cluster for JUND Gene Hs.2780

genes like me logo Genes that share expressions with JUND: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JUND Gene

Orthologs for JUND Gene

This gene was present in the common ancestor of animals.

Orthologs for JUND Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia JUND 35
  • 91.3 (n)
  • 93.62 (a)
dog
(Canis familiaris)
Mammalia JUND 35
  • 90.63 (n)
  • 92.17 (a)
JUND 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jund 35
  • 80.45 (n)
  • 83.59 (a)
Jund 16
Jund 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JUND 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JUND 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jund 35
  • 80.65 (n)
  • 83.59 (a)
lizard
(Anolis carolinensis)
Reptilia JUND 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jund 35
  • 63.87 (n)
  • 70.81 (a)
zebrafish
(Danio rerio)
Actinopterygii jund 35
  • 69.95 (n)
  • 67.05 (a)
jund 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Jra 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for JUND:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUND Gene

ENSEMBL:
Gene Tree for JUND (if available)
TreeFam:
Gene Tree for JUND (if available)

Paralogs for JUND Gene

Paralogs for JUND Gene

Selected SIMAP similar genes for JUND Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with JUND: view

Variants for JUND Gene

Sequence variations from dbSNP and Humsavar for JUND Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_055247 -

Structural Variations from Database of Genomic Variants (DGV) for JUND Gene

Variant ID Type Subtype PubMed ID
dgv3774n71 CNV Loss 21882294
dgv3779n71 CNV Loss 21882294
dgv3780n71 CNV Loss 21882294
nsv911271 CNV Loss 21882294
nsv828472 CNV Loss 20364138
dgv3781n71 CNV Loss 21882294
esv29755 CNV Loss 19812545

Relevant External Links for JUND Gene

HapMap Linkage Disequilibrium report
JUND

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene

Disorders for JUND Gene

(2) University of Copenhagen DISEASES for JUND Gene

(19) Novoseek inferred disease relationships for JUND Gene

Disease -log(P) Hits PubMed IDs
leukemia t-cell 64.4 1
multiple endocrine neoplasia type 1 56.4 2
tumors 30.9 13
myeloid leukemia 21.1 3
neoplastic transformation 20.8 1

Relevant External Links for JUND

Genetic Association Database (GAD)
JUND
Human Genome Epidemiology (HuGE) Navigator
JUND
genes like me logo Genes that share disorders with JUND: view

No data available for UniProtKB/Swiss-Prot for JUND Gene

Publications for JUND Gene

  1. Structure and function of human jun-D. (PMID: 1903194) Berger I. … Shaul Y. (Oncogene 1991) 2 3 4 23
  2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PMID: 2112242) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1990) 2 3 4
  3. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PMID: 18386285) Mehraein-Ghomi F. … Wilding G. (Prostate 2008) 3 23
  4. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A. … Uhal B.D. (FASEB J. 2009) 3 23
  5. Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation. (PMID: 12226747) Gallo A. … Musti A.M. (Oncogene 2002) 3 23

Products for JUND Gene

Sources for JUND Gene

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