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KDM5A Gene

protein-coding GIFtS: 51

GC12M000259

lysine (K)-specific demethylase 5A
(Previous names: retinoblastoma-binding protein 2, Jumonji, AT rich interactive domain 1A (RBBP2-like), jumonji, AT rich interactive domain 1A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RBBP2, JARID1A)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 1.14.11.- ^³
JARID1A ^², ³
RBBP-2 ^³
RBBP2 ^², ³
RBP2 ^², ³

Descriptions
Histone demethylase JARID1A ^³
Jumonji, AT rich interactive domain 1A (RBBP2-like) ^¹, ²
Jumonji, AT rich interactive domain 1A (RBP2-like) ^²
Jumonji/ARID domain-containing protein 1A ^³
Retinoblastoma-binding protein 2 ^¹, ², ³
jumonji, AT rich interactive domain 1A ^¹
lysine (K)-specific demethylase 5A ^²
lysine-specific demethylase 5A ^¹
retinoblastoma binding protein 2 ^²

External Ids
HGNC: 9886¹
Entrez Gene: 5927²
UniProtKB: P29375³
Ensembl: ENSG00000073614⁷

Search outside databases for aliases for KDM5A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for KDM5A:

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly,

with several other proteins, to retinoblastoma protein which regulates cell proliferation. This

protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell

leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded

protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this

protein. Alternatively spliced transcript variants encoding distinct isoforms have been found for

this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: KDM5A_HUMAN, P29375

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing

a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36',

H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3

'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in

transcriptional regulation of Hox proteins during cell differentiation. May participate in

transcriptional repression of cytokines such as CXCL12

Gene Wiki entry for KDM5A (JARID1A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p11

KDM5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M000259: (about GC identifiers)

Start:	259,484 bp from pter
End:	368,881 bp from pter
Size:	109,398 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009759.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: KDM5A_HUMAN, P29375 (See protein sequence)

Recommended Name: Lysine-specific demethylase 5A

Size: 1690 amino acids; 192095 Da

Cofactor: Fe(2+) (By similarity)

Subunit: Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and

LMO2

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=AAB28544.1; Type=Frameshift; Positions=Several;

PDB structures from and Proteopedia :

2JXJ (3D)

2KGG (3D)

2KGI (3D)

3GL6 (3D)

Secondary accessions: A8MV76 Q4LE72 Q86XZ1

Alternative splicing: 2 isoforms: P29375-1 P29375-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001036068.1 NP_005047.2

ENSEMBL proteins:

ENSP00000382687 ENSP00000261253 ENSP00000382688 ENSP00000372265

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KDM5A / Jarid1A / RBBP2)
	Human Recombinant Proteins from Abnova (JARID1A)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	8414517
GO:0005737	cytoplasm	IDA	18029348
GO:0019907	colocalizes with cyclin-dependent protein kinase activating kinase holoenzyme complex	IDA	11445587

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Antibodies for KDM5A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for KDM5A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KDM5A / Jarid1A / RBBP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (JARID1A)
	Novus Biologicals Antibodies for JARID1A

Assays for KDM5A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P29375

ProtoNet protein and cluster: P29375

5/6 Blocks protein families (see all 6 ):

IPB001606 ARID (AT-rich interaction domain) protein

IPB001965 Zn-finger-like

IPB003347 Transcription factor jumonji

IPB003349 Transcription factor jumonji

IPB004198 Zn-finger

UniProtKB/Swiss-Prot: KDM5A_HUMAN, P29375

Similarity: Belongs to the JARID1 histone demethylase family

Similarity: Contains 1 ARID domain

Similarity: Contains 1 JmjC domain

Similarity: Contains 1 JmjN domain

Similarity: Contains 3 PHD-type zinc fingers

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JARID1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005056

Applied Biosystems Silencer® siRNAs for KDM5A

Sigma-Aldrich siRNA and siRNA Panels for KDM5A

Sigma-Aldrich shRNA Panels and shRNA for KDM5A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042603
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042603
untagged cDNA clones in CMV expression vector (see all 2): NM_001042603

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001042603

UniProtKB/Swiss-Prot: KDM5A_HUMAN, P29375

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing

a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36',

H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3

'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in

transcriptional regulation of Hox proteins during cell differentiation. May participate in

transcriptional repression of cytokines such as CXCL12

Enzyme Number (IUBMB): EC 1.14.11.-

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	8414517
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	TAS	1857421
GO:0008270	zinc ion binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for KDM5A

5/11 Interacting proteins for KDM5A (ENSP00000372265³) via UniProtKB, MINT, and/or STRING (see all 11 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RB1	ENSP00000267163³	STRING (score=.995)
ERCC2	ENSP00000221481³	STRING (score=.899)
HOXC10	ENSP00000307321³	STRING (score=.899)
HSPD1P4	ENSP00000340019³	STRING (score=.899)
PUF60	ENSP00000322016³	STRING (score=.899)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	8414517
GO:0007275	multicellular organismal development	IEA	--
GO:0016568	chromatin modification	IEA	--
GO:0045941	positive regulation of transcription	IDA	11358960

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for KDM5A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (KDM5A)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (JARID1A)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_005056

Sigma-Aldrich siRNA and siRNA Panels for KDM5A

Sigma-Aldrich shRNA Panels and shRNA for KDM5A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001042603 NM_005056

REFSEQ mRNAs for KDM5A gene (2 alternative transcripts):

NM_001042603.1 NM_005056.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001042603 NM_005056

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042603
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042603
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001042603

Additional cDNA sequence:

AB209999.1 AF007135.1 AK057703.1 AK225060.1 AK301150.1 AK301273.1 AK307580.1 AK307689.1

AL133026.1 BC048307.1 BC053893.1 BC110916.1 S66431.1

15 DOTS entries:

DT.100780845 DT.87016210 DT.75163122 DT.92044835 DT.110527 DT.100780847 DT.100727224 DT.431815

DT.95331495 DT.121126262 DT.121126263 DT.121126329 DT.121126345 DT.87000478 DT.97785624

24/416 AceView cDNA sequences (see all 416 ):

BC022392 BX106636 BU180941 AI492362 AI146438 AW058576 BM833997 AA470104

AI696637 BC020867 AW292586 BQ632596 AW468600 AK057703 BU739431 BQ956136

H06876 BE301184 AW131815 AA809989 BE044209 BX441976 BM969065 AA812025

Unigene Cluster for KDM5A:

Lysine (K)-specific demethylase 5A

Hs.76272 [show with all ESTs]

Unigene Representative Sequence: NM_005056

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KDM5A (see all 7 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^	23	^	24a	·
SP1:																											-
SP2:
SP3:
SP4:
SP5:

ExUns:	24b	^	25	^	26	^	27a	·	27b	·	27c	^	28	^	29	^	30
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for KDM5A

4 Ensembl transcripts including schematic representations:

ENST00000399787 ENST00000261253 ENST00000399788 ENST00000382815

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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KDM5A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for KDM5A

¹ / ²

14 probe-sets matching KDM5A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
54023_at²	U95-B	1	1.00	1.00	0.93	1.30	--	--	--	--	--
1785_at²	U95-A	1	1.00	1.00	0.97	0.99	--	--	--	--	--
57505_at²	U95-B	1	1.00	1.00	0.91	1.05	--	--	--	--	--
36999_at²	U95-A	1	1.00	1.00	0.64	0.66	--	--	--	--	--
230226_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
202040_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
226367_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
215698_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
226371_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
230226_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202040_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226367_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215698_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226371_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks KDM5A for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.76272

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for KDM5A gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JARID1A¹	--	jumonji, AT rich interactive domain 1A	91.52(n) 96(a)	477727 XM_849597.1 XP_854690.1
cow (Bos taurus)	JARID1A¹	--	jumonji, AT rich interactive domain 1A	89.92(n) 97.81(a)	507962 XM_584665.3 XP_584665.2
mouse (Mus musculus)	Kdm5a⁵ Jarid1a¹	6 (54.00 cM)⁵	lysine (K)-specific demethylase 5A⁵ jumonji, AT rich interactive domain 1A (Rbp2 like)¹	91.74(n)¹ 96.69(a)¹	214899¹ XM_359326.6¹ XP_359326.5¹ AA119824⁵ AA409370⁵ (see all 31)
chicken (Gallus gallus)	JARID1A¹	--	jumonji, AT rich interactive domain 1A	80.5(n) 92.18(a)	418148 XM_416379.2 XP_416379.2
fruit fly (Drosophila melanogaster)	lid¹	--	little imaginal discs	50.68(n) 46.4(a)	33837 NM_078762.4 NP_523486.1

About this table Species with no ortholog for KDM5A

ENSEMBL Gene Tree for KDM5A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for KDM5A gene

KDM5C² ENSG00000117139² KDM5D²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/589 NCBI SNPs in KDM5A are shown (see all 589 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 160)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12317905^1,2	A,C,F,H	259138(+)	`AGGAAG/ACCAAG`	2	--	ng5¹		7		EU EA WA NA	554
	rs11062385^1,2	C,F,H	297836(-)	`CATGAT/CGGATG`	2	T/M	mis¹		9		EU EA WA NA	868
	rs16929135^1,2	F,H	259275(+)	`ACCTTT/CTTTGA`	2	--	ng5¹		8		NA EU EA WA	634
	rs1043599^1,2	F,H	261712(-)	`AGGTGC/AAGTAG`	2	--	ut3¹		5		MN EU EA WA	602
	rs16929151^1,2	F,H	262733(+)	`CGTTAG/CCTTGG`	2	--	ut3¹		7		NA EU EA WA	560
	rs16929140^1,2	F,H	260062(+)	`TCTCTG/AAAGTA`	2	--	ut3¹		7		NA EU EA WA	558
	rs2229353^1,2	F,H	287243(-)	`GTGTTC/GCTCTT`	2	P/A	mis¹ trp³		5		MN EU EA WA	474
	rs16929148^1,2	F,H	262477(+)	`AAAACG/ATCAGA`	2	--	ut3¹		7		NA EU EA WA	562
--	rs9668495^1,2	A,C	368998(+)	`AGGCGC/GAACGA`	2	--	ng3¹ tfbs³		0	--	--	--	--
	rs12578155^1,2	F,H	259160(+)	`ATAAGC/GAACTA`	2	--	ng5¹		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for KDM5A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 180202

1 Novoseek disease relationship for KDM5A gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	76.83	11	10942599 (1), 7935440 (1), 8530100 (1), 16419055 (1) (see all 8)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/35 PubMed articles for KDM5A gene (see all 35 ):

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PubMed id 1857421)^{1, 2, 3, 4} Defeo-Jones D.... Oliff A. (1991)
Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription. (PubMed id 11358960)^{1, 3, 4} Chan S.W. and Hong W. (2001)
T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2. (PubMed id 9129143)^{1, 3, 4} Mao S.... Goorha R.M. (1997)
Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. (PubMed id 7935440)^{1, 3, 4} Kim Y.W.... Kaye F.J. (1994)
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. (PubMed id 17320161)^{3, 4} Christensen J.... Helin K. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. (PubMed id 15949438)^{3, 4} Benevolenskaya E.V....Kaelin W.G. Jr. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (PubMed id 8414517)^{3, 4} Fattaey A.R....Jones R.E. (1993)
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. (PubMed id 17573780)^{1, 3} Hayakawa T....Nakayama J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5927	HGNC: 9886	AceView: JARID1AandSLC6A13	Ensembl:ENSG00000073614	euGenes: HUgn5927
ECgene: KDM5A	H-InvDB: KDM5A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for KDM5A	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for KDM5A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for KDM5A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for KDM5A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for KDM5A		Antibodies for KDM5A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for KDM5A		Browse small molecules at Sigma-Aldrich
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	Antibodies		Primer Pairs
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	Recombinant Proteins (JARID1A)
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	Recombinant Proteins (KDM5A / Jarid1A / RBBP2)
	Antibodies (KDM5A / Jarid1A / RBBP2)

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Antibodies for JARID1A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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KDM5A Gene at Home site.
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KDM5A Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for KDM5A

Summaries
for KDM5A

Genomic Location
for KDM5A

Proteins
for KDM5A

Protein Domains/
Families
for KDM5A

Gene Function
for KDM5A

Pathways & Interactions
for KDM5A

Drugs & Compounds
for KDM5A

Transcripts
for KDM5A

Expression
for KDM5A

Orthologs
for KDM5A

Paralogs
for KDM5A

SNPs/Variants
for KDM5A

Disorders & Mutations
for KDM5A

Medical News
for KDM5A

Publications
for KDM5A

Search for KDM5A

Genome Databases showing KDM5A

Other Databases showing KDM5A

Specialized Databases showing KDM5A

Licensable Technologies
for KDM5A

Services
for KDM5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

KDM5A Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor KDM5A

Summariesfor KDM5A

Genomic Locationfor KDM5A

Proteinsfor KDM5A

Protein Domains/Familiesfor KDM5A

Gene Functionfor KDM5A

Pathways & Interactionsfor KDM5A

Drugs & Compoundsfor KDM5A

Transcriptsfor KDM5A

Expression for KDM5A

Orthologsfor KDM5A

Paralogsfor KDM5A

SNPs/Variantsfor KDM5A

Disorders & Mutationsfor KDM5A

Medical Newsfor KDM5A

Publicationsfor KDM5A

Search for KDM5A

Genome Databases showing KDM5A

Other Databases showing KDM5A

Specialized Databases showing KDM5A

Licensable Technologiesfor KDM5A

Servicesfor KDM5A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for KDM5A

Summaries
for KDM5A

Genomic Location
for KDM5A

Proteins
for KDM5A

Protein Domains/
Families
for KDM5A

Gene Function
for KDM5A

Pathways & Interactions
for KDM5A

Drugs & Compounds
for KDM5A

Transcripts
for KDM5A

Expression
for KDM5A

Orthologs
for KDM5A

Paralogs
for KDM5A

SNPs/Variants
for KDM5A

Disorders & Mutations
for KDM5A

Medical News
for KDM5A

Publications
for KDM5A

Licensable Technologies
for KDM5A

Services
for KDM5A