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JMJD6 Gene

protein-coding GIFtS: 51

GC17M072221

jumonji domain containing 6
(Previous name: phosphatidylserine receptor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PTDSR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.11.- ^³
KIAA0585 ^¹, ², ³
PSR ^², ⁵
PTDSR ^², ³
PTDSR1 ^¹, ²

Descriptions
JmjC domain-containing protein 6 ^³
Jumonji domain-containing protein 6 ^³
Phosphatidylserine receptor ^¹, ², ³
Protein PTDSR ^³
jumonji domain containing 6 ^²

External Ids
HGNC: 19355¹
Entrez Gene: 23210²
UniProtKB: Q6NYC1³
Ensembl: ENSG00000070495⁷

Search outside databases for aliases for JMJD6 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for JMJD6:

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are

predicted to function as protein hydroxylases or histone demethylases. This protein was first

identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells;

however, subsequent studies have indicated that it does not directly function in the clearance of

apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1

Function: Arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at

'Arg-3' (H4R3me). Required for differentiation of multiple organs during embryogenesis. Probably

acts as a key regulator of hematopoietic differentiation. Seems to be necessary for the regulation

of macrophage cytokine responses

Gene Wiki entry for JMJD6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.2 HGNC cytogenetic band: 17q25

JMJD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M072221: (about GC identifiers)

Start:	72,220,509 bp from pter
End:	72,234,476 bp from pter
Size:	13,968 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010641.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1 (See protein sequence)

Recommended Name: Histone arginine demethylase JMJD6

Size: 403 amino acids; 46462 Da

Subcellular location: Nucleus

Caution: Was initially thought to constitute the phosphatidylserine receptor, a receptor that

mediates recognition of phosphatidylserine, a specific marker only present at the surface of

apoptotic cells. Phosphatidylserine receptor probably participates in apoptotic cell phagocytosis.

This protein was identified using phage display expressing mAb 217, an antibody that specifically

recognizes phosphatidylserine receptor. However, its nuclear localization and the fact that mAb

217 antibody still recognizes the phosphatidylserine receptor in mice lacking JMJD6, strongly

suggest that it does not constitute the receptor for phosphatidylserine and is not involved in

apoptotic cell removal

Secondary accessions: Q86VY0 Q8IUM5 Q9Y4E2

Alternative splicing: 3 isoforms: Q6NYC1-1 Q6NYC1-2 Q6NYC1-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001074930.1 NP_055982.2

ENSEMBL proteins:

ENSP00000345857 ENSP00000302916 ENSP00000380750

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (JMJD6)
	Human Recombinant Proteins from Abnova (PTDSR)

OriGene Purified Recombinant Human Protein: JMJD6

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	14729065
GO:0005886	plasma membrane	IEA	--

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Antibodies for JMJD6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for JMJD6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (JMJD6), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PTDSR)
	Novus Biologicals Antibody for JMJD6

Assays for JMJD6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6NYC1

ProtoNet protein and cluster: Q6NYC1

UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1

Domain: The nuclear localization signal motifs are necessary and sufficient to target it into the

nucleus

Similarity: Belongs to the PTDSR family

Similarity: Contains 1 JmjC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JMJD6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTDSR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015167

Applied Biosystems Silencer® siRNAs for JMJD6

Sigma-Aldrich siRNA for JMJD6

Sigma-Aldrich shRNA for JMJD6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for JMJD6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081461
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081461
untagged cDNA clones in CMV expression vector (see all 3): NM_001081461

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001081461

UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1

Function: Arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at

'Arg-3' (H4R3me). Required for differentiation of multiple organs during embryogenesis. Probably

acts as a key regulator of hematopoietic differentiation. Seems to be necessary for the regulation

of macrophage cytokine responses

Induction: Up-regulated upon cytokine treatment, but not upon TNF-alpha treatment

Enzyme Number (IUBMB): EC 1.14.11.-

15/17 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Jmjd6) (see all 17 ):

	cellular	craniofacial	digestive/alimentary	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-prenatal/perinatal	liver/biliary system
muscle	nervous system	no phenotypic analysis	renal/urinary system	respiratory system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--
GO:0033746	histone demethylase activity (H3-R2 specific)	IDA	17947579
GO:0033749	histone demethylase activity (H4-R3 specific)	IDA	17947579

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for JMJD6 (Your Favorite Gene powered by Ingenuity)

IL-12 Signaling and Production in Macrophages

GeneDecks JMJD6 for the pathways selected above

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2 Interacting proteins for JMJD6 (ENSP00000302916³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DOCK1	ENSP00000280333³	STRING (score=.795)
CTDSP2	ENSP00000309934³	STRING (score=.716)

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5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001568	blood vessel development	IEA	--
GO:0001822	kidney development	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0007166	cell surface receptor linked signal transduction	IEA	--
GO:0007275	multicellular organismal development	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JMJD6
3 Novoseek chemical compound relationships for JMJD6 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphoserine	59.04	2	10936187 (1), 7583670 (1)
phospholipid	27.76	2	9915844 (1), 7583670 (1)
lipid	4.78	1	10936187 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JMJD6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PTDSR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015167

Sigma-Aldrich siRNA for JMJD6

Sigma-Aldrich shRNA for JMJD6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001081461 NM_015167

REFSEQ mRNAs for JMJD6 gene (2 alternative transcripts):

NM_001081461.1 NM_015167.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001081461 NM_015167

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081461
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081461
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001081461

Additional cDNA sequence:

AB011157.1 AB073711.1 AK021780.1 AK294816.1 AK314541.1 BC016837.1 BC047003.1 BC066654.1

CR594304.1 CR597139.1 CR598927.1 CR600929.1 CR601337.1 CR602714.1 CR609667.1 CR613854.1

EF527406.1 EF527407.1

15 DOTS entries:

DT.100701748 DT.95298523 DT.100812905 DT.316217 DT.100812903 DT.120924927 DT.91824600 DT.203158

DT.95298519 DT.100812912 DT.100812901 DT.100812900 DT.100812909 DT.120925009 DT.95298521

24/263 AceView cDNA sequences (see all 263 ):

BM687017 BM916892 AB011157 CR609667 BC016837 AI253789 AI682172 AI926454

AI026025 CR594304 BP375107 BQ669508 CR601337 BQ639908 BI910055 CB529456

BQ223112 BI759425 AI078362 BQ672747 CD673337 BQ426076 BQ002475 BQ668503

Unigene Cluster for JMJD6:

Jumonji domain containing 6

Hs.514505 [show with all ESTs]

Unigene Representative Sequence: NM_001081461

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD6

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7
SP1:											-
SP2:

About this scheme

ECgene alternative splicing isoforms for JMJD6

3 Ensembl transcripts including schematic representations:

ENST00000344991 ENST00000303996 ENST00000397625

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JMJD6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JMJD6

¹ / ²

10 probe-sets matching JMJD6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35851_g_at²	U95-A	1	1.00	1.00	0.76	0.89	--	--	--	--	--
35849_at²	U95-A	1	1.00	1.00	0.14	0.96	--	--	--	--	--
35850_at²	U95-A	2	1.00	0.97	0.83	1.17	--	--	--	--	--
212723_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
215233_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212722_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212723_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215233_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552629_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212722_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks JMJD6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGGAAACG

SOURCE GeneReport for Unigene cluster: Hs.514505
UniProtKB/Swiss-Prot: JMJD6_HUMAN, Q6NYC1
Tissue specificity: Highly expressed in the heart, skeletal muscle and kidney. Expressed at
moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis
and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic
epithelial cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JMJD6 gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JMJD6¹	--	jumonji domain containing 6	92.56(n) 98.26(a)	483335 XM_843987.1 XP_849080.1
chimpanzee (Pan troglodytes)	JMJD6¹	--	jumonji domain containing 6	99.76(n) 100(a)	468338 XM_001153530.1 XP_001153530.1
cow (Bos taurus)	JMJD6¹	--	jumonji domain containing 6	92.36(n) 98.34(a)	508343 NM_001034320.1 NP_001029492.1
rat (Rattus norvegicus)	Jmjd6¹	--	jumonji domain containing 6	90.81(n) 98.01(a)	360665 NM_001012143.1 NP_001012143.1
mouse (Mus musculus)	Jmjd6^{1, 5}	11 (75.00 cM)⁵	jumonji domain containing 6^{1, 5}	89.99(n)¹ 97.77(a)¹	107817¹ NM_033398.2¹ NP_203971.2¹ AA794134⁵ AF304118⁵ (see all 22)

About this table Species with no ortholog for JMJD6

ENSEMBL Gene Tree for JMJD6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JMJD6 gene

JMJD4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/63 NCBI SNPs in JMJD6 are shown (see all 63 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 33)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2286585^1,2	A,C,F,H,O	72223905(-)	`CTGTAT/CGTCAT`	1	--	ut3¹ ese³		9		EA EU WA NA	2236
	rs2240775^1,2	A,C,F,H	72221723(-)	`TCTTAA/GTAATT`	1	--	ut3¹		8		EU EA WA NA	762
	rs2240774^1,2	A,C,F,H	72222167(-)	`GGCCAA/GGGTAG`	1	--	ut3¹		13		EA EU WA	2756
	rs2240773^1,2	C,F,H,O	72222378(-)	`AGTCAG/TCTCTG`	1	--	ut3¹		5		EA EU WA	1912
	rs2240772^1,2	A,C,F,H	72223318(-)	`GAGGCA/GTTGGC`	1	--	ut3¹		7		EA EU WA NA	1680
--	rs3217059^1,2	C	72223754(-)	`TTTTT-/TGTGGG`	1	--	ut3¹		0	--	--	--	--
	rs1014390^1,2	A,C,F,H,O	72224481(-)	`GGGTCC/TTGCTT`	1	--	int¹		7		EU EA WA MN	3148
	rs2240769^1,2	C,F,H,O	72229750(-)	`TCCCTG/AGATCA`	2	--	int¹		13		EU EA WA NA	2658
	rs7224225^1,2	A,C,F,H	72229658(+)	`TACCTA/TATTAC`	2	--	int¹		4		EU EA WA	412
	rs2286584^1,2	A,C,F	72224600(-)	`TTTAAA/TTTGTT`	1	--	int¹		2		MN EA	1252

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HapMap Linkage Disequilibrium images for JMJD6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604914

1 Novoseek disease relationship for JMJD6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	38.84	2	11877474 (2)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/58 PubMed articles for JMJD6 gene (see all 58 ):

Phosphatidylserine receptor in chronic pancreatitis: evidence for a macrophage independent role. (PubMed id 15622002)^{1, 3, 4} Koeninger J.... Friess H. (2005)
Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. (PubMed id 15072554)^{1, 3, 4} Cao W.M.... Ishida T. (2004)
Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. (PubMed id 11877474)^{1, 2, 3} Vandivier R.W....Henson P.M. (2002)
JMJD6 is a histone arginine demethylase. (PubMed id 17947579)^{3, 4} Chang B.... Bruick R.K. (2007)
Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. (PubMed id 14729065)^{3, 4} Cui P.... Pei D. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{3, 4} Nagase T....Ohara O. (1998)
Phosphatidylserine receptor is required for the engulfment of dead apoptotic cells and for normal embryonic development in zebrafish. (PubMed id 15469976)^{1, 3} Hong J.R....Wu J.L. (2004)
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. (PubMed id 14645848)^{1, 3} Wang X....Xue D. (2003)
The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. (PubMed id 15193161)^{1, 3} Cikala M....Bottger A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23210	HGNC: 19355	AceView: PTDSR	Ensembl:ENSG00000070495	euGenes: HUgn23210
ECgene: JMJD6	H-InvDB: JMJD6

(According to HUGE)
About This Section

HUGE: KIAA0585

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for JMJD6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for JMJD6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JMJD6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JMJD6		Antibodies for JMJD6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for JMJD6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PTDSR)
	Antibodies (PTDSR)
	Chimera RNAi (PTDSR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	shRNA in GFP-retroviral vector

Search Tocris compounds for JMJD6

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JMJD6 Gene at Home site.
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JMJD6 Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for JMJD6

Summaries
for JMJD6

Genomic Location
for JMJD6

Proteins
for JMJD6

Protein Domains/
Families
for JMJD6

Gene Function
for JMJD6

Pathways & Interactions
for JMJD6

Drugs & Compounds
for JMJD6

Transcripts
for JMJD6

Expression
for JMJD6

Orthologs
for JMJD6

Paralogs
for JMJD6

SNPs/Variants
for JMJD6

Disorders & Mutations
for JMJD6

Medical News
for JMJD6

Publications
for JMJD6

Search for JMJD6

Genome Databases showing JMJD6

Other Databases showing JMJD6

Specialized Databases showing JMJD6

Licensable Technologies
for JMJD6

Services
for JMJD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JMJD6 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor JMJD6

Summariesfor JMJD6

Genomic Locationfor JMJD6

Proteinsfor JMJD6

Protein Domains/Familiesfor JMJD6

Gene Functionfor JMJD6

Pathways & Interactionsfor JMJD6

Drugs & Compoundsfor JMJD6

Transcriptsfor JMJD6

Expression for JMJD6

Orthologsfor JMJD6

Paralogsfor JMJD6

SNPs/Variantsfor JMJD6

Disorders & Mutationsfor JMJD6

Medical Newsfor JMJD6

Publicationsfor JMJD6

Search for JMJD6

Genome Databases showing JMJD6

Other Databases showing JMJD6

Specialized Databases showing JMJD6

Licensable Technologiesfor JMJD6

Servicesfor JMJD6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JMJD6

Summaries
for JMJD6

Genomic Location
for JMJD6

Proteins
for JMJD6

Protein Domains/
Families
for JMJD6

Gene Function
for JMJD6

Pathways & Interactions
for JMJD6

Drugs & Compounds
for JMJD6

Transcripts
for JMJD6

Expression
for JMJD6

Orthologs
for JMJD6

Paralogs
for JMJD6

SNPs/Variants
for JMJD6

Disorders & Mutations
for JMJD6

Medical News
for JMJD6

Publications
for JMJD6

Licensable Technologies
for JMJD6

Services
for JMJD6