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Aliases for JUNB Gene

Aliases for JUNB Gene

  • Jun B Proto-Oncogene 2 3 5
  • Activator Protein 1 3
  • AP-1 3

External Ids for JUNB Gene

Previous GeneCards Identifiers for JUNB Gene

  • GC19P013033
  • GC19P013125
  • GC19P012747
  • GC19P012763
  • GC19P012902
  • GC19P012474

Summaries for JUNB Gene

GeneCards Summary for JUNB Gene

JUNB (Jun B Proto-Oncogene) is a Protein Coding gene. Diseases associated with JUNB include anaplastic large cell lymphoma and fumarate hydratase deficiency. Among its related pathways are Osteoclast differentiation and TNF signaling pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot for JUNB Gene

  • Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3.

Gene Wiki entry for JUNB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUNB Gene

Genomics for JUNB Gene

Regulatory Elements for JUNB Gene

Enhancers for JUNB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JUNB on UCSC Golden Path with GeneCards custom track

Promoters for JUNB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JUNB on UCSC Golden Path with GeneCards custom track

Genomic Location for JUNB Gene

Chromosome:
19
Start:
12,791,496 bp from pter
End:
12,793,315 bp from pter
Size:
1,820 bases
Orientation:
Plus strand

Genomic View for JUNB Gene

Genes around JUNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUNB Gene

Proteins for JUNB Gene

  • Protein details for JUNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17275-JUNB_HUMAN
    Recommended name:
    Transcription factor jun-B
    Protein Accession:
    P17275
    Secondary Accessions:
    • Q96GH3

    Protein attributes for JUNB Gene

    Size:
    347 amino acids
    Molecular mass:
    35879 Da
    Quaternary structure:
    • Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

neXtProt entry for JUNB Gene

Proteomics data for JUNB Gene at MOPED

Post-translational modifications for JUNB Gene

Other Protein References for JUNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JUNB Gene

Domains & Families for JUNB Gene

Suggested Antigen Peptide Sequences for JUNB Gene

Graphical View of Domain Structure for InterPro Entry

P17275

UniProtKB/Swiss-Prot:

JUNB_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Jun subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUNB: view

Function for JUNB Gene

Molecular function for JUNB Gene

GENATLAS Biochemistry:
jun protooncogene homolog B,ligand induced,immediate (primary) early response gene
UniProtKB/Swiss-Prot Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5-TGA[CG]TCA-3.
UniProtKB/Swiss-Prot Induction:
By growth factors.

Gene Ontology (GO) - Molecular Function for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0005515 protein binding IEA,IPI 16511568
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with JUNB: view
genes like me logo Genes that share phenotypes with JUNB: view

Animal Model Products

Transcription Factor Targets for JUNB Gene

Selected GeneGlobe predicted Target genes for JUNB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for JUNB Gene

Localization for JUNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUNB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUNB Gene COMPARTMENTS Subcellular localization image for JUNB gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for JUNB Gene

Pathways & Interactions for JUNB Gene

genes like me logo Genes that share pathways with JUNB: view

SIGNOR curated interactions for JUNB Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for JUNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0001570 vasculogenesis IEA --
GO:0001649 osteoblast differentiation IEA --
GO:0001701 in utero embryonic development IEA --
GO:0001829 trophectodermal cell differentiation IEA --
genes like me logo Genes that share ontologies with JUNB: view

Drugs & Compounds for JUNB Gene

(35) Drugs for JUNB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(22) Additional Compounds for JUNB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with JUNB: view

Transcripts for JUNB Gene

mRNA/cDNA for JUNB Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(667) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUNB Gene

Jun B proto-oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JUNB Gene

No ASD Table

Relevant External Links for JUNB Gene

GeneLoc Exon Structure for
JUNB
ECgene alternative splicing isoforms for
JUNB

Expression for JUNB Gene

mRNA expression in normal human tissues for JUNB Gene

mRNA differential expression in normal tissues according to GTEx for JUNB Gene

This gene is overexpressed in Fallopian Tube (x4.9).

Protein differential expression in normal tissues from HIPED for JUNB Gene

This gene is overexpressed in Placenta (19.9), Peripheral blood mononuclear cells (18.5), CD8 Tcells (13.7), and Monocytes (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for JUNB Gene



SOURCE GeneReport for Unigene cluster for JUNB Gene Hs.25292

genes like me logo Genes that share expression patterns with JUNB: view

Protein tissue co-expression partners for JUNB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for JUNB Gene

Orthologs for JUNB Gene

This gene was present in the common ancestor of animals.

Orthologs for JUNB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia JUNB 35
  • 92.7 (n)
  • 96.54 (a)
JUNB 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JUNB 35
  • 92.89 (n)
  • 97.12 (a)
JUNB 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Junb 35
  • 88.95 (n)
  • 93.6 (a)
Junb 16
Junb 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia JUNB 35
  • 99.9 (n)
  • 99.71 (a)
JUNB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Junb 35
  • 88.47 (n)
  • 93.9 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia JUNB 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JUNB 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia junb 35
  • 60 (n)
  • 59.66 (a)
zebrafish
(Danio rerio)
Actinopterygii junba 36
  • 58 (a)
OneToMany
junbb 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Jra 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for JUNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUNB Gene

ENSEMBL:
Gene Tree for JUNB (if available)
TreeFam:
Gene Tree for JUNB (if available)

Paralogs for JUNB Gene

Paralogs for JUNB Gene

(3) SIMAP similar genes for JUNB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JUNB: view

Variants for JUNB Gene

Sequence variations from dbSNP and Humsavar for JUNB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17880705 - 12,792,459(+) CGCAG(C/G)TGGGC reference, missense
rs16978669 -- 12,790,654(+) CTAAC(A/T)CTCTC upstream-variant-2KB
rs17878468 -- 12,790,697(+) CCCCA(A/G)TTTCT upstream-variant-2KB
rs17880845 -- 12,790,263(+) GGGCG(A/G)GGCGC upstream-variant-2KB
rs17881347 -- 12,792,950(+) CGGCC(C/G)TCCTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JUNB Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294
nsv911079 CNV Loss 21882294
dgv3734n71 CNV Loss 21882294

Variation tolerance for JUNB Gene

Gene Damage Index Score: 0.72; 15.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JUNB Gene

HapMap Linkage Disequilibrium report
JUNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUNB Gene

Disorders for JUNB Gene

MalaCards: The human disease database

(3) MalaCards diseases for JUNB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
anaplastic large cell lymphoma
  • alcl
fumarate hydratase deficiency
  • fumarase deficiency
lymphomatoid papulosis
  • lyp
- elite association - COSMIC cancer census association via MalaCards
Search JUNB in MalaCards View complete list of genes associated with diseases

Relevant External Links for JUNB

Genetic Association Database (GAD)
JUNB
Human Genome Epidemiology (HuGE) Navigator
JUNB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JUNB
genes like me logo Genes that share disorders with JUNB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUNB Gene

Publications for JUNB Gene

  1. jun-B inhibits and c-fos stimulates the transforming and trans- activating activities of c-jun. (PMID: 2513129) Schuette J. … Minna J. (Cell 1989) 2 3 4 67
  2. Over-expression of JunB inhibits mitochondrial stress and cytotoxicity in human lymphoma cells exposed to chronic oxidative stress. (PMID: 20132737) Son Y.O. … Lee J.C. (BMB Rep 2010) 3 23
  3. Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma. (PMID: 19666408) Guo C. … Yang X. (HBPD INT 2009) 3 23
  4. [Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells]. (PMID: 20030915) Wang X.J. … Huang S.A. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 23
  5. Hypomethylation of CD30 CpG islands with aberrant JunB expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma. (PMID: 17965727) Watanabe M. … Horie R. (Lab. Invest. 2008) 3 23

Products for JUNB Gene

Sources for JUNB Gene

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