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Set Analyses:

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JOSD1 Gene

protein-coding GIFtS: 51
GCID: GC22M039081

Josephin Domain Containing 1

Search for JOSD1
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Josephin Domain Containing 1¹ ²		dJ508I15.2²
Josephin Domain-Containing Protein 1² ³		Josephin Domain-Containing 1²
KIAA0063³ ⁵		EC 3.4.19.12³
Josephin-1²		JSPH1³

External Ids:	HGNC: 28953¹	Entrez Gene: 9929²	Ensembl: ENSG00000100221⁷	OMIM: 615323⁵	UniProtKB: Q15040³

Export aliases for JOSD1 gene to outside databases

Previous GC identifers: GC22M037407 GC22M022047

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JOSD1 Gene:

JOSD1 (Josephin domain containing 1) is a protein-coding gene. GO annotations related to this gene include omega peptidase activity. An important paralog of this gene is JOSD2.

UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040

Function: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and

'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase

macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell

motility independently of its catalytic activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000022.11 NT_011520.13 NC_018933.2

Regulatory elements:

Regulatory transcription factor binding sites in the JOSD1 gene promoter:
STAT1 STAT1beta LCR-F1 Evi-1 STAT1alpha N-Myc POU2F1 CP2 POU2F1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JOSD1 promoter sequence

Search Chromatin IP Primers for JOSD1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JOSD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

JOSD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JOSD1 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M039081: view genomic region (about GC identifiers)

Start:	39,081,548 bp from pter	End:	39,097,561 bp from pter
Size:	16,014 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040 (See protein sequence)

Recommended Name: Josephin-1

Size: 202 amino acids; 23198 Da

Subunit: Interacts with beta-actin/ACTB

Sequence caution: Sequence=BAA06682.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: A8K712

Explore the universe of human proteins at neXtProt for JOSD1: NX_Q15040

Explore proteomics data for JOSD1 at MOPED

Post-translational modifications:

Monoubiquitinated (By similarity). Ubiquitination activates deubiquitination activity in vitro¹

Ubiquitination² at Lys74, Lys180

Modification sites at PhosphoSitePlus

See JOSD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055691.1

ENSEMBL proteins:

ENSP00000216039 ENSP00000444798 ENSP00000410010 ENSP00000415189 ENSP00000393131

ENSP00000405182

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:

IPR006155 Josephin

Graphical View of Domain Structure for InterPro Entry Q15040

ProtoNet protein and cluster: Q15040

UniProtKB/Swiss-Prot: JOS1_HUMAN, Q15040

Similarity: Contains 1 Josephin domain

JOSD1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: JOS1_HUMAN, Q15040

Function: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and

'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase

macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell

motility independently of its catalytic activity

Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by

the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)

Enzyme Number (IUBMB): EC 3.4.19.12¹

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008242	omega peptidase activity	IEA	--

JOSD1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for JOSD1:

Decreased Wnt reporter activit

Animal Models:

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		Block miRNA regulation of human, mouse, rat JOSD1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate JOSD1 (see all 96):
		hsa-miR-520e hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-298 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: JOSD1 3' UTR sequence

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

JOS1_HUMAN, Q15040: Cell membrane. Cytoplasm. Note=Ubiquitination increases localization the plasma membrane. In

the cytosol, the unubiquinated form may be associated with the cytoskeleton via ACTB-binding

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	3
nucleus	2
extracellular	1
mitochondrion	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

JOSD1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for JOSD1
Interactions:

Search GeneGlobe Interaction Network for JOSD1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for JOSD1 (Q15040³ ENSP00000216039⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000215641	P14373³	I2D: score=1
ENSG00000229006	P14373³	I2D: score=1
ENSG00000234495	P14373³	I2D: score=1
ENSG00000237071	P14373³	I2D: score=1
TRIM27	P14373³	I2D: score=1

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	--	--

JOSD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for JOSD1 (JOS1)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for JOSD1 gene:

NM_014876.5

Unigene Cluster for JOSD1:

Josephin domain containing 1

Hs.3094 [show with all ESTs]

Unigene Representative Sequence: NM_014876

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216039(uc003awf.3) ENST00000545590 ENST00000482442 ENST00000427389

ENST00000412832 ENST00000417712 ENST00000456626 ENST00000462610 ENST00000490169

ENST00000493939

miRNA Products:		Block miRNA regulation of human, mouse, rat JOSD1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate JOSD1 (see all 96):
		hsa-miR-520e hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-30a hsa-miR-149 hsa-miR-298 hsa-miR-93

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		QuantiFast Probe-based Assays in human, mouse, rat JOSD1

Additional mRNA sequence:

AK291827.1 BC015026.2 BX538323.1 CR456473.1 CR456923.1 D31884.1

11 DOTS entries:

DT.454568 DT.100645098 DT.95171932 DT.95178630 DT.100893826 DT.120671404 DT.120671397 DT.91765621

DT.100893829 DT.65286679 DT.95171929

Selected AceView cDNA sequences (see all 308):

AI521636 AI867758 AA347008 BU542301 AW168411 AW630650 BQ775648 AI783803

BU625613 CR596979 BQ880930 AI200974 CA444340 AV708886 BQ929893 BG231784

BQ024917 AI471247 BE044627 AW613896 AA378680 BM785447 AW139327 BQ638591

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for JOSD1 About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b
SP1:			-		-
SP2:
SP3:					-
SP4:											-

ECgene alternative splicing isoforms for JOSD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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JOSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGATGCCCA

About this image

JOSD1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Bone (Muscoskeletal System)
Bone Marrow

JOSD1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

JOSD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.3094

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for JOSD1 gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Josd1⁵	Josephin domain containing 1	--		15 (37.85 cM) 79674250
chicken (Gallus gallus)	Aves	JOSD1¹	Josephin domain containing 1	84.98(n) 94.55(a)		418023 XM_416259.4 XP_416259.1
lizard (Anolis carolinensis)	Reptilia	JOSD1⁶	Josephin domain containing 1	91(a)	1 ↔ 1	5(24158080-24166393)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BG511968.1²	--	81.43(n)		BG511968.1
zebrafish (Danio rerio)	Actinopterygii	josd1¹	Josephin domain containing 1	71.31(n) 75.12(a)		767655 NM_001076595.2 NP_001070063.1
fruit fly (Drosophila melanogaster)	Insecta	CG3781⁶	--	37(a)	1 → many	X(6155202-6156152)
worm (Caenorhabditis elegans)	Secernentea	josd-1⁶	Protein JOSD-1 (josd-1) mRNA, complete cds	38(a)	1 → many	III(2836639-2838457) WBGene00022190
thale cress (Arabidopsis thaliana)	eudicotyledons	JOSL¹	JOSL	53.51(n) 44.22(a)		817514 NM_128518.1 NP_180525.1
rice (Oryza sativa)	Liliopsida	Os03g0265200¹	Os03g0265200	50.42(n) 35(a)		4332346 NM_001056181.1 NP_001049646.1

ENSEMBL Gene Tree for JOSD1 (if available)
TreeFam Gene Tree for JOSD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for JOSD1 gene

JOSD2²

2 SIMAP similar genes for JOSD1 using alignment to 6 protein entries: JOS1_HUMAN (see all proteins):

KIAA0063 JOSD2

JOSD1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for JOSD1
PGOHUM00000245282

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145363682^1,2		--	39081350(+)	`CAGTGC/TGGTAC`	1	--	ds500¹		0	--	--	--	--
rs149179550^1,2		--	39081471(+)	`CTATTC/TTGTCT`	1	--	ds500¹		0	--	--	--	--
rs144202966^1,2	C	--	39081621(+)	`GAGAC-/ATATATG`	1	--	ut3¹		0	--	--	--	--
rs143085344^1,2	C	--	39081633(+)	`GAGTTG/TTCCAT`	1	--	ut3¹		0	--	--	--	--
rs187396790^1,2		--	39081647(+)	`TAATAC/TTTGGT`	1	--	ut3¹		0	--	--	--	--
rs193118004^1,2		--	39081806(+)	`GCCCTG/TGGGCA`	1	--	ut3¹		0	--	--	--	--
rs115000958^1,2	C,F	--	39081842(+)	`ACCAGA/GATTGG`	1	--	ut3¹		1		WA	118
rs138585120^1,2		--	39082027(+)	`GTGGCC/TCCAAG`	1	--	ut3¹		0	--	--	--	--
rs5757243^1,2	H	--	39082043(+)	`GCTTGT/AGACAA`	1	--	ut3¹ ese³		4		NS EA	418
rs112395295^1,2	C,F	--	39082169(+)	`GACTGC/TGGCCA`	1	--	ut3¹		1		CSA	2

HapMap Linkage Disequilibrium report for JOSD1 (39081548 - 39097561 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for JOSD1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv915067	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing JOSD1

DNA2.0 Custom Variant and Variant Library Synthesis for JOSD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 615323 OMIM disorders: --

JOSD1 for disorders About GeneDecksing

Export disorders for JOSD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for JOSD1 gene, integrated from 10 sources (see all 25):
(articles sorted by number of sources associating them with JOSD1)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2, 3} Nomura N.... Tabata S. (DNA Res. 1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
Structural modeling of ataxin-3 reveals distant homology to adaptins. (PubMed id 12486728)^{1, 2} Albrecht M....Lengauer T. (Proteins 2003)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I.... Wright H. (Nature 1999)
JosD1, a membrane-targeted deubiquitinating enzyme, is activated by ubiquitination and regulates membrane dynamics, cell motility, and endocytosis. (PubMed id 23625928)² Seki T.... Paulson H.L. (J. Biol. Chem. 2013)
Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)¹ Loch C.M. and Strickler J.E. (Biochim. Biophys. Acta 2012)
Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)¹ Guo Z....Gao Y. (J. Proteome Res. 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9929	HGNC: 28953	AceView: KIAA0063	Ensembl:ENSG00000100221	euGenes: HUgn9929
ECgene: JOSD1	H-InvDB: JOSD1

(According to HUGE)
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HUGE: KIAA0063

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for JOSD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for JOSD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for JOSD1 gene:
Search GeneIP for patents involving JOSD1

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Josephin Domain Containing 1

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