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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

JMJD4 Gene

protein-coding GIFtS: 41
GCID: GC01M227918

jumonji domain containing 4

Search for JMJD4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Jumonji Domain Containing 4¹ ²
Jumonji Domain-Containing Protein 4² ³
FLJ12517¹
JmjC Domain-Containing Protein 4²

External Ids:	HGNC: 25724¹	Entrez Gene: 65094²	Ensembl: ENSG00000081692⁷	UniProtKB: Q9H9V9³

Export aliases for JMJD4 gene to outside databases

Previous GC identifers: GC01M224226 GC01M225985 GC01M198436

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167186.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the JMJD4 gene promoter:
AREB6 STAT1 AML1a POU2F1 POU2F1a LUN-1 CUTL1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JMJD4 promoter sequence

Search SABiosciences Chromatin IP Primers for JMJD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13

JMJD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD4 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M227918: view genomic region (about GC identifiers)

Start:	227,918,126 bp from pter	End:	227,923,112 bp from pter
Size:	4,987 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JMJD4_HUMAN, Q9H9V9 (See protein sequence)

Recommended Name: JmjC domain-containing protein 4

Size: 463 amino acids; 52493 Da

Caution: It is uncertain whether Met-1 or Met-47 is the initiator

Sequence caution: Sequence=BAB14366.1; Type=Erroneous initiation; Sequence=CAI23067.1; Type=Erroneous initiation;

Secondary accessions: Q5TBZ1 Q5TBZ6 Q9H970

Alternative splicing: 2 isoforms: Q9H9V9-1 Q9H9V9-2

Explore the universe of human proteins at neXtProt for JMJD4: NX_Q9H9V9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H9V9

JMJD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001154937.1 NP_075383.2

ENSEMBL proteins:

ENSP00000355720 ENSP00000387830

Human Recombinant Protein Products for JMJD4:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

JMJD4 for domains About GeneDecksing

1 InterPro domain/family:

IPR003347 JmjC_dom

Graphical View of Domain Structure for InterPro Entry Q9H9V9

ProtoNet protein and cluster: Q9H9V9

UniProtKB/Swiss-Prot: JMJD4_HUMAN, Q9H9V9

Similarity: Contains 1 JmjC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for JMJD4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): JMJD4 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for JMJD4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for JMJD4 (ENSP00000355720⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for JMJD4
Search CenterWatch for drugs/clinical trials and news about JMJD4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for JMJD4 gene (2 alternative transcripts):

NM_001161465.1 NM_023007.2

Unigene Clusters for JMJD4:

Jumonji domain containing 4

Hs.555974 [show with all ESTs], Hs.744163 [show with all ESTs]

Unigene Representative Sequences: AK026908, NM_023007

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000485807 ENST00000366758(uc001hrc.3 uc001hrb.3) ENST00000438896

ENST00000480590 ENST00000465251

miRNA Products:		OriGene 3'-UTR Clone (see all 2): JMJD4 Browse OriGene MicroRNA Expression Plasmids
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD4

Additional cDNA sequence:

AK022579.1 AK023030.1 BC011928.2 BC109272.2

24/27 DOTS entries (see all 27):

DT.95160318 DT.100834440 DT.100834442 DT.95160326 DT.95160338 DT.97847177 DT.101984021 DT.100756711

DT.100834424 DT.100834433 DT.40301445 DT.121447836 DT.100834445 DT.95160341 DT.121447654 DT.121447553

DT.121447672 DT.75152596 DT.100834444 DT.100649719 DT.100696655 DT.100834447 DT.100840419 DT.121447735

24/167 AceView cDNA sequences (see all 167):

BM559032 BQ436138 AI190926 CR593629 BE277284 AI623217 BM662512 CR603747

AI199369 BP873258 BI768068 BE908056 BE464071 BQ943765 BX482390 AI972516

CA433609 CD557198 AK026908 BE297279 BX444534 BM835213 BU683775 AW589974

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c
SP1:					-
SP2:					-								-
SP3:
SP4:

ECgene alternative splicing isoforms for JMJD4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

JMJD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAGTGCTT

About this image

JMJD4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See JMJD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JMJD4

SOURCE GeneReport for Unigene clusters: Hs.555974 Hs.744163

SABiosciences Custom PCR Arrays for JMJD4

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for JMJD4 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Jmjd4^{1 , 5}	jumonji domain containing 4^{1, 5}	78.21(n)¹ 76.44(a)¹		11 (37.71 cM)⁵ 194952¹ NM_178659.6¹ NP_848774.1¹ 59450045⁵
chicken (Gallus gallus)	Aves	JMJD4¹	jumonji domain containing 4	64.73(n) 60.77(a)		420400 NM_001030959.1 NP_001026130.1
lizard (Anolis carolinensis)	Reptilia	JMJD4⁶	--	57(a)	1 ↔ 1	GL343449.1(430572-440756)
zebrafish (Danio rerio)	Actinopterygii	CK401100.1²	--	70.76(n)		CK401100.1
fruit fly (Drosophila melanogaster)	Insecta	CG7200¹	CG7200	54.03(n) 43.62(a)		35089 NM_136026.3 NP_609870.1
worm (Caenorhabditis elegans)	Secernentea	jmjd-4⁶	--	29(a)	1 ↔ 1	III(10332361-10333975)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G63080⁶	transcription factor jumonji (jmjC) domain-contain...	26(a)	1 ↔ 1	5(25299935-25302444)
rice (Oryza sativa)	Liliopsida	--	jmjC domain-containing protein 4, putative, expres...	27(a)	1 ↔ 1	1(20321653-20325331)

ENSEMBL Gene Tree for JMJD4 (if available)
TreeFam Gene Tree for JMJD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for JMJD4 gene

JMJD6²

JMJD4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for JMJD4
PGOHUM00000238177

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73093304^1,2	C	--	227918420(+)	`AGGAGC/TGCAGG`	4	--	int¹		2		WA	120
rs141603297^1,2		--	227918483(+)	`AGTTCC/GCACTG`	4	--	int¹		0	--	--	--	--
rs6664307^1,2	C,F,A,H	--	227918562(+)	`AGCTGC/TCTGCT`	4	--	int¹		16		NS EA WA NA CSA	1056
rs187582969^1,2		--	227918876(+)	`ATACAA/GGTCCC`	4	--	int¹		0	--	--	--	--
rs143726691^1,2	C	--	227918879(+)	`CAGGT-/CCCTGG`	4	--	int¹		0	--	--	--	--
rs76269517^1,2	F	--	227918976(+)	`TTCACT/CGAACA`	4	--	ut3¹ int¹		1		EA	120
rs192053971^1,2		--	227919038(+)	`CCAGCA/GGCCCC`	4	--	int¹ ut3¹		0	--	--	--	--
rs146043836^1,2		--	227919089(+)	`GTGCCA/GTCCCT`	4	--	int¹ ut3¹		0	--	--	--	--
rs77870786^1,2	C,F	--	227919102(+)	`GGATTC/TGGATG`	4	--	int¹ ut3¹		1		WA	118
rs184188722^1,2		--	227919121(+)	`CCTGCA/TGGGGT`	4	--	int¹ ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for JMJD4 (227918126 - 227923112 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for JMJD4
6 CNVs: 48261 48262 48258 6812 48260 48259

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD4

DNA2.0 Custom Variant and Variant Library Synthesis for JMJD4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for JMJD4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with JMJD4)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)¹ Lango Allen H....Hirschhorn J.N. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 65094	HGNC: 25724	AceView: FLJ12517	Ensembl:ENSG00000081692	euGenes: HUgn65094
ECgene: JMJD4	H-InvDB: JMJD4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for JMJD4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for JMJD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for JMJD4 gene:
Search GeneIP for patents involving JMJD4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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	OriGene Antibodies for JMJD4		OriGene shRNA RFP for JMJD4
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JMJD4
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	GenScript Custom Purified and Recombinant Proteins Services for JMJD4		GenScript cDNA clones with any tag delivered in your preferred vector for JMJD4
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD4

	SwitchGear 3'UTR luciferase reporter plasmids for JMJD4
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ThermoFisher Antibodies for JMJD4

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inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for JMJD4

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes JMJD4 gene at Home site.

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JMJD4 Gene

jumonji domain containing 4

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Export list of displayed genes

JMJD4 Gene

jumonji domain containing 4

Aliasesfor JMJD4 gene

Summariesfor JMJD4 gene

Genomic Viewsfor JMJD4 gene

Proteinsfor JMJD4 gene

Protein Domains /Familiesfor JMJD4 gene

Functionfor JMJD4 gene

Pathways & Interactionsfor JMJD4 gene

Drugs & Compoundsfor JMJD4 gene

Transcriptsfor JMJD4 gene

Expression for JMJD4 gene

Orthologsfor JMJD4 gene

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External Searches for JMJD4 gene

Genome Databases showing JMJD4 gene

Other Databases showing JMJD4 gene

Specialized Databases showing JMJD4 gene

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Aliases
for JMJD4 gene

Summaries
for JMJD4 gene

Genomic Views
for JMJD4 gene

Proteins
for JMJD4 gene

Protein Domains /
Families
for JMJD4 gene

Function
for JMJD4 gene

Pathways & Interactions
for JMJD4 gene

Drugs & Compounds
for JMJD4 gene

Transcripts
for JMJD4 gene

Expression
for JMJD4 gene

Orthologs
for JMJD4 gene

Paralogs
for JMJD4 gene

Genomic Variants
for JMJD4 gene

Disorders / Diseases
for JMJD4 gene

Publications
for JMJD4 gene

Intellectual Property
for JMJD4 gene

Products
for JMJD4 gene