V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

KDM4A Gene

protein-coding GIFtS: 54

GC01P043889

lysine (K)-specific demethylase 4A
(Previous names: jumonji domain containing 2, jumonji domain containing 2A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: JMJD2, JMJD2A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.11.- ^³
JHDM3A ^¹, ², ³
JMJD2 ^², ³
JMJD2A ^², ³
KIAA0677 ^¹, ², ³
OTTHUMP00000008810 ^²

Descriptions
JmjC domain-containing histone demethylation protein 3A ^³
Jumonji domain-containing protein 2A ^³
jumonji C domain-containing histone demethylase 3A ^²
jumonji domain containing 2 ^¹, ²
jumonji domain containing 2A ^¹, ²
lysine (K)-specific demethylase 4A ^²
lysine-specific demethylase 4A ^¹

External Ids
HGNC: 22978¹
Entrez Gene: 9682²
UniProtKB: O75164³
Ensembl: ENSG00000066135⁷

Search outside databases for aliases for KDM4A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KDM4A:

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a

JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This

nuclear protein functions as a trimethylation-specific demethylase, converting specific

trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

[provided by RefSeq]

UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164

Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of

histone H3, thereby playing a central role in histone code. Does not demethylate histone H3

'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36'

residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue

generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and

E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively

Gene Wiki entry for KDM4A (JMJD2A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.1

KDM4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P043889: (about GC identifiers)

Start:	43,888,384 bp from pter
End:	43,943,776 bp from pter
Size:	55,393 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164 (See protein sequence)

Recommended Name: Lysine-specific demethylase 4A

Size: 1064 amino acids; 120720 Da

Cofactor: Binds 1 Fe(2+) ion per subunit

Subunit: Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and

NCOR1. Interacts with HTLV-1 Tax protein

Subcellular location: Nucleus

PDB structures from and Proteopedia :

2GF7 (3D)

2GFA (3D)

2GP3 (3D)

2GP5 (3D)

2OQ6 (3D)

2OQ7 (3D)

2OS2 (3D)

2OT7 (3D)

2OX0 (3D)

2P5B (3D)

2PXJ (3D)

2Q8C (3D)

2Q8D (3D)

2Q8E (3D)

2QQR (3D)

2QQS (3D)

2VD7 (3D)

Secondary accessions: Q5VVB1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055478.2

ENSEMBL proteins:

ENSP00000361473

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KDM4A / JHDM3A / JMJD2A)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16024779
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

About this table

Antibodies for KDM4A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KDM4A
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for KDM4A (JMJD2A)
	Antibodies from Abcam (KDM4A / JHDM3A / JMJD2A), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for JMJD2A

Assays for KDM4A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O75164

ProtoNet protein and cluster: O75164

2 Blocks protein families:

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164

Domain: The 2 Tudor domains recognize and bind methylated histone H3 'Lys-4' residue. Double Tudor

domain has an interdigitated structure and the unusual fold is required for its ability to bind

methylated histone tails. Trimethylated H3 'Lys-4' is bound in a cage of 3 aromatic residues, 2 of

which are from the Tudor domain 2, while the binding specificity is determined by side-chain

interactions involving residues from the Tudor domain 1. The Tudor domains are able to bind

trimethylated histone H3 'Lys-4', trimethylated histone H3 'Lys-9', di- and trimethylated H4

'Lys-20'

Similarity: Belongs to the JHDM3 histone demethylase family

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

Similarity: Contains 2 Tudor domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014663

Applied Biosystems Silencer® siRNAs for KDM4A

Sigma-Aldrich siRNA and siRNA Panels for KDM4A

Sigma-Aldrich shRNA for KDM4A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014663
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014663
untagged cDNA clone in CMV expression vector: NM_014663

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014663

UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164

Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of

histone H3, thereby playing a central role in histone code. Does not demethylate histone H3

'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36'

residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue

generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and

E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively

Enzyme Number (IUBMB): EC 1.14.11.-

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	17567753
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KDM4A

5/34 Interacting proteins for KDM4A (O75164^{1, 2} ENSP00000361473³) via UniProtKB, MINT, and/or STRING (see all 34 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3J	P68431², ENSP00000352252³	MINT-2829722 MINT-2830454 MINT-2830478 MINT-2830611 MINT-2829672 MINT-2829698 MINT-2829063 STRING (score=.867)
HIST3H3	Q16695¹	EBI-936709, EBI-358900
HIST1H3A	P68431²	MINT-2829722 MINT-2830454 MINT-2830478 MINT-2830611 MINT-2829672 MINT-2829698 MINT-2829063
HIST1H3B	P68431²	MINT-2829722 MINT-2830454 MINT-2830478 MINT-2830611 MINT-2829672 MINT-2829698 MINT-2829063
HIST1H3C	P68431²	MINT-2829722 MINT-2830454 MINT-2830478 MINT-2830611 MINT-2829672 MINT-2829698 MINT-2829063

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	IEA	--
GO:0016577	histone demethylation	IDA	16024779
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KDM4A
1 Novoseek chemical compound relationship for KDM4A gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	36.62	1	16603238 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM4A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD2A)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014663

Sigma-Aldrich siRNA and siRNA Panels for KDM4A

Sigma-Aldrich shRNA for KDM4A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014663

REFSEQ mRNAs for KDM4A gene:

NM_014663.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014663

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014663
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014663
                                 untagged cDNA clone in CMV expression vector: NM_014663

Additional cDNA sequence:

AB014577.1 AK294596.1 AK300039.1 AK310295.1 BC002558.2 CR596058.1

10 DOTS entries:

DT.415303 DT.91975395 DT.86854217 DT.95338656 DT.97811185 DT.100000158 DT.92024385 DT.95329546

DT.97815843 DT.97843731

24/147 AceView cDNA sequences (see all 147 ):

AA505063 BU543629 T60254 AI623088 BM459303 BG035010 BQ440865 AA481235

BQ229739 AI202395 AI263358 CA488018 AA505761 AI384099 BM826345 AI185891

BE252880 NM_014663 CD724275 AA481160 Z70219 BQ216769 BX471167 BP357225

Unigene Cluster for KDM4A:

Lysine (K)-specific demethylase 4A

Hs.155983 [show with all ESTs]

Unigene Representative Sequence: NM_014663

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for KDM4A (see all 8 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18a	·	18b	^	19	^	20	^	21	^
SP1:			-		-		-		-				-																								-
SP2:													-
SP3:
SP4:									-				-
SP5:									-

ExUns:	22a	·	22b	^	23a	·	23b	·	23c	^	24a	·	24b
SP1:	-				-				-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KDM4A

1 Ensembl transcript including schematic representation:

ENST00000372396

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

KDM4A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDM4A

¹ / ²

5 probe-sets matching KDM4A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32073_at²	U95-A	1	1.00	1.00	1.00	1.00	--	--	--	--	--
203205_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203204_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203205_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203204_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KDM4A for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CAGGGGCTGG

SOURCE GeneReport for Unigene cluster: Hs.155983
UniProtKB/Swiss-Prot: KDM4A_HUMAN, O75164
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KDM4A gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JMJD2A¹	--	jumonji domain containing 2A	92.1(n) 96.43(a)	482530 XM_845912.1 XP_851005.1
chimpanzee (Pan troglodytes)	JMJD2A¹	--	jumonji domain containing 2A	96.39(n) 95.77(a)	456829 XM_513384.2 XP_513384.2
cow (Bos taurus)	JMJD2A¹	--	similar to JmjC domain-containing histone demethylation more	90.22(n) 95.86(a)	512622 XM_879774.2 XP_884867.2
rat (Rattus norvegicus)	Jmjd2a¹	--	jumonji domain containing 2A	87.54(n) 93.5(a)	313539 XM_233441.4 XP_233441.4
mouse (Mus musculus)	Kdm4a⁵ Jmjd2a¹	4 (56.50 cM)⁵	lysine (K)-specific demethylase 4A⁵ jumonji domain containing 2A¹	87.1(n)¹ 93.13(a)¹	230674¹ NM_172382.1¹ NP_759014.1¹ AK054095⁵ AK129187⁵ (see all 13)

About this table Species with no ortholog for KDM4A

ENSEMBL Gene Tree for KDM4A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KDM4A gene

KDM4D² JARID2² KDM4C² KDM4B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/258 NCBI SNPs in KDM4A are shown (see all 258 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 90)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs513862^1,2	A,C,F,H	43886992(-)	`ATCTTA/TAAAAA`	1	--	ng5¹ tfbs³		4		EU EA WA	418
	rs586339^1,2	A,C,F,H	43909844(-)	`CTGCTT/GCTTGT`	1	E/A	mis¹ ese³		15		MN EU EA WA NA	2794
	rs617521^1,2	A,C,F,H	43886786(+)	`ccgcaT/Ggattt`	1	--	ng5¹		18		NS MN EU EA WA NA	1580
--	rs519357^1,2	A,C	43887609(+)	`cctcaA/Gcctcc`	1	--	ng5¹		0	--	--	--	--
--	rs631758^1,2	A,C	43887641(+)	`atgcaA/Ccacca`	1	--	ng5¹		0	--	--	--	--
	rs12759032^1,2	H	43933112(+)	`TGTGGT/GCTTCA`	1	G/V	mis¹		4		EU EA WA	420
--	rs640762^1,2	A,C,F,H	43893938(+)	`GTGACG/TGGGCA`	1	T/T	syn¹ ese³		11		NA EU EA WA	764
	rs35964309^1,2	C	43929270(-)	`GAAACG/AAGTAT`	1	L/L	syn¹		1		NA	76
	rs35317523^1,2	F	43909878(-)	`ACAGAC/TGCAGG`	1	A/A	syn¹		1		NA	72
	rs607062^1,2	A,C,F,H,O	43905603(-)	`GATAAG/ACAAGA`	1	--	int¹		15		EA NA EU WA	1106

About this table

HapMap Linkage Disequilibrium images for KDM4A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609764

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/25 PubMed articles for KDM4A gene (see all 25 ):

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{2, 3, 4} Ishikawa K....Ohara O. (1998)
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). (PubMed id 16024779)^{1, 3, 4} Zhang D.... Wong J. (2005)
Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. (PubMed id 15927959)^{1, 3, 4} Gray S.G.... Dangond F. (2005)
Identification and characterization of JMJD2 family genes in silico. (PubMed id 15138608)^{1, 2, 3} Katoh M. and Katoh M. (2004)
Structural insights into histone demethylation by JMJD2 family members. (PubMed id 16677698)^{1, 3, 4} Chen Z.... Zhang G. (2006)
Recognition of histone H3 lysine-4 methylation by the double Tudor domain of JMJD2A. (PubMed id 16601153)^{1, 3, 4} Huang Y.... Xu R.-M. (2006)
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (PubMed id 16603238)^{1, 3, 4} Whetstine J.R.... Shi Y. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Tudor, MBT and chromo domains gauge the degree of lysine methylation. (PubMed id 16415788)^{3, 4} Kim J....Bedford M.T. (2006)
Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384)^{3, 4} Tao W.A.... Aebersold R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9682	HGNC: 22978	AceView: JMJD2A	Ensembl:ENSG00000066135	euGenes: HUgn9682
ECgene: KDM4A	H-InvDB: KDM4A

(According to HUGE)
About This Section

HUGE: KIAA0677

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for KDM4A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KDM4A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDM4A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDM4A		Antibodies for KDM4A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KDM4A		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (JMJD2A)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for KDM4A (JMJD2A)

	Recombinant Proteins (KDM4A / JHDM3A / JMJD2A)
	Antibodies (KDM4A / JHDM3A / JMJD2A)

Search OriGene for KDM4A

Search Tocris compounds for KDM4A

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for JMJD2A

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
KDM4A Gene at Home site.
Version 2.41.1
server5.xennexinc.com

KDM4A Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for KDM4A

Summaries
for KDM4A

Genomic Location
for KDM4A

Proteins
for KDM4A

Protein Domains/
Families
for KDM4A

Gene Function
for KDM4A

Pathways & Interactions
for KDM4A

Drugs & Compounds
for KDM4A

Transcripts
for KDM4A

Expression
for KDM4A

Orthologs
for KDM4A

Paralogs
for KDM4A

SNPs/Variants
for KDM4A

Disorders & Mutations
for KDM4A

Medical News
for KDM4A

Publications
for KDM4A

Search for KDM4A

Genome Databases showing KDM4A

Other Databases showing KDM4A

Specialized Databases showing KDM4A

Licensable Technologies
for KDM4A

Services
for KDM4A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDM4A Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor KDM4A

Summariesfor KDM4A

Genomic Locationfor KDM4A

Proteinsfor KDM4A

Protein Domains/Familiesfor KDM4A

Gene Functionfor KDM4A

Pathways & Interactionsfor KDM4A

Drugs & Compoundsfor KDM4A

Transcriptsfor KDM4A

Expression for KDM4A

Orthologsfor KDM4A

Paralogsfor KDM4A

SNPs/Variantsfor KDM4A

Disorders & Mutationsfor KDM4A

Medical Newsfor KDM4A

Publicationsfor KDM4A

Search for KDM4A

Genome Databases showing KDM4A

Other Databases showing KDM4A

Specialized Databases showing KDM4A

Licensable Technologiesfor KDM4A

Servicesfor KDM4A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDM4A

Summaries
for KDM4A

Genomic Location
for KDM4A

Proteins
for KDM4A

Protein Domains/
Families
for KDM4A

Gene Function
for KDM4A

Pathways & Interactions
for KDM4A

Drugs & Compounds
for KDM4A

Transcripts
for KDM4A

Expression
for KDM4A

Orthologs
for KDM4A

Paralogs
for KDM4A

SNPs/Variants
for KDM4A

Disorders & Mutations
for KDM4A

Medical News
for KDM4A

Publications
for KDM4A

Licensable Technologies
for KDM4A

Services
for KDM4A