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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JUNB Gene

protein-coding   GIFtS: 65
GCID: GC19P012902

Jun B Proto-Oncogene

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Jun B Proto-Oncogene1 2
AP-12
Activator Protein 12
Transcription Factor Jun-B2

External Ids:    HGNC: 62051   Entrez Gene: 37262   Ensembl: ENSG000001712237   OMIM: 1651615   UniProtKB: P172753   

Export aliases for JUNB gene to outside databases

Previous GC identifers: GC19P013033 GC19P013125 GC19P012747 GC19P012763 GC19P012474


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for JUNB Gene: 
JUNB (jun B proto-oncogene) is a protein-coding gene. Diseases associated with JUNB include cascade stomach, and anaplastic large cell lymphoma, and among its related super-pathways are Mucin expression in CF via IL-6, IL-17 signaling pathways and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275
Function: Transcription factor involved in regulating gene activity following the primary growth factor response.
Binds to the DNA sequence 5'-TGA[CG]TCA-3'

Gene Wiki entry for JUNB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JUNB gene promoter:
         SRF   AP-1   Egr-1   SRF (504 AA)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJUNB promoter sequence
   Search SABiosciences Chromatin IP Primers for JUNB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

JUNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUNB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P012902:  view genomic region     (about GC identifiers)

Start:
12,902,310 bp from pter      End:
12,904,125 bp from pter
Size:
1,816 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275 (See protein sequence)
Recommended Name: Transcription factor jun-B  
Size: 347 amino acids; 35879 Da
Subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with
ITCH (via its WW domains)
Subcellular location: Nucleus
Secondary accessions: Q96GH3

Explore the universe of human proteins at neXtProt for JUNB: NX_P17275

Explore proteomics data for JUNB at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by ITCH, leading to its degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17275

  • JUNB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JUNB Protein Expression
    REFSEQ proteins: NP_002220.1  
    ENSEMBL proteins: 
     ENSP00000303315  
    Reactome Protein details: P17275
    Human Recombinant Protein Products for JUNB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for JUNB
    OriGene Protein Over-expression Lysate for JUNB
    OriGene MassSpec for JUNB 
    OriGene Custom Protein Services for JUNB
    GenScript Custom Purified and Recombinant Proteins Services for JUNB
    Novus Biologicals JUNB Proteins
    Novus Biologicals JUNB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JUNB 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin TAS2513129
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    JUNB for ontologies           About GeneDecksing



    JUNB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of JUNB
    R&D Systems Antibodies for JUNB
    Cell Signaling Technology (CST) Antibodies for JUNB 
    OriGene Antibodies for JUNB
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    GenScript Superior Antibodies for JUNB
    Novus Biologicals JUNB Antibodies
    Abcam antibodies for JUNB
    Cloud-Clone Corp. Antibodies for JUNB 
    ThermoFisher Antibodies for JUNB
    LSBio Antibodies in human, mouse, rat for JUNB 

    Assay Products for JUNB: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JUNB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JUNB 
    Cloud-Clone Corp. CLIAs for JUNB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    4 InterPro protein domains:
     IPR002112 Leuzip_Jun
     IPR004827 bZIP
     IPR008917 Euk_TF_DNA-bd
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P17275

    ProtoNet protein and cluster: P17275

    3 Blocks protein domains:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    JUNB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JUNB_HUMAN, P17275
    Function: Transcription factor involved in regulating gene activity following the primary growth factor response.
    Binds to the DNA sequence 5'-TGA[CG]TCA-3'
    Induction: By growth factors

         Genatlas biochemistry entry for JUNB:
    jun protooncogene homolog B,ligand induced,immediate (primary) early response gene

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding TAS10764760
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS2513129
         
    JUNB for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Junb):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  mortality/aging  renal/urinary system  skeleton 
     tumorigenesis 

    JUNB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Junbtm1Wag for JUNB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for JUNB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JUNB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JUNB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JUNB 

    10/2425 SABiosciences Target genes for JUNB (see all 2425):
    A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

    miRNA
    Products:
        
    miRTarBase miRNAs that target JUNB:
    hsa-mir-199a-5p (MIRT004391), hsa-mir-663 (MIRT005353), hsa-mir-199b-3p (MIRT004392)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUNB
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate JUNB (see all 27):
    hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidJUNB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for JUNB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUNB

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of JUNB

    Clone
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    OriGene ORF clones in mouse, rat for JUNB
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    GenScript: all cDNA clones in your preferred vector: JUNB (NM_002229)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB
    Sirion Biotech Customized lentivirus for stable overexpression of JUNB 
                         Customized lentivirus expression plasmids for stable overexpression of JUNB 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUNB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for JUNB About   (see all 35)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Mucin expression in CF via IL-6, IL-17 signaling pathways
    Mucin expression in CF via IL-6, IL-17 signaling pathways0.48
    Mucin expression in CF via TLRs, EGFR signaling pathways0.41
    IL-17 Signaling0.48
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    Oncostatin M Signaling Pathway0.37
    3Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41
    iNOS Signaling0.34
    4Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59
    Inflammasome Activation Pathways0.52
    NOD-like Receptor Signaling Pathways0.59
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    5Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Signaling by TGF-beta Receptor Complex0.61
    SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for JUNB (see all 7)
        Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Immune response CD16 signaling in NK cells
    Cell cycle Regulation of G1/S transition (part 1)
    Immune response IL-3 activation and signaling pathway
    Immune response Oncostatin M signaling via MAPK in human cells

    5/9 R&D Systems Pathways for JUNB (see all 9)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Signaling
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JUNB (see all 7)
        iNOS Signaling
    SMAD Signaling Network
    Ceramide Pathway
    ILK Signaling
    ITK and TCR Signaling

    3 Cell Signaling Technology (CST) Pathways for JUNB
        MAP Kinase Signaling
    Lymphocyte Signaling
    DNA Damage

    5/9 GeneGo (Thomson Reuters) Pathways for JUNB (see all 9)
        Immune response CD16 signaling in NK cells
    Mucin expression in CF via IL-6, IL-17 signaling pathways
    Immune response IL-2 activation and signaling pathway
    Mucin expression in CF via TLRs, EGFR signaling pathways
    Immune response IL-3 activation and signaling pathway

    5/10 BioSystems Pathways for JUNB (see all 10)
        Oxidative Stress
    Oncostatin M Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    Integrated Pancreatic Cancer Pathway
    ATF-2 transcription factor network

    5/6        Reactome Pathways for JUNB (see all 6)
        Signaling by TGF-beta Receptor Complex
    Generic Transcription Pathway
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signal Transduction
    Gene Expression

    1 PharmGKB Pathway for JUNB
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for JUNB):
        Osteoclast differentiation
    TNF signaling pathway


    JUNB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JUNB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for JUNB (P172751, 2, 3 ENSP000003033154) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7P175442, 3MINT-6699684 MINT-6699624 I2D: score=1 
    C19orf68Q86XI81, 3EBI-748062,EBI-2682158 I2D: score=1 
    JDP2Q8WYK22, 3, ENSP000002675694MINT-6699684 MINT-6699624 I2D: score=2 STRING: ENSP00000267569
    UBCP0CG482, 3, ENSP000003448184MINT-7104258 I2D: score=3 STRING: ENSP00000344818
    FOSP011002, 3, ENSP000003062454MINT-1788374 I2D: score=7 STRING: ENSP00000306245
    About this table

    Gene Ontology (GO): 5/32 biological process terms (GO ID links to tree view) (see all 32):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001649osteoblast differentiation IEA--
    GO:0001701in utero embryonic development ----
    GO:0001829trophectodermal cell differentiation IEA--
    GO:0006351transcription, DNA-dependent TAS--

    JUNB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    JUNB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JUNB

    10/57 Novoseek inferred chemical compound relationships for JUNB gene (see all 57)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sch 39166 68.7 2 7755894 (1), 8078918 (1)
    12-o-tetradecanoylphorbol 13-acetate 68.2 22 2007095 (6), 11751871 (1), 8389757 (1), 8180129 (1) (see all 14)
    phorbol 56.2 4 1496019 (2), 10098722 (1), 7759510 (1)
    okadaic acid 51 13 7848922 (4), 1662987 (2), 1851743 (1), 8706012 (1) (see all 5)
    leucine 41.7 5 9737720 (1), 16829632 (1), 8423806 (1), 12183893 (1) (see all 5)
    cycloheximide 37.1 3 7923384 (1), 7761104 (1), 2122229 (1)
    pd 98,059 36 3 9467952 (1), 10762717 (1), 15666830 (1)
    threonine 32.7 2 8398901 (1), 1662987 (1)
    retinoic acid 28.7 5 7977784 (1), 8375477 (1), 1837351 (1), 1963081 (1)
    tyrosine 28 14 8360477 (2), 2168557 (2), 8398901 (1), 9202212 (1) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about JUNB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JUNB gene: 
    NM_002229.2  

    Unigene Cluster for JUNB:

    Jun B proto-oncogene
    Hs.25292  [show with all ESTs]
    Unigene Representative Sequence: NM_002229
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302754(uc002mvc.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUNB
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate JUNB (see all 27):
    hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidJUNB 3' UTR sequence
    Inhib. RNA
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB
    Sirion Biotech Customized lentivirus for stable overexpression of JUNB 
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JUNB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUNB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUNB

    Additional mRNA sequence: 

    AK222532.1 AK313737.1 BC004250.1 BC009465.1 BC009466.1 BC110372.1 BT019760.1 DQ650707.1 
    X51345.1 

    24/30 DOTS entries (see all 30):

    DT.70104738  DT.100887173  DT.100039569  DT.100887176  DT.100835777  DT.121433813  DT.100887182  DT.100039570 
    DT.100887197  DT.100887199  DT.100887209  DT.100759023  DT.100834577  DT.121433760  DT.121640449  DT.121433754 
    DT.97857103  DT.100887188  DT.100887203  DT.121433869  DT.121433872  DT.121433880  DT.121433886  DT.95359451 

    24/667 AceView cDNA sequences (see all 667):

    BF725562 BQ575642 BM910865 CA416964 CA412329 BC004250 CA389907 CR626547 
    BM784880 CR613405 CB307002 BM457825 BM791292 CR611695 BE858851 CD365533 
    BM997963 AA806502 AI918357 CR594713 AA046285 CR612733 BX100858 CF129444 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JUNB expression in normal human tissues (normalized intensities)      JUNB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCACGTCA
    JUNB Expression
    About this image


    JUNB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Secondary follicles
             ovary ; follicle cells   

    See JUNB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JUNB

    SOURCE GeneReport for Unigene cluster: Hs.25292
        SABiosciences Expression via Pathway-Focused PCR Arrays including JUNB (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Leukemia in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUNB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for JUNB gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Junb1 , 5 Jun-B oncogene1, 5 89.15(n)1
    93.9(a)1
      8 (41.41 cM)5
    164771  NM_008416.31  NP_032442.11 
     849769095 
    lizard
    (Anolis carolinensis)
    Reptilia JUNB6
    --
    --
    46(a)
    33(a)
    1 ↔ 1
    possible ortholog
    GL343286.1(972344-972877)
    GL343339.1(866076-867101)
    zebrafish
    (Danio rerio)
    Actinopterygii junba1 jun B proto-oncogene a 66.67(n)
    63.55(a)
      407086  NM_213556.3  NP_998721.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    30(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUNB (if available)
    TreeFam Gene Tree for JUNB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JUNB gene
    JUND2  JUN2  
    3 SIMAP similar genes for JUNB using alignment to 3 protein entries:     JUNB_HUMAN (see all proteins):
    RNASEH2A    JUN    JUND

    JUNB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/85 SNPs in JUNB are shown (see all 85)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104058301,2
    C--12900796(+) GGGGCC/TGGCCC 1 -- us2k10--------
    rs1892350561,2
    --12901302(+) TGGGGC/GACAGA 1 -- us2k10--------
    rs1815883331,2
    --12901318(+) CAGATA/GACTAA 1 -- us2k10--------
    rs1865249431,2
    --12901324(+) ACTAAC/GAGGTT 1 -- us2k10--------
    rs169786691,2
    F--12901468(+) CTAACT/ACTCTC 1 -- us2k1 trp32Minor allele frequency- A:0.00MN EA 356
    rs1822449691,2
    --12901488(+) GGCTAC/GCAGAT 1 -- us2k10--------
    rs1138296551,2
    C--12901498(+) GACCCCAATTT  
      CTGG
    /-
    CAGTG
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs178814321,2
    C,F--12901500(+) CCCCA-/ATTT  
      CTGGCA
    GTGGT
    1 -- us2k11Minor allele frequency- ATTTCTGGCA:0.04NS 168
    rs178784681,2
    C,F,H--12901511(+) CCCCAA/GTTTCT 1 -- us2k110Minor allele frequency- G:0.10NS NA WA CSA 1180
    rs776474551,2
    F--12901629(+) CGCTTA/GCGGGA 1 -- us2k11Minor allele frequency- G:0.09WA 118

    HapMap Linkage Disequilibrium report for JUNB (12902310 - 12904125 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for JUNB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911077CNV Loss21882294
    nsv911079CNV Loss21882294
    dgv3733n71CNV Loss21882294
    dgv3734n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for JUNB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 165161    OMIM disorders: --

    20/46 diseases for JUNB (see all 46):    About MalaCards
    cascade stomach    anaplastic large cell lymphoma    splenic marginal zone lymphoma    lymphomatoid papulosis
    cutaneous t cell lymphoma    chronic myeloid leukemia    familial breast cancer    human t-cell leukemia virus type 1
    cervical cancer    thymoma    pheochromocytoma    osteoarthritis
    conjunctivitis    myeloid leukemia    osteosarcoma    leiomyoma
    oral cancer    t-cell leukemia    fibrosarcoma    stomach cancer


    JUNB for disorders           About GeneDecksing

    10/39 Novoseek inferred disease relationships for JUNB gene (see all 39)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia t-cell 51.3 2 12937177 (1), 17306025 (1)
    myeloid leukemia 48.9 7 2122229 (2), 1373742 (2), 2007095 (1), 16618766 (1) (see all 5)
    anaplastic large cell lymphoma 44.9 9 15920551 (3), 17965727 (2), 16140928 (2), 15377339 (1)
    hodgkin disease 33.3 10 15920551 (2), 17965727 (2), 12145210 (2), 16140928 (2) (see all 6)
    myeloproliferative disorders 29 4 15507213 (2), 16024645 (1), 12506033 (1)
    tumors 26.6 30 17009623 (3), 8649827 (2), 10502734 (2), 1404666 (2) (see all 19)
    myeloid leukemia chronic 26.3 6 12506033 (2), 10714213 (1), 15507213 (1), 20030915 (1) (see all 5)
    blast crisis 24.7 2 18346528 (1), 12506033 (1)
    necrosis 23.1 5 9528756 (1), 1404666 (1), 8631909 (1)
    neoplastic transformation 22.1 2 10874008 (1), 12506033 (1)

    Genetic Association Database (GAD): JUNB
    Human Genome Epidemiology (HuGE) Navigator: JUNB (3 documents)

    Export disorders for JUNB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JUNB gene, integrated from 9 sources (see all 442):
    (articles sorted by number of sources associating them with JUNB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. jun-B inhibits and c-fos stimulates the transforming and trans- activating activities of c-jun. (PubMed id 2513129)1, 2, 3 Schuette J.... Minna J. (1989)
    2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. (PubMed id 8530030)1, 2 Phinney D.G.... Ryder K. (1995)
    6. Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)1, 2 Nomura N.... Ishizaki R. (1990)
    7. JunB inhibits proliferation and transformation in B-lymphoid cells. (PubMed id 12907453)1, 9 Szremska A.P....Sexl V. (2003)
    8. [Methylation status of JunB and CDH13 gene promoter i n CD34(+)CD38(-) chronic myelogenous leukemia cells] (PubMed id 20030915)1, 9 Wang X.J....Huang S.A. (2009)
    9. Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region. (PubMed id 12522006)1, 9 Liu H....Friedman A.D. (2003)
    10. JunB gene expression is inactivated by methylation in chronic myeloid leukemia. (PubMed id 12506033)1, 9 Yang M.Y....Lin S.F. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3726 HGNC: 6205 AceView: JUNB Ensembl:ENSG00000171223 euGenes: HUgn3726
    ECgene: JUNB Kegg: 3726 H-InvDB: JUNB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JUNB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUNB Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/junb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JUNB gene:
    Search GeneIP for patents involving JUNB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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