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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JMJD1C Gene

protein-coding   GIFtS: 61
GCID: GC10M064926

Jumonji Domain Containing 1C

(Previous name: thyroid hormone receptor interactor 8)
(Previous symbol: TRIP8)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Jumonji Domain Containing 1C1 2     RP11-10C13.22
TRIP81 2 3     Probable JmjC Domain-Containing Histone Demethylation Protein 2C2
Thyroid Hormone Receptor Interactor 81 2     Thyroid Receptor Interacting Protein 82
Jumonji Domain-Containing Protein 1C2 3     EC 1.14.11.-3
Thyroid Receptor-Interacting Protein 82 3     JHDM2C3
TRIP-82 3     KIAA13803
TR-Interacting Protein 82 3     EC 1.14.118

External Ids:    HGNC: 123131   Entrez Gene: 2210372   Ensembl: ENSG000001719887   OMIM: 6045035   UniProtKB: Q156523   

Export aliases for JMJD1C gene to outside databases

Previous GC identifers: GC10M064272 GC10M064597 GC10M058918


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for JMJD1C Gene: 
JMJD1C (jumonji domain containing 1C) is a protein-coding gene. Diseases associated with JMJD1C include thyroiditis, and fatty liver disease, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and thyroid hormone receptor binding. An important paralog of this gene is KDM3B.

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a
central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved
in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target
genes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JMJD1C gene promoter:
         Egr-3   E2F-3a   E2F-4   E2F-5   Nkx2-5   E2F-2   CREB   E2F-1   E2F   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJMJD1C promoter sequence
   Search SABiosciences Chromatin IP Primers for JMJD1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JMJD1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.3   Ensembl cytogenetic band:  10q21.3   HGNC cytogenetic band: 10q22.1

JMJD1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JMJD1C gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M064926:  view genomic region     (about GC identifiers)

Start:
64,926,981 bp from pter      End:
65,225,722 bp from pter
Size:
298,742 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652 (See protein sequence)
Recommended Name: Probable JmjC domain-containing histone demethylation protein 2C  
Size: 2540 amino acids; 284525 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts specifically with the ligand-binding domain of the thyroid receptor (TR). Requires the presence
of thyroid hormone for its interaction
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAC41741.1; Type=Frameshift; Positions=2171; Sequence=CAD97921.1; Type=Frameshift;
Positions=1697; Sequence=CAI10947.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for JMJD1C:
2YPD (3D)    
Secondary accessions: A0T124 Q5SQZ8 Q5SQZ9 Q5SR00 Q7Z3E7 Q8N3U0 Q96KB9 Q9P2G7
Alternative splicing: 3 isoforms:  Q15652-1   Q15652-2   Q15652-3   (May function as a tumor suppressor, reduced expression in breast cancer tumors)

Explore the universe of human proteins at neXtProt for JMJD1C: NX_Q15652

Explore proteomics data for JMJD1C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15652

  • 4/6 DME Specific Peptides for JMJD1C (Q15652) (see all 6)
     KCRECRL  GVREMCD  SPVFCRF  ECWKQGQP 

    JMJD1C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JMJD1C Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004232.2  NP_001269877.1  NP_116165.1  

    ENSEMBL proteins: 
     ENSP00000382204   ENSP00000335929   ENSP00000444682   ENSP00000384990   ENSP00000382195  
    Reactome Protein details: Q15652
    Human Recombinant Protein Products for JMJD1C: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for JMJD1C 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS7776974
    GO:0005654nucleoplasm TAS--

    JMJD1C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q15652

    ProtoNet protein and cluster: Q15652

    UniProtKB/Swiss-Prot: JHD2C_HUMAN, Q15652
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By
    similarity)
    Similarity: Belongs to the JHDM2 histone demethylase family
    Similarity: Contains 1 JmjC domain


    JMJD1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JHD2C_HUMAN, Q15652
    Function: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a
    central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved
    in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target
    genes (By similarity)

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17353003
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0046872metal ion binding IEA--
    GO:0046966thyroid hormone receptor binding TAS7776974
    GO:0051213dioxygenase activity IEA--
         
    JMJD1C for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Jmjd1c):
     skeleton 

    JMJD1C for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidJMJD1C 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for JMJD1C About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for JMJD1C
        Hemostasis
    Factors involved in megakaryocyte development and platelet production


    1         Kegg Pathway  (Kegg details for JMJD1C):
        Transcriptional misregulation in cancer


    JMJD1C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JMJD1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for JMJD1C (Q156521, 2, 3 ENSP000003822044) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-1224969,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    GADD45AP245222, 3MINT-8255879 I2D: score=2 
    NUDT21O438092, 3MINT-8264391 I2D: score=2 
    TK1P041832, 3MINT-8273609 I2D: score=2 
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS7776974
    GO:0007596blood coagulation TAS--
    GO:0016568chromatin modification IEA--

    JMJD1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JMJD1C (JHD2C)

    Search CenterWatch for drugs/clinical trials and news about JMJD1C / JHD2C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JMJD1C gene (3 alternative transcripts): 
    NM_004241.2  NM_001282948.1  NM_032776.2  

    Unigene Cluster for JMJD1C:

    Jumonji domain containing 1C
    Hs.413416  [show with all ESTs]
    Unigene Representative Sequence: NM_032776
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467356(uc001jmk.3) ENST00000399262(uc001jmn.3) ENST00000327520(uc001jmo.3)
    ENST00000497922 ENST00000490669 ENST00000483298 ENST00000469152 ENST00000489372
    ENST00000542921(uc009xpk.1) ENST00000402544(uc001jml.3 uc001jmm.3 uc010qiq.2 uc009xpj.2 uc001jmp.1)
    ENST00000399251(uc001jmr.1)

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    Additional mRNA sequence: 

    AB037801.1 AK024991.1 AK027280.1 AK056660.1 AK095584.1 AK123507.1 AK126040.1 AL831917.1 
    BC026268.1 BC037981.1 BC047331.1 BC065742.1 BC067238.1 BC108649.1 BC126403.1 BC143722.1 
    BX537954.1 EF068222.1 L40411.1 

    24 DOTS entries:

    DT.100760960  DT.100761829  DT.101984094  DT.95370939  DT.444405  DT.212378  DT.121260092  DT.92045498 
    DT.40233822  DT.87014691  DT.40302170  DT.110581  DT.121260224  DT.92428572  DT.95367093  DT.95370938 
    DT.95370942  DT.108299  DT.121260010  DT.91697647  DT.91789642  DT.92057715  DT.92443085  DT.40241652 

    24/232 AceView cDNA sequences (see all 232):

    N92632 AA621524 CK819566 BC037981 CR619190 CK819567 CF139140 CA442431 
    AI288250 CA313216 BC047331 CK429926 AA904622 BC026268 T32742 AA644371 
    CR607761 CF137402 AW029467 R20253 AL701177 CD673964 AA329131 AI467861 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for JMJD1C (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                      -     -                                                               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                                                                                                                                 

    ExUns: 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26a · 26b · 26c · 26d
    SP1:        -     -           -           -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for JMJD1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JMJD1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATAATCAG
    JMJD1C Expression
    About this image


    See JMJD1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JMJD1C

    SOURCE GeneReport for Unigene cluster: Hs.413416
        SABiosciences Custom PCR Arrays for JMJD1C
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for JMJD1C gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jmjd1c1 , 5 jumonji domain containing 1C1, 5 86.77(n)1
    86.65(a)1
      10 (34.85 cM)5
    1088291  NM_207221.21  NP_997104.21 
     670961255 
    chicken
    (Gallus gallus)
    Aves JMJD1C1 jumonji domain containing 1C 78.05(n)
    78.82(a)
      423655  NM_001199546.1  NP_001186475.1 
    lizard
    (Anolis carolinensis)
    Reptilia JMJD1C6
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343204.1(2381158-2505207)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.330452 Xenopus laevis transcribed sequence with weak similarity more 72.73(n)    BU916031.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jmjd1c1 jumonji domain containing 1C 61.52(n)
    61.78(a)
      558436  XM_681650.5  XP_686742.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta JHDM26
    JmjC domain-containing histone demethylase 2
    35(a)
    1 → many
    3R(5341731-5346660)


    ENSEMBL Gene Tree for JMJD1C (if available)
    TreeFam Gene Tree for JMJD1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JMJD1C gene
    KDM3B2  KDM3A2  HR2  
    3 SIMAP similar genes for JMJD1C using alignment to 4 protein entries:     JHD2C_HUMAN (see all proteins):
    KDM3B    KDM3A    JMJD1B

    JMJD1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5822 SNPs in JMJD1C are shown (see all 5822)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1927809041,2
    --64926501(+) TATAGA/GTAATT 2 -- int10--------
    rs1852111451,2
    --64926518(+) AAATGC/TCACAT 2 -- int10--------
    rs563787431,2
    C,F--64926536(+) ATTCAC/AATGAA 2 -- int15Minor allele frequency- A:0.17NA EA 246
    rs1900941091,2
    --64926544(+) GAAATA/GTAATT 2 -- int10--------
    rs2006720261,2
    C--64926685(+) CCACT-/TTTTC 
            
    TTTCT
    2 -- int10--------
    rs571263331,2
    C,F--64926719(+) AGAAGC/AAAGGC 2 -- int12Minor allele frequency- A:0.25WA CSA 4
    rs568084731,2
    C--64926722(+) GAAAGAAAG/-  
            
    GCTAT
    2 -- int11Minor allele frequency- -:0.00NA 2
    rs780333461,2
    C,F--64926827(+) AGCCAG/ACTATT 2 -- int11Minor allele frequency- A:0.01NA 120
    rs1464091561,2
    --64926979(+) GAAAAA/CGTCAA 2 -- int10--------
    rs1408243891,2
    --64927152(+) TATTTA/CGCTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for JMJD1C (64926981 - 65176981 bp, first 250kb of JMJD1C)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for JMJD1C:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2658212CNV Deletion23128226
    esv2665134CNV Deletion23128226
    esv2660838CNV Deletion23128226
    esv2677353CNV Deletion23128226
    nsv510223CNV Loss20534489
    nsv831892CNV Gain+Loss17160897


    Human Gene Mutation Database (HGMD): JMJD1C
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing JMJD1C
    DNA2.0 Custom Variant and Variant Library Synthesis for JMJD1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604503    OMIM disorders: --

    6 diseases for JMJD1C:    About MalaCards
    thyroiditis    fatty liver disease    liver disease    gastric cancer
    arthritis    alzheimer's disease


    JMJD1C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): JMJD1C
    Human Genome Epidemiology (HuGE) Navigator: JMJD1C (6 documents)

    Export disorders for JMJD1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JMJD1C gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with JMJD1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    2. Identification and characterization of TRIP8 gene in silico. (PubMed id 14533015)1, 2, 9 Katoh M. and Katoh M. (2003)
    3. Genome-wide association analysis of juvenile idiopathi c arthritis identifies a new susceptibility locus at chromosomal region 3q13. (PubMed id 22354554)1, 4 Thompson S.D....Glass D.N. (2012)
    4. A meta-analysis and genome-wide association study of p latelet count and mean platelet volume in african americans. (PubMed id 22423221)1, 4 Qayyum R....Reiner A.P. (2012)
    5. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    6. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    7. Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)1, 4 Johnson A.D....Becker L.C. (2010)
    8. PNPLA3 variants specifically confer increased risk fo r histologic nonalcoholic fatty liver disease but not metabolic disease. (PubMed id 20648472)1, 4 Speliotes E.K....Hirschhorn J.N. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221037 HGNC: 12313 AceView: JMJD1C Ensembl:ENSG00000171988 euGenes: HUgn221037
    ECgene: JMJD1C Kegg: 221037 H-InvDB: JMJD1C

    (According to HUGE)
    About This Section
    HUGE: KIAA1380

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JMJD1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JMJD1C gene:
    Search GeneIP for patents involving JMJD1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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