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Aliases for JAM2 Gene

Aliases for JAM2 Gene

  • Junctional Adhesion Molecule 2 2 3 4
  • VEJAM 3 4 6
  • Vascular Endothelial Junction-Associated Molecule 3 4
  • C21orf43 3 4
  • VE-JAM 3 4
  • JAM-2 3 4
  • JAM-B 3 4
  • Junctional Adhesion Molecule B 3
  • JAM-IT/VE-JAM 3
  • CD322 Antigen 4
  • PRO245 3
  • CD322 3
  • JAMB 3

External Ids for JAM2 Gene

Previous HGNC Symbols for JAM2 Gene

  • C21orf43

Previous GeneCards Identifiers for JAM2 Gene

  • GC21P023590
  • GC21P023673
  • GC21P025933
  • GC21P027011
  • GC21P012414

Summaries for JAM2 Gene

Entrez Gene Summary for JAM2 Gene

  • This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JAM2 Gene

JAM2 (Junctional Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and Hemostasis. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot for JAM2 Gene

  • May play a role in the processes of lymphocyte homing to secondary lymphoid organs

Gene Wiki entry for JAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAM2 Gene

Genomics for JAM2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for JAM2 Gene

Start:
25,639,272 bp from pter
End:
25,717,562 bp from pter
Size:
78,291 bases
Orientation:
Plus strand

Genomic View for JAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAM2 Gene

No data available for Regulatory Elements for JAM2 Gene

Proteins for JAM2 Gene

  • Protein details for JAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57087-JAM2_HUMAN
    Recommended name:
    Junctional adhesion molecule B
    Protein Accession:
    P57087
    Secondary Accessions:
    • B2R6T9
    • B4DGT9
    • Q6UXG6
    • Q6YNC1

    Protein attributes for JAM2 Gene

    Size:
    298 amino acids
    Molecular mass:
    33207 Da
    Quaternary structure:
    • Interacts with JAM3.

    Alternative splice isoforms for JAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAM2 Gene

Proteomics data for JAM2 Gene at MOPED

Post-translational modifications for JAM2 Gene

  • Glycosylation at Asn98, Asn187, and Asn236
  • Modification sites at PhosphoSitePlus

Other Protein References for JAM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for JAM2 Gene

Domains for JAM2 Gene

Gene Families for JAM2 Gene

HGNC:
  • CD :CD molecules
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for JAM2 Gene

Suggested Antigen Peptide Sequences for JAM2 Gene

Graphical View of Domain Structure for InterPro Entry

P57087

UniProtKB/Swiss-Prot:

JAM2_HUMAN :
  • P57087
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAM2: view

Function for JAM2 Gene

Molecular function for JAM2 Gene

UniProtKB/Swiss-Prot Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

Gene Ontology (GO) - Molecular Function for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with JAM2: view
genes like me logo Genes that share phenotypes with JAM2: view

Animal Models for JAM2 Gene

MGI Knock Outs for JAM2:

Animal Model Products

CRISPR Products

miRNA for JAM2 Gene

miRTarBase miRNAs that target JAM2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for JAM2 Gene

Localization for JAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAM2 Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JAM2 Gene COMPARTMENTS Subcellular localization image for JAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10779521
GO:0005923 bicellular tight junction IEA --
genes like me logo Genes that share ontologies with JAM2: view

Pathways for JAM2 Gene

genes like me logo Genes that share pathways with JAM2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IEA --
GO:0007596 blood coagulation TAS --
GO:0016337 single organismal cell-cell adhesion NAS 10779521
GO:0030198 extracellular matrix organization TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with JAM2: view

Transcripts for JAM2 Gene

Unigene Clusters for JAM2 Gene

Junctional adhesion molecule 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JAM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAM2 Gene

No ASD Table

Relevant External Links for JAM2 Gene

GeneLoc Exon Structure for
JAM2
ECgene alternative splicing isoforms for
JAM2

Expression for JAM2 Gene

mRNA expression in normal human tissues for JAM2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JAM2 Gene

SOURCE GeneReport for Unigene cluster for JAM2 Gene Hs.517227

mRNA Expression by UniProt/SwissProt for JAM2 Gene

P57087-JAM2_HUMAN
Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.
genes like me logo Genes that share expressions with JAM2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for JAM2 Gene

Orthologs for JAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAM2 35
  • 99.89 (n)
  • 100 (a)
JAM2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JAM2 35
  • 90.63 (n)
  • 90.75 (a)
JAM2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAM2 35
  • 90.75 (n)
  • 92.88 (a)
JAM2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jam2 35
  • 83.45 (n)
  • 81.07 (a)
Jam2 16
Jam2 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JAM2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jam2 35
  • 83.93 (n)
  • 82.14 (a)
chicken
(Gallus gallus)
Aves JAM2 35
  • 66.37 (n)
  • 61.54 (a)
JAM2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JAM2 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jam2 35
  • 61.51 (n)
  • 55.4 (a)
zebrafish
(Danio rerio)
Actinopterygii jam2a 36
  • 31 (a)
OneToMany
jam2b 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for JAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAM2 Gene

ENSEMBL:
Gene Tree for JAM2 (if available)
TreeFam:
Gene Tree for JAM2 (if available)

Paralogs for JAM2 Gene

Paralogs for JAM2 Gene

Selected SIMAP similar genes for JAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JAM2: view

Variants for JAM2 Gene

Sequence variations from dbSNP and Humsavar for JAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs14150 -- 25,716,942(-) AGAAG(C/T)TGATC utr-variant-3-prime, nc-transcript-variant
rs15698 -- 25,714,840(-) TATTT(G/T)TTTAA utr-variant-3-prime, downstream-variant-500B, nc-transcript-variant
rs743319 -- 25,644,427(-) TGGGG(C/T)GCCTC intron-variant
rs763332 -- 25,637,466(+) CCACA(A/G)TTCTA upstream-variant-2KB
rs963103 -- 25,656,645(+) CTGGA(C/T)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAM2 Gene

Variant ID Type Subtype PubMed ID
esv2664665 CNV Deletion 23128226
nsv913653 CNV Loss 21882294

Relevant External Links for JAM2 Gene

HapMap Linkage Disequilibrium report
JAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAM2 Gene

Disorders for JAM2 Gene

Relevant External Links for JAM2

Genetic Association Database (GAD)
JAM2
genes like me logo Genes that share disorders with JAM2: view

No data available for UniProtKB/Swiss-Prot for JAM2 Gene

Publications for JAM2 Gene

  1. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PMID: 10779521) Palmeri D. … Rosen S.D. (J. Biol. Chem. 2000) 2 3 4
  2. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PMID: 10945976) Cunningham S.A. … Brock T.A. (J. Biol. Chem. 2000) 2 3 4
  3. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. (PMID: 11590146) Arrate M.P. … Cunningham S.A. (J. Biol. Chem. 2001) 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PMID: 12036298) Gardiner K. … Davisson M. (Genomics 2002) 3 4

Products for JAM2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate JAM2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for JAM2
    • Block miRNA regulation of JAM2 using miScript Target Protectors

    Sources for JAM2 Gene

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