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JMY Gene

protein-coding   GIFtS: 53
GCID: GC05P078531

Junction Mediating And Regulatory Protein, P53 Cofactor

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Junction Mediating And Regulatory Protein, P53 Cofactor1 2
WHDC1L32
Junction-Mediating And -Regulatory Protein2
Junction-Mediating And Regulatory Protein2
WAS Protein Homology Region 2 Domain Containing 1-Like 32

External Ids:    HGNC: 289161   Entrez Gene: 1337462   Ensembl: ENSG000001524097   OMIM: 6042795   UniProtKB: Q8N9B53   

Export aliases for JMY gene to outside databases

Previous GC identifers: GC05U990090 GC05P078612 GC05P078657 GC05P078609 GC05P073740


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JMY Gene:
JMY (junction mediating and regulatory protein, p53 cofactor) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and actin binding. An important paralog of this gene is WHAMM.

UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5
Function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on
conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300.
Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress
response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched
actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin
polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by
controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new
mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin
activator activities are regulated via its subcellular location (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JMY gene promoter:
         HOXA9B   Sox5   FOXF2   AML1a   C/EBPalpha   Evi-1   CHOP-10   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): JMY promoter sequence
   Search Chromatin IP Primers for JMY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JMY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.1   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.1

JMY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMY gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P078531:  view genomic region     (about GC identifiers)

Start:
78,531,925 bp from pter      End:
78,623,038 bp from pter
Size:
91,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5 (See protein sequence)
Recommended Name: Junction-mediating and -regulatory protein  
Size: 988 amino acids; 111445 Da
Subunit: Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5 (By
similarity)
Sequence caution: Sequence=AAI30625.1; Type=Erroneous initiation; Sequence=BAC04495.1; Type=Erroneous initiation;
Sequence=EAW95834.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L4P5 B5MDS2 B5MDT0
Alternative splicing: 2 isoforms:  Q8N9B5-1   Q8N9B5-2   

Explore the universe of human proteins at neXtProt for JMY: NX_Q8N9B5

Explore proteomics data for JMY at MOPED

Post-translational modifications: 

  • Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the
    interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its
    function in p53/TP53 stress response (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JMY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689618.4  
    ENSEMBL proteins: 
     ENSP00000379441  

    JMY Human Recombinant Protein Products:

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    JMY Assay Products:

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    Search eBioscience for ELISAs for JMY 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003124 WH2_dom

    Graphical View of Domain Structure for InterPro Entry Q8N9B5

    ProtoNet protein and cluster: Q8N9B5

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: JMY_HUMAN, Q8N9B5
    Similarity: Belongs to the JMY family
    Similarity: Contains 1 WH2 domain


    Find genes that share domains with JMY           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JMY_HUMAN, Q8N9B5
    Function: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on
    conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300.
    Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress
    response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched
    actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin
    polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by
    controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new
    mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin
    activator activities are regulated via its subcellular location (By similarity)
    Induction: By E2F

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity ISS--
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI10518217
         
    Find genes that share ontologies with JMY           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JMY
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JMY
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    miRNA
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    miRTarBase miRNAs that target JMY:
    hsa-mir-130b-5p (MIRT038309), hsa-mir-335-5p (MIRT016890), hsa-mir-21-5p (MIRT005323)

    Block miRNA regulation of human, mouse, rat JMY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JMY (see all 122):
    hsa-miR-3130-5p hsa-miR-642a hsa-miR-607 hsa-miR-193a-3p hsa-miR-128 hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidJMY 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat JMY

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    GenScript: all cDNA clones in your preferred vector: JMY (NM_152405)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMY

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JMY_HUMAN, Q8N9B5: Nucleus (By similarity). Cytoplasm, cytoskeleton. Note=Localizes to the nucleus in most cell
    types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and
    reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin
    filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it
    moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into
    highly motile neutrophil-like cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0031252cell leading edge IDA19287377

    Find genes that share ontologies with JMY           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JMY About    
    See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for JMY
        Direct p53 effectors



        Pathway & Disease-focused RT2 Profiler PCR Array including JMY: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JMY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for JMY (Q8N9B51, 2, 3 ENSP000003794414) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009871, 2, 3, ENSP000004172814EBI-866435,EBI-389668 MINT-4052545 MINT-4052559 MINT-4052589 MINT-4052571 I2D: score=2 STRING: ENSP00000417281
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    BAXENSP000002932884STRING: ENSP00000293288
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--
    GO:0007050cell cycle arrest ISS--
    GO:0034314Arp2/3 complex-mediated actin nucleation ISS--
    GO:0043065positive regulation of apoptotic process ISS--

    Find genes that share ontologies with JMY           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JMY



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JMY gene: 
    NM_152405.4  

    Unigene Cluster for JMY:

    Junction mediating and regulatory protein, p53 cofactor
    Hs.482605  [show with all ESTs]
    Unigene Representative Sequence: NM_152405
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396137(uc003kfx.4 uc003kfw.1) ENST00000412001
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate JMY (see all 122):
    hsa-miR-3130-5p hsa-miR-642a hsa-miR-607 hsa-miR-193a-3p hsa-miR-128 hsa-miR-374a hsa-miR-759 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidJMY 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: JMY (NM_152405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JMY
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMY
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for JMY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JMY
      QuantiTect SYBR Green Assays in human, mouse, rat JMY
      QuantiFast Probe-based Assays in human, mouse, rat JMY

    Additional mRNA sequence: 

    AK092475.1 AK095189.1 BC130624.1 BX648048.1 BX648731.1 

    7 DOTS entries:

    DT.405373  DT.440176  DT.95360678  DT.120889481  DT.95143615  DT.75122447  DT.120889487 

    Selected AceView cDNA sequences (see all 92):

    BQ082942 AI697448 BE673561 CB137321 AA443183 AI391663 BQ003021 AA810754 
    BM668734 BQ007076 AA578673 AI922383 BQ083541 AA255893 AA255887 BQ083758 
    AI865843 AA608739 BF724912 CD365157 BF447037 BM693456 CA418445 BI333191 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JMY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAATGTAACA
    JMY Expression
    About this image

    JMY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JMY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482605
        Pathway & Disease-focused RT2 Profiler PCR Array including JMY: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for JMY gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jmy1 , 5 junction-mediating and regulatory protein1, 5 85.59(n)1
    87.5(a)1
      13 (47.85 cM)5
    577481  NM_021310.31  NP_067285.21 
     934300975 
    chicken
    (Gallus gallus)
    Aves JMY1 junction mediating and regulatory protein, p53 cofactor 77.26(n)
    80.14(a)
      427182  XM_003642911.2  XP_003642959.1 
    lizard
    (Anolis carolinensis)
    Reptilia JMY6
    junction mediating and regulatory protein, p53 cof...
    71(a)
    1 ↔ 1
    2(12905790-12937861)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia jmy1 junction mediating and regulatory protein, p53 cofactor 72.02(n)
    75.68(a)
      100127594  NM_001112955.1  NP_001106426.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jmy1 junction mediating and regulatory protein, p53 cofactor 64.2(n)
    65.84(a)
      406556  NM_213272.1  NP_998437.1 


    ENSEMBL Gene Tree for JMY (if available)
    TreeFam Gene Tree for JMY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JMY gene
    WHAMM2  
    2 SIMAP similar genes for JMY using alignment to 1 protein entry:     JMY_HUMAN:
    WHAMMP3    WHAMM

    Find genes that share paralogs with JMY           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JMY (see all 1932)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779231931,2
    C,F--78529966(+) ATGGGA/GTCATG 1 -- us2k12Minor allele frequency- G:0.05NA EA 240
    rs1135973941,2
    C--78530113(+) AGTCTC/TTGTCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1880226731,2
    --78530134(+) AGTGCC/GGTGGC 1 -- us2k10--------
    rs1921939811,2
    C--78530171(+) CCTCCA/CGGGTT 1 -- us2k10--------
    rs1408433471,2
    --78530212(+) TAGCTA/GGGATT 1 -- us2k10--------
    rs1119782691,2
    C,F--78530225(+) AGGCAG/CGTGCC 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1456363121,2
    --78530226(+) GGCACA/GTGCCA 1 -- us2k10--------
    rs1827351181,2
    --78530266(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1879083441,2
    --78530418(+) TTTGCC/GTTTCA 1 -- us2k10--------
    rs1166013041,2
    C,F--78530428(+) AGAACG/CTGTCT 1 -- us2k11Minor allele frequency- C:0.04WA 118

    HapMap Linkage Disequilibrium report for JMY (78531925 - 78623038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for JMY:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1481046CNV Deletion17803354
    nsv4893CNV Insertion18451855
    nsv882216CNV Loss21882294
    esv6669CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604279    OMIM disorders: --


    Find genes that share disorders with JMY           About GenesLikeMe

    Genetic Association Database (GAD): JMY
    Human Genome Epidemiology (HuGE) Navigator: JMY (1 document)

    Export disorders for JMY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JMY gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with JMY)
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    1. p53-cofactor JMY is a multifunctional actin nucleation factor. (PubMed id 19287377)1, 2 Zuchero J.B.... Mullins R.D. (Nat. Cell Biol. 2009)
    2. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PubMed id 18398821)1, 4 Nordgard S.H....Kristensen V.N. (amp 2008)
    3. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. (PubMed id 15706352)1, 2 Hershko T.... Ginsberg D. (Cell Death Differ. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A novel cofactor for p300 that regulates the p53 response. (PubMed id 10518217)1, 3 Shikama N....La Thangue N.B. (Mol. Cell 1999)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. JMY polymorphism is related to severity of ankylosing spondylitis in Chinese Han patients. (PubMed id 23758122)1 Chai W....Wang Y. (Genet Test Mol Biomarkers 2013)
    8. Actin binding to WH2 domains regulates nuclear import of the multifunctional actin regulator JMY. (PubMed id 22262458)1 Zuchero J.B....Mullins R.D. (Mol. Biol. Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1I+. (PubMed id 21625218)1 Coutts A.S....La Thangue N.B. (Oncogene 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 133746 HGNC: 28916 AceView: JMY Ensembl:ENSG00000152409 euGenes: HUgn133746
    ECgene: JMY H-InvDB: JMY

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JMY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JMY gene:
    Search GeneIP for patents involving JMY

    GeneCards and IP:
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