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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JMJD8 Gene

protein-coding   GIFtS: 41
GCID: GC16M000731

Jumonji Domain Containing 8

(Previous name: chromosome 16 open reading frame 20)
(Previous symbol: C16orf20)
  Search for JMJD8
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Jumonji Domain Containing 81 2
C16orf201 2 3
Jumonji Domain-Containing Protein 82 3
Chromosome 16 Open Reading Frame 201
JmjC Domain-Containing Protein 82

External Ids:    HGNC: 141481   Entrez Gene: 3391232   Ensembl: ENSG000001619997   UniProtKB: Q96S163   

Export aliases for JMJD8 gene to outside databases

Previous GC identifers: GC16M000673 GC16M000676 GC16M000653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for JMJD8 Gene: 
JMJD8 (jumonji domain containing 8) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JMJD8 gene promoter:
         Sp1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJMJD8 promoter sequence
   Search SABiosciences Chromatin IP Primers for JMJD8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

JMJD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD8 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000731:  view genomic region     (about GC identifiers)

Start:
731,667 bp from pter      End:
734,529 bp from pter
Size:
2,863 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JMJD8_HUMAN, Q96S16 (See protein sequence)
Recommended Name: JmjC domain-containing protein 8  
Size: 334 amino acids; 36870 Da
Caution: It is uncertain whether Met-1 or Met-50 is the initiator
Sequence caution: Sequence=AAI37101.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI37102.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAQ15256.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RNS7 D3DU58 Q4PKE3 Q4VBY1 Q6GMW5 Q71RB8
Alternative splicing: 2 isoforms:  Q96S16-1   Q96S16-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JMJD8: NX_Q96S16

Explore proteomics data for JMJD8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96S16

  • JMJD8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JMJD8 Protein Expression
    REFSEQ proteins: NP_001005920.2  
    ENSEMBL proteins: 
     ENSP00000399475   ENSP00000454358   ENSP00000458106   ENSP00000454700   ENSP00000293882  
     ENSP00000394147  

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    Cloud-Clone Corp. CLIAs for JMJD8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q96S16

    ProtoNet protein and cluster: Q96S16

    UniProtKB/Swiss-Prot: JMJD8_HUMAN, Q96S16
    Similarity: Contains 1 JmjC domain


    JMJD8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    JMJD8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for JMJD8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JMJD8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JMJD8

    Search CenterWatch for drugs/clinical trials and news about JMJD8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JMJD8 gene: 
    NM_001005920.2  

    Unigene Cluster for JMJD8:

    Jumonji domain containing 8
    Hs.533771  [show with all ESTs]
    Unigene Representative Sequence: NM_001005920
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412368(uc002ciw.1 uc002ciy.1) ENST00000567120 ENST00000565302
    ENST00000568689 ENST00000568313 ENST00000569441 ENST00000562824 ENST00000563088
    ENST00000564436 ENST00000570037 ENST00000562111 ENST00000565258 ENST00000569396
    ENST00000566199 ENST00000567901 ENST00000293882 ENST00000454700
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate JMJD8:
    hsa-miR-138
    SwitchGear 3'UTR luciferase reporter plasmidJMJD8 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of JMJD8 
                         Customized lentivirus expression plasmids for stable overexpression of JMJD8 
    Primer
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    OriGene qPCR primer pairs and template standards for JMJD8
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD8

    Additional mRNA sequence: 

    AF370420.1 BC073785.1 BC094850.1 BC137100.1 BC137101.1 BC150144.1 DQ074695.1 

    17 DOTS entries:

    DT.100637940  DT.219419  DT.91788875  DT.95084511  DT.120670723  DT.100654787  DT.40264699  DT.92389737 
    DT.95084530  DT.100703078  DT.92452997  DT.447259  DT.100723261  DT.95084584  DT.95084510  DT.95205691 
    DT.99955565 

    24/590 AceView cDNA sequences (see all 590):

    BU552520 BU553730 BQ673080 AI025530 BQ581532 AW163613 AI991501 CR625506 
    NM_032259 AI399661 BM015643 BI767435 AL045079 BQ129331 T33027 AL563362 
    BM979638 CA390819 BF593699 AW959861 BQ898858 BC073785 AL136863 BQ639106 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD8 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -           -                 -                                                         
    SP2:        -     -     -     -           -                 -                                                         
    SP3:                          -                             -                                                         
    SP4:                          -           -                                                                           
    SP5:                          -                             -                                                         


    ECgene alternative splicing isoforms for JMJD8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JMJD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTGGGGG
    JMJD8 Expression
    About this image


    See JMJD8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JMJD8

    SOURCE GeneReport for Unigene cluster: Hs.533771
        SABiosciences Custom PCR Arrays for JMJD8
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for JMJD8 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jmjd81 , 5 jumonji domain containing 81, 5 80.72(n)1
    83.91(a)1
      17 (12.92 cM)5
    721061  NM_028101.41  NP_082377.21 
     258288675 
    chicken
    (Gallus gallus)
    Aves JMJD81 jumonji domain containing 8 76.73(n)
    75.29(a)
      426917  XM_424526.3  XP_424526.3 
    lizard
    (Anolis carolinensis)
    Reptilia JMJD86
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL344104.1(2275-21376)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156012 Transcribed sequence with weak similarity to protein more 76.82(n)    BX739808.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003300601 jmjC domain-containing protein 8-like 63.67(n)
    65.23(a)
      100330060  XM_003197992.1  XP_003198040.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C27F2.91 Protein C27F2.9 51.05(n)
    49.37(a)
      175673  NM_065652.4  NP_498053.2 


    ENSEMBL Gene Tree for JMJD8 (if available)
    TreeFam Gene Tree for JMJD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/52 SNPs in JMJD8 are shown (see all 52)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs455406371,2
    C--733292(+) AGCCTC/TAGTCC 1 -- int10--------
    rs1998350081,2
    C--733399(+) GAGAGG/ACCCAC 2 /A /V mis11Minor allele frequency- A:0.00EU 569
    rs2022180211,2
    --733407(+) CACTCA/GGTGAA 2 T syn10--------
    rs727734131,2
    C,F--733424(+) GTCCCC/GGAAGA 2 R G mis11Minor allele frequency- G:0.01EU 567
    rs1925258941,2
    --733429(+) CGAAGA/TAGTAC 2 Y F mis10--------
    rs740028251,2
    C--733441(+) GGGTGT/GCTGCC 2 /D /A mis12Minor allele frequency- G:0.09WA 120
    rs118637331,2
    C,F,H--733515(+) GCCGCC/GTAGGG 1 -- int12Minor allele frequency- G:0.02WA EU 525
    rs2017315341,2
    --733521(+) TAGGGA/CTGCCT 1 -- int10--------
    rs1834971201,2
    --733539(+) GCCCAA/GGGAGG 2 L syn10--------
    rs1876640881,2
    C--733572(+) CTGCTC/TCACAT 2 K E mis11Minor allele frequency- T:0.01EU 421

    HapMap Linkage Disequilibrium report for JMJD8 (731667 - 734529 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/29 variations for JMJD8 (see all 29):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2487n71CNV Loss21882294
    nsv904796CNV Loss21882294
    dgv2492n71CNV Loss21882294
    nsv904797CNV Loss21882294
    dgv2493n71CNV Loss21882294
    nsv904759CNV Loss21882294
    dgv2479n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JMJD8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with JMJD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    2. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339123 HGNC: 14148 AceView: DKFZp434F054andFBXL16andLOC339123 Ensembl:ENSG00000161999 euGenes: HUgn339123
    ECgene: JMJD8 H-InvDB: JMJD8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JMJD8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JMJD8 gene:
    Search GeneIP for patents involving JMJD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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     Regulatory tfbs in JMJD8 promoter
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     Proteins for JMJD8
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     Gene Synthesis
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     SwitchGear 3'UTR luciferase reporter plasmids for JMJD8
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     ThermoFisher Antibodies for JMJD8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for JMJD8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JMJD8
    Customized:
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     LSBio Antibodies in human, mouse, rat for JMJD8
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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