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Aliases for JAM2 Gene

Aliases for JAM2 Gene

  • Junctional Adhesion Molecule 2 2 3 4 5
  • Vascular Endothelial Junction-Associated Molecule 3 4
  • C21orf43 3 4
  • VE-JAM 3 4
  • JAM-2 3 4
  • JAM-B 3 4
  • VEJAM 3 4
  • CD322 Antigen 4
  • PRO245 3
  • CD322 3
  • JAMB 3

External Ids for JAM2 Gene

Previous HGNC Symbols for JAM2 Gene

  • C21orf43

Previous GeneCards Identifiers for JAM2 Gene

  • GC21P023590
  • GC21P023673
  • GC21P025933
  • GC21P027011
  • GC21P012414

Summaries for JAM2 Gene

Entrez Gene Summary for JAM2 Gene

  • This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JAM2 Gene

JAM2 (Junctional Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are ECM-receptor interaction and Tight junction. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot for JAM2 Gene

  • May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Gene Wiki entry for JAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAM2 Gene

Genomics for JAM2 Gene

Regulatory Elements for JAM2 Gene

Enhancers for JAM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JAM2 on UCSC Golden Path with GeneCards custom track

Promoters for JAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for JAM2 Gene

25,639,272 bp from pter
25,717,562 bp from pter
78,291 bases
Plus strand

Genomic View for JAM2 Gene

Genes around JAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAM2 Gene

Proteins for JAM2 Gene

  • Protein details for JAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Junctional adhesion molecule B
    Protein Accession:
    Secondary Accessions:
    • B2R6T9
    • B4DGT9
    • Q6UXG6
    • Q6YNC1

    Protein attributes for JAM2 Gene

    298 amino acids
    Molecular mass:
    33207 Da
    Quaternary structure:
    • Interacts with JAM3.

    Alternative splice isoforms for JAM2 Gene


neXtProt entry for JAM2 Gene

Proteomics data for JAM2 Gene at MOPED

Post-translational modifications for JAM2 Gene

  • Glycosylation at Asn 98, Asn 187, and Asn 236
  • Modification sites at PhosphoSitePlus

Other Protein References for JAM2 Gene

Antibody Products

No data available for DME Specific Peptides for JAM2 Gene

Domains & Families for JAM2 Gene

Protein Domains for JAM2 Gene

Suggested Antigen Peptide Sequences for JAM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAM2: view

Function for JAM2 Gene

Molecular function for JAM2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the processes of lymphocyte homing to secondary lymphoid organs.
genes like me logo Genes that share phenotypes with JAM2: view

Animal Models for JAM2 Gene

MGI Knock Outs for JAM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for JAM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAM2 Gene

Localization for JAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAM2 Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for JAM2 Gene COMPARTMENTS Subcellular localization image for JAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with JAM2: view

Pathways & Interactions for JAM2 Gene

genes like me logo Genes that share pathways with JAM2: view

Gene Ontology (GO) - Biological Process for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion NAS 10779521
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with JAM2: view

No data available for SIGNOR curated interactions for JAM2 Gene

Drugs & Compounds for JAM2 Gene

No Compound Related Data Available

Transcripts for JAM2 Gene

Unigene Clusters for JAM2 Gene

Junctional adhesion molecule 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JAM2 Gene

No ASD Table

Relevant External Links for JAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JAM2 Gene

mRNA expression in normal human tissues for JAM2 Gene

Protein differential expression in normal tissues from HIPED for JAM2 Gene

This gene is overexpressed in Placenta (15.2), Testis (9.5), Spinal cord (9.2), Frontal cortex (7.3), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JAM2 Gene

SOURCE GeneReport for Unigene cluster for JAM2 Gene Hs.517227

mRNA Expression by UniProt/SwissProt for JAM2 Gene

Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
genes like me logo Genes that share expression patterns with JAM2: view

Protein tissue co-expression partners for JAM2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for JAM2 Gene

Orthologs for JAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia JAM2 35
  • 90.63 (n)
  • 90.75 (a)
JAM2 36
  • 88 (a)
(Canis familiaris)
Mammalia JAM2 35
  • 90.75 (n)
  • 92.88 (a)
JAM2 36
  • 89 (a)
(Mus musculus)
Mammalia Jam2 35
  • 83.45 (n)
  • 81.07 (a)
Jam2 16
Jam2 36
  • 76 (a)
(Pan troglodytes)
Mammalia JAM2 35
  • 99.89 (n)
  • 100 (a)
JAM2 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Jam2 35
  • 83.93 (n)
  • 82.14 (a)
(Monodelphis domestica)
Mammalia JAM2 36
  • 71 (a)
(Gallus gallus)
Aves JAM2 35
  • 66.37 (n)
  • 61.54 (a)
JAM2 36
  • 52 (a)
(Anolis carolinensis)
Reptilia JAM2 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia jam2 35
  • 61.51 (n)
  • 55.4 (a)
(Danio rerio)
Actinopterygii jam2a 36
  • 31 (a)
jam2b 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for JAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAM2 Gene

Gene Tree for JAM2 (if available)
Gene Tree for JAM2 (if available)

Paralogs for JAM2 Gene

Paralogs for JAM2 Gene

(2) SIMAP similar genes for JAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JAM2: view

Variants for JAM2 Gene

Sequence variations from dbSNP and Humsavar for JAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs9976382 - 25,712,374(+) CAATG(A/C)GTGAA nc-transcript-variant, reference, missense
rs2276220 -- 25,705,958(+) TATGC(A/G)TAATT intron-variant
rs1475844 -- 25,705,429(-) AAGAA(C/T)CCATC intron-variant
rs4816260 -- 25,641,046(+) TCAGG(C/G)AAGGG intron-variant
rs4816261 -- 25,702,693(+) TCAAC(A/G)TAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAM2 Gene

Variant ID Type Subtype PubMed ID
esv2664665 CNV Deletion 23128226
nsv913653 CNV Loss 21882294

Variation tolerance for JAM2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for JAM2 Gene

Disorders for JAM2 Gene

Relevant External Links for JAM2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAM2 Gene

Publications for JAM2 Gene

  1. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PMID: 10945976) Cunningham S.A. … Brock T.A. (J. Biol. Chem. 2000) 2 3 4 67
  2. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PMID: 10779521) Palmeri D. … Rosen S.D. (J. Biol. Chem. 2000) 2 3
  3. Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts. (PMID: 25649652) Khondoker M. … . (J. Alzheimers Dis. 2015) 3
  4. Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. (PMID: 24357068) Arcangeli M.L. … Aurrand-Lions M. (Stem Cells 2014) 3
  5. Junctional adhesion molecules 2 and 3 may potentially be involved in progression of gastric adenocarcinoma tumors. (PMID: 23277282) Hajjari M. … Zeinoddini M. (Med. Oncol. 2013) 3

Products for JAM2 Gene

Sources for JAM2 Gene