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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JARID2 Gene

protein-coding   GIFtS: 57
GCID: GC06P015246

jumonji, AT rich interactive domain 2

(Previous names: jumonji (mouse) homolog, Jumonji, AT rich interactive domain...)
(Previous symbol: JMJ)
 Explore 9 diseases affiliated with
JARID2 via
MalaCards
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 Human Malady Compendium 
Biological research products
for JARID2    

Aliases
for JARID2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Jumonji, AT Rich Interactive Domain 21 2     Jumonji Homolog2
JMJ1 2 3 5     Jumonji-Like Protein2
Jumonji/ARID Domain-Containing Protein 22 3     Protein Jumonji2
Jumonji (Mouse) Homolog1     

External Ids:    HGNC: 61961   Entrez Gene: 37202   Ensembl: ENSG000000080837   OMIM: 6015945   UniProtKB: Q928333   

Export aliases for JARID2 gene to outside databases

Previous GC identifer: GC06P015354


Summaries
for JARID2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for JARID2:
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a
DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive
complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This
protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple
transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. (provided by RefSeq, May
2012)

UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833
Function: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development,
including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone
methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.
Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have
histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem
cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the
PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac
cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3
(H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF
via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling

Gene Wiki entry for JARID2


Genomic Views
for JARID2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JARID2 gene promoter:
         MEF-2A   aMEF-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JARID2 promoter sequence
   Search SABiosciences Chromatin IP Primers for JARID2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JARID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24-p23   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p24-p23

JARID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JARID2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P015246:  view genomic region     (about GC identifiers)

Start:
 15,246,527 bp from pter      End:
 15,522,253 bp from pter
Size:
 275,727 bases      Orientation:
 plus strand

Proteins
for JARID2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833 (See protein sequence)
Recommended Name: Protein Jumonji  
Size: 1246 amino acids; 138734 Da
Subunit: Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12;
the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal
region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes
EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to
PRC2 via its interaction with SUZ12
Subcellular location: Nucleus. Note=Colocalizes with the PRC2 complex on chromatin
Sequence caution: Sequence=AAC50822.1; Type=Frameshift; Positions=1233;
Secondary accessions: A8K9Z6 B7Z5S5 B7Z8L0 Q5U5L5 Q86X63
Alternative splicing: 3 isoforms:  Q92833-1   Q92833-2   Q92833-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JARID2: NX_Q92833

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92833

    • JARID2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001253969.1  NP_004964.2  

    ENSEMBL proteins: 
     ENSP00000341280   ENSP00000444623   ENSP00000380478  

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    Uscn Proteins for JARID2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0035097histone methyltransferase complex ISS--
    GO:0035098colocalizes with ESC/E(Z) complex IDA--


    JARID2 for ontologies           About GeneDecksing



    JARID2 Antibody Products: 
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    Uscn ELISAs and CLIAs for JARID2

    Protein Domains /
    Families
    for JARID2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    JARID2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003347 JmjC_dom
     IPR003349 TF_JmjN
     IPR004198 Znf_C5HC2
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q92833

    ProtoNet protein and cluster: Q92833

    4 Blocks protein families:
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB003347 Transcription factor jumonji
    IPB003349 Transcription factor jumonji
    IPB004198 Zn-finger


    UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833
    Domain: The ARID domain is required to target the PRC2 complex to its target genes (By similarity)
    Domain: The GSGFP motif is required for the interaction with SUZ12 (By similarity)
    Similarity: Contains 1 ARID domain
    Similarity: Contains 1 JmjC domain
    Similarity: Contains 1 JmjN domain


    Function
    for JARID2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833
    Function: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development,
    including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone
    methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.
    Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have
    histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem
    cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the
    PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac
    cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3
    (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF
    via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling

    miRNA
    Products:            		miRTarBase miRNAs that target JARID2:
    hsa-mir-204 (MIRT005834), hsa-mir-155 (MIRT001075)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JARID2
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate JARID2 (see all 113):
    hsa-miR-548j hsa-miR-188-5p hsa-miR-15a hsa-miR-30d hsa-miR-3161 hsa-miR-30a hsa-miR-3613-3p hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: JARID2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JARID2 (see all 4)
    OriGene shRNA RFP: JARID2
    OriGene siRNA: JARID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JARID2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: JARID2 (NM_004973)
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    Search LifeMap BioReagents cell lines for JARID2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JARID2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding ISS--
    GO:0005515protein binding ----
    GO:0032452NOT histone demethylase activity ISS--


    JARID2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for JARID2:
     Increased G1 DNA content 

    Animal Models:
         14 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Jarid2):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system  normal  respiratory system  skeleton 

    JARID2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for JARID2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for JARID2
        Transcriptional Regulatory Network in Embryonic Stem Cell


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JARID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for JARID2 (Q928333 ENSP000003412804) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EZH2Q159103, ENSP000003201474I2D: score=3 STRING: ENSP00000320147
    BCLAF1Q9NYF83, ENSP000000311354I2D: score=2 STRING: ENSP00000031135
    EEDO755303, ENSP000002633604I2D: score=2 STRING: ENSP00000263360
    RBBP4Q090283, ENSP000003625924I2D: score=2 STRING: ENSP00000362592
    EHMT1Q9H9B13, ENSP000004179804I2D: score=1 STRING: ENSP00000417980
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001889liver development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007417central nervous system development TAS8894700
    GO:0008285negative regulation of cell proliferation IEA--


    JARID2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for JARID2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JARID2
    Search CenterWatch for drugs/clinical trials and news about JARID2 / JARD2 

    Transcripts
    for JARID2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for JARID2 gene (2 alternative transcripts): 
    NM_001267040.1  NM_004973.3  

    Unigene Cluster for JARID2:

    Jumonji, AT rich interactive domain 2
    Hs.269059  [show with all ESTs]
    Unigene Representative Sequence: NM_004973
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341776(uc003nbj.3 uc011div.2) ENST00000474854 ENST00000541660(uc011diw.1)
    ENST00000397311(uc011diu.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: JARID2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JARID2
    8/113 QIAGEN miScript miRNA Assays for microRNAs that regulate JARID2 (see all 113):
    hsa-miR-548j hsa-miR-188-5p hsa-miR-15a hsa-miR-30d hsa-miR-3161 hsa-miR-30a hsa-miR-3613-3p hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmid: JARID2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JARID2 (see all 4)
    OriGene shRNA RFP: JARID2
    OriGene siRNA: JARID2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JARID2
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: JARID2 (NM_004973)
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    Primer
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    Additional cDNA sequence: 

    AF401209.1 AK126552.1 AK292861.1 AK299349.1 AK302624.1 AK303610.1 BC046184.1 BC046246.1 
    U57592.1 

    10 DOTS entries:

    DT.444424  DT.40207464  DT.102829683  DT.75188233  DT.95276726  DT.75107260  DT.95258682  DT.121313238 
    DT.40131726  DT.97785783 

    24/215 AceView cDNA sequences (see all 215):

    BM829064 BM968533 AA135538 AL041595 AA872169 BG236420 BM798129 BM542826 
    AW136064 AI337033 AI188206 AI911157 BU187019 BF222326 CA435807 AI365114 
    AI637645 AI752994 CD676149 BE046005 BM272468 AA679065 BI857543 BE218837 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for JARID2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19
    SP1:                                                  -           -                       -           -                       -               
    SP2:                                                                                                                                          
    SP3:                                                                                      -                                                   
    SP4:                                                                                                                                          


    ECgene alternative splicing isoforms for JARID2

    Expression
    for JARID2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JARID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTTTATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    JARID2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudHepatoblastsLiver
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Induced pluripotent stem cell line hIPS1 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Induced pluripotent stem cell line hIPS2 (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast

    See JARID2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JARID2

    SOURCE GeneReport for Unigene cluster: Hs.269059

    UniProtKB/Swiss-Prot: JARD2_HUMAN, Q92833
    Tissue specificity: During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion
    cells

        SABiosciences Expression via Pathway-Focused PCR Array including JARID2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JARID2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JARID2

    Orthologs
    for JARID2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for JARID2 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves JARID21 jumonji, AT rich interactive domain 2 83.06(n)
    87.48(a)    		   420839  NM_001012862.1  NP_001012880.1 
    lizard
    (Anolis carolinensis)    		 Reptilia JARID26
    		 --
    		 80(a)
    		 1 ↔ 1
    		 4(58052812-58161348)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.79232 Xenopus laevis transcribed sequence with strong similarity more 88.15(n)    CF548744.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii jarid2b1 jumonji, AT rich interactive domain 2b 67(n)
    64.87(a)    		   558456  NM_001202459.1  NP_001189388.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Jarid21 Jumonji, AT rich interactive domain 2 45.9(n)
    33.65(a)    		   39103  NM_140067.1  NP_648324.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons REF66
    ELF66
    (see all 3)    		 jumonji/Zn finger-class transcription factor ELF6
    (see all 3)    		 7(a)
    7(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 3(17935609-17940746)
    5(1169544-1174878)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 ZOS12-04 - C2H2 zinc finger protein, expressed
    (see all 5)    		 8(a)
    7(a)
    (see all 5)    		 1 ↔ many
    1 ↔ many
    (see all 5)    		 2(28636904-28639754)
    12(10465595-10475811)


    ENSEMBL Gene Tree for JARID2 (if available)
    TreeFam Gene Tree for JARID2 (if available) 

    Paralogs
    for JARID2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JARID2 gene
    KDM5C2  KDM5B2  KDM5A2  KDM5D2  
    3 SIMAP similar genes for JARID2 using alignment to 2 protein entries:     JARD2_HUMAN (see all proteins):
    KDM5C    PLU-1    KDM5A

    JARID2 for paralogs           About GeneDecksing



    Genomic Variants
    for JARID2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5079 NCBI SNPs in JARID2 are shown (see all 5079)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs753527701,2
    		F,--15244210(+) TGCCTA/GGTTTT 1 -- us2k13Minor allele frequency- G:0.07WA NA EA 358
    rs788551031,2
    		C,F,--15244249(+) ATCATC/TCCCAC 1 -- us2k13Minor allele frequency- T:0.13WA NA EA 358
    rs1456676561,2
    		--15244262(+) GTTTGA/GTCACC 1 -- us2k10--------
    rs1495606941,2
    		--15244398(+) AGGTTA/CTCTCT 1 -- us2k10--------
    rs1442596661,2
    		--15244490(+) ATATAC/TGGGTA 1 -- us2k10--------
    rs1926323321,2
    		--15244660(+) AAGCGA/CTATGC 1 -- us2k10--------
    rs1483718111,2
    		--15244935(+) CTCAGA/GAGGCA 1 -- us2k10--------
    rs1415930051,2
    		--15244964(+) CTGGGC/TCACCA 1 -- us2k10--------
    rs1123080031,2
    		C,--15245077(+) CGGCCG/ACCGCC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs761050141,2
    		C,F,--15245144(+) CTACCC/TTAGGC 1 -- us2k12Minor allele frequency- T:0.12NA EA 240

    HapMap Linkage Disequilibrium report for JARID2 (15246527 - 15496527 bp, first 250kb of JARID2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for JARID2
         1 Indel: 69337

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    Disorders / Diseases
    for JARID2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    JARID2 for disorders           About GeneDecksing

    OMIM gene information: 601594    OMIM disorders: --

    9 diseases for JARID2:    About MalaCards
    myeloid malignancy    spina bifida    congenital heart defect    multiple sclerosis
    hematopoiesis    retinoblastoma    schizophrenia    malaria
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: JARID2 (2 documents)

    Export disorders for JARID2 gene to outside databases

    Publications
    for JARID2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JARID2 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with JARID2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human jumonji gene. (PubMed id 8894700)1, 2, 3 Berge-Lefranc J.-L.... Fontes M. (1996)
    2. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. (PubMed id 20075857)1, 2 Pasini D.... Helin K. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. A jumonji (Jarid2) protein complex represses cyclin D1 expression by methylation of histone H3-K9. (PubMed id 19010785)1, 9 Shirato H....Takeuchi T. (2009)
    6. Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. (PubMed id 18805276)1, 9 Bovill E....Shaw T. (2008)
    7. Jarid2 (Jumonji, AT rich interactive domain 2) regulat es NOTCH1 expression via histone modification in the developing heart. (PubMed id 22110129)1 Mysliwiec M.R....Lee Y. (2012)
    8. PRC2 directly methylates GATA4 and represses its trans criptional activity. (PubMed id 22215809)1 He A....Pu W.T. (2012)
    9. Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women . (PubMed id 22116950)1 Schuh-Huerta S.M....Reijo Pera R.A. (2012)
    10. Frequent deletions of JARID2 in leukemic transformatio n of chronic myeloid malignancies. (PubMed id 22190018)1 Puda A....Kralovics R. (2012)

    External Searches for JARID2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing JARID2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3720 HGNC: 6196 AceView: JARID2 Ensembl:ENSG00000008083 euGenes: HUgn3720
    ECgene: JARID2 H-InvDB: JARID2

    Other Databases showing JARID2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing JARID2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JARID2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JARID2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for JARID2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for JARID2 gene:
    Search GeneIP for patents involving JARID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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