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JAZF1 Gene

protein-coding   GIFtS: 52
GCID: GC07M027837

JAZF Zinc Finger 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
JAZF Zinc Finger 11 2     TAK1-Interacting Protein 272 3
TIP272 3 5     Juxtaposed With Another Zinc Finger Gene 12
Zinc Finger Protein 8022 3     Juxtaposed With Another Zinc Finger Protein 12
ZNF8022 3     

External Ids:    HGNC: 289171   Entrez Gene: 2218952   Ensembl: ENSG000001538147   OMIM: 6062465   UniProtKB: Q86VZ63   

Export aliases for JAZF1 gene to outside databases

Previous GC identifers: GC07U990333 GC07M027578 GC07M027612 GC07M027595 GC07M027643 GC07M027752


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JAZF1 Gene:
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional
repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors.
Alternatively spliced variants which encode different protein isoforms have been described; however, not all
variants have been fully characterized (provided by RefSeq, Jul 2008)

GeneCards Summary for JAZF1 Gene:
JAZF1 (JAZF zinc finger 1) is a protein-coding gene. Diseases associated with JAZF1 include endometrial stromal tumor, and endometrial stromal sarcoma. GO annotations related to this gene include transcription corepressor activity and nucleic acid binding.

UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
Function: Potential transcription factor

Gene Wiki entry for JAZF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JAZF1 gene promoter:
         AML1a   Pbx1a   HOXA3   MyoD   Nkx2-5   Tal-1beta   E47   E2F-1   E2F   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJAZF1 promoter sequence
   Search Chromatin IP Primers for JAZF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAZF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2-p15.1   Ensembl cytogenetic band:  7p15.1   HGNC cytogenetic band: 7p15.2-p15.1

JAZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAZF1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027837:  view genomic region     (about GC identifiers)

Start:
27,870,192 bp from pter      End:
28,220,437 bp from pter
Size:
350,246 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,920,952-28,270,627     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6 (See protein sequence)
Recommended Name: Juxtaposed with another zinc finger protein 1  
Size: 243 amino acids; 27079 Da
Subunit: Interacts with TAK1
Miscellaneous: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1
RNA, resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is
characterized by JAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the
endometrium from late secretory and early proliferative phases of the menstrual cycle, but not in normal
myometrium at any phase of the cycle. Its expression is slightly induced by low levels of progesterone, but
suppressed by both estrogen and high levels of progesterone (PubMed:18772439)
Secondary accessions: A4D195 Q8N3L7
Alternative splicing: 2 isoforms:  Q86VZ6-1   Q86VZ6-2   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JAZF1: NX_Q86VZ6

Explore proteomics data for JAZF1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47
  • Modification sites at PhosphoSitePlus

  • See JAZF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_778231.2  
    ENSEMBL proteins: 
     ENSP00000388302   ENSP00000283928   ENSP00000387976   ENSP00000415096   ENSP00000415984  
     ENSP00000401829   ENSP00000399083  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q86VZ6

    ProtoNet protein and cluster: Q86VZ6

    UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
    Similarity: Contains 3 C2H2-type zinc fingers


    JAZF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAZF1_HUMAN, Q86VZ6
    Function: Potential transcription factor

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003714transcription corepressor activity IDA15302918
    GO:0046872metal ion binding IEA--
         
    JAZF1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for JAZF1:
     Increased circadian period len  Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAZF1
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    miRTarBase miRNAs that target JAZF1:
    hsa-mir-31-5p (MIRT004973), hsa-mir-96-5p (MIRT027883), hsa-let-7a-5p (MIRT052411), hsa-let-7e-5p (MIRT051478)

    Block miRNA regulation of human, mouse, rat JAZF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JAZF1 (see all 112):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-146a hsa-miR-106a hsa-miR-93 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidJAZF1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JAZF1_HUMAN, Q86VZ6: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017053transcriptional repressor complex IDA15302918

    JAZF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for JAZF1
    Interactions:

        Search GeneGlobe Interaction Network for JAZF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JAZF1 (Q86VZ63 ENSP000002839284) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NR2C2P491163, ENSP000003204474I2D: score=1 STRING: ENSP00000320447
    MAP3K7O433183I2D: score=1 
    MLST8ENSP000003718884STRING: ENSP00000371888
    CIAO1ENSP000004182874STRING: ENSP00000418287
    RPTORENSP000003072724STRING: ENSP00000307272
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA15302918
    GO:0006351transcription, DNA-templated IEA--

    JAZF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JAZF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for JAZF1 gene: 
    NM_175061.3  

    Unigene Cluster for JAZF1:

    JAZF zinc finger 1
    Hs.368944  [show with all ESTs]
    Unigene Representative Sequence: NM_175061
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000427814(uc003szm.3) ENST00000283928(uc003szn.3) ENST00000466516
    ENST00000430432 ENST00000447620 ENST00000452993 ENST00000420835 ENST00000454041

    miRNA
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    Block miRNA regulation of human, mouse, rat JAZF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JAZF1 (see all 112):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-520e hsa-miR-520f hsa-miR-146a hsa-miR-106a hsa-miR-93 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidJAZF1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat JAZF1

    Additional mRNA sequence: 

    AK000711.1 AK091311.1 AL832491.1 AY372319.1 BC042441.1 BC047229.1 

    7 DOTS entries:

    DT.100779449  DT.453881  DT.121046285  DT.121046177  DT.121046277  DT.75161380  DT.95183495 

    Selected AceView cDNA sequences (see all 26):

    AA351109 AY372319 AL834234 AK091311 BC047229 BX279610 AI198420 AX746909 
    BC042441 BU659479 AL832491 AA758058 AA431106 AA861804 AW296896 AA922111 
    AK000711 BU626449 AW084514 NM_175061 BG104990 AI990891 AA436677 BX427161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JAZF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAATTTCT
    JAZF1 Expression
    About this image


    JAZF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Adrenal Gland (Endocrine System)
    JAZF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JAZF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368944
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for JAZF1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jazf11 , 5 JAZF zinc finger 11, 5 92.32(n)1
    99.59(a)1
      6 (25.74 cM)5
    2319861  NM_173406.31  NP_775582.21 
     527687975 
    chicken
    (Gallus gallus)
    Aves JAZF11 JAZF zinc finger 1 87.38(n)
    98.35(a)
      420633  NM_001199618.1  NP_001186547.1 
    lizard
    (Anolis carolinensis)
    Reptilia JAZF16
    JAZF zinc finger 1
    98(a)
    1 ↔ 1
    GL343275.1(827265-944083)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.131772 Transcribed sequence 84.78(n)    BX726963.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jazf1a1 JAZF zinc finger 1a 76.19(n)
    86.15(a)
      561144  NM_001044955.1  NP_001038420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120541 CG12054 59.9(n)
    57.97(a)
      43694  NM_001260456.2  NP_001247385.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SFP16
    Transcription factor that controls expression of r...
    9(a)
    1 ↔ 1
    XII(925568-927619) YLR403W


    ENSEMBL Gene Tree for JAZF1 (if available)
    TreeFam Gene Tree for JAZF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JAZF1 gene
    2 SIMAP similar genes for JAZF1 using alignment to 7 protein entries:     JAZF1_HUMAN (see all proteins):
    DKFZp686M1922    A-328A3.4

    JAZF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JAZF1 (see all 7335)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs593421731,2
    C--27790980(+) CGCAC-/CCTGCTG 1 -- int11Minor allele frequency- CC:0.00NA 2
    rs105827991,2
    C--27831116(+) AAAAA-/A/AAA 
            
    CCCAC
    1 -- int11NA 2
    rs752551921,2
    F--27837100(+) TGTTAG/AAATCC 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs69484671,2
    C,F,A,H--27837166(+) TGTTAG/AGACAC 1 -- ds500116Minor allele frequency- A:0.31NS EA NA WA 1690
    rs730753541,2
    C,F--27837178(+) GCAGTC/GCTAGG 1 -- ds50011Minor allele frequency- G:0.12NA 120
    rs1481643201,2
    --27837214(+) CTTCCA/GGATAG 1 -- ds50010--------
    rs1829344891,2
    --27837215(+) TTCCAC/GATAGG 1 -- ds50010--------
    rs354105921,2
    C,F--27837305(+) AGTATC/ACTTGG 1 -- ds50013Minor allele frequency- A:0.33NA 6
    rs1872831121,2
    C--27837333(+) TAGACA/CCTGTT 1 -- ds50010--------
    rs1913211901,2
    --27837336(+) ACACTA/GTTCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for JAZF1 (27870192 - 28120192 bp, first 250kb of JAZF1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for JAZF1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1128518CNV Deletion17803354
    esv2658930CNV Deletion23128226
    esv1002613CNV Deletion20482838
    esv1940109CNV Deletion18987734
    esv2665878CNV Deletion23128226
    esv2461042CNV Deletion19546169
    esv2734174CNV Deletion23290073
    esv269333CNV Insertion20981092
    esv24518CNV Loss19812545
    nsv520555CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606246    OMIM disorders: --

    UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
  • Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation
    t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus
    part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal
    tumors, except in endometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1

  • Selected diseases for JAZF1 (see all 21):    
    About MalaCards
    endometrial stromal tumor    endometrial stromal sarcoma    insulin resistance    sarcoma
    diabetes mellitus    systemic lupus erythematosus    type 1 diabetes    lupus erythematosus
    inflammatory bowel disease    obesity    prostate cancer    rheumatoid arthritis
    arthritis    prostatitis    tonsillitis    pancreatitis
    thyroiditis    multiple myeloma    myeloma    cerebritis

    1 disease from the University of Copenhagen DISEASES database for JAZF1:
    Endometrial stromal sarcoma

    JAZF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): JAZF1
    Human Genome Epidemiology (HuGE) Navigator: JAZF1 (68 documents)

    Export disorders for JAZF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JAZF1 gene, integrated from 10 sources (see all 89):
    (articles sorted by number of sources associating them with JAZF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PubMed id 11371647)1, 2, 9 Koontz J.I.... Sklar J. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    2. A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. (PubMed id 18772439)1, 2, 9 Li H.... Sklar J. (Science 2008)
    3. Evidence for an association between prostate cancer and chromosome 8q24 and 10q11 genetic variants in African American men: the Flint Men's Health Study. (PubMed id 20717903)1, 4 Wang Y....Lange E.M. (Prostate 2011)
    4. Meta-analysis of genome-wide and replication association studies on prostate cancer. (PubMed id 20690139)1, 4 Liu H....Han C. (Prostate 2011)
    5. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PubMed id 20878950)1, 4 Sun J....Xu J. (Prostate 2011)
    6. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. (PubMed id 19833888)1, 4 Simonis-Bik A.M....'t Hart L.M. (Diabetes 2010)
    7. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (Diabetologia 2010)
    8. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PubMed id 20203524)1, 4 Pierce B.L. and Ahsan H. (Hum. Hered. 2010)
    9. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. (PubMed id 20161779)1, 4 Wen J....Hu R. (PLoS ONE 2010)
    10. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 221895 HGNC: 28917 AceView: JAZF1 Ensembl:ENSG00000153814 euGenes: HUgn221895
    ECgene: JAZF1 H-InvDB: JAZF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for JAZF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JAZF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for JAZF1 gene:
    Search GeneIP for patents involving JAZF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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