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Aliases for JUND Gene

Aliases for JUND Gene

  • JunD Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • Transcription Factor Jun-D 2 3
  • Activator Protein 1 2 3
  • JunD-FL Isoform 2 3
  • Jun D Proto-Oncogene 3
  • AP-1 3

External Ids for JUND Gene

Previous GeneCards Identifiers for JUND Gene

  • GC19M018884
  • GC19M018782
  • GC19M018235
  • GC19M018252
  • GC19M018253
  • GC19M018254
  • GC19M018391
  • GC19M017954

Summaries for JUND Gene

Entrez Gene Summary for JUND Gene

  • The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

GeneCards Summary for JUND Gene

JUND (JunD Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUND include T-Cell Leukemia and Adult T-Cell Leukemia. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is JUN.

UniProtKB/Swiss-Prot for JUND Gene

  • Transcription factor binding AP-1 sites.

Gene Wiki entry for JUND Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUND Gene

Genomics for JUND Gene

Regulatory Elements for JUND Gene

Enhancers for JUND Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018300 1.6 FANTOM5 Ensembl ENCODE 18.2 -22.9 -22850 8.2 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 ENSG00000268030 UPF1 COLGALT1 JUND LSM4 ANO8 PGPEP1 IL12RB1 ARRDC2 SSBP4
GH19F018289 1 FANTOM5 ENCODE 12.8 -10.6 -10581 6.1 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF548 SP3 TBX21 MEF2D ENSG00000268030 UPF1 ENSG00000268938 MVB12A COLGALT1 KIAA1683 JUND ELL ENSG00000268199 ENSG00000269191
GH19F018492 1.3 FANTOM5 Ensembl ENCODE 7.5 -219.7 -219745 18.8 MLX ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 NFYC ELL SSBP4 FKBP8 UBA52 CRTC1 KXD1 C19orf60 ARRDC2 JUND IL12RB1
GH19F018472 1.2 FANTOM5 Ensembl ENCODE 6.9 -199.7 -199733 16.8 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC KXD1 IFI30 ENSG00000268030 SSBP4 ELL ENSG00000268938 UBA52 UPF1 CRTC1 C19orf60
GH19F018512 1 FANTOM5 ENCODE 5.7 -236.2 -236155 10.5 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ELL SSBP4 FKBP8 ENSG00000268030 LRRC25 PGPEP1 IL12RB1 JUND KXD1 UPF1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around JUND on UCSC Golden Path with GeneCards custom track

Promoters for JUND Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418286 856 3601 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2

Genomic Location for JUND Gene

Chromosome:
19
Start:
18,279,694 bp from pter
End:
18,281,656 bp from pter
Size:
1,963 bases
Orientation:
Minus strand

Genomic View for JUND Gene

Genes around JUND on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUND Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUND Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUND Gene

Proteins for JUND Gene

  • Protein details for JUND Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17535-JUND_HUMAN
    Recommended name:
    Transcription factor jun-D
    Protein Accession:
    P17535
    Secondary Accessions:
    • Q53EK9

    Protein attributes for JUND Gene

    Size:
    347 amino acids
    Molecular mass:
    35174 Da
    Quaternary structure:
    • Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.
    SequenceCaution:
    • Sequence=CAA40010.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JUND Gene

neXtProt entry for JUND Gene

Post-translational modifications for JUND Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUND Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JUND Gene

Domains & Families for JUND Gene

Suggested Antigen Peptide Sequences for JUND Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17535

UniProtKB/Swiss-Prot:

JUND_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Jun subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUND: view

Function for JUND Gene

Molecular function for JUND Gene

GENATLAS Biochemistry:
jun protooncogene homolog D,ligand induced,immediate (primary) early response gene,inhibited by MEN1
UniProtKB/Swiss-Prot Function:
Transcription factor binding AP-1 sites.

Gene Ontology (GO) - Molecular Function for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with JUND: view
genes like me logo Genes that share phenotypes with JUND: view

Animal Models for JUND Gene

MGI Knock Outs for JUND:

Animal Model Products

Transcription Factor Targets for JUND Gene

Selected GeneGlobe predicted Target genes for JUND
Targeted motifs for JUND Gene
HOMER Transcription Factor Regulatory Elements motif JUND
  • Consensus sequence: ATGACGTCATCN Submotif: canonical Cell Type: K562

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUND Gene

Localization for JUND Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUND Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUND Gene COMPARTMENTS Subcellular localization image for JUND gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin TAS 1903194
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IEA,IDA --
GO:0005667 transcription factor complex IBA --
GO:0032993 protein-DNA complex IEA --
genes like me logo Genes that share ontologies with JUND: view

Pathways & Interactions for JUND Gene

genes like me logo Genes that share pathways with JUND: view

SIGNOR curated interactions for JUND Gene

Is activated by:

Gene Ontology (GO) - Biological Process for JUND Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0002076 osteoblast development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,TAS 1903194
genes like me logo Genes that share ontologies with JUND: view

Drugs & Compounds for JUND Gene

(20) Drugs for JUND Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(11) Additional Compounds for JUND Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUND: view

Transcripts for JUND Gene

mRNA/cDNA for JUND Gene

Unigene Clusters for JUND Gene

Jun D proto-oncogene:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JUND Gene

No ASD Table

Relevant External Links for JUND Gene

GeneLoc Exon Structure for
JUND
ECgene alternative splicing isoforms for
JUND

Expression for JUND Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JUND Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUND Gene

This gene is overexpressed in Blymphocyte (17.6), Placenta (10.2), Peripheral blood mononuclear cells (6.6), and Monocytes (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JUND Gene



Protein tissue co-expression partners for JUND Gene

NURSA nuclear receptor signaling pathways regulating expression of JUND Gene:

JUND

SOURCE GeneReport for Unigene cluster for JUND Gene:

Hs.2780
genes like me logo Genes that share expression patterns with JUND: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JUND Gene

Orthologs for JUND Gene

This gene was present in the common ancestor of animals.

Orthologs for JUND Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia JUND 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JUND 34
  • 91.3 (n)
dog
(Canis familiaris)
Mammalia JUND 35 34
  • 90.63 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jund 34
  • 80.65 (n)
mouse
(Mus musculus)
Mammalia Jund 34 16 35
  • 80.45 (n)
oppossum
(Monodelphis domestica)
Mammalia JUND 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JUND 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jund 34
  • 63.87 (n)
zebrafish
(Danio rerio)
Actinopterygii jund 34 35
  • 69.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jra 35
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
OneToMany
Species where no ortholog for JUND was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUND Gene

ENSEMBL:
Gene Tree for JUND (if available)
TreeFam:
Gene Tree for JUND (if available)

Paralogs for JUND Gene

Paralogs for JUND Gene

(2) SIMAP similar genes for JUND Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with JUND: view

Variants for JUND Gene

Sequence variations from dbSNP and Humsavar for JUND Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401251 -- 18,281,470(+) CCGTA(A/G)AAGGG upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1126915 -- 18,280,269(-) GAGGG(C/T)GCCCA upstream-variant-2KB, utr-variant-3-prime
rs113070695 -- 18,283,320(+) CAGGA(A/G)GCTGA upstream-variant-2KB
rs11550220 -- 18,280,368(+) AGTCC(C/G)GGGCG upstream-variant-2KB, utr-variant-3-prime
rs11550221 -- 18,280,339(+) GGGGG(A/G)TCCCC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JUND Gene

Variant ID Type Subtype PubMed ID
dgv6293n54 CNV gain+loss 21841781
dgv6294n54 CNV gain 21841781
dgv6295n54 CNV gain 21841781
dgv6296n54 CNV loss 21841781
esv29755 CNV loss 19812545
nsv1126517 CNV deletion 24896259
nsv578744 CNV gain 21841781
nsv828472 CNV loss 20364138
nsv952420 CNV deletion 24416366

Variation tolerance for JUND Gene

Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JUND Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUND

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUND Gene

Disorders for JUND Gene

MalaCards: The human disease database

(3) MalaCards diseases for JUND Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
multiple endocrine neoplasia 1
  • multiple endocrine neoplasia, type i
- elite association - COSMIC cancer census association via MalaCards
Search JUND in MalaCards View complete list of genes associated with diseases

Relevant External Links for JUND

Genetic Association Database (GAD)
JUND
Human Genome Epidemiology (HuGE) Navigator
JUND
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JUND
genes like me logo Genes that share disorders with JUND: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUND Gene

Publications for JUND Gene

  1. Structure and function of human jun-D. (PMID: 1903194) Berger I. … Shaul Y. (Oncogene 1991) 2 3 4 22 64
  2. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PMID: 2112242) Nomura N. … Ishizaki R. (Nucleic Acids Res. 1990) 2 3 4 64
  3. JunD and HIF-1alpha mediate transcriptional activation of angiotensinogen by TGF-beta1 in human lung fibroblasts. (PMID: 19211927) Abdul-Hafez A. … Uhal B.D. (FASEB J. 2009) 3 22 64
  4. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PMID: 18095154) Walker L.C. … Spurdle A.B. (Breast Cancer Res. Treat. 2008) 3 46 64
  5. Aberrant expression of Fra-2 promotes CCR4 expression and cell proliferation in adult T-cell leukemia. (PMID: 18071306) Nakayama T. … Yoshie O. (Oncogene 2008) 3 22 64

Products for JUND Gene

Sources for JUND Gene

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