Aliases for JAML Gene
Aliases for JAML Gene
External Ids for JAML Gene
- HGNC: 19084
- Entrez Gene: 120425
- Ensembl: ENSG00000160593
- OMIM: 609770
- UniProtKB: Q86YT9
Previous HGNC Symbols for JAML Gene
- AMICA1
Summaries for JAML Gene
GeneCards Summary for JAML Gene
JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System.
UniProtKB/Swiss-Prot for JAML Gene
-
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAML Gene
Genomics for JAML Gene
GeneHancer (GH) Regulatory Elements for JAML Gene
Regulatory Element Products
Genomic Locations for JAML Gene
- chr11:118,193,727-118,225,094
- (GRCh38/hg38)
- Size:
- 31,368 bases
- Orientation:
- Minus strand
- chr11:118,064,442-118,095,809
- (GRCh37/hg19)
Genomic View for JAML Gene
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC


RefSeq DNA sequence for JAML Gene
Proteins for JAML Gene
-
Protein details for JAML Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YT9-JAML_HUMAN
- Recommended name:
- Junctional adhesion molecule-like
- Protein Accession:
- Q86YT9
- B0YIV1
- B0YIV2
- Q496M1
- Q5DTC6
- Q7Z499
- Q8N9I7
- Q8NF70
Protein attributes for JAML Gene
- Size:
- 394 amino acids
- Molecular mass:
- 44339 Da
- Quaternary structure:
-
- Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
- SequenceCaution:
-
- Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Post-translational modifications for JAML Gene
Other Protein References for JAML Gene
Antibody Products
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-
Abcam antibodies for JAML
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Protein Products
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-
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-
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-
Abcam proteins for JAML
Assay Products
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-
Quality Products:
- Sino Biological Assays for JAML
No data available for DME Specific Peptides for JAML Gene
Domains & Families for JAML Gene
Gene Families for JAML Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for JAML Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for JAML Gene
Graphical View of Domain Structure for InterPro Entry
Q86YT9UniProtKB/Swiss-Prot:
JAML_HUMAN :- The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
- Belongs to the immunoglobulin superfamily.
- Domain:
-
- The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
- Family:
-
- Belongs to the immunoglobulin superfamily.
Function for JAML Gene
Molecular function for JAML Gene
- UniProtKB/Swiss-Prot Function:
- Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.
Phenotypes From GWAS Catalog for JAML Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | IPI | 12869515 |
GO:0042803 | protein homodimerization activity | IDA | 12869515 |
GO:0050839 | cell adhesion molecule binding | IPI | 12869515 |
Phenotypes for JAML Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for JAML gene
-
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CRISPR Products
-
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- Overview of 98 available JAML gene related products
- Applied Biological Materials CRISPR for JAML
-
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- GenScript: Design CRISPR guide RNA sequences for JAML
miRNA for JAML Gene
- miRTarBase miRNAs that target JAML
miRNA Products
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Inhibitory RNA Products
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- Overview of 98 available JAML gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for JAML gene
Clone Products
- Sino Biological Human cDNA Clone for JAML
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for JAML
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for JAML (AMICA/JAML)
Cell Line Products
-
Horizon Cell Lines for JAML
-
ViGene Biosciences adenoviral particle packaged cDNA for JAML gene
-
ViGene Biosciences lentiviral particle packaged cDNA for JAML gene
-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAML Gene
Localization for JAML Gene
Subcellular locations from UniProtKB/Swiss-Prot for JAML Gene
- Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0005923 | bicellular tight junction | IDA | 15800062 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0030054 | cell junction | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for JAML Gene
Pathways & Interactions for JAML Gene
Pathways by source for JAML Gene
Interacting Proteins for JAML Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IEA | -- |
GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | IMP | 18948633 |
GO:0030593 | neutrophil chemotaxis | IMP | 15800062 |
GO:0035696 | monocyte extravasation | IMP | 18948633 |
GO:0046629 | gamma-delta T cell activation | ISS,IEA | -- |
No data available for SIGNOR curated interactions for JAML Gene
Transcripts for JAML Gene
mRNA/cDNA for JAML Gene
- (8) REFSEQ mRNAs :
- (89) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for JAML
- genomics-online: gRNA clones - Search results for 98 available JAML gene related products
- Overview of 98 available JAML gene related products
- Applied Biological Materials CRISPR for JAML
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for JAML
miRNA Products
- Search ViGene Biosciences for JAML
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for JAML
- Browse OriGene Inhibitory RNA Products For JAML
- genomics-online: shRNA clones - Search results for 98 available JAML gene related products
- Overview of 98 available JAML gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for JAML gene
Clone Products
- Sino Biological Human cDNA Clone for JAML
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for JAML
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JAML
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for JAML
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for JAML (AMICA/JAML)
Expression for JAML Gene
NURSA nuclear receptor signaling pathways regulating expression of JAML Gene:
JAMLmRNA Expression by UniProt/SwissProt for JAML Gene:
Q86YT9-JAML_HUMANEvidence on tissue expression from TISSUES for JAML Gene
- Blood(4.5)
- Lymph node(4.4)
- Spleen(4.4)
- Bone marrow(4.2)
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for JAML
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAML Gene
Orthologs for JAML Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | AMICA1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | AMICA1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | AMICA1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Amica1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Amica1 33 34 |
|
||
Jaml 16 |
|
||||
chicken (Gallus gallus) |
Aves | AMICA1 34 |
|
OneToOne |
- Species where no ortholog for JAML was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for JAML Gene
No data available for Paralogs for JAML Gene
Variants for JAML Gene
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000033150 | -- | 118,213,787(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000104794 | -- | 118,214,136(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000145497 | -- | 118,221,245(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
rs1000352345 | -- | 118,217,503(-) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000390697 | -- | 118,220,607(-) | C/T | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3579923 | CNV | loss | 25503493 |
esv3627867 | CNV | loss | 21293372 |
nsv511 | CNV | insertion | 18451855 |
nsv952742 | CNV | duplication | 24416366 |
Additional Variant Information for JAML Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- JAML
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAML Gene
Disorders for JAML Gene
Additional Disease Information for JAML
No disorders were found for JAML Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAML Gene
Publications for JAML Gene
- Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PMID: 18948633) Guo YL … Zen K (Arteriosclerosis, thrombosis, and vascular biology 2009) 3 4 22 58
- Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. (PMID: 15800062) Zen K … Parkos CA (Molecular biology of the cell 2005) 3 4 22 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PMID: 12869515) Moog-Lutz C … Lutz PG (Blood 2003) 3 4 22 58
- JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. (PMID: 19064666) Luissint AC … Bourdoulous S (The Journal of cell biology 2008) 3 4 58
Products for JAML Gene
- R&D Systems Antibodies for JAML (AMICA/JAML)
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- Browse Primary Antibodies
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- Browse ELISAs
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for JAML
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for JAML
- VectorBuilder custom plasmid, inducible vectors for JAML
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for JAML
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available JAML Antibodies ranked by validation data
- Compare Top JAML Antibodies
- antibodies-online: Search results for 3 available JAML Elisa Kits ranked by validation data
- Compare Top JAML Elisa Kits
- Quality Products:
- antibodies-online: Search results for 9 available JAML Proteins ranked by validation data
- Compare Top JAML Proteins
- Quality Products:
- Search GeneTex for Antibodies for JAML
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- ViGene Biosciences adenoviral particle packaged cDNA for JAML gene
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- Horizon Cell Lines for JAML
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- Overview of 98 available JAML gene related products
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- Overview of 98 available JAML gene related products
- genomics-online: shRNA clones - Search results for 98 available JAML gene related products
- Overview of 98 available JAML gene related products
Sources for JAML Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew