V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

JTB Gene

protein-coding   GIFtS: 56

GC01M152213
jumping translocation breakpoint
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
HJTB 2
HSPC222 2
OTTHUMP00000034759 2
PAR 2, 5
hJT 1, 2
Descriptions
Jumping translocation breakpoint protein 3
PAR protein 3
Prostate androgen-regulated protein 3
jumping translocation breakpoint 2
prostate androgen-regulated 2
External Ids
HGNC: 62011
Entrez Gene: 108992
UniProtKB: O760953
Ensembl: ENSG000001435437
Search outside databases for aliases for JTB gene

Previous GC identifers: GC01M151763 GC01M149677 GC01M150722 GC01M151163 GC01M150759

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for JTB
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the JTB gene  

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

JTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M152213:     (about GC identifiers)

Start:
152,213,369 bp from pter
End:
152,217,075 bp from pter
Size:
3,707 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095 (See protein sequence)
Recommended Name: Protein JTB precursor  
Size: 146 amino acids; 16358 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: O95442

REFSEQ proteins: NP_006685.1  

ENSEMBL proteins: 
ENSP00000271843 ENSP00000349069 ENSP00000357578 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (JTB)
Human Recombinant Proteins from Abnova (JTB)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005624 membrane fraction TAS10321732
GO:0005856 cytoskeleton IDA18029348
GO:0005887 integral to plasma membrane TAS10321732
GO:0016020 membrane IEA--
GO:0043231 intracellular membrane-bounded organelle IDA18029348
About this table

Antibodies for JTB: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for JTB
Browse R&D Systems for Antibodies
Antibodies from Abcam (JTB), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (JTB)
Novus Biologicals Antibodies for JTB

Assays for JTB: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR008657 JTB


   GeneDecks  JTB for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O76095

ProtoNet protein and cluster: O76095

1 Blocks protein family: IPB008657 Jumping translocation breakpoint

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
Similarity: Belongs to the JTB family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (JTB)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (JTB)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006694

              Applied Biosystems Silencer® siRNAs for JTB

              Sigma-Aldrich siRNA for JTB  
                     Sigma-Aldrich shRNA for JTB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for JTB
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006694
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006694
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006694 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006694

Genatlas biochemistry entry for JTB:
jumping translocation breakpoint,fused with the telomeric repeats case of jumping translocation
(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for JTB (ENSP000002718433) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
HRASENSP000003733823STRING (score=.715)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JTB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (JTB)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (JTB)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006694

              Sigma-Aldrich siRNA for JTB  
                     Sigma-Aldrich shRNA for JTB  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006694  

REFSEQ mRNAs for JTB gene: 

NM_006694.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006694  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006694
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006694
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006694 

Additional cDNA sequence: 

AB016488.1 AF115850.2 AF131797.1 AF151056.1 AK312106.1 BC000499.1 BC000996.2 BC001363.1 
BC001667.1 BC004239.1 BC019277.1 BT007285.1 CR456985.1 CR595312.1 CR599832.1 CR603308.1 
CR608719.1 CR613105.1 CR618181.1 CR620505.1 CR625103.1 

24/26 DOTS entries (see all 26 ):

DT.421099  DT.75133749  DT.75130019  DT.100817421  DT.100817416  DT.97844584  DT.95277027  DT.121436598 
DT.92453787  DT.95277035  DT.121436576  DT.121436568  DT.100039009  DT.95277024  DT.100817411  DT.100817420 
DT.92453774  DT.95155142  DT.95104852  DT.97844583  DT.121436377  DT.92453775  DT.95277026  DT.95277029 

24/930 AceView cDNA sequences (see all 930 ):

AI189370 BC001667 AI040681 AI083503 BU196184 BQ955026 AI568647 AA831877 
BE890968 CB143317 AI090977 BE396510 BC000996 CR625103 AA583766 BQ417123 
CB148747 AF498948 BM828283 AA701486 AI581804 CA503023 AW070310 BC019277 

highest scoring ESTs for JTB:

AA147827 AA186580 AA278716 AA312833 AA313810 AA324649 AA384595 AA403075 AA424759 AA478159 

Unigene Cluster for JTB:

Jumping translocation breakpoint
Hs.6396  [show with all ESTs]
Unigene Representative Sequence: BQ062593


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000271843  ENST00000356648  ENST00000368589  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JTB expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for JTB

1 / 2 / 3

10 probe-sets matching JTB gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

41833_at2, 3 U95-A 1 1.00 1.00 0.65 1.13 AB016492 0.20 1.00 0.72 1

59797_f_at2, 3 U95-C 1 1.00 1.00 0.71 1.15 AW025321 0.80 0.70 0.75 1
59798_r_at2, 3 U95-C 1 1.00 1.00 0.62 0.75 AW025321 0.80 0.70 0.75 1

41834_g_at2, 3 U95-A 1 1.00 1.00 0.76 0.97 AB016492 0.20 1.00 0.72 1

200048_s_at2, 3 U133-B 1 1.00 1.00 -- -- NM_006694 0.60 0.83 0.73 1

210927_x_at2, 3 U133-A 1 1.00 1.00 -- -- BC004239 0.80 0.88 0.84 1

210434_x_at2, 3 U133-A 1 1.00 1.00 -- -- AF151056 0.80 0.88 0.84 1

200048_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

210927_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

210434_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  JTB for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CAGCTCATCT

SOURCE GeneReport for Unigene cluster: Hs.6396

Expression variation in blood from EXPOLDB for JTB

UniProtKB/Swiss-Prot: JTB_HUMAN, O76095
Tissue specificity: Expressed in all normal human tissues studied but overexpressed in most of
their malignant counterparts

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for JTB gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
JTB1   -- jumping translocation breakpoint 86.53(n)
87.67(a)
612300  XM_850043.1  XP_855136.1 
chimpanzee
(Pan troglodytes)
JTB1   -- jumping translocation breakpoint 99.54(n)
100(a)
457342  XM_001149478.1  XP_001149478.1 
cow
(Bos taurus)
JTB1   -- jumping translocation breakpoint 89.95(n)
89.73(a)
513970  XM_591741.3  XP_591741.1 
rat
(Rattus norvegicus)
Jtb1   -- jumping translocation breakpoint 84.02(n)
86.99(a)
29439  NM_019213.2  NP_062086.1 
mouse
(Mus musculus)
Jtb1, 5 35
jumping translocation breakpoint1, 5 82.88(n)1
85.62(a)1
239221  NM_206924.21  NP_996807.11 
 AB0164905  AK0044695  (see all 12)
About this table        Species with no ortholog for JTB

ENSEMBL Gene Tree for JTB
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/16 NCBI SNPs in JTB are shown (see all 16 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 20)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs346862441,2
F152216307(-) GCCACC/TTCTGC 1 L/F mis11Minor allele frequency- T:0.03NA 58
rs125641991,2
C,F,H152215164(+) GTGGTG/AGTTGC 1 -- int16Minor allele frequency- A:0.17EU EA WA NA 596
rs115810391,2
C,H152215214(+) GTCTAG/AGAGTG 1 -- int14Minor allele frequency- A:0.00EU EA WA 418
--
rs112647631,2
A,C152215329(+) gaggcC/Tgaggc 1 -- int10--------
rs75279631,2
H152214845(+) CCCCAG/AACCAG 1 -- int14Minor allele frequency- A:0.00EU EA WA 416
--
rs15477671,2
--152218844(+) AATTAC/TATATA 1 -- ng310--------
--
rs15477661,2
--152218829(+) TATTAA/CACATA 1 -- ng31 tfbs30--------
--
rs115432751,2
--152216565(-) CGCCTA/CCCTAG 1 -- ut51 ese30--------
rs31829461,2
--152216714(-) ACCGGG/CCCCCG 1 -- ut51 ese31Minor allele frequency- C:0.00MN 184
--
rs115432761,2
--152215851(-) ATGCTG/TGGCTG 2 W/V W/L fra10--------
About this table

HapMap Linkage Disequilibrium images for JTB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604671

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/11 PubMed articles for JTB gene (see all 11 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10899 HGNC: 6201 AceView: RAB13andJTB Ensembl:ENSG00000143543 euGenes: HUgn10899
ECgene: JTB H-InvDB: JTB
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for JTB Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for JTB:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for JTB-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for JTB Antibodies for JTB
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for JTB Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (JTB)
 Antibodies (JTB)
 Chimera RNAi (JTB)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(JTB)
 Antibodies (JTB)
 Search OriGene for JTB
 Search Tocris compounds for JTB




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for JTB

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
JTB Gene at Home site.
Version 2.41.1
server5.xennexinc.com