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Aliases for JRKL Gene

Aliases for JRKL Gene

  • JRK-Like 2 3
  • Human Homolog Of Mouse Jerky Gene Protein 3 4
  • HHMJG 3 4
  • Jerky Homolog-Like (Mouse) 2
  • Erky (Mouse) Homolog-Like 2

External Ids for JRKL Gene

Previous GeneCards Identifiers for JRKL Gene

  • GC11P098454
  • GC11P097631
  • GC11P096308
  • GC11P095811
  • GC11P095763
  • GC11P096123
  • GC11P092189

Summaries for JRKL Gene

Entrez Gene Summary for JRKL Gene

  • The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for JRKL Gene

JRKL (JRK-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD5.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JRKL Gene

Genomics for JRKL Gene

Regulatory Elements for JRKL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for JRKL Gene

Chromosome:
11
Start:
96,389,989 bp from pter
End:
96,507,574 bp from pter
Size:
117,586 bases
Orientation:
Plus strand

Genomic View for JRKL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JRKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JRKL Gene

Proteins for JRKL Gene

  • Protein details for JRKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A0-JERKL_HUMAN
    Recommended name:
    Jerky protein homolog-like
    Protein Accession:
    Q9Y4A0
    Secondary Accessions:
    • A8K3G4
    • B2RAJ3
    • Q32MC2

    Protein attributes for JRKL Gene

    Size:
    524 amino acids
    Molecular mass:
    59912 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB65833.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for JRKL Gene

Proteomics data for JRKL Gene at MOPED

Post-translational modifications for JRKL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JRKL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JRKL Gene

Domains & Families for JRKL Gene

Gene Families for JRKL Gene

Protein Domains for JRKL Gene

Suggested Antigen Peptide Sequences for JRKL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4A0

UniProtKB/Swiss-Prot:

JERKL_HUMAN :
  • Contains 1 DDE domain.
  • Belongs to the tigger transposable element derived protein family.
Domain:
  • Contains 1 DDE domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
Family:
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with JRKL: view

Function for JRKL Gene

Molecular function for JRKL Gene

GENATLAS Biochemistry:
murine jerky homolog-like,involved in epileptic syndromes in mice,expressed in many tissues,with two alternatively forms in testis

Gene Ontology (GO) - Molecular Function for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with JRKL: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JRKL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for JRKL Gene

Localization for JRKL Gene

Subcellular locations from UniProtKB/Swiss-Prot for JRKL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JRKL Gene COMPARTMENTS Subcellular localization image for JRKL gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with JRKL: view

Pathways & Interactions for JRKL Gene

SuperPathways for JRKL Gene

No Data Available

Interacting Proteins for JRKL Gene

Gene Ontology (GO) - Biological Process for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 9240447
genes like me logo Genes that share ontologies with JRKL: view

No data available for Pathways by source and SIGNOR curated interactions for JRKL Gene

Drugs & Compounds for JRKL Gene

No Compound Related Data Available

Transcripts for JRKL Gene

mRNA/cDNA for JRKL Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JRKL Gene

Jerky homolog-like (mouse):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JRKL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JRKL Gene

No ASD Table

Relevant External Links for JRKL Gene

GeneLoc Exon Structure for
JRKL
ECgene alternative splicing isoforms for
JRKL

Expression for JRKL Gene

mRNA expression in normal human tissues for JRKL Gene

Protein differential expression in normal tissues from HIPED for JRKL Gene

This gene is overexpressed in Heart (58.1) and Retina (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for JRKL Gene



SOURCE GeneReport for Unigene cluster for JRKL Gene Hs.105940

mRNA Expression by UniProt/SwissProt for JRKL Gene

Q9Y4A0-JERKL_HUMAN
Tissue specificity: Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle
genes like me logo Genes that share expression patterns with JRKL: view

Protein tissue co-expression partners for JRKL Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for JRKL Gene

Orthologs for JRKL Gene

This gene was present in the common ancestor of chordates.

Orthologs for JRKL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia JRKL 35
  • 92.37 (n)
  • 94.85 (a)
JRKL 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JRKL 35
  • 91.03 (n)
  • 95.61 (a)
JRKL 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jrkl 35
  • 89.8 (n)
  • 94.07 (a)
Jrkl 16
Jrkl 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia JRKL 35
  • 99.87 (n)
  • 99.81 (a)
rat
(Rattus norvegicus)
Mammalia Jrkl 35
  • 88.93 (n)
  • 93.32 (a)
oppossum
(Monodelphis domestica)
Mammalia JRKL 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
ManyToMany
Species with no ortholog for JRKL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JRKL Gene

ENSEMBL:
Gene Tree for JRKL (if available)
TreeFam:
Gene Tree for JRKL (if available)

Paralogs for JRKL Gene

Paralogs for JRKL Gene

(4) SIMAP similar genes for JRKL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JRKL: view

Variants for JRKL Gene

Sequence variations from dbSNP and Humsavar for JRKL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1053028 -- 96,392,989(+) TTTTT(A/C/T)TTATG utr-variant-3-prime
rs3098654 -- 96,393,499(-) CATGG(A/G)AACAC utr-variant-3-prime
rs3098655 -- 96,393,474(-) ACAAG(G/T)TACAT utr-variant-3-prime
rs3133505 -- 96,393,477(+) TACCT(G/T)GTAAT utr-variant-3-prime
rs3133506 -- 96,393,518(+) TGTTT(G/T)GGCCa utr-variant-3-prime

Variation tolerance for JRKL Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JRKL Gene

HapMap Linkage Disequilibrium report
JRKL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JRKL Gene

Disorders for JRKL Gene

Relevant External Links for JRKL

Genetic Association Database (GAD)
JRKL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JRKL
genes like me logo Genes that share disorders with JRKL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JRKL Gene

Publications for JRKL Gene

  1. Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product. (PMID: 9240447) Zeng Z. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 67
  2. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. (PMID: 22648509) Wang K.S. … Zeng M. (J. Mol. Neurosci. 2012) 67
  3. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 67
  4. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 67
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 67

Products for JRKL Gene

Sources for JRKL Gene

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