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JDP2 Gene

protein-coding   GIFtS: 59
GCID: GC14P075894

Jun Dimerization Protein 2

  See JDP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Jun Dimerization Protein 21 2
Progesterone Receptor Co-Activator1 2
JUNDM22

External Ids:    HGNC: 175461   Entrez Gene: 1229532   Ensembl: ENSG000001400447   OMIM: 6086575   UniProtKB: Q8WYK23   

Export aliases for JDP2 gene to outside databases

Previous GC identifers: GC14P073410 GC14P069722 GC14P073884 GC14P073888 GC14P074964 GC14P056063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for JDP2 Gene:
JDP2 (Jun dimerization protein 2) is a protein-coding gene. Diseases associated with JDP2 include skeletal muscle neoplasm. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ATF3.

UniProtKB/Swiss-Prot: JDP2_HUMAN, Q8WYK2
Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of
proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis,
cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone
deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the
modification of histones and the assembly of chromatin

Gene Wiki entry for JDP2 (Jun dimerization protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JDP2 gene promoter:
         CP2   ARP-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJDP2 promoter sequence
   Search Chromatin IP Primers for JDP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JDP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

JDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JDP2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075894:  view genomic region     (about GC identifiers)

Start:
75,894,419 bp from pter      End:
75,940,814 bp from pter
Size:
46,396 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JDP2_HUMAN, Q8WYK2 (See protein sequence)
Recommended Name: Jun dimerization protein 2  
Size: 163 amino acids; 18704 Da
Subunit: Forms a homodimer or heterodimer with JUN, JUNB, JUND, CEBPG and ATF2 thereby inhibiting transactivation
by JUN, ATF2 and CEBPG (By similarity). Binds multiple DNA elements such as cAMP-response element (CRE) and TPA
response element (TRE) either as homodimer or heterodimer (By similarity). Interacts with IRF2BP1
Secondary accessions: J3KN58 O95430 Q9UIE4
Alternative splicing: 2 isoforms:  Q8WYK2-1   Q8WYK2-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for JDP2: NX_Q8WYK2

Explore proteomics data for JDP2 at MOPED

Post-translational modifications: 

  • Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives
    stress and anisomycin treatments1
  • Polyubiquitinated; probably by IRF2BP11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See JDP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128519.1  NP_001128520.1  NP_001128521.1  NP_569736.1  

    ENSEMBL proteins: 
     ENSP00000415558   ENSP00000452769   ENSP00000399587   ENSP00000267569   ENSP00000409787  

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    Cloud-Clone Corp. Proteins for JDP2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR000837 Leuzip_Fos

    Graphical View of Domain Structure for InterPro Entry Q8WYK2

    ProtoNet protein and cluster: Q8WYK2

    1 Blocks protein domain: IPB000837 Fos transforming protein signature

    UniProtKB/Swiss-Prot: JDP2_HUMAN, Q8WYK2
    Similarity: Belongs to the bZIP family. ATF subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with JDP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JDP2_HUMAN, Q8WYK2
    Function: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of
    proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis,
    cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone
    deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the
    modification of histones and the assembly of chromatin

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18671972
         
    Find genes that share ontologies with JDP2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for JDP2:
     Decreased viability with pacli  Increased S DNA content  Increased cell size  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Jdp2):
     adipose tissue  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     integument  limbs/digits/tail  normal  skeleton 

    Find genes that share phenotypes with JDP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for JDP2: Jdp2tm1Kmm Jdp2tm1Aki Jdp2tm1Kkyo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JDP2
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    hsa-miR-582-3p hsa-miR-3607-3p hsa-miR-139-5p hsa-miR-30d hsa-miR-3921 hsa-miR-218 hsa-miR-766 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidJDP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JDP2_HUMAN, Q8WYK2: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with JDP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JDP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    2ATF-2 transcription factor network
    ATF-2 transcription factor network


    1 BioSystems Pathway for JDP2
        ATF-2 transcription factor network


    1 PharmGKB Pathway for JDP2
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JDP2
    Interactions:

        GeneGlobe Interaction Network for JDP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JDP2 (Q8WYK21, 2, 3 ENSP000002675694) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000096171P266402, 3MINT-6699624 I2D: score=1 
    ENSG00000224264P266402, 3MINT-6699624 I2D: score=1 
    ENSG00000226589P266402, 3MINT-6699624 I2D: score=1 
    ENSG00000231116P266402, 3MINT-6699624 I2D: score=1 
    VARSP266402, 3MINT-6699624 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0031065positive regulation of histone deacetylation IEA--
    GO:0045599negative regulation of fat cell differentiation IEA--

    Find genes that share ontologies with JDP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JDP2

    1 HMDB Compound for JDP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    3 Novoseek inferred chemical compound relationships for JDP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 50.4 8 12225289 (2), 19553667 (1), 16199860 (1), 18463134 (1) (see all 5)
    12-o-tetradecanoylphorbol 13-acetate 41.2 3 15861394 (1), 12171923 (1)
    retinoic acid 22.1 8 14510502 (1), 12903123 (1)



    Find genes that share compounds with JDP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JDP2 gene (4 alternative transcripts): 
    NM_001135047.1  NM_001135048.1  NM_001135049.1  NM_130469.3  

    Unigene Cluster for JDP2:

    Jun dimerization protein 2
    Hs.196482  [show with all ESTs]
    Unigene Representative Sequence: NM_130469
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419727 ENST00000559773 ENST00000559060 ENST00000558068 ENST00000435893(uc010asj.3 uc010tvc.2 uc001xrq.3)
    ENST00000267569 ENST00000437176(uc010tvb.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate JDP2 (see all 62):
    hsa-miR-582-3p hsa-miR-3607-3p hsa-miR-139-5p hsa-miR-30d hsa-miR-3921 hsa-miR-218 hsa-miR-766 hsa-miR-548l
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      QuantiTect SYBR Green Assays in human, mouse, rat JDP2
      QuantiFast Probe-based Assays in human, mouse, rat JDP2

    Additional mRNA sequence: 

    AB077880.1 BC051303.1 BC068196.1 

    8 DOTS entries:

    DT.92023984  DT.100656624  DT.305197  DT.97798621  DT.440882  DT.120791880  DT.40118089  DT.91659877 

    Selected AceView cDNA sequences (see all 162):

    BM663816 BF739917 CB055142 BM692668 BU733974 BF940302 BE279642 BM855057 
    BE900522 BM665343 BF196731 BM727452 BX108645 CK430962 BU740697 BE219313 
    BX955347 AA443659 R47876 BQ008648 AK128851 BM692594 BC051303 BM702613 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JDP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTATAC
    JDP2 Expression
    About this image


    JDP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Autopod Long Bone
     
     Spleen (Hematopoietic System)
    JDP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JDP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.196482
        Custom PCR Arrays for JDP2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for JDP2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jdp21 , 5 Jun dimerization protein 21, 5 89.98(n)1
    96.32(a)1
      12 (39.74 cM)5
    817031  NM_030887.21  NP_112149.21 
     855991055 
    chicken
    (Gallus gallus)
    Aves JDP21 Jun dimerization protein 2 85.07(n)
    93.25(a)
      423363  NM_001277887.1  NP_001264816.1 
    lizard
    (Anolis carolinensis)
    Reptilia JDP26
    Jun dimerization protein 2
    76(a)
    1 ↔ 1
    1(22359222-22364877)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb12f112 Transcribed sequence with weak similarity to protein more 73.94(n)    57089120 


    ENSEMBL Gene Tree for JDP2 (if available)
    TreeFam Gene Tree for JDP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JDP2 gene
    ATF32  
    6 SIMAP similar genes for JDP2 using alignment to 2 protein entries:     JDP2_HUMAN (see all proteins):
    FOSL2    FOS    FOSB    BATF3    BATF    ATF3

    Find genes that share paralogs with JDP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JDP2 (see all 923)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998552851,2
    C--75892681(+) GGCTTC/TTCCCT 1 -- us2k10--------
    rs1434640651,2
    --75892784(+) CTATAA/TGAAAC 1 -- us2k10--------
    rs80043341,2
    C,F,A,H--75892896(+) TAACAT/CATTTA 1 -- us2k123Minor allele frequency- C:0.34NS EA NA WA CSA 2349
    rs1925579161,2
    --75892965(+) CAGGCC/TCTAGA 2 -- us2k10--------
    rs71447261,2
    C,F--75893122(+) ATGGGA/GGAAAC 3 -- us2k12Minor allele frequency- G:0.11NA WA 120
    rs1845177041,2
    --75893201(+) TGGGGC/TGAAGA 3 -- us2k10--------
    rs1467354631,2
    --75893285(+) TCTTAA/CCTGCC 3 -- us2k10--------
    rs1893152721,2
    --75893350(+) ATGTCA/CTTGGG 3 -- us2k10--------
    rs1819788411,2
    --75893576(+) TTCCTG/TTCTTC 3 -- us2k10--------
    rs1403279411,2
    --75893777(+) AGGGCA/TCCATG 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for JDP2 (75894419 - 75940814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for JDP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv22667CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JDP2
    DNA2.0 Custom Variant and Variant Library Synthesis for JDP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608657    OMIM disorders: --

    1 disease for JDP2:    
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    skeletal muscle neoplasm

    1 disease from the University of Copenhagen DISEASES database for JDP2:
    Skeletal muscle neoplasm

    Find genes that share disorders with JDP2           About GenesLikeMe

    Genetic Association Database (GAD): JDP2
    Human Genome Epidemiology (HuGE) Navigator: JDP2 (1 document)

    Export disorders for JDP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JDP2 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with JDP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. (PubMed id 16026868)1, 2, 9 Lerdrup M.... Kallunki T. (Biochim. Biophys. Acta 2005)
    2. Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1. (PubMed id 18307971)1, 2, 9 Murata T.... Yokoyama K.K. (Anal. Biochem. 2008)
    3. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PubMed id 18671972)1, 2, 9 Kimura M. (FEBS Lett. 2008)
    4. Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. (PubMed id 20452405)1, 4 Krischek B....Inoue I. (Neuroscience 2010)
    5. Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. (PubMed id 17545590)1, 3 Stewart M....Neil J.C. (Cancer Res. 2007)
    6. Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL. (PubMed id 12707301)1, 2 Kawaida R.... Furukawa H. (J. Exp. Med. 2003)
    7. JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. (PubMed id 12052888)1, 3 Jin C....Yokoyama K.K. (Mol. Cell. Biol. 2002)
    8. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. (PubMed id 9154808)1, 3 Aronheim A....Karin M. (Mol. Cell. Biol. 1997)
    9. The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase. (PubMed id 11602244)1, 9 Katz S....Aronheim A. (FEBS Lett. 2001)
    10. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension of the DNA binding domain. (PubMed id 19553667)1, 9 Hill K.K....Edwards D.P. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122953 HGNC: 17546 AceView: JDP2 Ensembl:ENSG00000140044 euGenes: HUgn122953
    ECgene: JDP2 H-InvDB: JDP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for JDP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for JDP2 gene:
    Search GeneIP for patents involving JDP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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