JAZF1 Gene
protein-coding GIFtS: 50
GCID: GC07M027837
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JAZF zinc finger 1
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Aliases for JAZF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| JAZF Zinc Finger 11 2 | | TAK1-Interacting Protein 272 3 | | TIP271 2 3 5 | | DKFZp761K22221 | | ZNF8021 2 3 | | Juxtaposed With Another Zinc Finger Gene 12 | | Zinc Finger Protein 8022 3 | | Juxtaposed With Another Zinc Finger Protein 12 |
Export aliases for JAZF1 gene to outside databasesPrevious GC identifers: GC07U990333 GC07M027578 GC07M027612 GC07M027595 GC07M027643 GC07M027752 |
Summaries for JAZF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for JAZF1: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor.Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively splicedvariants which encode different protein isoforms have been described; however, not all variants have been fullycharacterized (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6Function: Potential transcription factor Gene Wiki entry for JAZF1
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Genomic Views for JAZF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the JAZF1 gene promoter: AML1a Pbx1a HOXA3 MyoD Nkx2-5 Tal-1beta E47 E2F-1 E2F RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for JAZF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAZF1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p15.2-p15.1 Ensembl cytogenetic band: 7p15.1 HGNC cytogenetic band: 7p15.2-p15.1JAZF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M027837: view genomic region
(about GC identifiers)
Start:
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27,870,192 bp from pter |
End:
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28,220,437 bp from pter |
Size:
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350,246 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 27,920,952-28,270,627 |
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Proteins for JAZF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6 (See
protein sequence)Recommended Name: Juxtaposed with another zinc finger protein 1 Size: 243 amino acids; 27079 Da
Subunit: Interacts with TAK1
Subcellular location: Nucleus (Potential)
Miscellaneous: Under hypoxic conditions, the precursor SUZ12 RNA undergoes regulated trans-splicing with the JAZF1 RNA,resulting in a chimeric isoform which may be protective against apoptosis. The chimeric transcript is characterized byJAZF1 exons 1-3 joined to SUZ12 exon 2-16. The chimeric transcript is expressed primarily in the endometrium from latesecretory and early proliferative phases of the menstrual cycle, but not in normal myometrium at any phase of thecycle. Its expression is slightly induced by low levels of progesterone, but suppressed by both estrogen and highlevels of progesterone (PubMed:18772439)
Secondary accessions: A4D195 Q8N3L7Alternative splicing: 2 isoforms: Q86VZ6-1 Q86VZ6-2 (Incomplete sequence. No experimental confirmation available)Explore the universe of human proteins at neXtProt for JAZF1: NX_Q86VZ6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VZ6 JAZF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_778231.2 ENSEMBL proteins: ENSP00000388302 ENSP00000283928 ENSP00000387976 ENSP00000415096 ENSP00000415984 ENSP00000401829 ENSP00000399083 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
JAZF1 for ontologies About GeneDecksing
JAZF1 Antibody Products: Assay Products for JAZF1: |
Protein
Domains / Families for JAZF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JAZF1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86VZ6ProtoNet protein and cluster: Q86VZ6 UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6Similarity: Contains 3 C2H2-type zinc fingers |
Function for JAZF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6Function: Potential transcription factor
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAZF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAZF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for JAZF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAZF1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAZF1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
JAZF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for JAZF1:
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Pathways & Interactions for JAZF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JAZF1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for JAZF1 (Q86VZ63 ENSP000002839284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | 15302918 | | GO:0006351 | transcription, DNA-dependent |
IEA | -- |
JAZF1 for ontologies About GeneDecksing
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Drugs & Compounds for JAZF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for JAZF1 Search CenterWatch for drugs/clinical trials and news about JAZF1 
|
Transcripts for JAZF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for JAZF1 gene: NM_175061.3 Unigene Cluster for JAZF1: JAZF zinc finger 1 Hs.368944 [show with all ESTs]Unigene Representative Sequence: NM_1750618 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000427814(uc003szm.3) ENST00000283928(uc003szn.3) ENST00000466516 ENST00000430432 ENST00000447620 ENST00000452993 ENST00000420835 ENST00000454041
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAZF1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAZF1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: JAZF1 (NM_175061) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JAZF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAZF1  |
Additional cDNA sequence: AK000711.1 AK091311.1 AL832491.1 AY372319.1 BC042441.1 BC047229.1 7 DOTS entries: DT.100779449 DT.453881 DT.121046285 DT.121046177 DT.121046277 DT.75161380 DT.95183495 24/26 AceView cDNA sequences (see all 26): AK091311 AA351109 AL834234 AX746909 AI198420 AY372319 BX279610 BC047229 AW296896 AK000711 AA758058 AA922111 BC042441 NM_175061 AA431106 BU659479 AL832491 AA861804 BU626449 AW084514 BG104990 AI990891 AA436677 BX427161 GeneLoc Exon Structure
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Expression for JAZF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JAZF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTAAATTTCT
About this image See JAZF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for JAZF1
SOURCE GeneReport for Unigene cluster: Hs.368944 SABiosciences Custom PCR Arrays for JAZF1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JAZF1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JAZF1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAZF1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAZF1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAZF1 |
Orthologs for JAZF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for JAZF1 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for JAZF1 (if available) TreeFam Gene Tree for JAZF1 (if available)  |
Paralogs for JAZF1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for JAZF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for JAZF1 (27870192 - 28120192 bp, first 250kb of JAZF1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 6 variations for JAZF1 2 CNVs: 99903 3672 4 Indels: 69838 47331 40964 28618  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JAZF1 |
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Disorders
/ Diseases for JAZF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JAZF1 for disorders About GeneDecksing
OMIM gene information: 606246
OMIM disorders: --
UniProtKB/Swiss-Prot: JAZF1_HUMAN, Q86VZ6
Note=A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocationt(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part ofJAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except inendometrial stromal sarcomas, where it is rarer. Translocation t(6;7)(p21;p22) with PHF1 12 diseases for JAZF1: About MalaCardsendometrial stromal tumor ovarian sex cord tumors endometrial stromal sarcoma systemic lupus erythematosus lupus erythematosus diabetes mellitus rheumatoid arthritis sarcoma prostate cancer arthritis prostatitis obesity 1 disease from the University of Copenhagen DISEASES database for JAZF1:Endometrial stromal sarcoma Human Genome Epidemiology (HuGE) Navigator: JAZF1 (68 documents) Export disorders for JAZF1 gene to outside databases
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Publications for JAZF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JAZF1 gene, integrated from 9 sources (see all 76): (articles sorted by number of sources associating them with JAZF1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. (PubMed id 11371647)1, 2, 9 Koontz J.I.... Sklar J. (2001)
- A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. (PubMed id 18772439)1, 2, 9 Li H....Sklar J. (2008)
- Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. (PubMed id 16397222)1, 2 Micci F....Heim S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. (PubMed id 8401585)1, 3 Adams M.D....Venter J.C. (1993)
- Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. (PubMed id 18077430)1, 9 Li H....Sklar J. (2007)
- Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. (PubMed id 17197920)1, 9 Nucci M.R....Sklar J. (2007)
- High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. (PubMed id 17667554)1, 9 Oliva E....Herens C. (2007)
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External Searches for JAZF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing JAZF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JAZF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JAZF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for JAZF1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for JAZF1 gene: Search GeneIP for patents involving JAZF1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for JAZF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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 | | JAZF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAZF1 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAZF1 |
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