JDP2 Gene

Aliases
for JDP2 gene

Previous GC identifers: GC14P073410 GC14P069722 GC14P073884 GC14P073888 GC14P074964 GC14P056063

Summaries
for JDP2 gene

Genomic Views
for JDP2 gene

RefSeq DNA sequence:

NC_000014.8  NC_018925.1  NT_026437.12  

SwitchGear Promoter luciferase reporter plasmid: JDP2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JDP2

JDP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P075894:  view genomic region     (about GC identifiers)

Proteins
for JDP2 gene

Explore the universe of human proteins at neXtProt for JDP2: NX_Q8WYK2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): JDP2 OriGene Custom Protein Services for JDP2
	GenScript Custom Purified and Recombinant Proteins Services for JDP2
	Novus Biologicals JDP2 Proteins Novus Biologicals JDP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for JDP2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for JDP2
	GenScript Custom Superior Antibodies Services for JDP2
	Novus Biologicals JDP2 Antibodies
	Search for Antibodies for JDP2 at Abcam
	Uscn Antibodies for JDP2
	ThermoFisher Antibodies for JDP2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for JDP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for JDP2

Protein Domains /
Families
for JDP2 gene

ProtoNet protein and cluster: Q8WYK2

Function
for JDP2 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 4): JDP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JDP2
		8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate JDP2 (see all 62):
		hsa-miR-582-3p hsa-miR-3607-3p hsa-miR-139-5p hsa-miR-30d hsa-miR-3921 hsa-miR-218 hsa-miR-766 hsa-miR-548l
		SwitchGear 3'UTR luciferase reporter plasmid: JDP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JDP2 (see all 4) OriGene shRNA RFP: JDP2 OriGene siRNA: JDP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JDP2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for JDP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JDP2 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JDP2 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): JDP2 (NM_001135047)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JDP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JDP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for JDP2
		Search LifeMap BioReagents cell lines for JDP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JDP2

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 3 alleles) (MGI details for Jdp2)

Pathways & Interactions
for JDP2 gene

	Super-pathway	contained gene-specific pathways
1	ATF-2 transcription factor network	ATF-2 transcription factor network 1.00
2	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics 1.00

1 BioSystems Pathway for JDP2

ATF-2 transcription factor network

1 PharmGKB Pathway for JDP2

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for JDP2 gene

Transcripts
for JDP2 gene

Expression
for JDP2 gene

JDP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTTATAC

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BoneAutopod Long Bone			Bone
	BoneStylopod Long Bone			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JDP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JDP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JDP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JDP2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JDP2

Orthologs
for JDP2 gene

Paralogs
for JDP2 gene

Paralogs for JDP2 gene

FOSL1²  ATF3²  FOSB²  FOS²  FOSL2²  

6 SIMAP similar genes for JDP2 using alignment to 3 protein entries:     JDP2_HUMAN (see all proteins):

FOS    ATF3    FOSL2    BATF3    BATF    FOSB

JDP2 for paralogs           About GeneDecksing

Genomic Variants
for JDP2 gene

10/790 NCBI SNPs in JDP2 are shown (see all 790)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1998552851,2	C	--	75892681(+)	GGCTTC/TTCCCT	1	--	us2k1		0	--	--	--	--
rs1434640651,2		--	75892784(+)	CTATAA/TGAAAC	1	--	us2k1		0	--	--	--	--
rs80043341,2	C,F,A,H,	--	75892896(+)	TAACAT/CATTTA	1	--	us2k1		23		NS EA NA WA CSA	2349
rs1925579161,2		--	75892965(+)	CAGGCC/TCTAGA	2	--	us2k1		0	--	--	--	--
rs71447261,2	C,	--	75893122(+)	ATGGGA/GGAAAC	3	--	us2k1		2		NA WA	120
rs1845177041,2		--	75893201(+)	TGGGGC/TGAAGA	3	--	us2k1		0	--	--	--	--
rs1467354631,2		--	75893285(+)	TCTTAA/CCTGCC	3	--	us2k1		0	--	--	--	--
rs1893152721,2		--	75893350(+)	ATGTCA/CTTGGG	3	--	us2k1		0	--	--	--	--
rs1819788411,2		--	75893576(+)	TTCCTG/TTCTTC	3	--	us2k1		0	--	--	--	--
rs1403279411,2		--	75893777(+)	AGGGCA/TCCATG	3	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for JDP2 (75894419 - 75940814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for JDP2
     1 Indel: 71921

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JDP2

DNA2.0 Custom Variant and Variant Library Synthesis for JDP2

Disorders / Diseases
for JDP2 gene

Publications
for JDP2 gene

PubMed articles for JDP2 gene, integrated from 9 sources (see all 41): (articles sorted by number of sources associating them with JDP2)

Utopia: connect your pdf to the dynamic world of online information

1. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. (PubMed id 16026868)^{1, 2, 9} Lerdrup M.... Kallunki T. (2005)
2. Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in Escherichia coli by Jun N-terminal kinase 1. (PubMed id 18307971)^{1, 2, 9} Murata T.... Yokoyama K.K. (2008)
3. IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. (PubMed id 18671972)^{1, 2, 9} Kimura M. (2008)
4. Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. (PubMed id 17545590)^{1, 3} Stewart M....Neil J.C. (2007)
5. Jun dimerization protein 2 (JDP2), a member of the AP-1 family of transcription factor, mediates osteoclast differentiation induced by RANKL. (PubMed id 12707301)^{1, 2} Kawaida R.... Furukawa H. (2003)
6. JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells. (PubMed id 12052888)^{1, 3} Jin C....Yokoyama K.K. (2002)
7. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. (PubMed id 9154808)^{1, 3} Aronheim A....Karin M. (1997)
8. The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase. (PubMed id 11602244)^{1, 9} Katz S....Aronheim A. (2001)
9. A progesterone receptor co-activator (JDP2) mediates activity through interaction with residues in the carboxyl-terminal extension o f the DNA binding domain. (PubMed id 19553667)^{1, 9} Hill K.K....Edwards D.P. (2009)
10. Differential targeting of the stress mitogen-activated protein kinases to the c-Jun dimerization protein 2. (PubMed id 12225289)^{1, 9} Katz S. and Aronheim A. (2002)

External Searches for JDP2 gene

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Products
for JDP2 gene