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KDM5C Gene

protein-coding GIFtS: 51

GC0XM053237

lysine (K)-specific demethylase 5C
(Previous names: Jumonji, AT rich interactive domain 1C (RBP2-like), Smcy homolog, X-linked (mouse), jumonji, AT rich interactive domain 1C )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: SMCX, JARID1C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DXS1272E ^¹, ², ³
EC 1.14.11.- ^³
JARID1C ^², ³
MRXJ ^²
MRXSJ ^²
OTTHUMP00000023342 ^²
SMCX ^², ³
XE169 ^¹, ², ³

Descriptions
Histone demethylase JARID1C ^³
JmjC domain-containing protein SMCX ^²
Jumonji, AT rich interactive domain 1C (RBP2-like) ^¹, ²
Jumonji/ARID domain-containing protein 1C ^², ³
Protein SmcX ^³
Protein Xe169 ^³
Smcx homolog, X chromosome ^²
Smcy homolog, X-linked ^²
Smcy homolog, X-linked (mouse) ^¹
jumonji, AT rich interactive domain 1C ^¹, ²
lysine (K)-specific demethylase 5C ^²
lysine-specific demethylase 5C ^¹
selected cDNA on X ^²

External Ids
HGNC: 11114¹
Entrez Gene: 8242²
UniProtKB: P41229³
Ensembl: ENSG00000126012⁷

Search outside databases for aliases for KDM5C gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KDM5C:

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one

JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this

protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this

gene have been associated with X-linked mental retardation. Alternative splicing results in

multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing

a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36',

H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3

'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone

deacetylases and REST at neuron-restrictive silencer elements

Gene Wiki entry for KDM5C (JARID1C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.22-p11.21 Ensembl cytogenetic band: Xp11.22 HGNC cytogenetic band: Xp11.22-p11.21

KDM5C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM053237: (about GC identifiers)

Start:	53,237,378 bp from pter
End:	53,271,329 bp from pter
Size:	33,952 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011630.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229 (See protein sequence)

Recommended Name: Lysine-specific demethylase 5C

Size: 1560 amino acids; 175720 Da

Cofactor: Alpha-ketoglutarate

Cofactor: Fe(2+)

Subunit: Part of two distinct complexes, one containing E2F6, and the other containing REST

Subcellular location: Nucleus

Miscellaneous: Escapes X-inactivation

PDB structures from and Proteopedia :

2JRZ (3D)

Secondary accessions: Q5JUX3 Q5JUX4 Q5JUX5 Q7Z5S5

Alternative splicing: 3 isoforms: P41229-1 P41229-2 P41229-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001140174.1 NP_004178.2

ENSEMBL proteins:

ENSP00000364532 ENSP00000364528 ENSP00000385394 ENSP00000344004 ENSP00000364550

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KDM5C / Jarid1C / SMCX)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--

About this table

Antibodies for KDM5C:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KDM5C / Jarid1C / SMCX), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for JARID1C

Assays for KDM5C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P41229

ProtoNet protein and cluster: P41229

5/6 Blocks protein families (see all 6 ):

IPB001606 ARID (AT-rich interaction domain) protein

IPB001965 Zn-finger-like

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

IPB004198 Zn-finger

UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229

Domain: The first PHD-type zinc finger domain recognizes and binds H3-K9Me3

Domain: Both the JmjC domain and the JmjN domain are required for enzymatic activity

Similarity: Belongs to the JARID1 histone demethylase family

Similarity: Contains 1 ARID domain

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 2 PHD-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM5C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMCX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004187

Applied Biosystems Silencer® siRNAs for KDM5C

Sigma-Aldrich siRNA and siRNA Panels for KDM5C

Sigma-Aldrich shRNA for KDM5C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004187
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004187
untagged cDNA clones in CMV expression vector (see all 2): NM_004187

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004187

UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing

a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36',

H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3

'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone

deacetylases and REST at neuron-restrictive silencer elements

Enzyme Number (IUBMB): EC 1.14.11.-

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	17320160
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/19 Interacting proteins for KDM5C (P41229¹ ENSP00000364550³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
- - (xeno)	P68432¹	EBI-1246541, EBI-79764
DLG3	ENSP00000194900³	STRING (score=.882)
IQSEC2	ENSP00000364517³	STRING (score=.872)
SMAD3	ENSP00000332973³	STRING (score=.864)
SMC1A	ENSP00000323421³	STRING (score=.84)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--
GO:0016568	chromatin modification	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KDM5C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM5C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SMCX)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004187

Sigma-Aldrich siRNA and siRNA Panels for KDM5C

Sigma-Aldrich shRNA for KDM5C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004187

REFSEQ mRNAs for KDM5C gene (2 alternative transcripts):

NM_001146702.1 NM_004187.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004187

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004187
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004187
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004187

Additional cDNA sequence:

AF069136.1 AK304732.1 AK308077.1 AY927525.1 AY927613.1 AY927614.1 BC054499.2 CR602759.1

EF613277.1 L25270.1 Z29650.1

15 DOTS entries:

DT.314594 DT.100817390 DT.92428580 DT.95195172 DT.86857392 DT.95249943 DT.100817379 DT.121298854

DT.100817387 DT.100817394 DT.100840162 DT.121298874 DT.87012280 DT.100817385 DT.100830833

24/327 AceView cDNA sequences (see all 327 ):

AL556381 BM783479 AA485054 BU633909 BM783422 CR605926 AA485380 BF095232

BU153721 BM987215 BQ218951 AI017396 AW576154 BM678964 BM977359 BM970490

T29064 AA807623 CB243084 AL698849 BM015635 BF058094 AA348318 BG684126

Unigene Cluster for KDM5C:

Lysine (K)-specific demethylase 5C

Hs.631768 [show with all ESTs]

Unigene Representative Sequence: NM_004187

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for KDM5C (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^
SP1:									-		-		-		-				-		-																		-
SP2:									-		-		-		-				-		-																		-
SP3:									-						-				-		-
SP4:																			-		-
SP5:

ExUns:	16a	·	16b	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	^	21	^	22a	·	22b	^	23a	·	23b	^	24	^	25a	·	25b	·	25c	^	26a	·	26b	^	27	^	28
SP1:									-								-
SP2:									-								-
SP3:
SP4:
SP5:																											-

About this scheme

ECgene alternative splicing isoforms for KDM5C

5 Ensembl transcripts including schematic representations:

ENST00000375383 ENST00000375379 ENST00000404049 ENST00000349663 ENST00000375401

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KDM5C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDM5C

¹ / ²

7 probe-sets matching KDM5C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54450_at²	U95-C	1	1.00	1.00	0.55	1.16	--	--	--	--	--
33268_at²	U95-A	2	1.00	0.91	0.73	0.99	--	--	--	--	--
47205_at²	U95-B	1	0.94	1.00	0.80	0.85	--	--	--	--	--
239207_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
202383_at²	U133-A	2	1.00	0.95	--	--	--	--	--	--	--
239207_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202383_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks KDM5C for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGTAATAAA

SOURCE GeneReport for Unigene cluster: Hs.631768
UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229
Tissue specificity: Expressed in all tissues examined. Highest levels found in brain and skeletal
muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for KDM5C gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JARID1C¹	--	jumonji, AT rich interactive domain 1C	93.19(n) 97.88(a)	491894 XM_549014.2 XP_549014.2
cow (Bos taurus)	JARID1C¹	--	jumonji, AT rich interactive domain 1C	92.99(n) 97.49(a)	281490 XM_001249760.1 XP_001249761.1
mouse (Mus musculus)	Kdm5c⁵ Jarid1c¹	X (64.00 cM)⁵	lysine (K)-specific demethylase 5C⁵ jumonji, AT rich interactive domain 1C (Rbp2 like)¹	90.16(n)¹ 95.36(a)¹	20591¹ NM_013668.2¹ NP_038696.1¹ AF039894⁵ AF127245⁵ (see all 26)
zebrafish (Danio rerio)	im:7158173¹	--	im:7158173	64.92(n) 67.59(a)	553406 XM_001920606.1 XP_001920641.1
baker's yeast (Saccharomyces cerevisiae)	JHD2(YJR119C)⁴	10(646480-644294)	JmjC domain family histone demethylase specific for more	--	853583 NP_012653.1

About this table Species with no ortholog for KDM5C

ENSEMBL Gene Tree for KDM5C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for KDM5C gene

ENSG00000117139² KDM5A² KDM5D²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/92 NCBI SNPs in KDM5C are shown (see all 92 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs942926^1,2	A,C,F,H	53272936(+)	`ATTACT/CTTGAA`	1	--	ng3¹ tfbs³		15	NA EA NS EU WA	1044
	rs1886889^1,2	A,C,F,H	53237561(+)	`CAGTAG/TATGGG`	1	--	ut3¹		13	NA EA EU WA	1080
	rs1886887^1,2	A,C,F,H	53273161(+)	`TCACAC/TGGATA`	1	--	ng3¹		9	NS EU EA WA	628
	rs1886888^1,2	A,C,F,H	53273305(+)	`gcccaG/Atgata`	1	--	ng3¹		4	EU EA WA	418
	rs3810737^1,2	C,F,H	53272016(-)	`ACAATC/AAAAGT`	1	--	ng3¹ tfbs³		8	EU EA WA	626
	rs3810736^1,2	F,H	53272157(-)	`AAAGTA/GCTGGT`	1	--	ng3¹ tfbs³		4	EU EA WA	418
	rs17002644^1,2	F,H	53238383(+)	`GTGAAG/ATTTCC`	1	--	ut3¹		7	NA EU EA WA	535
	rs35353912^1,2	F	53247833(+)	`GCACGG/AGGGAA`	1	P/P	syn¹		1	NA	74
	rs2025663^1,2	A,C,F,H,O	53253515(-)	`AGTTCA/GCCCCT`	1	--	int¹		7	NA EA EU WA	694
	rs2182285^1,2	A,C,F,H,O	53244068(+)	`TATACA/GTCTTT`	1	--	int¹		22	NA EA NS EU WA	1394

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HapMap Linkage Disequilibrium images for KDM5C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 314690

UniProtKB/Swiss-Prot: KDM5C_HUMAN, P41229

Defects in KDM5C are a cause of X-linked mental retardation (XLMR) [MIM:300534]. Mental

retardation is usually defined as cognitive impairment with an IQ less than 70. Etiologically,

mental retardation is a very heterogeneous condition that involves environmental, stochastic

and/or genetic factors

1 Novoseek disease relationship for KDM5C gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mental retardation	51.40	6	18697827 (4), 16538222 (1), 15586325 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/24 PubMed articles for KDM5C gene (see all 24 ):

Isolation and characterization of XE169, a novel human gene that escapes X-inactivation. (PubMed id 8162017)^{1, 2, 3, 4} Wu J....Shapiro L.J. (1994)
A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. (PubMed id 7951230)^{2, 3, 4} Agulnik A.I.... Bishop C.E. (1994)
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. (PubMed id 15586325)^{1, 3, 4} Jensen L.R.... Lenzner S. (2005)
A novel mutation in JARID1C gene associated with mental retardation. (PubMed id 16538222)^{1, 3, 4} Santos C....Mila M. (2006)
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (PubMed id 17320160)^{3, 4} Iwase S.... Shi Y. (2007)
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. (PubMed id 17468742)^{3, 4} Tahiliani M.... Shi Y. (2007)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Novel JARID1C/SMCX mutations in patients with X-linked mental retardation. (PubMed id 16541399)^{3, 4} Tzschach A.... Jensen L.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8242	HGNC: 11114	AceView: JARID1C	Ensembl:ENSG00000126012	euGenes: HUgn8242
ECgene: KDM5C	H-InvDB: KDM5C

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=JARID1C

Licensable Technologies for KDM5C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for KDM5C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDM5C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDM5C		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KDM5C		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (KDM5C / Jarid1C / SMCX)
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Antibodies for JARID1C

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KDM5C Gene at Home site.
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KDM5C Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for KDM5C

Summaries
for KDM5C

Genomic Location
for KDM5C

Proteins
for KDM5C

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Families
for KDM5C

Gene Function
for KDM5C

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for KDM5C

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDM5C (Gene Symbol)
DXS1272E
EC 1.14.11.-
JARID1C
MRXJ
MRXSJ
OTTHUMP00000023342
SMCX
XE169
Histone demethylase JARID1C
JmjC domain-containing protein SMCX
Jumonji, AT rich interactive domain 1C (RBP2-like)
Jumonji/ARID domain-containing protein 1C
Protein SmcX
Protein Xe169
Smcx homolog, X chromosome
Smcy homolog, X-linked
Smcy homolog, X-linked (mouse)
jumonji, AT rich interactive domain 1C
lysine (K)-specific demethylase 5C
lysine-specific demethylase 5C
selected cDNA on X

KDM5C Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor KDM5C

Summariesfor KDM5C

Genomic Locationfor KDM5C

Proteinsfor KDM5C

Protein Domains/Familiesfor KDM5C

Gene Functionfor KDM5C

Pathways & Interactionsfor KDM5C

Drugs & Compoundsfor KDM5C

Transcriptsfor KDM5C

Expression for KDM5C

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Genome Databases showing KDM5C

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Specialized Databases showing KDM5C

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDM5C

Summaries
for KDM5C

Genomic Location
for KDM5C

Proteins
for KDM5C

Protein Domains/
Families
for KDM5C

Gene Function
for KDM5C

Pathways & Interactions
for KDM5C

Drugs & Compounds
for KDM5C

Transcripts
for KDM5C

Expression
for KDM5C

Orthologs
for KDM5C

Paralogs
for KDM5C

SNPs/Variants
for KDM5C

Disorders & Mutations
for KDM5C

Medical News
for KDM5C

Publications
for KDM5C

Licensable Technologies
for KDM5C

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for KDM5C