Free for academic non-profit institutions. Other users need a Commercial license

Aliases for JMJD8 Gene

Aliases for JMJD8 Gene

  • Jumonji Domain Containing 8 2 3 5
  • Jumonji Domain-Containing Protein 8 3 4
  • C16orf20 3 4
  • Chromosome 16 Open Reading Frame 20 2
  • JmjC Domain-Containing Protein 8 3
  • PP14397 3

External Ids for JMJD8 Gene

Previous HGNC Symbols for JMJD8 Gene

  • C16orf20

Previous GeneCards Identifiers for JMJD8 Gene

  • GC16M000673
  • GC16M000676
  • GC16M000731
  • GC16M000653

Summaries for JMJD8 Gene

GeneCards Summary for JMJD8 Gene

JMJD8 (Jumonji Domain Containing 8) is a Protein Coding gene.

Additional gene information for JMJD8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD8 Gene

Genomics for JMJD8 Gene

Regulatory Elements for JMJD8 Gene

Enhancers for JMJD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001308 1.4 ENCODE dbSUPER 131.4 -626.2 -626227 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001271 1.1 ENCODE 101.4 -587.3 -587299 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H000981 1.2 ENCODE dbSUPER 74.3 -296.9 -296948 0.2 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 KLF7 ZNF548 SP3 MCM3 WDR90 CRAMP1 ENSG00000261505 UBE2I JMJD8 TELO2 ENSG00000260954 UNKL ENSG00000260051 WDR24
GH16H000323 2 FANTOM5 Ensembl ENCODE dbSUPER 42.9 +358.1 358096 5.3 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF416 ZNF207 FOS WDR90 LUC7L JMJD8 UBE2I ENSG00000228779 ENSG00000261505 RHOT2 WDR24 ENSG00000262528 MPG
GH16H000635 1.4 ENCODE dbSUPER 39.9 +47.5 47456 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 METTL26 WDR90 CRAMP1 WFIKKN1 JMJD8 ENSG00000261505 UBE2I TELO2 NARFL ENSG00000226890
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JMJD8 on UCSC Golden Path with GeneCards custom track

Promoters for JMJD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082225 228 1001 PKNOX1 ARNT SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 ZNF548 DEK

Transcription factor binding sites by QIAGEN in the JMJD8 gene promoter:

Genomic Locations for JMJD8 Gene

Genomic Locations for JMJD8 Gene
2,862 bases
Minus strand

Genomic View for JMJD8 Gene

Genes around JMJD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD8 Gene

Proteins for JMJD8 Gene

  • Protein details for JMJD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    JmjC domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • B2RNS7
    • D3DU58
    • Q4PKE3
    • Q4VBY1
    • Q6GMW5
    • Q71RB8

    Protein attributes for JMJD8 Gene

    334 amino acids
    Molecular mass:
    36870 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI37101.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI37102.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15256.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for JMJD8 Gene


neXtProt entry for JMJD8 Gene

Post-translational modifications for JMJD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for JMJD8
  • Santa Cruz Biotechnology (SCBT) Antibodies for JMJD8

No data available for DME Specific Peptides for JMJD8 Gene

Domains & Families for JMJD8 Gene

Gene Families for JMJD8 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for JMJD8 Gene


Suggested Antigen Peptide Sequences for JMJD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JMJD8: view

No data available for UniProtKB/Swiss-Prot for JMJD8 Gene

Function for JMJD8 Gene

Phenotypes From GWAS Catalog for JMJD8 Gene

Phenotypes for JMJD8 Gene

genes like me logo Genes that share phenotypes with JMJD8: view

Animal Models for JMJD8 Gene

MGI Knock Outs for JMJD8:

Animal Model Products

miRNA for JMJD8 Gene

miRTarBase miRNAs that target JMJD8

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JMJD8 Gene

Localization for JMJD8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JMJD8 gene
Compartment Confidence
extracellular 5
mitochondrion 3
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for JMJD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with JMJD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for JMJD8 Gene

Pathways & Interactions for JMJD8 Gene

SuperPathways for JMJD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JMJD8 Gene


No data available for Pathways by source and SIGNOR curated interactions for JMJD8 Gene

Drugs & Compounds for JMJD8 Gene

No Compound Related Data Available

Transcripts for JMJD8 Gene

Unigene Clusters for JMJD8 Gene

Jumonji domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD8 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - - -

Relevant External Links for JMJD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JMJD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JMJD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JMJD8 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JMJD8 Gene

Protein tissue co-expression partners for JMJD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JMJD8 Gene:


SOURCE GeneReport for Unigene cluster for JMJD8 Gene:


Evidence on tissue expression from TISSUES for JMJD8 Gene

  • Kidney(4.3)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with JMJD8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JMJD8 Gene

Orthologs for JMJD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for JMJD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia JMJD8 33 34
  • 84.58 (n)
(Mus musculus)
Mammalia Jmjd8 33 16 34
  • 81.82 (n)
(Monodelphis domestica)
Mammalia JMJD8 34
  • 81 (a)
(Rattus norvegicus)
Mammalia Jmjd8 33
  • 80.85 (n)
(Bos Taurus)
Mammalia JMJD8 34
  • 79 (a)
(Gallus gallus)
Aves JMJD8 33
  • 77.27 (n)
gga-mir-6643 34
  • 71 (a)
(Anolis carolinensis)
Reptilia JMJD8 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498157 33
  • 68.18 (n)
Str.15601 33
(Danio rerio)
Actinopterygii LOC100330060 33
  • 64.84 (n)
CABZ01015475.1 34
  • 62 (a)
(Caenorhabditis elegans)
Secernentea C27F2.9 33 34
  • 50.98 (n)
Species where no ortholog for JMJD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JMJD8 Gene

Gene Tree for JMJD8 (if available)
Gene Tree for JMJD8 (if available)

Paralogs for JMJD8 Gene

No data available for Paralogs for JMJD8 Gene

Variants for JMJD8 Gene

Sequence variations from dbSNP and Humsavar for JMJD8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs587777340 Pathogenic 681,572(+) CCTAC(C/T)TCTCC intron-variant, upstream-variant-2KB, reference, missense
rs587777341 Pathogenic 681,468(+) GCTGA(A/T)CTTCG intron-variant, upstream-variant-2KB, reference, missense
rs587777342 Pathogenic 681,520(+) CGCTG(A/G/T)AACAG intron-variant, upstream-variant-2KB, reference, missense, stop-gained
rs587777343 Pathogenic 682,232(+) CATCA(C/T)GCCCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs587777344 Pathogenic 681,446(+) ACAGC(C/G/T)TGGCC intron-variant, upstream-variant-2KB, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for JMJD8 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv9321 CNV gain+loss 18304495
nsv827480 CNV gain 20364138
nsv571016 CNV loss 21841781
nsv571012 CNV loss 21841781
nsv526903 CNV loss 19592680
nsv516590 CNV loss 19592680
nsv482182 CNV gain 20164927
nsv482181 CNV gain 20164927
nsv471065 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv457311 CNV loss 19166990
nsv457310 CNV loss 19166990
nsv1160326 CNV duplication 26073780
nsv1160325 CNV duplication 26073780
esv2422427 CNV duplication 17116639
dgv4825n54 CNV loss 21841781

Variation tolerance for JMJD8 Gene

Gene Damage Index Score: 3.52; 55.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JMJD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD8 Gene

Disorders for JMJD8 Gene

Relevant External Links for JMJD8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JMJD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD8 Gene

Publications for JMJD8 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells. (PMID: 27199445) Boeckel JN … Dimmeler S (Arteriosclerosis, thrombosis, and vascular biology 2016) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 60

Products for JMJD8 Gene

Sources for JMJD8 Gene

Loading form....