V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

JMY Gene

protein-coding   GIFtS: 54

GC05P078609
junction mediating and regulatory protein, p53 cofactor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ37870 1, 2
MGC163496 2
WHDC1L3 2
Descriptions
WAS protein homology region 2 domain containing 1-like 3 2
junction mediating and regulatory protein, p53 cofactor 2
junction-mediating and regulatory protein 2
External Ids
HGNC: 289161
Entrez Gene: 1337462
UniProtKB: Q8N9B53
Ensembl: ENSG000001524097
Search outside databases for aliases for JMY gene

Previous GC identifers: GC05U990090 GC05P078612 GC05P078657

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5
Function: Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases
p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress
response such as DNA damage (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the JMY gene  

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

JMY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P078609:     (about GC identifiers)

Start:
78,568,095 bp from pter
End:
78,658,794 bp from pter
Size:
90,700 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_006713.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5 (See protein sequence)
Recommended Name: Junction-mediating and -regulatory protein  
Size: 988 amino acids; 111445 Da
Subunit: Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts
with TTC5 (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=EAW95834.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L4P5
Alternative splicing: 2 isoforms:  Q8N9B5-1   Q8N9B5-2   

Post-translational modifications:

  • Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA
    damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with
    p300/EP300 and its function in p53/TP53 stress response (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_689618.3  

    ENSEMBL proteins: 
    ENSP00000379439 ENSP00000282259 ENSP00000379441 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (JMY)
    Human Recombinant Proteins from Abnova (JMY)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for JMY: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for JMY
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (JMY), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (JMY)
    Novus Biologicals Antibodies for JMY

    Assays for JMY: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR003124 WH2_actin_bd


       GeneDecks  JMY for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8N9B5

    ProtoNet protein and cluster: Q8N9B5

    1 Blocks protein family: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5
    Similarity: Contains 1 WH2 domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JMY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (JMY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152405

                  Applied Biosystems Silencer® siRNAs for JMY

                  Sigma-Aldrich siRNA for JMY  
                         Sigma-Aldrich shRNA Panels and shRNA for JMY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_152405
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_152405
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_152405 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_152405

    UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5
    Function: Cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases
    p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress
    response such as DNA damage (By similarity)
    Induction: By E2F

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713 transcription coactivator activity ISS--
    GO:0003779 actin binding IEA--
    GO:0005515 protein binding IPI10518217
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  JMY  (Your Favorite Gene powered by Ingenuity) 
     p53 Signaling

       GeneDecks  JMY for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  JMY 


    5/6 Interacting proteins for JMY (ENSP000002822593 Q8N9B51, 2) via UniProtKB, MINT, and/or STRING (see all 6 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371STRING (score=.901) EBI-866435, EBI-366083
    MDM2Q009871, 2STRING (score=.813) EBI-866435, EBI-389668 MINT-4052545 MINT-4052559 MINT-4052589 MINT-4052571 EBI-866435, EBI-389668 MINT-4052545 MINT-4052559 MINT-4052589 MINT-4052571
    MDM2Q009871, 2STRING (score=.813) EBI-866435, EBI-389668 MINT-4052545 MINT-4052559 MINT-4052589 MINT-4052571 EBI-866435, EBI-389668 MINT-4052545 MINT-4052559 MINT-4052589 MINT-4052571
    EP300ENSP000002632533STRING (score=.973)
    BAXENSP000002932883STRING (score=.915)
    About this table

    5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281 DNA repair IEA--
    GO:0006357 regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006917 induction of apoptosis ISS--
    GO:0006974 response to DNA damage stimulus IEA--
    GO:0007050 cell cycle arrest ISS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for JMY

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JMY)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (JMY)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_152405

                  Sigma-Aldrich siRNA for JMY  
                         Sigma-Aldrich shRNA Panels and shRNA for JMY  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_152405  

    REFSEQ mRNAs for JMY gene: 

    NM_152405.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_152405  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_152405
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_152405
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_152405 

    Additional cDNA sequence: 

    AK092475.1 AK095189.1 BC130624.1 BX648048.1 BX648731.1 

    7 DOTS entries:

    DT.405373  DT.440176  DT.95360678  DT.95143615  DT.120889481  DT.75122447  DT.120889487 

    24/92 AceView cDNA sequences (see all 92 ):

    AA578673 BM693456 BQ003021 AA255887 AA255893 AI697448 BQ082942 BM668734 
    AI865843 CD365157 AA443183 BQ083758 BE673561 BQ083541 CB137321 BF447037 
    AA608739 CA418445 BQ007076 BF724912 AA810754 AI922383 AI391663 AK095189 

    highest scoring ESTs for JMY:

    AA255887 AI814405 AK095189 AL708168 BX648731 AA255893 AA291280 AA443183 AA506395 AA810754 

    Unigene Cluster for JMY:

    Junction mediating and regulatory protein, p53 cofactor
    Hs.482605  [show with all ESTs]
    Unigene Representative Sequence: NM_152405


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000396135  ENST00000282259  ENST00000396137  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    JMY expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for JMY

    1 / 2 / 3

    8 probe-sets matching JMY gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    51247_at2, 3 U95-B 1 1.00 1.00 0.74 1.41 AI264314 0.60 1.00 0.82 1

    72316_at2, 3 U95-E 1 1.00 1.00 0.83 0.79 AI814405 0.80 1.00 0.91 1

    42878_at2, 3 U95-B 1 1.00 1.00 0.75 0.59 AA255887 0.80 1.00 0.91 1
    76664_at2, 3 U95-D 2 1.00 0.97 0.91 1.25 H95404 0.60 1.00 0.82 1

    226352_at2, 3 U133-B 1 1.00 1.00 -- -- BF447037 0.40 1.00 0.76 1

    241985_at2, 3 U133-B 1 1.00 1.00 -- -- AI814405 0.80 1.00 0.91 1

    226352_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    241985_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  JMY for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CAATGTAACA

    SOURCE GeneReport for Unigene cluster: Hs.482605
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for JMY gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6103231   -- similar to junction-mediating and regulatory protein 90.73(n)
    92.56(a)
    610323  XM_847801.1  XP_852894.1 
    chimpanzee
    (Pan troglodytes)
    LOC4617841   -- junction-mediating and regulatory protein 99.67(n)
    99.44(a)
    461784  XM_517685.2  XP_517685.2 
    cow
    (Bos taurus)
    LOC5284981   -- similar to Junction-mediating and regulatory protein 87.68(n)
    89.6(a)
    528498  XM_606924.3  XP_606924.3 
    mouse
    (Mus musculus)
    Jmy1, 5 135
    junction-mediating and regulatory protein1, 5 87.93(n)1
    90.85(a)1
    577481  NM_021310.21  NP_067285.21 
     AA4148775  AA5910595  (see all 18)
    About this table        Species with no ortholog for JMY

    ENSEMBL Gene Tree for JMY
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for JMY gene
    WHAMM2  WHAMML12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/437 NCBI SNPs in JMY are shown (see all 437 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 104)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs13167531,2
    A,C,F,H,O78567093(-) CCTAAG/CAGCAT 1 -- ng5115Minor allele frequency- C:0.41NA PA NS MN EU EA WA 1144
    rs10623261,2
    A,C,F,H78653290(+) AAAGTG/TCATTG 1 -- ut31 ese312Minor allele frequency- T:0.33MN NA EU EA WA 1162
    rs37338861,2
    A,C,F,H78657424(-) CCAAAC/ACCTTT 1 -- ut3114Minor allele frequency- A:0.46EA NA EU WA 2460
    rs77025231,2
    A,C,F,H78656597(+) CATAGC/TAGACA 1 -- ut317Minor allele frequency- T:0.36NA EU EA WA 562
    rs119552331,2
    C,F,H78654429(+) GTGGAG/TGGAGT 1 -- ut3111Minor allele frequency- T:0.03NA EU EA WA 978
    rs77059301,2
    A,F,H78654457(+) AAAATC/TACTTT 1 -- ut314Minor allele frequency- T:0.03EU EA WA 416
    rs104623631,2
    C,F,H78655155(+) TTTACG/ATACCC 1 -- ut314Minor allele frequency- A:0.04EU EA WA 420
    rs121094751,2
    C,F,H78632336(+) ATCTGC/TGTACT 1 A/V mis1 ese39Minor allele frequency- T:0.02EU EA WA NA 896
    rs37338851,2
    C,F,H78657453(-) TCGCCG/AAATCT 1 -- ut3112Minor allele frequency- A:0.13EA NA EU WA 2460
    rs168766571,2
    C,F,H78645930(+) GGATCA/GTTGTG 1 H/R mis1 ese311Minor allele frequency- G:0.12NA EU EA WA 982
    About this table

    HapMap Linkage Disequilibrium images for JMY (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604279

    Human Genome Epidemiology Navigator: JMY (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for JMY gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 133746 HGNC: 28916 AceView: JMY Ensembl:ENSG00000152409 euGenes: HUgn133746
    ECgene: JMY H-InvDB: JMY
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for JMY:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for JMY-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for JMY Antibodies for JMY
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for JMY Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (JMY)
     Antibodies (JMY)
     Chimera RNAi (JMY)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (JMY)
     Antibodies (JMY)
     Search OriGene for JMY
     Search Tocris compounds for JMY




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for JMY

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    JMY Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com