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Aliases for JUN Gene

Aliases for JUN Gene

  • Jun Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • V-Jun Avian Sarcoma Virus 17 Oncogene Homolog 2 3 4
  • Proto-Oncogene C-Jun 3 4
  • Activator Protein 1 3 4
  • Jun Oncogene 2 3
  • P39 3 4
  • AP1 3 4
  • V-Jun Sarcoma Virus 17 Oncogene Homolog 3
  • Jun Activation Domain Binding Protein 3
  • Enhancer-Binding Protein AP1 3
  • Transcription Factor AP-1 3
  • C-Jun 3
  • AP-1 3

External Ids for JUN Gene

Previous GeneCards Identifiers for JUN Gene

  • GC01M059163
  • GC01M058161
  • GC01M058604
  • GC01M058616
  • GC01M058958
  • GC01M057356
  • GC01M059246

Summaries for JUN Gene

Entrez Gene Summary for JUN Gene

  • This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

CIViC summary for JUN Gene

GeneCards Summary for JUN Gene

JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Sarcoma and Pertussis. Among its related pathways are Development EGFR signaling via small GTPases and RANK Signaling in Osteoclasts. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot for JUN Gene

  • Transcription factor that recognizes and binds to the enhancer heptamer motif 5-TGA[CG]TCA-3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Gene Wiki entry for JUN Gene

Additional gene information for JUN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUN Gene

Genomics for JUN Gene

GeneHancer (GH) Regulatory Elements for JUN Gene

Promoters and enhancers for JUN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I058779 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.2 1166 8 FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 LINC01135 JUN MYSM1 FGGY LOC105378751
GH01I058812 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 27 -32.0 -31982 7.8 FOXA2 ARID4B SIN3A FEZF1 DMAP1 POLR2B ZNF766 ZNF207 ZNF143 FOS PIR37218 JUN MYSM1 LINC01135 FGGY ENSG00000272226 LOC101926907 ENSG00000231740
GH01I058894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -115.8 -115805 10.7 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 SP3 NFYC PPARGC1A MEF2D LINC01135 MYSM1 JUN LOC105378753 FGGY PIR58695
GH01I058925 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.4 -145.6 -145606 8.3 PKNOX1 ARNT SIN3A TCF12 FOS DEK REST SMARCB1 SREBF1 MAFF LINC01135 JUN FGGY LOC105378753 TACSTD2 LINC01358
GH01I058880 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -100.1 -100110 7.1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 NFYC MEF2D LINC01135 FGGY JUN LOC105378753 PIR58695 GC01M058846
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around JUN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JUN gene promoter:

Genomic Locations for JUN Gene

Genomic Locations for JUN Gene
chr1:58,780,788-58,784,327
(GRCh38/hg38)
Size:
3,540 bases
Orientation:
Minus strand
chr1:59,246,463-59,249,785
(GRCh37/hg19)

Genomic View for JUN Gene

Genes around JUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUN Gene

Proteins for JUN Gene

  • Protein details for JUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05412-JUN_HUMAN
    Recommended name:
    Transcription factor AP-1
    Protein Accession:
    P05412
    Secondary Accessions:
    • Q6FHM7
    • Q96G93

    Protein attributes for JUN Gene

    Size:
    331 amino acids
    Molecular mass:
    35676 Da
    Quaternary structure:
    • Heterodimer with either FOS or BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527). Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478). Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781). Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876). Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748). Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463). Found in a complex with PRR7 and FBXW7 (PubMed:27458189). Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189).

    Three dimensional structures from OCA and Proteopedia for JUN Gene

neXtProt entry for JUN Gene

Post-translational modifications for JUN Gene

  • Acetylated at Lys-271 by EP300.
  • Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
  • Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463).

Other Protein References for JUN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for JUN (Jun)
  • Abcam antibodies for JUN

No data available for DME Specific Peptides for JUN Gene

Domains & Families for JUN Gene

Gene Families for JUN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for JUN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05412

UniProtKB/Swiss-Prot:

JUN_HUMAN :
  • Belongs to the bZIP family. Jun subfamily.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUN: view

Function for JUN Gene

Molecular function for JUN Gene

GENATLAS Biochemistry:
avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting with MYC to regulate AP1 genes
UniProtKB/Swiss-Prot Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5-TGA[CG]TCA-3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Phenotypes From GWAS Catalog for JUN Gene

Gene Ontology (GO) - Molecular Function for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19861239
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IC 21113145
GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP 19962668
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with JUN: view
genes like me logo Genes that share phenotypes with JUN: view

Animal Models for JUN Gene

MGI Knock Outs for JUN:

Transcription Factor Targets for JUN Gene

Selected GeneGlobe predicted Target genes for JUN
Targeted motifs for JUN Gene
HOMER Transcription Factor Regulatory Elements motif JUN
  • Consensus sequence: GATGACTCATCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Clone Products

  • Addgene plasmids for JUN

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUN Gene

Localization for JUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JUN gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 3
plasma membrane 2
cytoskeleton 2
peroxisome 2
endoplasmic reticulum 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome TAS 10918580
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA 21113145
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with JUN: view

Pathways & Interactions for JUN Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
3 Development HGF signaling pathway
4 TNFR1 Pathway
5 Toll-like receptor signaling pathway
genes like me logo Genes that share pathways with JUN: view

Pathways by source for JUN Gene

SIGNOR curated interactions for JUN Gene

Gene Ontology (GO) - Biological Process for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001774 microglial cell activation IEA --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0001889 liver development IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with JUN: view

Drugs & Compounds for JUN Gene

(74) Drugs for JUN Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma Target, inducer, inhibitor 125
Vinblastine Approved Pharma Target, other/unknown 439
Irbesartan Approved, Investigational Pharma Antagonist, Target, other/unknown Angiotensin II inhibitor 102
Pseudoephedrine Approved Pharma Target 666
Trisenox Approved September 2000 Pharma 0

(62) Additional Compounds for JUN Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 49498
SR 11302
160162-42-5

(1) Tocris Compounds for JUN Gene

Compound Action Cas Number
SR 11302 AP-1 inhibitor; antitumor agent 160162-42-5
genes like me logo Genes that share compounds with JUN: view

Transcripts for JUN Gene

mRNA/cDNA for JUN Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(886) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUN Gene

Jun proto-oncogene:
Representative Sequences:

Clone Products

  • Addgene plasmids for JUN

Alternative Splicing Database (ASD) splice patterns (SP) for JUN Gene

No ASD Table

Relevant External Links for JUN Gene

GeneLoc Exon Structure for
JUN
ECgene alternative splicing isoforms for
JUN

Expression for JUN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JUN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUN Gene

This gene is overexpressed in Bone (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JUN Gene



Protein tissue co-expression partners for JUN Gene

NURSA nuclear receptor signaling pathways regulating expression of JUN Gene:

JUN

SOURCE GeneReport for Unigene cluster for JUN Gene:

Hs.696684

Evidence on tissue expression from TISSUES for JUN Gene

  • Nervous system(4.7)
  • Pancreas(4.5)
  • Lung(4.4)
  • Intestine(4)
  • Muscle(4)
  • Heart(3.7)
  • Kidney(3.6)
  • Liver(3.6)
  • Stomach(3.4)
  • Eye(3.3)
  • Skin(3.3)
  • Adrenal gland(3.1)
  • Blood(3.1)
  • Bone marrow(3)
  • Thyroid gland(2.8)
  • Spleen(2.7)
  • Lymph node(2.5)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with JUN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JUN Gene

Orthologs for JUN Gene

This gene was present in the common ancestor of animals.

Orthologs for JUN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JUN 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia JUN 33 34
  • 94.54 (n)
dog
(Canis familiaris)
Mammalia JUN 33 34
  • 92.85 (n)
mouse
(Mus musculus)
Mammalia Jun 33 16 34
  • 91.54 (n)
rat
(Rattus norvegicus)
Mammalia Jun 33
  • 90.94 (n)
oppossum
(Monodelphis domestica)
Mammalia JUN 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves JUN 33 34
  • 79.14 (n)
lizard
(Anolis carolinensis)
Reptilia JUN 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jun 33
  • 70.65 (n)
zebrafish
(Danio rerio)
Actinopterygii jun 33 34
  • 74.57 (n)
wufj36h07 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006386 33
  • 60.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta Jra 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3347 33
Species where no ortholog for JUN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUN Gene

ENSEMBL:
Gene Tree for JUN (if available)
TreeFam:
Gene Tree for JUN (if available)

Paralogs for JUN Gene

Paralogs for JUN Gene

(2) SIMAP similar genes for JUN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JUN: view

Variants for JUN Gene

Sequence variations from dbSNP and Humsavar for JUN Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs377289876 not-provided, not provided 58,782,413(-) G/C coding_sequence_variant, missense_variant
rs1000134509 -- 58,784,735(-) C/T upstream_transcript_variant
rs1001669638 -- 58,786,110(-) T/A upstream_transcript_variant
rs1002236220 -- 58,781,981(-) T/C 3_prime_UTR_variant
rs1002522831 -- 58,783,476(-) C/G 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for JUN Gene

Variant ID Type Subtype PubMed ID
esv26947 CNV loss 19812545
nsv546315 CNV loss 21841781

Variation tolerance for JUN Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JUN Gene

Human Gene Mutation Database (HGMD)
JUN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUN Gene

Disorders for JUN Gene

MalaCards: The human disease database

(50) MalaCards diseases for JUN Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sarcoma
  • connective and soft tissue neoplasm
pertussis
  • bordetella infection
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
aging
status epilepticus
  • gcse
- elite association - COSMIC cancer census association via MalaCards
Search JUN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for JUN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with JUN: view