JMJD7 Gene
protein-coding GIFtS: 35
GCID: GC15P042121
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jumonji domain containing 7
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Aliases
for JMJD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jumonji Domain Containing 71 2 | | Jumonji Domain-Containing Protein 72 3 | | JmjC Domain-Containing Protein 72 |
Export aliases for JMJD7 gene to outside databasesPrevious GC identifers: GC15U900840 GC15P039909 GC15P018969 |
Summaries
for JMJD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for JMJD7:
This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily.JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-throughtranscripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encodefusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. (provided byRefSeq, Jul 2008)
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Genomic Views
for JMJD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JMJD7 gene promoter:
NRSF form 1 AP-2gamma NRSF form 2 c-Ets-1 GATA-1 STAT3 SEF-1 (1) c-Myb Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for JMJD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1JMJD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P042121: view genomic region
(about GC identifiers)
Start:
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42,120,283 bp from pter |
End:
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42,129,785 bp from pter |
Size:
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9,503 bases |
Orientation:
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plus strand |
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Proteins
for JMJD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JMJD7_HUMAN, P0C870 (See
protein sequence)Recommended Name: JmjC domain-containing protein 7 Size: 316 amino acids; 35932 Da
Caution: This sequence was first thought to be an alternatively spliced isoform of PLA2G4B. It is derived from JMJD7which is located upstream of PLA2G4B. Most tissues also express read-through transcripts from JMJD7 into thedownstream PLA2G4B gene, some of which may encode fusion proteins combining the N-terminus of this protein withPLA2G4B protein
Secondary accessions: A5D6V5 O95712 Q59GF9 Q8TB10 Q9UKV7Explore the universe of human proteins at neXtProt for JMJD7: NX_P0C870
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0C870
JMJD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001108104.1
ENSEMBL proteins: ENSP00000380467 ENSP00000384174 ENSP00000399600
Human Recombinant Protein Products:
JMJD7 Antibody Products:
Assay Products for JMJD7: |
Protein
Domains /
Families
for JMJD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JMJD7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0C870ProtoNet protein and cluster: P0C870 UniProtKB/Swiss-Prot: JMJD7_HUMAN, P0C870Similarity: Contains 1 JmjC domain |
Function
for JMJD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): JMJD7 (NM_005090) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JMJD7 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JMJD7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD7 |
|
Pathways & Interactions
for JMJD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JMJD7
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
4 Interacting proteins for JMJD7 (P0C8703 ENSP000003804674) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for JMJD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JMJD7
Search CenterWatch for drugs/clinical trials and news about JMJD7
|
Transcripts
for JMJD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JMJD7 gene: NM_001114632.1 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397299(uc001zop.1) ENST00000408047(uc001zom.2) ENST00000431823
ENST00000405106(uc010bcm.1) ENST00000562035 ENST00000478178
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): JMJD7 (NM_005090) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JMJD7 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JMJD7 |
GeneLoc Exon Structure
|
Expression
for JMJD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JMJD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See JMJD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JMJD7
SABiosciences Custom PCR Arrays for JMJD7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat JMJD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD7 |
Orthologs
for JMJD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for JMJD7 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for JMJD7 (if available)
TreeFam Gene Tree for JMJD7 (if available) |
Paralogs
for JMJD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JMJD7 gene
- TYW52 HSPBAP12 KDM82 HIF1AN2
1 SIMAP similar gene for JMJD7 using alignment to 3 protein entries: JMJD7_HUMAN (see all proteins):JMJD7-PLA2G4B
JMJD7 for paralogs About GeneDecksing
|
Genomic Variants
for JMJD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for JMJD7
2 CNVs: 3078 30707 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD7 |
|
Disorders
/ Diseases
for JMJD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JMJD7 for disorders About GeneDecksing
1  disease for JMJD7: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: JMJD7 (3 documents)
Export disorders for JMJD7 gene to outside databases
|
Publications
for JMJD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JMJD7 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with JMJD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PubMed id 16617059)1 Ghosh M.... Leslie C.C. (2006)
- Methylation: lost in hydroxylation? (PubMed id 15809658)1 Trewick S.C....Allshire R.C. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2. (PubMed id 10085124)1 Pickard R.T.... Sharp J.D. (1999)
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External Searches for JMJD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing JMJD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing JMJD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JMJD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JMJD7 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for JMJD7 gene:
Search GeneIP for patents involving JMJD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JMJD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for JMJD7 | | OriGene shRNA RFP for JMJD7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JMJD7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD7 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for JMJD7 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for JMJD7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for JMJD7 | | OriGene Custom Protein Services for JMJD7 | | | OriGene Custom Immunoassay Development | | |
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| | | | Search Tocris compounds for JMJD7 |
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 | | | JMJD7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD7 |
|  |  |  | | | | ThermoFisher Antibody for JMJD7 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JMJD7 |
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