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Aliases for JMJD7-PLA2G4B Gene

Aliases for JMJD7-PLA2G4B Gene

  • JMJD7-PLA2G4B Readthrough 2 3
  • CPLA2-Beta 3 4
  • EC 3.1.1.4 4 63
  • Jumonji Domain Containing 7-Phospholipase A2, Group IVB (Cytosolic) Read-Through 3
  • Phospholipase A2 Group IVB 4
  • JMJD7-PLA2G4B Protein 3
  • HsT16992 3
  • PLA2G4B 4

External Ids for JMJD7-PLA2G4B Gene

Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene

  • GC15P039910
  • GC15P042122
  • GC15P018968

Summaries for JMJD7-PLA2G4B Gene

Entrez Gene Summary for JMJD7-PLA2G4B Gene

  • This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]

GeneCards Summary for JMJD7-PLA2G4B Gene

JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Ras signaling pathway. An important paralog of this gene is PLA2G4C.

UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

  • Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.

Gene Wiki entry for JMJD7-PLA2G4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD7-PLA2G4B Gene

Genomics for JMJD7-PLA2G4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for JMJD7-PLA2G4B Gene

Start:
41,828,085 bp from pter
End:
41,848,155 bp from pter
Size:
20,071 bases
Orientation:
Plus strand

Genomic View for JMJD7-PLA2G4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JMJD7-PLA2G4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7-PLA2G4B Gene

No data available for Regulatory Elements for JMJD7-PLA2G4B Gene

Proteins for JMJD7-PLA2G4B Gene

  • Protein details for JMJD7-PLA2G4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C869-PA24B_HUMAN
    Recommended name:
    Cytosolic phospholipase A2 beta
    Protein Accession:
    P0C869
    Secondary Accessions:
    • B4DRT9
    • O95712
    • Q19KD5
    • Q19KD6
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for JMJD7-PLA2G4B Gene

    Size:
    781 amino acids
    Molecular mass:
    87978 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92387.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for JMJD7-PLA2G4B Gene

neXtProt entry for JMJD7-PLA2G4B Gene

Proteomics data for JMJD7-PLA2G4B Gene at MOPED

Protein Expression for JMJD7-PLA2G4B Gene

Selected DME Specific Peptides for JMJD7-PLA2G4B Gene

Post-translational modifications for JMJD7-PLA2G4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMJD7-PLA2G4B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for JMJD7-PLA2G4B Gene

Protein Domains for JMJD7-PLA2G4B Gene

Graphical View of Domain Structure for InterPro Entry

P0C869

UniProtKB/Swiss-Prot:

PA24B_HUMAN :
  • P0C869
Domain:
  • The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
  • Contains 1 C2 domain.
  • Contains 1 PLA2c domain.
genes like me logo Genes that share domains with JMJD7-PLA2G4B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for JMJD7-PLA2G4B Gene

Function for JMJD7-PLA2G4B Gene

Molecular function for JMJD7-PLA2G4B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: Vmax=7.9 pmol/min/mg enzyme (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) {ECO:0000269 PubMed:10085124}; Vmax=140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) {ECO:0000269 PubMed:10085124}; Vmax=2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) {ECO:0000269 PubMed:10085124}; Vmax=0.8 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) {ECO:0000269 PubMed:10085124}; Vmax=0.3 nmol/min/ug enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3) {ECO:0000269 PubMed:10085124};
UniProtKB/Swiss-Prot CatalyticActivity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot EnzymeRegulation: Stimulated by cytosolic Ca(2+).
UniProtKB/Swiss-Prot Function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.

Enzyme Numbers (IUBMB) for JMJD7-PLA2G4B Gene

Gene Ontology (GO) - Molecular Function for JMJD7-PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity --
GO:0004622 lysophospholipase activity --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding --
genes like me logo Genes that share ontologies with JMJD7-PLA2G4B: view

Phenotypes for JMJD7-PLA2G4B Gene

GenomeRNAi human phenotypes for JMJD7-PLA2G4B:
genes like me logo Genes that share phenotypes with JMJD7-PLA2G4B: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for JMJD7-PLA2G4B Gene

Localization for JMJD7-PLA2G4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Cytoplasm, cytosol.
Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JMJD7-PLA2G4B Gene COMPARTMENTS Subcellular localization image for JMJD7-PLA2G4B gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
mitochondrion 5
nucleus 2

Gene Ontology (GO) - Cellular Components for JMJD7-PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005743 mitochondrial inner membrane --
GO:0005768 endosome --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with JMJD7-PLA2G4B: view

Pathways for JMJD7-PLA2G4B Gene

genes like me logo Genes that share pathways with JMJD7-PLA2G4B: view

Interacting Proteins for JMJD7-PLA2G4B Gene

Gene Ontology (GO) - Biological Process for JMJD7-PLA2G4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process --
GO:0006654 phosphatidic acid biosynthetic process --
GO:0006954 inflammatory response --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0007567 parturition --
genes like me logo Genes that share ontologies with JMJD7-PLA2G4B: view

Transcripts for JMJD7-PLA2G4B Gene

Unigene Clusters for JMJD7-PLA2G4B Gene

JMJD7-PLA2G4B readthrough:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JMJD7-PLA2G4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for JMJD7-PLA2G4B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7-PLA2G4B Gene

No ASD Table

Relevant External Links for JMJD7-PLA2G4B Gene

GeneLoc Exon Structure for
JMJD7-PLA2G4B
ECgene alternative splicing isoforms for
JMJD7-PLA2G4B

Expression for JMJD7-PLA2G4B Gene

mRNA expression in normal human tissues for JMJD7-PLA2G4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JMJD7-PLA2G4B Gene

SOURCE GeneReport for Unigene cluster for JMJD7-PLA2G4B Gene Hs.198161

mRNA Expression by UniProt/SwissProt for JMJD7-PLA2G4B Gene

P0C869-PA24B_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed.
genes like me logo Genes that share expressions with JMJD7-PLA2G4B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for JMJD7-PLA2G4B Gene

Orthologs for JMJD7-PLA2G4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for JMJD7-PLA2G4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
ManyToMany
-- 36
  • 98 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PLA2G4B 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PLA2G4B 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pla2g4b 16
Pla2g4b 36
  • 84 (a)
ManyToMany
PLA2G4B 36
  • 81 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
Species with no ortholog for JMJD7-PLA2G4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JMJD7-PLA2G4B Gene

ENSEMBL:
Gene Tree for JMJD7-PLA2G4B (if available)
TreeFam:
Gene Tree for JMJD7-PLA2G4B (if available)

Paralogs for JMJD7-PLA2G4B Gene

Paralogs for JMJD7-PLA2G4B Gene

Selected SIMAP similar genes for JMJD7-PLA2G4B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JMJD7-PLA2G4B: view

Variants for JMJD7-PLA2G4B Gene

Structural Variations from Database of Genomic Variants (DGV) for JMJD7-PLA2G4B Gene

Variant ID Type Subtype PubMed ID
dgv740e1 CNV Complex 17122850
nsv904115 CNV Loss 21882294
nsv904116 CNV Loss 21882294
nsv517631 CNV Loss 19592680
dgv2364n71 CNV Loss 21882294
nsv904119 CNV Loss 21882294
dgv2365n71 CNV Loss 21882294
nsv9244 CNV Gain 18304495
nsv1506 CNV Insertion 18451855
nsv904126 CNV Loss 21882294

Relevant External Links for JMJD7-PLA2G4B Gene

HapMap Linkage Disequilibrium report
JMJD7-PLA2G4B
Human Gene Mutation Database (HGMD)
JMJD7-PLA2G4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for JMJD7-PLA2G4B Gene

Disorders for JMJD7-PLA2G4B Gene

Relevant External Links for JMJD7-PLA2G4B

Human Genome Epidemiology (HuGE) Navigator
JMJD7-PLA2G4B
genes like me logo Genes that share disorders with JMJD7-PLA2G4B: view

No data available for UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene

Publications for JMJD7-PLA2G4B Gene

  1. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M. … Leslie C.C. (J. Biol. Chem. 2006) 3 4 23
  2. Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. (PMID: 10085124) Pickard R.T. … Sharp J.D. (J. Biol. Chem. 1999) 3 4
  3. Molecular characterization of cytosolic phospholipase A2-beta. (PMID: 10358058) Song C. … Kriz R.W. (J. Biol. Chem. 1999) 3 4
  4. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. (PMID: 11741884) Degousee N. … Rubin B.B. (J. Biol. Chem. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for JMJD7-PLA2G4B Gene

Sources for JMJD7-PLA2G4B Gene

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