Free for academic non-profit institutions. Other users need a Commercial license

Aliases for JMJD1C Gene

Aliases for JMJD1C Gene

  • Jumonji Domain Containing 1C 2 3
  • Thyroid Receptor-Interacting Protein 8 3 4
  • Thyroid Hormone Receptor Interactor 8 2 3
  • Jumonji Domain-Containing Protein 1C 3 4
  • TR-Interacting Protein 8 3 4
  • TRIP-8 3 4
  • TRIP8 3 4
  • Probable JmjC Domain-Containing Histone Demethylation Protein 2C 3
  • Thyroid Receptor Interacting Protein 8 3
  • EC 1.14.11.- 4
  • EC 1.14.11 64
  • KIAA1380 4
  • JHDM2C 4

External Ids for JMJD1C Gene

Previous Symbols for JMJD1C Gene

  • TRIP8

Summaries for JMJD1C Gene

GeneCards Summary for JMJD1C Gene

JMJD1C (Jumonji Domain Containing 1C) is a Protein Coding gene. Diseases associated with JMJD1C include central nervous system germinoma. Among its related pathways are Hemostasis and Transcriptional misregulation in cancer. GO annotations related to this gene include thyroid hormone receptor binding and dioxygenase activity. An important paralog of this gene is HR.

UniProtKB/Swiss-Prot for JMJD1C Gene

  • Probable histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JMJD1C Gene

Genomics for JMJD1C Gene

Genomic Location for JMJD1C Gene

Start:
63,167,221 bp from pter
End:
63,521,844 bp from pter
Size:
354,624 bases
Orientation:
Minus strand

Genomic View for JMJD1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JMJD1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JMJD1C Gene

Regulatory Elements for JMJD1C Gene

Proteins for JMJD1C Gene

  • Protein details for JMJD1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15652-JHD2C_HUMAN
    Recommended name:
    Probable JmjC domain-containing histone demethylation protein 2C
    Protein Accession:
    Q15652
    Secondary Accessions:
    • A0T124
    • Q5SQZ8
    • Q5SQZ9
    • Q5SR00
    • Q7Z3E7
    • Q8N3U0
    • Q96KB9
    • Q9P2G7

    Protein attributes for JMJD1C Gene

    Size:
    2540 amino acids
    Molecular mass:
    284525 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    • Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction.
    SequenceCaution:
    • Sequence=AAC41741.1; Type=Frameshift; Positions=2171; Evidence={ECO:0000305}; Sequence=CAD97921.1; Type=Frameshift; Positions=1697; Evidence={ECO:0000305}; Sequence=CAI10947.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for JMJD1C Gene

    Alternative splice isoforms for JMJD1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JMJD1C Gene

Proteomics data for JMJD1C Gene at MOPED

Selected DME Specific Peptides for JMJD1C Gene

Post-translational modifications for JMJD1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JMJD1C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for JMJD1C Gene

Protein Domains for JMJD1C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

JHD2C_HUMAN
Domain:
  • Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.:
    • Q15652
  • Contains 1 JmjC domain.:
    • Q15652
Family:
  • Belongs to the JHDM2 histone demethylase family.:
    • Q15652
genes like me logo Genes that share domains with JMJD1C: view

No data available for Gene Families for JMJD1C Gene

Function for JMJD1C Gene

Molecular function for JMJD1C Gene

UniProtKB/Swiss-Prot Function: Probable histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity).

Enzyme Numbers (IUBMB) for JMJD1C Gene

Gene Ontology (GO) - Molecular Function for JMJD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353003
GO:0046872 metal ion binding IEA --
GO:0046966 thyroid hormone receptor binding TAS 7776974
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with JMJD1C: view
genes like me logo Genes that share phenotypes with JMJD1C: view

Animal Models for JMJD1C Gene

MGI Knock Outs for JMJD1C:

miRNA for JMJD1C Gene

miRTarBase miRNAs that target JMJD1C

No data available for Transcription Factor Targeting and HOMER Transcription for JMJD1C Gene

Localization for JMJD1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for JMJD1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JMJD1C Gene COMPARTMENTS Subcellular localization image for JMJD1C gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for JMJD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular NAS 7776974
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with JMJD1C: view

Pathways for JMJD1C Gene

genes like me logo Genes that share pathways with JMJD1C: view

Pathways by source for JMJD1C Gene

Gene Ontology (GO) - Biological Process for JMJD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7776974
GO:0007596 blood coagulation TAS --
GO:0016568 chromatin modification IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with JMJD1C: view

Transcripts for JMJD1C Gene

Unigene Clusters for JMJD1C Gene

Jumonji domain containing 1C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JMJD1C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9:

ExUns: 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c · 26d
SP1: - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8: -
SP9:

Relevant External Links for JMJD1C Gene

GeneLoc Exon Structure for
JMJD1C
ECgene alternative splicing isoforms for
JMJD1C

Expression for JMJD1C Gene

mRNA expression in normal human tissues for JMJD1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for JMJD1C Gene

SOURCE GeneReport for Unigene cluster for JMJD1C Gene Hs.413416

genes like me logo Genes that share expressions with JMJD1C: view

Orthologs for JMJD1C Gene

This gene was present in the common ancestor of animals.

Orthologs for JMJD1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JMJD1C 36
  • 99.84 (n)
  • 99.84 (a)
JMJD1C 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JMJD1C 36
  • 92.23 (n)
  • 92.14 (a)
JMJD1C 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JMJD1C 36
  • 92.63 (n)
  • 92.28 (a)
JMJD1C 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jmjd1c 36
  • 86.77 (n)
  • 86.65 (a)
Jmjd1c 16
Jmjd1c 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JMJD1C 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JMJD1C 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jmjd1c 36
  • 84.56 (n)
  • 85.17 (a)
chicken
(Gallus gallus)
Aves JMJD1C 36
  • 78.13 (n)
  • 78.86 (a)
JMJD1C 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JMJD1C 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33045 36
tropical clawed frog
(Silurana tropicalis)
Amphibia jmjd1c 36
  • 68.08 (n)
  • 67.12 (a)
zebrafish
(Danio rerio)
Actinopterygii JMJD1C 37
  • 37 (a)
OneToOne
jmjd1cb 36
  • 61.82 (n)
  • 61.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta JHDM2 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7055 37
  • 36 (a)
OneToMany
Species with no ortholog for JMJD1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JMJD1C Gene

ENSEMBL:
Gene Tree for JMJD1C (if available)
TreeFam:
Gene Tree for JMJD1C (if available)

Paralogs for JMJD1C Gene

Paralogs for JMJD1C Gene

Selected SIMAP similar genes for JMJD1C Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with JMJD1C: view

Variants for JMJD1C Gene

Sequence variations from dbSNP and Humsavar for JMJD1C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs907 -- 63,176,919(+) CTAAC(A/G)CTTGA intron-variant
rs1935 - 63,168,063(-) GTAGA(C/G)GATAT missense, reference
rs14723 -- 63,167,655(+) GTAAC(C/T)GTCTC utr-variant-3-prime
rs724553 -- 63,380,624(+) aatca(C/G)ggtaa intron-variant
rs1044543 -- 63,222,562(+) CAGTT(A/T)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JMJD1C Gene

Variant ID Type Subtype PubMed ID
esv2677353 CNV Deletion 23128226
nsv510223 CNV Loss 20534489
esv2658212 CNV Deletion 23128226
nsv831892 CNV Gain+Loss 17160897
esv2660838 CNV Deletion 23128226
esv2665134 CNV Deletion 23128226

Relevant External Links for JMJD1C Gene

HapMap Linkage Disequilibrium report
JMJD1C
Human Gene Mutation Database (HGMD)
JMJD1C

Disorders for JMJD1C Gene

Relevant External Links for JMJD1C

Genetic Association Database (GAD)
JMJD1C
Human Genome Epidemiology (HuGE) Navigator
JMJD1C
genes like me logo Genes that share disorders with JMJD1C: view

No data available for UniProtKB/Swiss-Prot for JMJD1C Gene

Publications for JMJD1C Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  2. Identification and characterization of TRIP8 gene in silico. (PMID: 14533015) Katoh M. … Katoh M. (Int. J. Mol. Med. 2003) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for JMJD1C Gene

Sources for JMJD1C Gene

Back to Top

Content