Free for academic non-profit institutions. Other users need a Commercial license

Aliases for JOSD2 Gene

Aliases for JOSD2 Gene

  • Josephin Domain Containing 2 2 3
  • Josephin Domain-Containing Protein 2 3 4
  • EC 4
  • Josephin-2 3
  • SBBI54 3

External Ids for JOSD2 Gene

Summaries for JOSD2 Gene

Entrez Gene Summary for JOSD2 Gene

  • This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JOSD2 Gene

JOSD2 (Josephin Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-specific protease activity and omega peptidase activity. An important paralog of this gene is JOSD1.

UniProtKB/Swiss-Prot for JOSD2 Gene

  • Cleaves Lys-63-linked poly-ubiquitin chains, and with lesser efficiency Lys-48-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JOSD2 Gene

Genomics for JOSD2 Gene

Genomic Location for JOSD2 Gene

50,505,997 bp from pter
50,511,355 bp from pter
5,359 bases
Minus strand

Genomic View for JOSD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JOSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JOSD2 Gene

Regulatory Elements for JOSD2 Gene

Proteins for JOSD2 Gene

  • Protein details for JOSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • M0QX25

    Protein attributes for JOSD2 Gene

    188 amino acids
    Molecular mass:
    20756 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JOSD2 Gene


neXtProt entry for JOSD2 Gene

Proteomics data for JOSD2 Gene at MOPED

Post-translational modifications for JOSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JOSD2 Gene

No data available for DME Specific Peptides for JOSD2 Gene

Domains for JOSD2 Gene

Protein Domains for JOSD2 Gene



  • Contains 1 Josephin domain.:
    • Q8TAC2
genes like me logo Genes that share domains with JOSD2: view

No data available for Gene Families for JOSD2 Gene

Function for JOSD2 Gene

Molecular function for JOSD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function: Cleaves Lys-63-linked poly-ubiquitin chains, and with lesser efficiency Lys-48-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

Enzyme Numbers (IUBMB) for JOSD2 Gene

Gene Ontology (GO) - Molecular Function for JOSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 ubiquitin-specific protease activity IDA 21118805
GO:0008242 omega peptidase activity IEA --
genes like me logo Genes that share ontologies with JOSD2: view
genes like me logo Genes that share phenotypes with JOSD2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for JOSD2 Gene

Localization for JOSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JOSD2 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for JOSD2 Gene COMPARTMENTS Subcellular localization image for JOSD2 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for JOSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with JOSD2: view

Pathways for JOSD2 Gene

SuperPathways for JOSD2 Gene

No Data Available

Interacting Proteins for JOSD2 Gene

Selected Interacting proteins: Q8TAC2-JOS2_HUMAN for JOSD2 Gene via I2D

Gene Ontology (GO) - Biological Process for JOSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0016579 protein deubiquitination IDA 21118805
genes like me logo Genes that share ontologies with JOSD2: view

No data available for Pathways by source for JOSD2 Gene

Transcripts for JOSD2 Gene

Unigene Clusters for JOSD2 Gene

Josephin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JOSD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -

Relevant External Links for JOSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JOSD2 Gene

mRNA expression in normal human tissues for JOSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for JOSD2 Gene

SOURCE GeneReport for Unigene cluster for JOSD2 Gene Hs.467151

genes like me logo Genes that share expressions with JOSD2: view

Orthologs for JOSD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JOSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia JOSD2 37
  • 87 (a)
(Bos Taurus)
Mammalia JOSD2 37
  • 87 (a)
LOC100848343 36
  • 91.84 (n)
  • 96.28 (a)
(Canis familiaris)
Mammalia JOSD2 36
  • 93.05 (n)
  • 96.79 (a)
JOSD2 37
  • 87 (a)
(Mus musculus)
Mammalia Josd2 36
  • 86.88 (n)
  • 94.68 (a)
Josd2 16
Josd2 37
  • 95 (a)
(Rattus norvegicus)
Mammalia Josd2 36
  • 86.17 (n)
  • 93.09 (a)
(Anolis carolinensis)
Reptilia JOSD2 37
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia josd2 36
  • 64.2 (n)
  • 62.5 (a)
Str.6100 36
(Danio rerio)
Actinopterygii josd2 36
  • 62.94 (n)
  • 63.69 (a)
josd2 37
  • 62 (a)
zgc55937 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005226 36
  • 52.38 (n)
  • 46.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3781 36
  • 57.65 (n)
  • 51.76 (a)
CG3781 37
  • 40 (a)
(Caenorhabditis elegans)
Secernentea josd-1 37
  • 38 (a)
Y71H2AR.3 36
  • 46.75 (n)
  • 42.07 (a)
Species with no ortholog for JOSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JOSD2 Gene

Gene Tree for JOSD2 (if available)
Gene Tree for JOSD2 (if available)

Paralogs for JOSD2 Gene

Paralogs for JOSD2 Gene

Selected SIMAP similar genes for JOSD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JOSD2: view

Variants for JOSD2 Gene

Sequence variations from dbSNP and Humsavar for JOSD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1150919 -- 50,510,708(-) GGACC(C/T)TTTTA intron-variant
rs1274623 -- 50,510,734(-) CCTCT(C/G)TTGCT intron-variant
rs1274698 -- 50,509,559(+) GATGC(A/G)GAGGC intron-variant
rs3786677 -- 50,507,360(+) TCCAA(C/T)GGCCT intron-variant
rs4802713 -- 50,509,883(+) CCCGT(C/T)TCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JOSD2 Gene

Variant ID Type Subtype PubMed ID
nsv912282 CNV Loss 21882294
nsv509750 CNV Insertion 20534489
nsv912283 CNV Gain 21882294
nsv912284 CNV Loss 21882294

Relevant External Links for JOSD2 Gene

HapMap Linkage Disequilibrium report

Disorders for JOSD2 Gene

Relevant External Links for JOSD2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with JOSD2: view

No data available for UniProtKB/Swiss-Prot for JOSD2 Gene

Publications for JOSD2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. (PMID: 21118805) Weeks S.D. … Loll P.J. (J. Biol. Chem. 2011) 3 4
  3. JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. (PMID: 23625928) Seki T. … Paulson H.L. (J. Biol. Chem. 2013) 3 4
  4. Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes. (PMID: 17696782) Tzvetkov N. … Breuer P. (Biol. Chem. 2007) 3 4
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for JOSD2 Gene

  • Addgene plasmids for JOSD2

Sources for JOSD2 Gene

Back to Top