JOSD1 Gene

Aliases
for JOSD1 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC22M037407 GC22M022047

Summaries
for JOSD1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for JOSD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000022.10  NT_011520.13  NC_018933.2  

SwitchGear Promoter luciferase reporter plasmid: JOSD1 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JOSD1

JOSD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M039081:  view genomic region     (about GC identifiers)

Proteins
for JOSD1 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for JOSD1: NX_Q15040

Explore proteomics data for JOSD1 at MOPED

Post-translational modifications: 

JOSD1 Human Recombinant Protein Products:

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Domains /
Families
for JOSD1 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q15040

Find genes that share domains with JOSD1           About GenesLikeMe

Function
for JOSD1 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 3.4.19.12¹

     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for JOSD1

miRNA Products:		miRTarBase miRNAs that target JOSD1: hsa-mir-186-5p (MIRT045025), hsa-mir-26b-5p (MIRT029639)
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		Selected qRT-PCR Assays for microRNAs that regulate JOSD1 (see all 96):
		hsa-miR-520e hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-298 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: JOSD1 3' UTR sequence

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JOSD1

Localization
for JOSD1 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
nucleus	2
extracellular	1
mitochondrion	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for JOSD1 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for JOSD1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for JOSD1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for JOSD1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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JOSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGATGCCCA

About this image

Bone (Muscoskeletal System)
Bone Marrow

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JOSD1

Orthologs
for JOSD1 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for JOSD1 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for JOSD1 gene

JOSD2²  

2 SIMAP similar genes for JOSD1 using alignment to 6 protein entries:     JOS1_HUMAN (see all proteins):

KIAA0063    JOSD2

Find genes that share paralogs with JOSD1           About GenesLikeMe


1 Pseudogenes.org Pseudogene for JOSD1
PGOHUM00000245282

Genomic Variants
for JOSD1 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for JOSD1 (see all 339)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1453636821,2		--	39081350(+)	CAGTGC/TGGTAC	1	--	ds5001		0	--	--	--	--
rs1491795501,2		--	39081471(+)	CTATTC/TTGTCT	1	--	ds5001		0	--	--	--	--
rs1442029661,2	C	--	39081621(+)	GAGAC-/ATATATG	1	--	ut31		0	--	--	--	--
rs1430853441,2	C	--	39081633(+)	GAGTTG/TTCCAT	1	--	ut31		0	--	--	--	--
rs1873967901,2		--	39081647(+)	TAATAC/TTTGGT	1	--	ut31		0	--	--	--	--
rs1931180041,2		--	39081806(+)	GCCCTG/TGGGCA	1	--	ut31		0	--	--	--	--
rs1150009581,2	C,F	--	39081842(+)	ACCAGA/GATTGG	1	--	ut31		1		WA	118
rs1385851201,2		--	39082027(+)	GTGGCC/TCCAAG	1	--	ut31		0	--	--	--	--
rs57572431,2	H	--	39082043(+)	GCTTGT/AGACAA	1	--	ut31 ese3		4		NS EA	418
rs1123952951,2	C,F	--	39082169(+)	GACTGC/TGGCCA	1	--	ut31		1		CSA	2

HapMap Linkage Disequilibrium report for JOSD1 (39081548 - 39097561 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for JOSD1:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv915067	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing JOSD1

DNA2.0 Custom Variant and Variant Library Synthesis for JOSD1

Disorders / Diseases
for JOSD1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for JOSD1 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for JOSD1 gene, integrated from 10 sources (see all 25): (articles sorted by number of sources associating them with JOSD1)

Utopia: connect your pdf to the dynamic world of online information

1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2, 3} Nomura N.... Tabata S. (DNA Res. 1994)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
4. Structural modeling of ataxin-3 reveals distant homology to adaptins. (PubMed id 12486728)^{1, 2} Albrecht M....Lengauer T. (Proteins 2003)
5. The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I.... Wright H. (Nature 1999)
6. JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. (PubMed id 23625928)² Seki T.... Paulson H.L. (J. Biol. Chem. 2013)
7. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
8. A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)¹ Loch C.M. and Strickler J.E. (Biochim. Biophys. Acta 2012)
9. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)¹ Guo Z....Gao Y. (J. Proteome Res. 2012)
10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

External Searches for JOSD1 gene

Genome Databases showing JOSD1 gene

Other Databases showing JOSD1 gene

Specialized Databases showing JOSD1 gene

Products
for JOSD1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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