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JUN Gene

protein-coding   GIFtS: 67

GC01M059163
jun oncogene
(Previous names: v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma virus 17 oncogene homolog (avian) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for JUN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

  User Feedback
Aliases & Descriptions
jun oncogene1 2     p392 3
V-jun avian sarcoma virus 17 oncogene homolog1 2 3     v-jun sarcoma virus 17 oncogene homolog (avian)1
AP-11 2     Jun activation domain binding protein2
c-Jun1 2     transcription factor AP-12
Proto-oncogene c-Jun2 3     enhancer-binding protein AP12
Activator protein 12 3     v-jun sarcoma virus 17 oncogene homolog2
AP12 3     

External Ids:    HGNC: 62041   Entrez Gene: 37252   Ensembl: ENSG000001776067   UniProtKB: P054123   

Search outside databases for aliases for JUN gene

Previous GC identifers: GC01M058161 GC01M058604 GC01M058616 GC01M058958

Summaries
for JUN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for JUN:
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to
the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This
gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in
human malignancies. (provided by RefSeq)

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412
Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'

Gene Wiki entry for JUN (C-jun)

Genomic Views
for JUN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the JUN gene upstream (promoter) region "":
NF-kappaB1   NF-kappaB   PPAR-gamma2   PPAR-gamma1   GCNF-1   GCNF-2   MEF-2A   deltaCREB   CREB   GATA-3   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for JUN:  ""
MePH01101-2A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32-p31

JUN Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M059163:  view genomic region     (about GC identifiers)

Start:
 59,246,463 bp from pter
End:
 59,249,785 bp from pter
Size:
 3,323 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for JUN gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

  User Feedback		 UniProtKB/Swiss-Prot: JUN_HUMAN, P05412 (See protein sequence)
Recommended Name: Transcription factor AP-1  
Size: 331 amino acids; 35676 Da
Subunit: Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4
heterodimers. Interacts with MYBBP1A, SP1, SPIB and TCF20. Interacts with COPS5; indirectly leading to its
phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA
Subcellular location: Nucleus
PDB structures from "" and Proteopedia "" :
1A02 (3D) ""    1FOS (3D) ""    1JNM (3D) ""    1JUN (3D) ""    1S9K (3D) ""    1T2K (3D) ""    
Secondary accessions: Q96G93

Post-translational modifications:

  • Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002219.1  

    ENSEMBL proteins: 
    ENSP00000360266 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant JUN Protein
    ""Sigma-Aldrich Proteins and CompoZr ZFN and Flag-tag genes for JUN
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for JUN
    ""HuPro® and/or Recombinant Proteins from Abnova for JUN ""
    "" Origene Purified Recombinant Human Protein: JUN
    ""Novus Biologicals Proteins for JUN  ""
    Novus Biologicals Lysates for JUN
    ""Browse Sino Biological Recombinant Proteins  ""

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228 nuclear chromosome TAS10918580
    GO:0000790 nuclear chromatin IEA--
    GO:0005634 nucleus IEA--
    GO:0005667 transcription factor complex IEA--
    GO:0005829 cytosol EXP9030721
    About this table

    "" JUN for ontologies           About GeneDecksing



    Antibodies for JUN: 
    ""Millipore Mono- and Polyclonal Antibodies for the study of JUN
    ""Sigma-Aldrich Antibody Arrays and Antibodies for JUN
    ""R&D Systems Antibodies for JUN (c-Jun)
    ""Cell Signaling Technology (CST) Antibodies for JUN (JUN, c-Jun)
    ""Monoclonal and Polyclonal Antibodies from Abnova (JUN)
    "" Origene Antibodies (see all 13): JUN ""
    ""Novus Biologicals Antibodies for JUN
    ""Epitomics antibodies for JUN

    Assays for JUN: 
    ""Millipore Kits and Assays for the Analysis of JUN
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Cell Signaling Technology (CST) Sandwich ELISA Kits for JUN (JUN, c-Jun)
    ""Browse Enzo Life Sciences for kits & assays

    Protein Domains/
    Families
    for JUN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

      User Feedback
    "" JUN for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6 ):
     IPR004827 TF_bZIP
     IPR008917 Euk_TF_DNA_bd
     IPR011616 bZIP_1
     IPR002112 Leuzip_Jun
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P05412

    ProtoNet protein and cluster: P05412

    3 Blocks protein families:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUN_HUMAN, P05412
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP domain

    Gene Function
    for JUN gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of JUN Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (JUN)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: JUN
    Origene shRNA RFP: JUN
    Origene basic RS shRNA: JUN

    ""Applied Biosystems Silencer® siRNAs for JUN
    ""Sigma-Aldrich siRNA for JUN
    Sigma-Aldrich shRNA Panels and shRNA for JUN
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: JUN
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: JUN
    Origene untagged cDNA clones in CMV expression vector: JUN
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: JUN_HUMAN, P05412
    Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'

    Genatlas biochemistry entry for JUN:
    avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting
    with MYC to regulate AP1 genes

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS2825349
    GO:0003690 double-stranded DNA binding IEA--
    GO:0003700 transcription factor activity IDA9732876
    GO:0003702 RNA polymerase II transcription factor activity IEA--
    GO:0005100 Rho GTPase activator activity IDA11804590
    About this table

    "" JUN for ontologies           About GeneDecksing

    Animal Models: 15/18 MGI mutant phenotypes (inferred from 10 alleles"") (MGI details for Jun) (see all 18 ):

    behavior/neurologicalcardiovascular systemcellularembryogenesisendocrine/exocrine gland
    growth/sizehematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/agingliver/biliary systemnervous systemno phenotypic analysis

    "" JUN for phenotypes           About GeneDecksing

    Pathways & Interactions
    for JUN gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" JUN for pathways           About GeneDecksing

    5/51 "" Millipore Pathways for JUN (see all 51 )
      ""  Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Immune response MIF-mediated glucocorticoid regulation
    Immune response MIF in innate immunity response
    Immune response IL-1 signaling pathway

    5/75 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  JUN  (Your Favorite Gene powered by Ingenuity) (see all 75 )
      ""  Ceramide Signaling
    Hypoxia Signaling in the Cardiovascular System
    PPAR Signaling
    GNRH Signaling
    Corticotropin Releasing Hormone Signaling

    5/99 "" GeneAssist Pathways for JUN (see all 99 )
      ""  CCKBR-Gastrin Stimulated Signaling
    Prolactin Signaling
    ITK and TCR Signaling
    TNFR2 Pathway
    TRAF Pathway

    3 "" Cell Signaling Technology (CST) Pathways for JUN: 
      ""  SAPK/JNK Signaling Cascades
    T Cell Receptor Signaling
    B Cell Receptor Signaling

    5/14 "" Kegg Pathways  (Kegg details for JUN) (see all 14 ):
      ""  hsa04010 MAPK signaling pathway
    hsa04012 ErbB signaling pathway
    hsa04310 Wnt signaling pathway
    hsa04510 Focal adhesion
    hsa04620 Toll-like receptor signaling pathway

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JUN

    5/20 Interacting proteins for JUN (P054121, 2) via UniProtKB, MINT, and/or STRING (see all 20 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK8P459831, 2EBI-852823,EBI-286483 MINT-7148314 EBI-852823,EBI-286483 MINT-7148314
    VRK1Q999861EBI-852823,EBI-1769146
    EDF1O60869-11EBI-852823,EBI-781310
    DDX21Q9NR302MINT-14075 MINT-14076 MINT-14077
    ATF2P153362MINT-6699748 MINT-6628041
    About this table

    5/30 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 30 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525 angiogenesis IEA--
    GO:0001836 release of cytochrome c from mitochondria IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007179 transforming growth factor beta receptor signaling pathway IDA9732876
    GO:0007184 SMAD protein nuclear translocation IDA9732876
    About this table

    "" JUN for ontologies           About GeneDecksing


    Drugs & Compounds
    for JUN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" JUN for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for JUN
    ""Sigma-Aldrich Small Molecules for JUN:
    Small Molecule - Inhibitor

    "" Browse Tocris compounds for JUN
    10/1361 ""Novoseek chemical compound relationships for JUN gene (see all 1361 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    phorbol 12-myristate 13-acetate 100.00 724 11358830 (11), 2105946 (10), 8170999 (6), 1939341 (6) (see all 100)
    sp600125 100.00 155 12031798 (4), 19405983 (2), 18487435 (2), 18251700 (2) (see all 100)
    curcumin 100.00 227 16157375 (6), 16053715 (5), 9439980 (4), 7955078 (4) (see all 100)
    phorbol 54.98 85 1901643 (3), 1850629 (3), 9037208 (2), 8892460 (2) (see all 74)
    leucine 50.60 264 2509385 (5), 15087451 (5), 8112339 (4), 2501150 (4) (see all 100)
    pd 98059 49.79 102 15627897 (2), 15240007 (2), 12592382 (2), 12016209 (2) (see all 96)
    okadaic acid 44.32 114 9022811 (8), 1851743 (8), 1419903 (6), 12036911 (6) (see all 53)
    sb203580 28.89 62 15240007 (2), 11367542 (2), 11053056 (2), 9973495 (1) (see all 59)
    retinoic acid 22.30 326 9377582 (8), 12494454 (7), 10329043 (7), 9139741 (6) (see all 100)
    15-deoxy-delta-12,14-prostaglandin j2 18.68 41 14532268 (7), 15289320 (4), 14693716 (3), 12774315 (3) (see all 23)
    About this table

    2 PharmGKB drug compound relationships for JUN gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    mercaptopurinePD  FA  GN  12704389
    methotrexatePD  FA  GN  12704389
    About this table


    Transcripts
    for JUN gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Millipore RNAi Products for the Analysis of JUN Gene knock-down
    ""Abnova Chimera RNAi Products for Gene knock-down (JUN)
    ""Applied Biosystems Silencer® siRNAs:  NM_002228  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: JUN
    Origene shRNA RFP: JUN
    Origene basic RS shRNA: JUN

    ""Sigma-Aldrich siRNA for JUN
    Sigma-Aldrich shRNA Panels and shRNA for JUN
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""10 SABiosciences microRNAs that regulate JUN: ""
    hsa-miR-495 hsa-miR-92a hsa-miR-25 hsa-miR-139-5p hsa-miR-200a hsa-miR-32 hsa-miR-30a* hsa-miR-141 hsa-miR-362-5p hsa-miR-30e*
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_002228  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: JUN
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: JUN
    Origene untagged cDNA clones in CMV expression vector: JUN
    Primers:"" Origene genome-wide validated SYBR primer pairs: JUN
    ""SABiosciences RT2 qPCR Primer Assay for JUN: PPH00095A ""

    REFSEQ mRNAs for JUN gene: 

    NM_002228.3  

    Additional cDNA sequence: 

    AK307137.1 BC002646.2 BC006175.1 BC009874.2 BC068522.1 BT019759.1 CR541724.1 CR541752.1 

    22 DOTS entries:

    DT.97762702  DT.100044313  DT.121359986  DT.121359920  DT.450792  DT.100675414  DT.100863059  DT.100675418 
    DT.100851939  DT.121359919  DT.121359948  DT.92473418  DT.95264854  DT.95107720  DT.121359935  DT.95132043 
    DT.100804761  DT.91897383  DT.92473595  DT.100675423  DT.121359950  DT.91843574 

    24/886 AceView cDNA sequences (see all 886 ):

    CA952681 BU617685 CA395719 AW071971 AW007689 BM747239 BE890895 AA476238 
    AI077423 BQ269083 AA029968 BM750603 AA992452 AI262566 N70643 H45005 
    AI340023 BM767296 AI697220 BQ186100 BM767396 BM127784 CB155645 CA865626 

    "" highest scoring ESTs for JUN:

    AW005304 AA027941 AA040560 AA159143 AA179925 AA281805 AA351935 AA362757 AA423803 AA436799 

    Unigene Cluster for JUN:

    Jun oncogene
    Hs.723911  [show with all ESTs]
    Unigene Representative Sequence: NM_002228


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000371222  

    Expression
    for JUN gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

      User Feedback

    JUN expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for JUN

    1""  / 2""  / 3""

    9 probe-sets matching JUN gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    89913_s_at2, 3 U95-D 1 0.75 1.00 0.95 1.10 AW005304 1.00 1.00 1.00 1
    32583_at*2, 3 U95-A 1 -- -- 0.96 1.03 J04111 0.20 1.00 0.72 1
    1895_at*2, 3 U95-A 1 -- -- 0.94 0.87 J04111 0.20 1.00 0.72 1
    201465_s_at2, 3 U133-A 1 0.82 1.00 -- -- BC002646 0.80 1.00 0.91 1
    201466_s_at2, 3 U133-A 1 0.36 1.00 -- -- NM_002228 0.60 1.00 0.82 1
    201464_x_at2, 3 U133-A 1 0.27 1.00 -- -- BG491844 0.40 1.00 0.76 1
    201465_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    201466_s_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    201464_x_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    "" JUN for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCTTTGTAAG

    SOURCE GeneReport for Unigene cluster: Hs.723911

    Expression variation in blood from EXPOLDB for JUN

    Primers:"" Origene genome-wide validated SYBR primer pairs: JUN ""
    ""SABiosciences RT2 qPCR Primer Assay for JUN: PPH00095A ""

    Orthologs
    for JUN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

      User Feedback
    Orthologs for JUN gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 JUN1   -- jun oncogene 93.15(n)
    95.64(a)    		 609429  XM_860621.1  XP_865714.1 
    chimpanzee
    (Pan troglodytes)    		 JUN1   -- jun oncogene 99.8(n)
    100(a)    		 456893  XM_513442.2  XP_513442.2 
    cow
    (Bos taurus)    		 JUN1   -- jun oncogene 94.76(n)
    98.19(a)    		 280831  XM_001249361.1  XP_001249362.1 
    rat
    (Rattus norvegicus)    		 Jun1   -- Jun oncogene 91.14(n)
    96.68(a)    		 24516  NM_021835.3  NP_068607.1 
    mouse
    (Mus musculus)    		 Jun1, 5 4 (44.60 cM)5
    		 Jun oncogene1, 5 91.74(n)1
    97.28(a)1    		 164761  NM_010591.11  NP_034721.11 
     AK1320195  AK1337225  (see all 21)
    About this table        Species with no ortholog for JUN

    ENSEMBL Gene Tree for JUN

    Paralogs
    for JUN gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      User Feedback
    Paralogs for JUN gene
    JUND2  JUNB2  

    "" JUN for paralogs           About GeneDecksing


    Genomic Variants
    for JUN gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

      User Feedback
    10/15 NCBI SNPs in JUN are shown (see all 15 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 35)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs27605011,2
    		C,F,O,A,H57361421(+) CAGGCT/GACCAC 1 -- ng51""13Minor allele frequency- G:0.35NS EA NA 1138""
    --
    rs46469991,2
    		C,F,A,H57360776(-) CGAGAC/TGCAAA 1 -- ng51""14Minor allele frequency- T:0.34NS EA NA MN WA 960""
    --
    rs46470011,2
    		C,F,A,H57360742(-) GGGCCC/GACTCT 1 -- ng51""7Minor allele frequency- G:0.31NS MN EA NA 528""
    ""
    rs46470031,2
    		C,F57360340(-) GGGCGG/AGCCGG 1 -- ng51""1Minor allele frequency- A:0.01NS 166""
    --
    rs46470071,2
    		C,F59249497(-) GCCGCCCCC/-  
                GGGAG     		1 -- ut51""6Minor allele frequency- -:0.03NS MN 570""
    ""
    rs37488141,2
    		C,F59249568(+) GCTCTG/AGGCAG 1 -- ut51 ese3""10Minor allele frequency- A:0.03EA MN NS 2316""
    --
    rs46470001,2
    		C,F57360763(-) TCGGAG/CTGTTC 1 -- ng51""2Minor allele frequency- C:0.10NS WA 218""
    --
    rs46469981,2
    		C,F57361034(-) AACACC/TGGGGT 1 -- ng51""7Minor allele frequency- T:0.06NS 628""
    ""
    rs46470021,2
    		C,F57360417(-) GTTGCG/CAGCGT 1 -- ng51""1Minor allele frequency- C:0.05NS 172""
    --
    rs46470061,2
    		C59249687(-) AGCAGC/AGAGGC 1 -- ut51 ese3""1Minor allele frequency- A:0.01NS 170""
    About this table

    HapMap Linkage Disequilibrium images for JUN (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 1 variation for JUN
         1 CNV: 63848

    Disorders & Mutations
    for JUN gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" JUN for disorders           About GeneDecksing

    OMIM: 165160

    10/757 ""Novoseek disease relationships for JUN gene (see all 757 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dominant-negative mutant 84.83 92 8853897 (3), 8108121 (3), 8455942 (2), 19405983 (2) (see all 81)
    cell transformation 71.77 133 11416221 (5), 8189491 (4), 15886210 (4), 1516834 (4) (see all 90)
    tumor promotion 28.74 52 8631126 (2), 15064752 (2), 12036911 (2), 9472093 (1) (see all 49)
    neoplastic transformation 14.06 45 18757399 (2), 1801783 (2), 1773784 (2), 1543542 (2) (see all 38)
    skin carcinogenesis 10.79 23 9485025 (2), 12616721 (2), 20179211 (1), 19057013 (1) (see all 21)
    oncogenesis 9.23 40 11402340 (3), 1516834 (2), 9819389 (1), 9228025 (1) (see all 37)
    nuclear accumulation 8.14 28 14572605 (2), 11358991 (2), 8344964 (1), 20028981 (1) (see all 26)
    junin 5.66 13 16817762 (6), 1681712 (5), 8623541 (2)
    glucocorticoid resistance 5.39 9 10500841 (4), 16164226 (3), 11237062 (2)
    leukemia myeloid 5.13 34 2122980 (3), 8622627 (2), 8058058 (2), 2174893 (2) (see all 23)
    About this table

    1 PharmGKB disease relationship for JUN gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1PD  FA  GN  12704389
    About this table

    Human Genome Epidemiology Navigator: JUN (114 documents)
    Tumor Gene Database: JUN

    Medical News
    for JUN gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for JUN gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/5762 PubMed articles for JUN gene (see all 5762 ):

    Search for JUN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Genome Databases showing JUN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3725 HGNC: 6204 AceView: JUN Ensembl:ENSG00000177606 euGenes: HUgn3725
    ECgene: JUN Kegg: 3725 H-InvDB: JUN

    Other Databases showing JUN gene

    (According to HUGE)
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    Specialized Databases showing JUN gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for JUN Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/jun/

    Intellectual Property
    for JUN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for JUN gene: ""
    Search GeneIP for patents involving JUN

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    Services
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