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JAM2 Gene

protein-coding   GIFtS: 63
GCID: GC21P027011

Junctional Adhesion Molecule 2


(Previous symbol: C21orf43)
  Search for JAM2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Junctional Adhesion Molecule 21 2 3     CD3222
C21orf431 2 3     JAM-IT/VE-JAM2
VEJAM2 3 5     JAMB2
Vascular Endothelial Junction-Associated Molecule2 3     PRO2452
JAM-22 3     Junctional Adhesion Molecule B2
JAM-B2 3     CD322 Antigen3
VE-JAM2 3     

External Ids:    HGNC: 146861   Entrez Gene: 584942   Ensembl: ENSG000001547217   OMIM: 6068705   UniProtKB: P570873   

Export aliases for JAM2 gene to outside databases

Previous GC identifers: GC21P023590 GC21P023673 GC21P025933 GC21P012414


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for JAM2 Gene:
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The
protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both
epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell
types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for JAM2 Gene:
JAM2 (junctional adhesion molecule 2) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

Gene Wiki entry for JAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for JAM2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJAM2 promoter sequence
   Search Chromatin IP Primers for JAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.2

JAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAM2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P027011:  view genomic region     (about GC identifiers)

Start:
27,011,584 bp from pter      End:
27,089,874 bp from pter
Size:
78,291 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087 (See protein sequence)
Recommended Name: Junctional adhesion molecule B precursor  
Size: 298 amino acids; 33207 Da
Subunit: Interacts with JAM3
Secondary accessions: B2R6T9 B4DGT9 Q6UXG6 Q6YNC1
Alternative splicing: 3 isoforms:  P57087-1   P57087-2   P57087-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JAM2: NX_P57087

Explore proteomics data for JAM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98, Asn187, Asn236
  • Modification sites at PhosphoSitePlus

  • See JAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257337.1  NP_067042.1  NP_001257336.1  

    ENSEMBL proteins: 
     ENSP00000383376   ENSP00000420419   ENSP00000436801   ENSP00000318416   ENSP00000392611  
    Reactome Protein details: P57087

    JAM2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for JAM2
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    Novus Biologicals JAM2 Proteins
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    Sino Biological Recombinant Protein for JAM2
    Sino Biological Cell Lysate for JAM2
    ProSpec Recombinant Protein for JAM2
    Cloud-Clone Corp. Proteins for JAM2

     
    Search eBioscience for Proteins for JAM2 

    JAM2 Antibody Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JAM2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P57087

    ProtoNet protein and cluster: P57087

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with JAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAM2_HUMAN, P57087
    Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with JAM2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for JAM2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Jam2):
     hematopoietic system  homeostasis/metabolism  mortality/aging  normal  skeleton 

    Find genes that share phenotypes with JAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for JAM2: Jam2tm1.2Rha Jam2tm1Okud

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAM2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JAM2

    miRNA
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    miRTarBase miRNAs that target JAM2:
    hsa-mir-26b-5p (MIRT029914)

    Block miRNA regulation of human, mouse, rat JAM2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate JAM2
    SwitchGear 3'UTR luciferase reporter plasmidJAM2 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat JAM2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: JAM2 (NM_021219)
    Sino Biological Human cDNA Clone for JAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    JAM2_HUMAN, P57087: Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane
    protein (By similarity). Note=Localized at tight junctions of both epithelial and endothelial cells (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    mitochondrion2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS10779521
    GO:0005923tight junction IEA--

    Find genes that share ontologies with JAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for JAM2 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    2Hemostasis
    Hemostasis0.43
    3Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    4Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    5Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33


    Find genes that share SuperPaths with JAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for JAM2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for JAM2
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    1 BioSystems Pathway for JAM2
        amb2 Integrin signaling


    2 Reactome Pathways for JAM2
        Integrin cell surface interactions
    Cell surface interactions at the vascular wall


    4 Kegg Pathways  (Kegg details for JAM2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JAM2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JAM2 (P570871, 2, 3 ENSP000004204194) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085389 I2D: score=2 STRING: ENSP00000363921
    TJP1Q071573, ENSP000002815374I2D: score=2 STRING: ENSP00000281537
    F2RL2O002543, ENSP000002966414I2D: score=1 STRING: ENSP00000296641
    JAM3Q9BX671, ENSP000002991064EBI-3918416,EBI-4314733 STRING: ENSP00000299106
    ITGA4ENSP000003802274STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0016337cell-cell adhesion NAS10779521
    GO:0030198extracellular matrix organization TAS--
    GO:0050900leukocyte migration TAS--

    Find genes that share ontologies with JAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for JAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for JAM2 gene (3 alternative transcripts): 
    NM_001270408.1  NM_021219.3  NM_001270407.1  

    Unigene Cluster for JAM2:

    Junctional adhesion molecule 2
    Hs.517227  [show with all ESTs]
    Unigene Representative Sequence: NM_021219
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400532(uc011ace.1) ENST00000480456(uc002ylp.1 uc002ylq.1 uc011acf.1)
    ENST00000460679 ENST00000492962 ENST00000477351 ENST00000471689 ENST00000312957
    ENST00000425221
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat JAM2
      QuantiFast Probe-based Assays in human, mouse, rat JAM2

    Additional mRNA sequence: 

    AF255910.1 AK056079.1 AK294769.1 AK312708.1 AY016009.1 AY077698.1 AY358361.1 BC017779.1 
    NR_072999.1 

    10 DOTS entries:

    DT.100801616  DT.411907  DT.416224  DT.121138107  DT.411908  DT.100784546  DT.100835567  DT.121138111 
    DT.99982500  DT.86845463 

    Selected AceView cDNA sequences (see all 137):

    AX772824 BM955588 AW593293 CR618843 CB133611 CR599894 BU730372 CR621411 
    CR612856 BE218057 NM_021219 BU736621 CB125035 BF056970 F04244 CR605305 
    BC017779 AY016009 CR621227 AY358361 CD172203 BM921497 AA533191 CB137806 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    JAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTGCAGT
    JAM2 Expression
    About this image


    JAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor
    JAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517227

    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently
    expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the
    intercellular boundaries of high endothelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JAM2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat JAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for JAM2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jam21 , 5 junction adhesion molecule 21, 5 83.45(n)1
    81.07(a)1
      16 (46.92 cM)5
    673741  NM_023844.51  NP_076333.31 
     847741235 
    chicken
    (Gallus gallus)
    Aves JAM21 junctional adhesion molecule 2 66.37(n)
    61.54(a)
      418476  NM_001006257.1  NP_001006257.1 
    lizard
    (Anolis carolinensis)
    Reptilia JAM26
    junctional adhesion molecule 2
    51(a)
    1 ↔ 1
    3(148283881-148295796)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia jam21 junctional adhesion molecule 2 61.51(n)
    55.4(a)
      779665  NM_001078750.1  NP_001072218.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jam2a6
    jam2b6
    junctional adhesion molecule 2b
    31(a)
    30(a)
    1 ↔ many
    1 ↔ many
    1(469281-482944) ENSDARG00000058996
    9(35967549-35981700) ENSDARG00000079071


    ENSEMBL Gene Tree for JAM2 (if available)
    TreeFam Gene Tree for JAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for JAM2 gene
    JAM32  F11R2  
    2 SIMAP similar genes for JAM2 using alignment to 3 protein entries:     JAM2_HUMAN (see all proteins):
    JAM3    F11R

    Find genes that share paralogs with JAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for JAM2 (see all 1605)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7633321,2
    C,F,O,H--27009778(+) CCACAG/ATTCTA 4 -- us2k1108Minor allele frequency- A:0.29NS NA EA PA EU CA WA CSA 6866
    rs671831601,2
    C--27009804(+) CTTAT-/CTCAT 
            
    TGCTT
    4 -- us2k11Minor allele frequency- CTCAT:0.00NA 2
    rs786887861,2
    C--27009806(+) TATCTC/TATTGC 4 -- us2k10--------
    rs761559861,2
    C,F--27009923(+) TATCCC/TGATCC 4 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs792573321,2
    C,F--27009967(+) TTCTAA/CATAAA 4 -- us2k13Minor allele frequency- C:0.05WA NA EA 358
    rs1918414281,2
    --27009971(+) AAATAA/TACCAT 4 -- us2k10--------
    rs134335181,2
    C,F--27009977(+) ACCATA/GATTTT 4 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1407601041,2
    --27009986(+) TTTCAA/GTCTCC 4 -- us2k10--------
    rs758378371,2
    F--27010012(+) CTGTTT/GCCTCT 4 -- us2k11Minor allele frequency- G:0.05WA 118
    rs96471121,2
    C,F,H--27010042(+) TATGTC/GCTTCC 4 -- us2k1 trp323Minor allele frequency- G:0.17NS EA NA WA CSA 2764

    HapMap Linkage Disequilibrium report for JAM2 (27011584 - 27089874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for JAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664665CNV Deletion23128226
    nsv913653CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing JAM2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606870    OMIM disorders: --


    Find genes that share disorders with JAM2           About GenesLikeMe

    Genetic Association Database (GAD): JAM2

    Export disorders for JAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for JAM2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with JAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PubMed id 10945976)1, 2, 3 Cunningham S.A.... Brock T.A. (J. Biol. Chem. 2000)
    2. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PubMed id 10779521)1, 2, 3 Palmeri D.... Rosen S.D. (J. Biol. Chem. 2000)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)1, 2 Muller W.A. (Trends Immunol. 2003)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2 Gardiner K.... Davisson M. (Genomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 58494 HGNC: 14686 AceView: JAM2 Ensembl:ENSG00000154721 euGenes: HUgn58494
    ECgene: JAM2 Kegg: 58494 H-InvDB: JAM2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for JAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for JAM2 gene:
    Search GeneIP for patents involving JAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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