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Aliases for JAZF1 Gene

Aliases for JAZF1 Gene

  • JAZF Zinc Finger 1 2 3
  • TIP27 3 4 6
  • TAK1-Interacting Protein 27 3 4
  • Zinc Finger Protein 802 3 4
  • ZNF802 3 4
  • Juxtaposed With Another Zinc Finger Protein 1 3
  • Juxtaposed With Another Zinc Finger Gene 1 3

External Ids for JAZF1 Gene

Previous GeneCards Identifiers for JAZF1 Gene

  • GC07U990333
  • GC07M027578
  • GC07M027612
  • GC07M027595
  • GC07M027643
  • GC07M027837
  • GC07M027752

Summaries for JAZF1 Gene

Entrez Gene Summary for JAZF1 Gene

  • This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

GeneCards Summary for JAZF1 Gene

JAZF1 (JAZF Zinc Finger 1) is a Protein Coding gene. Diseases associated with JAZF1 include endometrial stromal tumor. GO annotations related to this gene include nucleic acid binding and transcription corepressor activity.

UniProtKB/Swiss-Prot for JAZF1 Gene

  • Potential transcription factor

Gene Wiki entry for JAZF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAZF1 Gene

Genomics for JAZF1 Gene

Regulatory Elements for JAZF1 Gene

Genomic Location for JAZF1 Gene

Start:
27,830,573 bp from pter
End:
28,180,818 bp from pter
Size:
350,246 bases
Orientation:
Minus strand

Genomic View for JAZF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JAZF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAZF1 Gene

Proteins for JAZF1 Gene

  • Protein details for JAZF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ6-JAZF1_HUMAN
    Recommended name:
    Juxtaposed with another zinc finger protein 1
    Protein Accession:
    Q86VZ6
    Secondary Accessions:
    • A4D195
    • Q8N3L7

    Protein attributes for JAZF1 Gene

    Size:
    243 amino acids
    Molecular mass:
    27079 Da
    Quaternary structure:
    • Interacts with TAK1
    Miscellaneous:
    • Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and high levels of progesterone (PubMed:18772439).

    Alternative splice isoforms for JAZF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAZF1 Gene

Proteomics data for JAZF1 Gene at MOPED

Post-translational modifications for JAZF1 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

Other Protein References for JAZF1 Gene

No data available for DME Specific Peptides for JAZF1 Gene

Domains for JAZF1 Gene

Gene Families for JAZF1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for JAZF1 Gene

Suggested Antigen Peptide Sequences for JAZF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VZ6

UniProtKB/Swiss-Prot:

JAZF1_HUMAN :
  • Q86VZ6
Similarity:
  • Contains 3 C2H2-type zinc fingers.
genes like me logo Genes that share domains with JAZF1: view

Function for JAZF1 Gene

Molecular function for JAZF1 Gene

UniProtKB/Swiss-Prot Function: Potential transcription factor

Gene Ontology (GO) - Molecular Function for JAZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity IDA 15302918
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with JAZF1: view

Phenotypes for JAZF1 Gene

GenomeRNAi human phenotypes for JAZF1:
genes like me logo Genes that share phenotypes with JAZF1: view

miRNA for JAZF1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for JAZF1 Gene

Localization for JAZF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAZF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JAZF1 Gene COMPARTMENTS Subcellular localization image for JAZF1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for JAZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0017053 transcriptional repressor complex IDA 15302918
genes like me logo Genes that share ontologies with JAZF1: view

Pathways for JAZF1 Gene

SuperPathways for JAZF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JAZF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15302918
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with JAZF1: view

No data available for Pathways by source for JAZF1 Gene

Transcripts for JAZF1 Gene

Unigene Clusters for JAZF1 Gene

JAZF zinc finger 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JAZF1 Gene

No ASD Table

Relevant External Links for JAZF1 Gene

GeneLoc Exon Structure for
JAZF1
ECgene alternative splicing isoforms for
JAZF1

Expression for JAZF1 Gene

mRNA expression in normal human tissues for JAZF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JAZF1 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JAZF1 Gene

SOURCE GeneReport for Unigene cluster for JAZF1 Gene Hs.368944

genes like me logo Genes that share expressions with JAZF1: view

No data available for mRNA Expression by UniProt/SwissProt for JAZF1 Gene

Orthologs for JAZF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for JAZF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAZF1 35
  • 99.73 (n)
  • 100 (a)
JAZF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JAZF1 35
  • 94.92 (n)
  • 100 (a)
JAZF1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAZF1 35
  • 94.96 (n)
  • 99.51 (a)
JAZF1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jazf1 35
  • 92.32 (n)
  • 99.59 (a)
Jazf1 16
Jazf1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JAZF1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JAZF1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jazf1 35
  • 93.42 (n)
  • 99.59 (a)
chicken
(Gallus gallus)
Aves JAZF1 35
  • 87.38 (n)
  • 98.35 (a)
JAZF1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JAZF1 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jazf1 35
  • 84.64 (n)
  • 97.53 (a)
Str.13177 35
zebrafish
(Danio rerio)
Actinopterygii jazf1a 35
  • 76.19 (n)
  • 86.15 (a)
jazf1a 36
  • 69 (a)
OneToMany
jazf1b 36
  • 90 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12054 35
  • 59.9 (n)
  • 57.97 (a)
CG12054 36
  • 19 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SFP1 36
  • 9 (a)
OneToOne
Species with no ortholog for JAZF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAZF1 Gene

ENSEMBL:
Gene Tree for JAZF1 (if available)
TreeFam:
Gene Tree for JAZF1 (if available)

Paralogs for JAZF1 Gene

Selected SIMAP similar genes for JAZF1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with JAZF1: view

No data available for Paralogs for JAZF1 Gene

Variants for JAZF1 Gene

Sequence variations from dbSNP and Humsavar for JAZF1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs188 -- 27,897,118(+) AACTA(G/T)CATGG intron-variant
rs189 -- 27,899,906(+) ACAGT(G/T)GAAAG intron-variant
rs190 -- 27,897,001(+) TTCTA(C/T)TGTCC intron-variant
rs191 -- 27,901,650(+) GTGTG(A/G)TGTGG intron-variant
rs192 -- 27,904,060(+) AAGGA(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAZF1 Gene

Variant ID Type Subtype PubMed ID
dgv2072e1 CNV Complex 17122850
nsv5677 CNV Loss 18451855
esv24518 CNV Loss 19812545
esv2658930 CNV Deletion 23128226
nsv520555 CNV Loss 19592680
esv269333 CNV Insertion 20981092
nsv830931 CNV Gain 17160897
esv2461042 CNV Deletion 19546169
esv1940109 CNV Deletion 18987734
esv2734174 CNV Deletion 23290073
esv2665878 CNV Deletion 23128226
esv1002613 CNV Deletion 20482838
esv1128518 CNV Deletion 17803354

Relevant External Links for JAZF1 Gene

HapMap Linkage Disequilibrium report
JAZF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAZF1 Gene

Disorders for JAZF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for JAZF1 Gene including...

Search for JAZF1 Gene in MalaCards »

UniProtKB/Swiss-Prot

JAZF1_HUMAN
  • Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1. {ECO:0000269 PubMed:11371647, ECO:0000269 PubMed:16397222}.

(1) University of Copenhagen DISEASES for JAZF1 Gene

Relevant External Links for JAZF1

Genetic Association Database (GAD)
JAZF1
Human Genome Epidemiology (HuGE) Navigator
JAZF1
genes like me logo Genes that share disorders with JAZF1: view

Publications for JAZF1 Gene

  1. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PMID: 11371647) Koontz J.I. … Sklar J. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23
  2. A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. (PMID: 18772439) Li H. … Sklar J. (Science 2008) 3 4 23
  3. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. (PMID: 8401585) Adams M.D. … Venter J.C. (Nat. Genet. 1993) 2 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for JAZF1 Gene

Sources for JAZF1 Gene

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