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Aliases for JCHAIN Gene

Aliases for JCHAIN Gene

  • Joining Chain Of Multimeric IgA And IgM 2 3 4
  • Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu Polypeptides 2 3
  • IgJ Chain 2 3
  • J Chain 2 3
  • IGCJ 3 4
  • IGJ 3 4
  • Immunoglobulin J Chain 2
  • JCH 3

External Ids for JCHAIN Gene

Previous HGNC Symbols for JCHAIN Gene

  • IGJ

Summaries for JCHAIN Gene

GeneCards Summary for JCHAIN Gene

JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include renal artery obstruction. GO annotations related to this gene include protein homodimerization activity and antigen binding.

UniProtKB/Swiss-Prot for JCHAIN Gene

  • Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Wiki entry for JCHAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JCHAIN Gene

Genomics for JCHAIN Gene

Genomic Location for JCHAIN Gene

Chromosome:
4
Start:
70,655,541 bp from pter
End:
70,681,817 bp from pter
Size:
26,277 bases
Orientation:
Minus strand

Genomic View for JCHAIN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JCHAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JCHAIN Gene

No data available for Regulatory Elements for JCHAIN Gene

Proteins for JCHAIN Gene

  • Protein details for JCHAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01591-IGJ_HUMAN
    Recommended name:
    Immunoglobulin J chain
    Protein Accession:
    P01591

    Protein attributes for JCHAIN Gene

    Size:
    159 amino acids
    Molecular mass:
    18099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JCHAIN Gene

Proteomics data for JCHAIN Gene at MOPED

Post-translational modifications for JCHAIN Gene

  • Glycosylation at Asn 71
  • Modification sites at PhosphoSitePlus

Other Protein References for JCHAIN Gene

No data available for DME Specific Peptides for JCHAIN Gene

Domains & Families for JCHAIN Gene

Protein Domains for JCHAIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JCHAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JCHAIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for JCHAIN Gene

Function for JCHAIN Gene

Molecular function for JCHAIN Gene

UniProtKB/Swiss-Prot Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Ontology (GO) - Molecular Function for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 contributes_to single-stranded DNA binding IDA 21786026
GO:0003823 antigen binding NAS 2984306
GO:0019862 IgA binding IMP 17237408
GO:0031210 contributes_to phosphatidylcholine binding IDA 21786026
GO:0034987 contributes_to immunoglobulin receptor binding IMP 17237408
genes like me logo Genes that share ontologies with JCHAIN: view
genes like me logo Genes that share phenotypes with JCHAIN: view

Animal Models for JCHAIN Gene

MGI Knock Outs for JCHAIN:

miRNA for JCHAIN Gene

miRTarBase miRNAs that target JCHAIN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for JCHAIN Gene

Localization for JCHAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JCHAIN Gene

Secreted.

Gene Ontology (GO) - Cellular Components for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 2984306
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19199708
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
GO:0071750 dimeric IgA immunoglobulin complex IMP 17237408
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for Subcellular locations from COMPARTMENTS for JCHAIN Gene

Pathways & Interactions for JCHAIN Gene

SuperPathways for JCHAIN Gene

No Data Available

Interacting Proteins for JCHAIN Gene

Gene Ontology (GO) - Biological Process for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002250 adaptive immune response IDA 21786026
GO:0003094 glomerular filtration IMP 23398317
GO:0006955 immune response NAS 2984306
GO:0019731 antibacterial humoral response IDA 23250751
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for Pathways by source and SIGNOR curated interactions for JCHAIN Gene

Drugs & Compounds for JCHAIN Gene

No Compound Related Data Available

Transcripts for JCHAIN Gene

Alternative Splicing Database (ASD) splice patterns (SP) for JCHAIN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2:
SP3: -

Relevant External Links for JCHAIN Gene

GeneLoc Exon Structure for
JCHAIN
ECgene alternative splicing isoforms for
JCHAIN

Expression for JCHAIN Gene

mRNA expression in normal human tissues for JCHAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JCHAIN Gene

This gene is overexpressed in Milk (23.4) and Saliva (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for JCHAIN Gene



genes like me logo Genes that share expression patterns with JCHAIN: view

Protein tissue co-expression partners for JCHAIN Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JCHAIN Gene

Orthologs for JCHAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for JCHAIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGJ 35
  • 84.71 (n)
  • 77.71 (a)
IGJ 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGJ 35
  • 89.6 (n)
  • 83.44 (a)
IGJ 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igj 35
  • 82.49 (n)
  • 76.58 (a)
Igj 16
Igj 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGJ 35
  • 99.37 (n)
  • 98.74 (a)
IGJ 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGJ 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGJ 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGJ 35
  • 63.66 (n)
  • 56.77 (a)
IGJ 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGJ 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734759 35
  • 61.03 (n)
  • 54.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.261 35
Species with no ortholog for JCHAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JCHAIN Gene

ENSEMBL:
Gene Tree for JCHAIN (if available)
TreeFam:
Gene Tree for JCHAIN (if available)

Paralogs for JCHAIN Gene

Pseudogenes.org Pseudogenes for JCHAIN Gene

genes like me logo Genes that share paralogs with JCHAIN: view

No data available for Paralogs for JCHAIN Gene

Variants for JCHAIN Gene

Variation tolerance for JCHAIN Gene

Residual Variation Intolerance Score: 61.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JCHAIN Gene

HapMap Linkage Disequilibrium report
JCHAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for JCHAIN Gene

Disorders for JCHAIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for JCHAIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal artery obstruction
- elite association

Relevant External Links for JCHAIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JCHAIN
genes like me logo Genes that share disorders with JCHAIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JCHAIN Gene

Publications for JCHAIN Gene

  1. Histogenomics: association of gene expression patterns with histological parameters in kidney biopsies. (PMID: 19155987) Perco P. … Oberbauer R. (Transplantation 2009) 23 67
  2. The promoter of the Immunoglobulin J Chain gene receives its authentic enhancer activity through the abutting MEF2 and PU.1 sites in a DNA-looping interaction. (PMID: 19467243) Lim J.H. … Kang C.J. (J. Mol. Biol. 2009) 23 67
  3. TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. (PMID: 18948302) North C.M. … Kaminski N.E. (Toxicol. Sci. 2009) 23 67
  4. Alterations in the human lung proteome with lipopolysaccharide. (PMID: 19432985) Bowler R.P. … Abraham E. (BMC Pulm Med 2009) 23 67
  5. Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PMID: 19714880) Lei Z. … Serra H.M. (J. Proteome Res. 2009) 23 67

Products for JCHAIN Gene

Sources for JCHAIN Gene

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