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JMJD8 Gene

protein-coding   GIFtS: 42
GCID: GC16M000731

Jumonji Domain Containing 8

(Previous name: chromosome 16 open reading frame 20)
(Previous symbol: C16orf20)
  Search for JMJD8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jumonji Domain Containing 81 2
C16orf201 2 3
Jumonji Domain-Containing Protein 82 3
Chromosome 16 Open Reading Frame 201
JmjC Domain-Containing Protein 82

External Ids:    HGNC: 141481   Entrez Gene: 3391232   Ensembl: ENSG000001619997   UniProtKB: Q96S163   

Export aliases for JMJD8 gene to outside databases

Previous GC identifers: GC16M000673 GC16M000676 GC16M000653


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JMJD8 Gene:
JMJD8 (jumonji domain containing 8) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JMJD8 gene promoter:
         Sp1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJMJD8 promoter sequence
   Search Chromatin IP Primers for JMJD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JMJD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

JMJD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000731:  view genomic region     (about GC identifiers)

Start:
731,667 bp from pter      End:
734,529 bp from pter
Size:
2,863 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JMJD8_HUMAN, Q96S16 (See protein sequence)
Recommended Name: JmjC domain-containing protein 8  
Size: 334 amino acids; 36870 Da
Caution: It is uncertain whether Met-1 or Met-50 is the initiator
Sequence caution: Sequence=AAI37101.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI37102.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ15256.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RNS7 D3DU58 Q4PKE3 Q4VBY1 Q6GMW5 Q71RB8
Alternative splicing: 2 isoforms:  Q96S16-1   Q96S16-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JMJD8: NX_Q96S16

Explore proteomics data for JMJD8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JMJD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001005920.2  
    ENSEMBL proteins: 
     ENSP00000399475   ENSP00000477481   ENSP00000454358   ENSP00000458106   ENSP00000454700  
     ENSP00000293882   ENSP00000394147  

    JMJD8 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for JMJD8

     
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    JMJD8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of JMJD8
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    Novus Biologicals JMJD8 Antibodies
    Abcam antibodies for JMJD8 (B2RNS7, Q96S16)
    Cloud-Clone Corp. Antibodies for JMJD8
    ThermoFisher Antibodies for JMJD8
    LSBio Antibodies in human, mouse, rat for JMJD8

    JMJD8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for JMJD8
    Cloud-Clone Corp. CLIAs for JMJD8
    Search eBioscience for ELISAs for JMJD8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q96S16

    ProtoNet protein and cluster: Q96S16

    UniProtKB/Swiss-Prot: JMJD8_HUMAN, Q96S16
    Similarity: Contains 1 JmjC domain


    Find genes that share domains with JMJD8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with JMJD8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JMJD8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JMJD8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JMJD8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JMJD8

    miRNA
    Products:
        
    miRTarBase miRNAs that target JMJD8:
    hsa-mir-93-3p (MIRT038844)

    Block miRNA regulation of human, mouse, rat JMJD8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate JMJD8:
    hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidJMJD8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for JMJD8
    Predesigned siRNA for gene silencing in human, mouse, rat JMJD8

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: JMJD8 (NM_001005920)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JMJD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JMJD8
    Interactions:

        Search GeneGlobe Interaction Network for JMJD8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JMJD8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JMJD8 gene: 
    NM_001005920.2  

    Unigene Cluster for JMJD8:

    Jumonji domain containing 8
    Hs.533771  [show with all ESTs]
    Unigene Representative Sequence: NM_001005920
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412368(uc002ciw.1 uc002ciy.1) ENST00000567120 ENST00000565302
    ENST00000568689 ENST00000609261 ENST00000568313 ENST00000569441 ENST00000562824
    ENST00000563088 ENST00000564436 ENST00000570037 ENST00000562111 ENST00000565258
    ENST00000569396 ENST00000566199 ENST00000567901 ENST00000293882 ENST00000454700

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat JMJD8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate JMJD8:
    hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidJMJD8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for JMJD8
    Predesigned siRNA for gene silencing in human, mouse, rat JMJD8
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    OriGene clones in human, mouse for JMJD8 (see all 6)
    OriGene ORF clones in mouse, rat for JMJD8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JMJD8 (NM_001005920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JMJD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for JMJD8
    OriGene qSTAR qPCR primer pairs in human, mouse for JMJD8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JMJD8
      QuantiTect SYBR Green Assays in human, mouse, rat JMJD8
      QuantiFast Probe-based Assays in human, mouse, rat JMJD8

    Additional mRNA sequence: 

    AF370420.1 BC073785.1 BC094850.1 BC137100.1 BC137101.1 BC150144.1 DQ074695.1 

    17 DOTS entries:

    DT.100637940  DT.219419  DT.91788875  DT.95084511  DT.120670723  DT.100654787  DT.40264699  DT.92389737 
    DT.95084530  DT.100703078  DT.92452997  DT.447259  DT.100723261  DT.95084584  DT.95084510  DT.95205691 
    DT.99955565 

    Selected AceView cDNA sequences (see all 590):

    BE790834 CD251875 BM554498 BG284477 CR625506 CR613585 CK819928 CR608736 
    AW959861 AI272162 AI694759 BQ671851 BG574226 AA364919 AI399661 AW170557 
    AW163613 BI767435 AI360163 AI218039 BM142155 BM704595 AI869896 BM127809 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for JMJD8 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -           -                 -                                                         
    SP2:        -     -     -     -           -                 -                                                         
    SP3:                          -                             -                                                         
    SP4:                          -           -                                                                           
    SP5:                          -                             -                                                         


    ECgene alternative splicing isoforms for JMJD8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JMJD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTGGGGG
    JMJD8 Expression
    About this image


    JMJD8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    JMJD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JMJD8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533771
        Custom PCR Arrays for JMJD8
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    QuantiFast Probe-based Assays in human, mouse, rat JMJD8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JMJD8 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jmjd81 , 5 jumonji domain containing 81, 5 81.82(n)1
    86.36(a)1
      17 (12.92 cM)5
    721061  NM_028101.41  NP_082377.21 
     258288675 
    chicken
    (Gallus gallus)
    Aves JMJD81 jumonji domain containing 8 77.27(n)
    76.15(a)
      426917  XM_424526.4  XP_424526.3 
    lizard
    (Anolis carolinensis)
    Reptilia JMJD86
    jumonji domain containing 8
    78(a)
    1 ↔ 1
    GL344104.1(2275-21376)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156012 Transcribed sequence with weak similarity to protein more 76.82(n)    BX739808.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300601 jmjC domain-containing protein 8-like 64.84(n)
    67.51(a)
      100330060  XM_003197992.2  XP_003198040.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C27F2.91 C27F2.9 50.98(n)
    49.16(a)
      175673  NM_065652.5  NP_498053.2 


    ENSEMBL Gene Tree for JMJD8 (if available)
    TreeFam Gene Tree for JMJD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JMJD8 (see all 52)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455406371,2
    C--733292(+) AGCCTC/TAGTCC 1 -- int10--------
    rs1998350081,2
    C--733399(+) GAGAGG/ACCCAC 2 /A /V mis11Minor allele frequency- A:0.00EU 569
    rs2022180211,2
    --733407(+) CACTCA/GGTGAA 2 T syn10--------
    rs727734131,2
    C,F--733424(+) GTCCCC/GGAAGA 2 R G mis11Minor allele frequency- G:0.01EU 567
    rs1925258941,2
    --733429(+) CGAAGA/TAGTAC 2 Y F mis10--------
    rs740028251,2
    C--733441(+) GGGTGT/GCTGCC 2 /D /A mis12Minor allele frequency- G:0.09WA 120
    rs118637331,2
    C,F,H--733515(+) GCCGCC/GTAGGG 1 -- int12Minor allele frequency- G:0.02WA EU 525
    rs2017315341,2
    --733521(+) TAGGGA/CTGCCT 1 -- int10--------
    rs1834971201,2
    --733539(+) GCCCAA/GGGAGG 2 L syn10--------
    rs1876640881,2
    C--733572(+) CTGCTC/TCACAT 2 K E mis11Minor allele frequency- T:0.01EU 421

    HapMap Linkage Disequilibrium report for JMJD8 (731667 - 734529 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for JMJD8 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2487n71CNV Loss21882294
    nsv904796CNV Loss21882294
    dgv2492n71CNV Loss21882294
    nsv904797CNV Loss21882294
    dgv2493n71CNV Loss21882294
    nsv904759CNV Loss21882294
    dgv2479n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JMJD8
    DNA2.0 Custom Variant and Variant Library Synthesis for JMJD8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JMJD8 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with JMJD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339123 HGNC: 14148 AceView: DKFZp434F054andFBXL16andLOC339123 Ensembl:ENSG00000161999 euGenes: HUgn339123
    ECgene: JMJD8 H-InvDB: JMJD8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JMJD8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JMJD8 gene:
    Search GeneIP for patents involving JMJD8

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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