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Aliases for JCHAIN Gene

Aliases for JCHAIN Gene

  • Joining Chain Of Multimeric IgA And IgM 2 3 4 5
  • Immunoglobulin J Polypeptide, Linker Protein For Immunoglobulin Alpha And Mu Polypeptides 2 3
  • Immunoglobulin J Chain 2 3
  • IgJ Chain 2 3
  • J Chain 2 3
  • IGCJ 3 4
  • IGJ 3 4
  • JCH 3

External Ids for JCHAIN Gene

Previous HGNC Symbols for JCHAIN Gene

  • IGJ

Summaries for JCHAIN Gene

GeneCards Summary for JCHAIN Gene

JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include Alpha Chain Disease and Mu Chain Disease. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein homodimerization activity and antigen binding.

UniProtKB/Swiss-Prot for JCHAIN Gene

  • Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Wiki entry for JCHAIN Gene

Additional gene information for JCHAIN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JCHAIN Gene

Genomics for JCHAIN Gene

Regulatory Elements for JCHAIN Gene

Enhancers for JCHAIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H070733 1.4 Ensembl ENCODE dbSUPER 11.2 -53.9 -53865 4 PKNOX1 BATF RAD21 RARA YY1 EGR1 SCRT2 ATF7 ETV6 RUNX3 RUFY3 RNU6-784P RNU6-520P UTP3 JCHAIN PIR34937 ENSG00000272986
GH04H070901 1.5 FANTOM5 ENCODE 10.3 -221.2 -221217 3 HNRNPUL1 PKNOX1 ARNT ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF2 YY1 MOB1B DCK GRSF1 UTP3 JCHAIN
GH04H070836 1.1 ENCODE 10.1 -156.9 -156917 3 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FOS UTP3 JCHAIN RUFY3 DCK GC04P070840 PIR34937
GH04H071003 1 Ensembl ENCODE 11 -323.8 -323784 4 CTCF PKNOX1 RAD21 RELA EED ATF7 RUNX3 IKZF2 CREM DPF2 UTP3 JCHAIN DCK RUFY3 GC04M071034
GH04H070721 0.9 ENCODE 11.4 -40.5 -40457 1 PKNOX1 ATF1 ZSCAN4 ZNF76 ZEB1 YY1 GATA2 EGR1 ZNF366 ZSCAN5C RUFY3 UTP3 JCHAIN ENSG00000272986 PIR34937
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JCHAIN on UCSC Golden Path with GeneCards custom track

Genomic Location for JCHAIN Gene

Chromosome:
4
Start:
70,655,541 bp from pter
End:
70,681,817 bp from pter
Size:
26,277 bases
Orientation:
Minus strand

Genomic View for JCHAIN Gene

Genes around JCHAIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JCHAIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JCHAIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JCHAIN Gene

Proteins for JCHAIN Gene

  • Protein details for JCHAIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01591-IGJ_HUMAN
    Recommended name:
    Immunoglobulin J chain
    Protein Accession:
    P01591

    Protein attributes for JCHAIN Gene

    Size:
    159 amino acids
    Molecular mass:
    18099 Da
    Quaternary structure:
    No Data Available

neXtProt entry for JCHAIN Gene

Post-translational modifications for JCHAIN Gene

  • Glycosylation at posLast=7171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for JCHAIN Gene

Domains & Families for JCHAIN Gene

Gene Families for JCHAIN Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for JCHAIN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JCHAIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with JCHAIN: view

No data available for UniProtKB/Swiss-Prot for JCHAIN Gene

Function for JCHAIN Gene

Molecular function for JCHAIN Gene

UniProtKB/Swiss-Prot Function:
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Gene Ontology (GO) - Molecular Function for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 contributes_to single-stranded DNA binding IDA 21786026
GO:0003823 antigen binding NAS 2984306
GO:0019862 IgA binding IMP 17237408
GO:0030674 protein binding, bridging IEA --
GO:0031210 contributes_to phosphatidylcholine binding IDA 21786026
genes like me logo Genes that share ontologies with JCHAIN: view
genes like me logo Genes that share phenotypes with JCHAIN: view

Animal Models for JCHAIN Gene

MGI Knock Outs for JCHAIN:

Animal Model Products

CRISPR Products

miRNA for JCHAIN Gene

miRTarBase miRNAs that target JCHAIN

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for JCHAIN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JCHAIN Gene

Localization for JCHAIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for JCHAIN Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JCHAIN gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 19199708
GO:0071748 monomeric IgA immunoglobulin complex IDA 23250751
GO:0071750 dimeric IgA immunoglobulin complex IMP 17237408
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for JCHAIN Gene

Pathways & Interactions for JCHAIN Gene

genes like me logo Genes that share pathways with JCHAIN: view

Gene Ontology (GO) - Biological Process for JCHAIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002250 adaptive immune response IDA 21786026
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006955 immune response NAS 2984306
genes like me logo Genes that share ontologies with JCHAIN: view

No data available for SIGNOR curated interactions for JCHAIN Gene

Drugs & Compounds for JCHAIN Gene

(1) Drugs for JCHAIN Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma Target 2359
genes like me logo Genes that share compounds with JCHAIN: view

Transcripts for JCHAIN Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for JCHAIN
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for JCHAIN Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2:
SP3: -

Relevant External Links for JCHAIN Gene

GeneLoc Exon Structure for
JCHAIN
ECgene alternative splicing isoforms for
JCHAIN

Expression for JCHAIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JCHAIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JCHAIN Gene

This gene is overexpressed in Milk (23.4) and Saliva (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JCHAIN Gene



Protein tissue co-expression partners for JCHAIN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JCHAIN Gene:

JCHAIN

Evidence on tissue expression from TISSUES for JCHAIN Gene

  • Intestine(5)
  • Bone marrow(4.6)
  • Liver(4.5)
  • Lung(4.3)
  • Saliva(4.3)
  • Stomach(3.9)
  • Lymph node(3.3)
  • Spleen(3.2)
  • Blood(3)
  • Gall bladder(2.4)
  • Kidney(2.4)
genes like me logo Genes that share expression patterns with JCHAIN: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for JCHAIN Gene

Orthologs for JCHAIN Gene

This gene was present in the common ancestor of chordates.

Orthologs for JCHAIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGJ 34 33
  • 99.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGJ 34 33
  • 89.6 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGJ 34 33
  • 84.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Igj 34 33
  • 82.49 (n)
OneToOne
Jchain 16
oppossum
(Monodelphis domestica)
Mammalia IGJ 34
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGJ 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGJ 34 33
  • 63.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGJ 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734759 33
  • 61.03 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.261 33
Species where no ortholog for JCHAIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JCHAIN Gene

ENSEMBL:
Gene Tree for JCHAIN (if available)
TreeFam:
Gene Tree for JCHAIN (if available)

Paralogs for JCHAIN Gene

Pseudogenes.org Pseudogenes for JCHAIN Gene

genes like me logo Genes that share paralogs with JCHAIN: view

No data available for Paralogs for JCHAIN Gene

Variants for JCHAIN Gene

Sequence variations from dbSNP and Humsavar for JCHAIN Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002352 -- 70,674,861(+) TCTAT(C/T)TTAAT intron-variant
rs1000552678 -- 70,660,106(+) ACACT(C/G)TTCAA intron-variant
rs1000618997 -- 70,664,161(+) GGTGG(A/C/G)GGTTG intron-variant
rs1000694371 -- 70,664,006(+) GGTGG(A/G)TCATG intron-variant
rs1000882902 -- 70,664,792(+) GACTA(C/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JCHAIN Gene

Variant ID Type Subtype PubMed ID
nsv1012495 CNV gain 25217958
nsv1123807 CNV deletion 24896259
nsv829965 CNV gain 17160897

Variation tolerance for JCHAIN Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.36; 41.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JCHAIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JCHAIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JCHAIN Gene

Disorders for JCHAIN Gene

MalaCards: The human disease database

(3) MalaCards diseases for JCHAIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
alpha chain disease
  • seligmann's disease
mu chain disease
  • mu-chain disease
renal artery obstruction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for JCHAIN

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JCHAIN
genes like me logo Genes that share disorders with JCHAIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JCHAIN Gene

Publications for JCHAIN Gene

  1. Human J chain gene. Structure and expression in B lymphoid cells. (PMID: 2984306) Max EE … Korsmeyer SJ (The Journal of experimental medicine 1985) 2 3 4 60
  2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4 60
  3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 60
  4. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen TZ … Pandey A (Molecular & cellular proteomics : MCP 2004) 3 4 60
  5. Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. (PMID: 1472500) Frutiger S … Jaton JC (Biochemistry 1992) 3 4 60

Products for JCHAIN Gene

Sources for JCHAIN Gene

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