Aliases for JMJD7-PLA2G4B Gene
External Ids for JMJD7-PLA2G4B Gene
Previous GeneCards Identifiers for JMJD7-PLA2G4B Gene
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
GeneCards Summary for JMJD7-PLA2G4B Gene
JMJD7-PLA2G4B (JMJD7-PLA2G4B Readthrough) is a Protein Coding gene. Among its related pathways are Platelet activation and Linoleic acid metabolism. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G4B.
UniProtKB/Swiss-Prot for JMJD7-PLA2G4B Gene
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine.