JOSD2 Gene
protein-coding GIFtS: 43
GCID: GC19M051009
|
|
Josephin domain containing 2
| |
Aliases
for JOSD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Josephin Domain Containing 21 2 | | Josephin Domain-Containing Protein 22 3 | | SBBI541 | | Josephin-22 | | EC 3.4.19.123 |
Export aliases for JOSD2 gene to outside databasesPrevious GC identifers: GC19M055702 GC19M047345 |
Summaries
for JOSD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JOSD2:
This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinatingenzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and proteinsubstrates. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.(provided by RefSeq, Jul 2012)
UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2Function: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitinchains (in vitro). May act as a deubiquitinating enzyme
|
Genomic Views
for JOSD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JOSD2 gene promoter:
AML1a Pax-5 NRSF form 1 AP-2gamma NRSF form 2 YY1 Egr-4 PPAR-alpha ZIC2/Zic2 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for JOSD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JOSD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33JOSD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M051009: view genomic region
(about GC identifiers)
Start:
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51,009,259 bp from pter |
End:
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51,014,345 bp from pter |
Size:
|
5,087 bases |
Orientation:
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minus strand |
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Proteins
for JOSD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2 (See
protein sequence)Recommended Name: Josephin-2 Size: 188 amino acids; 20756 DaExplore the universe of human proteins at neXtProt for JOSD2: NX_Q8TAC2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAC2
JOSD2 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (5 alternative transcripts):
NP_001257568.1 NP_001257569.1 NP_001257570.1 NP_001257615.1 NP_612207.1
ENSEMBL proteins: ENSP00000375691
Human Recombinant Protein Products:
JOSD2 Antibody Products:
Assay Products for JOSD2: |
Protein
Domains /
Families
for JOSD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JOSD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TAC2ProtoNet protein and cluster: Q8TAC2 UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2Similarity: Contains 1 Josephin domain |
Function
for JOSD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JOS2_HUMAN, Q8TAC2Function: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitinchains (in vitro). May act as a deubiquitinating enzymeCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.121
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD2
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004843 | ubiquitin-specific protease activity |
IDA | -- | | GO:0008242 | omega peptidase activity |
IEA | -- |
JOSD2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for JOSD2:
|
Pathways & Interactions
for JOSD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JOSD2
5 Interacting proteins for JOSD2 (Q8TAC23) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0016579 | protein deubiquitination |
IDA | -- |
JOSD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for JOSD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JOSD2
Search CenterWatch for drugs/clinical trials and news about JOSD2 / JOS2
|
Transcripts
for JOSD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JOSD2 gene (5 alternative transcripts): NM_001270639.1 NM_001270640.1 NM_001270641.1 NM_001270686.1 NM_138334.3 Unigene Clusters for JOSD2: Josephin domain containing 2 Hs.467151 [show with all ESTs], Hs.737597 [show with all ESTs]Unigene Representative Sequences: NM_001270639, BQ8907901 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000391815(uc002psn.1 uc002psp.1 uc002pso.1 uc002psq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JOSD2 (NM_138334) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK131052.1 4 DOTS entries: DT.448065 DT.99954069 DT.97782290 DT.99963681 24/85 AceView cDNA sequences (see all 85): BQ924400 CN485251 BU624373 BQ268256 BM474974 BQ083148 BM694260 BQ575045 BU623847 BQ062311 CA418805 CB157309 BC062416 BM790832 BM792044 BX501721 BE906132 BU509078 BV177102 CD636376 BX283124 BQ576058 NM_138334 AK131052
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for JOSD2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
|---|
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| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for JOSD2
|
Expression
for JOSD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JOSD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCCTGGGG
About this image
Genevestigator expression for JOSD2
SOURCE GeneReport for Unigene clusters: Hs.467151 Hs.737597
SABiosciences Custom PCR Arrays for JOSD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JOSD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JOSD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JOSD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JOSD2 |
Orthologs
for JOSD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for JOSD2 gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for JOSD2 (if available)
TreeFam Gene Tree for JOSD2 (if available) |
Paralogs
for JOSD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JOSD2 gene
- JOSD12
2 SIMAP similar genes for JOSD2 using alignment to 4 protein entries: JOS2_HUMAN (see all proteins):KIAA0063 JOSD1
JOSD2 for paralogs About GeneDecksing
|
Genomic Variants
for JOSD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JOSD2 (51009259 - 51014345 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for JOSD2
3 Indels: 89290 78240 78241 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JOSD2 |
|
Disorders
/ Diseases
for JOSD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for JOSD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JOSD2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with JOSD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structure of a Josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity. (PubMed id 21118805)1, 2 Weeks S.D.... Loll P.J. (2011)
- Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes. (PubMed id 17696782)1, 2 Tzvetkov N. and Breuer P. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Cytokine-regulated protein degradation by the ubiquit ination system. (PubMed id 16611142)1 Baek K.H. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Structural modeling of ataxin-3 reveals distant homology to adaptins. (PubMed id 12486728)2 Albrecht M....Lengauer T. (2003)
|
External Searches for JOSD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JOSD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JOSD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JOSD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JOSD2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for JOSD2 gene:
Search GeneIP for patents involving JOSD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JOSD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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