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Aliases for JMJD8 Gene

Aliases for JMJD8 Gene

  • Jumonji Domain Containing 8 2 3 5
  • Jumonji Domain-Containing Protein 8 3 4
  • C16orf20 3 4
  • Chromosome 16 Open Reading Frame 20 2
  • PP14397 3

External Ids for JMJD8 Gene

Previous HGNC Symbols for JMJD8 Gene

  • C16orf20

Previous GeneCards Identifiers for JMJD8 Gene

  • GC16M000673
  • GC16M000676
  • GC16M000731
  • GC16M000653

Summaries for JMJD8 Gene

GeneCards Summary for JMJD8 Gene

JMJD8 (Jumonji Domain Containing 8) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD8 Gene

Genomics for JMJD8 Gene

Regulatory Elements for JMJD8 Gene

Promoters for JMJD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JMJD8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the JMJD8 gene promoter:

Genomic Location for JMJD8 Gene

681,667 bp from pter
684,528 bp from pter
2,862 bases
Minus strand

Genomic View for JMJD8 Gene

Genes around JMJD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD8 Gene

Proteins for JMJD8 Gene

  • Protein details for JMJD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    JmjC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • B2RNS7
    • D3DU58
    • Q4PKE3
    • Q4VBY1
    • Q6GMW5
    • Q71RB8

    Protein attributes for JMJD8 Gene

    334 amino acids
    Molecular mass:
    36870 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI37101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI37102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15256.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JMJD8 Gene


neXtProt entry for JMJD8 Gene

Proteomics data for JMJD8 Gene at MOPED

Post-translational modifications for JMJD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for JMJD8 Gene

Domains & Families for JMJD8 Gene

Protein Domains for JMJD8 Gene


Suggested Antigen Peptide Sequences for JMJD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 JmjC domain.
  • Contains 1 JmjC domain.
genes like me logo Genes that share domains with JMJD8: view

No data available for Gene Families for JMJD8 Gene

Function for JMJD8 Gene

Phenotypes for JMJD8 Gene

genes like me logo Genes that share phenotypes with JMJD8: view

Animal Model Products

CRISPR Products

miRNA for JMJD8 Gene

miRTarBase miRNAs that target JMJD8

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JMJD8 Gene

Localization for JMJD8 Gene

Subcellular locations from

Jensen Localization Image for JMJD8 Gene COMPARTMENTS Subcellular localization image for JMJD8 gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for JMJD8 Gene

Pathways & Interactions for JMJD8 Gene

SuperPathways for JMJD8 Gene

No Data Available

Interacting Proteins for JMJD8 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000399475 for JMJD8 Gene via STRING

Gene Ontology (GO) - Biological Process for JMJD8 Gene


No data available for Pathways by source and SIGNOR curated interactions for JMJD8 Gene

Drugs & Compounds for JMJD8 Gene

No Compound Related Data Available

Transcripts for JMJD8 Gene

Unigene Clusters for JMJD8 Gene

Jumonji domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD8 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - - -

Relevant External Links for JMJD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JMJD8 Gene

mRNA expression in normal human tissues for JMJD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JMJD8 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JMJD8 Gene

SOURCE GeneReport for Unigene cluster for JMJD8 Gene Hs.533771

genes like me logo Genes that share expression patterns with JMJD8: view

Protein tissue co-expression partners for JMJD8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JMJD8 Gene

Orthologs for JMJD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for JMJD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia JMJD8 35
  • 84.58 (n)
  • 85.45 (a)
JMJD8 36
  • 82 (a)
(Mus musculus)
Mammalia Jmjd8 35
  • 81.82 (n)
  • 86.36 (a)
Jmjd8 16
Jmjd8 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Jmjd8 35
  • 80.85 (n)
  • 86.78 (a)
(Bos Taurus)
Mammalia JMJD8 36
  • 79 (a)
(Monodelphis domestica)
Mammalia JMJD8 36
  • 81 (a)
(Gallus gallus)
Aves JMJD8 35
  • 77.27 (n)
  • 76.15 (a)
gga-mir-6643 36
  • 71 (a)
(Anolis carolinensis)
Reptilia JMJD8 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498157 35
  • 68.18 (n)
  • 74.79 (a)
Str.15601 35
(Danio rerio)
Actinopterygii LOC100330060 35
  • 64.84 (n)
  • 67.51 (a)
CABZ01015475.1 36
  • 62 (a)
(Caenorhabditis elegans)
Secernentea C27F2.9 35
  • 50.98 (n)
  • 49.16 (a)
C27F2.9 36
  • 45 (a)
Species with no ortholog for JMJD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JMJD8 Gene

Gene Tree for JMJD8 (if available)
Gene Tree for JMJD8 (if available)

Paralogs for JMJD8 Gene

No data available for Paralogs for JMJD8 Gene

Variants for JMJD8 Gene

Sequence variations from dbSNP and Humsavar for JMJD8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11863733 -- 683,515(+) GCCGC(C/G/T)TAGGG intron-variant
rs12920939 -- 683,947(+) GACCG(A/C)CAGCC intron-variant
rs45540637 -- 683,292(+) AGCCT(C/T)AGTCC intron-variant
rs72773413 -- 683,424(+) GTCCC(C/G)GAAGA reference, missense
rs74002825 -- 683,441(+) GGGTG(G/T)CTGCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for JMJD8 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
dgv2487n71 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv904785 CNV Gain+Loss 21882294
dgv2490n71 CNV Loss 21882294
nsv9321 CNV Gain+Loss 18304495
nsv457310 CNV Loss 19166990
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv904799 CNV Loss 21882294
nsv827480 CNV Gain 20364138
dgv2493n71 CNV Loss 21882294
dgv2494n71 CNV Loss 21882294
nsv904803 CNV Loss 21882294
nsv482181 CNV Gain 20164927
nsv482182 CNV Gain 20164927
nsv457311 CNV Loss 19166990

Variation tolerance for JMJD8 Gene

Gene Damage Index Score: 3.52; 55.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JMJD8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD8 Gene

Disorders for JMJD8 Gene

Relevant External Links for JMJD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JMJD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD8 Gene

Publications for JMJD8 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3

Products for JMJD8 Gene

Sources for JMJD8 Gene

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