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JPH4 Gene

protein-coding   GIFtS: 44
GCID: GC14M024037

Junctophilin 4

(Previous name: junctophilin like 1)
(Previous symbol: JPHL1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Junctophilin 41 2     JP-42 3
JPHL11 2 3     JP42
Junctophilin Like 11 2     junctophilin-42
Junctophilin-Like 1 Protein2 3     KIAA18313

External Ids:    HGNC: 201561   Entrez Gene: 845022   Ensembl: ENSG000000920517   UniProtKB: Q96JJ63   

Export aliases for JPH4 gene to outside databases

Previous GC identifers: GC14M022027 GC14M023099 GC14M023109 GC14M004153


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JPH4 Gene:
This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation
of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in
excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation
and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Mar 2009)

GeneCards Summary for JPH4 Gene:
JPH4 (junctophilin 4) is a protein-coding gene. An important paralog of this gene is JPH2.

UniProtKB/Swiss-Prot: JPH4_HUMAN, Q96JJ6
Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma
membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for
functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific
and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the JPH4 gene promoter:
         Max1   Elk-1   Pax-5   AP-2beta   AP-2alpha   AP-2gamma   Pax-4a   c-Myc   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJPH4 promoter sequence
   Search Chromatin IP Primers for JPH4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JPH4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

JPH4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JPH4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024037:  view genomic region     (about GC identifiers)

Start:
24,037,244 bp from pter      End:
24,048,009 bp from pter
Size:
10,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: JPH4_HUMAN, Q96JJ6 (See protein sequence)
Recommended Name: Junctophilin-4  
Size: 628 amino acids; 65861 Da
Sequence caution: Sequence=BAB47460.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB70905.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: D3DS53 Q8ND44 Q96DQ0

Explore the universe of human proteins at neXtProt for JPH4: NX_Q96JJ6

Explore proteomics data for JPH4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JPH4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139500.1  NP_115828.2  

    ENSEMBL proteins: 
     ENSP00000348648   ENSP00000380307   ENSP00000439562  

    JPH4 Human Recombinant Protein Products:

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    antibodies-online proteins for JPH4 (2 products) 

     
    antibodies-online peptides for JPH4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017191 Junctophilin
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q96JJ6

    ProtoNet protein and cluster: Q96JJ6

    UniProtKB/Swiss-Prot: JPH4_HUMAN, Q96JJ6
    Domain: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding,
    possibly by interacting with phospholipids (By similarity)
    Similarity: Belongs to the junctophilin family
    Similarity: Contains 8 MORN repeats


    Find genes that share domains with JPH4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JPH4_HUMAN, Q96JJ6
    Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma
    membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for
    functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific
    and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity)

    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jph4):

     behavior/neurological  growth/size/body  mortality/aging  nervous system  reproductive system 

    Find genes that share phenotypes with JPH4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Jph4tm1Hta for JPH4

       genOway: Develop your customized and physiologically relevant rodent model for JPH4

    miRNA
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    hsa-let-7a-5p (MIRT052517)

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    hsa-miR-411* hsa-miR-345 hsa-miR-1321 hsa-miR-379* hsa-miR-1224-3p hsa-miR-30d hsa-miR-650 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidJPH4 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JPH4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JPH4_HUMAN, Q96JJ6: Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane;
    Single-pass type IV membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The
    transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the
    plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005790smooth endoplasmic reticulum IEA--
    GO:0005886plasma membrane IEA--
    GO:0014701junctional sarcoplasmic reticulum membrane TAS19095005
    GO:0016021integral component of membrane IEA--
    GO:0043198dendritic shaft IEA--

    Find genes that share ontologies with JPH4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JPH4
    Interactions:

        GeneGlobe Interaction Network for JPH4

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007612learning IEA--
    GO:0048167regulation of synaptic plasticity IEA--
    GO:0050885neuromuscular process controlling balance IEA--
    GO:0060314regulation of ryanodine-sensitive calcium-release channel activity TAS19095005
    GO:0060402calcium ion transport into cytosol TAS19095005

    Find genes that share ontologies with JPH4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JPH4

    4 Novoseek inferred chemical compound relationships for JPH4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannose 24.9 1 16864654 (1)
    lysine 16.6 2 17483134 (1), 8468349 (1)
    alanine 5.11 1 11247301 (1)
    tyrosine 0 2 11247301 (1), 19489740 (1)



    Find genes that share compounds with JPH4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JPH4 gene (2 alternative transcripts): 
    NM_001146028.1  NM_032452.2  

    Unigene Cluster for JPH4:

    Junctophilin 4
    Hs.597841  [show with all ESTs]
    Unigene Representative Sequence: NM_032452
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356300(uc010tnr.1 uc001wkr.2) ENST00000397118(uc001wkq.2)
    ENST00000544177 ENST00000553505(uc001wks.2)
    miRNA
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    hsa-miR-411* hsa-miR-345 hsa-miR-1321 hsa-miR-379* hsa-miR-1224-3p hsa-miR-30d hsa-miR-650 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidJPH4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): JPH4 (NM_032452)
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      QuantiTect SYBR Green Assays in human, mouse, rat JPH4
      QuantiFast Probe-based Assays in human, mouse, rat JPH4

    Additional mRNA sequence: 

    AB058734.1 AK055345.1 AK091572.1 AK290511.1 AK304514.1 AL834411.1 AY344068.1 BC055429.1 
    BC109228.2 

    5 DOTS entries:

    DT.456303  DT.97839045  DT.95120470  DT.411162  DT.120750750 

    Selected AceView cDNA sequences (see all 328):

    BG911312 AI733643 AW131744 BM991918 AI159866 AI951789 BF195169 CD742635 
    BX453428 AI129936 BQ709146 AB058734 BM980959 AI288799 BQ054727 BM675924 
    AW961067 BX493457 CR611477 AI829725 BX400236 BI524171 BG993984 BG752700 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for JPH4 (see all 29)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a ·
    SP1:                                                                                                  -     -     -     -           -                           
    SP2:                                                                                                                                -     -                     
    SP3:                                                                                                  -     -     -     -           -     -                     
    SP4:                                                                                                                                -     -                     
    SP5:                                                                                                                                                            

    ExUns: 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20 ^ 21a · 21b · 21c · 21d · 21e ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^
    SP1:  -     -                                   -     -                             -                 -     -                       -                           
    SP2:  -     -     -     -     -                 -     -                                                                                                         
    SP3:  -     -                                                                                                                                                   
    SP4:  -     -                                   -     -                                                                                                         
    SP5:                                            -     -                                               -     -                                                   

    ExUns: 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b
    SP1:              -                           
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for JPH4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JPH4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATTTGGGA
    JPH4 Expression
    About this image


    JPH4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 24 entries
             Thalamus
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
             Floor plate-like cells
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    JPH4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JPH4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597841
        Custom PCR Arrays for JPH4
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JPH4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jph41 , 5 junctophilin 41, 5 89.76(n)1
    96.18(a)1
      14 (28.07 cM)5
    3199841  NM_177049.51  NP_796023.21 
     551068305 
    lizard
    (Anolis carolinensis)
    Reptilia JPH46
    junctophilin 4
    59(a)
    1 ↔ 1
    GL343877.1(85591-110111)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004900431 junctophilin-4-like 55.99(n)
    57.78(a)
      100490043  XM_002941519.2  XP_002941565.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta jp6
    junctophilin
    21(a)
    1 → many
    2L(9547720-9566750)
    worm
    (Caenorhabditis elegans)
    Secernentea jph-16
    Protein JPH-1 (jph-1) mRNA, complete cds
    30(a)
    1 → many
    I(7946222-7951593) WBGene00002179


    ENSEMBL Gene Tree for JPH4 (if available)
    TreeFam Gene Tree for JPH4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JPH4 gene
    JPH22  JPH12  JPH32  
    4 SIMAP similar genes for JPH4 using alignment to 2 protein entries:     JPH4_HUMAN (see all proteins):
    JPH3    DKFZp779I2251    JPH1    JPH2

    Find genes that share paralogs with JPH4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JPH4 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869437731,2
    --24039408(+) AGGGAA/GGGAAC 2 -- int10--------
    rs101495101,2
    C,F,A,H--24039559(+) GTTTAC/TAACCC 2 -- int120Minor allele frequency- T:0.36NS EA NA WA CSA 2339
    rs3743137631,2
    C--24039575(+) AAGTT-/ACTTTTT 2 -- int10--------
    rs1904474401,2
    --24039647(+) GCGATA/CTCAGC 2 -- int10--------
    rs286677521,2
    C--24039742(+) CGCCCA/GGCTAA 2 -- int10--------
    rs1179234291,2
    C,F--24039983(+) ACGCCC/TTCTAT 2 -- int11Minor allele frequency- T:0.02NA 120
    rs1487041391,2
    --24040014(+) TCCAAG/TACTGG 2 -- int10--------
    rs2006607801,2
    --24040051(+) AAAAG-/CCCCCC 2 -- int10--------
    rs778024641,2
    C--24040057(+) CCCCCC/G/TGGTGA 2 -- int10--------
    rs1901031,2
    C,H--24040143(+) GGCTGG/AGCAGG 4 /A syn17Minor allele frequency- A:0.00EA NA NS 472

    HapMap Linkage Disequilibrium report for JPH4 (24037244 - 24048009 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for JPH4: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing JPH4
    DNA2.0 Custom Variant and Variant Library Synthesis for JPH4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with JPH4           About GenesLikeMe

    8 Novoseek inferred disease relationships for JPH4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 49.5 7 7722498 (1), 17059559 (1), 16938437 (1), 16098915 (1) (see all 7)
    senile plaques 34.3 1 16938437 (1)
    adenocarcinoma 9.9 2 15987679 (1), 16707592 (1)
    necrosis 0 2 10672498 (1), 8702885 (1)
    inflammation 0 1 17275839 (1)
    colorectal cancer 0 1 18166351 (1)
    tumors 0 4 19601832 (1), 10672498 (1), 12379327 (1), 8702885 (1)
    cancer 0 1 12379327 (1)


    Export disorders for JPH4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JPH4 gene, integrated from 10 sources (see all 134):
    (articles sorted by number of sources associating them with JPH4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. (PubMed id 19095005)1 Yamazaki D....Takeshima H. (amp 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Coexpression of junctophilin type 3 and type 4 in brain. (PubMed id 14559359)1 Nishi M....Takeshima H. (Brain Res. Mol. Brain Res. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Accurate estimation of gene evolutionary rates using XRATE, with an application to transmembrane proteins. (PubMed id 19380462)9 Heger A....Holmes I. (Mol. Biol. Evol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84502 HGNC: 20156 AceView: AP1G2 Ensembl:ENSG00000092051 euGenes: HUgn84502
    ECgene: JPH4 H-InvDB: JPH4

    (According to HUGE)
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    HUGE: KIAA1831

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JPH4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JPH4 gene:
    Search GeneIP for patents involving JPH4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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