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KDM4C Gene

protein-coding GIFtS: 50

GC09P006747

lysine (K)-specific demethylase 4C
(Previous name: jumonji domain containing 2C )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: JMJD2C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.11.- ^³
FLJ25949 ^²
GASC1 ^¹, ², ³
JHDM3C ^², ³
JMJD2C ^², ³
KIAA0780 ^¹, ², ³
OTTHUMP00000021052 ^²
OTTHUMP00000044461 ^²
bA146B14.1 ^²

Descriptions
GASC-1 protein ^³
Gene amplified in squamous cell carcinoma 1 protein ^³
JmjC domain-containing histone demethylation protein 3C ^², ³
Jumonji domain-containing protein 2C ^³
gene amplified in squamous cell carcinoma 1 ^²
jumonji domain containing 2C ^¹, ²
lysine (K)-specific demethylase 4C ^²
lysine-specific demethylase 4C ^¹

External Ids
HGNC: 17071¹
Entrez Gene: 23081²
UniProtKB: Q9H3R0³
Ensembl: ENSG00000107077⁷

Search outside databases for aliases for KDM4C gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KDM4C:

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC

domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein

functions as a trimethylation-specific demethylase, converting specific trimethylated histone

residues to the dimethylated form. Chromosomal aberrations and increased transcriptional

expression of this gene are associated with esophageal squamous cell carcinoma. Alternative

splicing results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: KDM4C_HUMAN, Q9H3R0

Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of

histone H3, thereby playing a central role in histone code. Does not demethylate histone H3

'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36'

residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue

generates formaldehyde and succinate

Gene Wiki entry for KDM4C (JMJD2C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1 Ensembl cytogenetic band: 9p24.1 HGNC cytogenetic band: 9p24-p23

KDM4C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P006747: (about GC identifiers)

Start:	6,747,654 bp from pter
End:	7,165,648 bp from pter
Size:	417,995 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KDM4C_HUMAN, Q9H3R0 (See protein sequence)

Recommended Name: Lysine-specific demethylase 4C

Size: 1056 amino acids; 119982 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=CAI39533.1; Type=Erroneous gene model prediction; Sequence=CAI39608.1;

Type=Erroneous gene model prediction;

Secondary accessions: O94877 Q2M3M0 Q5JUC9 Q5VYJ2 Q5VYJ3

Alternative splicing: 2 isoforms: Q9H3R0-1 Q9H3R0-2

REFSEQ proteins (4 alternative transcripts):

NP_001140166.1 NP_001140167.1 NP_001140168.1 NP_055876.2

ENSEMBL proteins:

ENSP00000370707 ENSP00000383990 ENSP00000370710

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KDM4C / GASC1 / JMJD2C)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005634	nucleus	IEA	--

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Antibodies for KDM4C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KDM4C / GASC1 / JMJD2C), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JMJD2C)
	Novus Biologicals Antibody for JMJD2C

Assays for KDM4C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9H3R0

ProtoNet protein and cluster: Q9H3R0

3 Blocks protein families:

IPB002999 Tudor domain

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM4C_HUMAN, Q9H3R0

Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an

interdigitated structure and the unusual fold is required for its ability to bind methylated

histone tails (By similarity)

Similarity: Belongs to the JHDM3 histone demethylase family

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

Similarity: Contains 2 Tudor domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015061

Applied Biosystems Silencer® siRNAs for KDM4C

Sigma-Aldrich siRNA and siRNA Panels for KDM4C

Sigma-Aldrich shRNA for KDM4C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015061
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015061
untagged cDNA clone in CMV expression vector: NM_015061

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015061

UniProtKB/Swiss-Prot: KDM4C_HUMAN, Q9H3R0

Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of

histone H3, thereby playing a central role in histone code. Does not demethylate histone H3

'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36'

residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue

generates formaldehyde and succinate

Enzyme Number (IUBMB): EC 1.14.11.-

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KDM4C

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--
GO:0016568	chromatin modification	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KDM4C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2C)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015061

Sigma-Aldrich siRNA and siRNA Panels for KDM4C

Sigma-Aldrich shRNA for KDM4C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015061

REFSEQ mRNAs for KDM4C gene (4 alternative transcripts):

NM_001146694.1 NM_001146695.1 NM_001146696.1 NM_015061.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015061

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015061
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015061
                                 untagged cDNA clone in CMV expression vector: NM_015061

Additional cDNA sequence:

AB018323.1 AB037901.1 AK098534.1 AK296401.1 AK303651.1 AK304032.1 AK304095.1 AK310439.1

AK314355.1 BC008296.1 BC036628.2 BC042976.2 BC053678.1 BC060771.1 BC104859.1 BC104861.1

BC143571.1 CR600819.1

24/29 DOTS entries (see all 29 ):

DT.99981759 DT.100823066 DT.100823065 DT.91768275 DT.75169436 DT.91768266 DT.107530 DT.306886

DT.100823069 DT.100823071 DT.40126457 DT.100024027 DT.101958301 DT.75135105 DT.99930232 DT.121146794

DT.86846917 DT.91768262 DT.305092 DT.75105207 DT.75141359 DT.75181324 DT.100024026 DT.433347

24/247 AceView cDNA sequences (see all 247 ):

BE265181 BU660755 BC008296 BM456170 CR600819 AB018323 AI341811 AI923971

AA719275 CD368911 BU079145 BG203616 AA465547 CA952644 AJ278544 BX330147

R25177 BQ694638 AW835673 BG207259 BC053678 BG181379 BG191276 AV645419

Unigene Cluster for KDM4C:

Lysine (K)-specific demethylase 4C

Hs.709425 [show with all ESTs]

Unigene Representative Sequence: NM_015061

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000381306 ENST00000401787 ENST00000381309

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KDM4C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDM4C

¹ / ²

11 probe-sets matching KDM4C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
76254_at²	U95-E	1	1.00	1.00	0.51	1.25	--	--	--	--	--
57978_at²	U95-B	1	1.00	1.00	0.42	0.34	--	--	--	--	--
34979_at²	U95-A	1	1.00	1.00	0.45	0.12	--	--	--	--	--
69042_at²	U95-D	1	1.00	1.00	0.64	0.60	--	--	--	--	--
60153_at²	U95-C	1	1.00	1.00	0.51	1.19	--	--	--	--	--
79538_f_at²	U95-E	1	0.81	1.00	0.33	1.01	--	--	--	--	--
209984_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
214861_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
209984_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1556493_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214861_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KDM4C for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATTTTTCTTT

SOURCE GeneReport for Unigene cluster: Hs.709425
UniProtKB/Swiss-Prot: KDM4C_HUMAN, Q9H3R0
Tissue specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KDM4C gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JMJD2C¹	--	jumonji domain containing 2C	89.65(n) 90.12(a)	474704 XM_531930.2 XP_531930.2
chimpanzee (Pan troglodytes)	JMJD2C¹	--	jumonji domain containing 2C	99.08(n) 99.34(a)	464989 XM_001144352.1 XP_001144352.1
rat (Rattus norvegicus)	Jmjd2c¹	--	jumonji domain containing 2C	83.41(n) 83.75(a)	298144 XM_216426.4 XP_216426.4
mouse (Mus musculus)	Kdm4c⁵ Jmjd2c¹	4⁵	lysine (K)-specific demethylase 4C⁵ jumonji domain containing 2C¹	84.09(n)¹ 84.72(a)¹	76804¹ NM_144787.1¹ NP_659036.1¹ AA517467⁵ AI118679⁵ (see all 18)
baker's yeast (Saccharomyces cerevisiae)	RPH1(YER169W)⁴	5(523364-525754)	JmjC domain-containing histone demethylase which can more	--	856916 NP_011096.1

About this table Species with no ortholog for KDM4C

ENSEMBL Gene Tree for KDM4C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KDM4C gene

KDM4D² KDM4A² JARID2² KDM4B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2890 NCBI SNPs in KDM4C are shown (see all 2890 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1205)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs913590^1,2	A,C,F,H,O	7164898(+)	`TACACA/CCAATG`	1	--	ut3¹ ese³		12	MN NA EU EA WA	1162
	rs913588^1,2	A,C,F,H,O	7164673(+)	`ACCCTG/ATATAC`	1	I/V	mis¹ ese³		25	NA EA MN EU WA	2276
	rs913589^1,2	A,C,F,H,O	7164773(+)	`TGGAAA/GAGAGA`	1	--	ut3¹ trp³		20	NA EA MN EU WA	3248
	rs943925^1,2	A,C,F,H	7165689(+)	`AACCAA/GTAGAA`	1	--	ng3¹		4	EU EA WA	354
	rs7045956^1,2	A,C,F,H	7165734(+)	`TACTGC/TGGCCC`	1	--	ng3¹		5	NA EU WA	374
	rs4742259^1,2	A,C,F,H	6745968(+)	`AGGTTC/AGTATA`	1	--	ng5¹		8	EU EA WA	838
	rs4742260^1,2	A,C,F,H	6747031(+)	`CTCTGT/CAGGAA`	1	--	ng5¹		4	EU EA WA	416
	rs2820934^1,2	A,C,F,H	7166125(-)	`GCTTTC/TTGCTG`	1	--	ng3¹		4	EU EA WA	410
	rs2296067^1,2	C,F,H,O	6974236(+)	`AAGTCA/GATGGG`	1	D/N	mis¹		14	EA NA EU WA	2618
	rs1417290^1,2	A,C,F,H	7036917(+)	`CAATAA/GGTAAG`	1	K/R	mis¹		17	NS NA EU EA WA	1166

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HapMap Linkage Disequilibrium images for KDM4C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605469

2 Novoseek disease relationships for KDM4C gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma squamous cell	42.05	7	16732293 (2), 15138608 (1), 11346465 (1)
cancer	0.00	1	16732293 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/17 PubMed articles for KDM4C gene (see all 17 ):

Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{2, 3, 4} Nagase T....Ohara O. (1998)
Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)^{1, 2, 3} Katoh M. and Katoh M. (2004)
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)^{3, 4} Whetstine J.R.... Shi Y. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines. (PubMed id 10987278)^{3, 4} Yang Z.Q.... Inazawa J. (2000)
Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. (PubMed id 17611647)^{1, 3} Katoh Y. and Katoh M. (2007)
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. (PubMed id 17277772)^{1, 3} Wissmann M....Schule R. (2007)
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. (PubMed id 16732293)^{1, 3} Cloos P.A....Helin K. (2006)
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)³ Canova C....Brennan P. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23081	HGNC: 17071	AceView: JMJD2C	Ensembl:ENSG00000107077	euGenes: HUgn23081
ECgene: KDM4C	H-InvDB: KDM4C

(According to HUGE)
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HUGE: KIAA0780

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KDM4C	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KDM4C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KDM4C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDM4C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDM4C		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KDM4C		Browse small molecules at Sigma-Aldrich
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KDM4C Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for KDM4C

Summaries
for KDM4C

Genomic Location
for KDM4C

Proteins
for KDM4C

Protein Domains/
Families
for KDM4C

Gene Function
for KDM4C

Pathways & Interactions
for KDM4C

Drugs & Compounds
for KDM4C

Transcripts
for KDM4C

Expression
for KDM4C

Orthologs
for KDM4C

Paralogs
for KDM4C

SNPs/Variants
for KDM4C

Disorders & Mutations
for KDM4C

Medical News
for KDM4C

Publications
for KDM4C

Search for KDM4C

Genome Databases showing KDM4C

Other Databases showing KDM4C

Specialized Databases showing KDM4C

Licensable Technologies
for KDM4C

Services
for KDM4C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDM4C Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor KDM4C

Summariesfor KDM4C

Genomic Locationfor KDM4C

Proteinsfor KDM4C

Protein Domains/Familiesfor KDM4C

Gene Functionfor KDM4C

Pathways & Interactionsfor KDM4C

Drugs & Compoundsfor KDM4C

Transcriptsfor KDM4C

Expression for KDM4C

Orthologsfor KDM4C

Paralogsfor KDM4C

SNPs/Variantsfor KDM4C

Disorders & Mutationsfor KDM4C

Medical Newsfor KDM4C

Publicationsfor KDM4C

Search for KDM4C

Genome Databases showing KDM4C

Other Databases showing KDM4C

Specialized Databases showing KDM4C

Licensable Technologiesfor KDM4C

Servicesfor KDM4C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDM4C

Summaries
for KDM4C

Genomic Location
for KDM4C

Proteins
for KDM4C

Protein Domains/
Families
for KDM4C

Gene Function
for KDM4C

Pathways & Interactions
for KDM4C

Drugs & Compounds
for KDM4C

Transcripts
for KDM4C

Expression
for KDM4C

Orthologs
for KDM4C

Paralogs
for KDM4C

SNPs/Variants
for KDM4C

Disorders & Mutations
for KDM4C

Medical News
for KDM4C

Publications
for KDM4C

Licensable Technologies
for KDM4C

Services
for KDM4C