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Aliases for JKAMP Gene

Aliases for JKAMP Gene

  • JNK1/MAPK8-Associated Membrane Protein 2 3 5
  • Jun N-Terminal Kinase 1-Associated Membrane Protein 2 3
  • Medulloblastoma Antigen MU-MB-50.4 3 4
  • C14orf100 3 4
  • JAMP 3 4
  • Chromosome 14 Open Reading Frame 100 2
  • JNK1-Associated Membrane Protein 4
  • JNK-Associated Membrane Protein 3
  • C24orf100 3
  • HSPC213 3
  • HSPC327 3
  • CDA06 3

External Ids for JKAMP Gene

Previous HGNC Symbols for JKAMP Gene

  • C14orf100

Previous GeneCards Identifiers for JKAMP Gene

  • GC14P059020
  • GC14P059952
  • GC14P040115

Summaries for JKAMP Gene

GeneCards Summary for JKAMP Gene

JKAMP (JNK1/MAPK8-Associated Membrane Protein) is a Protein Coding gene. Diseases associated with JKAMP include Medulloblastoma. Among its related pathways are Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for JKAMP Gene

  • May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Gene Wiki entry for JKAMP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JKAMP Gene

Genomics for JKAMP Gene

Regulatory Elements for JKAMP Gene

Enhancers for JKAMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G059481 1.7 FANTOM5 ENCODE dbSUPER 9.9 -0.5 -480 5.4 HDGF PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 L3HYPDH JKAMP RBM8B GPR135
GH14G059405 1.4 FANTOM5 Ensembl ENCODE 10.7 -77.3 -77257 2.6 ELF3 SOX13 TFAP4 JUN RAD21 TCF12 GATA4 GATA2 NCOR1 HNF4G L3HYPDH JKAMP RTN1 DAAM1 RBM8B GC14P059386 PIR32681
GH14G059563 0.7 ENCODE 20.3 +81.1 81083 3.2 PKNOX1 FEZF1 ZIC2 OSR2 ZFP69B PRDM6 ZNF692 ZNF341 GLIS1 SCRT2 L3HYPDH JKAMP RTN1 DAAM1 DHRS7 CCDC175 ENSG00000258782
GH14G059507 1 Ensembl ENCODE 11.5 +23.2 23243 1.2 GTF2F1 CTCF ESRRA CEBPG RAD21 GATA3 GATA2 SCRT2 ZNF143 SMC3 L3HYPDH CCDC175 JKAMP ENSG00000258782
GH14G059359 1.5 Ensembl ENCODE dbSUPER 6.4 -121.5 -121533 5.9 HDGF ATF1 SIN3A TCF12 GATA2 FOS ZHX2 JUNB REST TBX21 L3HYPDH DAAM1 JKAMP RTN1 GC14P059386 GC14P059252
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JKAMP on UCSC Golden Path with GeneCards custom track

Promoters for JKAMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069184 -143 3001 HDGF PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for JKAMP Gene

Chromosome:
14
Start:
59,484,443 bp from pter
End:
59,505,410 bp from pter
Size:
20,968 bases
Orientation:
Plus strand

Genomic View for JKAMP Gene

Genes around JKAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JKAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JKAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JKAMP Gene

Proteins for JKAMP Gene

  • Protein details for JKAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P055-JKAMP_HUMAN
    Recommended name:
    JNK1/MAPK8-associated membrane protein
    Protein Accession:
    Q9P055
    Secondary Accessions:
    • B4DP67
    • Q6FIB6
    • Q6IAJ2
    • Q7Z5D4
    • Q86SY6
    • Q9H0Q6
    • Q9H2W0
    • Q9HAH5
    • Q9P0R3

    Protein attributes for JKAMP Gene

    Size:
    326 amino acids
    Molecular mass:
    36751 Da
    Quaternary structure:
    • Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L (By similarity).
    Miscellaneous:
    • Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.
    SequenceCaution:
    • Sequence=AAF29005.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF36133.1; Type=Frameshift; Positions=105, 124; Evidence={ECO:0000305};

    Alternative splice isoforms for JKAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JKAMP Gene

Post-translational modifications for JKAMP Gene

  • Ubiquitinated by RNF5 via Lys-63-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).
  • Ubiquitination at posLast=1616
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for JKAMP Gene

Domains & Families for JKAMP Gene

Protein Domains for JKAMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JKAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JKAMP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for JKAMP Gene

Function for JKAMP Gene

Molecular function for JKAMP Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).

Gene Ontology (GO) - Molecular Function for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 19269966
genes like me logo Genes that share ontologies with JKAMP: view
genes like me logo Genes that share phenotypes with JKAMP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JKAMP Gene

Localization for JKAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for JKAMP Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JKAMP gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with JKAMP: view

Pathways & Interactions for JKAMP Gene

genes like me logo Genes that share pathways with JKAMP: view

Pathways by source for JKAMP Gene

Gene Ontology (GO) - Biological Process for JKAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 19269966
genes like me logo Genes that share ontologies with JKAMP: view

No data available for SIGNOR curated interactions for JKAMP Gene

Drugs & Compounds for JKAMP Gene

No Compound Related Data Available

Transcripts for JKAMP Gene

Unigene Clusters for JKAMP Gene

JNK1/MAPK8-associated membrane protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for JKAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - - -
SP10:

Relevant External Links for JKAMP Gene

GeneLoc Exon Structure for
JKAMP
ECgene alternative splicing isoforms for
JKAMP

Expression for JKAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JKAMP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JKAMP Gene



NURSA nuclear receptor signaling pathways regulating expression of JKAMP Gene:

JKAMP

SOURCE GeneReport for Unigene cluster for JKAMP Gene:

Hs.446850

Evidence on tissue expression from TISSUES for JKAMP Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with JKAMP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JKAMP Gene

Orthologs for JKAMP Gene

This gene was present in the common ancestor of animals.

Orthologs for JKAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JKAMP 34 35
  • 99.79 (n)
cow
(Bos Taurus)
Mammalia JAMP 35
  • 98 (a)
OneToOne
JKAMP 34
  • 92.98 (n)
dog
(Canis familiaris)
Mammalia JKAMP 34 35
  • 93.89 (n)
oppossum
(Monodelphis domestica)
Mammalia JKAMP 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JKAMP 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jkamp 34
  • 87.78 (n)
mouse
(Mus musculus)
Mammalia Jkamp 34 16 35
  • 87.57 (n)
4931417E11Rik 35
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves JKAMP 34 35
  • 76.13 (n)
lizard
(Anolis carolinensis)
Reptilia JKAMP 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jkamp 34
  • 72.67 (n)
Str.15301 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22554 34
zebrafish
(Danio rerio)
Actinopterygii jkamp 34 35
  • 71.74 (n)
zgc63678 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001461 34
  • 54.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2126 34 35
  • 50.88 (n)
worm
(Caenorhabditis elegans)
Secernentea jamp-1 34 35
  • 44.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for JKAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JKAMP Gene

ENSEMBL:
Gene Tree for JKAMP (if available)
TreeFam:
Gene Tree for JKAMP (if available)

Paralogs for JKAMP Gene

Pseudogenes.org Pseudogenes for JKAMP Gene

genes like me logo Genes that share paralogs with JKAMP: view

No data available for Paralogs for JKAMP Gene

Variants for JKAMP Gene

Sequence variations from dbSNP and Humsavar for JKAMP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000137923 -- 59,496,126(+) GTCTT(G/T)AACTC intron-variant
rs1000288459 -- 59,484,237(+) CGCCC(A/G)TGTGC nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000309126 -- 59,486,240(+) GTTCT(C/G)TCTGC intron-variant, upstream-variant-2KB
rs1000364153 -- 59,499,818(+) TGTTT(C/G)ATTTG intron-variant
rs1000515146 -- 59,503,947(+) CCAGA(A/G)TGGAT downstream-variant-500B, reference, missense, utr-variant-3-prime

Variation tolerance for JKAMP Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JKAMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JKAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for JKAMP Gene

Disorders for JKAMP Gene

MalaCards: The human disease database

(1) MalaCards diseases for JKAMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
medulloblastoma
  • medulloblastoma, desmoplastic
- elite association - COSMIC cancer census association via MalaCards
Search JKAMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for JKAMP

Genetic Association Database (GAD)
JKAMP
Human Genome Epidemiology (HuGE) Navigator
JKAMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JKAMP
genes like me logo Genes that share disorders with JKAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JKAMP Gene

Publications for JKAMP Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Regulation of endoplasmic reticulum-associated degradation by RNF5- dependent ubiquitination of JNK-associated membrane protein (JAMP). (PMID: 19269966) Tcherpakov M. … Ronai Z.A. (J. Biol. Chem. 2009) 2 3 64
  3. JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. (PMID: 16166642) Kadoya T. … Ronai Z. (Mol. Cell. Biol. 2005) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for JKAMP Gene

Sources for JKAMP Gene

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