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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JUND Gene

protein-coding   GIFtS: 64
GCID: GC19M018391

Jun D Proto-Oncogene

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Jun D Proto-Oncogene1 2
Activator Protein 11 2
JunD-FL Isoform1 2
Transcription Factor Jun-D1 2
AP-12

External Ids:    HGNC: 62061   Entrez Gene: 37272   Ensembl: ENSG000001305227   OMIM: 1651625   UniProtKB: P175353   

Export aliases for JUND gene to outside databases

Previous GC identifers: GC19M018884 GC19M018782 GC19M018235 GC19M018252 GC19M018253 GC19M018254 GC19M017954


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JUND Gene:
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1
transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis.
Alternate translation initiation site usage results in the production of different isoforms. (provided by RefSeq,
Jul 2008)

GeneCards Summary for JUND Gene: 
JUND (jun D proto-oncogene) is a protein-coding gene. Diseases associated with JUND include human t-cell leukemia virus type 1, and splenic marginal zone lymphoma, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and MAPK signaling pathway. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
Function: Transcription factor binding AP-1 sites

Gene Wiki entry for JUND (JunD) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JUND gene promoter:
         CREB   Pax-3   C/EBPbeta   Sp1   deltaCREB   NRSF form 2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJUND promoter sequence
   Search SABiosciences Chromatin IP Primers for JUND

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUND


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

JUND Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUND gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M018391:  view genomic region     (about GC identifiers)

Start:
18,390,563 bp from pter      End:
18,392,432 bp from pter
Size:
1,870 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JUND_HUMAN, P17535 (See protein sequence)
Recommended Name: Transcription factor jun-D  
Size: 347 amino acids; 35174 Da
Subunit: Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional
activation
Subcellular location: Nucleus
Sequence caution: Sequence=CAA40010.1; Type=Frameshift; Positions=Several;
1 PDB 3D structure from and Proteopedia for JUND:
3U86 (3D)    
Secondary accessions: Q53EK9

Explore the universe of human proteins at neXtProt for JUND: NX_P17535

Explore proteomics data for JUND at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17535

  • JUND Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JUND Protein Expression
    REFSEQ proteins: NP_005345.3  
    ENSEMBL proteins: 
     ENSP00000475153   ENSP00000252818  

    Human Recombinant Protein Products for JUND: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals JUND Protein
    Novus Biologicals JUND Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JUND 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS1903194
    GO:0005634nucleus IEA--
    GO:0043234protein complex IEA--

    JUND for ontologies           About GeneDecksing



    JUND Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of JUND
    R&D Systems Antibodies for JUND
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    Abcam antibodies for JUND
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    LSBio Antibodies in human, mouse, rat for JUND 

    Assay Products for JUND: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JUND 
    Cloud-Clone Corp. CLIAs for JUND


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    4 InterPro protein domains:
     IPR002112 Leuzip_Jun
     IPR004827 bZIP
     IPR008917 Euk_TF_DNA-bd
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P17535

    ProtoNet protein and cluster: P17535

    3 Blocks protein domains:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUND_HUMAN, P17535
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    JUND for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JUND_HUMAN, P17535
    Function: Transcription factor binding AP-1 sites

         Genatlas biochemistry entry for JUND:
    jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17577209
    GO:0016922ligand-dependent nuclear receptor binding IEA--
         
    JUND for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for JUND:
     Actin fiber cells  Increased circadian period len  Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jund):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  muscle  reproductive system  respiratory system 

    JUND for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for JUND 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JUND

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JUND 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JUND 

    10/2425 SABiosciences Target genes for JUND (see all 2425):
    A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target JUND:
    hsa-mir-663 (MIRT005354)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUND
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate JUND (see all 20):
    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidJUND 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for JUND
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    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for JUND
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    GenScript: all cDNA clones in your preferred vector: JUND (NM_005354)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUND
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JUND
    Sirion Biotech Customized lentivirus for stable overexpression of JUND 
                         Customized lentivirus expression plasmids for stable overexpression of JUND 

    Cell Line
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    Search LifeMap BioReagents cell lines for JUND
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUND


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for JUND About   (see all 29)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    IL-17 Signaling0.48
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    4Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41
    iNOS Signaling0.34
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for JUND (see all 7)
        Immune response CD16 signaling in NK cells
    Immune response IL-6 signaling pathway
    Signal transduction JNK pathway
    Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    5/9 R&D Systems Pathways for JUND (see all 9)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JUND (see all 8)
        CRHR Pathway
    iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling

    1 Cell Signaling Technology (CST) Pathway for JUND
        MAP Kinase Signaling

    5/9 GeneGo (Thomson Reuters) Pathways for JUND (see all 9)
        Immune response IL-6 signaling pathway
    Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways

    5/8 BioSystems Pathways for JUND (see all 8)
        MAPK signaling pathway
    EGFR1 Signaling Pathway
    Oncostatin M Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    AhR pathway

    1 PharmGKB Pathway for JUND
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for JUND):
        MAPK signaling pathway
    Osteoclast differentiation


    JUND for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JUND

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for JUND (P175351, 2, 3 ENSP000002528184) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RFWD2Q8NHY22, 3, ENSP000003566414MINT-19380 I2D: score=3 STRING: ENSP00000356641
    ATF7P175442, 3MINT-6699684 MINT-6699624 I2D: score=1 
    MDM2Q009871, 3, ENSP000004172814EBI-2682803,EBI-389668 I2D: score=1 STRING: ENSP00000417281
    ACTR3P611581, 3EBI-2682803,EBI-351428 I2D: score=1 
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=3 STRING: ENSP00000267569
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002076osteoblast development IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1903194
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007568aging IEA--

    JUND for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    JUND for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JUND

    10/31 Novoseek inferred chemical compound relationships for JUND gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oxamflatin 75 2 8700540 (1), 10229197 (1)
    12-o-tetradecanoylphorbol 13-acetate 58.1 6 13679379 (2), 9178763 (1), 8426742 (1), 8631129 (1) (see all 5)
    rpa 2 56.3 2 15691381 (1), 15153434 (1)
    okadaic acid 49.8 11 9873060 (4), 1662987 (2), 9178763 (1), 7848922 (1) (see all 6)
    phorbol 46.8 3 10098722 (2), 7759510 (1)
    beta-naphthoflavone 46.3 1 7957257 (1)
    leucine 43.1 3 16829632 (1), 8423806 (1), 12183893 (1)
    tbhq 41 1 16007120 (1)
    anisomycin 40.3 2 9528756 (1)
    oligonucleotide 24.5 6 8617220 (1), 19211927 (1), 8761947 (1), 9297634 (1)

    Search CenterWatch for drugs/clinical trials and news about JUND

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JUND gene: 
    NM_005354.4  

    Unigene Cluster for JUND:

    Jun D proto-oncogene
    Hs.2780  [show with all ESTs]
    Unigene Representative Sequence: NM_005354
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600972 ENST00000252818(uc002nip.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate JUND (see all 20):
    hsa-miR-485-5p hsa-miR-520d-5p hsa-miR-3655 hsa-miR-1908 hsa-miR-570 hsa-miR-4267 hsa-miR-375 hsa-miR-3121-3p
    SwitchGear 3'UTR luciferase reporter plasmidJUND 3' UTR sequence
    Inhib. RNA
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JUND
    Sirion Biotech Customized lentivirus for stable overexpression of JUND 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUND
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUND

    Additional mRNA sequence: 

    AB593186.1 AK223630.1 X51346.1 

    13 DOTS entries:

    DT.85100558  DT.100884526  DT.100884527  DT.121452631  DT.100044646  DT.91747520  DT.95253758  DT.97845437 
    DT.100044647  DT.100803673  DT.100884510  DT.95253766  DT.97811564 

    24/343 AceView cDNA sequences (see all 343):

    BF939137 AI817460 BM855925 BQ189321 BM711823 AI220026 AA809639 AA418676 
    AI703140 AI470387 AA029187 BQ549566 BE676680 BM711631 BF726446 BF850165 
    BM695088 BI962653 AI703459 BM142511 BQ102308 AI150665 BU737925 AI469360 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JUND expression in normal human tissues (normalized intensities)      JUND embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCCCCGC
    JUND Expression
    About this image


    JUND expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 5 entries
             Double Negative 2 Thymocytes Thymus
             neutrophils   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Breast (NULL)
             breast stroma   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See JUND Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JUND

    SOURCE GeneReport for Unigene cluster: Hs.2780
        SABiosciences Expression via Pathway-Focused PCR Arrays including JUND: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Transcription Factors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUND
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUND

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for JUND gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jund1 , 5 Jun proto-oncogene related gene d1, 5 82.57(n)1
    86.32(a)1
      8 (34.15 cM)5
    164781  NM_010592.41  NP_034722.11 
     706977395 
    lizard
    (Anolis carolinensis)
    Reptilia JUND6
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL344469.1(3142-3489)
    zebrafish
    (Danio rerio)
    Actinopterygii jund1 jun D proto-oncogene 72.1(n)
    70.45(a)
      564873  NM_001128342.1  NP_001121814.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    29(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUND (if available)
    TreeFam Gene Tree for JUND (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JUND gene
    JUN2  JUNB2  
    2 SIMAP similar genes for JUND using alignment to 1 protein entry:     JUND_HUMAN:
    JUN    JUNB

    JUND for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/48 SNPs in JUND are shown (see all 48)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0552474
    ----see VAR_0552472 G V mis40--------
    rs1878357541,2
    --18390078(+) AAAGCC/TTACAC 1 -- ds50010--------
    rs562242191,2
    C,F--18390157(+) CGACTG/CTTCTC 1 -- ds50012Minor allele frequency- C:0.03WA 120
    rs413884511,2
    C,F--18390242(-) CAGCCC/TAAAGC 1 -- ds50015Minor allele frequency- T:0.01NS 166
    rs414462501,2
    C,F--18390253(-) GGGCAC/TAGCCC 1 -- ds50017Minor allele frequency- T:0.09NS CSA NA 288
    rs757309921,2
    F--18390294(+) GGCAAG/AGGGGC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs413496521,2
    C,F--18390440(-) AGGGAG/ACAGAG 1 -- ds50016Minor allele frequency- A:0.01NS CSA 192
    rs1926412071,2
    --18390550(+) GGAAGA/GAGGAG 1 -- ds50010--------
    rs152121,2
    C--18390664(-) TTTTTG/TTTCTG 1 -- ut312Minor allele frequency- T:0.08MN NA 186
    rs414950461,2
    C--18390701(-) TCCCCC/GCTTCG 1 -- ut316Minor allele frequency- G:0.00NS NA 192

    HapMap Linkage Disequilibrium report for JUND (18390563 - 18392432 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for JUND:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv828472CNV Loss20364138
    esv29755CNV Loss19812545
    dgv3781n71CNV Loss21882294
    nsv911271CNV Loss21882294
    dgv3779n71CNV Loss21882294
    dgv3780n71CNV Loss21882294
    dgv3774n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for JUND

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165162    OMIM disorders: --

    20/42 diseases for JUND (see all 42):    About MalaCards
    human t-cell leukemia virus type 1    splenic marginal zone lymphoma    wermer syndrome    kidney cancer
    hairy cell leukemia    multiple endocrine neoplasia    t cell deficiency    familial breast cancer
    t-cell leukemia    adult t-cell leukemia    neuroendocrine tumor    oral cancer
    fibrosarcoma    glomerulonephritis    down syndrome    osteoarthritis
    multiple myeloma    hepatocellular carcinoma    psoriasis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for JUND:
    Wermer syndrome     Adult T-cell leukemia

    JUND for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for JUND gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 64.4 1 11145887 (1)
    multiple endocrine neoplasia type 1 56.4 2 15126560 (1), 14559791 (1)
    tumors 30.9 14 11221882 (2), 9753632 (1), 8649827 (1), 10673028 (1) (see all 12)
    myeloid leukemia 21.1 3 8512587 (2), 1373742 (1)
    neoplastic transformation 20.8 1 10874008 (1)
    erythroleukemia 12.9 1 8619836 (1)
    lymphoma 11 2 15507668 (1), 12907453 (1)
    leukemia 5.22 3 12082101 (2), 8423806 (1)
    necrosis 0 1 9528756 (1)
    shock 0 1 14688620 (1)

    Genetic Association Database (GAD): JUND
    Human Genome Epidemiology (HuGE) Navigator: JUND (4 documents)

    Export disorders for JUND gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JUND gene, integrated from 9 sources (see all 320):
    (articles sorted by number of sources associating them with JUND)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and function of human jun-D. (PubMed id 1903194)1, 2, 3, 9 Berger I. and Shaul Y. (1991)
    2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)1, 2, 3 Nomura N.... Ishizaki R. (1990)
    3. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (2007)
    4. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. (PubMed id 9989505)1, 2 Agarwal S.K....Burns A.L. (1999)
    5. JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress. (PubMed id 16007120)1, 9 Tsuji Y. (2005)
    6. JunD mediates androgen-induced oxidative stress in androgen dependent LNCaP human prostate cancer cells. (PubMed id 18386285)1, 9 Mehraein-Ghomi F....Wilding G. (2008)
    7. Translational regulation of the JunD messenger RNA. (PubMed id 12105216)1, 9 Short J.D. and Pfarr C.M. (2002)
    8. Ultraviolet-induced junD activation and apoptosis in myeloblastic leukemia ML-1 cells. (PubMed id 12082101)1, 9 Li T....Lu L. (2002)
    9. Differential binding of the Menin tumor suppressor protein to JunD isoforms. (PubMed id 11221882)1, 9 Yazgan O. and Pfarr C.M. (2001)
    10. Decreased transcription factor junD in brains of patients with Down syndrome. (PubMed id 9739985)1, 9 Labudova O....Lubec G. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3727 HGNC: 6206 AceView: JUND Ensembl:ENSG00000130522 euGenes: HUgn3727
    ECgene: JUND Kegg: 3727 H-InvDB: JUND

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JUND Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUND Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/tnfrsf1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JUND gene:
    Search GeneIP for patents involving JUND

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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