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JAML Gene(Protein Coding)

Junction Adhesion Molecule Like

GCID:
GC11M118195
GIFtS:
35
Genes Participants
UDN Logo

Aliases for JAML Gene

Aliases for JAML Gene

  • Junction Adhesion Molecule Like 2 3 5
  • Adhesion Molecule Interacting With CXADR Antigen 1 3 4
  • Adhesion Molecule, Interacts With CXADR Antigen 1 2 3
  • AMICA1 3 4
  • Dendritic-Cell Specific Protein CREA7-1 3
  • Dendritic-Cell Specific Protein CREA7-4 3
  • Dendritic Cell-Specific Protein CREA7-1 4
  • Adhesion Molecule AMICA 3
  • CREA7-1 3
  • CREA7-4 3
  • AMICA 3
  • Gm638 3

External Ids for JAML Gene

Previous HGNC Symbols for JAML Gene

  • AMICA1

Summaries for JAML Gene

GeneCards Summary for JAML Gene

JAML (Junction Adhesion Molecule Like) is a Protein Coding gene. Among its related pathways are Immune System and Platelet activation, signaling and aggregation.

UniProtKB/Swiss-Prot for JAML Gene

  • Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene Wiki entry for JAML Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAML Gene

Genomics for JAML Gene

Products:

  1. Regulatory Element

Regulatory Elements for JAML Gene

Enhancers for JAML Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JAML on UCSC Golden Path with GeneCards custom track

Promoters for JAML Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JAML on UCSC Golden Path with GeneCards custom track

Genomic Location for JAML Gene

Chromosome:
11
Start:
118,193,727 bp from pter
End:
118,225,094 bp from pter
Size:
31,368 bases
Orientation:
Minus strand

Genomic View for JAML Gene

Genes around JAML on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAML Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAML Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for JAML Gene

Proteins for JAML Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for JAML Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YT9-JAML_HUMAN
    Recommended name:
    Junctional adhesion molecule-like
    Protein Accession:
    Q86YT9
    Secondary Accessions:
    • B0YIV1
    • B0YIV2
    • Q496M1
    • Q5DTC6
    • Q7Z499
    • Q8N9I7
    • Q8NF70

    Protein attributes for JAML Gene

    Size:
    394 amino acids
    Molecular mass:
    44339 Da
    Quaternary structure:
    • Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
    SequenceCaution:
    • Sequence=BAC03390.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for JAML Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAML Gene

Proteomics data for JAML Gene at MOPED

Post-translational modifications for JAML Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JAML Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for JAML Gene

Domains & Families for JAML Gene

Gene Families for JAML Gene

HGNC:

Protein Domains for JAML Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for JAML Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YT9

UniProtKB/Swiss-Prot:

JAML_HUMAN :
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
  • Belongs to the immunoglobulin superfamily.
Domain:
  • The Ig-like V-type domain 1 mediates interaction with CXADR (By similarity). The Ig-like V-type domain 2 may also play a role in the interaction (PubMed:15800062).
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAML: view

Function for JAML Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for JAML Gene

UniProtKB/Swiss-Prot Function:
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells.

Gene Ontology (GO) - Molecular Function for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 12869515
genes like me logo Genes that share ontologies with JAML: view

Phenotypes for JAML Gene

GenomeRNAi human phenotypes for JAML:
genes like me logo Genes that share phenotypes with JAML: view

Animal Model Products

  • Taconic Biosciences Mouse Models for JAML

miRNA for JAML Gene

miRTarBase miRNAs that target JAML

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAML Gene

Localization for JAML Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAML Gene

Cell membrane; Single-pass type I membrane protein. Cell junction. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for JAML Gene

Pathways & Interactions for JAML Gene

genes like me logo Genes that share pathways with JAML: view

Interacting Proteins for JAML Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348635%0d%0a9606.ENSP00000303351%0d%0a9606.ENSP00000380227%0d%0a9606.ENSP00000284878%0d%0a
Selected Interacting proteins: ENSP00000348635 for JAML Gene via STRING

Gene Ontology (GO) - Biological Process for JAML Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0046629 gamma-delta T cell activation IEA,ISS --
GO:0050776 regulation of immune response TAS --
GO:0050900 leukocyte migration IEA,TAS --
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing ISS --
genes like me logo Genes that share ontologies with JAML: view

No data available for SIGNOR curated interactions for JAML Gene

Drugs & Compounds for JAML Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for JAML Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for JAML Gene

(7) REFSEQ mRNAs :
(89) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAML Gene

No ASD Table

Relevant External Links for JAML Gene

GeneLoc Exon Structure for
JAML
ECgene alternative splicing isoforms for
JAML

Expression for JAML Gene

Products:

  1. Primer

mRNA Expression by UniProt/SwissProt for JAML Gene

Q86YT9-JAML_HUMAN
Tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for JAML Gene

Orthologs for JAML Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAML Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia AMICA1 35
  • 79.63 (n)
  • 69.19 (a)
AMICA1 36
  • 69 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia AMICA1 35
  • 82.11 (n)
  • 73.09 (a)
AMICA1 36
  • 69 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Amica1 35
  • 69.91 (n)
  • 60.74 (a)
Amica1 16
Amica1 36
  • 57 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia AMICA1 35
  • 99.49 (n)
  • 98.98 (a)
AMICA1 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Amica1 35
  • 72.04 (n)
  • 64.52 (a)
chicken
(Gallus gallus)
 Aves AMICA1 36
  • 26 (a)
 OneToOne
Species with no ortholog for JAML:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for JAML Gene

ENSEMBL:
Gene Tree for JAML (if available)
TreeFam:
Gene Tree for JAML (if available)

Paralogs for JAML Gene

No data available for Paralogs for JAML Gene

Variants for JAML Gene

Sequence variations from dbSNP and Humsavar for JAML Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17121881 - 118,210,630(+) ATAAG(A/T)TGTCC nc-transcript-variant, reference, missense
rs1793174 - 118,203,622(+) ACTCC(A/G)CAGAC nc-transcript-variant, reference, missense
rs2298831 - 118,198,037(+) TCTTT(C/T)ATCTC nc-transcript-variant, reference, missense
rs590580 -- 118,195,389(+) CTGGT(A/G)CGATA intron-variant
rs605560 -- 118,196,472(+) GTCCT(C/G)CCTGC intron-variant, downstream-variant-500B

Variation tolerance for JAML Gene

Residual Variation Intolerance Score: 88.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.56; 77.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for JAML Gene

Disorders for JAML Gene

Relevant External Links for JAML

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JAML
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JAML

No disorders were found for JAML Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAML Gene

Publications for JAML Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. (PMID: 18948633) Guo Y.L. … Zen K. (Arterioscler. Thromb. Vasc. Biol. 2009) 3 23
  3. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial CAR and a JAM-like protein on neutrophils. (PMID: 15800062) Zen K. … Parkos C.A. (Mol. Biol. Cell 2005) 3 23
  4. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. (PMID: 12869515) Moog-Lutz C. … Lutz P.G. (Blood 2003) 3 23
  5. A secreted protein microarray platform for extracellular protein interaction discovery. (PMID: 21982860) Ramani S.R. … Gonzalez L.C. (Anal. Biochem. 2012) 3

Products for JAML Gene

Sources for JAML Gene

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