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Aliases for JMY Gene

Aliases for JMY Gene

  • Junction Mediating And Regulatory Protein, P53 Cofactor 2 3
  • WAS Protein Homology Region 2 Domain Containing 1-Like 3 3
  • Junction-Mediating And -Regulatory Protein 3
  • Junction-Mediating And Regulatory Protein 3
  • WHDC1L3 3

External Ids for JMY Gene

Summaries for JMY Gene

GeneCards Summary for JMY Gene

JMY (Junction Mediating And Regulatory Protein, P53 Cofactor) is a Protein Coding gene. Among its related pathways are Direct p53 effectors. GO annotations related to this gene include actin binding and transcription coactivator activity. An important paralog of this gene is WHAMM.

UniProtKB/Swiss-Prot for JMY Gene

  • Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMY Gene

Genomics for JMY Gene

Genomic Location for JMY Gene

Start:
79,236,102 bp from pter
End:
79,327,215 bp from pter
Size:
91,114 bases
Orientation:
Plus strand

Genomic View for JMY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JMY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMY Gene

Regulatory Elements for JMY Gene

Proteins for JMY Gene

  • Protein details for JMY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9B5-JMY_HUMAN
    Recommended name:
    Junction-mediating and -regulatory protein
    Protein Accession:
    Q8N9B5
    Secondary Accessions:
    • A1L4P5
    • B5MDS2
    • B5MDT0

    Protein attributes for JMY Gene

    Size:
    988 amino acids
    Molecular mass:
    111445 Da
    Quaternary structure:
    • Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5 (By similarity).
    SequenceCaution:
    • Sequence=AAI30625.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04495.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW95834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for JMY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JMY Gene

Proteomics data for JMY Gene at MOPED

Post-translational modifications for JMY Gene

  • Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JMY Gene

Domains for JMY Gene

Protein Domains for JMY Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

JMY_HUMAN
Domain:
  • Contains 1 WH2 domain.:
    • Q8N9B5
Family:
  • Belongs to the JMY family.:
    • Q8N9B5
genes like me logo Genes that share domains with JMY: view

No data available for Gene Families for JMY Gene

Function for JMY Gene

Molecular function for JMY Gene

UniProtKB/Swiss-Prot Function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).
UniProtKB/Swiss-Prot Induction: By E2F.

Gene Ontology (GO) - Molecular Function for JMY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity ISS --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 10518217
genes like me logo Genes that share ontologies with JMY: view

miRNA for JMY Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for JMY Gene

Localization for JMY Gene

Subcellular locations from UniProtKB/Swiss-Prot for JMY Gene

Nucleus. Cytoplasm, cytoskeleton. Note=Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JMY Gene COMPARTMENTS Subcellular localization image for JMY gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for JMY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with JMY: view

Pathways for JMY Gene

SuperPathways for JMY Gene

Superpath Contained pathways
1 Direct p53 effectors
genes like me logo Genes that share pathways with JMY: view

Pathways by source for JMY Gene

1 BioSystems pathway for JMY Gene

Gene Ontology (GO) - Biological Process for JMY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
GO:0007050 cell cycle arrest ISS --
GO:0034314 Arp2/3 complex-mediated actin nucleation ISS --
GO:0043065 positive regulation of apoptotic process ISS --
genes like me logo Genes that share ontologies with JMY: view

Transcripts for JMY Gene

Unigene Clusters for JMY Gene

Junction mediating and regulatory protein, p53 cofactor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JMY Gene

No ASD Table

Relevant External Links for JMY Gene

GeneLoc Exon Structure for
JMY
ECgene alternative splicing isoforms for
JMY

Expression for JMY Gene

mRNA expression in normal human tissues for JMY Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JMY Gene

SOURCE GeneReport for Unigene cluster for JMY Gene Hs.482605

genes like me logo Genes that share expressions with JMY: view

Orthologs for JMY Gene

This gene was present in the common ancestor of chordates.

Orthologs for JMY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JMY 36
  • 99.56 (n)
  • 99.29 (a)
JMY 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JMY 36
  • 87.74 (n)
  • 88.45 (a)
JMY 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JMY 36
  • 89.61 (n)
  • 90.08 (a)
JMY 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jmy 36
  • 85.59 (n)
  • 87.5 (a)
Jmy 16
Jmy 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JMY 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JMY 37
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves JMY 36
  • 77.26 (n)
  • 80.14 (a)
JMY 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JMY 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jmy 36
  • 72.02 (n)
  • 75.68 (a)
zebrafish
(Danio rerio)
Actinopterygii jmy 36
  • 64.2 (n)
  • 65.84 (a)
jmy 37
  • 56 (a)
OneToOne
Species with no ortholog for JMY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JMY Gene

ENSEMBL:
Gene Tree for JMY (if available)
TreeFam:
Gene Tree for JMY (if available)

Paralogs for JMY Gene

Paralogs for JMY Gene

Selected SIMAP similar genes for JMY Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JMY: view

Variants for JMY Gene

Sequence variations from dbSNP and Humsavar for JMY Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs897744 -- 79,288,727(-) AACaa(A/C)caaaa intron-variant
rs975327 -- 79,294,983(-) GTATG(C/T)ATTCA intron-variant
rs1038992 -- 79,312,825(-) TAACA(A/T)GCTGA intron-variant
rs1316752 -- 79,235,569(-) TCTGA(A/G)GAAAG upstream-variant-2KB
rs1316753 -- 79,235,514(-) CCTAA(C/G)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for JMY Gene

Variant ID Type Subtype PubMed ID
nsv882216 CNV Loss 21882294
nsv4893 CNV Insertion 18451855
esv1481046 CNV Deletion 17803354
esv6669 CNV Gain 19470904

Relevant External Links for JMY Gene

HapMap Linkage Disequilibrium report
JMY

Disorders for JMY Gene

Relevant External Links for JMY

Genetic Association Database (GAD)
JMY
Human Genome Epidemiology (HuGE) Navigator
JMY
genes like me logo Genes that share disorders with JMY: view

No data available for UniProtKB/Swiss-Prot for JMY Gene

Publications for JMY Gene

  1. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard S.H. … Kristensen V.N. (Genes Chromosomes Cancer 2008) 3 49
  2. p53-cofactor JMY is a multifunctional actin nucleation factor. (PMID: 19287377) Zuchero J.B. … Mullins R.D. (Nat. Cell Biol. 2009) 3 4
  3. A novel cofactor for p300 that regulates the p53 response. (PMID: 10518217) Shikama N. … La Thangue N.B. (Mol. Cell 1999) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. (PMID: 15706352) Hershko T. … Ginsberg D. (Cell Death Differ. 2005) 3 4

Products for JMY Gene

Sources for JMY Gene

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