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Aliases for JPT1 Gene

Aliases for JPT1 Gene

  • Jupiter Microtubule Associated Homolog 1 2 3
  • Androgen-Regulated Protein 2 2 3 4
  • HN1 3 4 5
  • Hematological And Neurological Expressed 1 2 5
  • ARM2 3 4
  • Hematological And Neurological Expressed 1 Protein 3
  • HN1A 3

External Ids for JPT1 Gene

Previous HGNC Symbols for JPT1 Gene

  • HN1

Summaries for JPT1 Gene

GeneCards Summary for JPT1 Gene

JPT1 (Jupiter Microtubule Associated Homolog 1) is a Protein Coding gene. Diseases associated with JPT1 include Testicular Leukemia. Among its related pathways are Apoptosis Modulation and Signaling.

Gene Wiki entry for JPT1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JPT1 Gene

Genomics for JPT1 Gene

Regulatory Elements for JPT1 Gene

Enhancers for JPT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G075123 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +43.3 43341 2.9 HDGF PKNOX1 ARNT SIN3A YY1 ZNF766 CBX5 FOS ZHX2 JUNB NUP85 JPT1 NT5C SUMO2 ATP5H KCTD2 MRPL58 MRPS7 TSEN54 SLC16A5
GH17G075109 1.3 ENCODE dbSUPER 12.4 +58.2 58230 2.0 PKNOX1 AGO1 WRNIP1 ARID4B SIN3A ZNF48 ETS1 GTF3C2 ELK1 ZNF207 NUP85 UNK NT5C ENSG00000266980 H3F3B JPT1 ATP5H KCTD2 TSEN54 ARMC7
GH17G075113 1.2 ENCODE dbSUPER 12.4 +53.8 53811 1.6 ATF1 ARID4B SIN3A ZNF48 ZNF766 GATA2 ZNF143 DEK MXD4 REST NUP85 JPT1 ATP5H KCTD2 SLC16A5 ARMC7 GC17P075119 PIR52086
GH17G075073 1.1 ENCODE dbSUPER 11.8 +94.1 94070 1.6 HDAC1 PKNOX1 ESRRA ZMYM3 UBTF CEBPG ZNF48 TCF12 GATA2 NCOR1 KCTD2 ATP5H JPT1 TMEM94 TRIM80P CDR2L MRPS7 PIR52580
GH17G075072 1 ENCODE 11.8 +96.1 96081 0.2 HDGF PKNOX1 FOXA2 ATF1 ARNT ARID4B TCF12 FOS MXD4 ZHX2 ATP5H KCTD2 JPT1 TMEM94 PIR52580 TRIM80P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JPT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for JPT1 Gene

Chromosome:
17
Start:
75,135,243 bp from pter
End:
75,168,281 bp from pter
Size:
33,039 bases
Orientation:
Minus strand

Genomic View for JPT1 Gene

Genes around JPT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JPT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JPT1 Gene

Proteins for JPT1 Gene

  • Protein details for JPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK76-HN1_HUMAN
    Recommended name:
    Hematological and neurological expressed 1 protein
    Protein Accession:
    Q9UK76
    Secondary Accessions:
    • B2R6K3
    • Q53FG7
    • Q7Z2D2
    • Q7Z2F0

    Protein attributes for JPT1 Gene

    Size:
    154 amino acids
    Molecular mass:
    16015 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JPT1 Gene

Post-translational modifications for JPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JPT1 Gene

Domains & Families for JPT1 Gene

Protein Domains for JPT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK76

UniProtKB/Swiss-Prot:

HN1_HUMAN :
  • Belongs to the HN1 family.
Family:
  • Belongs to the HN1 family.
genes like me logo Genes that share domains with JPT1: view

No data available for Gene Families for JPT1 Gene

Function for JPT1 Gene

Phenotypes for JPT1 Gene

genes like me logo Genes that share phenotypes with JPT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JPT1 Gene

Localization for JPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JPT1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JPT1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for JPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with JPT1: view

Pathways & Interactions for JPT1 Gene

genes like me logo Genes that share pathways with JPT1: view

Pathways by source for JPT1 Gene

1 BioSystems pathway for JPT1 Gene

Gene Ontology (GO) - Biological Process for JPT1 Gene

None

No data available for SIGNOR curated interactions for JPT1 Gene

Drugs & Compounds for JPT1 Gene

No Compound Related Data Available

Transcripts for JPT1 Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for JPT1 Gene

No ASD Table

Relevant External Links for JPT1 Gene

GeneLoc Exon Structure for
JPT1
ECgene alternative splicing isoforms for
JPT1

Expression for JPT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of JPT1 Gene:

JPT1

mRNA Expression by UniProt/SwissProt for JPT1 Gene:

Q9UK76-HN1_HUMAN
Tissue specificity: Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.

Evidence on tissue expression from TISSUES for JPT1 Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Liver(4.3)
  • Lung(3.5)
  • Intestine(2.5)
  • Lymph node(2.3)
  • Skin(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JPT1 Gene

Orthologs for JPT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HN1 35 34
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia HN1 34 35
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia HN1 34 35
  • 89.39 (n)
rat
(Rattus norvegicus)
Mammalia Hn1 34
  • 88.37 (n)
mouse
(Mus musculus)
Mammalia Hn1 34 35
  • 88.1 (n)
Jpt1 16
oppossum
(Monodelphis domestica)
Mammalia HN1 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves HN1 34 35
  • 73.42 (n)
lizard
(Anolis carolinensis)
Reptilia HN1 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hn1 34
  • 53.43 (n)
zebrafish
(Danio rerio)
Actinopterygii hn1a 34 35
  • 51.54 (n)
hn1b 35
  • 31 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7331 34
Species where no ortholog for JPT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JPT1 Gene

ENSEMBL:
Gene Tree for JPT1 (if available)
TreeFam:
Gene Tree for JPT1 (if available)

Paralogs for JPT1 Gene

Pseudogenes.org Pseudogenes for JPT1 Gene

genes like me logo Genes that share paralogs with JPT1: view

No data available for Paralogs for JPT1 Gene

Variants for JPT1 Gene

Sequence variations from dbSNP and Humsavar for JPT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000108112 -- 75,144,526(+) AAAAA(A/T)AAATG intron-variant
rs1000299 -- 75,152,458(+) AAAAA(A/G)GGAAG intron-variant
rs1000449394 -- 75,155,847(+) TTTTT(G/T)TATTT upstream-variant-2KB
rs1000872486 -- 75,151,707(+) GCTCA(C/T)GCCTG intron-variant
rs1000944120 -- 75,151,416(+) ACTTT(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JPT1 Gene

Variant ID Type Subtype PubMed ID
nsv470602 CNV loss 18288195

Variation tolerance for JPT1 Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JPT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JPT1 Gene

Disorders for JPT1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for JPT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards
Search JPT1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for JPT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JPT1
genes like me logo Genes that share disorders with JPT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JPT1 Gene

Publications for JPT1 Gene

  1. Cloning, expression and subcellular localization of HN1 and HN1L genes, as well as characterization of their orthologs, defining an evolutionarily conserved gene family. (PMID: 15094197) Zhou G. … Zhao S. (Gene 2004) 2 3 4 64
  2. Jupiter, a new Drosophila protein associated with microtubules. (PMID: 16518797) Karpova N. … Debec A. (Cell Motil. Cytoskeleton 2006) 2 3 64
  3. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PMID: 16602700) Zougman A. … Wisniewski J.R. (J. Proteome Res. 2006) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for JPT1 Gene

Sources for JPT1 Gene

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