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Aliases for JMJD7 Gene

Aliases for JMJD7 Gene

  • Jumonji Domain Containing 7 2 3 5
  • Jumonji Domain-Containing Protein 7 4

External Ids for JMJD7 Gene

Previous GeneCards Identifiers for JMJD7 Gene

  • GC15U900840
  • GC15P039909
  • GC15P042121
  • GC15P018969

Summaries for JMJD7 Gene

Entrez Gene Summary for JMJD7 Gene

  • This gene encodes a highly conserved protein with a JmjC domain, which are part of the cupin metalloenzyme superfamily. JmjC proteins may function as 2-oxoglutarate-Fe(II)-dependent dioxygenases. Most tissues also express read-through transcripts from this gene into the downstream phospholipase A2, group IVB (cytosolic) gene, some of which may encode fusion proteins combining the N-terminus of this protein with the phospholipase A2, group IVB protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for JMJD7 Gene

JMJD7 (Jumonji Domain Containing 7) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD7 Gene

Genomics for JMJD7 Gene

Regulatory Elements for JMJD7 Gene

Promoters for JMJD7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JMJD7 on UCSC Golden Path with GeneCards custom track

Genomic Location for JMJD7 Gene

Chromosome:
15
Start:
41,828,085 bp from pter
End:
41,837,587 bp from pter
Size:
9,503 bases
Orientation:
Plus strand

Genomic View for JMJD7 Gene

Genes around JMJD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JMJD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JMJD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD7 Gene

Proteins for JMJD7 Gene

  • Protein details for JMJD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C870-JMJD7_HUMAN
    Recommended name:
    JmjC domain-containing protein 7
    Protein Accession:
    P0C870
    Secondary Accessions:
    • A5D6V5
    • O95712
    • Q59GF9
    • Q8TB10
    • Q9UKV7

    Protein attributes for JMJD7 Gene

    Size:
    316 amino acids
    Molecular mass:
    35932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JMJD7 Gene

Proteomics data for JMJD7 Gene at MOPED

Post-translational modifications for JMJD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMJD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for JMJD7 Gene

Domains & Families for JMJD7 Gene

Protein Domains for JMJD7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JMJD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C870

UniProtKB/Swiss-Prot:

JMJD7_HUMAN :
  • Contains 1 JmjC domain.
Domain:
  • Contains 1 JmjC domain.
genes like me logo Genes that share domains with JMJD7: view

No data available for Gene Families for JMJD7 Gene

Function for JMJD7 Gene

Phenotypes for JMJD7 Gene

GenomeRNAi human phenotypes for JMJD7:
genes like me logo Genes that share phenotypes with JMJD7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JMJD7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for JMJD7 Gene

Localization for JMJD7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JMJD7 Gene COMPARTMENTS Subcellular localization image for JMJD7 gene
Compartment Confidence
cytosol 5
endosome 5
extracellular 5
mitochondrion 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for JMJD7 Gene

Pathways & Interactions for JMJD7 Gene

SuperPathways for JMJD7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JMJD7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JMJD7 Gene

Drugs & Compounds for JMJD7 Gene

No Compound Related Data Available

Transcripts for JMJD7 Gene

mRNA/cDNA for JMJD7 Gene

(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD7 Gene

No ASD Table

Relevant External Links for JMJD7 Gene

GeneLoc Exon Structure for
JMJD7
ECgene alternative splicing isoforms for
JMJD7

Expression for JMJD7 Gene

mRNA expression in normal human tissues for JMJD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JMJD7 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for JMJD7 Gene

This gene is overexpressed in Heart (13.5), Cervix (9.8), Salivary gland (8.8), and Retina (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for JMJD7 Gene



genes like me logo Genes that share expression patterns with JMJD7: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for JMJD7 Gene

Orthologs for JMJD7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for JMJD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
JMJD7 35
  • 98.84 (n)
  • 97.78 (a)
cow
(Bos Taurus)
Mammalia JMJD7 36
  • 93 (a)
OneToOne
JMJD7 35
  • 89.03 (n)
  • 93.04 (a)
dog
(Canis familiaris)
Mammalia JMJD7 35
  • 88.82 (n)
  • 92.41 (a)
JMJD7 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jmjd7 16
Jmjd7 36
  • 90 (a)
OneToOne
Jmjd7 35
  • 85.23 (n)
  • 89.87 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia JMJD7 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jmjd7 35
  • 85.44 (n)
  • 89.56 (a)
chicken
(Gallus gallus)
Aves JMJD7 35
  • 65.92 (n)
  • 70.51 (a)
JMJD7 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JMJD7 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jmjd7 35
  • 65.38 (n)
  • 67.85 (a)
zebrafish
(Danio rerio)
Actinopterygii jmjd7 36
  • 65 (a)
OneToOne
jmjd7 35
  • 66.67 (n)
  • 65.7 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007766 35
  • 52.51 (n)
  • 42.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10133 35
  • 53.79 (n)
  • 46.9 (a)
CG10133 36
  • 44 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45880 35
  • 49.51 (n)
  • 42.3 (a)
rice
(Oryza sativa)
Liliopsida Os09g0483600 35
  • 56.82 (n)
  • 47.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03670 35
  • 45.5 (n)
  • 33.58 (a)
Species with no ortholog for JMJD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JMJD7 Gene

ENSEMBL:
Gene Tree for JMJD7 (if available)
TreeFam:
Gene Tree for JMJD7 (if available)

Paralogs for JMJD7 Gene

(1) SIMAP similar genes for JMJD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JMJD7: view

No data available for Paralogs for JMJD7 Gene

Variants for JMJD7 Gene

Sequence variations from dbSNP and Humsavar for JMJD7 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_027046 -
VAR_069392 -

Structural Variations from Database of Genomic Variants (DGV) for JMJD7 Gene

Variant ID Type Subtype PubMed ID
dgv740e1 CNV Complex 17122850
nsv904115 CNV Loss 21882294
nsv904116 CNV Loss 21882294
nsv517631 CNV Loss 19592680
dgv2364n71 CNV Loss 21882294
nsv904119 CNV Loss 21882294
dgv2365n71 CNV Loss 21882294
nsv9244 CNV Gain 18304495
nsv1506 CNV Insertion 18451855

Variation tolerance for JMJD7 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.92; 59.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JMJD7 Gene

HapMap Linkage Disequilibrium report
JMJD7
Human Gene Mutation Database (HGMD)
JMJD7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD7 Gene

Disorders for JMJD7 Gene

Relevant External Links for JMJD7

Genetic Association Database (GAD)
JMJD7
Human Genome Epidemiology (HuGE) Navigator
JMJD7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JMJD7

No disorders were found for JMJD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JMJD7 Gene

Publications for JMJD7 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. (PMID: 16617059) Ghosh M. … Leslie C.C. (J. Biol. Chem. 2006) 3

Products for JMJD7 Gene

Sources for JMJD7 Gene

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