Aliases for JAM2 Gene
External Ids for JAM2 Gene
Previous HGNC Symbols for JAM2 Gene
Previous GeneCards Identifiers for JAM2 Gene
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for JAM2 Gene
JAM2 (Junctional Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.
UniProtKB/Swiss-Prot for JAM2 Gene
May play a role in the processes of lymphocyte homing to secondary lymphoid organs.