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JOSD2 Gene

protein-coding   GIFtS: 40

GC19M055702
Josephin domain containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for JOSD2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ29018 2
SBBI54 1, 2
Descriptions
Josephin domain containing 2 2
Josephin domain-containing protein 2 3
External Ids
HGNC: 288531
Entrez Gene: 1261192
UniProtKB: Q8TAC23
Ensembl: ENSG000001616777
Search outside databases for aliases for JOSD2 gene

Summaries
for JOSD2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for JOSD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the JOSD2 gene  

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

JOSD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055702:     (about GC identifiers)

Start:
 55,701,067 bp from pter
End:
 55,706,231 bp from pter
Size:
 5,165 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for JOSD2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2 (See protein sequence)
Recommended Name: Josephin-2  
Size: 188 amino acids; 20756 Da

REFSEQ proteins: NP_612207.1  

ENSEMBL proteins: 
ENSP00000293431 ENSP00000375691 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for JOSD2: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for JOSD2

Assays for JOSD2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for JOSD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR006155 Josephin


   GeneDecks  JOSD2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8TAC2

ProtoNet protein and cluster: Q8TAC2

UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2
Similarity: Contains 1 Josephin domain

Gene Function
for JOSD2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138334

              Applied Biosystems Silencer® siRNAs for JOSD2

              Sigma-Aldrich siRNA for JOSD2  
                     Sigma-Aldrich shRNA for JOSD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for JOSD2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138334
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138334
                                 untagged cDNA clone in CMV expression vector: NM_138334 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_138334

Pathways & Interactions
for JOSD2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for JOSD2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JOSD2

Transcripts
for JOSD2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_138334

              Sigma-Aldrich siRNA for JOSD2  
                     Sigma-Aldrich shRNA for JOSD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_138334  

REFSEQ mRNAs for JOSD2 gene: 

NM_138334.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_138334  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138334
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138334
                                 untagged cDNA clone in CMV expression vector: NM_138334 

Additional cDNA sequence: 

AF247787.1 AK131052.1 BC051380.1 BC062416.1 

4 DOTS entries:

DT.448065  DT.99954069  DT.97782290  DT.99963681 

24/85 AceView cDNA sequences (see all 85 ):

BQ083148 CA418805 CB157309 BU623847 BQ062311 BM792044 BQ924400 CN485251 
BQ575045 BC062416 BM694260 BM474974 BM790832 BQ268256 BU624373 BQ061012 
BM970016 BF033739 AW444593 BE261354 CA425740 BE906132 AI051130 BU509078 

highest scoring ESTs for JOSD2:

AA424087 AA448739 AF247787 AI218850 BC051380 BC062416 BE261354 BE279986 BE903777 BE906132 

Unigene Cluster for JOSD2:

Josephin domain containing 2
Hs.467151  [show with all ESTs]
Unigene Representative Sequence: BQ890790


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for JOSD2 (see all 6 )

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1:                                -           -                                       
SP2:                                -           -                                       
SP3:                                -           -     -                                 
SP4:                          -     -           -                                       
SP5:                                            -                                       

About this scheme

ECgene alternative splicing isoforms for JOSD2

2 Ensembl transcripts including schematic representations:
ENST00000293431  ENST00000391815  

Expression
for JOSD2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JOSD2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for JOSD2

1 / 2 / 3

3 probe-sets matching JOSD2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
59383_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI218850 0.80 1.00 0.91 1

227096_at2, 3 U133-B 1 1.00 1.00 -- -- AI218850 0.80 1.00 0.91 1

227096_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  JOSD2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GACCCTGGGG

SOURCE GeneReport for Unigene cluster: Hs.467151

Orthologs
for JOSD2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for JOSD2 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 JOSD21   -- Josephin domain containing 2 93.05(n)
96.79(a)		 611845  XM_849567.1  XP_854660.1 
cow
(Bos taurus)		 JOSD21   -- Josephin domain containing 2 91.84(n)
96.28(a)		 533909  XM_613472.3  XP_613472.3 
rat
(Rattus norvegicus)		 Josd21   -- Josephin domain containing 2 86.45(n)
93.58(a)		 292876  XM_214929.4  XP_214929.1 
mouse
(Mus musculus)		 Josd21, 5 75
 Josephin domain containing 21, 5 86.99(n)1
95.19(a)1		 661241  NM_025368.21  NP_079644.11 
 AI8461655  AK0028725  (see all 8)
zebrafish
(Danio rerio)		 zgc559372   -- hypothetical protein MGC55937 75.78(n) 393120  BC044546.1 
About this table        Species with no ortholog for JOSD2

ENSEMBL Gene Tree for JOSD2

Paralogs
for JOSD2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for JOSD2 gene
JOSD12  

SNPs/Variants
for JOSD2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/44 NCBI SNPs in JOSD2 are shown (see all 44 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 41)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs77191,2
C,F55701132(-) GCCCCG/ACCCCC 1 -- ut312Minor allele frequency- A:0.30EA MN 1284
rs30875821,2
F55701203(+) GGATGC/TGCAGG 1 -- ut31 ese31Minor allele frequency- T:0.27MN 184
rs116727431,2
A,C,F,H55703685(+) CACTTG/CTCTCT 1 -- int18Minor allele frequency- C:0.22EU EA WA 838
rs37866771,2
A,C,F,H55702429(+) TCCAAC/TGGCCT 1 -- int113Minor allele frequency- T:0.29EA NA EU WA 2534
rs12746981,2
C,F,H55704628(+) GATGCA/GGAGGC 1 -- int15Minor allele frequency- G:0.45MN EU EA WA 596
rs11509191,2
C55705777(-) GGACCC/TTTTTA 1 -- int11Minor allele frequency- T:0.00MN 184
--
rs72564071,2
A55702308(+) TGCCCA/GGCCAC 1 -- int10--------
--
rs72576711,2
A55702504(+) CCCTTC/TCAACC 1 -- int1 trp30--------
--
rs72574471,2
A55702303(+) CCACAC/TGCCCA 1 -- int10--------
--
rs48027131,2
C55704952(+) cccgtC/Ttctac 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for JOSD2 (up to first 250kb)

Disorders & Mutations
for JOSD2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for JOSD2

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for JOSD2

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

4 PubMed articles for JOSD2 gene:

Search for JOSD2

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing JOSD2

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 126119 HGNC: 28853 AceView: SBBI54 Ensembl:ENSG00000161677 euGenes: HUgn126119
ECgene: JOSD2 H-InvDB: JOSD2

Other Databases showing JOSD2

(According to HUGE)
About This Section

   --

Specialized Databases showing JOSD2

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for JOSD2

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for JOSD2

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for JOSD2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for JOSD2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


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