TAF1D Gene
protein-coding GIFtS: 41
GC11M093195
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TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa (Previous name: Josephin domain containing 3 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: JOSD3)
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Aliases & Descriptions for TAF1D
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| JOSD3 2, 3 | | MGC5306 1, 2 | | TAF(I)41 1, 2 | | TAFI41 3 |
| | | Descriptions |
|---|
| Josephin domain containing 3 1, 2 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 2 | TATA box binding protein-associated factor, RNA polymerase I, D, 41kDa 1 | | TATA box-binding protein-associated factor 1D 3 | | TBP-associated factor 1D 3 | | TBP-associated factor RNA polymerase I 41 kDa 3 |
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| | Search outside databases for aliases for TAF1D genePrevious GC identifer: GC11M093183 |
Summaries for TAF1D(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TAF1D_HUMAN, Q9H5J8Function: Component of the transcription factor SL1/TIFIB complex involved in the assembly of the PIC (preinitiation complex) |
Genomic Location for TAF1D
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21TAF1D Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M093195:
(about GC identifiers)
Start:
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93,103,017 bp from pter |
End:
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93,114,310 bp from pter |
Size:
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11,294 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000011.8 NT_008984.17
| Proteins for TAF1D
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAF1D_HUMAN, Q9H5J8 (See
protein sequence)Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit D Size: 278 amino acids; 32058 Da
Subunit: Component of the transcription factor SL1/TIFIB complex which is composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex, interacts directly with TBP, TAF1A, TAF1B and TAF1C. Interaction of the SL1/TIFIB subunits with TBP excludes interaction with the transcription factor IID (TFIID) subunits. This mutually exclusive binding directs the formation of promoter and RNA polymerase-selective TBP-TAF complexes
Subcellular location: Nucleus
Secondary accessions: Q6I9Y6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_077021.1
ENSEMBL proteins: ENSP00000314971 ENSP00000376944
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for TAF1D: Assays for TAF1D: | Protein
Domains/ Families for TAF1D(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9H5J8 | Gene Function for TAF1D
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024116
Applied Biosystems Silencer® siRNAs for TAF1D
Sigma-Aldrich siRNA for TAF1D  Sigma-Aldrich shRNA for TAF1D  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024116                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024116                                  untagged cDNA clone in CMV expression vector: NM_024116 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024116
UniProtKB/Swiss-Prot: TAF1D_HUMAN, Q9H5J8Function: Component of the transcription factor SL1/TIFIB complex involved in the assembly of the PIC (preinitiation complex)1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for TAF1D
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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1 Interacting protein for TAF1D (ENSP000003149713 Q9H5J81) via UniProtKB, MINT, and/or STRINGAbout this table
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Drugs & Compounds for TAF1D(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for TAF1D
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Transcripts for TAF1D(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024116
Sigma-Aldrich siRNA for TAF1D  Sigma-Aldrich shRNA for TAF1D  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_024116 REFSEQ mRNAs for TAF1D gene: NM_024116.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024116               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024116                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024116                                  untagged cDNA clone in CMV expression vector: NM_024116  Additional cDNA sequence: AF086435.1 AK057183.1 CR457369.1 CR609260.1 24/31 DOTS entries (see all 31
): DT.86854061 DT.406975 DT.70100314 DT.86836428 DT.92449371 DT.95360426 DT.100028608 DT.120738161 DT.97846568 DT.95360424 DT.40108354 DT.100751145 DT.100774278 DT.100773939 DT.95360435 DT.100816148 DT.100028613 DT.100705466 DT.100799894 DT.75140193 DT.92449370 DT.100698516 DT.120738126 DT.120738140 24/305 AceView cDNA sequences (see all 305
):CR609260 BX476682 AA367799 AA748153 AI924962 AA810224 AW135413 BQ774057 AI928259 AA593582 AW410368 AA811355 CB158271 AW805766 BQ773263 T80408 BQ013392 CB138096 AK128061 BQ879138 AA279839 BU678795 BQ015041 CB159880 Unigene Cluster for TAF1D: TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa Hs.355750 [show with all ESTs]Unigene Representative Sequence: AK057183
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TAF1D (see all 11
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | - |   | |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 13a | · | 13b | ^ | 14 | |
| SP1: | |   | |   | |   | |
| SP2: | |   | - |   | |   | |
| SP3: | |   | |   | |   | |
| SP4: | |   | - |   | |   | |
| SP5: | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TAF1D
2 Ensembl transcripts including schematic representations: ENST00000323981
ENST00000393259
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Expression for TAF1D
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAF1D expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAF1D
1 / 2 10 probe-sets matching TAF1D gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAATTCCTCG
SOURCE GeneReport for Unigene cluster: Hs.355750
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Orthologs for TAF1D
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for TAF1D gene from 5/6 species (see all 6
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About this table Species with no ortholog for TAF1D
ENSEMBL Gene Tree for TAF1D | Paralogs for TAF1D(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
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SNPs/Variants for TAF1D(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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The following additional 42 SNP(s) have been
found in Applied Biosystems data source: (Click
for
Applied Biosystems TaqMan ® Genotyping Assay)
HapMap Linkage Disequilibrium images for TAF1D (up to first 250kb)
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Disorders & Mutations for TAF1D
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 612823
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Medical News for TAF1D(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for TAF1D (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for TAF1D gene:- A novel nuclear protein, MGC5306 interacts with DNA polymerase beta and has a potential role in cellular phenotype. (PubMed id 15520167)1, 2, 3, 4 Wang L....Banerjee S. (2004)
- A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. (PubMed id 17318177)2, 3, 4 Gorski J.J....Zomerdijk J.C. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)3 Stelzl U....Wanker E.E. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
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Search for TAF1D
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TAF1D
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAF1D
(According to HUGE)
About This Section
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Specialized Databases showing TAF1D(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for TAF1D(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for TAF1D:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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