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Aliases for JOSD2 Gene

Aliases for JOSD2 Gene

  • Josephin Domain Containing 2 2 3 5
  • Josephin Domain-Containing Protein 2 3 4
  • EC 4
  • SBBI54 3

External Ids for JOSD2 Gene

Previous GeneCards Identifiers for JOSD2 Gene

  • GC19M055702
  • GC19M051009
  • GC19M047345

Summaries for JOSD2 Gene

Entrez Gene Summary for JOSD2 Gene

  • This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JOSD2 Gene

JOSD2 (Josephin Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include thiol-dependent ubiquitin-specific protease activity and omega peptidase activity. An important paralog of this gene is JOSD1.

UniProtKB/Swiss-Prot for JOSD2 Gene

  • Cleaves Lys-63-linked poly-ubiquitin chains, and with lesser efficiency Lys-48-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JOSD2 Gene

Genomics for JOSD2 Gene

Regulatory Elements for JOSD2 Gene

Enhancers for JOSD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JOSD2 on UCSC Golden Path with GeneCards custom track

Promoters for JOSD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JOSD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for JOSD2 Gene

50,505,997 bp from pter
50,511,355 bp from pter
5,359 bases
Minus strand

Genomic View for JOSD2 Gene

Genes around JOSD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JOSD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JOSD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JOSD2 Gene

Proteins for JOSD2 Gene

  • Protein details for JOSD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • M0QX25

    Protein attributes for JOSD2 Gene

    188 amino acids
    Molecular mass:
    20756 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JOSD2 Gene


neXtProt entry for JOSD2 Gene

Proteomics data for JOSD2 Gene at MOPED

Post-translational modifications for JOSD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JOSD2 Gene

No data available for DME Specific Peptides for JOSD2 Gene

Domains & Families for JOSD2 Gene

Gene Families for JOSD2 Gene

Protein Domains for JOSD2 Gene


Suggested Antigen Peptide Sequences for JOSD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Josephin domain.
  • Contains 1 Josephin domain.
genes like me logo Genes that share domains with JOSD2: view

Function for JOSD2 Gene

Molecular function for JOSD2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
UniProtKB/Swiss-Prot Function:
Cleaves Lys-63-linked poly-ubiquitin chains, and with lesser efficiency Lys-48-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme.

Enzyme Numbers (IUBMB) for JOSD2 Gene

genes like me logo Genes that share phenotypes with JOSD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JOSD2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JOSD2 Gene

Localization for JOSD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JOSD2 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for JOSD2 Gene COMPARTMENTS Subcellular localization image for JOSD2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for JOSD2 Gene

Pathways & Interactions for JOSD2 Gene

SuperPathways for JOSD2 Gene

No Data Available

Interacting Proteins for JOSD2 Gene

Selected Interacting proteins: Q8TAC2-JOS2_HUMAN for JOSD2 Gene via I2D

Gene Ontology (GO) - Biological Process for JOSD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016579 protein deubiquitination IDA 21118805
genes like me logo Genes that share ontologies with JOSD2: view

No data available for Pathways by source and SIGNOR curated interactions for JOSD2 Gene

Drugs & Compounds for JOSD2 Gene

No Compound Related Data Available

Transcripts for JOSD2 Gene

Unigene Clusters for JOSD2 Gene

Josephin domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JOSD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: -

Relevant External Links for JOSD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JOSD2 Gene

mRNA expression in normal human tissues for JOSD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JOSD2 Gene

This gene is overexpressed in Spinal cord (14.9), Frontal cortex (13.4), and Bone marrow stromal cell (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for JOSD2 Gene

SOURCE GeneReport for Unigene cluster for JOSD2 Gene Hs.467151

genes like me logo Genes that share expression patterns with JOSD2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for JOSD2 Gene

Orthologs for JOSD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JOSD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100848343 35
  • 91.84 (n)
  • 96.28 (a)
JOSD2 36
  • 87 (a)
(Canis familiaris)
Mammalia JOSD2 35
  • 93.05 (n)
  • 96.79 (a)
JOSD2 36
  • 87 (a)
(Mus musculus)
Mammalia Josd2 35
  • 86.88 (n)
  • 94.68 (a)
Josd2 16
Josd2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Josd2 35
  • 86.17 (n)
  • 93.09 (a)
(Pan troglodytes)
Mammalia JOSD2 36
  • 87 (a)
(Anolis carolinensis)
Reptilia JOSD2 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia josd2 35
  • 64.2 (n)
  • 62.5 (a)
Str.6100 35
(Danio rerio)
Actinopterygii josd2 35
  • 62.94 (n)
  • 63.69 (a)
zgc55937 35
josd2 36
  • 62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005226 35
  • 52.38 (n)
  • 46.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3781 35
  • 57.65 (n)
  • 51.76 (a)
CG3781 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AR.3 35
  • 46.75 (n)
  • 42.07 (a)
josd-1 36
  • 38 (a)
Species with no ortholog for JOSD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JOSD2 Gene

Gene Tree for JOSD2 (if available)
Gene Tree for JOSD2 (if available)

Paralogs for JOSD2 Gene

Paralogs for JOSD2 Gene

(2) SIMAP similar genes for JOSD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JOSD2: view

Variants for JOSD2 Gene

Sequence variations from dbSNP and Humsavar for JOSD2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7256407 -- 50,507,239(+) TGCCC(A/G)GCCAC intron-variant
rs7257447 -- 50,507,234(+) CCACA(C/T)GCCCA intron-variant
rs7257671 -- 50,507,435(+) CCCTT(C/T)CAACC intron-variant
rs139922747 -- 50,508,667(+) GGACC(C/T)TGGGC intron-variant
rs34345488 -- 50,509,104(+) AGTGA(-/TT)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JOSD2 Gene

Variant ID Type Subtype PubMed ID
nsv912282 CNV Loss 21882294
nsv509750 CNV Insertion 20534489
nsv912283 CNV Gain 21882294
nsv912284 CNV Loss 21882294

Variation tolerance for JOSD2 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for JOSD2 Gene

Disorders for JOSD2 Gene

Relevant External Links for JOSD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JOSD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JOSD2 Gene

Publications for JOSD2 Gene

  1. JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. (PMID: 23625928) Seki T. … Paulson H.L. (J. Biol. Chem. 2013) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. (PMID: 21118805) Weeks S.D. … Loll P.J. (J. Biol. Chem. 2011) 3
  4. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PMID: 22118674) Altun M. … Kessler B.M. (Chem. Biol. 2011) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for JOSD2 Gene

Sources for JOSD2 Gene