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Aliases for JRK Gene

Aliases for JRK Gene

  • Jrk Homolog (Mouse) 2 3
  • JH8 3 4 6
  • Jerky (Mouse) Homolog 2
  • Jerky Homolog (Mouse) 2
  • Jerky Protein Homolog 3
  • Jerky Homolog 3
  • Jerky 3

External Ids for JRK Gene

Summaries for JRK Gene

Entrez Gene Summary for JRK Gene

  • This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for JRK Gene

JRK (Jrk Homolog (Mouse)) is a Protein Coding gene. Diseases associated with JRK include childhood absence epilepsy and epilepsy, generalized, with febrile seizures plus, type 5.

UniProtKB/Swiss-Prot for JRK Gene

  • May bind DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JRK Gene

Genomics for JRK Gene

Genomic Location for JRK Gene

Start:
142,657,460 bp from pter
End:
142,681,968 bp from pter
Size:
24,509 bases
Orientation:
Minus strand

Genomic View for JRK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JRK Gene

Regulatory Elements for JRK Gene

Proteins for JRK Gene

  • Protein details for JRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75564-JERKY_HUMAN
    Recommended name:
    Jerky protein homolog
    Protein Accession:
    O75564
    Secondary Accessions:
    • O75565

    Protein attributes for JRK Gene

    Size:
    520 amino acids
    Molecular mass:
    57402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JRK Gene

Proteomics data for JRK Gene at MOPED

Post-translational modifications for JRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JRK Gene

No data available for DME Specific Peptides for JRK Gene

Domains for JRK Gene

Protein Domains for JRK Gene

UniProtKB/Swiss-Prot:

JERKY_HUMAN
Domain:
  • Contains 1 DDE domain.:
    • O75564
  • Contains 1 HTH CENPB-type DNA-binding domain.:
    • O75564
Family:
  • Belongs to the tigger transposable element derived protein family.:
    • O75564
genes like me logo Genes that share domains with JRK: view

No data available for Gene Families for JRK Gene

Function for JRK Gene

Molecular function for JRK Gene

GENATLAS Biochemistry: murine epilepsy jerky homolog on chromosome 8,widely expressed with a major large transcript and two smaller minor transcripts,not implicated in childhood absence epilepsy
UniProtKB/Swiss-Prot Function: May bind DNA.

Gene Ontology (GO) - Molecular Function for JRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003729 mRNA binding --
GO:0005515 protein binding IPI 21399610
genes like me logo Genes that share ontologies with JRK: view

Phenotypes for JRK Gene

GenomeRNAi human phenotypes for JRK:
genes like me logo Genes that share phenotypes with JRK: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for JRK Gene

Localization for JRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for JRK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JRK Gene COMPARTMENTS Subcellular localization image for JRK gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for JRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0030529 ribonucleoprotein complex --
genes like me logo Genes that share ontologies with JRK: view

Pathways for JRK Gene

SuperPathways for JRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for JRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with JRK: view

No data available for Pathways by source for JRK Gene

Transcripts for JRK Gene

Unigene Clusters for JRK Gene

Jerky homolog (mouse):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JRK Gene

No ASD Table

Relevant External Links for JRK Gene

GeneLoc Exon Structure for
JRK
ECgene alternative splicing isoforms for
JRK

Expression for JRK Gene

mRNA expression in normal human tissues for JRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JRK Gene

This gene is overexpressed in Stomach (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for JRK Gene

SOURCE GeneReport for Unigene cluster for JRK Gene Hs.535903

mRNA Expression by UniProt/SwissProt for JRK Gene

O75564-JERKY_HUMAN
Tissue specificity: Expressed ubiquitously.
genes like me logo Genes that share expressions with JRK: view

Orthologs for JRK Gene

This gene was present in the common ancestor of mammals.

Orthologs for JRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JRK 36
  • 98.73 (n)
  • 98.29 (a)
cow
(Bos Taurus)
Mammalia JRK 36
  • 77.86 (n)
  • 74.95 (a)
dog
(Canis familiaris)
Mammalia JRK 36
  • 79.67 (n)
  • 78.19 (a)
mouse
(Mus musculus)
Mammalia Jrk 36
  • 78.72 (n)
  • 77.52 (a)
Jrk 16
rat
(Rattus norvegicus)
Mammalia Jrk 36
  • 79.14 (n)
  • 78.42 (a)
Species with no ortholog for JRK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JRK Gene

ENSEMBL:
Gene Tree for JRK (if available)
TreeFam:
Gene Tree for JRK (if available)

Paralogs for JRK Gene

Selected SIMAP similar genes for JRK Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with JRK: view

No data available for Paralogs for JRK Gene

Variants for JRK Gene

Sequence variations from dbSNP and Humsavar for JRK Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs750529 -- 142,663,460(+) ACGTG(C/G)AAACC intron-variant, utr-variant-3-prime
rs750530 -- 142,663,514(+) AGGCC(A/G)TAAGT intron-variant, utr-variant-3-prime
rs754957 -- 142,664,997(+) CGGGC(A/G)TGGGG reference, synonymous-codon
rs1056012 -- 142,658,755(-) TCCAT(C/G/T)TCCAT utr-variant-3-prime, intron-variant
rs1137521 -- 142,657,748(-) TGGGA(A/G)ATGTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JRK Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV Deletion 23128226
dgv7910n71 CNV Loss 21882294
dgv7914n71 CNV Loss 21882294
dgv7915n71 CNV Loss 21882294
dgv7916n71 CNV Loss 21882294
nsv428207 CNV Gain+Loss 18775914
nsv891637 CNV Loss 21882294
nsv831485 CNV Loss 17160897

Relevant External Links for JRK Gene

HapMap Linkage Disequilibrium report
JRK
Human Gene Mutation Database (HGMD)
JRK

Disorders for JRK Gene

(1) University of Copenhagen DISEASES for JRK Gene

Relevant External Links for JRK

Genetic Association Database (GAD)
JRK
Human Genome Epidemiology (HuGE) Navigator
JRK
genes like me logo Genes that share disorders with JRK: view

No data available for UniProtKB/Swiss-Prot for JRK Gene

Publications for JRK Gene

  1. JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24. (PMID: 9675132) Morita R. … Yamakawa K. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating I^-catenin-TCF activity. (PMID: 21399610) Benchabane H. … Ahmed Y. (EMBO J. 2011) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for JRK Gene

Sources for JRK Gene

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