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Aliases &
Descriptions
for KDM3A
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| DKFZp686A24246 2 | | DKFZp686P07111 2 | | EC 1.14.11.- 3 | | JHDM2A 2, 3 | | JHMD2A 1, 2 | | JMJD1 2, 3 | | JMJD1A 2, 3 | | KIAA0742 1, 2, 3 | | OTTHUMP00000160707 2 | | TSGA 1, 2, 3 |
| | | Descriptions |
|---|
| JmjC domain-containing histone demethylation protein 2A 3 | | Jumonji domain-containing protein 1A 3 | | jumonji C domain-containing histone demethylase 2A 2 | | jumonji domain containing 1 1, 2 | | jumonji domain containing 1A 1, 2 | | lysine (K)-specific demethylase 3A 2 | | lysine-specific demethylase 3A 1 | | testis-specific protein A 2 |
|
| |
Search outside databases for aliases for KDM3A gene |
Summaries
for KDM3A(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for KDM3A:
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in
hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript
variants. [provided by RefSeq]
UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing
a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9'
residue, with a preference for dimethylated residue, while it has weak or no activity on
trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate.
Involved in hormone-dependent transcriptional activation, by participating in recruitment to
androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional
activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and
TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity
resistance through regulation of metabolic genes such as PPARA and UCP1 |
Genomic Location
for KDM3A
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2KDM3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P086521:
(about GC identifiers)
Start:
|
86,521,435 bp from pter |
End:
|
86,573,350 bp from pter |
Size:
|
51,916 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins
for KDM3A
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1 (See
protein sequence)Recommended Name: Lysine-specific demethylase 3A Size: 1321 amino acids; 147327 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear in round
spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct
foci which disappear in mature spermatozoa (By similarity)
Secondary accessions: Q53S72 Q68D47 Q68UT9 Q6N050 Q8IY08Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001140160.1 NP_060903.2
ENSEMBL proteins: ENSP00000386660 ENSP00000386516 ENSP00000323659
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for KDM3A:
Assays for KDM3A: | Protein
Domains/
Families
for KDM3A(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9Y4C1
ProtoNet protein and cluster: Q9Y4C1 UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1Domain: The JmjC domain and the C6-type zinc-finger are required for the demethylation activityDomain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear
receptors (By similarity)Similarity: Belongs to the JHDM2 histone demethylase familySimilarity: Contains 1 JmjC domain | Gene Function
for KDM3A
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018433
 Applied Biosystems Silencer® siRNAs for KDM3A
 Sigma-Aldrich siRNA for KDM3A
Sigma-Aldrich shRNA for KDM3A
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_018433
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018433
untagged cDNA clone in CMV expression vector: NM_018433
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_018433
UniProtKB/Swiss-Prot: KDM3A_HUMAN, Q9Y4C1Function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing
a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9'
residue, with a preference for dimethylated residue, while it has weak or no activity on
trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate.
Involved in hormone-dependent transcriptional activation, by participating in recruitment to
androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional
activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and
TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity
resistance through regulation of metabolic genes such as PPARA and UCP1Enzyme Number (IUBMB): EC 1.14.11.- 9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Kdm3a):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005506 | iron ion binding |
IMP | 16603237 | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- | | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
About this table | Pathways & Interactions
for KDM3A
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): About this table
|
Drugs & Compounds
for KDM3A(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for KDM3A
|
Transcripts
for KDM3A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018433
Sigma-Aldrich siRNA for KDM3A
Sigma-Aldrich shRNA for KDM3A
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_018433 REFSEQ mRNAs for KDM3A gene (2 alternative transcripts): NM_001146688.1 NM_018433.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018433
OriGene GFP tagged cDNA clone in CMV expression vector: NM_018433
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018433
untagged cDNA clone in CMV expression vector: NM_018433
Additional cDNA sequence: AB018285.2 AK074314.1 AK304276.1 BC038297.2 BX640698.1 BX647271.1 BX647752.1 BX648841.1 CR749581.1 16 DOTS entries: DT.95159942 DT.449251 DT.91760885 DT.99948816 DT.40288610 DT.95255426 DT.100787360 DT.120934032 DT.97846421 DT.95182295 DT.40112642 DT.75157816 DT.95159941 DT.95303371 DT.95330753 DT.99945375 24/210 AceView cDNA sequences (see all 210
):BM669534 AL832150 AW511889 BU679010 BM699317 BM693249 BM669172 CD674187 CA432703 BQ020341 BU684149 BX647752 BM720959 CK429407 AA360794 AI492066 BQ424139 AW969321 AK125045 AA480252 AI143634 BM678585 NM_018433 BM969680 Unigene Cluster for KDM3A: Lysine (K)-specific demethylase 3A Hs.557425 [show with all ESTs]Unigene Representative Sequence: NM_018433
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for KDM3A (see all 10
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | · | 27c | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for KDM3A
3 Ensembl transcripts including schematic representations: ENST00000409556
ENST00000409064
ENST00000312912
|
Expression
for KDM3A
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| KDM3A expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for KDM3A
1 / 2 5 probe-sets matching KDM3A gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CATCCTTAAA
SOURCE GeneReport for Unigene cluster: Hs.557425
|
Orthologs
for KDM3A
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for KDM3A gene from 5/8 species (see all 8
)
About this table Species with no ortholog for KDM3A
ENSEMBL Gene Tree for KDM3A | Paralogs
for KDM3A(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for KDM3A gene
- KDM3B2 JMJD1C2 HR2
|
SNPs/Variants
for KDM3A(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for KDM3A (up to first 250kb)
|
Disorders & Mutations
for KDM3A
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611512
|
Medical News
for KDM3A(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for KDM3A (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for KDM3A gene (see all 14
): |
Search for KDM3A
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KDM3A
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing KDM3A
(According to HUGE)
About This Section
| |
Specialized Databases showing KDM3A(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for KDM3A(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for KDM3A:
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| | |  | Search Tocris compounds for KDM3A |
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