Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

JUNB Gene

protein-coding GIFtS: 63
GCID: GC19P012902

jun B proto-oncogene

Explore 46 diseases affiliated with
JUNB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Jun B Proto-Oncogene¹ ²
AP-1²
Activator Protein 1²
Transcription Factor Jun-B²

External Ids:	HGNC: 6205¹	Entrez Gene: 3726²	Ensembl: ENSG00000171223⁷	OMIM: 165161⁵	UniProtKB: P17275³

Export aliases for JUNB gene to outside databases

Previous GC identifers: GC19P013033 GC19P013125 GC19P012747 GC19P012763 GC19P012474

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275

Function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds

to the DNA sequence 5'-TGA[CG]TCA-3'

Gene Wiki entry for JUNB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the JUNB gene promoter:
SRF AP-1 Egr-1 SRF (504 AA)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JUNB promoter sequence

Search SABiosciences Chromatin IP Primers for JUNB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUNB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.13

JUNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUNB gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P012902: view genomic region (about GC identifiers)

Start:	12,902,310 bp from pter	End:	12,904,125 bp from pter
Size:	1,816 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275 (See protein sequence)

Recommended Name: Transcription factor jun-B

Size: 347 amino acids; 35879 Da

Subunit: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH

(via its WW domains)

Subcellular location: Nucleus

Secondary accessions: Q96GH3

Explore the universe of human proteins at neXtProt for JUNB: NX_P17275

Post-translational modifications:

Ubiquitinated by ITCH, leading to its degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17275

JUNB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002220.1

ENSEMBL proteins:

ENSP00000303315

Reactome Protein details: P17275
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: JUNB OriGene Protein Over-expression Lysate: JUNB OriGene Custom Protein Services for JUNB
	GenScript Custom Purified and Recombinant Proteins Services for JUNB
	Novus Biologicals JUNB Proteins Novus Biologicals JUNB Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for JUNB

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	TAS	2513129
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--

JUNB for ontologies About GeneDecksing

JUNB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of JUNB
	R&D Systems Antibodies for JUNB
	Cell Signaling Technology (CST) Antibodies for JUNB
	OriGene Antibodies (see all 4): JUNB OriGene Custom Antibody Services for JUNB
	GenScript Superior Antibodies for JUNB
	Novus Biologicals JUNB Antibodies
	Abcam antibodies for JUNB
	Uscn Antibodies for JUNB
	ThermoFisher Antibody for JUNB

Assay Products for JUNB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for JUNB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for JUNB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

JUNB for domains About GeneDecksing

4 InterPro domains/families:

IPR004827 bZIP

IPR008917 Euk_TF_DNA-bd

IPR002112 Leuzip_Jun

IPR005643 JNK

Graphical View of Domain Structure for InterPro Entry P17275

ProtoNet protein and cluster: P17275

3 Blocks protein families:

IPB002112 Jun transcription factor signature

IPB005643 Jun-like transcription factor

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275

Similarity: Belongs to the bZIP family. Jun subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: JUNB_HUMAN, P17275

Function: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds

to the DNA sequence 5'-TGA[CG]TCA-3'

Induction: By growth factors

Genatlas biochemistry entry for JUNB:

jun protooncogene homolog B,ligand induced,immediate (primary) early response gene

		10/2460 SABiosciences Target genes for JUNB (see all 2460):
		A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

miRNA Products:		miRTarBase miRNAs that target JUNB: hsa-mir-199a-5p (MIRT004391), hsa-mir-663 (MIRT005353), hsa-mir-199b-3p (MIRT004392)

		OriGene 3'-UTR Clone: JUNB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUNB
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate JUNB (see all 27):
		hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: JUNB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUNB (see all 7) OriGene shRNA RFP: JUNB OriGene siRNA: JUNB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUNB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for JUNB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: JUNB (NM_002229)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for JUNB
		Search LifeMap BioReagents cell lines for JUNB

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for JUNB

Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IEA	--
GO:0003677	DNA binding	TAS	10764760
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003713	transcription coactivator activity	TAS	2513129

JUNB for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Junb^tm2Wag for JUNB
     11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Junb):

cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism	immune system
integument	limbs/digits/tail	mortality/aging	renal/urinary system	skeleton
tumorigenesis

JUNB for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

	Immune response IL-2 activation and signaling pathway	1.00			Immune response_IL-3 activation and signaling pathway	0.41
	Immune response_IL-2 activation and signaling pathway	1.00			Immune response IL-3 activation and signaling pathway	0.41

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

	Immune response Oncostatin M signaling via MAPK in human cells	0.39			Oncostatin M Signaling Pathway	0.15
	Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Immune response_IL-1 signaling pathway

Immune response_IL-1 signaling pathway

1.00

Immune response IL-1 signaling pathway

0.98

Mucin expression in CF via IL-6, IL-17 signaling pathways

Mucin expression in CF via IL-6, IL-17 signaling pathways

1.00

Mucin expression in CF via TLRs, EGFR signaling pathways

0.41

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for JUNB (see all 7)

	Development Growth hormone signaling via PI3K/AKT and MAPK cascades
	Immune response CD16 signaling in NK cells
	Cell cycle Regulation of G1/S transition (part 1)
	Immune response IL-3 activation and signaling pathway
	Immune response Oncostatin M signaling via MAPK in human cells

5 R&D Systems Pathways for JUNB

	Inflammasome Activation Pathways
	Adipocytokines & Insulin Signaling
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	TGF-beta Signaling Pathways

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JUNB (see all 7)

	iNOS Signaling
	SMAD Signaling Network
	Ceramide Pathway
	ILK Signaling
	ITK and TCR Signaling

3 Cell Signaling Technology (CST) Pathways for JUNB

	MAP Kinase Signaling
	Lymphocyte Signaling
	DNA Damage

5/9 GeneGo (Thomson Reuters) Pathways for JUNB (see all 9)

	Immune response CD16 signaling in NK cells
	Mucin expression in CF via IL-6, IL-17 signaling pathways
	Immune response IL-2 activation and signaling pathway
	Mucin expression in CF via TLRs, EGFR signaling pathways
	Immune response IL-3 activation and signaling pathway

5/11 BioSystems Pathways for JUNB (see all 11)

	Oncostatin M Signaling Pathway
	TGF-beta Receptor Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	ATF-2 transcription factor network

5/7 Reactome Pathways for JUNB (see all 7)

	SMAD2/3:SMAD4 complex positively regulates JUNB transcription
	Signaling by TGF-beta Receptor Complex
	Generic Transcription Pathway
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Signal Transduction

1 PharmGKB Pathway for JUNB

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for JUNB):

Osteoclast differentiation

JUNB for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for JUNB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/101 Interacting proteins for JUNB (P17275^{1, 2, 3} ENSP00000303315⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 101)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOS	P01100²^,³, ENSP00000306245⁴	MINT-1788374 I2D: score=7 STRING: ENSP00000306245
ATF7	P17544²^,³	MINT-6699684 MINT-6699624 I2D: score=1
C19orf68	Q86XI8¹^,³	EBI-748062,EBI-2682158 I2D: score=1
JDP2	Q8WYK2²^,³, ENSP00000267569⁴	MINT-6699684 MINT-6699624 I2D: score=2 STRING: ENSP00000267569
UBC	P0CG48²^,³, ENSP00000344818⁴	MINT-7104258 I2D: score=3 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IEA	--
GO:0001649	osteoblast differentiation	IEA	--
GO:0001701	in utero embryonic development	--	--
GO:0001829	trophectodermal cell differentiation	IEA	--
GO:0006351	transcription, DNA-dependent	TAS	--

JUNB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

JUNB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for JUNB
10/57 Novoseek chemical compound relationships for JUNB gene (see all 57) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sch 39166	68.7	2	7755894 (1), 8078918 (1)
12-o-tetradecanoylphorbol 13-acetate	68.2	22	2007095 (6), 11751871 (1), 8389757 (1), 8180129 (1) (see all 14)
phorbol	56.2	4	1496019 (2), 10098722 (1), 7759510 (1)
okadaic acid	51	13	7848922 (4), 1662987 (2), 1851743 (1), 8706012 (1) (see all 5)
leucine	41.7	5	9737720 (1), 16829632 (1), 8423806 (1), 12183893 (1) (see all 5)
cycloheximide	37.1	3	7923384 (1), 7761104 (1), 2122229 (1)
pd 98,059	36	3	9467952 (1), 10762717 (1), 15666830 (1)
threonine	32.7	2	8398901 (1), 1662987 (1)
retinoic acid	28.7	5	7977784 (1), 8375477 (1), 1837351 (1), 1963081 (1)
tyrosine	28	14	8360477 (2), 2168557 (2), 8398901 (1), 9202212 (1) (see all 12)

Search CenterWatch for drugs/clinical trials and news about JUNB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for JUNB gene:

NM_002229.2

Unigene Cluster for JUNB:

Jun B proto-oncogene

Hs.25292 [show with all ESTs]

Unigene Representative Sequence: NM_002229

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000302754(uc002mvc.3)

miRNA Products:		OriGene 3'-UTR Clone: JUNB Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUNB
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate JUNB (see all 27):
		hsa-miR-3678-3p hsa-miR-30c hsa-miR-16-2* hsa-miR-4272 hsa-miR-1908 hsa-miR-30d hsa-miR-3133 hsa-miR-4267

		SwitchGear 3'UTR luciferase reporter plasmid: JUNB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUNB (see all 7) OriGene shRNA RFP: JUNB OriGene siRNA: JUNB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUNB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: JUNB (NM_002229)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUNB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JUNB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat JUNB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUNB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUNB

Additional cDNA sequence:

AK222532.1 AK313737.1 BC004250.1 BC009465.1 BC009466.1 BC110372.1 BT019760.1 DQ650707.1

X51345.1

24/30 DOTS entries (see all 30):

DT.70104738 DT.100887173 DT.100039569 DT.100887176 DT.100835777 DT.121433813 DT.100887182 DT.100039570

DT.100887197 DT.100887199 DT.100887209 DT.100759023 DT.100834577 DT.121433760 DT.121640449 DT.121433754

DT.97857103 DT.100887188 DT.100887203 DT.121433869 DT.121433872 DT.121433880 DT.121433886 DT.95359451

24/667 AceView cDNA sequences (see all 667):

CR626547 CR590747 CA416964 CA440137 CR610072 CR604051 BM460159 CF242856

CA412329 CR612733 AA398946 BM128208 CK819234 CB266628 CR624580 R74523

H91100 CR602325 BU682557 AI090192 BM789624 BQ575642 CR594713 BC004250

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

JUNB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCACGTCA

About this image

JUNB expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See JUNB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JUNB

SOURCE GeneReport for Unigene cluster: Hs.25292

SABiosciences Expression via Pathway-Focused PCR Arrays including JUNB (see all 10):

Oncogenes & Tumor Suppressor Genes in human mouse rat

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Leukemia in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JUNB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat JUNB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUNB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUNB

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for JUNB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for JUNB gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	JUNB⁶	--	47(a)	1 ↔ 1	GL343286.1(972344-972877)
zebrafish (Danio rerio)	Actinopterygii	junba¹	jun B proto-oncogene a	66.67(n) 63.55(a)		407086 NM_213556.3 NP_998721.2
fruit fly (Drosophila melanogaster)	Insecta	Jra⁶	Jun-related antigen	31(a)	1 → many	2R(5983985-5986061)

ENSEMBL Gene Tree for JUNB (if available)
TreeFam Gene Tree for JUNB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for JUNB gene

JUND² JUN²

3 SIMAP similar genes for JUNB using alignment to 3 protein entries: JUNB_HUMAN (see all proteins):

RNASEH2A JUN JUND

JUNB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10405830^1,2	C,	--	12900796(+)	`GGGGCC/TGGCCC`	1	--	us2k¹		0	--	--	--	--
rs189235056^1,2		--	12901302(+)	`TGGGGC/GACAGA`	1	--	us2k¹		0	--	--	--	--
rs181588333^1,2		--	12901318(+)	`CAGATA/GACTAA`	1	--	us2k¹		0	--	--	--	--
rs186524943^1,2		--	12901324(+)	`ACTAAC/GAGGTT`	1	--	us2k¹		0	--	--	--	--
rs16978669^1,2		--	12901468(+)	`CTAACT/ACTCTC`	1	--	us2k¹ trp³		2		MN EA	356
rs182244969^1,2		--	12901488(+)	`GGCTAC/GCAGAT`	1	--	us2k¹		0	--	--	--	--
rs113829655^1,2	C,	--	12901498(+)	`GACCCCAATTT CTGG/-CAGTG`	1	--	us2k¹		1		CSA	2
rs17881432^1,2	F	--	12901500(+)	`CCCCA-/ATTT CTGGCAGTGGT`	1	--	us2k¹		1		NS	168
rs17878468^1,2	C,F,H,	--	12901511(+)	`CCCCAA/GTTTCT`	1	--	us2k¹		10		NS NA WA CSA	1180
rs77647455^1,2	F,	--	12901629(+)	`CGCTTA/GCGGGA`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for JUNB (12902310 - 12904125 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JUNB
1 CNV: 4400

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing JUNB:

Oncogenes & Tumor Suppressor Genes 384HC

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JUNB

DNA2.0 Custom Variant and Variant Library Synthesis for JUNB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

JUNB for disorders           About GeneDecksing

OMIM gene information: 165161    OMIM disorders: --

20/46 diseases for JUNB (see all 46):    About MalaCards

splenic marginal zone lymphoma anaplastic large cell lymphoma human t-cell leukemia virus type 1 lymphomatoid papulosis

myeloproliferative disorder b-cell lymphomas myeloid leukemia rheumatoid arthritis

chronic myeloid leukemia cutaneous t cell lymphoma leukemia familial breast cancer

pheochromocytoma hodgkin's lymphoma hepatocellular carcinoma cervical cancer

t-cell leukemia breast cancer osteoarthritis thymoma

10/39 Novoseek disease relationships for JUNB gene (see all 39) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia t-cell	51.3	2	12937177 (1), 17306025 (1)
myeloid leukemia	48.9	7	2122229 (2), 1373742 (2), 2007095 (1), 16618766 (1) (see all 5)
anaplastic large cell lymphoma	44.9	9	15920551 (3), 17965727 (2), 16140928 (2), 15377339 (1)
hodgkin disease	33.3	10	15920551 (2), 17965727 (2), 12145210 (2), 16140928 (2) (see all 6)
myeloproliferative disorders	29	4	15507213 (2), 16024645 (1), 12506033 (1)
tumors	26.6	30	17009623 (3), 8649827 (2), 10502734 (2), 1404666 (2) (see all 19)
myeloid leukemia chronic	26.3	6	12506033 (2), 10714213 (1), 15507213 (1), 20030915 (1) (see all 5)
blast crisis	24.7	2	18346528 (1), 12506033 (1)
necrosis	23.1	5	9528756 (1), 1404666 (1), 8631909 (1)
neoplastic transformation	22.1	2	10874008 (1), 12506033 (1)

Human Genome Epidemiology (HuGE) Navigator: JUNB (3 documents)

Export disorders for JUNB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for JUNB gene, integrated from 9 sources (see all 431):
(articles sorted by number of sources associating them with JUNB)

Utopia: connect your pdf to the dynamic
world of online information

jun-B inhibits and c-fos stimulates the transforming and trans- activating activities of c-jun. (PubMed id 2513129)^{1, 2, 3} Schuette J.... Minna J. (1989)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complex genetic organization of junB: multiple blocks of flanking evolutionarily conserved sequence at the murine and human junB loci. (PubMed id 8530030)^{1, 2} Phinney D.G.... Ryder K. (1995)
Isolation of human cDNA clones of jun-related genes, jun-B and jun- D. (PubMed id 2112242)^{1, 2} Nomura N.... Ishizaki R. (1990)
JunB inhibits proliferation and transformation in B-lymphoid cells. (PubMed id 12907453)^{1, 9} Szremska A.P....Sexl V. (2003)
[Methylation status of JunB and CDH13 gene promoter i n CD34(+)CD38(-) chronic myelogenous leukemia cells] (PubMed id 20030915)^{1, 9} Wang X.J....Huang S.A. (2009)
Reciprocal effects of C/EBPalpha and PKCdelta on JunB expression and monocytic differentiation depend upon the C/EBPalpha basic region. (PubMed id 12522006)^{1, 9} Liu H....Friedman A.D. (2003)
JunB gene expression is inactivated by methylation in chronic myeloid leukemia. (PubMed id 12506033)^{1, 9} Yang M.Y....Lin S.F. (2003)
Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PubMed id 19666408)^{1, 9} Guo C....Yang X. (2009)
Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. (PubMed id 20132737)^{1, 9} Son Y.O....Lee J.C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3726	HGNC: 6205	AceView: JUNB	Ensembl:ENSG00000171223	euGenes: HUgn3726
ECgene: JUNB	Kegg: 3726	H-InvDB: JUNB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for JUNB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for JUNB	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/junb/

Intellectual Property for JUNB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for JUNB gene:
Search GeneIP for patents involving JUNB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of JUNB

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for JUNB (JunB)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for JUNB		OriGene shRNA RFP for JUNB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUNB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JUNB
	OriGene Protein Over-expression Lysate for JUNB		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for JUNB		OriGene 3'-UTR Clone for JUNB
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JUNB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for JUNB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for JUNB		OriGene Custom Protein Services for JUNB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JUNB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JUNB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUNB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUNB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUNB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUNB

	GenScript Custom Purified and Recombinant Proteins Services for JUNB		GenScript cDNA clones with any tag delivered in your preferred vector for JUNB
	GenScript Custom Assay Services for JUNB		GenScript Superior Antibodies for JUNB
	GenScript Custom overexpressing Cell Line Services for JUNB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for JUNB

	Regulatory tfbs in JUNB promoter
	Search Chromatin IP Primers for JUNB
	RT² qPCR Primer Assay in human, mouse, rat JUNB
	GNC Network for JUNB
	SABiosciences PCR Arrays including human, mouse, rat JUNB

Search Tocris compounds for JUNB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	JUNB antibodies
	JUNB proteins
	JUNB lysates

	Antibodies for JUNB
	See all of Abcam's Antibodies, Kits and Proteins for JUNB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

JUNB Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for JUNB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for JUNB

	SwitchGear 3'UTR luciferase reporter plasmids for JUNB
	SwitchGear Promoter luciferase reporter plasmids for JUNB

ThermoFisher Antibody for JUNB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUNB

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes JUNB gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

JUNB Gene

jun B proto-oncogene

Aliases
for JUNB gene

Summaries
for JUNB gene

Genomic Views
for JUNB gene

Proteins
for JUNB gene

Protein Domains /
Families
for JUNB gene

Function
for JUNB gene

Pathways & Interactions
for JUNB gene

Drugs & Compounds
for JUNB gene

Transcripts
for JUNB gene

Expression
for JUNB gene

Orthologs
for JUNB gene

Paralogs
for JUNB gene

Genomic Variants
for JUNB gene

Disorders / Diseases
for JUNB gene

Publications
for JUNB gene

External Searches for JUNB gene

Genome Databases showing JUNB gene

Other Databases showing JUNB gene

Specialized Databases showing JUNB gene

Intellectual Property
for JUNB gene

Products
for JUNB gene

View Random Gene

Gastric Cancer
Myeloid Leukemia
Melanoma
Leukemia T-Cell
Retinoblastoma
Glioma
Lymphoma T-Cell
Carcinoma
Hodgkin Disease
Osteoarthritis
Leukemia
Myeloid Leukemia Chronic
Ischemia
Osteosarcoma
Breast Cancer
anaplastic large cell lymphoma
Blast Crisis
HEPATOCELLULAR CARCINOMA
Adenocarcinoma
metastatic melanoma
Cancer
premalignant
Lymphoma
Myeloproliferative Disorders
Response Acute Phase
Lymphoma B-Cell
Inflammation
Colorectal Tumors
Psoriasis
Cervical Cancer
Hypertrophy
Rheumatoid Arthritis
Tumors
Metastasis
Pheochromocytoma
Lymphoma Non-Hodgkins
Necrosis
leukemogenesis
neoplastic transformation

Advanced Search

Export list of displayed genes

JUNB Gene

jun B proto-oncogene

Aliasesfor JUNB gene

Summariesfor JUNB gene

Genomic Viewsfor JUNB gene

Proteinsfor JUNB gene

Protein Domains /Familiesfor JUNB gene

Functionfor JUNB gene

Pathways & Interactionsfor JUNB gene

Drugs & Compoundsfor JUNB gene

Transcriptsfor JUNB gene

Expression for JUNB gene

Orthologsfor JUNB gene

Paralogsfor JUNB gene

Genomic Variantsfor JUNB gene

Disorders / Diseasesfor JUNB gene

Publicationsfor JUNB gene

External Searches for JUNB gene

Genome Databases showing JUNB gene

Other Databases showing JUNB gene

Specialized Databases showing JUNB gene

Intellectual Propertyfor JUNB gene

Productsfor JUNB gene

View Random Gene

Aliases
for JUNB gene

Summaries
for JUNB gene

Genomic Views
for JUNB gene

Proteins
for JUNB gene

Protein Domains /
Families
for JUNB gene

Function
for JUNB gene

Pathways & Interactions
for JUNB gene

Drugs & Compounds
for JUNB gene

Transcripts
for JUNB gene

Expression
for JUNB gene

Orthologs
for JUNB gene

Paralogs
for JUNB gene

Genomic Variants
for JUNB gene

Disorders / Diseases
for JUNB gene

Publications
for JUNB gene

Intellectual Property
for JUNB gene

Products
for JUNB gene