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JAML Gene(Protein Coding)

Junction Adhesion Molecule Like

GCID:
GC11M118195
GIFtS:
37
Genes Participants
UDN Logo

Aliases for JAML Gene

Aliases for JAML Gene

  • Junction Adhesion Molecule Like 2 3 5
  • Adhesion Molecule Interacting With CXADR Antigen 1 3 4
  • Adhesion Molecule, Interacts With CXADR Antigen 1 2 3
  • AMICA1 3 4
  • Dendritic-Cell Specific Protein CREA7-1 3
  • Dendritic-Cell Specific Protein CREA7-4 3
  • Dendritic Cell-Specific Protein CREA7-1 4
  • Junctional Adhesion Molecule-Like 3
  • Adhesion Molecule AMICA 3
  • CREA7-1 3
  • CREA7-4 3
  • AMICA 3
  • Gm638 3

External Ids for JAML Gene

Previous HGNC Symbols for JAML Gene

  • AMICA1

Summaries for JAML Gene

GeneCards Summary for JAML Gene

JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System.

UniProtKB/Swiss-Prot for JAML Gene

  • Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene Wiki entry for JAML Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAML Gene

Genomics for JAML Gene

Products:

  1. Regulatory Element

Regulatory Elements for JAML Gene

Enhancers for JAML Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G118238 2 FANTOM5 Ensembl ENCODE dbSUPER 32.3 -15.5 -15468 5.1 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF207 FOS SP5 ZHX2 JUNB JAML MPZL3 ENSG00000254909 ENSG00000254428 RPL23AP64 UBE4A CD3E IL10RA BCL9L ARCN1
GH11G118210 1.6 Ensembl ENCODE dbSUPER 15.9 +10.7 10711 8.0 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 FOS TBX21 MPZL3 JAML CD3G CD3D CD3E MPZL2 GC11M118201 HSPE1P18
GH11G118194 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +30.0 30021 2.1 HNRNPUL1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 PPARG KAT8 MIER3 JAML MPZL3 MPZL2 HSPE1P18 SCN2B
GH11G118200 1.3 ENCODE dbSUPER 17.6 +22.8 22760 3.7 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 TCF12 FOS PAF1 SP5 JAML MPZL3 MPZL2 TRAPPC4 HSPE1P18 SCN2B
GH11G118198 1.4 Ensembl ENCODE dbSUPER 15.4 +26.3 26329 0.9 ELF3 RB1 WRNIP1 DMAP1 ZNF48 RAD21 SLC30A9 GLIS2 ZNF143 KLF13 JAML MPZL2 HSPE1P18 SCN2B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JAML on UCSC Golden Path with GeneCards custom track

Promoters for JAML Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045604 694 401 RAD51 ZNF24

Genomic Location for JAML Gene

Chromosome:
11
Start:
118,193,727 bp from pter
End:
118,225,094 bp from pter
Size:
31,368 bases
Orientation:
Minus strand

Genomic View for JAML Gene

Genes around JAML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAML Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for JAML Gene

Proteins for JAML Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for JAML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT9-JAML_HUMAN
    Recommended name:
    Junctional adhesion molecule-like
    Protein Accession:
    Q86YT9
    Secondary Accessions:
    • B0YIV1
    • B0YIV2
    • Q496M1
    • Q5DTC6
    • Q7Z499
    • Q8N9I7
    • Q8NF70

    Protein attributes for JAML Gene

    Size:
    394 amino acids
    Molecular mass:
    44339 Da
    Quaternary structure:
    • Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
    SequenceCaution:
    • Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for JAML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAML Gene

Post-translational modifications for JAML Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JAML Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for JAML Gene

Domains & Families for JAML Gene

Gene Families for JAML Gene

HGNC:

Protein Domains for JAML Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for JAML Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YT9

UniProtKB/Swiss-Prot:

JAML_HUMAN :
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAML: view

Function for JAML Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for JAML Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.

Gene Ontology (GO) - Molecular Function for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 12869515
GO:0042803 protein homodimerization activity IDA 12869515
GO:0050839 cell adhesion molecule binding IPI 12869515
genes like me logo Genes that share ontologies with JAML: view
genes like me logo Genes that share phenotypes with JAML: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JAML

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAML Gene

Localization for JAML Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAML Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAML gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005923 bicellular tight junction IDA 15800062
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with JAML: view

Pathways & Interactions for JAML Gene

genes like me logo Genes that share pathways with JAML: view

Interacting Proteins for JAML Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348635%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000380227%0d%0a9606.ENSP00000284878%0d%0a
Selected Interacting proteins: ENSP00000348635 Q86YT9-JAML_HUMAN for JAML Gene via STRING IID

Gene Ontology (GO) - Biological Process for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18948633
GO:0030593 neutrophil chemotaxis IMP 15800062
GO:0035696 monocyte extravasation IMP 18948633
GO:0046629 gamma-delta T cell activation ISS,IEA --
genes like me logo Genes that share ontologies with JAML: view

No data available for SIGNOR curated interactions for JAML Gene

Drugs & Compounds for JAML Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for JAML Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for JAML Gene

(8) REFSEQ mRNAs :
(89) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAML Gene

No ASD Table

Relevant External Links for JAML Gene

GeneLoc Exon Structure for
JAML
ECgene alternative splicing isoforms for
JAML

Expression for JAML Gene

Products:

  1. Primer

NURSA nuclear receptor signaling pathways regulating expression of JAML Gene:

JAML

mRNA Expression by UniProt/SwissProt for JAML Gene:

Q86YT9-JAML_HUMAN
Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

Evidence on tissue expression from TISSUES for JAML Gene

  • Blood(4.5)
  • Lymph node(4.4)
  • Spleen(4.4)
  • Bone marrow(4.2)
  • Nervous system(4.2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAML Gene

Orthologs for JAML Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAML Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia AMICA1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
 Mammalia AMICA1 34 35
  • 82.11 (n)
cow
(Bos Taurus)
 Mammalia AMICA1 34 35
  • 79.63 (n)
rat
(Rattus norvegicus)
 Mammalia Amica1 34
  • 72.04 (n)
mouse
(Mus musculus)
 Mammalia Amica1 34 35
  • 69.91 (n)
Jaml 16
chicken
(Gallus gallus)
 Aves AMICA1 35
  • 26 (a)
 OneToOne
Species where no ortholog for JAML was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JAML Gene

ENSEMBL:
Gene Tree for JAML (if available)
TreeFam:
Gene Tree for JAML (if available)

Paralogs for JAML Gene

No data available for Paralogs for JAML Gene

Variants for JAML Gene

Sequence variations from dbSNP and Humsavar for JAML Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000033150 -- 118,213,787(+) TGCCA(C/T)CAAGT intron-variant, upstream-variant-2KB
rs1000104794 -- 118,214,136(+) AACTA(C/T)ATCCA intron-variant, upstream-variant-2KB
rs1000145497 -- 118,221,245(+) TAAAA(C/T)CCTTT intron-variant
rs1000352345 -- 118,217,503(+) AATTA(C/T)TAAAA intron-variant, upstream-variant-2KB
rs1000390697 -- 118,220,607(+) TCGAT(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAML Gene

Variant ID Type Subtype PubMed ID
esv3579923 CNV loss 25503493
esv3627867 CNV loss 21293372
nsv511 CNV insertion 18451855
nsv952742 CNV duplication 24416366

Variation tolerance for JAML Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JAML Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JAML

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAML Gene

Disorders for JAML Gene

Relevant External Links for JAML

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JAML
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JAML

No disorders were found for JAML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAML Gene

Publications for JAML Gene

  1. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PMID: 18948633) Guo Y.L. … Zen K. (Arterioscler. Thromb. Vasc. Biol. 2009) 3 4 22 64
  2. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PMID: 15800062) Zen K. … Parkos C.A. (Mol. Biol. Cell 2005) 3 4 22 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  4. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PMID: 12869515) Moog-Lutz C. … Lutz P.G. (Blood 2003) 3 4 22 64
  5. JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. (PMID: 19064666) Luissint A.C. … Bourdoulous S. (J. Cell Biol. 2008) 3 4 64

Products for JAML Gene

Sources for JAML Gene

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