JRKL Gene
protein-coding GIFtS: 43
GCID: GC11P096123
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jerky homolog-like (mouse)(Previous name: erky (mouse) homolog-like )
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Aliases
for JRKL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jerky Homolog-Like (Mouse)1 2 | | HHMJG1 2 3 5 | | Human Homolog Of Mouse Jerky Gene Protein2 3 | | Erky (Mouse) Homolog-Like1 | | Jerky Protein Homolog-Like2 |
Export aliases for JRKL gene to outside databasesPrevious GC identifers: GC11P098454 GC11P097631 GC11P096308 GC11P095811 GC11P095763 GC11P092189 |
Summaries
for JRKL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JRKL:
The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41%identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein.Alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, May 2012)
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Genomic Views
for JRKL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JRKL gene promoter:
POU2F2 (Oct-2.1) oct-B2 oct-B3 AML1a POU2F2 RORalpha1 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for JRKL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JRKL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21JRKL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P096123: view genomic region
(about GC identifiers)
Start:
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96,123,153 bp from pter |
End:
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96,240,738 bp from pter |
Size:
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117,586 bases |
Orientation:
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plus strand |
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Proteins
for JRKL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0 (See
protein sequence)Recommended Name: Jerky protein homolog-like Size: 524 amino acids; 59912 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAB65833.1; Type=Erroneous initiation;
Secondary accessions: A8K3G4 B2RAJ3 Q32MC2Explore the universe of human proteins at neXtProt for JRKL: NX_Q9Y4A0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4A0
JRKL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001248762.1 NP_003763.2
ENSEMBL proteins: ENSP00000333350 ENSP00000389989
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
JRKL for ontologies About GeneDecksing
JRKL Antibody Products:
Assay Products for JRKL: |
Protein
Domains /
Families
for JRKL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JRKL for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4A0ProtoNet protein and cluster: Q9Y4A0 1 Blocks protein family: IPB004875 CENP-B protein
UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0Similarity: Belongs to the tigger transposable element derived protein familySimilarity: Contains 1 DDE domainSimilarity: Contains 1 HTH CENPB-type DNA-binding domainSimilarity: Contains 1 HTH psq-type DNA-binding domain |
Function
for JRKL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for JRKL:murine jerky homolog-like,involved in epileptic syndromes in mice,expressed in many tissues,with two alternativelyforms in testis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRKL |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
JRKL for ontologies About GeneDecksing
|
Pathways & Interactions
for JRKL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JRKL
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007417 | central nervous system development |
TAS | 9240447 |
JRKL for ontologies About GeneDecksing
|
Drugs & Compounds
for JRKL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JRKL
Search CenterWatch for drugs/clinical trials and news about JRKL / JERKL
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Transcripts
for JRKL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JRKL gene (2 alternative transcripts): NM_001261833.1 NM_003772.3 Unigene Clusters for JRKL: Jerky homolog-like (mouse) Hs.105940 [show with all ESTs], Hs.722414 [show with all ESTs]Unigene Representative Sequences: NM_003772, NM_0012618333 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000546177(uc021qpa.1) ENST00000332349(uc009ywu.3) ENST00000458427(uc001pfy.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JRKL (NM_003772) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JRKL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JRKL |
Additional cDNA sequence: AK290579.1 BC031306.1 2 DOTS entries: DT.404002 DT.99932675 21 AceView cDNA sequences: AI985103 BU633595 NM_003772 CA503357 BM468034 AW662715 BQ719793 BG926401 AF004715 CA448235 BG403784 BX089945 BX472885 AI733607 AA991350 AI792197 BP334207 BG926222 BF242601 AW151655 BU588099
GeneLoc Exon Structure
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Expression
for JRKL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JRKL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAAAATG
About this image
See JRKL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JRKL
SOURCE GeneReport for Unigene clusters: Hs.105940 Hs.722414
UniProtKB/Swiss-Prot: JERKL_HUMAN, Q9Y4A0Tissue specificity: Abundantly expressed in the majority of tissues examined, including brain and skeletal muscle
SABiosciences Custom PCR Arrays for JRKL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JRKL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JRKL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JRKL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JRKL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRKL |
Orthologs
for JRKL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for JRKL gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for JRKL (if available)
TreeFam Gene Tree for JRKL (if available) |
Paralogs
for JRKL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JRKL gene
- TIGD22 TIGD12 CENPB2 TIGD62 TIGD42 TIGD72 TIGD52 TIGD32
4 SIMAP similar genes for JRKL using alignment to 1 protein entry: JERKL_HUMAN:TIGD2 JRK DKFZp686C24207 TIGD7
JRKL for paralogs About GeneDecksing
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Genomic Variants
for JRKL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JRKL (96123153 - 96240738 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for JRKL: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for JRKL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 JRKL for disorders About MalaCards
JRKL for disorders About GeneDecksing
OMIM gene information: 603211
OMIM disorders: --
Export disorders for JRKL gene to outside databases
|
Publications
for JRKL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JRKL gene integrated from 9 sources:
(articles sorted by number of sources associating them with JRKL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, mapping, and tissue distribution of a human homologue of the mouse jerky gene product. (PubMed id 9240447)1, 2, 3 Zeng Z.... Li Y. (1997)
- PKNOX2 is associated with formal thought disorder in s chizophrenia: a meta-analysis of two genome-wide association studies. (PubMed id 22648509)1 Wang K.S....Zeng M. (2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for JRKL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing JRKL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JRKL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JRKL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JRKL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for JRKL gene:
Search GeneIP for patents involving JRKL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JRKL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for JRKL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JRKL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JRKL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for JRKL | | OriGene 3'-UTR Clone for JRKL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JRKL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JRKL | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JRKL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JRKL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JRKL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JRKL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JRKL |
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 | | | JRKL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRKL |
|  |  |  | | | | Search ThermoFisher Antibodies for JRKL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JRKL |
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