JOSD1 Gene
protein-coding GIFtS: 45
GCID: GC22M039081
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|
Josephin domain containing 1
| |
Aliases
for JOSD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Josephin Domain Containing 11 2 | | DJ508I15.21 | | KIAA00631 3 | | EC 3.4.19.123 | | Josephin Domain-Containing 12 3 | | JSPH13 | | Josephin-12 | | |
Export aliases for JOSD1 gene to outside databasesPrevious GC identifers: GC22M037407 GC22M022047 |
Summaries
for JOSD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040Function: Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme
|
Genomic Views
for JOSD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JOSD1 gene promoter:
STAT1 STAT1beta LCR-F1 Evi-1 STAT1alpha N-Myc POU2F1 CP2 POU2F1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for JOSD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JOSD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1JOSD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M039081: view genomic region
(about GC identifiers)
Start:
|
39,081,548 bp from pter |
End:
|
39,097,561 bp from pter |
Size:
|
16,014 bases |
Orientation:
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minus strand |
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Proteins
for JOSD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040 (See
protein sequence)Recommended Name: Josephin-1 Size: 202 amino acids; 23198 Da
Sequence caution: Sequence=BAA06682.2; Type=Erroneous initiation;
Secondary accessions: A8K712Explore the universe of human proteins at neXtProt for JOSD1: NX_Q15040
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15040
JOSD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055691.1
ENSEMBL proteins: ENSP00000216039 ENSP00000444798 ENSP00000410010 ENSP00000415189 ENSP00000393131 ENSP00000405182
Human Recombinant Protein Products:
JOSD1 Antibody Products:
Assay Products for JOSD1: |
Protein
Domains /
Families
for JOSD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JOSD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15040ProtoNet protein and cluster: Q15040 UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040Similarity: Contains 1 Josephin domain |
Function
for JOSD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040Function: Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzymeCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for JOSD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JOSD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JOSD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008242 | omega peptidase activity |
IEA | -- |
JOSD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for JOSD1:
|
Pathways & Interactions
for JOSD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JOSD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/9 Interacting proteins for JOSD1 (Q150403 ENSP000002160394) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
JOSD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for JOSD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JOSD1
Search CenterWatch for drugs/clinical trials and news about JOSD1 / JOS1
|
Transcripts
for JOSD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JOSD1 gene: NM_014876.5 Unigene Cluster for JOSD1: Josephin domain containing 1 Hs.3094 [show with all ESTs]Unigene Representative Sequence: NM_01487610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216039(uc003awf.3) ENST00000545590 ENST00000482442 ENST00000427389
ENST00000412832 ENST00000417712 ENST00000456626 ENST00000462610 ENST00000490169
ENST00000493939
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JOSD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JOSD1 (NM_014876) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JOSD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JOSD1 |
Additional cDNA sequence: AK291827.1 BC015026.2 BX538323.1 CR456473.1 CR456923.1 D31884.1 14 DOTS entries: DT.454568 DT.100645098 DT.95171932 DT.100893826 DT.95178630 DT.100893829 DT.120671404 DT.120671397 DT.91765621 DT.100652028 DT.120671398 DT.120671410 DT.65286679 DT.95171929 24/308 AceView cDNA sequences (see all 308): BQ024917 AW173459 CA444340 BQ638591 CA503247 AL039248 CR456473 AI375381 BQ880930 AI200974 BM984237 AI521636 AI783803 BM789347 AW139327 AA347007 BX284036 D31884 BM800179 AW613896 BM971330 AI452808 AI867758 BQ929893
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for JOSD1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
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| SP1: | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for JOSD1
|
Expression
for JOSD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JOSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGATGCCCA
About this image
See JOSD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JOSD1
SOURCE GeneReport for Unigene cluster: Hs.3094
SABiosciences Custom PCR Arrays for JOSD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JOSD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat JOSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JOSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JOSD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JOSD1 |
Orthologs
for JOSD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for JOSD1 gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for JOSD1 (if available)
TreeFam Gene Tree for JOSD1 (if available) |
Paralogs
for JOSD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JOSD1 gene
- JOSD22
2 SIMAP similar genes for JOSD1 using alignment to 6 protein entries: JOS1_HUMAN (see all proteins):KIAA0063 JOSD2
JOSD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for JOSD1
PGOHUM00000245282
|
Genomic Variants
for JOSD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JOSD1 (39081548 - 39097561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for JOSD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JOSD1 |
|
Disorders
/ Diseases
for JOSD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for JOSD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JOSD1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with JOSD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N....Tabata S. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Structural modeling of ataxin-3 reveals distant homology to adaptins. (PubMed id 12486728)1, 2 Albrecht M....Lengauer T. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
- Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for JOSD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JOSD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JOSD1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing JOSD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JOSD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for JOSD1 gene:
Search GeneIP for patents involving JOSD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JOSD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for JOSD1 | | OriGene Custom Protein Services for JOSD1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JOSD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JOSD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JOSD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JOSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JOSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JOSD1 |
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 | | | JOSD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JOSD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for JOSD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JOSD1 |
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