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JMJD1C Gene

protein-coding GIFtS: 53

GC10M064597

jumonji domain containing 1C
(Previous name: thyroid hormone receptor interactor 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TRIP8)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp761F0118 ^¹, ²
EC 1.14.11.- ^³
FLJ14374 ^¹, ²
JHDM2C ^³
KIAA1380 ^¹, ², ³
OTTHUMP00000060747 ^²
RP11-10C13.2 ^²
TRIP-8 ^³
TRIP8 ^², ³

Descriptions
Jumonji domain-containing protein 1C ^³
Thyroid receptor-interacting protein 8 ^³
jumonji domain containing 1C ^²
thyroid hormone receptor interactor 8 ^¹, ²
thyroid receptor interacting protein 8 ^²

External Ids
HGNC: 12313¹
Entrez Gene: 221037²
UniProtKB: Q15652³
Ensembl: ENSG00000171988⁷

Search outside databases for aliases for JMJD1C gene

Previous GC identifer: GC10M064272

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652

Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3,

thereby playing a central role in histone code. Demethylation of Lys residue generates

formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by

participating in recruitment to androgen-receptor target genes (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the JMJD1C gene

Entrez Gene cytogenetic band: 10q21.2-q21.3 Ensembl cytogenetic band: 10q21.3 HGNC cytogenetic band: 10q22.1

JMJD1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M064597: (about GC identifiers)

Start:	64,596,987 bp from pter
End:	64,895,728 bp from pter
Size:	298,742 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652 (See protein sequence)

Recommended Name: Probable JmjC domain-containing histone demethylation protein 2C

Size: 2540 amino acids; 284525 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR).

Requires the presence of thyroid hormone for its interaction

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=AAC41741.1; Type=Frameshift; Positions=2171; Sequence=CAD97921.1;

Type=Frameshift; Positions=1697; Sequence=CAI10947.1; Type=Erroneous gene model prediction;

Secondary accessions: Q5SQZ8 Q5SQZ9 Q5SR00 Q7Z3E7 Q8N3U0 Q96KB9 Q9P2G7

Alternative splicing: 2 isoforms: Q15652-1 Q15652-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004232.2 NP_116165.1

ENSEMBL proteins:

ENSP00000384990 ENSP00000382195 ENSP00000335929 ENSP00000382204

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (JMJD1C)
	Human Recombinant Proteins from Abnova (JMJD1C)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	NAS	7776974
GO:0005634	nucleus	IEA	--

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Antibodies for JMJD1C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for JMJD1C
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (JMJD1C), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JMJD1C)
	Novus Biologicals Antibodies for JMJD1C

Assays for JMJD1C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15652

ProtoNet protein and cluster: Q15652

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652

Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear

receptors (By similarity)

Similarity: Belongs to the JHDM2 histone demethylase family

Similarity: Contains 1 JmjC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JMJD1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD1C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004241

Applied Biosystems Silencer® siRNAs for JMJD1C

Sigma-Aldrich siRNA for JMJD1C

Sigma-Aldrich shRNA for JMJD1C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004241
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004241
untagged cDNA clones in CMV expression vector (see all 3): AK027280

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032776

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652

Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3,

thereby playing a central role in histone code. Demethylation of Lys residue generates

formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by

participating in recruitment to androgen-receptor target genes (By similarity)

Enzyme Number (IUBMB): EC 1.14.11.-

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	17353003
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Interacting proteins for JMJD1C (ENSP00000335929³ Q15652¹) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AR	P10275¹	EBI-1224969, EBI-608057
THRB	ENSP00000280696³	STRING (score=.975)
KDM4B	ENSP00000159111³	STRING (score=.953)
KDM4A	ENSP00000361473³	STRING (score=.948)
KDM4D	ENSP00000334181³	STRING (score=.885)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	7776974
GO:0016568	chromatin modification	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JMJD1C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JMJD1C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JMJD1C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004241

Sigma-Aldrich siRNA for JMJD1C

Sigma-Aldrich shRNA for JMJD1C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004241 NM_032776

REFSEQ mRNAs for JMJD1C gene (2 alternative transcripts):

NM_004241.2 NM_032776.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004241 NM_032776

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004241
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004241
                                 untagged cDNA clones in CMV expression vector (see all 3): AK027280

Additional cDNA sequence:

AB037801.1 AK024991.1 AK027280.1 AK055182.1 AK056660.1 AK095584.1 AK123507.1 AK126040.1

AL831917.1 BC026268.1 BC037981.1 BC047331.1 BC065742.1 BC067238.1 BC108649.1 BC126403.1

BC143722.1 BX537954.1 CR607761.1 CR619190.1 EF068222.1 L40411.1

24/26 DOTS entries (see all 26 ):

DT.100760960 DT.100761829 DT.101984094 DT.95370939 DT.444405 DT.212378 DT.75165986 DT.121260092

DT.92045498 DT.40302170 DT.40233822 DT.110581 DT.87014691 DT.92428572 DT.95367093 DT.95370938

DT.95370942 DT.121260010 DT.121260224 DT.91697647 DT.91789642 DT.92057715 DT.92443085 DT.102837256

24/232 AceView cDNA sequences (see all 232 ):

AL701177 AW089941 T16598 CK819567 AA644371 CF143208 CD723590 AA694142

AI005429 BG945018 BX507391 AA707793 AI860559 CB268366 CR619190 BF818641

AA620754 AK126040 AL043246 AL831917 AA953682 AW029467 AI219929 AW192227

highest scoring ESTs for JMJD1C:

AA557977 AA694142 AA732458 AA749173 AA815120 AI005429 AI694023 AI799534 AI903392 AK027280

Unigene Cluster for JMJD1C:

Jumonji domain containing 1C

Hs.413416 [show with all ESTs]

Unigene Representative Sequence: NM_032776

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD1C (see all 9 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:
SP2:																													-		-
SP3:
SP4:
SP5:									-

ExUns:	23a	·	23b	^	24a	·	24b	^	25a	·	25b	^	26a	·	26b	·	26c	·	26d
SP1:			-		-				-				-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for JMJD1C

4 Ensembl transcripts including schematic representations:

ENST00000402544 ENST00000399251 ENST00000327520 ENST00000399262

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

JMJD1C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JMJD1C

¹ / ² / ³

15 probe-sets matching JMJD1C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54579_at²^{, 3}	U95-B	1	1.00	1.00	0.86	0.81	AI799534	0.80	1.00	0.91	1
64893_at²^{, 3}	U95-C	1	1.00	1.00	0.61	1.53	AI694023	0.80	1.00	0.91	1
38216_at²^{, 3}	U95-A	1	1.00	1.00	0.76	0.77	L40411	0.60	1.00	0.82	1
88751_at²^{, 3}	U95-E	1	0.69	1.00	0.51	0.92	AI767252	0.40	0.67	0.55	1
44312_at²^{, 3}	U95-B	1	0.38	1.00	-0.16	0.23	T95865	0.20	0.50	0.38	1
224933_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA425650	0.60	1.00	0.82	1
221763_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI694023	0.80	1.00	0.91	1
230007_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI767252	0.40	0.67	0.55	1
241661_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA001021	0.60	1.00	0.82	1
228793_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF002296	0.60	1.00	0.82	1
224933_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221763_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230007_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241661_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228793_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCATAATCAG

SOURCE GeneReport for Unigene cluster: Hs.413416
Expression variation in blood from EXPOLDB for JMJD1C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JMJD1C gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JMJD1C¹	--	jumonji domain containing 1C	92.62(n) 92.3(a)	479221 XM_536363.2 XP_536363.2
chimpanzee (Pan troglodytes)	JMJD1C¹	--	jumonji domain containing 1C	99.84(n) 99.84(a)	450489 XM_001166111.1 XP_001166111.1
cow (Bos taurus)	JMJD1C¹	--	jumonji domain containing 1C	92.23(n) 92.14(a)	781067 XM_001249360.1 XP_001249361.1
rat (Rattus norvegicus)	Jmjd1c¹	--	jumonji domain containing 1C	84.75(n) 85.37(a)	171120 XM_228122.4 XP_228122.4
mouse (Mus musculus)	Jmjd1c^{1, 5}	10⁵	jumonji domain containing 1C^{1, 5}	86.77(n)¹ 86.65(a)¹	108829¹ XM_975833.2¹ XP_980927.2¹ AI449362⁵ AK077400⁵ (see all 23)

About this table Species with no ortholog for JMJD1C

ENSEMBL Gene Tree for JMJD1C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JMJD1C gene

KDM3B² KDM3A² HR²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1585 NCBI SNPs in JMJD1C are shown (see all 1585 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1935^1,2	A,C,F,H	64597829(-)	`GTAGAG/CGATAT`	2	D/E	mis¹ ese³		23		NS MN EA NA EU WA	1710
	rs10761725^1,2	A,C,F,H	64644543(+)	`TGACGT/AATGAA`	2	T/S	mis¹ ese³		13		EU EA WA NA	1326
--	rs4747162^1,2	A,C,H	64700365(+)	`GTAGAT/AGGGAC`	2	--	int¹ ng3¹		3		EA WA	298
	rs9703886^1,2	C,H	64637258(+)	`GGTATT/AACACA`	2	Y/N	mis¹ ese³		8		EU EA WA	830
	rs34798625^1,2	C,F	64645327(+)	`AACAGC/TGTTGA`	2	A/T	mis¹		5		NA EU EA WA	496
	rs35380596^1,2	C,F	64644751(+)	`TTCTGT/GTCTGA`	2	D/E	mis¹		5		NA EU EA WA	478
	rs34491125^1,2	C,F	64607507(+)	`ATCTTG/CTCAAC`	2	E/D	mis¹		5		NA EU EA WA	488
	rs14723^1,2	F	64597421(+)	`GTAACT/CGTCTC`	2	--	ut3¹ ese³		1		MN	184
	rs12219953^1,2	H	64637821(+)	`GTGCTC/ATATGT`	2	I/R	mis¹		4		EU EA WA	420
--	rs7081938^1,2	A	64699007(+)	`GGCACA/GCTGAG`	2	--	ng3¹ int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for JMJD1C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604503

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/15 PubMed articles for JMJD1C gene (see all 15 ):

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)^{2, 3, 4} Lee J.W....Moore D.D. (1995)
Identification and characterization of TRIP8 gene in silico. (PubMed id 14533015)^{1, 3, 4} Katoh M. and Katoh M. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{3, 4} Nagase T....Ohara O. (2000)
Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer. (PubMed id 17549425)^{1, 3} Katoh M. and Katoh M. (2007)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)³ Yuan X....Mooser V. (2008)
A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. (PubMed id 17353003)³ Wolf S.S.... Obendorf M. (2007)
Identification and characterization of the TRIP8 and REEP3 genes on chromosome 10q21.3 as novel candidate genes for autism. (PubMed id 17290275)³ Castermans D....Devriendt K. (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)⁴ Matsuoka S.... Elledge S.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 221037	HGNC: 12313	AceView: JMJD1C	Ensembl:ENSG00000171988	euGenes: HUgn221037
ECgene: JMJD1C	H-InvDB: JMJD1C

(According to HUGE)
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HUGE: KIAA1380

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for JMJD1C
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for JMJD1C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JMJD1C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JMJD1C		Antibodies for JMJD1C
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for JMJD1C		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for JMJD1C

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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JMJD1C Gene at Home site.
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JMJD1C Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for JMJD1C

Summaries
for JMJD1C

Genomic Location
for JMJD1C

Proteins
for JMJD1C

Protein Domains/
Families
for JMJD1C

Gene Function
for JMJD1C

Pathways & Interactions
for JMJD1C

Drugs & Compounds
for JMJD1C

Transcripts
for JMJD1C

Expression
for JMJD1C

Orthologs
for JMJD1C

Paralogs
for JMJD1C

SNPs/Variants
for JMJD1C

Disorders & Mutations
for JMJD1C

Medical News
for JMJD1C

Publications
for JMJD1C

Search for JMJD1C

Genome Databases showing JMJD1C

Other Databases showing JMJD1C

Specialized Databases showing JMJD1C

Licensable Technologies
for JMJD1C

Services
for JMJD1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JMJD1C Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor JMJD1C

Summariesfor JMJD1C

Genomic Locationfor JMJD1C

Proteinsfor JMJD1C

Protein Domains/Familiesfor JMJD1C

Gene Functionfor JMJD1C

Pathways & Interactionsfor JMJD1C

Drugs & Compoundsfor JMJD1C

Transcriptsfor JMJD1C

Expression for JMJD1C

Orthologsfor JMJD1C

Paralogsfor JMJD1C

SNPs/Variantsfor JMJD1C

Disorders & Mutationsfor JMJD1C

Medical Newsfor JMJD1C

Publicationsfor JMJD1C

Search for JMJD1C

Genome Databases showing JMJD1C

Other Databases showing JMJD1C

Specialized Databases showing JMJD1C

Licensable Technologiesfor JMJD1C

Servicesfor JMJD1C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JMJD1C

Summaries
for JMJD1C

Genomic Location
for JMJD1C

Proteins
for JMJD1C

Protein Domains/
Families
for JMJD1C

Gene Function
for JMJD1C

Pathways & Interactions
for JMJD1C

Drugs & Compounds
for JMJD1C

Transcripts
for JMJD1C

Expression
for JMJD1C

Orthologs
for JMJD1C

Paralogs
for JMJD1C

SNPs/Variants
for JMJD1C

Disorders & Mutations
for JMJD1C

Medical News
for JMJD1C

Publications
for JMJD1C

Licensable Technologies
for JMJD1C

Services
for JMJD1C