Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JSRP1 Gene

protein-coding   GIFtS: 46
GCID: GC19M002252

Junctional Sarcoplasmic Reticulum Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Junctional Sarcoplasmic Reticulum Protein 11 2     JP452 3
Homolog Of Mouse Skeletal Muscle Sarcoplasmic Reticulum Protein JP-451 2     2310032K21Rik2
Junctional-Face Membrane Protein Of 45 KDa Homolog2 3     Skeletal Muscle Sarcoplasmic Reticulum Protein JP-452
JP-452 3     

External Ids:    HGNC: 249631   Entrez Gene: 1263062   Ensembl: ENSG000001674767   OMIM: 6087435   UniProtKB: Q96MG23   

Export aliases for JSRP1 gene to outside databases

Previous GC identifers: GC19M002204 GC19M002205 GC19M002025


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JSRP1 Gene:
The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The
encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux
in skeletal muscle. (provided by RefSeq, Jul 2012)

GeneCards Summary for JSRP1 Gene: 
JSRP1 (junctional sarcoplasmic reticulum protein 1) is a protein-coding gene. Diseases associated with JSRP1 include malignant hyperthermia, and graves' disease.

UniProtKB/Swiss-Prot: JSPR1_HUMAN, Q96MG2
Function: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the
voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal
(depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening
of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JSRP1 gene promoter:
         Spz1   SREBP-1a   p53   SREBP-1c   MyoD   STAT5A   Zic3   SREBP-1b   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJSRP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for JSRP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JSRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

JSRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JSRP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M002252:  view genomic region     (about GC identifiers)

Start:
2,252,250 bp from pter      End:
2,269,758 bp from pter
Size:
17,509 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JSPR1_HUMAN, Q96MG2 (See protein sequence)
Recommended Name: Junctional sarcoplasmic reticulum protein 1  
Size: 331 amino acids; 36319 Da
Subunit: Interacts with CACNA1S, CACNB1 and calsequestrin (By similarity)
Subcellular location: Sarcoplasmic reticulum membrane (By similarity). Endoplasmic reticulum membrane (By
similarity). Note=Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes (By
similarity)
Caution: It is uncertain whether Met-1 or Met-3 is the initiator

Explore the universe of human proteins at neXtProt for JSRP1: NX_Q96MG2

Explore proteomics data for JSRP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96MG2

  • JSRP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JSRP1 Protein Expression
    REFSEQ proteins: NP_653217.1  
    ENSEMBL proteins: 
     ENSP00000468418   ENSP00000300961   ENSP00000465604  

    Human Recombinant Protein Products for JSRP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for JSRP1
    GenScript Custom Purified and Recombinant Proteins Services for JSRP1
    Novus Biologicals JSRP1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JSRP1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033017sarcoplasmic reticulum membrane IEA--

    JSRP1 for ontologies           About GeneDecksing



    JSRP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for JSRP1
    GenScript Custom Superior Antibodies Services for JSRP1
    Novus Biologicals JSRP1 Antibodies
    Search for Antibodies for JSRP1 at Abcam
    Cloud-Clone Corp. Antibodies for JSRP1 
    Search ThermoFisher Antibodies for JSRP1
    Search LSBio for Antibodies for JSRP1 

    Assay Products for JSRP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for JSRP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JSRP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JSRP1 
    Cloud-Clone Corp. CLIAs for JSRP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026178 JSRP1

    Graphical View of Domain Structure for InterPro Entry Q96MG2

    ProtoNet protein and cluster: Q96MG2


    JSRP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JSPR1_HUMAN, Q96MG2
    Function: Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the
    voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal
    (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening
    of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity

    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jsrp1):

     homeostasis/metabolism  muscle 

    JSRP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Jsrp1tm1Zor for JSRP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for JSRP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JSRP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JSRP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JSRP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JSRP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate JSRP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for JSRP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JSRP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JSRP1
    Sirion Biotech Customized adenovirus for overexpression of JSRP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for JSRP1 (see all 5)
    OriGene ORF clones in mouse, rat for JSRP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JSRP1 (NM_144616)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JSRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JSRP1
    Sirion Biotech Customized lentivirus for stable overexpression of JSRP1 
                         Customized lentivirus expression plasmids for stable overexpression of JSRP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JSRP1
    Search LifeMap BioReagents cell lines for JSRP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JSRP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JSRP1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for JSRP1 (ENSP000003009614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TERF1ENSP000002766034STRING: ENSP00000276603
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003009skeletal muscle contraction IDA--

    JSRP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JSRP1 (JSPR1)

    1 HMDB Compound for JSRP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about JSRP1 / JSPR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JSRP1 gene: 
    NM_144616.3  

    Unigene Cluster for JSRP1:

    Junctional sarcoplasmic reticulum protein 1
    Hs.330742  [show with all ESTs]
    Unigene Representative Sequence: BM464867
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000586471 ENST00000300961(uc002lvj.2) ENST00000593238 ENST00000590976

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JSRP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate JSRP1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for JSRP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JSRP1
    Clone
    Products:
         
    OriGene clones in human, mouse for JSRP1 (see all 5)
    OriGene ORF clones in mouse, rat for JSRP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JSRP1 (NM_144616)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JSRP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JSRP1
    Sirion Biotech Customized lentivirus for stable overexpression of JSRP1 
                         Customized lentivirus expression plasmids for stable overexpression of JSRP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for JSRP1
    OriGene qSTAR qPCR primer pairs in human, mouse for JSRP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JSRP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JSRP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JSRP1

    Additional mRNA sequence: 

    AK056978.1 BC021201.2 

    21 DOTS entries:

    DT.91753476  DT.97774110  DT.100881247  DT.100881250  DT.101958942  DT.121414371  DT.100039595  DT.454368 
    DT.91999328  DT.91999868  DT.95338347  DT.97793139  DT.100881245  DT.101985580  DT.121414420  DT.121414664 
    DT.100881253  DT.100881254  DT.121414845  DT.95338331  DT.95338340 

    24/25 AceView cDNA sequences (see all 25):

    AK056978 AW137573 BC021201 BE503611 BQ685035 F27540 NM_144616 BE746917 
    BI827484 AI825241 BE743731 AW000792 AA688087 BM474204 BG827814 F34204 
    BF204446 AI805145 AA628755 F35910 BG827699 AI298723 AA523549 BF306204 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JSRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACCAGAG
    JSRP1 Expression
    About this image


    See JSRP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JSRP1

    SOURCE GeneReport for Unigene cluster: Hs.330742
        SABiosciences Custom PCR Arrays for JSRP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for JSRP1
    OriGene qSTAR qPCR primer pairs in human, mouse for JSRP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JSRP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JSRP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JSRP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JSRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for JSRP1 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jsrp11 , 5 junctional sarcoplasmic reticulum protein 11, 5 69.54(n)1
    57.19(a)1
      10 (39.72 cM)5
    719121  NM_028001.31  NP_082277.21 
     808084985 
    chicken
    (Gallus gallus)
    Aves JSRP16
    Uncharacterized protein
    25(a)
    1 ↔ 1
    28(1954074-1955458)


    ENSEMBL Gene Tree for JSRP1 (if available)
    TreeFam Gene Tree for JSRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 SNPs in JSRP1 are shown (see all 181)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104176281,2
    C,F,H--2178800(+) GCAGGC/TCCGTG 1 -- ds500111Minor allele frequency- T:0.02NA CSA WA EA EU 3924
    rs1445134241,2
    C--2178808(+) GTGGGG/ACCGCC 1 -- ds50011Minor allele frequency- A:0.00NA 2548
    rs2000311511,2
    C--2178812(+) GGCCGC/TCCTGG 1 -- ds50010--------
    rs1497023091,2
    C--2178819(+) CTGGCG/TCGCCC 1 -- ds50010--------
    rs1454427471,2
    --2179033(+) CCCCAA/GTAAAG 1 -- ds50010--------
    rs2001633731,2
    --2179297(+) ACTCCC/GGCGCG 1 -- ut310--------
    rs778178181,2
    C--2179443(+) GGCCGA/GTGGCC 2 H syn10--------
    rs2014097981,2
    --2179482(+) AGGGCC/TTCCCG 2 E syn10--------
    rs1505778171,2
    C,F--2179508(+) CCGTGG/ACCTCT 2 /P /S mis11Minor allele frequency- A:0.00NA 4184
    rs2004868291,2
    --2179514(+) CCTCTA/CCTCTT 2 E * stg10--------

    HapMap Linkage Disequilibrium report for JSRP1 (2252250 - 2269758 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for JSRP1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3634n71CNV Loss21882294
    dgv3631n71CNV Loss21882294
    dgv3630n71CNV Loss21882294
    dgv3614n71CNV Loss21882294
    dgv3629n71CNV Loss21882294
    nsv910499CNV Loss21882294
    dgv3632n71CNV Loss21882294
    dgv3626n71CNV Loss21882294
    dgv3622n71CNV Loss21882294
    nsv910643CNV Loss21882294


    Human Gene Mutation Database (HGMD): JSRP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing JSRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for JSRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608743    OMIM disorders: --

    2 diseases for JSRP1:    About MalaCards
    malignant hyperthermia    graves' disease

    1 disease from the University of Copenhagen DISEASES database for JSRP1:
    Malignant hyperthermia

    JSRP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): JSRP1
    Human Genome Epidemiology (HuGE) Navigator: JSRP1 (1 document)

    Export disorders for JSRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JSRP1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with JSRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. (PubMed id 12871958)1, 3, 9 Anderson A.A....Zorzato F. (2003)
    2. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. (PubMed id 22927026)1, 2 Yasuda T.... Zorzato F. (2013)
    3. Follow-up of potential novel Graves' disease suscepti bility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study. (PubMed id 20442750)1, 4 Newby P.R....Gough S.C. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A possible role of the junctional face protein JP-45 in modulating Ca2+ release in skeletal muscle. (PubMed id 16423849)1, 9 Gouadon E....Melzer W. (2006)
    6. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. (PubMed id 18077436)9 Delbono O....Zorzato F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126306 HGNC: 24963 AceView: FLJ32416 Ensembl:ENSG00000167476 euGenes: HUgn126306
    ECgene: JSRP1 H-InvDB: JSRP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JSRP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JSRP1 gene:
    Search GeneIP for patents involving JSRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for JSRP1  
     OriGene qPCR primer pairs and template standards for JSRP1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for JSRP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for JSRP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for JSRP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for JSRP1   OriGene Custom Protein Services for JSRP1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JSRP1
     QIAGEN SeqTarget long-range PCR primers for resequencing JSRP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JSRP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JSRP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JSRP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JSRP1
     GenScript Custom Purified and Recombinant Proteins Services for JSRP1 GenScript cDNA clones with any tag delivered in your preferred vector for JSRP1
     GenScript Custom Assay Services for JSRP1 GenScript Custom Superior Antibodies Services for JSRP1
     GenScript Custom overexpressing Cell Line Services for JSRP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in JSRP1 promoter
     Search Chromatin IP Primers for JSRP1
     RT2 qPCR Primer Assay in human, mouse, rat JSRP1
     Search GNC Networks for JSRP1
     SABiosciences Custom PCR Arrays for JSRP1
     Search Tocris compounds for JSRP1 (JSPR1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     JSRP1 antibodies
     JSRP1 proteins
     Search for Antibodies for JSRP1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for JSRP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for JSRP1
     Antibodies for JSRP1
     ELISAs for JSRP1
     CLIAs for JSRP1
     Search LifeMap BioReagents cell lines for JSRP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JSRP1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for JSRP1
     SwitchGear Promoter luciferase reporter plasmids for JSRP1
     Search ThermoFisher Antibodies for JSRP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JSRP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for JSRP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JSRP1
    Customized:
     lentivirus for stable overexpression of JSRP1
     lentivirus expression plasmids for stable overexpression of JSRP1
     adenovirus for overexpression of JSRP1
     Search LSBio for Antibodies for JSRP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      JSRP1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4