JRK Gene
protein-coding GIFtS: 49
GCID: GC08M143735
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jerky homolog (mouse)(Previous name: jerky (mouse) homolog )
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Aliases
for JRK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jerky Homolog (Mouse)1 2 | | JH81 2 3 5 | | Jerky (Mouse) Homolog1 | | Jerky Protein Homolog2 |
Export aliases for JRK gene to outside databasesPrevious GC identifers: GC08M142043 GC08M143974 GC08M143548 GC08M143807 GC08M143808 GC08M138992 |
Summaries
for JRK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JRK:
This gene is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclearregulatory proteins, including centromere protein B, suggesting that it might function as a DNA-binding protein.Insertional inactivation of this gene in transgenic mice resulted in epileptic seizures. Childhood Absence Epilepsy(CAE) has been mapped to the same chromosomal location (8q24.3) as this gene, making this gene a strong candidate forCAE. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: JERKY_HUMAN, O75564Function: May bind DNA (By similarity)
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Genomic Views
for JRK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JRK gene promoter:
GATA-3 AML1a RREB-1 c-Ets-1 GATA-1 GATA-2 AREB6 FOXJ2 (long isoform) ZID FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for JRK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JRK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3JRK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M143735: view genomic region
(about GC identifiers)
Start:
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143,738,874 bp from pter |
End:
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143,763,386 bp from pter |
Size:
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24,513 bases |
Orientation:
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minus strand |
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Proteins
for JRK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JERKY_HUMAN, O75564 (See
protein sequence)Recommended Name: Jerky protein homolog Size: 520 amino acids; 57402 Da
Subcellular location: Nucleus (Potential)
Secondary accessions: O75565Explore the universe of human proteins at neXtProt for JRK: NX_O75564
JRK Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001070995.1 NP_003715.2
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
JRK for ontologies About GeneDecksing
JRK Antibody Products:
Assay Products for JRK: |
Protein
Domains /
Families
for JRK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JRK for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75564ProtoNet protein and cluster: O75564 1 Blocks protein family: IPB004875 CENP-B protein
UniProtKB/Swiss-Prot: JERKY_HUMAN, O75564Similarity: Belongs to the tigger transposable element derived protein familySimilarity: Contains 1 DDE domainSimilarity: Contains 1 HTH CENPB-type DNA-binding domain |
Function
for JRK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JERKY_HUMAN, O75564Function: May bind DNA (By similarity) Genatlas biochemistry entry for JRK:murine epilepsy jerky homolog on chromosome 8,widely expressed with a major large transcript and two smaller minortranscripts,not implicated in childhood absence epilepsy
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRK |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003677 | DNA binding |
IEA | -- |
JRK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for JRK:
Animal Models:
1 MGI phenotypic allele  for Jrk (no phenotypes)
JRK for phenotypes About GeneDecksing
|
Pathways & Interactions
for JRK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JRK
4 Interacting proteins for JRK (O755642) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
JRK for ontologies About GeneDecksing
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Drugs & Compounds
for JRK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JRK
Search CenterWatch for drugs/clinical trials and news about JRK / JERKY
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Transcripts
for JRK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JRK gene (2 alternative transcripts): NM_001077527.1 NM_003724.2 Unigene Clusters for JRK: Jerky homolog (mouse) Hs.535903 [show with all ESTs], Hs.683465 Unigene Representative Sequences: NM_003724, BC04335110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507178(uc003ywo.3 uc003ywp.3) ENST00000422119(uc022bcb.1)
ENST00000512113 ENST00000506774 ENST00000503272 ENST00000591357 ENST00000591180
ENST00000587883 ENST00000585503 ENST00000587499
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JRK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): JRK (NM_001077527) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JRK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JRK |
Additional cDNA sequence: BC043351.1 13 DOTS entries: DT.120639785 DT.431224 DT.75102893 DT.102826414 DT.436244 DT.101978738 DT.100023994 DT.86850649 DT.120639806 DT.40196070 DT.40247181 DT.95251395 DT.97818526 24/123 AceView cDNA sequences (see all 123): BP376551 BC036794 AF072468 BM713746 AK024975 Z45157 BM784502 AW513355 BC071862 BU738814 BM469061 BC030566 AI696719 AI193642 BQ070109 AK025687 BU159904 R54136 AA263118 BG481777 AI761905 BU677639 BM718840 BX640755
GeneLoc Exon Structure
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Expression
for JRK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JRK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCTTGTAC
About this image
Genevestigator expression for JRK
SOURCE GeneReport for Unigene clusters: Hs.535903 Hs.683465
UniProtKB/Swiss-Prot: JERKY_HUMAN, O75564Tissue specificity: Expressed ubiquitously
SABiosciences Custom PCR Arrays for JRK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JRK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JRK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JRK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JRK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRK |
Orthologs
for JRK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for JRK gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for JRK (if available)
TreeFam Gene Tree for JRK (if available) |
Paralogs
for JRK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for JRK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JRK (143738874 - 143763386 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JRK
1 CNV: 4791
Human Gene Mutation Database (HGMD): JRK
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for JRK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JRK for disorders About GeneDecksing
OMIM gene information: 603210
OMIM disorders: --
4  diseases for JRK: About MalaCardschildhood absence epilepsy absence epilepsy generalized epilepsy seizures
1 disease from the University of Copenhagen DISEASES database for JRK:Idiopathic generalized epilepsy Human Genome Epidemiology (HuGE) Navigator: JRK (1 document)
Export disorders for JRK gene to outside databases
|
Publications
for JRK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JRK gene integrated from 9 sources:
(articles sorted by number of sources associating them with JRK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24. (PubMed id 9675132)1, 2, 3, 9 Morita R.... Yamakawa K. (1998)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME. (PubMed id 11463517)1 Moore T....Bailleul B. (2001)
- Complex regulation and nuclear localization of JRK protein. (PubMed id 15506925)9 Waldron R. and Moore T. (2004)
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External Searches for JRK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing JRK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JRK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JRK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JRK | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for JRK gene:
Search GeneIP for patents involving JRK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JRK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JRK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JRK | | | OriGene Protein Over-expression Lysate for JRK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for JRK | | OriGene 3'-UTR Clone for JRK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JRK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JRK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for JRK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JRK | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JRK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JRK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JRK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JRK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JRK |
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 | | | JRK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JRK |
|  |  |  | | | | ThermoFisher Antibody for JRK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JRK |
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