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JPH1 Gene

protein-coding   GIFtS: 54
GCID: GC08M075199

Junctophilin 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Junctophilin 11 2     Junctophilin Type12
JP12 3 5     junctophilin-12
Junctophilin Type 12 3     mitsugumin722
JP-12 3     

External Ids:    HGNC: 142011   Entrez Gene: 567042   Ensembl: ENSG000001043697   OMIM: 6052665   UniProtKB: Q9HDC53   

Export aliases for JPH1 gene to outside databases

Previous GC identifers: GC08M074201 GC08M075089 GC08M074870 GC08M075196 GC08M075309 GC08M070637


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JPH1 Gene:
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of
all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein
encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment
spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific
affinity for the plasma membrane. This gene is a member of the junctophilin gene family. (provided by RefSeq, Jul
2008)

GeneCards Summary for JPH1 Gene:
JPH1 (junctophilin 1) is a protein-coding gene. GO annotations related to this gene include structural constituent of muscle. An important paralog of this gene is JPH2.

UniProtKB/Swiss-Prot: JPH1_HUMAN, Q9HDC5
Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma
membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for
functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to
the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic
reticulum) membranes

Gene Wiki entry for JPH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JPH1 gene promoter:
         p53   AP-1   MIF-1   AP-4   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   E4BP4   POU3F2   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJPH1 promoter sequence
   Search Chromatin IP Primers for JPH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21

JPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JPH1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M075199:  view genomic region     (about GC identifiers)

Start:
75,146,935 bp from pter      End:
75,233,563 bp from pter
Size:
86,629 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JPH1_HUMAN, Q9HDC5 (See protein sequence)
Recommended Name: Junctophilin-1  
Size: 661 amino acids; 71686 Da
Secondary accessions: B2RTZ0

Explore the universe of human proteins at neXtProt for JPH1: NX_Q9HDC5

Explore proteomics data for JPH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JPH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065698.1  
    ENSEMBL proteins: 
     ENSP00000344488   ENSP00000429652  

    JPH1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR017191 Junctophilin
     IPR003409 MORN

    Graphical View of Domain Structure for InterPro Entry Q9HDC5

    ProtoNet protein and cluster: Q9HDC5

    1 Blocks protein domain: IPB003409 MORN motif

    UniProtKB/Swiss-Prot: JPH1_HUMAN, Q9HDC5
    Domain: The MORN (membrane occupation and recognition nexus) repeats contribute to the plasma membrane binding,
    possibly by interacting with phospholipids (By similarity)
    Similarity: Belongs to the junctophilin family
    Similarity: Contains 7 MORN repeats


    Find genes that share domains with JPH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JPH1_HUMAN, Q9HDC5
    Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma
    membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for
    functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to
    the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic
    reticulum) membranes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008307structural constituent of muscle IEA--
         
    Find genes that share ontologies with JPH1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for JPH1:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Jph1):
     behavior/neurological  mortality/aging  muscle 

    Find genes that share phenotypes with JPH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Jph1tm1Hta for JPH1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JPH1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JPH1

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    miRTarBase miRNAs that target JPH1:
    hsa-mir-99a-5p (MIRT048673), hsa-mir-100-5p (MIRT048572), hsa-mir-21-5p (MIRT030841), hsa-mir-7-5p (MIRT025712)

    Block miRNA regulation of human, mouse, rat JPH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JPH1 (see all 40):
    hsa-miR-579 hsa-miR-4291 hsa-miR-300 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-15a hsa-miR-424 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidJPH1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JPH1_HUMAN, Q9HDC5: Cell membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum membrane;
    Single-pass type IV membrane protein (By similarity). Sarcoplasmic reticulum membrane; Single-pass type IV
    membrane protein (By similarity). Note=Localized predominantly on the plasma membrane. The transmembrane domain
    is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma
    membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane ----
    GO:0005886plasma membrane IEA--
    GO:0014701junctional sarcoplasmic reticulum membrane TAS19095005
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with JPH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JPH1
    Interactions:

        Search GeneGlobe Interaction Network for JPH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for JPH1 (Q9HDC53 ENSP000003444884) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD3P840223, ENSP000003329734I2D: score=1 STRING: ENSP00000332973
    TP63Q9H3D43, ENSP000002647314I2D: score=1 STRING: ENSP00000264731
    TP73O153503, ENSP000003675454I2D: score=1 STRING: ENSP00000367545
    JPH2ENSP000003620714STRING: ENSP00000362071
    JPH3ENSP000002842624STRING: ENSP00000284262
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--
    GO:0060314regulation of ryanodine-sensitive calcium-release channel activity TAS19095005
    GO:0060402calcium ion transport into cytosol TAS19095005

    Find genes that share ontologies with JPH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JPH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JPH1 gene: 
    NM_020647.2  

    Unigene Cluster for JPH1:

    Junctophilin 1
    Hs.657367  [show with all ESTs]
    Unigene Representative Sequence: NM_020647
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342232(uc003yae.3 uc003yaf.3 uc003yag.1) ENST00000518195
    ENST00000519947
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate JPH1 (see all 40):
    hsa-miR-579 hsa-miR-4291 hsa-miR-300 hsa-miR-513a-5p hsa-miR-4272 hsa-miR-15a hsa-miR-424 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidJPH1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat JPH1
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      QuantiFast Probe-based Assays in human, mouse, rat JPH1

    Additional mRNA sequence: 

    BC017980.1 BC049372.1 BC098299.1 BC098314.1 BC099736.1 BC113856.1 BC114464.1 BC139832.1 
    BC140875.1 BC140876.1 BX537756.1 CR627477.1 

    3 DOTS entries:

    DT.309953  DT.91696464  DT.121478254 

    Selected AceView cDNA sequences (see all 35):

    BU687964 AW769210 AA456243 BC017980 AW170029 BM681376 CR627477 BI914643 
    BX537756 AI193262 Z25205 AI689205 AW674352 AW272576 BM728204 AI332493 
    AI741125 BX488426 BC049372 AW339949 AA134132 AA715374 NM_020647 AA639181 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for JPH1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                                                
    SP2:        -                                       


    ECgene alternative splicing isoforms for JPH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JPH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGTTTA
    JPH1 Expression
    About this image


    JPH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Brain (Nervous System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Skeletal Muscle (Muscoskeletal System)
    JPH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JPH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657367

    UniProtKB/Swiss-Prot: JPH1_HUMAN, Q9HDC5
    Tissue specificity: Abundantly expressed in skeletal muscle. Very low levels in heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JPH1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jph11 , 5 junctophilin 11, 5 90.02(n)1
    93.62(a)1
      1 (5.17 cM)5
    573391  NM_020604.21  NP_065629.11 
     169949385 
    chicken
    (Gallus gallus)
    Aves JPH11 junctophilin 1 76.55(n)
    80.43(a)
      420190  XM_418302.4  XP_418302.4 
    lizard
    (Anolis carolinensis)
    Reptilia JPH16
    junctophilin 1
    74(a)
    1 ↔ 1
    4(33893020-33957679)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ065316.12   -- 87.05(n)    BJ065316.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jph1b1 junctophilin 1b 69.12(n)
    72.04(a)
      556485  NM_001044348.1  NP_001037813.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta jp6
    junctophilin
    25(a)
    1 → many
    2L(9547720-9566750)
    worm
    (Caenorhabditis elegans)
    Secernentea jph-16
    Protein JPH-1 (jph-1) mRNA, complete cds
    33(a)
    1 → many
    I(7946222-7951593) WBGene00002179


    ENSEMBL Gene Tree for JPH1 (if available)
    TreeFam Gene Tree for JPH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JPH1 gene
    JPH22  JPH42  JPH32  
    8 SIMAP similar genes for JPH1 using alignment to 4 protein entries:     JPH1_HUMAN (see all proteins):
    DKFZp762L0313    DKFZp779I2251    JPH3    MORN2    JPH2    JPH4
    LOC118812    MORN4

    Find genes that share paralogs with JPH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JPH1 (see all 1897)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402935881,2
    --75146492(+) GGTGGC/TAGGTT 1 -- ds50010--------
    rs799102751,2
    C,F--75146616(+) AGTGCC/TCATGT 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1843279391,2
    --75146742(+) AAATTA/TTTTGA 1 -- ds50010--------
    rs1881129131,2
    --75146824(+) TTTTTC/TCCTTC 1 -- ds50010--------
    rs1809191221,2
    --75147112(+) TTCATA/GTGCTG 1 -- ut310--------
    rs1870574741,2
    --75147159(+) AAGAGC/GCTTCA 1 -- ut310--------
    rs37800111,2
    C,F,H--75147168(+) CATGTA/GAAATA 1 -- ut31 ese37Minor allele frequency- G:0.00NS EA NA 668
    rs37800121,2
    C,F,H--75147209(+) AATTTG/CAGCTT 1 -- ut314Minor allele frequency- C:0.00NS EA 414
    rs1822314501,2
    --75147286(+) CATATC/TCTCTC 1 -- ut310--------
    rs573751871,2
    C,F--75147324(+) CATTAC/TGCATT 1 -- ut311Minor allele frequency- T:0.23WA 118

    HapMap Linkage Disequilibrium report for JPH1 (75146935 - 75233563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for JPH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672906CNV Deletion23128226
    nsv515910CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JPH1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605266    OMIM disorders: --


    Find genes that share disorders with JPH1           About GenesLikeMe

    Genetic Association Database (GAD): JPH1
    Human Genome Epidemiology (HuGE) Navigator: JPH1 (3 documents)

    Export disorders for JPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JPH1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with JPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human junctophilin subtype genes. (PubMed id 10891348)1, 2, 3, 9 Nishi M.... Takeshima H. (Biochem. Biophys. Res. Commun. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
    5. Junctophilins: a novel family of junctional membrane complex proteins. (PubMed id 10949023)1, 3 Takeshima H....Kangawa K. (Mol. Cell 2000)
    6. Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle. (PubMed id 23148318)1 Murphy R.M....Lamb G.D. (J. Physiol. (Lond.) 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Junctophilin 1 and 2 proteins interact with the L-type Ca2+ channel dihydropyridine receptors (DHPRs) in skeletal muscle. (PubMed id 22020936)1 Golini L....Sorrentino V. (J. Biol. Chem. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56704 HGNC: 14201 AceView: JPH1 Ensembl:ENSG00000104369 euGenes: HUgn56704
    ECgene: JPH1 H-InvDB: JPH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JPH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JPH1 gene:
    Search GeneIP for patents involving JPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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