Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JMJD1C Gene

protein-coding   GIFtS: 57
GCID: GC10M064926

jumonji domain containing 1C

(Previous name: thyroid hormone receptor interactor 8 )
(Previous symbol: TRIP8)
 Explore 6 diseases affiliated with
JMJD1C via our new
 Human Malady Compendium 
Biological research products
for JMJD1C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Jumonji Domain Containing 1C1 2     DKFZp761F01181
TRIP81 2 3     FLJ143741
Thyroid Hormone Receptor Interactor 81 2     RP11-10C13.22
KIAA13801 3     Probable JmjC Domain-Containing Histone Demethylation Protein 2C2
Jumonji Domain-Containing Protein 1C2 3     Thyroid Receptor Interacting Protein 82
Thyroid Receptor-Interacting Protein 82 3     EC 1.14.11.-3
TRIP-82 3     JHDM2C3
TR-Interacting Protein 82 3     EC 1.14.118

External Ids:    HGNC: 123131   Entrez Gene: 2210372   Ensembl: ENSG000001719887   OMIM: 6045035   UniProtKB: Q156523   

Export aliases for JMJD1C gene to outside databases

Previous GC identifers: GC10M064272 GC10M064597 GC10M058918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central
role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in
hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JMJD1C gene promoter:
         Egr-3   E2F-3a   E2F-4   E2F-5   Nkx2-5   E2F-2   CREB   E2F-1   E2F   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJMJD1C promoter sequence
   Search SABiosciences Chromatin IP Primers for JMJD1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

JMJD1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD1C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M064926:  view genomic region     (about GC identifiers)

Start:
64,926,981 bp from pter      End:
65,225,722 bp from pter
Size:
298,742 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652 (See protein sequence)
Recommended Name: Probable JmjC domain-containing histone demethylation protein 2C  
Size: 2540 amino acids; 284525 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of
thyroid hormone for its interaction
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAC41741.1; Type=Frameshift; Positions=2171; Sequence=CAD97921.1; Type=Frameshift;
Positions=1697; Sequence=CAI10947.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for JMJD1C:
2YPD (3D)    
Secondary accessions: A0T124 Q5SQZ8 Q5SQZ9 Q5SR00 Q7Z3E7 Q8N3U0 Q96KB9 Q9P2G7
Alternative splicing: 3 isoforms:  Q15652-1   Q15652-2   Q15652-3   (May function as a tumor suppressor, reduced expression in breast cancer tumors)

Explore the universe of human proteins at neXtProt for JMJD1C: NX_Q15652

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15652

  • 4/6 DME Specific Peptides for JMJD1C (Q15652) (see all 6)
     KCRECRL  GVREMCD  SPVFCRF  ECWKQGQP 

    JMJD1C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004232.2  NP_116165.1  

    ENSEMBL proteins: 
     ENSP00000382204   ENSP00000450666   ENSP00000335929   ENSP00000444682   ENSP00000384990  
     ENSP00000382195  
    Reactome Protein details: Q15652
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for JMJD1C 
    GenScript Custom Purified and Recombinant Proteins Services for JMJD1C
    Novus Biologicals JMJD1C Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for JMJD1C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS7776974
    GO:0005654nucleoplasm TAS--


    JMJD1C for ontologies           About GeneDecksing



    JMJD1C Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of JMJD1C
    Browse R&D Systems for Antibodies
    OriGene Antibodies: JMJD1C
    OriGene Custom Antibody Services for JMJD1C 
    GenScript Custom Superior Antibodies Services for JMJD1C
    Novus Biologicals JMJD1C Antibodies
    Search for Antibodies for JMJD1C at Abcam  
    Uscn Antibodies for JMJD1C
    ThermoFisher Antibodies for JMJD1C

    Assay Products for JMJD1C: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JMJD1C
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for JMJD1C


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    JMJD1C for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q15652

    ProtoNet protein and cluster: Q15652

    UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity)
    Similarity: Belongs to the JHDM2 histone demethylase family
    Similarity: Contains 1 JmjC domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
    Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central
    role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in
    hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By
    similarity)

    Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): JMJD1C
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JMJD1C
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate JMJD1C (see all 60):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-3616-5p hsa-miR-200a hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidJMJD1C 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene shRNA RFP: JMJD1C
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JMJD1C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JMJD1C

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): JMJD1C (NM_004241)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JMJD1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD1C 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JMJD1C
    Search LifeMap BioReagents cell lines for JMJD1C

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD1C

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17353003
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0046872metal ion binding IEA--
    GO:0046966thyroid hormone receptor binding TAS7776974


    JMJD1C for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production1.00
    2Platelet activation, signaling and aggregation
    Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for JMJD1C
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    JMJD1C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JMJD1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for JMJD1C (Q156521, 2, 3 ENSP000003822044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-1224969,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    GADD45AP245222, 3MINT-8255879 I2D: score=2 
    NUDT21O438092, 3MINT-8264391 I2D: score=2 
    TK1P041832, 3MINT-8273609 I2D: score=2 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS7776974
    GO:0007596blood coagulation TAS--
    GO:0016568chromatin modification IEA--


    JMJD1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JMJD1C
    Search CenterWatch for drugs/clinical trials and news about JMJD1C / JHD2C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JMJD1C gene (2 alternative transcripts): 
    NM_004241.2  NM_032776.1  

    Unigene Cluster for JMJD1C:

    Jumonji domain containing 1C
    Hs.413416  [show with all ESTs]
    Unigene Representative Sequence: NM_032776
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467356(uc001jmk.3) ENST00000399262(uc001jmn.3) ENST00000554702(uc009xpi.3)
    ENST00000327520(uc001jmo.3) ENST00000497922 ENST00000490669 ENST00000483298
    ENST00000469152 ENST00000489372 ENST00000542921(uc009xpk.1) ENST00000402544(uc001jml.3 uc001jmm.3 uc010qiq.2 uc009xpj.2 uc001jmp.1)
    ENST00000399251(uc001jmr.1)

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): JMJD1C
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JMJD1C
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate JMJD1C (see all 60):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-3616-5p hsa-miR-200a hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidJMJD1C 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene shRNA RFP: JMJD1C
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JMJD1C
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): JMJD1C (NM_004241)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JMJD1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD1C 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD1C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JMJD1C
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD1C
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD1C

    Additional cDNA sequence: 

    AB037801.1 AK024991.1 AK027280.1 AK056660.1 AK095584.1 AK123507.1 AK126040.1 AL831917.1 
    BC026268.1 BC037981.1 BC047331.1 BC065742.1 BC067238.1 BC108649.1 BC126403.1 BC143722.1 
    BX537954.1 EF068222.1 L40411.1 

    23 DOTS entries:

    DT.100760960  DT.100761829  DT.101984094  DT.95370939  DT.444405  DT.212378  DT.121260092  DT.92045498 
    DT.40233822  DT.40302170  DT.87014691  DT.110581  DT.92428572  DT.95367093  DT.95370938  DT.95370942 
    DT.121260010  DT.91697647  DT.91789642  DT.92057715  DT.92443085  DT.121260224  DT.40241652 

    24/232 AceView cDNA sequences (see all 232):

    CF143208 AA347511 AA707793 AA694142 AV699146 BX401568 CR607761 BQ185845 
    R20253 AI219929 CA313216 BC037981 BU542787 AW298543 BG945018 BF818641 
    AA644371 AW089941 CD677549 AK126040 AL701177 BX507391 CK819566 AW192227 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD1C (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                      -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c · 26d
    SP1:        -     -           -           -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for JMJD1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JMJD1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCATAATCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See JMJD1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JMJD1C

    SOURCE GeneReport for Unigene cluster: Hs.413416
        SABiosciences Custom PCR Arrays for JMJD1C
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD1C
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JMJD1C
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD1C
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD1C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for JMJD1C gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves JMJD1C1 jumonji domain containing 1C 78.05(n)
    78.82(a)
      423655  NM_001199546.1  NP_001186475.1 
    lizard
    (Anolis carolinensis)
    Reptilia JMJD1C6
    --
    72(a)
    1 ↔ 1
    GL343204.1(2441868-2505207)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330452 Xenopus laevis transcribed sequence with weak similarity more 72.73(n)    BU916031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jmjd1c1 jumonji domain containing 1C 61.52(n)
    61.78(a)
      558436  XM_681650.5  XP_686742.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta JHDM26
    JmjC domain-containing histone demethylase 2
    33(a)
    1 → many
    3R(5341731-5346660)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G009906
    AT1G623106
    (see all 6)
    Transcription factor jumonji (jmjC) domain-contain...
    transcription factor jumonji domain-containing pro...
    (see all 6)
    18(a)
    17(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    4(426944-431821)
    1(23036039-23039609)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 6)
    transcription factor jumonji, putative, expressed
    (see all 6)
    24(a)
    23(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    9(13351011-13353250)
    9(13594421-13600888)


    ENSEMBL Gene Tree for JMJD1C (if available)
    TreeFam Gene Tree for JMJD1C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JMJD1C gene
    KDM3B2  KDM3A2  HR2  
    3 SIMAP similar genes for JMJD1C using alignment to 5 protein entries:     JHD2C_HUMAN (see all proteins):
    KDM3B    JMJD1B    KDM3A

    JMJD1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4862 NCBI SNPs in JMJD1C are shown (see all 4862    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999269931,2
    C--58977369(-) GGGAAA/GGNNNN 1 -- int10--------
    rs1927809041,2
    --64926501(+) TATAGA/GTAATT 2 -- int10--------
    rs1852111451,2
    --64926518(+) AAATGC/TCACAT 2 -- int10--------
    rs563787431,2
    C,F,--64926536(+) ATTCAC/AATGAA 2 -- int15Minor allele frequency- A:0.17NA EA 246
    rs1900941091,2
    --64926544(+) GAAATA/GTAATT 2 -- int10--------
    rs2006720261,2
    --64926685(+) CACTT-/TTTTC 
            
    TTTTA
    2 -- int10--------
    rs1498297731,2
    C,--64926715(+) TTGAG-/AAGA  
            
    AAGAA
    2 -- int10--------
    rs571263331,2
    C,--64926719(+) AGAAGC/AAAGGC 2 -- int12Minor allele frequency- A:0.25WA CSA 4
    rs568084731,2
    C--64926722(+) GAAAGAAAG/-  
            
    GCTAT
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs780333461,2
    --64926827(+) AGCCAG/ACTATT 2 -- int11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for JMJD1C (64926981 - 65176981 bp, first 250kb of JMJD1C)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for JMJD1C
         1 CNV: 4697
    Human Gene Mutation Database (HGMD): JMJD1C

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD1C
    DNA2.0 Custom Variant and Variant Library Synthesis for JMJD1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    JMJD1C for disorders           About GeneDecksing

    OMIM gene information: 604503    OMIM disorders: --

    6 diseases for JMJD1C:    About MalaCards
    thyroiditis    fatty liver disease    liver disease    alzheimer's disease
    gastric cancer    cholesterol

    Human Genome Epidemiology (HuGE) Navigator: JMJD1C (6 documents)

    Export disorders for JMJD1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JMJD1C gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with JMJD1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    2. Identification and characterization of TRIP8 gene in silico. (PubMed id 14533015)1, 2, 9 Katoh M. and Katoh M. (2003)
    3. A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. (PubMed id 17353003)1, 2 Wolf S.S.... Obendorf M. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer. (PubMed id 17549425)1, 9 Katoh M. and Katoh M. (2007)
    7. Genome-wide association study indicates variants assoc iated with insulin signaling and inflammation mediate lipoprotein responses to f enofibrate. (PubMed id 22890011)1 Frazier-Wood A.C....Arnett D.K. (2012)
    8. Genome-wide association analysis of juvenile idiopathi c arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1 Thompson S.D....Glass D.N. (2012)
    9. A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid ho rmone regulation. (PubMed id 22829776)1 Coviello A.D....Perry J.R. (2012)
    10. A meta-analysis and genome-wide association study of p latelet count and mean platelet volume in african americans. (PubMed id 22423221)1 Qayyum R....Reiner A.P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221037 HGNC: 12313 AceView: JMJD1C Ensembl:ENSG00000171988 euGenes: HUgn221037
    ECgene: JMJD1C H-InvDB: JMJD1C

    (According to HUGE)
    About This Section
    HUGE: KIAA1380

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JMJD1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JMJD1C gene:
    Search GeneIP for patents involving JMJD1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of JMJD1C
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for JMJD1C   OriGene shRNA RFP for JMJD1C  
     Browse OriGene 29mer shRNA kits in GFP-retroviral vector   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JMJD1C  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for JMJD1C  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JMJD1C  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for JMJD1C   OriGene Custom Protein Services for JMJD1C  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JMJD1C
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JMJD1C
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD1C
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JMJD1C
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JMJD1C
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JMJD1C
     GenScript Custom Purified and Recombinant Proteins Services for JMJD1C GenScript cDNA clones with any tag delivered in your preferred vector for JMJD1C
     GenScript Custom Assay Services for JMJD1C GenScript Custom Superior Antibodies Services for JMJD1C
     GenScript Custom overexpressing Cell Line Services for JMJD1C CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in JMJD1C promoter
     Search Chromatin IP Primers for JMJD1C
     RT2 qPCR Primer Assay in human, mouse, rat JMJD1C
     Search GNC Networks for JMJD1C
     SABiosciences Custom PCR Arrays for JMJD1C
     Search Tocris compounds for JMJD1C
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     JMJD1C antibodies
     JMJD1C proteins
     Search for Antibodies for JMJD1C at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for JMJD1C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     JMJD1C Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for JMJD1C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JMJD1C
     SwitchGear 3'UTR luciferase reporter plasmids for JMJD1C
     SwitchGear Promoter luciferase reporter plasmids for JMJD1C
     ThermoFisher Antibodies for JMJD1C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JMJD1C
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      JMJD1C gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4