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Aliases & Descriptions for JUB
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases Ajuba 2 MGC15563 1 , 2 OTTHUMP00000164552 2 ajuba 2
Descriptions jub, ajuba homolog (Xenopus laevis) 2
Search outside databases for aliases for JUB genePrevious GC identifers: GC14M020813 GC14M017228 GC14M021431 GC14M021430
Summaries for JUB (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1 Function : Components of cellular adhesives complexes. Contribute to cell fate determination andregulate cell proliferation and differentiation. Involved in the regulation of actin cytoskeletondynamics and cell migration. Contributes to the linking and/or strengthening of epitheliacell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May beinvolved in signal transduction from cell adhesion sites to the nucleus. Plays a important role inregulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Is also a component ofthe IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing theassembly and activity of the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Can functions asadapter molecules in the formation of large multiprotein complexes that form on DNA and thatinfluence transcription
Gene Wiki entry for JUB
Genomic Location for JUB
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the JUB gene Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2 JUB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M022510:
(about GC identifiers )
Start:
22,510,249 bp from pter
End:
22,521,691 bp from pter
Size:
11,443 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for JUB
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1 (See
protein sequence )Recommended Name: Protein ajuba Size : 538 amino acids; 56934 Da
Subunit : Interacts with AURKA/Aurora-A during mitosis and both proteins are phosphorylated as theyform a complex. Interacts with CTNNA1/alpha-catenin and with F-actin. Interacts with LATS2 duringmitosis and this complex regulates organization of the spindle apparatus through recruitment ofgamma-tubulin to the centrosome. Interacts with GRB2 and PIP5K1A (By similarity). Forms a complexwith SQSTM1, PRKCZ and TRAF6. Interacts with SLC1A2 (By similarity)
Subcellular location : Cytoplasm, cytoskeleton. Cell membrane. Cell junction. Nucleus. Centrosome.Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase.Preferentially co-localizes with cadherin-adhesive complexes at sites of cell-cell contacts
Miscellaneous : 'Ajuba' means 'curiosity' in Urdu, an Indian dialect
Post-translational modifications:
Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_116265.1 NP_932352.1 ENSEMBL proteins: ENSP00000380543 ENSP00000354491 ENSP00000262713 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): JUB 5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8
):
About this table Antibodies for JUB: Assays for JUB:
Protein
Domains/ Families for JUB(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96IF1 ProtoNet protein and cluster: Q96IF1
1 Blocks protein family : IPB001781 Zn-binding protein UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1 Domain : LIM region interacts with CTNNA1. The preLIM region binds directly actin filamentsDomain : LIM-2 and LIM-3 domains mediate the interaction with the N-terminal region of AURKA. Theassociation between LATS2 and JUB required the second LIM domain of JUB Similarity : Belongs to the zyxin/ajuba familySimilarity : Contains 3 LIM zinc-binding domains
Gene Function for JUB
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_198086 Applied Biosystems Silencer ® siRNAs for JUB Sigma-Aldrich siRNA for JUB Sigma-Aldrich shRNA for JUB Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_032876                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_032876                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_032876  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032876 UniProtKB/Swiss-Prot: JUB_HUMAN, Q96IF1 Function : Components of cellular adhesives complexes. Contribute to cell fate determination andregulate cell proliferation and differentiation. Involved in the regulation of actin cytoskeletondynamics and cell migration. Contributes to the linking and/or strengthening of epitheliacell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May beinvolved in signal transduction from cell adhesion sites to the nucleus. Plays a important role inregulation of the kinase activity of AURKA/Aurora-A for mitotic commitment. Is also a component ofthe IL-1 signaling pathway modulating IL-1-induced NF-kappa-B activation by influencing theassembly and activity of the PRKCZ/SQSTM1/TRAF6 multiprotein signaling complex. Can functions asadapter molecules in the formation of large multiprotein complexes that form on DNA and thatinfluence transcription
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Jub) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for JUB
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for JUB 5/17 Interacting proteins for JUB (ENSP00000262713 3 Q96IF1 2 ) via UniProtKB, MINT, and/or STRING (see all 17
)About this table 5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
):
About this table
Drugs & Compounds for JUB (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for JUB
Transcripts for JUB(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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ESTs according to GeneTide ,
exon structure from GeneLoc ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_198086 Sigma-Aldrich siRNA for JUB Sigma-Aldrich shRNA for JUB Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_032876 NM_198086
REFSEQ mRNAs for JUB gene (2 alternative transcripts): NM_032876.4 NM_198086.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032876 NM_198086
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_032876                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_032876                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_032876  
Additional cDNA sequence: AK025567.1 AK096128.1 AY169959.1 BC007580.1 BC016733.1 BC034968.2
10 DOTS entries : DT.100775739 DT.455766 DT.120777830 DT.92426492 DT.102836338 DT.100775734 DT.100737442 DT.40129291 DT.120777678 DT.100775735
24/146 AceView cDNA sequences (see all 146
):NM_198086 AI918246 BM680549 BU543883 BQ958701 CN482905 AY169959 NM_032876 BM479543 BU149830 D12422 BM718100 CA442366 CB135297 BQ439546 BC007580 BQ232031 BI260853 BU163376 BM800674 AW169067 CB105981 CB105505 CB106070
highest scoring ESTs for JUB :BM046574 BM800674 BG490419 CB150160 CK903938 AA152464 AI289311 BC034968 BG117516 BG753539
Unigene Cluster for JUB: Jub, ajuba homolog (Xenopus laevis) Hs.655832 [show with all ESTs ] Unigene Representative Sequence: NM_032876 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000397388
ENST00000361265
ENST00000262713
Expression for JUB
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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JUB expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for JUB 1 / 2 / 3
7 probe-sets matching JUB gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTTTGGATATSOURCE GeneReport for Unigene cluster: Hs.655832
Orthologs for JUB
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for JUB gene from 5 species
About this table Species with no ortholog for JUB ENSEMBL Gene Tree for JUB Paralogs for JUB (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for JUB gene FBLIM1 2 WTIP 2 ZYX 2 LIMD1 2
SNPs/Variants for JUB (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for JUB (up to first 250kb)
Disorders & Mutations for JUB
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 609066
Medical News for JUB (Possibly Related Articles in
Doctor's Guide )
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--
Publications for JUB (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/22 PubMed articles for JUB gene (see all 22
): LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. (PubMed id 16413547) 3, 4 Abe Y.... Yamamoto T. (2006) The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex. (PubMed id 15870274) 3, 4 Feng Y. and Longmore G.D. (2005) The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. (PubMed id 12417594) 3, 4 Marie H.... Braga V.M. (2003) Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells. (PubMed id 13678582) 3, 4 Hirota T.... Saya H. (2003) Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner. (PubMed id 10330178) 2, 3 Goyal R.K....Longmore G.D. (1999) Ajuba: a new microtubule-associated protein that interacts with BUBR1 and Aurora B at kinetochores in metaphase. (PubMed id 18710370) 3 Ferrand A....Birnbaum D. (2009) Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3beta-mediated phosphorylation of beta-catenin. (PubMed id 17621269) 3 Haraguchi K....Yamamoto T. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008) Ajuba functions as a histone deacetylase-dependent co-repressor for autoregulation of the growth factor-independent-1 transcription factor. (PubMed id 18805794) 3 Montoya-Durango D.E....Grimes H.L. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008)
Search for JUB
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Genome Databases showing JUB
(According to
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HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing JUB
(According to HUGE )
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Specialized Databases showing JUB (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for JUB (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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