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JMJD1C Gene

protein-coding   GIFtS: 62
GCID: GC10M064926

Jumonji Domain Containing 1C

(Previous name: thyroid hormone receptor interactor 8)
(Previous symbol: TRIP8)
  Search for JMJD1C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jumonji Domain Containing 1C1 2     Probable JmjC Domain-Containing Histone Demethylation Protein 2C2
TRIP81 2 3     Thyroid Receptor Interacting Protein 82
Thyroid Hormone Receptor Interactor 81 2     EC 1.14.11.-3
Jumonji Domain-Containing Protein 1C2 3     JHDM2C3
Thyroid Receptor-Interacting Protein 82 3     KIAA13803
TRIP-82 3     EC 1.14.118
TR-Interacting Protein 82 3     

External Ids:    HGNC: 123131   Entrez Gene: 2210372   Ensembl: ENSG000001719887   OMIM: 6045035   UniProtKB: Q156523   

Export aliases for JMJD1C gene to outside databases

Previous GC identifers: GC10M064272 GC10M064597 GC10M058918


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JMJD1C Gene:
JMJD1C (jumonji domain containing 1C) is a protein-coding gene. GO annotations related to this gene include thyroid hormone receptor binding and dioxygenase activity. An important paralog of this gene is KDM3B.

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a
central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved
in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target
genes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JMJD1C gene promoter:
         Egr-3   E2F-3a   E2F-4   E2F-5   Nkx2-5   E2F-2   CREB   E2F-1   E2F   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJMJD1C promoter sequence
   Search Chromatin IP Primers for JMJD1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JMJD1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

JMJD1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD1C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M064926:  view genomic region     (about GC identifiers)

Start:
64,926,981 bp from pter      End:
65,225,722 bp from pter
Size:
298,742 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652 (See protein sequence)
Recommended Name: Probable JmjC domain-containing histone demethylation protein 2C  
Size: 2540 amino acids; 284525 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence
of thyroid hormone for its interaction
Sequence caution: Sequence=AAC41741.1; Type=Frameshift; Positions=2171; Sequence=CAD97921.1; Type=Frameshift;
Positions=1697; Sequence=CAI10947.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for JMJD1C:
2YPD (3D)    
Secondary accessions: A0T124 Q5SQZ8 Q5SQZ9 Q5SR00 Q7Z3E7 Q8N3U0 Q96KB9 Q9P2G7
Alternative splicing: 3 isoforms:  Q15652-1   Q15652-2   Q15652-3   (May function as a tumor suppressor, reduced expression in breast cancer tumors)

Explore the universe of human proteins at neXtProt for JMJD1C: NX_Q15652

Explore proteomics data for JMJD1C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for JMJD1C (Q15652) (see all 6)
     KCRECRL  GVREMCD  SPVFCRF  ECWKQGQP 


    See JMJD1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001269877.1  NP_116165.1  

    ENSEMBL proteins: 
     ENSP00000382204   ENSP00000335929   ENSP00000444682   ENSP00000384990   ENSP00000382195  
    Reactome Protein details: Q15652

    JMJD1C Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for JMJD1C

     
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    Search eBioscience for ELISAs for JMJD1C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q15652

    ProtoNet protein and cluster: Q15652

    UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By
    similarity)
    Similarity: Belongs to the JHDM2 histone demethylase family
    Similarity: Contains 1 JmjC domain


    Find genes that share domains with JMJD1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JHD2C_HUMAN, Q15652
    Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a
    central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved
    in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target
    genes (By similarity)

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17353003
    GO:0046872metal ion binding IEA--
    GO:0046966thyroid hormone receptor binding TAS7776974
    GO:0051213dioxygenase activity IEA--
         
    Find genes that share ontologies with JMJD1C           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Jmjd1c):
     cellular  endocrine/exocrine gland  mortality/aging  reproductive system  skeleton 

    Find genes that share phenotypes with JMJD1C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Jmjd1ctm1Mtac for JMJD1C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JMJD1C
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    miRNA
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    miRTarBase miRNAs that target JMJD1C:
    hsa-mir-326 (MIRT043658), hsa-let-7e-5p (MIRT051502)

    Block miRNA regulation of human, mouse, rat JMJD1C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JMJD1C (see all 60):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-3616-5p hsa-miR-200a hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidJMJD1C 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JHD2C_HUMAN, Q15652: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS7776974
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with JMJD1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JMJD1C About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production


    Find genes that share SuperPaths with JMJD1C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for JMJD1C
        Factors involved in megakaryocyte development and platelet production


    1 Kegg Pathway  (Kegg details for JMJD1C):
        Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JMJD1C
    Interactions:

        Search GeneGlobe Interaction Network for JMJD1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for JMJD1C (Q156521, 2, 3 ENSP000003822044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-1224969,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    GADD45AP245222, 3MINT-8255879 I2D: score=2 
    NUDT21O438092, 3MINT-8264391 I2D: score=2 
    TK1P041832, 3MINT-8273609 I2D: score=2 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS7776974
    GO:0007596blood coagulation TAS--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with JMJD1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JMJD1C (JHD2C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JMJD1C gene (3 alternative transcripts): 
    NM_004241.2  NM_001282948.1  NM_032776.2  

    Unigene Cluster for JMJD1C:

    Jumonji domain containing 1C
    Hs.413416  [show with all ESTs]
    Unigene Representative Sequence: NM_032776
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467356(uc001jmk.3) ENST00000399262(uc001jmn.3) ENST00000327520(uc001jmo.3)
    ENST00000497922 ENST00000490669 ENST00000483298 ENST00000469152 ENST00000489372
    ENST00000542921(uc009xpk.1) ENST00000402544(uc001jml.3 uc001jmm.3 uc010qiq.2 uc009xpj.2 uc001jmp.1)
    ENST00000399251(uc001jmr.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate JMJD1C (see all 60):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-3616-5p hsa-miR-200a hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidJMJD1C 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat JMJD1C
      QuantiFast Probe-based Assays in human, mouse, rat JMJD1C

    Additional mRNA sequence: 

    AB037801.1 AK024991.1 AK027280.1 AK056660.1 AK095584.1 AK123507.1 AK126040.1 AL831917.1 
    BC026268.1 BC037981.1 BC047331.1 BC065742.1 BC067238.1 BC108649.1 BC126403.1 BC143722.1 
    BX537954.1 EF068222.1 L40411.1 

    24 DOTS entries:

    DT.100760960  DT.100761829  DT.101984094  DT.95370939  DT.444405  DT.212378  DT.121260092  DT.92045498 
    DT.40233822  DT.87014691  DT.40302170  DT.110581  DT.121260224  DT.92428572  DT.95367093  DT.95370938 
    DT.95370942  DT.108299  DT.121260010  DT.91697647  DT.91789642  DT.92057715  DT.92443085  DT.40241652 

    Selected AceView cDNA sequences (see all 232):

    AA910463 BX401568 CF137402 CK819566 CD723590 AI969488 AI005429 N92632 
    AK126040 BU683072 AI524452 BQ949626 CD677549 BG945018 CA438684 BU608390 
    CR607761 AI467861 CB268366 AL043246 AA347511 CD673964 AA953682 T32742 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for JMJD1C (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                      -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c · 26d
    SP1:        -     -           -           -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for JMJD1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JMJD1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAATCAG
    JMJD1C Expression
    About this image


    JMJD1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Stomach (Gastrointestinal Tract)
    JMJD1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JMJD1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413416
        Custom PCR Arrays for JMJD1C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for JMJD1C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jmjd1c1 , 5 jumonji domain containing 1C1, 5 86.77(n)1
    86.65(a)1
      10 (34.85 cM)5
    1088291  NM_207221.21  NP_997104.21 
     670961255 
    chicken
    (Gallus gallus)
    Aves JMJD1C1 jumonji domain containing 1C 78.13(n)
    78.86(a)
      423655  NM_001199546.1  NP_001186475.1 
    lizard
    (Anolis carolinensis)
    Reptilia JMJD1C6
    jumonji domain containing 1C
    72(a)
    1 ↔ 1
    GL343204.1(2381158-2505207)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330452 Xenopus laevis transcribed sequence with weak similarity more 72.73(n)    BU916031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jmjd1cb1 jumonji domain containing 1Cb 61.82(n)
    61.98(a)
      558436  XM_681650.6  XP_686742.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta JHDM26
    JmjC domain-containing histone demethylase 2
    37(a)
    1 → many
    3R(5341731-5346660)


    ENSEMBL Gene Tree for JMJD1C (if available)
    TreeFam Gene Tree for JMJD1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JMJD1C gene
    KDM3B2  KDM3A2  HR2  
    3 SIMAP similar genes for JMJD1C using alignment to 4 protein entries:     JHD2C_HUMAN (see all proteins):
    KDM3B    KDM3A    JMJD1B

    Find genes that share paralogs with JMJD1C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JMJD1C (see all 5822)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927809041,2
    --64926501(+) TATAGA/GTAATT 2 -- int10--------
    rs1852111451,2
    --64926518(+) AAATGC/TCACAT 2 -- int10--------
    rs563787431,2
    C,F--64926536(+) ATTCAC/AATGAA 2 -- int15Minor allele frequency- A:0.17NA EA 246
    rs1900941091,2
    --64926544(+) GAAATA/GTAATT 2 -- int10--------
    rs2006720261,2
    C--64926685(+) CCACT-/TTTTC 
            
    TTTCT
    2 -- int10--------
    rs571263331,2
    C,F--64926719(+) AGAAGC/AAAGGC 2 -- int12Minor allele frequency- A:0.25WA CSA 4
    rs568084731,2
    C--64926722(+) GAAAGAAAG/-  
            
    GCTAT
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs780333461,2
    C,F--64926827(+) AGCCAG/ACTATT 2 -- int11Minor allele frequency- A:0.01NA 120
    rs1464091561,2
    --64926979(+) GAAAAA/CGTCAA 2 -- int10--------
    rs1408243891,2
    --64927152(+) TATTTA/CGCTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for JMJD1C (64926981 - 65176981 bp, first 250kb of JMJD1C)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for JMJD1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658212CNV Deletion23128226
    esv2665134CNV Deletion23128226
    esv2660838CNV Deletion23128226
    esv2677353CNV Deletion23128226
    nsv510223CNV Loss20534489
    nsv831892CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): JMJD1C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JMJD1C
    DNA2.0 Custom Variant and Variant Library Synthesis for JMJD1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604503    OMIM disorders: --


    Find genes that share disorders with JMJD1C           About GenesLikeMe

    Genetic Association Database (GAD): JMJD1C
    Human Genome Epidemiology (HuGE) Navigator: JMJD1C (6 documents)

    Export disorders for JMJD1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JMJD1C gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with JMJD1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    2. Identification and characterization of TRIP8 gene in silico. (PubMed id 14533015)1, 2, 9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2003)
    3. Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1, 4 Thompson S.D....Glass D.N. (Arthritis Rheum. 2012)
    4. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (PLoS Genet. 2012)
    5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    6. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    7. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PubMed id 20526338)1, 4 Johnson A.D....Becker L.C. (Nat. Genet. 2010)
    8. PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease. (PubMed id 20648472)1, 4 Speliotes E.K....Hirschhorn J.N. (Hepatology 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221037 HGNC: 12313 AceView: JMJD1C Ensembl:ENSG00000171988 euGenes: HUgn221037
    ECgene: JMJD1C Kegg: 221037 H-InvDB: JMJD1C

    (According to HUGE)
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    HUGE: KIAA1380

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for JMJD1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JMJD1C gene:
    Search GeneIP for patents involving JMJD1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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