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Aliases & Descriptions for JARID2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| JMJ 2, 3 | | OTTHUMP00000016058 2 |
| | | Descriptions |
|---|
| Jumonji/ARID domain-containing protein 2 3 | | jumonji (mouse) homolog 1 | | jumonji homolog 2 | | jumonji, AT rich interactive domain 2 1, 2 | | jumonji, AT rich interactive domain 2 protein 2 | | jumonji-like protein 2 |
|
| | Search outside databases for aliases for JARID2 gene |
Summaries for JARID2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for JARID2: This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein. [provided by RefSeq] UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833Function: Required for neural tube formation. Essential for normal heart development and function. Acts as a transcriptional repressor of ANF by binding to both GATA4 and NKX2-5 and repressing their transcriptional activator activities. Participates in the negative regulation of cell proliferation signaling (By similarity)Gene Wiki entry for JARID2 |
Genomic Location for JARID2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the JARID2 gene 
Entrez Gene cytogenetic band: 6p24-p23 Ensembl cytogenetic band: 6p23 HGNC cytogenetic band: 6p24-p23JARID2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P015354:
(about GC identifiers)
Start:
|
15,354,506 bp from pter |
End:
|
15,630,232 bp from pter |
Size:
|
275,727 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for JARID2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833 (See
protein sequence)Recommended Name: Protein Jumonji Size: 1246 amino acids; 138734 Da
Subunit: Interacts with the N-terminal region of GATA4 and the C-terminal region of the NKX2-5 homeobox and represses their ability to activate transcription of ANF (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAC50822.1; Type=Frameshift; Positions=1233;
Secondary accessions: Q5U5L5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004964.2
ENSEMBL proteins: ENSP00000380478 ENSP00000341280
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for JARID2: Assays for JARID2: | Protein
Domains/ Families for JARID2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q92833
ProtoNet protein and cluster: Q92833 4 Blocks protein families: IPB001606 ARID (AT-rich interaction domain) protein IPB003347 Transcription factor jumonji IPB003349 Transcription factor jumonji IPB004198 Zn-finger
UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833Similarity: Contains 1 ARID domainSimilarity: Contains 1 JmjC domainSimilarity: Contains 1 JmjN domain | Gene Function for JARID2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004973
Applied Biosystems Silencer® siRNAs for JARID2
Sigma-Aldrich siRNA and siRNA Panels for JARID2  Sigma-Aldrich shRNA for JARID2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004973                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004973                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004973 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004973
UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833Function: Required for neural tube formation. Essential for normal heart development and function. Acts as a transcriptional repressor of ANF by binding to both GATA4 and NKX2-5 and repressing their transcriptional activator activities. Participates in the negative regulation of cell proliferation signaling (By similarity)13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Jarid2):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for JARID2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for JARID2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for JARID2 
5/6 Interacting proteins for JARID2 (ENSP000003412803) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0001889 | liver development |
IEA | -- | | GO:0006350 | transcription |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007417 | central nervous system development |
TAS | 8894700 | About this table
|
Drugs & Compounds for JARID2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for JARID2
|
Transcripts for JARID2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004973
Sigma-Aldrich siRNA and siRNA Panels for JARID2  Sigma-Aldrich shRNA for JARID2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004973 REFSEQ mRNAs for JARID2 gene: NM_004973.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004973               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004973                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004973                                  untagged cDNA clones in CMV expression vector (see all 2): NM_004973  Additional cDNA sequence: AF401209.1 AK126552.1 AK292861.1 AK299349.1 AK302624.1 AK303610.1 BC046184.1 BC046246.1 CR590032.1 U57592.1 10 DOTS entries: DT.444424 DT.40207464 DT.102829683 DT.75188233 DT.95276726 DT.75107260 DT.95258682 DT.121313238 DT.40131726 DT.97785783 24/215 AceView cDNA sequences (see all 215
):BE218837 AI752994 BU187019 BX279637 BF222387 AI653290 AI911157 BM542826 BG981124 AW513927 AW016429 AF401209 CD676149 AA987384 CD652986 AI365114 AL041595 AI680664 CA435807 BM968533 BM798129 BM272468 BF431048 NM_004973
highest scoring ESTs for JARID2:AA142951 AA150661 AA194045 AA354817 AA479986 AA564451 AA653601 AA810151 AA910566 AA931169 Unigene Cluster for JARID2: Jumonji, AT rich interactive domain 2 Hs.630189 [show with all ESTs]Unigene Representative Sequence: NM_004973
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for JARID2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for JARID2
2 Ensembl transcripts including schematic representations: ENST00000397311
ENST00000341776
|
Expression for JARID2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| JARID2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for JARID2
1 / 2 / 3 7 probe-sets matching JARID2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGTTTATTG
SOURCE GeneReport for Unigene cluster: Hs.630189
Expression variation in blood from EXPOLDB for JARID2 UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833Tissue specificity: During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells |
Orthologs for JARID2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for JARID2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for JARID2
ENSEMBL Gene Tree for JARID2 | Paralogs for JARID2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for JARID2 gene
- KDM4D2 KDM4A2 KDM4C2 KDM4B2
|
SNPs/Variants for JARID2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for JARID2 (up to first 250kb)
|
Disorders & Mutations for JARID2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601594
Human Genome Epidemiology Navigator: JARID2 (1 document)
|
Medical News for JARID2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for JARID2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for JARID2 gene (see all 15
):- Characterization of the human jumonji gene. (PubMed id 8894700)2, 3, 4 Berge-Lefranc J.-L.... Fontes M. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. (PubMed id 18805276)1, 3 Bovill E....Shaw T. (2008)
- Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PubMed id 19010793)3 Baranzini S.E....Oksenberg J.R. (2008)
- Positive association of schizophrenia to JARID2 gene. (PubMed id 16967465)3 Pedrosa E....Lachman H.M. (2007)
- Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. (PubMed id 15542826)3 Kim T.G....Lee Y. (2004)
- Evaluation of the jumonji gene and risk for spina bifida and congenital heart defects. (PubMed id 15057990)3 Volcik K.A....Lammer E.J. (2004)
- JUMONJI, a critical factor for cardiac development, functions as a transcriptional repressor. (PubMed id 12890668)3 Kim T.G....Lee Y. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for JARID2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing JARID2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing JARID2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JARID2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for JARID2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for JARID2:

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Incremental update: 13 Oct 2009
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