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Aliases for JCHAIN Gene

Aliases for JCHAIN Gene

  • Joining Chain Of Multimeric IgA And IgM 2 3 4 5
  • Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu Polypeptides 2 3
  • IgJ Chain 2 3
  • J Chain 2 3
  • IGCJ 3 4
  • IGJ 3 4
  • Immunoglobulin J Chain 2
  • JCH 3

External Ids for JCHAIN Gene

Previous HGNC Symbols for JCHAIN Gene

  • IGJ

Summaries for JCHAIN Gene

GeneCards Summary for JCHAIN Gene

JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include Renal Artery Obstruction. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Vesicle-mediated transport. GO annotations related to this gene include protein homodimerization activity and antigen binding.

UniProtKB/Swiss-Prot for JCHAIN Gene

  • Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Wiki entry for JCHAIN Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JCHAIN Gene

Genomics for JCHAIN Gene

Regulatory Elements for JCHAIN Gene

Enhancers for JCHAIN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JCHAIN on UCSC Golden Path with GeneCards custom track

Genomic Location for JCHAIN Gene

Chromosome:
4
Start:
70,655,541 bp from pter
End:
70,681,817 bp from pter
Size:
26,277 bases
Orientation:
Minus strand

Genomic View for JCHAIN Gene

Genes around JCHAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JCHAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JCHAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JCHAIN Gene

Proteins for JCHAIN Gene

  • Protein details for JCHAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01591-IGJ_HUMAN
    Recommended name:
    Immunoglobulin J chain
    Protein Accession:
    P01591

    Protein attributes for JCHAIN Gene

    Size:
    159 amino acids
    Molecular mass:
    18099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JCHAIN Gene

Proteomics data for JCHAIN Gene at MOPED

Post-translational modifications for JCHAIN Gene

  • Glycosylation at Asn 71
  • Modification sites at PhosphoSitePlus

Other Protein References for JCHAIN Gene

No data available for DME Specific Peptides for JCHAIN Gene

Domains & Families for JCHAIN Gene

Protein Domains for JCHAIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JCHAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JCHAIN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for JCHAIN Gene

Function for JCHAIN Gene

Molecular function for JCHAIN Gene

UniProtKB/Swiss-Prot Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Ontology (GO) - Molecular Function for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 2984306
GO:0031210 contributes_to phosphatidylcholine binding IDA 21786026
genes like me logo Genes that share ontologies with JCHAIN: view
genes like me logo Genes that share phenotypes with JCHAIN: view

Animal Models for JCHAIN Gene

MGI Knock Outs for JCHAIN:

Animal Model Products

miRNA for JCHAIN Gene

miRTarBase miRNAs that target JCHAIN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JCHAIN Gene

Localization for JCHAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JCHAIN Gene

Secreted.

Gene Ontology (GO) - Cellular Components for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071751 secretory IgA immunoglobulin complex IDA 23250751
GO:0071752 secretory dimeric IgA immunoglobulin complex IDA 24145934
GO:0071756 pentameric IgM immunoglobulin complex IDA 21786026
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for Subcellular locations from COMPARTMENTS for JCHAIN Gene

Pathways & Interactions for JCHAIN Gene

genes like me logo Genes that share pathways with JCHAIN: view

Pathways by source for JCHAIN Gene

Interacting Proteins for JCHAIN Gene

Gene Ontology (GO) - Biological Process for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IDA 21786026
GO:0003094 glomerular filtration IMP 23398317
GO:0006955 immune response NAS 2984306
GO:0032461 positive regulation of protein oligomerization IMP 17237408
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for SIGNOR curated interactions for JCHAIN Gene

Drugs & Compounds for JCHAIN Gene

No Compound Related Data Available

Transcripts for JCHAIN Gene

Alternative Splicing Database (ASD) splice patterns (SP) for JCHAIN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2:
SP3: -

Relevant External Links for JCHAIN Gene

GeneLoc Exon Structure for
JCHAIN
ECgene alternative splicing isoforms for
JCHAIN

Expression for JCHAIN Gene

mRNA expression in normal human tissues for JCHAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JCHAIN Gene

This gene is overexpressed in Milk (23.4) and Saliva (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JCHAIN Gene



genes like me logo Genes that share expression patterns with JCHAIN: view

Protein tissue co-expression partners for JCHAIN Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for JCHAIN Gene

Orthologs for JCHAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for JCHAIN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IGJ 35
  • 84.71 (n)
  • 77.71 (a)
IGJ 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGJ 35
  • 89.6 (n)
  • 83.44 (a)
IGJ 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Igj 35
  • 82.49 (n)
  • 76.58 (a)
Jchain 16
Igj 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IGJ 35
  • 99.37 (n)
  • 98.74 (a)
IGJ 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGJ 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGJ 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGJ 35
  • 63.66 (n)
  • 56.77 (a)
IGJ 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGJ 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734759 35
  • 61.03 (n)
  • 54.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.261 35
Species with no ortholog for JCHAIN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JCHAIN Gene

ENSEMBL:
Gene Tree for JCHAIN (if available)
TreeFam:
Gene Tree for JCHAIN (if available)

Paralogs for JCHAIN Gene

Pseudogenes.org Pseudogenes for JCHAIN Gene

genes like me logo Genes that share paralogs with JCHAIN: view

No data available for Paralogs for JCHAIN Gene

Variants for JCHAIN Gene

Sequence variations from dbSNP and Humsavar for JCHAIN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1050023 -- 70,655,879(-) GTTTC(A/C)CTGTG utr-variant-3-prime
rs1050039 -- 70,655,574(-) CTAGC(A/C)CAGTC utr-variant-3-prime
rs1061809 -- 70,655,075(-) AGATA(A/C)ATCCA downstream-variant-500B
rs2288243 -- 70,655,395(-) GGTGG(C/G)TTTGC downstream-variant-500B
rs2303411 -- 70,656,816(-) AGTTG(A/G)GAATA intron-variant

Variation tolerance for JCHAIN Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for JCHAIN Gene

Disorders for JCHAIN Gene

MalaCards: The human disease database

(1) MalaCards diseases for JCHAIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
renal artery obstruction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for JCHAIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JCHAIN
genes like me logo Genes that share disorders with JCHAIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JCHAIN Gene

Publications for JCHAIN Gene

  1. Human J chain gene. Structure and expression in B lymphoid cells. (PMID: 2984306) Max E.E. … Korsmeyer S.J. (J. Exp. Med. 1985) 2 3 4 67
  2. Human J chain gene: chromosomal localization and associated restriction fragment length polymorphisms. (PMID: 3016707) Max E.E. … Robinson M.A. (Proc. Natl. Acad. Sci. U.S.A. 1986) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Expression and glycoengineering of functionally active heteromultimeric IgM in plants. (PMID: 24706782) Loos A. … Steinkellner H. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. Human plasma-derived polymeric IgA and IgM antibodies associate with secretory component to yield biologically active secretory-like antibodies. (PMID: 23250751) Longet S. … CorthAcsy B. (J. Biol. Chem. 2013) 3

Products for JCHAIN Gene

Sources for JCHAIN Gene

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