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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JAM2 Gene

protein-coding   GIFtS: 60
GCID: GC21P027011

junctional adhesion molecule 2


(Previous symbol: C21orf43)
 Explore 1 disease affiliated with
JAM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for JAM2    

Aliases
for JAM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Junctional Adhesion Molecule 21 2 3     Vascular Endothelial Junction-Associated Molecule2 3
C21orf431 2 3     JAM-22 3
JAM-B1 2 3     JAM-IT/VE-JAM2
VE-JAM1 2 3     PRO2452
VEJAM2 3 5     Junctional Adhesion Molecule B2
CD3221 2     CD322 Antigen3
JAMB1 2     

External Ids:    HGNC: 146861   Entrez Gene: 584942   Ensembl: ENSG000001547217   OMIM: 6068705   UniProtKB: P570873   

Export aliases for JAM2 gene to outside databases

Previous GC identifers: GC21P023590 GC21P023673 GC21P025933 GC21P012414


Summaries
for JAM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for JAM2:
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein
encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and
endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a
role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for
this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

Gene Wiki entry for JAM2


Genomic Views
for JAM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for JAM2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for JAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.2

JAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAM2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P027011:  view genomic region     (about GC identifiers)

Start:
 27,011,584 bp from pter      End:
 27,089,874 bp from pter
Size:
 78,291 bases      Orientation:
 plus strand

Proteins
for JAM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087 (See protein sequence)
Recommended Name: Junctional adhesion molecule B precursor  
Size: 298 amino acids; 33207 Da
Subunit: Interacts with JAM3
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane protein
(By similarity). Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity)
Secondary accessions: B2R6T9 B4DGT9 Q6UXG6 Q6YNC1
Alternative splicing: 2 isoforms:  P57087-1   P57087-2   

Explore the universe of human proteins at neXtProt for JAM2: NX_P57087

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P57087

    • JAM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257337.1  NP_067042.1  NP_001257336.1  

    ENSEMBL proteins: 
     ENSP00000420419   ENSP00000383377   ENSP00000383376   ENSP00000383381   ENSP00000435555  
     ENSP00000436801   ENSP00000318416   ENSP00000392611  
    Reactome Protein details: P57087
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for JAM2 (JAM-B/VE-JAM)
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: JAM2
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    Novus Biologicals JAM2 Proteins
    Novus Biologicals JAM2 Lysates
    Sino Biological Recombinant Protein for JAM2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for JAM2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS10779521
    GO:0005923tight junction IEA--


    JAM2 for ontologies           About GeneDecksing



    JAM2 Antibody Products: 
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    Uscn ELISAs and CLIAs for JAM2

    Protein Domains /
    Families
    for JAM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    JAM2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P57087

    ProtoNet protein and cluster: P57087

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for JAM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: JAM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JAM2 (see all 7)
    OriGene shRNA RFP: JAM2
    OriGene siRNA: JAM2
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for JAM2

    Clone
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    GenScript: all cDNA clones in your preferred vector: JAM2 (NM_021219)
    Sino Biological Human cDNA Clone for JAM2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for JAM2
    Search LifeMap BioReagents cell lines for JAM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046982protein heterodimerization activity IEA--


    JAM2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for JAM2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin 

    Animal Models:
         Mouse knock-outs for JAM2: Jam2tm1Okud Jam2tm1.2Rha
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Jam2):
     hematopoietic system  homeostasis/metabolism  mortality/aging  normal  skeleton 

    JAM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for JAM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    2Cell adhesion Endothelial cell contacts by junctional mechanisms
    		Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    		Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    3Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    4amb2 Integrin signaling
    		amb2 Integrin signaling1.00
    5Leukocyte transendothelial migration
    		Leukocyte transendothelial migration1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for JAM2
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JAM2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for JAM2
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    1 BioSystems Pathway for JAM2 
        amb2 Integrin signaling

    4        Reactome Pathways for JAM2
        Hemostasis
    Integrin cell surface interactions
    Signal Transduction
    Cell surface interactions at the vascular wall


    4         Kegg Pathways  (Kegg details for JAM2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection


    JAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for JAM2 (P570871, 2, 3 ENSP000004204194) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085389 I2D: score=2 STRING: ENSP00000363921
    TJP1Q071573, ENSP000002815374I2D: score=2 STRING: ENSP00000281537
    F2RL2O002543, ENSP000002966414I2D: score=1 STRING: ENSP00000296641
    JAM3Q9BX671, ENSP000002991064EBI-3918416,EBI-4314733 STRING: ENSP00000299106
    ITGA4ENSP000003802274STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0016337cell-cell adhesion NAS10779521
    GO:0050900leukocyte migration TAS--


    JAM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for JAM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JAM2
    Search CenterWatch for drugs/clinical trials and news about JAM2 

    Transcripts
    for JAM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for JAM2 gene (3 alternative transcripts): 
    NM_001270408.1  NM_021219.3  NM_001270407.1  

    Unigene Cluster for JAM2:

    Junctional adhesion molecule 2
    Hs.517227  [show with all ESTs]
    Unigene Representative Sequence: NM_021219
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480456(uc002ylp.1 uc002ylq.1 uc011acf.1) ENST00000400533
    ENST00000400532(uc011ace.1) ENST00000400537 ENST00000400535 ENST00000460679
    ENST00000492962 ENST00000477351 ENST00000471689 ENST00000312957 ENST00000425221


    miRNA
    Products:             		 OriGene 3'-UTR Clone: JAM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JAM2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate JAM2
    SwitchGear 3'UTR luciferase reporter plasmid: JAM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for JAM2 (see all 7)
    OriGene shRNA RFP: JAM2
    OriGene siRNA: JAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAM2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: JAM2 (NM_021219)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAM2

    Additional cDNA sequence: 

    AF255910.1 AK056079.1 AK294769.1 AK312708.1 AY016009.1 AY077698.1 AY358361.1 BC017779.1 
    NR_072999.1 

    10 DOTS entries:

    DT.100801616  DT.411907  DT.416224  DT.411908  DT.121138107  DT.100784546  DT.100835567  DT.121138111 
    DT.99982500  DT.86845463 

    24/137 AceView cDNA sequences (see all 137):

    BU736621 AA865038 NM_021219 CB133611 AA405134 CD172203 AA405018 F04244 
    AX772824 CR621411 AY077698 BE218057 BG150380 AY016009 BF056970 AI652914 
    CR610497 BU730372 CR599894 BC017779 BM921497 AI201753 BM955588 CB138920 

    GeneLoc Exon Structure


    Expression
    for JAM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCTGCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    JAM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusMature Choroid Plexus CellsChoroid Plexus
    BoneZeugopod PeriosteumBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See JAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JAM2

    SOURCE GeneReport for Unigene cluster: Hs.517227

    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on
    high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries
    of high endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including JAM2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2

    Orthologs
    for JAM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for JAM2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves JAM21 junctional adhesion molecule 2 66.67(n)
    61.7(a)    		   418476  NM_001006257.1  NP_001006257.1 
    lizard
    (Anolis carolinensis)    		 Reptilia JAM26
    		 --
    		 55(a)
    		 1 ↔ 1
    		 3(148283881-148295796)
    zebrafish
    (Danio rerio)    		 Actinopterygii jam2a6
    jam2b6
    		 junctional adhesion molecule 2b
    		 33(a)
    32(a)
    		 1 ↔ many
    1 ↔ many
    		 1(469281-482944)
    9(35967549-35981700)


    ENSEMBL Gene Tree for JAM2 (if available)
    TreeFam Gene Tree for JAM2 (if available) 

    Paralogs
    for JAM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JAM2 gene
    CLMP2  ESAM2  VSIG82  GPA332  VSIG12  CXADR2  VSIG22  C1orf2042  
    IGSF112  JAM32  F11R2  
    2 SIMAP similar genes for JAM2 using alignment to 3 protein entries:     JAM2_HUMAN (see all proteins):
    JAM3    F11R

    JAM2 for paralogs           About GeneDecksing



    Genomic Variants
    for JAM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1302 NCBI SNPs in JAM2 are shown (see all 1302)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs7633321,2
    		C,F,O,H,--27009778(+) CCACAG/ATTCTA 4 -- us2k1108Minor allele frequency- A:0.29NS NA EA PA EU CA WA CSA 6866
    rs665055231,2
    		C,--27009802(+) TTCTT-/ATCTC 
                ATTGC     		4 -- us2k10--------
    rs671831601,2
    		C--27009804(+) CTTAT-/CTCAT 
                TGCTT     		4 -- us2k11Minor allele frequency- CTCAT:0.00NA 2
    rs786887861,2
    		--27009806(+) TATCTC/TATTGC 4 -- us2k10--------
    rs761559861,2
    		F,--27009923(+) TATCCC/TGATCC 4 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs792573321,2
    		F,--27009967(+) TTCTAA/CATAAA 4 -- us2k13Minor allele frequency- C:0.05WA NA EA 358
    rs1918414281,2
    		--27009971(+) AAATAA/TACCAT 4 -- us2k10--------
    rs134335181,2
    		C,F,--27009977(+) ACCATA/GATTTT 4 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1407601041,2
    		--27009986(+) TTTCAA/GTCTCC 4 -- us2k10--------
    rs758378371,2
    		F,--27010012(+) CTGTTT/GCCTCT 4 -- us2k11Minor allele frequency- G:0.05WA 118

    HapMap Linkage Disequilibrium report for JAM2 (27011584 - 27089874 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for JAM2: --

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    Disorders / Diseases
    for JAM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    JAM2 for disorders           About GeneDecksing

    OMIM gene information: 606870    OMIM disorders: --

    1 disease for JAM2:    About MalaCards
    down syndrome


    Export disorders for JAM2 gene to outside databases

    Publications
    for JAM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JAM2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with JAM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PubMed id 10945976)1, 2, 3 Cunningham S.A.... Brock T.A. (2000)
    2. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PubMed id 10779521)1, 2, 3 Palmeri D.... Rosen S.D. (2000)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)1, 2 Muller W.A. (2003)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2 Gardiner K....Davisson M. (2002)
    10. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. (PubMed id 11590146)1, 2 Arrate M.P.... Cunningham S.A. (2001)

    External Searches for JAM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing JAM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58494 HGNC: 14686 AceView: JAM2 Ensembl:ENSG00000154721 euGenes: HUgn58494
    ECgene: JAM2 Kegg: 58494 H-InvDB: JAM2

    Other Databases showing JAM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing JAM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JAM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for JAM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for JAM2 gene:
    Search GeneIP for patents involving JAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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