Aliases for JUN Gene
External Ids for JUN Gene
Previous GeneCards Identifiers for JUN Gene
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]
GeneCards Summary for JUN Gene
JUN (Jun Proto-Oncogene) is a Protein Coding gene. Diseases associated with JUN include hemorrhagic cystitis and sarcoma. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity. An important paralog of this gene is JUNB.
UniProtKB/Swiss-Prot for JUN Gene
Transcription factor that recognizes and binds to the enhancer heptamer motif 5-TGA[CG]TCA-3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.