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Aliases for JMJD8 Gene

Aliases for JMJD8 Gene

  • Jumonji Domain Containing 8 2 3 5
  • Jumonji Domain-Containing Protein 8 3 4
  • C16orf20 3 4
  • Chromosome 16 Open Reading Frame 20 2
  • JmjC Domain-Containing Protein 8 3
  • PP14397 3

External Ids for JMJD8 Gene

Previous HGNC Symbols for JMJD8 Gene

  • C16orf20

Previous GeneCards Identifiers for JMJD8 Gene

  • GC16M000673
  • GC16M000676
  • GC16M000731
  • GC16M000653

Summaries for JMJD8 Gene

GeneCards Summary for JMJD8 Gene

JMJD8 (Jumonji Domain Containing 8) is a Protein Coding gene.

Additional gene information for JMJD8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD8 Gene

Genomics for JMJD8 Gene

GeneHancer (GH) Regulatory Elements for JMJD8 Gene

Promoters and enhancers for JMJD8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000682 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 561.4 +0.3 309 2.5 HDGF PKNOX1 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 JMJD8 PIR39109 PIR58864 CRAMP1 WDR90 LUC7L TELO2 UBE2I ENSG00000260051 ENSG00000268836
GH16I000686 Enhancer 0.6 ENCODE 550.8 -1.6 -1638 0.1 CTCF NFIA NFIB MAX ZNF76 ZNF2 RAD21 BCL11B HIC1 NFIC JMJD8 PIR39109 ENSG00000261659 WDR24
GH16I001308 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 121.3 -626.2 -626226 5.2 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 UBE2I LOC102723815 WDR90 CRAMP1 TELO2 ENSG00000261505 E4F1 TSC2 ENSG00000260051 IFT140
GH16I000981 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 64.2 -296.9 -296873 1.6 ZNF493 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF213 ZNF416 KLF7 ZNF548 ENSG00000260807 LMF1 SOX8 GC16M000982 GC16P001002 GC16M000980 WDR90 CRAMP1 ENSG00000261505 UBE2I
GH16I001271 Enhancer 1.1 ENCODE 91.4 -587.3 -587298 1.6 PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZNF213 ZNF302 ZNF416 KLF13 SP3 CRAMP1 WDR90 IFT140 TELO2 ENSG00000260646 TSC2 ENSG00000261505 E4F1 WDR24 ENSG00000260051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around JMJD8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the JMJD8 gene promoter:

Genomic Locations for JMJD8 Gene

Genomic Locations for JMJD8 Gene
chr16:681,667-684,528
(GRCh38/hg38)
Size:
2,862 bases
Orientation:
Minus strand
chr16:731,667-734,529
(GRCh37/hg19)

Genomic View for JMJD8 Gene

Genes around JMJD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD8 Gene

Proteins for JMJD8 Gene

  • Protein details for JMJD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96S16-JMJD8_HUMAN
    Recommended name:
    JmjC domain-containing protein 8
    Protein Accession:
    Q96S16
    Secondary Accessions:
    • B2RNS7
    • D3DU58
    • Q4PKE3
    • Q4VBY1
    • Q6GMW5
    • Q71RB8

    Protein attributes for JMJD8 Gene

    Size:
    334 amino acids
    Molecular mass:
    36870 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI37101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI37102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15256.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JMJD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JMJD8 Gene

Post-translational modifications for JMJD8 Gene

No Post-translational modifications

Antibody Products

  • Abcam antibodies for JMJD8
  • Santa Cruz Biotechnology (SCBT) Antibodies for JMJD8

No data available for DME Specific Peptides for JMJD8 Gene

Domains & Families for JMJD8 Gene

Gene Families for JMJD8 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for JMJD8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JMJD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JMJD8: view

No data available for UniProtKB/Swiss-Prot for JMJD8 Gene

Function for JMJD8 Gene

Phenotypes From GWAS Catalog for JMJD8 Gene

Phenotypes for JMJD8 Gene

genes like me logo Genes that share phenotypes with JMJD8: view

Animal Models for JMJD8 Gene

MGI Knock Outs for JMJD8:

Animal Model Products

miRNA for JMJD8 Gene

miRTarBase miRNAs that target JMJD8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JMJD8 Gene

Localization for JMJD8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JMJD8 gene
Compartment Confidence
extracellular 5
mitochondrion 3
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for JMJD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA 23376485
genes like me logo Genes that share ontologies with JMJD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for JMJD8 Gene

Pathways & Interactions for JMJD8 Gene

SuperPathways for JMJD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JMJD8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JMJD8 Gene

Drugs & Compounds for JMJD8 Gene

No Compound Related Data Available

Transcripts for JMJD8 Gene

Unigene Clusters for JMJD8 Gene

Jumonji domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD8 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - - -
SP9:
SP10:

Relevant External Links for JMJD8 Gene

GeneLoc Exon Structure for
JMJD8
ECgene alternative splicing isoforms for
JMJD8

Expression for JMJD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JMJD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JMJD8 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JMJD8 Gene



Protein tissue co-expression partners for JMJD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JMJD8 Gene:

JMJD8

SOURCE GeneReport for Unigene cluster for JMJD8 Gene:

Hs.533771

Evidence on tissue expression from TISSUES for JMJD8 Gene

  • Kidney(4.3)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with JMJD8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD8 Gene

Orthologs for JMJD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for JMJD8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia JMJD8 33 34
  • 84.58 (n)
mouse
(Mus musculus)
Mammalia Jmjd8 33 16 34
  • 81.82 (n)
oppossum
(Monodelphis domestica)
Mammalia JMJD8 34
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jmjd8 33
  • 80.85 (n)
cow
(Bos Taurus)
Mammalia JMJD8 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves JMJD8 33
  • 77.27 (n)
gga-mir-6643 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JMJD8 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498157 33
  • 68.18 (n)
Str.15601 33
zebrafish
(Danio rerio)
Actinopterygii LOC100330060 33
  • 64.84 (n)
CABZ01015475.1 34
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27F2.9 33 34
  • 50.98 (n)
Species where no ortholog for JMJD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JMJD8 Gene

ENSEMBL:
Gene Tree for JMJD8 (if available)
TreeFam:
Gene Tree for JMJD8 (if available)

Paralogs for JMJD8 Gene

No data available for Paralogs for JMJD8 Gene

Variants for JMJD8 Gene

Sequence variations from dbSNP and Humsavar for JMJD8 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs587777340 pathogenic, Spinocerebellar ataxia, autosomal recessive 16 681,572(-) C/T downstream_transcript_variant
rs587777341 pathogenic, Spinocerebellar ataxia, autosomal recessive 16 681,468(-) A/T downstream_transcript_variant
rs587777342 pathogenic, Spinocerebellar ataxia, autosomal recessive 16 681,520(-) G/A/T downstream_transcript_variant
rs587777343 pathogenic, Spinocerebellar ataxia, autosomal recessive 16 682,232(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs587777344 pathogenic, Spinocerebellar ataxia, autosomal recessive 16 681,446(-) C/G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for JMJD8 Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457310 CNV loss 19166990
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv482181 CNV gain 20164927
nsv482182 CNV gain 20164927
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv571016 CNV loss 21841781
nsv827480 CNV gain 20364138
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for JMJD8 Gene

Gene Damage Index Score: 3.52; 55.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for JMJD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JMJD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD8 Gene

Disorders for JMJD8 Gene

Additional Disease Information for JMJD8

No disorders were found for JMJD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD8 Gene

Publications for JMJD8 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. (PMID: 27199445) Boeckel JN … Dimmeler S (Arteriosclerosis, thrombosis, and vascular biology 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58

Products for JMJD8 Gene

Sources for JMJD8 Gene

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