Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



JUNB Gene

protein-coding   GIFtS: 64
GCID: GC19P012902

Jun B Proto-Oncogene

  See JUNB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Jun B Proto-Oncogene1 2
AP-12
Activator Protein 12
Transcription Factor Jun-B2

External Ids:    HGNC: 62051   Entrez Gene: 37262   Ensembl: ENSG000001712237   OMIM: 1651615   UniProtKB: P172753   

Export aliases for JUNB gene to outside databases

Previous GC identifers: GC19P013033 GC19P013125 GC19P012747 GC19P012763 GC19P012474


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for JUNB Gene:
JUNB (jun B proto-oncogene) is a protein-coding gene. Diseases associated with JUNB include fumarate hydratase deficiency. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275
Function: Transcription factor involved in regulating gene activity following the primary growth factor response.
Binds to the DNA sequence 5'-TGA[CG]TCA-3'

Gene Wiki entry for JUNB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the JUNB gene promoter:
         SRF   AP-1   Egr-1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJUNB promoter sequence
   Search Chromatin IP Primers for JUNB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JUNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

JUNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUNB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012902:  view genomic region     (about GC identifiers)

Start:
12,902,310 bp from pter      End:
12,904,125 bp from pter
Size:
1,816 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275 (See protein sequence)
Recommended Name: Transcription factor jun-B  
Size: 347 amino acids; 35879 Da
Subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with
ITCH (via its WW domains)
Secondary accessions: Q96GH3

Explore the universe of human proteins at neXtProt for JUNB: NX_P17275

Explore proteomics data for JUNB at MOPED

Post-translational modifications: 

  • Ubiquitinated by ITCH, leading to its degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JUNB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002220.1  
    ENSEMBL proteins: 
     ENSP00000303315  
    Reactome Protein details: P17275

    JUNB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for JUNB
    OriGene Protein Over-expression Lysate for JUNB
    OriGene MassSpec for JUNB
    OriGene Custom Protein Services for JUNB
    GenScript Custom Purified and Recombinant Proteins Services for JUNB
    Novus Biologicals JUNB Proteins
    Novus Biologicals JUNB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JUNB

     
    Search eBioscience for Proteins for JUNB 

     
    antibodies-online proteins for JUNB (6 products) 

     
    antibodies-online peptides for JUNB

    JUNB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of JUNB
    R&D Systems Antibodies for JUNB
    Cell Signaling Technology (CST) Antibodies for JUNB 
    OriGene Antibodies for JUNB
    OriGene Custom Antibody Services for JUNB
    Novus Biologicals JUNB Antibodies
    Abcam antibodies for JUNB
    Cloud-Clone Corp. Antibodies for JUNB
    ThermoFisher Antibodies for JUNB
    antibodies-online antibodies for JUNB (163 products) 

    JUNB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for JUNB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JUNB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JUNB
    Cloud-Clone Corp. CLIAs for JUNB
    Search eBioscience for ELISAs for JUNB 
    antibodies-online kits for JUNB (12 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    4 InterPro protein domains:
     IPR002112 Leuzip_Jun
     IPR004827 bZIP
     IPR008917 TF_DNA-bd
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P17275

    ProtoNet protein and cluster: P17275

    3 Blocks protein domains:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with JUNB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JUNB_HUMAN, P17275
    Function: Transcription factor involved in regulating gene activity following the primary growth factor response.
    Binds to the DNA sequence 5'-TGA[CG]TCA-3'
    Induction: By growth factors

         Genatlas biochemistry entry for JUNB:
    jun protooncogene homolog B,ligand induced,immediate (primary) early response gene

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding TAS10764760
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS2513129
         
    Find genes that share ontologies with JUNB           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Junb):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  renal/urinary system  skeleton 
     tumorigenesis 

    Find genes that share phenotypes with JUNB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Junbtm1Wag for JUNB

       genOway: Develop your customized and physiologically relevant rodent model for JUNB

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for JUNB (see all 2409):
    A2ML1,  A4GALT,  AAA1,  AAAS,  AATF,  ABCA1,  ABCA12,  ABCA9,  ABCB1,  ABCB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target JUNB:
    hsa-mir-199a-5p (MIRT004391), hsa-mir-663a (MIRT005353), hsa-mir-199a-3p (MIRT000783), hsa-mir-155-5p (MIRT020720), hsa-mir-1226-3p (MIRT036441)

    Block miRNA regulation of human, mouse, rat JUNB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JUNB (see all 27):
    hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidJUNB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for JUNB
    Predesigned siRNA for gene silencing in human, mouse, rat JUNB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JUNB

    Clone
    Products:
         
    OriGene clones in human, mouse for JUNB (see all 7)
    OriGene ORF clones in mouse, rat for JUNB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JUNB (NM_002229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB
    Addgene plasmids for JUNB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JUNB
    Browse ESI BIO Cell Lines and PureStem Progenitors for JUNB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUNB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    JUNB_HUMAN, P17275: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS2513129
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with JUNB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for JUNB About   (see all 37)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48
    3G protein signaling Ras family GTPases in kinase cascades scheme
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    4Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    Signaling by TGF-beta Receptor Complex0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    5Immune response IL 2 activation and signaling pathway
    Immune response IL 3 activation and signaling pathway0.41
    Immune response IL 2 activation and signaling pathway0.41


    Find genes that share SuperPaths with JUNB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for JUNB (see all 10)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for JUNB (see all 7)
        iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling
    ITK and TCR Signaling

    3 Cell Signaling Technology (CST) Pathways for JUNB
        MAP Kinase Signaling
    Lymphocyte Signaling
    DNA Damage

    Selected GeneGo (Thomson Reuters) Pathways for JUNB (see all 9)
        Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response IL-3 activation and signaling pathway

    Selected BioSystems Pathways for JUNB (see all 11)
        Oxidative Stress
    Oncostatin M Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    Corticotropin-releasing hormone

    1 Reactome Pathway for JUNB
        SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

    1 PharmGKB Pathway for JUNB
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for JUNB):
        Osteoclast differentiation
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUNB (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JUNB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JUNB (P172751, 2, 3 ENSP000003033154) via UniProtKB, MINT, STRING, and/or I2D (see all 266)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSP011001, 2, 3, ENSP000003062454EBI-748062,EBI-852851 MINT-1788374 I2D: score=7 STRING: ENSP00000306245
    ATF7P175442, 3MINT-6699684 MINT-6699624 I2D: score=1 
    C19orf68Q86XI81, 3EBI-748062,EBI-2682158 I2D: score=1 
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=2 STRING: ENSP00000267569
    UBCP0CG482, 3, ENSP000003448184MINT-7104258 I2D: score=3 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001701in utero embryonic development ----
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0006351transcription, DNA-templated TAS--

    Find genes that share ontologies with JUNB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JUNB

    Selected Novoseek inferred chemical compound relationships for JUNB gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sch 39166 68.7 2 7755894 (1), 8078918 (1)
    12-o-tetradecanoylphorbol 13-acetate 68.2 22 2007095 (6), 11751871 (1), 8389757 (1), 8180129 (1) (see all 14)
    phorbol 56.2 4 1496019 (2), 10098722 (1), 7759510 (1)
    okadaic acid 51 13 7848922 (4), 1662987 (2), 1851743 (1), 8706012 (1) (see all 5)
    leucine 41.7 5 9737720 (1), 16829632 (1), 8423806 (1), 12183893 (1) (see all 5)
    cycloheximide 37.1 3 7923384 (1), 7761104 (1), 2122229 (1)
    pd 98,059 36 3 9467952 (1), 10762717 (1), 15666830 (1)
    threonine 32.7 2 8398901 (1), 1662987 (1)
    retinoic acid 28.7 5 7977784 (1), 8375477 (1), 1837351 (1), 1963081 (1)
    tyrosine 28 14 8360477 (2), 2168557 (2), 8398901 (1), 9202212 (1) (see all 12)



    Find genes that share compounds with JUNB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for JUNB gene: 
    NM_002229.2  

    Unigene Cluster for JUNB:

    Jun B proto-oncogene
    Hs.25292  [show with all ESTs]
    Unigene Representative Sequence: NM_002229
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302754(uc002mvc.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat JUNB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JUNB (see all 27):
    hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidJUNB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for JUNB
    Predesigned siRNA for gene silencing in human, mouse, rat JUNB
    Clone
    Products:
         
    OriGene clones in human, mouse for JUNB (see all 7)
    OriGene ORF clones in mouse, rat for JUNB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JUNB (NM_002229)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB
    Addgene plasmids for JUNB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for JUNB
    OriGene qSTAR qPCR primer pairs in human, mouse for JUNB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JUNB
      QuantiTect SYBR Green Assays in human, mouse, rat JUNB
      QuantiFast Probe-based Assays in human, mouse, rat JUNB

    Additional mRNA sequence: 

    AK222532.1 AK313737.1 BC004250.1 BC009465.1 BC009466.1 BC110372.1 BT019760.1 DQ650707.1 
    X51345.1 

    Selected DOTS entries (see all 30):

    DT.70104738  DT.100887173  DT.100039569  DT.100887176  DT.100835777  DT.121433813  DT.100887182  DT.100039570 
    DT.100887197  DT.100887199  DT.100887209  DT.100759023  DT.100834577  DT.121433760  DT.121640449  DT.121433754 
    DT.97857103  DT.100887188  DT.100887203  DT.121433869  DT.121433872  DT.121433880  DT.121433886  DT.95359451 

    Selected AceView cDNA sequences (see all 667):

    AI433149 BM784880 BM677858 AA456440 CR604051 CR620377 BM556945 CD519437 
    AA806502 AU134102 NM_002229 CF242856 BM904126 CA440137 CR601699 CR606286 
    AW513439 CR614974 BM760202 CN483480 CD365138 AI871478 CR590747 AW571947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    JUNB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCACGTCA
    JUNB Expression
    About this image


    JUNB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
             Secondary follicles
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    JUNB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JUNB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.25292
        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUNB (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for JUNB
    OriGene qSTAR qPCR primer pairs in human, mouse for JUNB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JUNB
    QuantiTect SYBR Green Assays in human, mouse, rat JUNB
    QuantiFast Probe-based Assays in human, mouse, rat JUNB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUNB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for JUNB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Junb1 , 5 Jun-B oncogene5
    jun B proto-oncogene1
    88.95(n)1
    93.6(a)1
      8 (41.41 cM)5
    164771  NM_008416.31  NP_032442.11 
     849769095 
    lizard
    (Anolis carolinensis)
    Reptilia JUNB6
    jun B proto-oncogene
    47(a)
    1 ↔ 1
    GL343286.1(972344-972877)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia junb1 jun B proto-oncogene 60(n)
    59.66(a)
      733713  NM_001044490.1  NP_001037955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii junba6
    junbb6
    jun B proto-oncogene b
    58(a)
    55(a)
    1 ↔ many
    1 ↔ many
    1(52226931-52228487) ENSDARG00000074378
    3(8434976-8436380) ENSDARG00000088371
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    30(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUNB (if available)
    TreeFam Gene Tree for JUNB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for JUNB gene
    JUND2  JUN2  
    3 SIMAP similar genes for JUNB using alignment to 3 protein entries:     JUNB_HUMAN (see all proteins):
    RNASEH2A    JUN    JUND

    Find genes that share paralogs with JUNB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for JUNB (see all 85)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104058301,2
    C--12900796(+) GGGGCC/TGGCCC 1 -- us2k10--------
    rs1892350561,2
    --12901302(+) TGGGGC/GACAGA 1 -- us2k10--------
    rs1815883331,2
    --12901318(+) CAGATA/GACTAA 1 -- us2k10--------
    rs1865249431,2
    --12901324(+) ACTAAC/GAGGTT 1 -- us2k10--------
    rs169786691,2
    F--12901468(+) CTAACT/ACTCTC 1 -- us2k1 trp32Minor allele frequency- A:0.00MN EA 356
    rs1822449691,2
    --12901488(+) GGCTAC/GCAGAT 1 -- us2k10--------
    rs1138296551,2
    C--12901498(+) GACCCCAATTT  
      CTGG
    /-
    CAGTG
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs178814321,2
    C,F--12901500(+) CCCCA-/ATTT  
      CTGGCA
    GTGGT
    1 -- us2k11Minor allele frequency- ATTTCTGGCA:0.04NS 168
    rs178784681,2
    C,F,H--12901511(+) CCCCAA/GTTTCT 1 -- us2k110Minor allele frequency- G:0.10NS NA WA CSA 1180
    rs776474551,2
    F--12901629(+) CGCTTA/GCGGGA 1 -- us2k11Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for JUNB (12902310 - 12904125 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for JUNB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911077CNV Loss21882294
    nsv911079CNV Loss21882294
    dgv3733n71CNV Loss21882294
    dgv3734n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing JUNB:
    Oncogenes & Tumor Suppressor Genes 384HC
    SeqTarget long-range PCR primers for resequencing JUNB
    DNA2.0 Custom Variant and Variant Library Synthesis for JUNB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 165161    OMIM disorders: --

    1 disease for JUNB:    
    About MalaCards
    fumarate hydratase deficiency


    Find genes that share disorders with JUNB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for JUNB gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 51.3 2 12937177 (1), 17306025 (1)
    myeloid leukemia 48.9 7 2122229 (2), 1373742 (2), 2007095 (1), 16618766 (1) (see all 5)
    anaplastic large cell lymphoma 44.9 9 15920551 (3), 17965727 (2), 16140928 (2), 15377339 (1)
    hodgkin disease 33.3 10 15920551 (2), 17965727 (2), 12145210 (2), 16140928 (2) (see all 6)
    myeloproliferative disorders 29 4 15507213 (2), 16024645 (1), 12506033 (1)
    tumors 26.6 30 17009623 (3), 8649827 (2), 10502734 (2), 1404666 (2) (see all 19)
    myeloid leukemia chronic 26.3 6 12506033 (2), 10714213 (1), 15507213 (1), 20030915 (1) (see all 5)
    blast crisis 24.7 2 18346528 (1), 12506033 (1)
    necrosis 23.1 5 9528756 (1), 1404666 (1), 8631909 (1)
    neoplastic transformation 22.1 2 10874008 (1), 12506033 (1)

    Genetic Association Database (GAD): JUNB
    Human Genome Epidemiology (HuGE) Navigator: JUNB (3 documents)

    Export disorders for JUNB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for JUNB gene, integrated from 10 sources (see all 447):
    (articles sorted by number of sources associating them with JUNB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. jun-B inhibits and c-fos stimulates the transforming and trans- activating activities of c-jun. (PubMed id 2513129)1, 2, 3 Schuette J.... Minna J. (Cell 1989)
    2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. (PubMed id 8530030)1, 2 Phinney D.G.... Ryder K. (Genomics 1995)
    6. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)1, 2 Nomura N.... Ishizaki R. (Nucleic Acids Res. 1990)
    7. JunB inhibits proliferation and transformation in B-lymphoid cells. (PubMed id 12907453)1, 9 Szremska A.P....Sexl V. (Blood 2003)
    8. [Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells]. (PubMed id 20030915)1, 9 Wang X.J....Huang S.A. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    9. Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region. (PubMed id 12522006)1, 9 Liu H....Friedman A.D. (Blood 2003)
    10. JunB gene expression is inactivated by methylation in chronic myeloid leukemia. (PubMed id 12506033)1, 9 Yang M.Y....Lin S.F. (Blood 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3726 HGNC: 6205 AceView: JUNB Ensembl:ENSG00000171223 euGenes: HUgn3726
    ECgene: JUNB Kegg: 3726 H-InvDB: JUNB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for JUNB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUNB Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/junb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for JUNB gene:
    Search GeneIP for patents involving JUNB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of JUNB
     
     EMD Millipore genomic analysis products

      
     Antibodies for JUNB (JunB)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for JUNB   OriGene RNAi products in human, mouse, rat for JUNB  
     OriGene qPCR primer pairs and template standards for JUNB   OriGene Protein Over-expression Lysate for JUNB  
     OriGene MassSpec for JUNB   OriGene clones in human, mouse for JUNB  
     OriGene qSTAR qPCR primer pairs in human, mouse for JUNB   OriGene Purified Protein for JUNB  
     OriGene ORF clones in mouse, rat for JUNB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for JUNB   OriGene Custom Protein Services for JUNB  

     
     
     Block miRNA regulation of human, mouse, rat JUNB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing JUNB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JUNB Predesigned siRNA for gene silencing in human, mouse, rat JUNB
     QuantiFast Probe-based Assays in human, mouse, rat JUNB QuantiTect SYBR Green Assays in human, mouse, rat JUNB
     PCR Arrays including human, mouse, rat JUNB Search Chromatin IP Primers for JUNB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JUNB  GeneGlobe Interaction Network for JUNB
     Regulatory tfbs in JUNB promoter
     GenScript Custom Purified and Recombinant Proteins Services for JUNB GenScript cDNA clones with any tag delivered in your preferred vector for JUNB
     GenScript Custom Assay Services for JUNB GenScript Custom overexpressing Cell Line Services for JUNB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for JUNB 

     Search Tocris compounds for JUNB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     JUNB antibodies
     JUNB proteins
     JUNB lysates
     Antibodies for JUNB
     See all of Abcam's Antibodies, Kits and Proteins for JUNB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for JUNB
     Antibodies for JUNB
     ELISAs for JUNB
     CLIAs for JUNB



     Browse ESI BIO Cell Lines and PureStem Progenitors for JUNB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUNB
     SwitchGear 3'UTR luciferase reporter plasmids for JUNB
     SwitchGear Promoter luciferase reporter plasmids for JUNB
     ThermoFisher Antibodies for JUNB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB
     Browse compounds at ApexBio
     Addgene plasmids for JUNB
      Search eBioscience for proteins for JUNB
      Search eBioscience for elisas for JUNB
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for JUNB
     antibodies-online antibodies for JUNB (163 products)
     antibodies-online kits for JUNB (12 products)
     antibodies-online peptides for JUNB
     antibodies-online proteins for JUNB (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      JUNB gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4