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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

JUN Gene

protein-coding GIFtS: 72
GCID: GC01M059246

jun proto-oncogene

(Previous names: v-jun avian sarcoma virus 17 oncogene homolog, v-jun sarcoma...)

Explore 242 diseases affiliated with
JUN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Jun Proto-Oncogene¹ ²		AP1² ³
V-Jun Avian Sarcoma Virus 17 Oncogene Homolog¹ ² ³		P39¹
AP-1¹ ²		V-Jun Sarcoma Virus 17 Oncogene Homolog (Avian)¹
C-Jun¹		Enhancer-Binding Protein AP1²
Jun Oncogene¹ ²		Jun Activation Domain Binding Protein²
Activator Protein 1² ³		Transcription Factor AP-1²
Proto-Oncogene C-Jun² ³		V-Jun Sarcoma Virus 17 Oncogene Homolog²

External Ids:	HGNC: 6204¹	Entrez Gene: 3725²	Ensembl: ENSG00000177606⁷	OMIM: 165160⁵	UniProtKB: P05412³

Export aliases for JUN gene to outside databases

Previous GC identifers: GC01M059163 GC01M058161 GC01M058604 GC01M058616 GC01M058958 GC01M057356

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JUN:

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to

the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This

gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in

human malignancies. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes

activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling

pathway stimulation

Gene Wiki entry for JUN (C-jun)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the JUN gene promoter:
USF1 STAT5A GATA-2 HEN1 MZF-1 POU2F1 CP2 USF-1 POU2F1a c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): JUN promoter sequence

Search SABiosciences Chromatin IP Primers for JUN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JUN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32-p31 Ensembl cytogenetic band: 1p32.1 HGNC cytogenetic band: 1p32-p31

JUN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JUN gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M059246: view genomic region (about GC identifiers)

Start:	59,246,463 bp from pter	End:	59,249,785 bp from pter
Size:	3,323 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412 (See protein sequence)

Recommended Name: Transcription factor AP-1

Size: 331 amino acids; 35676 Da

Subunit: Heterodimer with either FOS or BATF3 or ATF7. The ATF7/JUN heterodimer is essential for ATF7 transactivation

activity. Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity).

Interacts with HIVEP3 and MYBBP1A (By similarity). Interacts with SP1, SPIB and TCF20. Interacts with COPS5; the

interaction leads indirectly to its phosphorylation. Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the

AP1 promoter site. The SMAD3/SMAD4 heterodimer acts syngernistically with the JUN/FOS heterodimer to activate

transcription in response to TGF-beta. Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3

(via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the

SMAD3/SMAD4/JUN/FOS/complex. Interacts with RNF187. Binds to HIPK3

Subcellular location: Nucleus

6 PDB 3D structures from and Proteopedia for JUN:

1A02 (3D)

1FOS (3D)

1JNM (3D)

1JUN (3D)

1S9K (3D)

1T2K (3D)

Secondary accessions: Q96G93

Explore the universe of human proteins at neXtProt for JUN: NX_P05412

Post-translational modifications:

Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3.

Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239.

Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA.

Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation

and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding

activity¹

Acetylated at Lys-271 by EP300¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05412

JUN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002219.1

ENSEMBL proteins:

ENSP00000360266

Reactome Protein details: P05412
Human Recombinant Protein Products for JUN:

	EMD Millipore Purified and/or Recombinant JUN Protein
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	Enzo Life Sciences proteins for JUN
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	Novus Biologicals JUN Proteins Novus Biologicals JUN Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for JUN
	Uscn Proteins for JUN

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000228	nuclear chromosome	TAS	10918580
GO:0000790	nuclear chromatin	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005667	transcription factor complex	IEA	--

JUN for ontologies About GeneDecksing

JUN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of JUN
	R&D Systems Antibodies for JUN (c-Jun)
	Cell Signaling Technology (CST) Antibodies for JUN
	OriGene Antibodies (see all 49): JUN OriGene Custom Antibody Services for JUN
	GenScript Superior Antibodies for JUN
	Novus Biologicals JUN Antibodies
	Abcam antibodies for JUN
	Uscn Antibodies for JUN
	ThermoFisher Antibody for JUN

Assay Products for JUN:

	EMD Millipore Kits and Assays for the Analysis of JUN
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for JUN (c-Jun) (see all)
	GenScript Custom Assay Services for JUN
	Cell Signaling Technology (CST) Sandwich ELISA Kits for JUN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for JUN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

JUN for domains About GeneDecksing

5 InterPro domains/families:

IPR004827 bZIP

IPR008917 Euk_TF_DNA-bd

IPR002112 Leuzip_Jun

IPR015558 C_Jun

IPR005643 JNK

Graphical View of Domain Structure for InterPro Entry P05412

ProtoNet protein and cluster: P05412

3 Blocks protein families:

IPB002112 Jun transcription factor signature

IPB005643 Jun-like transcription factor

IPB011616 bZIP transcription factor

UniProtKB/Swiss-Prot: JUN_HUMAN, P05412

Similarity: Belongs to the bZIP family. Jun subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: JUN_HUMAN, P05412

Function: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes

activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling

pathway stimulation

Genatlas biochemistry entry for JUN:

avian sarcoma virus 17 (v-jun) oncogene homolog,ligand induced,immediate (primary ) early response gene interacting

with MYC to regulate AP1 genes

Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	IDA	19861239
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IEA	--
GO:0001102	RNA polymerase II activating transcription factor binding	IPI	19861239
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	IC	19861239
GO:0003677	DNA binding	TAS	2825349

JUN for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for JUN:

Decreased influenza A H1N1 (A/	Decreased influenza A H1N1 (A/	Decreased influenza A/WSN/33 r	Increased cell death HMECs cel
Upregulation of Wnt/beta-caten

15/18 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Jun) (see all 18):

behavior/neurological	cardiovascular system	cellular	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	nervous system	no phenotypic analysis	normal

JUN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for JUN: Jun^tm1Pa Jun^tm1Wag

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for JUN

		10/2768 SABiosciences Target genes for JUN (see all 2768):
		A2ML1 A4GALT AAA1 AAAS AATF ABCA1 ABCA12 ABCA9 ABCB1 ABCB6

miRNA Products:		miRTarBase miRNAs that target JUN: hsa-mir-30a (MIRT005128)

		OriGene 3'-UTR Clone: JUN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUN
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate JUN (see all 26):
		hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-429 hsa-miR-522 hsa-miR-139-5p hsa-miR-1258 hsa-miR-216b hsa-miR-1285

		SwitchGear 3'UTR luciferase reporter plasmid: JUN 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of JUN Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUN (see all 7) OriGene shRNA RFP: JUN OriGene siRNA: JUN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUN
		Sirion Biotech Custom design and validation of potent shRNA sequences against JUN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for JUN
			Sirion Biotech Customized adenovirus for overexpression of JUN Sirion Biotech Customized adenovirus for potent knockdown of JUN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JUN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JUN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: JUN (NM_002228)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for JUN
		Search LifeMap BioReagents cell lines for JUN
		Sirion Biotech Customized stable knockdown cell line services for JUN Sirion Biotech Customized inducible knockdown cell line services for JUN Sirion Biotech Customized stable overexpressing cell line services for JUN Sirion Biotech Customized inducible overexpressing cell line services for JUN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JUN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/164 super-pathways (see all 164) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/19 pathways (see all 19)
TRAF6 Mediated Induction of proinflammatory cytokines	1.00	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MAP kinase activation in TLR cascade	0.88	Toll Like Receptor 2 (TLR2) Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	MyD88:Mal cascade initiated on plasma membrane	0.78
Toll Like Receptor 10 (TLR10) Cascade	0.86	TRIF-mediated TLR3/TLR4 signaling	0.73

Development HGF signaling pathway

8/13 pathways (see all 13)
Development HGF signaling pathway	1.00	Apoptosis and survival_Role of CDK5 in neuronal death and survival	0.24
Development_HGF signaling pathway	0.78	Apoptosis and survival Role of CDK5 in neuronal death and survival	0.24
Development_Neurotrophin family signaling	0.45	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
Development Neurotrophin family signaling	0.45	Neurotrophin signaling pathway	0.20

ErbB4 Pathway

8/9 pathways (see all 9)
ErbB Family Pathway	0.59	Thrombopoietin Pathway	0.43
Prolactin Signaling	0.54	LPS Stimulated MAPK Signaling	0.36
ErbB2-ErbB3 Heterodimers	0.47	TREM1 Pathway	0.32
IL-2 Pathway	0.46	HMGB1 Pathway	0.32

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

G-protein signaling Ras family GTPases in kinase cascades (scheme)	1.00	Immune response_Oncostatin M signaling via MAPK in human cells	0.39
G-protein signaling_Ras family GTPases in kinase cascades (scheme)	1.00	Immune response Oncostatin M signaling via MAPK in human cells	0.39
MAPK Cascade	0.44	Activation of the AP-1 family of transcription factors	0.33

Development EGFR signaling pathway

Development EGFR signaling pathway	1.00	Development GDNF family signaling	0.45
Development_EGFR signaling pathway	0.87	EGF Pathway	0.39
Development_GDNF family signaling	0.45	GDNF-Family Ligands and Receptor Interactions	0.21

Pathway sources
See GeneCards unified pathways
Show all pathways

5/51 EMD Millipore Pathways for JUN (see all 51)

	Development Activation of ERK by Alpha-1 adrenergic receptors
	Immune response CD16 signaling in NK cells
	Immune response MIF-mediated glucocorticoid regulation
	Immune response MIF in innate immunity response
	Immune response IL-1 signaling pathway

5 R&D Systems Pathways for JUN

	Inflammasome Activation Pathways
	Adipocytokines & Insulin Signaling
	Th1 Differentiation
	Toll-Like receptor Signaling Pathways
	TGF-beta Signaling Pathways

5/95 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JUN (see all 95)

	Toll-Like Receptors Pathway
	UVB-Induced MAPK Signaling
	Molecular Mechanisms of Cancer
	JNK Pathway
	UVA-Induced MAPK Signaling

1 Cell Signaling Technology (CST) Pathway for JUN

MAP Kinase Signaling

5/6 Tocris Bioscience Pathways for JUN (see all 6)

	Akt Pathway
	Insulin Pathway
	Toll-like Receptor Pathway
	VEGF Pathway
	MAPK Pathway

5/54 GeneGo (Thomson Reuters) Pathways for JUN (see all 54)

	Development A2A receptor signaling
	Immune response MIF in innate immunity response
	Development EGFR signaling pathway
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
	Immune response CD28 signaling

5/75 BioSystems Pathways for JUN (see all 75)

	Focal Adhesion
	Wnt Signaling Pathway and Pluripotency
	Apoptosis
	Estrogen signaling pathway
	Senescence and Autophagy

5/23 Reactome Pathways for JUN (see all 23)

	Toll Like Receptor 2 (TLR2) Cascade
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	TRAF6 Mediated Induction of proinflammatory cytokines
	Toll Like Receptor 7/8 (TLR7/8) Cascade

3 PharmGKB Pathways for JUN

	EGFR Inhibitor Pathway, Pharmacodynamics
	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
	Vemurafenib Pathway, Pharmacodynamics

5/19 Kegg Pathways (Kegg details for JUN) (see all 19):

	MAPK signaling pathway
	ErbB signaling pathway
	Wnt signaling pathway
	Osteoclast differentiation
	Focal adhesion

JUN for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for JUN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/477 Interacting proteins for JUN (P05412^{1, 2, 3} ENSP00000360266⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 477)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FOS	P01100¹^,²^,³, ENSP00000306245⁴	EBI-852823,EBI-852851 MINT-8077940 MINT-8077771 MINT-8077923 MINT-68804 MINT-8077906 MINT-8077789 MINT-8077872 MINT-8077889 MINT-8077856 MINT-8077649 MINT-8077677 MINT-8077831 MINT-8077811 I2D: score=13 STRING: ENSP00000306245
DDX21	Q9NR30²^,³, ENSP00000346120⁴	MINT-14075 MINT-14076 MINT-14077 I2D: score=4 STRING: ENSP00000346120
CITED1	Q99966²^,³, ENSP00000388548⁴	MINT-6628029 MINT-6628056 I2D: score=1 STRING: ENSP00000388548
ETS1	P14921¹^,³, ENSP00000376436⁴	EBI-852823,EBI-913209 I2D: score=4 STRING: ENSP00000376436
APLP2	Q06481¹^,³, ENSP00000263574⁴	EBI-852823,EBI-79306 I2D: score=3 STRING: ENSP00000263574

About this table

Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IEA	--
GO:0001774	microglial cell activation	IEA	--
GO:0001836	release of cytochrome c from mitochondria	IEA	--
GO:0001889	liver development	IEA	--
GO:0001938	positive regulation of endothelial cell proliferation	IEA	--

JUN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

JUN for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for JUN

Browse Tocris compounds for JUN

3 DrugBank Compounds for JUN About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Arsenic trioxide	Acide Arsenieux [French] (see all 11)	1327-53-3	target	inducer	12547826 12475910 12075113 12426127 12637567
Vinblastine	--	865-21-4	target	other/unknown	15498923 16555127 16111654 17126817 12907245
Irbesartan	--	138402-11-6	target	other/unknown	15210574 15133856

10/126 Novoseek chemical compound relationships for JUN gene (see all 126) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sp 600125	87.7	146	15034932 (2), 20490773 (2), 19405983 (2), 18487435 (2) (see all 99)
12-o-tetradecanoylphorbol 13-acetate	80.8	449	2105946 (9), 1939341 (6), 11592962 (4), 9364213 (4) (see all 99)
curcumin	75.7	201	16157375 (6), 15514944 (4), 9439980 (4), 15358181 (4) (see all 99)
pd 98,059	75	87	19567187 (3), 18953964 (2), 17424890 (2), 15627897 (2) (see all 64)
sb 203580	73	44	17424890 (2), 11367542 (2), 12093796 (1), 17257889 (1) (see all 37)
phorbol	72.2	79	1901643 (3), 9037208 (2), 2122980 (2), 1496019 (2) (see all 49)
n acetylcysteine	67.6	114	9043100 (4), 16298762 (3), 7835407 (2), 8662787 (2) (see all 57)
retinoic acid	66.9	405	7489817 (7), 8637715 (7), 16052510 (7), 10329043 (7) (see all 99)
leucine	66.7	213	15087451 (5), 1901988 (4), 1739975 (4), 8112339 (4) (see all 99)
tyrosine	65	213	18073204 (6), 7524489 (4), 9442088 (4), 12388765 (3) (see all 99)

Search CenterWatch for drugs/clinical trials and news about JUN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for JUN gene:

NM_002228.3

Unigene Cluster for JUN:

Jun proto-oncogene

Hs.696684 [show with all ESTs]

Unigene Representative Sequence: NM_002228

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000371222(uc001cze.3)

miRNA Products:		OriGene 3'-UTR Clone: JUN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JUN
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate JUN (see all 26):
		hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-429 hsa-miR-522 hsa-miR-139-5p hsa-miR-1258 hsa-miR-216b hsa-miR-1285

		SwitchGear 3'UTR luciferase reporter plasmid: JUN 3' UTR sequence

Inhib. RNA Products:		EMD Millipore RNAi Products for the Analysis of JUN Gene knock-down
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JUN (see all 7) OriGene shRNA RFP: JUN OriGene siRNA: JUN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JUN
		Sirion Biotech Custom design and validation of potent shRNA sequences against JUN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JUN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JUN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: JUN (NM_002228)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JUN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JUN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JUN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat JUN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JUN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JUN

Additional cDNA sequence:

AK307137.1 BC002646.2 BC006175.1 BC009874.2 BC068522.1 BT019759.1 CR541724.1 CR541752.1

22 DOTS entries:

DT.97762702 DT.100044313 DT.121359986 DT.121359920 DT.100863059 DT.450792 DT.100675414 DT.100675418

DT.100851939 DT.121359919 DT.121359948 DT.92473418 DT.95264854 DT.121359935 DT.95107720 DT.91897383

DT.92473595 DT.95132043 DT.100804761 DT.121359950 DT.91843574 DT.100675423

24/886 AceView cDNA sequences (see all 886):

AI288723 BM750603 BI962628 AI832787 BU617877 AA476238 BI490338 AA877624

BM757948 BM745441 AA854928 AA043402 BM748324 BI792812 H21690 CD370643

AA424673 BQ268811 AA343833 CA776233 BM757664 CA772714 BM748322 AA962248

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

JUN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTTGTAAG

About this image

JUN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

9 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Mesenchymal Condensate Cells

Bone, Cartilage

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Bone

Brain

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See JUN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JUN

SOURCE GeneReport for Unigene cluster: Hs.696684

SABiosciences Expression via Pathway-Focused PCR Arrays including JUN (see all 30):

Insulin Signaling Pathway in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Antiviral Response in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Multiple Sclerosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JUN Browse OriGene validated miRNA SYBR primer pairs
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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for JUN gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	JUN¹	jun proto-oncogene	80.11(n) 87.74(a)		424673 NM_001031289.1 NP_001026460.1
lizard (Anolis carolinensis)	Reptilia	JUN⁶	--	86(a)	1 ↔ 1	4(101941554-101942495)
African clawed frog (Xenopus laevis)	Amphibia	AJ243955.1²	--	82.18(n)		AJ243955.1
zebrafish (Danio rerio)	Actinopterygii	wufj36h07²	wufj36h07	79.55(n)		335916 BC056597.1
fruit fly (Drosophila melanogaster)	Insecta	Jra¹	Jun-related antigen	53.99(n) 43.16(a)		36057 NM_057238.4 NP_476586.1

ENSEMBL Gene Tree for JUN (if available)
TreeFam Gene Tree for JUN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for JUN gene

JUND² JUNB²

2 SIMAP similar genes for JUN using alignment to 3 protein entries: JUN_HUMAN (see all proteins):

JUND JUNB

JUN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12040370^1,2	C	--	57359191(+)	`TTTCTC/TTAAGA`	1	--	ut5¹		1	NA	2
rs4647011^1,2	C,F	--	57359240(-)	`AGCTGG/TTGAGG`	1	--	ut5¹ ese³		2	NS WA	158
rs4647010^1,2	C	--	57359592(-)	`CAAGAG/CAAGAA`	1	--	ut5¹ ese³ trp³		8	NS NA MN	558
rs4647009^1,2	C,F	--	57359684(-)	`TGGCA-/CAGAGTC`	1	--	ut5¹		6	NS MN	556
rs4647008^1,2	C,F	--	57359769(-)	`CAGCGG/TTACCC`	1	--	ut5¹ ese³		8	NS NA MN	556
rs3748814^1,2	C,F,H	--	57359892(+)	`GCTCTG/AGGCAG`	1	--	ut5¹ ese³		15	EA MN NS NA	2772
rs4647006^1,2	C,F,H	--	57360011(-)	`AGCAGA/C/TGAGGC`	2	--	ut5¹ ese³		5	NS NA CSA	352
rs4647005^1,2	C	--	57360260(-)	`gaaagA/GagggC`	1	--	us2k¹ trp³		3	NS NA	170
rs4647003^1,2	C,F	--	57360340(-)	`GGGCGG/AGCCGG`	1	--	us2k¹		3	NS NA	288
rs4647002^1,2	C,F	--	57360417(-)	`GTTGCG/CAGCGT`	1	--	us2k¹		4	NS NA WA	294

HapMap Linkage Disequilibrium report for JUN (59246463 - 59249785 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JUN
1 CNV: 63848
Human Gene Mutation Database (HGMD): JUN

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing JUN:

Oncogenes & Tumor Suppressor Genes 384HC

WNT Signaling

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JUN

DNA2.0 Custom Variant and Variant Library Synthesis for JUN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

JUN for disorders           About GeneDecksing

OMIM gene information: 165160    OMIM disorders: --

20/242 diseases for JUN (see all 242):    About MalaCards

htlv-1 associated myelopathy/tropical spastic paraparesis sarcoma htlv-1 associated myelopathy recessive dystrophic epidermolysis bullosa

tropical spastic paraparesis fibrodysplasia ossificans progressiva estrogen-receptor negative breast cancer splenic marginal zone lymphoma

spinal cord injury malignant peripheral nerve sheath tumor middle ear cholesteatoma anaplastic large cell lymphoma

spastic paraparesis human t-cell leukemia virus type 1 status epilepticus epidermolysis bullosa

dna topoisomerase ii dna topoisomerase i non-small cell lung carcinoma sacrococcygeal teratoma

9 diseases from the University of Copenhagen DISEASES database for JUN:

Cancer Vascular disease Toxic encephalopathy Alzheimer's disease

Arthritis Diabetes mellitus Parkinson's disease Gastrointestinal system disease

Eye disease

10/95 Novoseek disease relationships for JUN gene (see all 95) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	69.3	732	7766308 (6), 10037172 (6), 10502734 (5), 19205384 (4) (see all 99)
necrosis	67.7	217	9357820 (4), 7935377 (2), 12770614 (2), 1520341 (2) (see all 99)
leukemia t-cell	62.1	15	11145887 (2), 12937177 (1), 8241024 (1), 7732661 (1) (see all 12)
inflammation	58.9	110	16753225 (4), 19064304 (2), 18793328 (2), 12391249 (2) (see all 91)
cancer	56.4	176	19653276 (4), 18008069 (3), 15884858 (2), 16135795 (2) (see all 99)
myeloid leukemia	53.6	40	2122980 (3), 1310062 (2), 1737349 (2), 2174893 (2) (see all 24)
neoplastic transformation	53.4	26	9652737 (2), 1801783 (2), 9092536 (2), 7766308 (1) (see all 18)
breast cancer	46.6	225	8597534 (7), 17407600 (6), 16027729 (5), 17672916 (4) (see all 96)
promyelocytic leukemia	45.4	9	11216470 (1), 15161980 (1), 15701643 (1), 20015448 (1) (see all 8)
colon cancer	40	27	17510524 (3), 15139522 (2), 12503187 (2), 19782465 (2) (see all 19)

Human Genome Epidemiology (HuGE) Navigator: JUN (136 documents)
Tumor Gene Database (TGDB): JUN

Export disorders for JUN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for JUN gene, integrated from 9 sources (see all 4497):
(articles sorted by number of sources associating them with JUN)

Utopia: connect your pdf to the dynamic
world of online information

Structure and chromosomal localization of the functional intronless human JUN protooncogene. (PubMed id 3194415)^{1, 2, 3} Hattori K.... Karin M. (1988)
Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts. (PubMed id 12547826)^{1, 7, 9} Li J....Liu Y. (2003)
Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12(S)-lipoxygenase gene transcription. (PubMed id 16478997)^{1, 2, 9} Hung J.J....Chang W.C. (2006)
Correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions. (PubMed id 12087103)^{1, 2, 9} Bower K.E....McGuire K.L. (2002)
High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer. (PubMed id 8662824)^{1, 2, 9} Junius F.K.... King G.F. (1996)
c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. (PubMed id 8464713)^{1, 2, 9} Bannister A.J.... Jackson S.P. (1993)
DYRK2 priming phosphorylation of c-Jun and c-Myc modul ates cell cycle progression in human cancer cells. (PubMed id 22307329)^{1, 2} Taira N....Yoshida K. (2012)
Identification of a co-activator that links growth fa ctor signalling to c-Jun/AP-1 activation. (PubMed id 20852630)^{1, 2} Davies C.C....Behrens A. (2010)
Activation of Polo-like kinase 3 by hypoxic stresses. (PubMed id 18650425)^{1, 2} Wang L....Lu L. (2008)
Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. (PubMed id 17804415)^{1, 2} Wang L....Lu L. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3725	HGNC: 6204	AceView: JUN	Ensembl:ENSG00000177606	euGenes: HUgn3725
ECgene: JUN	Kegg: 3725	H-InvDB: JUN

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for JUN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for JUN	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/jun/

Intellectual Property for JUN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for JUN gene:
Search GeneIP for patents involving JUN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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jun proto-oncogene

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HERPES
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JUN Gene

jun proto-oncogene

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