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Aliases for JMJD7-PLA2G4B Gene

Aliases for JMJD7-PLA2G4B Gene

  • JMJD7-PLA2G4B Readthrough 2 3 5
  • Jumonji Domain Containing 7-Phospholipase A2, Group IVB (Cytosolic) Read-Through 3
  • JMJD7-PLA2G4B Protein 3
  • CPLA2-Beta 3
  • HsT16992 3

External Ids for JMJD7-PLA2G4B Gene

Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene

  • GC15P039910
  • GC15P042122
  • GC15P018968

Summaries for JMJD7-PLA2G4B Gene

Entrez Gene Summary for JMJD7-PLA2G4B Gene

  • This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]

GeneCards Summary for JMJD7-PLA2G4B Gene

JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Oxytocin signaling pathway and Linoleic acid metabolism. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.

Gene Wiki entry for JMJD7-PLA2G4B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD7-PLA2G4B Gene

Genomics for JMJD7-PLA2G4B Gene

Regulatory Elements for JMJD7-PLA2G4B Gene

Enhancers for JMJD7-PLA2G4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F041925 1.7 FANTOM5 Ensembl ENCODE 10.9 +108.7 108741 23.4 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 BRCA1 YY1 GATA2 ZNF143 SPTBN5 EHD4 LOC105370792 LTK JMJD7 PLA2G4E-AS1 ENSG00000250379 JMJD7-PLA2G4B MAPKBP1 PLA2G4E
GH15F041786 1.3 Ensembl ENCODE 12.1 -35.6 -35612 11.0 ATF1 PKNOX1 CREB3L1 ARID4B ZNF48 ZNF121 ZNF143 FOS DEK ZNF263 JMJD7 TYRO3 SPTBN5 ENSG00000250379 JMJD7-PLA2G4B PLA2G4B LTK RPAP1 PPP1R14D ENSG00000279937
GH15F041772 1.1 ENCODE 11.9 -52.1 -52087 6.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 JMJD7 SPTBN5 ENSG00000250379 JMJD7-PLA2G4B LOC105370792 RPAP1 RNU6-1169P LTK PLA2G4B NDUFAF1
GH15F041800 0.9 Ensembl ENCODE 12.4 -23.8 -23825 7.0 ZNF263 CTCF TFAP4 CBX3 ZNF146 NFIA NFYC MNT ZIC2 RAD21 JMJD7 MAPKBP1 JMJD7-PLA2G4B ENSG00000250379 PLA2G4B LOC105370792 SPTBN5 TYRO3 RPAP1 RNU6-1169P
GH15F041779 0.9 Ensembl ENCODE 11.9 -47.8 -47785 1.8 SOX13 SCRT1 MXI1 L3MBTL2 SAP130 KLF6 FOXA3 DMAP1 MNT SCRT2 JMJD7 ENSG00000250379 JMJD7-PLA2G4B SPTBN5 LOC105370792 RPAP1 RNU6-1169P LTK ENSG00000279937 MAPKBP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track

Promoters for JMJD7-PLA2G4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000406869 115 2001 ATF1 ARID4B SIN3A ZNF48 ZNF2 YY1 GLIS2 SP3 MXD4 REST

Genomic Location for JMJD7-PLA2G4B Gene

Chromosome:
15
Start:
41,828,085 bp from pter
End:
41,848,155 bp from pter
Size:
20,071 bases
Orientation:
Plus strand

Genomic View for JMJD7-PLA2G4B Gene

Genes around JMJD7-PLA2G4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD7-PLA2G4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD7-PLA2G4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7-PLA2G4B Gene

Proteins for JMJD7-PLA2G4B Gene

  • Protein details for JMJD7-PLA2G4B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0Y9G9
    Recommended name:
    Protein JMJD7-PLA2G4B
    Protein Accession:
    H0Y9G9

    Protein attributes for JMJD7-PLA2G4B Gene

    Size:
    81 amino acids
    Molecular mass:
    9403 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JMJD7-PLA2G4B Gene

Protein Expression for JMJD7-PLA2G4B Gene

Post-translational modifications for JMJD7-PLA2G4B Gene

No Post-translational modifications

Other Protein References for JMJD7-PLA2G4B Gene

No data available for DME Specific Peptides for JMJD7-PLA2G4B Gene

Domains & Families for JMJD7-PLA2G4B Gene

Protein Domains for JMJD7-PLA2G4B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JMJD7-PLA2G4B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Function for JMJD7-PLA2G4B Gene

genes like me logo Genes that share phenotypes with JMJD7-PLA2G4B: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7-PLA2G4B Gene

Localization for JMJD7-PLA2G4B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JMJD7-PLA2G4B Gene

Pathways & Interactions for JMJD7-PLA2G4B Gene

genes like me logo Genes that share pathways with JMJD7-PLA2G4B: view

Interacting Proteins for JMJD7-PLA2G4B Gene

Gene Ontology (GO) - Biological Process for JMJD7-PLA2G4B Gene

None

No data available for SIGNOR curated interactions for JMJD7-PLA2G4B Gene

Transcripts for JMJD7-PLA2G4B Gene

Unigene Clusters for JMJD7-PLA2G4B Gene

JMJD7-PLA2G4B readthrough:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7-PLA2G4B Gene

No ASD Table

Relevant External Links for JMJD7-PLA2G4B Gene

GeneLoc Exon Structure for
JMJD7-PLA2G4B
ECgene alternative splicing isoforms for
JMJD7-PLA2G4B

Expression for JMJD7-PLA2G4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for JMJD7-PLA2G4B Gene

Protein differential expression in normal tissues from HIPED for JMJD7-PLA2G4B Gene

This gene is overexpressed in Cervix (33.0) and Urine (32.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for JMJD7-PLA2G4B Gene



Protein tissue co-expression partners for JMJD7-PLA2G4B Gene

SOURCE GeneReport for Unigene cluster for JMJD7-PLA2G4B Gene:

Hs.198161
genes like me logo Genes that share expression patterns with JMJD7-PLA2G4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JMJD7-PLA2G4B Gene

Orthologs for JMJD7-PLA2G4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for JMJD7-PLA2G4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PLA2G4B 35
  • 84 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pla2g4b 35
  • 84 (a)
ManyToMany
PLA2G4B 35
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia PLA2G4B 35
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
Species where no ortholog for JMJD7-PLA2G4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JMJD7-PLA2G4B Gene

ENSEMBL:
Gene Tree for JMJD7-PLA2G4B (if available)
TreeFam:
Gene Tree for JMJD7-PLA2G4B (if available)

Paralogs for JMJD7-PLA2G4B Gene

Paralogs for JMJD7-PLA2G4B Gene

(1) SIMAP similar genes for JMJD7-PLA2G4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JMJD7-PLA2G4B: view

Variants for JMJD7-PLA2G4B Gene

Sequence variations from dbSNP and Humsavar for JMJD7-PLA2G4B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1043627 -- 41,827,702(-) AAACA(A/G)GGCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1055827 -- 41,848,327(-) GTGGC(C/T)TCCTC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1061354 -- 41,847,968(+) GGCAC(G/T)GTCCC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10634609 -- 41,827,126(+) CCTGT(-/CT/TC)CTACT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs11070350 -- 41,835,720(+) AGTGG(A/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JMJD7-PLA2G4B Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
esv2760027 CNV loss 17122850
nsv977704 CNV duplication 23825009
nsv952613 CNV deletion 24416366
nsv9244 CNV gain 18304495
nsv517631 CNV loss 19592680
nsv1506 CNV insertion 18451855
nsv1050892 CNV gain 25217958
nsv1038933 CNV gain 25217958
nsv1035998 CNV gain 25217958
esv3636251 CNV loss 21293372

Variation tolerance for JMJD7-PLA2G4B Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JMJD7-PLA2G4B Gene

Human Gene Mutation Database (HGMD)
JMJD7-PLA2G4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
JMJD7-PLA2G4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Disorders for JMJD7-PLA2G4B Gene

Relevant External Links for JMJD7-PLA2G4B

Human Genome Epidemiology (HuGE) Navigator
JMJD7-PLA2G4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JMJD7-PLA2G4B

No disorders were found for JMJD7-PLA2G4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7-PLA2G4B Gene

Publications for JMJD7-PLA2G4B Gene

  1. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M. … Leslie C.C. (J. Biol. Chem. 2006) 3 22 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 64
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for JMJD7-PLA2G4B Gene

Sources for JMJD7-PLA2G4B Gene

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