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Aliases for JUN Gene

Aliases for JUN Gene

  • Jun Proto-Oncogene, AP-1 Transcription Factor Subunit 2 3 5
  • V-Jun Avian Sarcoma Virus 17 Oncogene Homolog 2 3 4
  • Proto-Oncogene C-Jun 3 4
  • Activator Protein 1 3 4
  • Jun Oncogene 2 3
  • P39 3 4
  • AP1 3 4
  • V-Jun Sarcoma Virus 17 Oncogene Homolog 3
  • Jun Activation Domain Binding Protein 3
  • Enhancer-Binding Protein AP1 3
  • Transcription Factor AP-1 3
  • Jun Proto-Oncogene 3
  • C-Jun 3
  • AP-1 3

External Ids for JUN Gene

Previous GeneCards Identifiers for JUN Gene

  • GC01M059163
  • GC01M058161
  • GC01M058604
  • GC01M058616
  • GC01M058958
  • GC01M057356
  • GC01M059246

Summaries for JUN Gene

Entrez Gene Summary for JUN Gene

  • This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]

GeneCards Summary for JUN Gene

JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Brain Sarcoma and Sarcoma. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and ICos-ICosL Pathway in T-Helper Cell. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot for JUN Gene

  • Transcription factor that recognizes and binds to the enhancer heptamer motif 5-TGA[CG]TCA-3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Gene Wiki entry for JUN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JUN Gene

Genomics for JUN Gene

Regulatory Elements for JUN Gene

Enhancers for JUN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around JUN on UCSC Golden Path with GeneCards custom track

Promoters for JUN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for JUN Gene

Chromosome:
1
Start:
58,780,788 bp from pter
End:
58,784,327 bp from pter
Size:
3,540 bases
Orientation:
Minus strand

Genomic View for JUN Gene

Genes around JUN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JUN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JUN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JUN Gene

Proteins for JUN Gene

  • Protein details for JUN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05412-JUN_HUMAN
    Recommended name:
    Transcription factor AP-1
    Protein Accession:
    P05412
    Secondary Accessions:
    • Q6FHM7
    • Q96G93

    Protein attributes for JUN Gene

    Size:
    331 amino acids
    Molecular mass:
    35676 Da
    Quaternary structure:
    • Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with methylated RNF187. Binds to HIPK3. Interacts (when phosphorylated) with FBXW7 (PubMed:14739463).

    Three dimensional structures from OCA and Proteopedia for JUN Gene

neXtProt entry for JUN Gene

Post-translational modifications for JUN Gene

  • Acetylated at Lys-271 by EP300.
  • Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
  • Ubiquitinated by the SCF(FBXW7), leading to its degradation. Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JUN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for JUN (Jun)

No data available for DME Specific Peptides for JUN Gene

Domains & Families for JUN Gene

Suggested Antigen Peptide Sequences for JUN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05412

UniProtKB/Swiss-Prot:

JUN_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. Jun subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. Jun subfamily.
genes like me logo Genes that share domains with JUN: view

Function for JUN Gene

Molecular function for JUN Gene

GENATLAS Biochemistry:
avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting with MYC to regulate AP1 genes
UniProtKB/Swiss-Prot Function:
Transcription factor that recognizes and binds to the enhancer heptamer motif 5-TGA[CG]TCA-3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

Gene Ontology (GO) - Molecular Function for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 19861239
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IC 21113145
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP 19962668
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
genes like me logo Genes that share ontologies with JUN: view
genes like me logo Genes that share phenotypes with JUN: view

Animal Models for JUN Gene

MGI Knock Outs for JUN:

Animal Model Products

CRISPR Products

Transcription Factor Targets for JUN Gene

Selected GeneGlobe predicted Target genes for JUN
Targeted motifs for JUN Gene
HOMER Transcription Factor Regulatory Elements motif JUN
  • Consensus sequence: GATGACTCATCN Submotif: canonical Cell Type: K562 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for JUN

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for JUN Gene

Localization for JUN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JUN Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JUN Gene COMPARTMENTS Subcellular localization image for JUN gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2
vacuole 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome TAS 10918580
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IEA,IDA 21113145
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA,IBA --
genes like me logo Genes that share ontologies with JUN: view

Pathways & Interactions for JUN Gene

SuperPathways for JUN Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Development HGF signaling pathway
4 Toll-Like receptor Signaling Pathways
5 Toll-like receptor signaling pathway
genes like me logo Genes that share pathways with JUN: view

Pathways by source for JUN Gene

SIGNOR curated interactions for JUN Gene

Gene Ontology (GO) - Biological Process for JUN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001774 microglial cell activation IEA --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0001889 liver development IEA --
GO:0001938 positive regulation of endothelial cell proliferation IEA --
genes like me logo Genes that share ontologies with JUN: view

Drugs & Compounds for JUN Gene

(73) Drugs for JUN Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, inducer 117
Vinblastine Approved Pharma Target, other/unknown 398
Irbesartan Approved, Investigational Pharma Antagonist, Target, other/unknown Angiotensin II inhibitor 99
Pseudoephedrine Approved Pharma Target 569
Trisenox Approved September 2000 Pharma 0

(63) Additional Compounds for JUN Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR 49498
SP 100030
154563-54-9
SR 11302
160162-42-5

(3) Tocris Compounds for JUN Gene

Compound Action Cas Number
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3
SP 100030 NF-kappaB and AP-1 dual inhibitor 154563-54-9
SR 11302 AP-1 inhibitor; antitumor agent 160162-42-5
genes like me logo Genes that share compounds with JUN: view

Transcripts for JUN Gene

mRNA/cDNA for JUN Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(886) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JUN Gene

Jun proto-oncogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for JUN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JUN Gene

No ASD Table

Relevant External Links for JUN Gene

GeneLoc Exon Structure for
JUN
ECgene alternative splicing isoforms for
JUN

Expression for JUN Gene

mRNA expression in normal human tissues for JUN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JUN Gene

This gene is overexpressed in Bone (60.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JUN Gene



Protein tissue co-expression partners for JUN Gene

NURSA nuclear receptor signaling pathways regulating expression of JUN Gene:

JUN

SOURCE GeneReport for Unigene cluster for JUN Gene:

Hs.696684
genes like me logo Genes that share expression patterns with JUN: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JUN Gene

Orthologs for JUN Gene

This gene was present in the common ancestor of animals.

Orthologs for JUN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia JUN 34
  • 94.54 (n)
  • 97.66 (a)
JUN 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JUN 34
  • 92.85 (n)
  • 93.66 (a)
JUN 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jun 34
  • 91.54 (n)
  • 96.98 (a)
Jun 16
Jun 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia JUN 34
  • 99.8 (n)
  • 100 (a)
JUN 35
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jun 34
  • 90.94 (n)
  • 96.37 (a)
oppossum
(Monodelphis domestica)
Mammalia JUN 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves JUN 34
  • 79.14 (n)
  • 86.13 (a)
JUN 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JUN 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jun 34
  • 70.65 (n)
  • 78.71 (a)
zebrafish
(Danio rerio)
Actinopterygii jun 34
  • 74.57 (n)
  • 78.57 (a)
wufj36h07 34
jun 35
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006386 34
  • 60.09 (n)
  • 53.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Jra 35
  • 32 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3347 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for JUN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JUN Gene

ENSEMBL:
Gene Tree for JUN (if available)
TreeFam:
Gene Tree for JUN (if available)

Paralogs for JUN Gene

Paralogs for JUN Gene

(2) SIMAP similar genes for JUN Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JUN: view

Variants for JUN Gene

Sequence variations from dbSNP and Humsavar for JUN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2654 -- 58,781,575(-) CCTGC(C/T)TTCGT utr-variant-3-prime
rs2655 -- 58,781,531(-) TTGAT(G/T)AAAGC utr-variant-3-prime
rs9989 - 58,782,181(-) GTCCA(A/C/T)GGCCA reference, missense
rs11688 -- 58,782,321(-) TCCCA(A/G)GAGCG reference, synonymous-codon
rs12816 -- 58,780,986(+) GGTCA(A/C)AGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JUN Gene

Variant ID Type Subtype PubMed ID
esv26947 CNV loss 19812545
nsv546315 CNV loss 21841781

Variation tolerance for JUN Gene

Residual Variation Intolerance Score: 28.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JUN Gene

Human Gene Mutation Database (HGMD)
JUN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JUN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JUN Gene

Disorders for JUN Gene

MalaCards: The human disease database

(41) MalaCards diseases for JUN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain sarcoma
  • sarcoma of the brain
sarcoma
  • connective and soft tissue neoplasm
pertussis
  • bordetella infection
campylobacteriosis
  • campylobacter infections
esophageal adenosquamous carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search JUN in MalaCards View complete list of genes associated with diseases

Relevant External Links for JUN

Genetic Association Database (GAD)
JUN
Human Genome Epidemiology (HuGE) Navigator
JUN
Tumor Gene Database (TGDB):
JUN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JUN
genes like me logo Genes that share disorders with JUN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JUN Gene

Publications for JUN Gene

  1. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. (PMID: 12547826) Li J. … Liu Y. (J. Biol. Chem. 2003) 3 22 25 65
  2. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PMID: 12087103) Bower K.E. … McGuire K.L. (J. Biol. Chem. 2002) 3 4 22 65
  3. High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. (PMID: 8662824) Junius F.K. … King G.F. (J. Biol. Chem. 1996) 3 4 22 65
  4. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. (PMID: 8464713) Bannister A.J. … Jackson S.P. (Nucleic Acids Res. 1993) 3 4 22 65
  5. Structure and chromosomal localization of the functional intronless human JUN protooncogene. (PMID: 3194415) Hattori K. … Karin M. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4 65

Products for JUN Gene

Sources for JUN Gene

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