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JAZF1 Gene

protein-coding   GIFtS: 51

GC07M027837
JAZF zinc finger 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp761K2222 1, 2
TIP27 1, 2, 3, 5
ZNF802 1, 2, 3
Descriptions
JAZF zinc finger 1 2
TAK1-interacting protein 27 2, 3
Zinc finger protein 802 3
juxtaposed with another zinc finger gene 1 2
External Ids
HGNC: 289171
Entrez Gene: 2218952
UniProtKB: Q86VZ63
Ensembl: ENSG000001538147
Search outside databases for aliases for JAZF1 gene

Previous GC identifers: GC07U990333 GC07M027578 GC07M027612 GC07M027595 GC07M027643

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for JAZF1:
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a
transcriptional repressor. Chromosomal aberrations involving this gene are associated with
endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms
have been described; however, not all variants have been fully characterized [provided by RefSeq]

UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
Function: Potential transcription factor

Gene Wiki entry for JAZF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the JAZF1 gene  

Entrez Gene cytogenetic band: 7p15.2-p15.1   Ensembl cytogenetic band:  7p15.1   HGNC cytogenetic band: 7p15.2-p15.1

JAZF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027837:     (about GC identifiers)

Start:
27,836,717 bp from pter
End:
28,186,962 bp from pter
Size:
350,246 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,920,952-28,270,627     
RefSeq DNA sequence:
NC_000007.12  NT_007819.16  NT_079592.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6 (See protein sequence)
Recommended Name: Juxtaposed with another zinc finger protein 1  
Size: 243 amino acids; 27079 Da
Subunit: Interacts with TAK1
Subcellular location: Nucleus (Potential)
Secondary accessions: Q8N3L7
Alternative splicing: 2 isoforms:  Q86VZ6-1   Q86VZ6-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_778231.2  

    ENSEMBL proteins: 
    ENSP00000283928 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (JAZF1)
    Human Recombinant Proteins from Abnova (JAZF1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus IEA--
    GO:0017053 transcriptional repressor complex IDA15302918
    About this table

    Antibodies for JAZF1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for JAZF1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (JAZF1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (JAZF1)
    Novus Biologicals Antibodies for JAZF1

    Assays for JAZF1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2


       GeneDecks  JAZF1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q86VZ6

    ProtoNet protein and cluster: Q86VZ6

    UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
    Similarity: Contains 3 C2H2-type zinc fingers

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JAZF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (JAZF1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175061

                  Applied Biosystems Silencer® siRNAs for JAZF1

                  Sigma-Aldrich siRNA for JAZF1  
                         Sigma-Aldrich shRNA for JAZF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for JAZF1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_175061
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_175061
                                     untagged cDNA clone in CMV expression vector: NM_175061 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_175061

    UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
    Function: Potential transcription factor

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676 nucleic acid binding IEA--
    GO:0003714 transcription corepressor activity IDA15302918
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA15302918
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for JAZF1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JAZF1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (JAZF1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_175061

                  Sigma-Aldrich siRNA for JAZF1  
                         Sigma-Aldrich shRNA for JAZF1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_175061  

    REFSEQ mRNAs for JAZF1 gene: 

    NM_175061.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_175061  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_175061
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_175061
                                     untagged cDNA clone in CMV expression vector: NM_175061 

    Additional cDNA sequence: 

    AK000711.1 AK091311.1 AL832491.1 AY372319.1 BC042441.1 BC047229.1 CR619985.1 

    7 DOTS entries:

    DT.100779449  DT.453881  DT.121046285  DT.75161380  DT.121046177  DT.121046277  DT.95183495 

    24/26 AceView cDNA sequences (see all 26 ):

    AI198420 AA351109 AY372319 AL834234 BX279610 AK091311 AX746909 BC047229 
    AK000711 NM_175061 AA922111 AL832491 AA758058 BU659479 BC042441 AA861804 
    AW296896 BU626449 AA431106 AW084514 BG104990 AI990891 AA436677 BX427161 

    highest scoring ESTs for JAZF1:

    AI972531 AI990891 AK091311 AY372319 BC042441 BC047229 BU659479 AA012995 AA012996 AA034292 

    Unigene Cluster for JAZF1:

    JAZF zinc finger 1
    Hs.368944  [show with all ESTs]
    Unigene Representative Sequence: NM_175061


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000283928  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    JAZF1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for JAZF1

    1 / 2 / 3

    6 probe-sets matching JAZF1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51726_at2, 3 U95-B 1 1.00 1.00 0.92 0.99 AI990891 0.80 1.00 0.91 1
    57216_at2, 3 U95-C 1 1.00 1.00 0.97 1.02 AI972531 0.80 1.00 0.91 1

    225798_at2, 3 U133-B 1 1.00 1.00 -- -- AL047908 0.40 0.67 0.55 1

    225800_at2, 3 U133-B 1 1.00 1.00 -- -- AI990891 0.80 1.00 0.91 1

    225798_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    225800_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  JAZF1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTAAATTTCT

    SOURCE GeneReport for Unigene cluster: Hs.368944
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for JAZF1 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    JAZF11   -- JAZF zinc finger 1 95.12(n)
    100(a)
    475265  XM_532499.2  XP_532499.2 
    chimpanzee
    (Pan troglodytes)
    JAZF11   -- JAZF zinc finger 1 99.73(n)
    100(a)
    472646  XM_001163921.1  XP_001163921.1 
    cow
    (Bos taurus)
    JAZF11   -- JAZF zinc finger 1 94.92(n)
    100(a)
    616701  XM_868795.2  XP_873888.2 
    rat
    (Rattus norvegicus)
    Jazf11   -- JAZF zinc finger 1 93.42(n)
    99.59(a)
    685879  XM_001065610.1  XP_001065610.1 
    mouse
    (Mus musculus)
    Jazf11, 5 6 (25.90 cM)5
    JAZF zinc finger 11, 5 92.18(n)1
    99.18(a)1
    2319861  NM_173406.21  NP_775582.11 
     AI4281355  AI5914765  (see all 9)
    About this table        Species with no ortholog for JAZF1

    ENSEMBL Gene Tree for JAZF1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1891 NCBI SNPs in JAZF1 are shown (see all 1891 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 622)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 7 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs78095261,2
    A,C,H28188132(+) TGCTTA/TGAGTA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 390
    rs7402571,2
    F,H28187356(+) AAAAAG/ATACAC 1 -- ng318Minor allele frequency- A:0.01NA EA MN EU WA 836
    rs10433641,2
    F27836720(+) TATTTA/TTTTTT 1 -- ut311Minor allele frequency- T:0.01MN 184
    rs7402561,2
    F28187061(+) CGCGGA/GCCCAG 1 -- ng311Minor allele frequency- G:0.02MN 184
    rs8491351,2
    A,C,F,H,O28162938(+) AGTACG/ATCACC 1 -- int17Minor allele frequency- A:0.22EU EA WA NA 538
    rs21899661,2
    A,C,F,H,O28138591(+) CTGCCC/TGCAAA 1 -- int17Minor allele frequency- T:0.31EU EA WA NA 534
    rs8491421,2
    A,C,F,H,O28152416(-) GTTCTA/GATCTT 1 -- int17Minor allele frequency- G:0.20EU EA WA NA 558
    rs19899091,2
    A,C,F,H,O27924382(+) TACTGC/AACTTT 1 -- int15Minor allele frequency- A:0.26EU WA NA 374
    rs9577641,2
    A,C,F,H,O27967851(-) GTCCAA/GCTAGC 1 -- int17Minor allele frequency- G:0.03NA EA EU WA 670
    rs5061541,2
    A,C,F,H,O28168604(+) GTTCAC/TGTAAG 1 -- int111Minor allele frequency- T:0.13EU EA WA NA 958
    About this table

    HapMap Linkage Disequilibrium images for JAZF1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 606246

    UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6

  • A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors.
    Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene
    consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently
    found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it
    is rarer
  • Human Genome Epidemiology Navigator: JAZF1 (16 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/35 PubMed articles for JAZF1 gene (see all 35 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 221895 HGNC: 28917 AceView: JAZF1 Ensembl:ENSG00000153814 euGenes: HUgn221895
    ECgene: JAZF1 H-InvDB: JAZF1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for JAZF1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for JAZF1-related products

     Millipore Custom Antibody & Bulk Services
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     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for JAZF1 Antibodies for JAZF1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for JAZF1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for JAZF1

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