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KDM4B Gene

protein-coding GIFtS: 54

GC19P004921

lysine (K)-specific demethylase 4B
(Previous name: jumonji domain containing 2B )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: JMJD2B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.11.- ^³
FLJ44906 ^²
JHDM3B ^³
JMJD2B ^², ³
KIAA0876 ^¹, ², ³

Descriptions
JmjC domain-containing histone demethylation protein 3B ^³
Jumonji domain-containing protein 2B ^³
jumonji domain containing 2B ^¹, ²
lysine (K)-specific demethylase 4B ^²
lysine-specific demethylase 4B ^¹

External Ids
HGNC: 29136¹
Entrez Gene: 23030²
UniProtKB: O94953³
Ensembl: ENSG00000127663⁷

Search outside databases for aliases for KDM4B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing

a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4

'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A,

KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate

Gene Wiki entry for KDM4B (JMJD2B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

KDM4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P004921: (about GC identifiers)

Start:	4,920,132 bp from pter
End:	5,104,606 bp from pter
Size:	184,475 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953 (See protein sequence)

Recommended Name: Lysine-specific demethylase 4B

Size: 1096 amino acids; 121897 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subcellular location: Nucleus

Sequence caution: Sequence=AAC33799.1; Type=Erroneous gene model prediction;

Secondary accessions: O75274 Q6P3R5 Q9P1V1 Q9UF40

Alternative splicing: 2 isoforms: O94953-1 O94953-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055830.1

ENSEMBL proteins:

ENSP00000371178 ENSP00000159111

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KDM4B / JMJD2B)
	Human Recombinant Proteins from Abnova (JMJD2B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for KDM4B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KDM4B (JMJD2B)
	Antibodies from Abcam (KDM4B / JMJD2B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JMJD2B)
	Novus Biologicals Antibodies for JMJD2B

Assays for KDM4B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O94953

ProtoNet protein and cluster: O94953

3 Blocks protein families:

IPB001965 Zn-finger-like

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an

interdigitated structure and the unusual fold is required for its ability to bind methylated

histone tails (By similarity)

Similarity: Belongs to the JHDM3 histone demethylase family

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

Similarity: Contains 2 Tudor domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015015

Applied Biosystems Silencer® siRNAs for KDM4B

Sigma-Aldrich siRNA and siRNA Panels for KDM4B

Sigma-Aldrich shRNA for KDM4B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for KDM4B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015015
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015015
untagged cDNA clone in CMV expression vector: NM_015015

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015015

UniProtKB/Swiss-Prot: KDM4B_HUMAN, O94953

Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing

a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4

'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A,

KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate

Enzyme Number (IUBMB): EC 1.14.11.-

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5 Interacting proteins for KDM4B (ENSP00000159111³ O94953²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED10	Q9BTT4²	MINT-65334
JMJD1C	ENSP00000335929³	STRING (score=.953)
PDC	ENSP00000342033³	STRING (score=.895)
MBD2	ENSP00000256429³	STRING (score=.803)
--	ENSP00000349194³	STRING (score=.728)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KDM4B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015015

Sigma-Aldrich siRNA and siRNA Panels for KDM4B

Sigma-Aldrich shRNA for KDM4B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015015

REFSEQ mRNAs for KDM4B gene:

NM_015015.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015015

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015015
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015015
                                 untagged cDNA clone in CMV expression vector: NM_015015

Additional cDNA sequence:

AB020683.2 AF052144.1 AK026040.1 AK090405.1 AK126854.1 AL133622.1 AL831872.1 BC015378.1

BC040014.1 BC046167.1 BC063889.1 BC136611.1 BC144292.1 CR592462.1

14 DOTS entries:

DT.95268131 DT.100673094 DT.91736535 DT.100782044 DT.75166336 DT.97842572 DT.99929060 DT.91736528

DT.91894949 DT.100025963 DT.92010446 DT.101967033 DT.121459830 DT.97798143

24/63 AceView cDNA sequences (see all 63 ):

BC063889 BM992894 BQ219578 BF868628 AW450344 AA884638 CB158429 AL831872

BM801857 AI939571 BG236071 BU844833 CA307451 AI658783 AI362737 BI020470

BE672463 AA326284 AI684636 BM703561 BF313933 BE261870 BQ225977 BM703553

Unigene Cluster for KDM4B:

Lysine (K)-specific demethylase 4B

Hs.654816 [show with all ESTs]

Unigene Representative Sequence: NM_015015

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for KDM4B (see all 13 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	·
SP1:			-		-										-				-								-
SP2:
SP3:
SP4:																											-										-		-		-
SP5:

ExUns:	21c	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26	^	27	^	28a	·	28b	^	29	^	30	^	31a	·	31b	^	32
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KDM4B

2 Ensembl transcripts including schematic representations:

ENST00000381759 ENST00000159111

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KDM4B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDM4B

¹ / ²

13 probe-sets matching KDM4B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33226_at²	U95-A	1	1.00	1.00	0.87	0.83	--	--	--	--	--
58501_at²	U95-B	1	0.88	1.00	0.79	1.49	--	--	--	--	--
68886_r_at*²	U95-D	1	0.81	1.00	0.89	0.69	--	--	--	--	--
216023_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
215616_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212492_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212495_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
212496_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
216023_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215616_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212492_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212495_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212496_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KDM4B for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACGCTGCGA

SOURCE GeneReport for Unigene cluster: Hs.654816

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KDM4B gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JMJD2B¹	--	jumonji domain containing 2B	87.15(n) 89.42(a)	476741 XM_533946.2 XP_533946.2
chimpanzee (Pan troglodytes)	JMJD2B¹	--	jumonji domain containing 2B	99.3(n) 99.45(a)	455614 XM_001140426.1 XP_001140426.1
cow (Bos taurus)	JMJD2B¹	--	jumonji domain containing 2B	86.57(n) 89.32(a)	508141 XM_584880.3 XP_584880.3
mouse (Mus musculus)	Kdm4b⁵ Jmjd2b¹	17⁵	lysine (K)-specific demethylase 4B⁵ jumonji domain containing 2B¹	80.87(n)¹ 83.71(a)¹	193796¹ NM_172132.1¹ NP_742144.1¹ AK028962⁵ AK043678⁵ (see all 22)
zebrafish (Danio rerio)	si:ch211-124a3.4¹	--	si:ch211-124a3.4	65.19(n) 62.24(a)	556504 NM_001082805.1 NP_001076274.1

About this table Species with no ortholog for KDM4B

ENSEMBL Gene Tree for KDM4B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KDM4B gene

KDM4D² KDM4A² JARID2² KDM4C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1160 NCBI SNPs in KDM4B are shown (see all 1160 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 336)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2613804^1,2	A,C,F,H	5103445(+)	`CCTCCC/TATGGC`	1	--	ut3¹ ese³		4		EU EA WA	404
--	rs11514^1,2	A,C,F,H	5104606(-)	`GGTTTC/TGCAGC`	1	--	ut3¹		6		EA MN EU WA	2082
--	rs6510832^1,2	A,C,F,H	4918954(+)	`TAAGCT/GCCAGA`	1	--	ng5¹ tfbs³		3		EU EA	300
	rs2620828^1,2	A,C,F,H	5103387(-)	`CTCTCG/AGGTGA`	1	--	ut3¹ ese³		4		EU EA WA	406
	rs197147^1,2	C,F,H	4918407(-)	`AAACCG/AGTATC`	1	--	ng5¹		5		MN EU EA WA	602
	rs2620827^1,2	A,C	5104793(-)	`AGCTGC/TCCCTG`	1	--	ng3¹		0	--	--	--	--
	rs197146^1,2	C	4918946(-)	`TTACAC/TAATTC`	1	--	ng5¹		1		MN	184
	rs11667206^1,2	H	4983987(+)	`CTTCAA/CCAAAT`	1	N/T	mis¹ ese³		4		EU EA WA	406
--	rs10689^1,2	F	5104604(-)	`TTTCGC/TAGCGT`	1	--	ut3¹ ese³		1		MN	184
	rs2620836^1,2	C	5086392(-)	`GCCCTC/TTCCGA`	1	E/K	mis¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for KDM4B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609765

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/17 PubMed articles for KDM4B gene (see all 17 ):

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)^{2, 3, 4} Nagase T....Ohara O. (1998)
Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)^{1, 2, 3} Katoh M. and Katoh M. (2004)
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)^{1, 3, 4} Gray S.G.... Dangond F. (2005)
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)^{3, 4} Whetstine J.R.... Shi Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. (PubMed id 17611647)^{1, 3} Katoh Y. and Katoh M. (2007)
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. (PubMed id 18713068)³ Pollard P.J....Ratcliffe P.J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23030	HGNC: 29136	AceView: JMJD2B	Ensembl:ENSG00000127663	euGenes: HUgn23030
ECgene: KDM4B	H-InvDB: KDM4B

(According to HUGE)
About This Section

HUGE: KIAA0876

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KDM4B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KDM4B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDM4B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDM4B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KDM4B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for KDM4B (JMJD2B)

	Recombinant Proteins (KDM4B / JMJD2B)
	Antibodies (KDM4B / JMJD2B)

Search OriGene for KDM4B

Search Tocris compounds for KDM4B

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for JMJD2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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KDM4B Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for KDM4B

Summaries
for KDM4B

Genomic Location
for KDM4B

Proteins
for KDM4B

Protein Domains/
Families
for KDM4B

Gene Function
for KDM4B

Pathways & Interactions
for KDM4B

Drugs & Compounds
for KDM4B

Transcripts
for KDM4B

Expression
for KDM4B

Orthologs
for KDM4B

Paralogs
for KDM4B

SNPs/Variants
for KDM4B

Disorders & Mutations
for KDM4B

Medical News
for KDM4B

Publications
for KDM4B

Search for KDM4B

Genome Databases showing KDM4B

Other Databases showing KDM4B

Specialized Databases showing KDM4B

Licensable Technologies
for KDM4B

Services
for KDM4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDM4B Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor KDM4B

Summariesfor KDM4B

Genomic Locationfor KDM4B

Proteinsfor KDM4B

Protein Domains/Familiesfor KDM4B

Gene Functionfor KDM4B

Pathways & Interactionsfor KDM4B

Drugs & Compoundsfor KDM4B

Transcriptsfor KDM4B

Expression for KDM4B

Orthologsfor KDM4B

Paralogsfor KDM4B

SNPs/Variantsfor KDM4B

Disorders & Mutationsfor KDM4B

Medical Newsfor KDM4B

Publicationsfor KDM4B

Search for KDM4B

Genome Databases showing KDM4B

Other Databases showing KDM4B

Specialized Databases showing KDM4B

Licensable Technologiesfor KDM4B

Servicesfor KDM4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDM4B

Summaries
for KDM4B

Genomic Location
for KDM4B

Proteins
for KDM4B

Protein Domains/
Families
for KDM4B

Gene Function
for KDM4B

Pathways & Interactions
for KDM4B

Drugs & Compounds
for KDM4B

Transcripts
for KDM4B

Expression
for KDM4B

Orthologs
for KDM4B

Paralogs
for KDM4B

SNPs/Variants
for KDM4B

Disorders & Mutations
for KDM4B

Medical News
for KDM4B

Publications
for KDM4B

Licensable Technologies
for KDM4B

Services
for KDM4B