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JTB Gene

protein-coding   GIFtS: 54
GCID: GC01M153946

Jumping Translocation Breakpoint

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jumping Translocation Breakpoint1 2     HJTB2
Jumping Translocation Breakpoint Protein2 3     HSPC2222
Prostate Androgen-Regulated Protein2 3     hJT2
PAR2 5     Protein JTB2
Prostate Androgen-Regulated Gene1     PAR Protein3

External Ids:    HGNC: 62011   Entrez Gene: 108992   Ensembl: ENSG000001435437   OMIM: 6046715   UniProtKB: O760953   

Export aliases for JTB gene to outside databases

Previous GC identifers: GC01M151763 GC01M149677 GC01M150722 GC01M151163 GC01M150759 GC01M152213 GC01M125309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JTB Gene:
JTB (jumping translocation breakpoint) is a protein-coding gene. Diseases associated with JTB include abdominal tuberculosis, and lymph node tuberculosis. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation.
May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB
activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria
and reduces mitochondrial membrane potential (By similarity)

Gene Wiki entry for JTB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the JTB gene promoter:
         AP-2gamma   C/EBPalpha   PPAR-gamma1   POU2F1   POU2F1a   AP-2beta   ZIC2/Zic2   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJTB promoter sequence
   Search Chromatin IP Primers for JTB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JTB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

JTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JTB gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M153946:  view genomic region     (about GC identifiers)

Start:
153,946,745 bp from pter      End:
153,950,451 bp from pter
Size:
3,707 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 (See protein sequence)
Recommended Name: Protein JTB precursor  
Size: 146 amino acids; 16358 Da
Subunit: Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of
BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B
1 PDB 3D structure from and Proteopedia for JTB:
2KJX (3D)    
Secondary accessions: O95442 Q6IB19 Q9P0Q4
Alternative splicing: 2 isoforms:  O76095-1   O76095-2   

Explore the universe of human proteins at neXtProt for JTB: NX_O76095

Explore proteomics data for JTB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys69

  • See JTB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006685.1  
    ENSEMBL proteins: 
     ENSP00000271843   ENSP00000349069   ENSP00000357578   ENSP00000395250  

    JTB Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for JTB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008657 JTB

    Graphical View of Domain Structure for InterPro Entry O76095

    ProtoNet protein and cluster: O76095

    1 Blocks protein domain: IPB008657 Jumping translocation breakpoint

    UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
    Similarity: Belongs to the JTB family


    JTB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JTB_HUMAN, O76095
    Function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation.
    May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis.
    The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and
    segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB
    activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria
    and reduces mitochondrial membrane potential (By similarity)
    Induction: Protein levels increase during the S phase of the cell cycle, are highest during G2 and mitosis, and
    decrease to low levels at G1. Levels are lowest at the transition from G1 to S phase

         Genatlas biochemistry entry for JTB:
    jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019901protein kinase binding IDA--
         
    JTB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for JTB:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JTB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JTB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JTB

    miRNA
    Products:
        
    miRTarBase miRNAs that target JTB:
    hsa-mir-197-3p (MIRT048073), hsa-mir-222-3p (MIRT046770)

    Block miRNA regulation of human, mouse, rat JTB using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate JTB:
    hsa-miR-3667-5p hsa-miR-539 hsa-miR-617
    SwitchGear 3'UTR luciferase reporter plasmidJTB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat JTB

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JTB

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JTB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JTB_HUMAN, O76095: Membrane; Single-pass type I membrane protein (Potential). Mitochondrion (By similarity).
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
    Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody
    during telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    extracellular3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005813colocalizes with centrosome IDA--
    GO:0005819colocalizes with spindle IDA--
    GO:0005887integral component of plasma membrane TAS10321732

    JTB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JTB
    Interactions:

        Search GeneGlobe Interaction Network for JTB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for JTB (O760952, 3 ENSP000002718434) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZXDCQ2QGD72, 3, ENSP000003743594MINT-8258793 I2D: score=2 STRING: ENSP00000374359
    LIG3P499163, ENSP000003677874I2D: score=1 STRING: ENSP00000367787
    UBE2SQ167633, ENSP000002645524I2D: score=1 STRING: ENSP00000264552
    UBR4ENSP000003644034STRING: ENSP00000364403
    AURKAENSP000002169114STRING: ENSP00000216911
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP--
    GO:0006915apoptotic process ----
    GO:0007067mitosis IMP--
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0042127regulation of cell proliferation IEA--

    JTB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JTB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for JTB gene: 
    NM_006694.3  

    Unigene Cluster for JTB:

    Jumping translocation breakpoint
    Hs.6396  [show with all ESTs]
    Unigene Representative Sequence: BQ062593
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000271843(uc001fds.3) ENST00000356648 ENST00000368589 ENST00000428469
    ENST00000461365 ENST00000471173
    miRNA
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    Block miRNA regulation of human, mouse, rat JTB using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate JTB:
    hsa-miR-3667-5p hsa-miR-539 hsa-miR-617
    SwitchGear 3'UTR luciferase reporter plasmidJTB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat JTB
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    GenScript: all cDNA clones in your preferred vector: JTB (NM_006694)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JTB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JTB
    Primer
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    OriGene qPCR primer pairs and template standards for JTB
    OriGene qSTAR qPCR primer pairs in human, mouse for JTB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JTB
      QuantiTect SYBR Green Assays in human, mouse, rat JTB
      QuantiFast Probe-based Assays in human, mouse, rat JTB

    Additional mRNA sequence: 

    AB016488.1 AF115850.2 AF131797.1 AF151056.1 AK312106.1 BC000499.1 BC000996.2 BC001363.1 
    BC001667.1 BC004239.1 BC019277.1 BT007285.1 CR456985.1 

    Selected DOTS entries (see all 26):

    DT.421099  DT.75130019  DT.75133749  DT.100817416  DT.100817421  DT.97844584  DT.95277027  DT.92453787 
    DT.95277035  DT.121436598  DT.121436576  DT.121436568  DT.100039009  DT.95277024  DT.100817411  DT.100817420 
    DT.95155142  DT.92453774  DT.121436377  DT.95104852  DT.97844583  DT.92453775  DT.95277026  DT.100817403 

    Selected AceView cDNA sequences (see all 930):

    BQ063321 AF498948 BE561212 BE790802 BU859923 AI189370 BC009227 BM473477 
    BQ433369 BQ051606 AI384079 BM831782 BM820800 BM685130 CA942890 AI380000 
    BE047730 CA416627 AA683473 AA701486 CR618181 AI040681 BQ949163 C00883 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JTB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTCATCT
    JTB Expression
    About this image


    JTB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    JTB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JTB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6396

    UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
    Tissue specificity: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed
    in many of their malignant counterparts

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for JTB gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jtb1 , 5 jumping translocation breakpoint1, 5 82.88(n)1
    85.62(a)1
      3 (39.21 cM)5
    239221  NM_206924.21  NP_996807.11 
     902315975 
    chicken
    (Gallus gallus)
    Aves JTB6
    jumping translocation breakpoint
    67(a)
    1 ↔ 1
    AADN03010944.1(38-906)
    zebrafish
    (Danio rerio)
    Actinopterygii jtb6
    jumping translocation breakpoint
    24(a)
    1 ↔ 1
    19(43748161-43756946) ENSDARG00000070150


    ENSEMBL Gene Tree for JTB (if available)
    TreeFam Gene Tree for JTB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JTB gene

    JTB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for JTB
    PGOHUM00000246593


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JTB (see all 100)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2015819581,2
    C--153947355(+) AGACAC/GCTTCT 1 -- int10--------
    rs1507719801,2
    C--153947463(+) AAATAC/GATCAT 1 -- int10--------
    rs1393659911,2
    --153947743(+) AGGTGC/TCCGCC 1 -- int10--------
    rs1816722761,2
    C--153947842(+) CACCCA/GCCTCG 1 -- int10--------
    rs1859677641,2
    --153947980(+) TCTAAA/CCTCTG 1 -- int10--------
    rs1426534741,2
    C--153948000(+) TTCAAC/GTGATT 1 -- int10--------
    rs1912284581,2
    --153948097(+) CACCAC/TGTTGG 1 -- int10--------
    rs75279631,2
    C,F,H--153948221(+) CCCCAA/G/TACCAG 1 -- int16NS EA NA 496
    rs1433276741,2
    C,F--153948338(+) ATGTGA/CTTTTC 2 S I mis12Minor allele frequency- C:0.00NA EU 5869
    rs1463923901,2
    C,F--153948363(+) GGGACC/TACACT 2 S G mis11Minor allele frequency- T:0.00NA 4550

    HapMap Linkage Disequilibrium report for JTB (153946745 - 153950451 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for JTB: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JTB
    DNA2.0 Custom Variant and Variant Library Synthesis for JTB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604671    OMIM disorders: --

    11 diseases for JTB:    
    About MalaCards
    abdominal tuberculosis    lymph node tuberculosis    tuberculous meningitis    prostatitis
    tuberculosis    meningitis    tonsillitis    hepatocellular carcinoma
    thyroiditis    cerebritis    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for JTB:
    Lymph node tuberculosis

    JTB for disorders           About GeneDecksing


    Export disorders for JTB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JTB gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with JTB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. (PubMed id 10321732)1, 2, 3 Hatakeyama S.... Ishikawa F. (Oncogene 1999)
    2. The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold. (PubMed id 22079049)1, 2 Rousseau F.... Lingel A. (J. Mol. Biol. 2012)
    3. PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins. (PubMed id 21225229)1, 2 Platica M.... Platica O. (Int. J. Oncol. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells. (PubMed id 10762645)1, 2 Platica O.... Platica M. (Int. J. Oncol. 2000)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. [Downregulation of PAR expression induces the apoptosis of human prostate cancer PC3 cells and increases the Bcl-2/Bax ratio]. (PubMed id 23297497)1 Xu X.F....Gao J.P. (Zhonghua Nan Ke Xue 2012)
    8. HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. (PubMed id 22615844)1 Liu Y.P....Ren J.L. (PLoS ONE 2012)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10899 HGNC: 6201 AceView: RAB13andJTB Ensembl:ENSG00000143543 euGenes: HUgn10899
    ECgene: JTB H-InvDB: JTB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JTB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JTB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JTB gene:
    Search GeneIP for patents involving JTB

    GeneCards and IP:
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