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Aliases & Descriptions for JAM3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ14529 2 | | JAM-2 3 | | JAM-3 3 | | JAM-C 1, 2, 3 | | JAMC 1, 2 |
| | | Descriptions |
|---|
| junctional adhesion molecule 3 2, 3 | | junctional adhesion molecule C 2 |
|
| | Search outside databases for aliases for JAM3 genePrevious GC identifers: GC11P136435 GC11P135453 GC11P133972 GC11P133476 |
Summaries for JAM3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for JAM3: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. [provided by RefSeq] UniProtKB/Swiss-Prot: JAM3_HUMAN, Q9BX67Function: May participate in cell-cell adhesion distinct from tight junctionsGene Wiki entry for JAM3 |
Genomic Location for JAM3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the JAM3 gene 
Entrez Gene cytogenetic band: 11q25 Ensembl cytogenetic band: 11q25 HGNC cytogenetic band: 11q25JAM3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P133444:
(about GC identifiers)
Start:
|
133,444,030 bp from pter |
End:
|
133,526,861 bp from pter |
Size:
|
82,832 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033899.7
| Proteins for JAM3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: JAM3_HUMAN, Q9BX67 (See
protein sequence)Recommended Name: Junctional adhesion molecule C precursor Size: 310 amino acids; 35020 Da
Subunit: Interacts with JAM2
Subcellular location: Cell membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q8WWL8 Q96FL1REFSEQ proteins: NP_116190.2
ENSEMBL proteins: ENSP00000299106
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for JAM3: Assays for JAM3: | Protein
Domains/ Families for JAM3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BX67
ProtoNet protein and cluster: Q9BX67 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: JAM3_HUMAN, Q9BX67Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for JAM3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032801
Applied Biosystems Silencer® siRNAs for JAM3
Sigma-Aldrich siRNA and siRNA Panels for JAM3  Sigma-Aldrich shRNA for JAM3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032801                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032801                                  untagged cDNA clone in CMV expression vector: NM_032801 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032801
UniProtKB/Swiss-Prot: JAM3_HUMAN, Q9BX67Function: May participate in cell-cell adhesion distinct from tight junctions8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Jam3):
| Pathways & Interactions for JAM3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for JAM3 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for JAM3 
5/37 Interacting proteins for JAM3 (ENSP000002991063 Q9BX672) via UniProtKB, MINT, and/or STRING (see all 37
)About this table
|
Drugs & Compounds for JAM3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for JAM3
|
Transcripts for JAM3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032801
Sigma-Aldrich siRNA and siRNA Panels for JAM3  Sigma-Aldrich shRNA for JAM3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_032801 REFSEQ mRNAs for JAM3 gene: NM_032801.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032801               OriGene GFP tagged cDNA clone in CMV expression vector: NM_032801                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032801                                  untagged cDNA clone in CMV expression vector: NM_032801  Additional cDNA sequence: AF356518.1 AF448478.1 AJ344431.1 AJ416101.1 AK027435.1 AK074769.1 AK075309.1 AK125071.1 AK225666.1 AY358335.1 BC010690.1 BC012147.1 BC057284.1 BC063031.1 CR601575.1 CR609180.1 CR612469.1 CR617412.1 CR624885.1 18 DOTS entries: DT.442715 DT.100025623 DT.95191672 DT.97799659 DT.97769862 DT.120684377 DT.101983753 DT.100020795 DT.70105331 DT.100852217 DT.120684383 DT.100684258 DT.100864300 DT.120684251 DT.120684342 DT.92044977 DT.95191809 DT.95375209 24/220 AceView cDNA sequences (see all 220
):BC010690 BE464631 CR624885 CD172465 AW953057 AW026671 T32676 AW162934 AI351676 AI089282 BU735616 CR612469 AA149513 AI131505 AA931102 BQ439580 CR609180 AU280703 AW051295 AW005213 BE909801 CA412385 AW262622 BQ026358
highest scoring ESTs for JAM3:AA149644 AA306190 AA029134 AA043327 AA043328 AA082108 AA131882 AA131883 AA149513 AA404374 Unigene Cluster for JAM3: Junctional adhesion molecule 3 Hs.150718 [show with all ESTs]Unigene Representative Sequence: NM_032801
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for JAM3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for JAM3
1 Ensembl transcript including schematic representation: ENST00000299106
|
Expression for JAM3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| JAM3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for JAM3
1 / 2 / 3 12 probe-sets matching JAM3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.150718
Expression variation in blood from EXPOLDB for JAM3 UniProtKB/Swiss-Prot: JAM3_HUMAN, Q9BX67Tissue specificity: Widely expressed. Highest expression in placenta, brain and kidney |
Orthologs for JAM3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for JAM3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for JAM3
ENSEMBL Gene Tree for JAM3 | Paralogs for JAM3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for JAM3 gene
- F11R2 JAM22
|
SNPs/Variants for JAM3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for JAM3 (up to first 250kb)
|
Disorders & Mutations for JAM3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606871
Human Genome Epidemiology Navigator: JAM3 (1 document)
|
Medical News for JAM3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for JAM3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/37 PubMed articles for JAM3 gene (see all 37
):- Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. (PubMed id 11590146)1, 3, 4 Arrate M.P.... Cunningham S.A. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)3, 4 Muller W.A. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. (PubMed id 12208882)3, 4 Santoso S....Chavakis T. (2002)
- Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis. (PubMed id 11944976)3, 4 Phillips H.M.... Wilson D.I. (2002)
- Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. (PubMed id 11739175)3, 4 Aurrand-Lions M.A....Imhof B.A. (2001)
- The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. (PubMed id 12953056)1, 3 Ebnet K....Vestweber D. (2003)
|
Search for JAM3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing JAM3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing JAM3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JAM3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for JAM3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for JAM3:

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Incremental update: 13 Oct 2009
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