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Aliases for JMJD4 Gene

Aliases for JMJD4 Gene

  • Jumonji Domain Containing 4 2 3
  • 2-Oxoglutarate- And Fe(II)-Dependent Oxygenase 2
  • Jumonji Domain-Containing Protein 4 4
  • C4 Lysyl Hydroxylase 2

External Ids for JMJD4 Gene

Previous GeneCards Identifiers for JMJD4 Gene

  • GC01M224226
  • GC01M225985
  • GC01M227918
  • GC01M198436

Summaries for JMJD4 Gene

GeneCards Summary for JMJD4 Gene

JMJD4 (Jumonji Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is JMJD6.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD4 Gene

Genomics for JMJD4 Gene

Regulatory Elements for JMJD4 Gene

Genomic Location for JMJD4 Gene

227,730,425 bp from pter
227,735,411 bp from pter
4,987 bases
Minus strand

Genomic View for JMJD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JMJD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD4 Gene

Proteins for JMJD4 Gene

  • Protein details for JMJD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    JmjC domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q5TBZ1
    • Q5TBZ6
    • Q9H970

    Protein attributes for JMJD4 Gene

    463 amino acids
    Molecular mass:
    52493 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14366.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23067.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for JMJD4 Gene


neXtProt entry for JMJD4 Gene

Proteomics data for JMJD4 Gene at MOPED

Post-translational modifications for JMJD4 Gene

  • Ubiquitination at Lys153 and Lys447
  • Modification sites at PhosphoSitePlus

Other Protein References for JMJD4 Gene

No data available for DME Specific Peptides for JMJD4 Gene

Domains for JMJD4 Gene

Protein Domains for JMJD4 Gene


Suggested Antigen Peptide Sequences for JMJD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 JmjC domain.
  • Contains 1 JmjC domain.
genes like me logo Genes that share domains with JMJD4: view

No data available for Gene Families for JMJD4 Gene

Function for JMJD4 Gene

Gene Ontology (GO) - Molecular Function for JMJD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24360279
genes like me logo Genes that share ontologies with JMJD4: view

Animal Model Products

miRNA for JMJD4 Gene

miRTarBase miRNAs that target JMJD4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JMJD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for JMJD4 Gene

Localization for JMJD4 Gene

Subcellular locations from

Jensen Localization Image for JMJD4 Gene COMPARTMENTS Subcellular localization image for JMJD4 gene
Compartment Confidence
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for JMJD4 Gene

Pathways for JMJD4 Gene

SuperPathways for JMJD4 Gene

No Data Available

Interacting Proteins for JMJD4 Gene

Gene Ontology (GO) - Biological Process for JMJD4 Gene


No data available for Pathways by source for JMJD4 Gene

Transcripts for JMJD4 Gene

Unigene Clusters for JMJD4 Gene

Jumonji domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JMJD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -

Relevant External Links for JMJD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JMJD4 Gene

mRNA expression in normal human tissues for JMJD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for JMJD4 Gene

This gene is overexpressed in Testis (48.8) and CD8 Tcells (20.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JMJD4 Gene

SOURCE GeneReport for Unigene cluster for JMJD4 Gene Hs.555974

genes like me logo Genes that share expressions with JMJD4: view

Expression partners for JMJD4 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JMJD4 Gene

Orthologs for JMJD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for JMJD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia JMJD4 35
  • 79.33 (n)
  • 76.92 (a)
JMJD4 36
  • 75 (a)
(Canis familiaris)
Mammalia JMJD4 35
  • 78.65 (n)
  • 78.26 (a)
JMJD4 36
  • 78 (a)
(Mus musculus)
Mammalia Jmjd4 35
  • 78.21 (n)
  • 76.44 (a)
Jmjd4 16
Jmjd4 36
  • 74 (a)
(Pan troglodytes)
Mammalia JMJD4 35
  • 99.28 (n)
  • 98.92 (a)
JMJD4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Jmjd4 35
  • 79.01 (n)
  • 77.88 (a)
(Monodelphis domestica)
Mammalia JMJD4 36
  • 58 (a)
(Gallus gallus)
Aves JMJD4 35
  • 64.81 (n)
  • 60.77 (a)
JMJD4 36
  • 59 (a)
(Anolis carolinensis)
Reptilia JMJD4 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia jmjd4 35
  • 62 (n)
  • 57.77 (a)
(Danio rerio)
Actinopterygii jmjd4 35
  • 61.1 (n)
  • 57.41 (a)
jmjd4 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008415 35
  • 53.66 (n)
  • 40.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7200 35
  • 50.38 (n)
  • 39.94 (a)
CG7200 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea jmjd-4 36
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63080 35
  • 46.49 (n)
  • 37.65 (a)
(Oryza sativa)
Liliopsida Os01g0546900 35
  • 48.14 (n)
  • 38.31 (a)
Species with no ortholog for JMJD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JMJD4 Gene

Gene Tree for JMJD4 (if available)
Gene Tree for JMJD4 (if available)

Paralogs for JMJD4 Gene

Paralogs for JMJD4 Gene Pseudogenes for JMJD4 Gene

genes like me logo Genes that share paralogs with JMJD4: view

Variants for JMJD4 Gene

Sequence variations from dbSNP and Humsavar for JMJD4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_032898 -
VAR_032899 -
VAR_032900 -
VAR_032901 -

Structural Variations from Database of Genomic Variants (DGV) for JMJD4 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv515496 CNV Loss 19592680
nsv873249 CNV Loss 21882294

Relevant External Links for JMJD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JMJD4 Gene

Disorders for JMJD4 Gene

No disorders were found for JMJD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for JMJD4 Gene

Publications for JMJD4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Optimal translational termination requires C4 lysyl hydroxylation of eRF1. (PMID: 24486019) Feng T. … Coleman M.L. (Mol. Cell 2014) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3

Products for JMJD4 Gene

Sources for JMJD4 Gene

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