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Aliases for JRKL Gene

Aliases for JRKL Gene

  • JRK-Like 2 3 5
  • Human Homolog Of Mouse Jerky Gene Protein 3 4
  • HHMJG 3 4
  • Jerky Homolog-Like (Mouse) 2
  • Jerky Protein Homolog-Like 3
  • Erky (Mouse) Homolog-Like 2

External Ids for JRKL Gene

Previous GeneCards Identifiers for JRKL Gene

  • GC11P098454
  • GC11P097631
  • GC11P096308
  • GC11P095811
  • GC11P095763
  • GC11P096123
  • GC11P092189

Summaries for JRKL Gene

Entrez Gene Summary for JRKL Gene

  • The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for JRKL Gene

JRKL (JRK-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is TIGD2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JRKL Gene

Genomics for JRKL Gene

Regulatory Elements for JRKL Gene

Enhancers for JRKL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F095788 1.2 ENCODE 11 -599.6 -599573 4.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 CEP57 JRKL LOC101929295 MTMR2 FAM76B GC11M095802
GH11F095697 1 Ensembl ENCODE 11.6 -690.6 -690639 3.8 HDGF PKNOX1 ZNF140 BMI1 EBF1 RELA YY1 ZNF316 GATA2 SCRT2 CEP57 FAM76B JRKL LOC101929295 SESN3 ENSG00000255605 GC11M095720
GH11F096061 1 Ensembl ENCODE 10.7 -327.2 -327233 2.1 ELF3 TFAP4 PKNOX1 SIN3A ZNF384 RAD21 RARA YY1 HNF4G MIXL1 CCDC82 JRKL GC11M095989 GC11P096202
GH11F096037 0.9 Ensembl ENCODE 11.1 -352.3 -352268 1.4 CTCF PKNOX1 RFX1 TAF1 CEBPB SMC3 PRDM10 RAD21 TRIM28 CCDC82 JRKL GC11M095989 GC11P096202
GH11F095484 0.6 ENCODE 12.5 -904.3 -904314 1.4 ZNF202 MAFG ZNF316 ZNF512 SCRT2 NFE2 ZBTB33 EMSY MGA CEP57 FAM76B ANKRD49 MRE11 JRKL SESN3 ENSG00000250390 GC11P095515
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JRKL on UCSC Golden Path with GeneCards custom track

Promoters for JRKL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000321172 -189 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for JRKL Gene

96,389,989 bp from pter
96,507,574 bp from pter
117,586 bases
Plus strand

Genomic View for JRKL Gene

Genes around JRKL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JRKL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JRKL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JRKL Gene

Proteins for JRKL Gene

  • Protein details for JRKL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Jerky protein homolog-like
    Protein Accession:
    Secondary Accessions:
    • A8K3G4
    • B2RAJ3
    • Q32MC2

    Protein attributes for JRKL Gene

    524 amino acids
    Molecular mass:
    59912 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB65833.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for JRKL Gene

Post-translational modifications for JRKL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JRKL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JRKL Gene

Domains & Families for JRKL Gene

Gene Families for JRKL Gene

Protein Domains for JRKL Gene

Suggested Antigen Peptide Sequences for JRKL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DDE-1 domain.
  • Belongs to the tigger transposable element derived protein family.
  • Contains 1 DDE-1 domain.
  • Contains 1 HTH CENPB-type DNA-binding domain.
  • Contains 1 HTH psq-type DNA-binding domain.
  • Belongs to the tigger transposable element derived protein family.
genes like me logo Genes that share domains with JRKL: view

Function for JRKL Gene

Molecular function for JRKL Gene

GENATLAS Biochemistry:
murine jerky homolog-like,involved in epileptic syndromes in mice,expressed in many tissues,with two alternatively forms in testis

Gene Ontology (GO) - Molecular Function for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with JRKL: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JRKL Gene

Localization for JRKL Gene

Subcellular locations from UniProtKB/Swiss-Prot for JRKL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JRKL gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with JRKL: view

Pathways & Interactions for JRKL Gene

No Data Available

Interacting Proteins for JRKL Gene

Gene Ontology (GO) - Biological Process for JRKL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 9240447
genes like me logo Genes that share ontologies with JRKL: view

No data available for Pathways by source and SIGNOR curated interactions for JRKL Gene

Transcripts for JRKL Gene

mRNA/cDNA for JRKL Gene

Unigene Clusters for JRKL Gene

Jerky homolog-like (mouse):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JRKL Gene

No ASD Table

Relevant External Links for JRKL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JRKL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JRKL Gene

Protein differential expression in normal tissues from HIPED for JRKL Gene

This gene is overexpressed in Heart (58.1) and Retina (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for JRKL Gene

Protein tissue co-expression partners for JRKL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JRKL Gene:


SOURCE GeneReport for Unigene cluster for JRKL Gene:


mRNA Expression by UniProt/SwissProt for JRKL Gene:

Tissue specificity: Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle.
genes like me logo Genes that share expression patterns with JRKL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for JRKL Gene

Orthologs for JRKL Gene

This gene was present in the common ancestor of chordates.

Orthologs for JRKL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia JRKL 34
  • 99.87 (n)
(Bos Taurus)
Mammalia JRKL 34 35
  • 92.37 (n)
(Canis familiaris)
Mammalia JRKL 34 35
  • 91.03 (n)
(Mus musculus)
Mammalia Jrkl 34 16 35
  • 89.8 (n)
(Rattus norvegicus)
Mammalia Jrkl 34
  • 88.93 (n)
(Monodelphis domestica)
Mammalia JRKL 35
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
Species where no ortholog for JRKL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JRKL Gene

Gene Tree for JRKL (if available)
Gene Tree for JRKL (if available)

Paralogs for JRKL Gene

Paralogs for JRKL Gene

(4) SIMAP similar genes for JRKL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JRKL: view

Variants for JRKL Gene

Sequence variations from dbSNP and Humsavar for JRKL Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1053028 -- 96,392,989(+) TTTTT(A/C/T)TTATG utr-variant-3-prime
rs10545425 -- 96,392,272(+) AACTC(-/TT)TGCAA utr-variant-3-prime
rs11021568 -- 96,388,691(+) ATCAC(C/T)TACTT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11021571 -- 96,393,146(+) tttaG(G/T)GTTTT utr-variant-3-prime
rs11021572 -- 96,393,148(+) taGTG(G/T)TTTTA utr-variant-3-prime

Variation tolerance for JRKL Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JRKL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JRKL Gene

Disorders for JRKL Gene

Relevant External Links for JRKL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JRKL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JRKL Gene

Publications for JRKL Gene

  1. Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product. (PMID: 9240447) Zeng Z. … Li Y. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies. (PMID: 22648509) Wang K.S. … Zeng M. (J. Mol. Neurosci. 2012) 3 64
  4. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PMID: 23128233) Jostins L. … Cho J.H. (Nature 2012) 3 64
  5. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 46 64

Products for JRKL Gene

Sources for JRKL Gene

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