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JRKL Gene

protein-coding GIFtS: 51

GC11P095763

jerky homolog-like (mouse)
(Previous name: erky (mouse) homolog-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HHMJG ^¹, ², ³, ⁵
MGC129608 ^²

Descriptions
erky (mouse) homolog-like ^¹
erky homolog-like ^²
jerky homolog-like ^²
jerky homolog-like (mouse) ^²

External Ids
HGNC: 6200¹
Entrez Gene: 8690²
UniProtKB: Q9Y4A0³
Ensembl: ENSG00000183340⁷

Search outside databases for aliases for JRKL gene

Previous GC identifers: GC11P098454 GC11P097631 GC11P096308 GC11P095811

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for JRKL:

The function of this gene has not yet been defined, however, the encoded protein shares similarity

with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act

as a nuclear regulatory protein. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the JRKL gene

Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21

JRKL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P095763: (about GC identifiers)

Start:	95,762,806 bp from pter
End:	95,766,375 bp from pter
Size:	3,570 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_008984.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0 (See protein sequence)

Recommended Name: Jerky protein homolog-like

Size: 442 amino acids; 50710 Da

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003763.2

ENSEMBL proteins:

ENSP00000333350

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (JRKL)
	Human Recombinant Proteins from Abnova (JRKL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9240447

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Antibodies for JRKL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for JRKL
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (JRKL), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JRKL)
	Novus Biologicals Antibodies for JRKL

Assays for JRKL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y4A0

ProtoNet protein and cluster: Q9Y4A0

1 Blocks protein family: IPB004875 CENP-B protein

UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0

Similarity: Belongs to the tigger transposable element derived protein family

Similarity: Contains 1 DDE domain

Similarity: Contains 1 HTH CENPB-type DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JRKL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JRKL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003772

Applied Biosystems Silencer® siRNAs for JRKL

Sigma-Aldrich siRNA for JRKL

Sigma-Aldrich shRNA for JRKL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003772
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003772
untagged cDNA clone in CMV expression vector: NM_003772

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003772

Genatlas biochemistry entry for JRKL:

murine jerky homolog-like,involved in epileptic syndromes in mice,expressed in many tissues,with

two alternatively forms in testis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007417	central nervous system development	TAS	9240447
GO:0045449	regulation of transcription	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JRKL
2 PharmGKB drug compound relationships for JRKL gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JRKL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JRKL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003772

Sigma-Aldrich siRNA for JRKL

Sigma-Aldrich shRNA for JRKL

Explore Sigma-Aldrich super-pooled esiRNAs

REFSEQ mRNAs for JRKL gene:

NM_003772.3

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003772
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003772
                                 untagged cDNA clone in CMV expression vector: NM_003772

Additional cDNA sequence:

AF004715.1 AK290579.1 AK314216.1 BC031306.1 BC109202.2

2 DOTS entries:

DT.404002 DT.99932675

21 AceView cDNA sequences:

CA503357 NM_003772 AI985103 BU633595 BM468034 AA991350 BG926401 BQ719793

AF004715 AW662715 BG403784 BX472885 BX089945 CA448235 AI733607 AI792197

BP334207 BG926222 BF242601 AW151655 BU588099

highest scoring ESTs for JRKL:

AF004715 AA991350 AI733607 AI792197 AI985103 AW662715 BF242601 BG403784 BM468034 BM894432

Unigene Cluster for JRKL:

Jerky homolog-like (mouse)

Hs.105940 [show with all ESTs]

Unigene Representative Sequence: NM_003772

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000332349

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JRKL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JRKL

¹ / ² / ³

4 probe-sets matching JRKL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35074_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF004715	1.00	1.00	1.00	1
206734_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003772	0.60	1.00	0.82	1
206734_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1557790_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.105940
Expression variation in blood from EXPOLDB for JRKL
UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0
Tissue specificity: Abundantly expressed in the majority of tissues examined, including brain and
skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JRKL gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JRKL¹	--	jerky homolog-like (mouse)	91.03(n) 95.61(a)	476764 XM_533970.2 XP_533970.1
cow (Bos taurus)	JRKL¹	--	jerky homolog-like (mouse)	92.37(n) 94.85(a)	539736 XM_589056.3 XP_589056.1
rat (Rattus norvegicus)	Jrkl¹	--	jerky homolog-like (mouse)	88.93(n) 93.32(a)	315417 XM_235818.4 XP_235818.2
mouse (Mus musculus)	Jrkl^{1, 5}	--⁵	jerky homolog-like (mouse)^{1, 5}	89.8(n)¹ 94.07(a)¹	77532¹ XM_001472472.1¹ XP_001472522.1¹ AK021123⁵ AK079877⁵ (see all 8)
African malaria mosquito (Anopheles gambiae)	AgaP_AGAP003894¹	--	AGAP003894-PA	48.52(n) 39.92(a)	1269486 XM_308124.2 XP_308124.2

About this table Species with no ortholog for JRKL

ENSEMBL Gene Tree for JRKL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JRKL gene

TIGD7² TIGD2² TIGD5² CENPB² TIGD3² TIGD6² TIGD4² ENSG00000221944²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/14 NCBI SNPs in JRKL are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 30)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4753751^1,2	A,C,F,H	95766009(+)	`TTGTCA/GTATCT`	1	--	ut3¹		10		EA NA EU WA	818
	rs11021573^1,2	F,H	95766188(+)	`GCTAAA/TATGTA`	1	--	ut3¹		4		EU EA WA	418
	rs4753750^1,2	A,H	95765570(+)	`TGCCTT/CCATTC`	1	--	ut3¹		4		EU EA WA	416
--	rs11021572^1,2	H	95765960(+)	`taGTGT/GTTTTA`	1	--	ut3¹		4		EU EA WA	416
--	rs3133505^1,2	H	95766289(+)	`TACCTT/GGTAAT`	1	--	ut3¹		4		EU EA WA	404
	rs1053028^1,2	F	95765801(+)	`TTTTTA/TTTATG`	1	--	ut3¹		1		MN	184
	rs3098654^1,2	H	95766311(-)	`CATGGA/GAACAC`	1	--	ut3¹		4		EU EA WA	420
	rs3133506^1,2	H	95766330(+)	`TGTTTT/GGGCCa`	1	--	ut3¹		4		EU EA WA	408
--	rs11021571^1,2	--	95765958(+)	`tttaGG/TGTTTT`	1	--	ut3¹		0	--	--	--	--
	rs11549459^1,2	--	95765813(+)	`ATTTGG/TTAATA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for JRKL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603211

1 PharmGKB disease relationship for JRKL gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12704389

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for JRKL gene:

Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product. (PubMed id 9240447)^{2, 3, 4} Zeng Z.... Li Y. (1997)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. (PubMed id 12704389)⁷ Cheok M.H....Evans W.E. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8690	HGNC: 6200	AceView: JRKL	Ensembl:ENSG00000183340	euGenes: HUgn8690
ECgene: JRKL	H-InvDB: JRKL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for JRKL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for JRKL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JRKL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JRKL		Antibodies for JRKL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for JRKL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for JRKL

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JRKL Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for JRKL

Summaries
for JRKL

Genomic Location
for JRKL

Proteins
for JRKL

Protein Domains/
Families
for JRKL

Gene Function
for JRKL

Pathways & Interactions
for JRKL

Drugs & Compounds
for JRKL

Transcripts
for JRKL

Expression
for JRKL

Orthologs
for JRKL

Paralogs
for JRKL

SNPs/Variants
for JRKL

Disorders & Mutations
for JRKL

Medical News
for JRKL

Publications
for JRKL

Search for JRKL

Genome Databases showing JRKL

Other Databases showing JRKL

Specialized Databases showing JRKL

Licensable Technologies
for JRKL

Services
for JRKL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JRKL Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor JRKL

Summariesfor JRKL

Genomic Locationfor JRKL

Proteinsfor JRKL

Protein Domains/Familiesfor JRKL

Gene Functionfor JRKL

Pathways & Interactionsfor JRKL

Drugs & Compoundsfor JRKL

Transcriptsfor JRKL

Expression for JRKL

Orthologsfor JRKL

Paralogsfor JRKL

SNPs/Variantsfor JRKL

Disorders & Mutationsfor JRKL

Medical Newsfor JRKL

Publicationsfor JRKL

Search for JRKL

Genome Databases showing JRKL

Other Databases showing JRKL

Specialized Databases showing JRKL

Licensable Technologiesfor JRKL

Servicesfor JRKL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JRKL

Summaries
for JRKL

Genomic Location
for JRKL

Proteins
for JRKL

Protein Domains/
Families
for JRKL

Gene Function
for JRKL

Pathways & Interactions
for JRKL

Drugs & Compounds
for JRKL

Transcripts
for JRKL

Expression
for JRKL

Orthologs
for JRKL

Paralogs
for JRKL

SNPs/Variants
for JRKL

Disorders & Mutations
for JRKL

Medical News
for JRKL

Publications
for JRKL

Licensable Technologies
for JRKL

Services
for JRKL