Aliases for JAZF1 Gene
External Ids for JAZF1 Gene
Previous GeneCards Identifiers for JAZF1 Gene
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
GeneCards Summary for JAZF1 Gene
JAZF1 (JAZF Zinc Finger 1) is a Protein Coding gene. Diseases associated with JAZF1 include Endometrial Stromal Sarcoma and Endometrial Stromal Nodule. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription corepressor activity.
UniProtKB/Swiss-Prot for JAZF1 Gene
Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By similarity).