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JUN Gene

protein-coding   GIFtS: 71
GCID: GC01M059246

Jun Proto-Oncogene

(Previous names: v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jun Proto-Oncogene1 2     V-Jun Sarcoma Virus 17 Oncogene Homolog (Avian)1
V-Jun Avian Sarcoma Virus 17 Oncogene Homolog1 2 3     AP-12
Jun Oncogene1 2     c-Jun2
Activator Protein 12 3     Enhancer-Binding Protein AP12
Proto-Oncogene C-Jun2 3     Jun Activation Domain Binding Protein2
AP12 3     Transcription Factor AP-12
p392 3     V-Jun Sarcoma Virus 17 Oncogene Homolog2

External Ids:    HGNC: 62041   Entrez Gene: 37252   Ensembl: ENSG000001776067   OMIM: 1651605   UniProtKB: P054123   

Export aliases for JUN gene to outside databases

Previous GC identifers: GC01M059163 GC01M058161 GC01M058604 GC01M058616 GC01M058958 GC01M057356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JUN Gene:
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly
similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene
expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both
translocations and deletions in human malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for JUN Gene:
JUN (jun proto-oncogene) is a protein-coding gene. Diseases associated with JUN include sarcoma, and marek disease. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is JUND.

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412
Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes
activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP
signaling pathway stimulation

Gene Wiki entry for JUN (C-jun) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the JUN gene promoter:
         USF1   STAT5A   GATA-2   HEN1   MZF-1   POU2F1   CP2   USF-1   POU2F1a   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): JUN promoter sequence
   Search Chromatin IP Primers for JUN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JUN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32-p31

JUN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M059246:  view genomic region     (about GC identifiers)

Start:
59,246,463 bp from pter      End:
59,249,785 bp from pter
Size:
3,323 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JUN_HUMAN, P05412 (See protein sequence)
Recommended Name: Transcription factor AP-1  
Size: 331 amino acids; 35676 Da
Subunit: Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7
transactivation activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target
DNA (By similarity). Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20.
Interacts with COPS5; the interaction leads indirectly to its phosphorylation. Component of the
SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site. The SMAD3/SMAD4 heterodimer acts
syngernistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta. Interacts (via
its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is
required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex. Interacts with methylated
RNF187. Binds to HIPK3
6 PDB 3D structures from and Proteopedia for JUN:
1A02 (3D)        1FOS (3D)        1JNM (3D)        1JUN (3D)        1S9K (3D)        1T2K (3D)    
Secondary accessions: Q96G93

Explore the universe of human proteins at neXtProt for JUN: NX_P05412

Explore proteomics data for JUN at MOPED

Post-translational modifications: 

  • Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3.
    Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239.
    Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA.
    Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell
    proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase
    DNA-binding activity1
  • Acetylated at Lys-271 by EP3001
  • Ubiquitination2 at Lys50
  • Modification sites at PhosphoSitePlus

  • See JUN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002219.1  
    ENSEMBL proteins: 
     ENSP00000360266  
    Reactome Protein details: P05412

    JUN Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant JUN Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for JUN
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for JUN
    OriGene Custom MassSpec
    OriGene Custom Protein Services for JUN
    GenScript Custom Purified and Recombinant Proteins Services for JUN
    Novus Biologicals JUN Proteins
    Novus Biologicals JUN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for JUN
    Cloud-Clone Corp. Proteins for JUN

    JUN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of JUN
    R&D Systems Antibodies for JUN (c-Jun)
    Cell Signaling Technology (CST) Antibodies for JUN 
    OriGene Antibodies for JUN
    OriGene Custom Antibody Services for JUN
    Novus Biologicals JUN Antibodies
    Abcam antibodies for JUN
    Cloud-Clone Corp. Antibodies for JUN
    ThermoFisher Antibody for JUN
    LSBio Antibodies in human, mouse, rat for JUN

    JUN Assay Products:

    EMD Millipore Kits and Assays for the Analysis of JUN
    OriGene Custom Assay Services for JUN
    R&D Systems ELISAs for JUN (c-Jun)         (see all)
    GenScript Custom Assay Services for JUN
    Cell Signaling Technology (CST) Sandwich ELISA Kits for JUN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JUN
    Cloud-Clone Corp. CLIAs for JUN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    5 InterPro protein domains:
     IPR002112 Leuzip_Jun
     IPR015558 C_Jun
     IPR004827 bZIP
     IPR008917 TF_DNA-bd
     IPR005643 JNK

    Graphical View of Domain Structure for InterPro Entry P05412

    ProtoNet protein and cluster: P05412

    3 Blocks protein domains:
    IPB002112 Jun transcription factor signature
    IPB005643 Jun-like transcription factor
    IPB011616 bZIP transcription factor


    UniProtKB/Swiss-Prot: JUN_HUMAN, P05412
    Similarity: Belongs to the bZIP family. Jun subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    JUN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JUN_HUMAN, P05412
    Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes
    activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP
    signaling pathway stimulation

         Genatlas biochemistry entry for JUN:
    avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene
    interacting with MYC to regulate AP1 genes

         Gene Ontology (GO): Selected molecular function terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA19861239
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0001102RNA polymerase II activating transcription factor binding IPI19861239
    GO:0001190RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IC19861239
    GO:0003677DNA binding TAS2825349
         
    JUN for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for JUN:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Increased cell death HMECs cel 
     Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Jun) (see all 18):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  nervous system  no phenotypic analysis  normal 

    JUN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for JUN: Juntm1Pa Juntm1Wag

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JUN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JUN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JUN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JUN

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for JUN (see all 2706):
    A2ML1,  A4GALT,  AAA1,  AAAS,  AATF,  ABCA1,  ABCA12,  ABCA9,  ABCB1,  ABCB6

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GATGACTCATCN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target JUN:
    hsa-mir-149-5p (MIRT045693), hsa-mir-101-3p (MIRT027318), hsa-mir-30a-5p (MIRT005128), hsa-mir-16-5p (MIRT000867), hsa-mir-29c-3p (MIRT020367), hsa-mir-93-5p (MIRT048821), hsa-mir-15a-5p (MIRT000868), hsa-mir-155-5p (MIRT006208), hsa-mir-26b-5p (MIRT029641), hsa-mir-342-3p (MIRT043728)

    Block miRNA regulation of human, mouse, rat JUN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JUN (see all 26):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-429 hsa-miR-522 hsa-miR-139-5p hsa-miR-1258 hsa-miR-216b hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidJUN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for JUN
    Predesigned siRNA for gene silencing in human, mouse, rat JUN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JUN

    Clone
    Products:
         
    OriGene clones in human, mouse for JUN (see all 7)
    OriGene ORF clones in mouse, rat for JUN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JUN (NM_002228)
    Sino Biological Human cDNA Clone for JUN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JUN
    Browse ESI BIO Cell Lines and PureStem Progenitors for JUN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JUN_HUMAN, P05412: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3
    endoplasmic reticulum3
    extracellular3
    mitochondrion3
    cytosol2
    plasma membrane2
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome TAS10918580
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IEA--
    GO:0005719nuclear euchromatin IDA19861239

    JUN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JUN About   (see all 182)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    NOD-like Receptor Signaling Pathways0.58
    Immune response IL 1 signaling pathway0.42
    Inflammasome Activation Pathways0.51
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    IL-1 Family Signaling Pathways0.44
    2Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development PDGF signaling via MAPK cascades0.41
    Signaling of Hepatocyte Growth Factor Receptor0.35
    3TWEAK Pathway
    TNFR1 Pathway0.56
    Fas Signaling0.35
    TNF Signaling0.55
    TWEAK Signaling Pathway0.31
    Apoptosis and survival TNFR1 signaling pathway0.52
    4G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    Activation of the AP-1 family of transcription factors0.00
    5B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for JUN (see all 10)
        Inflammasome Activation Pathways
    Adipocytokines & Insulin Signaling
    IL-17 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for JUN (see all 95)
        Toll-Like Receptors Pathway
    UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    JNK Pathway
    UVA-Induced MAPK Signaling

    1 Cell Signaling Technology (CST) Pathway for JUN
        MAP Kinase Signaling

    Selected Tocris Bioscience Pathways for JUN (see all 6)
        Akt Pathway
    Insulin Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for JUN (see all 54)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Development EGFR signaling pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD28 signaling

    Selected BioSystems Pathways for JUN (see all 80)
        Myometrial Relaxation and Contraction Pathways
    MAPK signaling pathway
    Focal Adhesion
    Apoptosis
    TGF Beta Signaling Pathway


    5 Reactome Pathways for JUN
        Oxidative Stress Induced Senescence
    Senescence-Associated Secretory Phenotype (SASP)
    FCERI mediated MAPK activation
    Pre-NOTCH Transcription and Translation
    Activation of the AP-1 family of transcription factors

    3 PharmGKB Pathways for JUN
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for JUN) (see all 32):
        MAPK signaling pathway
    ErbB signaling pathway
    Wnt signaling pathway
    Osteoclast differentiation
    Focal adhesion


    JUN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUN (see all 30): 
              Insulin Signaling Pathway in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JUN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JUN (P054121, 2, 3 ENSP000003602664) via UniProtKB, MINT, STRING, and/or I2D (see all 656)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOSP011001, 2, 3, ENSP000003062454EBI-852823,EBI-852851 MINT-8077940 MINT-8077771 MINT-8077923 MINT-68804 MINT-8077906 MINT-8077789 MINT-8077872 MINT-8077889 MINT-8077856 MINT-8077649 MINT-8077677 MINT-8077831 MINT-8077811 I2D: score=13 STRING: ENSP00000306245
    CITED1Q999661, 2, 3, ENSP000003885484EBI-852823,EBI-2624951 MINT-6628029 MINT-6628056 I2D: score=1 STRING: ENSP00000388548
    ENSG00000206427P486341, 3EBI-852823,EBI-347545 I2D: score=1 
    ENSG00000225164P486341, 3EBI-852823,EBI-347545 I2D: score=1 
    ENSG00000225748P486341, 3EBI-852823,EBI-347545 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 66):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001774microglial cell activation IEA--
    GO:0001836release of cytochrome c from mitochondria IEA--
    GO:0001889liver development IEA--
    GO:0001938positive regulation of endothelial cell proliferation IEA--

    JUN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for JUN
      Browse compounds at ApexBio 

    Browse Tocris compounds for JUN

    3 DrugBank Compounds for JUN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arsenic trioxideAcide Arsenieux [French] (see all 11)1327-53-3targetinducer12547826 12475910 12075113 12426127 12637567
    Vinblastine-- 865-21-4targetother/unknown15498923 16555127 16111654 17126817 12907245
    Irbesartan-- 138402-11-6targetother/unknown15210574 15133856

    Selected Novoseek inferred chemical compound relationships for JUN gene (see all 126)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 87.7 146 15034932 (2), 20490773 (2), 19405983 (2), 18487435 (2) (see all 99)
    12-o-tetradecanoylphorbol 13-acetate 80.8 449 2105946 (9), 1939341 (6), 11592962 (4), 9364213 (4) (see all 99)
    curcumin 75.7 201 16157375 (6), 15514944 (4), 9439980 (4), 15358181 (4) (see all 99)
    pd 98,059 75 87 19567187 (3), 18953964 (2), 17424890 (2), 15627897 (2) (see all 64)
    sb 203580 73 44 17424890 (2), 11367542 (2), 12093796 (1), 17257889 (1) (see all 37)
    phorbol 72.2 79 1901643 (3), 9037208 (2), 2122980 (2), 1496019 (2) (see all 49)
    n acetylcysteine 67.6 114 9043100 (4), 16298762 (3), 7835407 (2), 8662787 (2) (see all 57)
    retinoic acid 66.9 405 7489817 (7), 8637715 (7), 16052510 (7), 10329043 (7) (see all 99)
    leucine 66.7 213 15087451 (5), 1901988 (4), 1739975 (4), 8112339 (4) (see all 99)
    tyrosine 65 213 18073204 (6), 7524489 (4), 9442088 (4), 12388765 (3) (see all 99)



    JUN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for JUN gene: 
    NM_002228.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371222(uc001cze.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat JUN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JUN (see all 26):
    hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-429 hsa-miR-522 hsa-miR-139-5p hsa-miR-1258 hsa-miR-216b hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidJUN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for JUN
    Predesigned siRNA for gene silencing in human, mouse, rat JUN
    Clone
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    OriGene clones in human, mouse for JUN (see all 7)
    OriGene ORF clones in mouse, rat for JUN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JUN (NM_002228)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUN
    Primer
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    OriGene qPCR primer pairs and template standards for JUN
    OriGene qSTAR qPCR primer pairs in human, mouse for JUN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JUN
      QuantiTect SYBR Green Assays in human, mouse, rat JUN
      QuantiFast Probe-based Assays in human, mouse, rat JUN

    Selected AceView cDNA sequences (see all 886):

    AA555174 AI205975 BE217878 AA029968 AI913093 AA886738 BM747207 BM758600 
    AI302743 BG165177 AA430347 W76477 CA776995 AA808686 CA776233 AI288723 
    BI519326 NM_002228 CA952681 W52652 BM758620 BF477422 AI274034 BM748324 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JUN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTGTAAG
    JUN Expression
    About this image


    JUN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 26) fully expand
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Thalamus
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Bone Marrow
    JUN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JUN Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including JUN (see all 30): 
              Insulin Signaling Pathway in human mouse rat
              Stem Cell Transcription Factors in human mouse rat
              Antiviral Response in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Multiple Sclerosis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JUN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jun1 , 5 Jun oncogene5
    jun proto-oncogene1
    91.54(n)1
    96.98(a)1
      4 (43.34 cM)5
    164761  NM_010591.21  NP_034721.11 
     950490345 
    chicken
    (Gallus gallus)
    Aves JUN1 jun proto-oncogene 79.14(n)
    86.13(a)
      424673  NM_001031289.1  NP_001026460.1 
    lizard
    (Anolis carolinensis)
    Reptilia JUN6
    jun proto-oncogene
    83(a)
    1 ↔ 1
    4(101941554-101942495)
    African clawed frog
    (Xenopus laevis)
    Amphibia AJ243955.12   -- 82.18(n)    AJ243955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj36h072 wufj36h07 79.55(n)   335916  BC056597.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jra6
    Jun-related antigen
    32(a)
    1 → many
    2R(5983985-5986061)


    ENSEMBL Gene Tree for JUN (if available)
    TreeFam Gene Tree for JUN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JUN gene
    JUND2  JUNB2  
    2 SIMAP similar genes for JUN using alignment to 3 protein entries:     JUN_HUMAN (see all proteins):
    JUND    JUNB

    JUN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JUN (see all 120)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883624651,2
    --57356301(+) AGTTAC/TATCTG 1 -- ds50010--------
    rs13232871,2
    C,F,H--57356311(+) GTAGGC/TAGAAT 1 -- ds500127Minor allele frequency- T:0.11NS EA NA WA CSA 2225
    rs1812364601,2
    --57356333(+) ATTTCC/TCCAGA 1 -- ds50010--------
    rs46470211,2
    C,F,H--57356344(-) CAAACC/GTCAGC 1 -- ds500112Minor allele frequency- G:0.04NS EA NA WA CSA 1390
    rs13232881,2
    C,F,A,H--57356439(+) AGACTT/GATTCT 1 -- ds500126Minor allele frequency- G:0.32NS NA EA WA CSA 2656
    rs1147644671,2
    --57356456(+) AAACAA/GGGTTG 1 -- ds50010--------
    rs46470201,2
    C,F--57356623(-) TCTGAA/GTGAAA 1 -- ds50012Minor allele frequency- G:0.02NS EA 300
    rs1857341221,2
    --57356644(+) TAGTTC/TGACTC 1 -- ds50010--------
    rs46470191,2
    C,F--57356737(-) AGTTAT/CATACT 1 -- ds50012Minor allele frequency- C:0.03NS WA 174
    rs1905931761,2
    --57356866(+) AGGAAC/TTGTCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for JUN (59246463 - 59249785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for JUN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv26947CNV Loss19812545

    Human Gene Mutation Database (HGMD): JUN
    Site Specific Mutation Identification with PCR Assays
    2 Copy Number PCR Panels containing JUN:
    Oncogenes & Tumor Suppressor Genes 384HC
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing JUN
    DNA2.0 Custom Variant and Variant Library Synthesis for JUN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 165160    OMIM disorders: --

    Selected diseases for JUN (see all 210):    
    About MalaCards
    sarcoma    marek disease    campylobacteriosis    carotid body tumor
    myositis ossificans    sacrococcygeal teratoma    status epilepticus    htlv-1 associated myelopathy/tropical spastic paraparesis
    tropical spastic paraparesis    htlv-1 associated myelopathy    monocytic leukemia    recessive dystrophic epidermolysis bullosa
    spastic paraparesis    ocular hypertension    cholesteatoma    thyroid medullary carcinoma
    fibrodysplasia ossificans progressiva    glucocorticoid resistance    avian influenza    keloids

    10 diseases from the University of Copenhagen DISEASES database for JUN:
    Cancer     Vascular disease     Brain disease     Arthritis
    Toxic encephalopathy     Alzheimer's disease     Diabetes mellitus     Eye disease
    Gastrointestinal system disease     Asthma

    JUN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for JUN gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 69.3 732 7766308 (6), 10037172 (6), 10502734 (5), 19205384 (4) (see all 99)
    necrosis 67.7 217 9357820 (4), 7935377 (2), 12770614 (2), 1520341 (2) (see all 99)
    leukemia t-cell 62.1 15 11145887 (2), 12937177 (1), 8241024 (1), 7732661 (1) (see all 12)
    inflammation 58.9 110 16753225 (4), 19064304 (2), 18793328 (2), 12391249 (2) (see all 91)
    cancer 56.4 176 19653276 (4), 18008069 (3), 15884858 (2), 16135795 (2) (see all 99)
    myeloid leukemia 53.6 40 2122980 (3), 1310062 (2), 1737349 (2), 2174893 (2) (see all 24)
    neoplastic transformation 53.4 26 9652737 (2), 1801783 (2), 9092536 (2), 7766308 (1) (see all 18)
    breast cancer 46.6 225 8597534 (7), 17407600 (6), 16027729 (5), 17672916 (4) (see all 96)
    promyelocytic leukemia 45.4 9 11216470 (1), 15161980 (1), 15701643 (1), 20015448 (1) (see all 8)
    colon cancer 40 27 17510524 (3), 15139522 (2), 12503187 (2), 19782465 (2) (see all 19)

    Genetic Association Database (GAD): JUN
    Human Genome Epidemiology (HuGE) Navigator: JUN (136 documents)
    Tumor Gene Database (TGDB): JUN

    Export disorders for JUN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JUN gene, integrated from 10 sources (see all 4574):
    (articles sorted by number of sources associating them with JUN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and chromosomal localization of the functional intronless human JUN protooncogene. (PubMed id 3194415)1, 2, 3 Hattori K.... Karin M. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    2. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. (PubMed id 12547826)1, 7, 9 Li J....Liu Y. (J. Biol. Chem. 2003)
    3. Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. (PubMed id 16478997)1, 2, 9 Hung J.J.... Chang W.C. (Mol. Cell. Biol. 2006)
    4. Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PubMed id 12087103)1, 2, 9 Bower K.E.... McGuire K.L. (J. Biol. Chem. 2002)
    5. High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. (PubMed id 8662824)1, 2, 9 Junius F.K.... King G.F. (J. Biol. Chem. 1996)
    6. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. (PubMed id 8464713)1, 2, 9 Bannister A.J.... Jackson S.P. (Nucleic Acids Res. 1993)
    7. Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. (PubMed id 23624934)1, 2 Davies C.C....Behrens A. (EMBO J. 2013)
    8. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PubMed id 22307329)1, 2 Taira N....Yoshida K. (J. Clin. Invest. 2012)
    9. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3725 HGNC: 6204 AceView: JUN Ensembl:ENSG00000177606 euGenes: HUgn3725
    ECgene: JUN Kegg: 3725 H-InvDB: JUN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for JUN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JUN Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/jun/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JUN gene:
    Search GeneIP for patents involving JUN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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