 |
 | Services
| |
 |
Aliases & Descriptions for JAM2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| C21orf43 2, 3 | | CD322 1, 2 | | JAM-B 1, 2, 3 | | JAM-IT/VE-JAM 2 | | JAMB 1, 2 | | OTTHUMP00000096100 2 | | PRO245 2 | | VE-JAM 1, 2, 3 | | VEJAM 2, 3, 5 |
| | | Descriptions |
|---|
| CD322 antigen 3 | | Vascular endothelial junction-associated molecule 2, 3 | | junctional adhesion molecule 2 2, 3 | | junctional adhesion molecule B 2 |
|
| | Search outside databases for aliases for JAM2 genePrevious GC identifers: GC21P023590 GC21P023673 |
Summaries for JAM2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for JAM2: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. [provided by RefSeq] UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organsGene Wiki entry for JAM2 |
Genomic Location for JAM2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q21.2 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q21.2JAM2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P025933:
(about GC identifiers)
Start:
|
25,933,455 bp from pter |
End:
|
26,011,745 bp from pter |
Size:
|
78,291 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000021.7 NT_011512.10
| Proteins for JAM2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087 (See
protein sequence)Recommended Name: Junctional adhesion molecule B precursor Size: 298 amino acids; 33207 Da
Subunit: Interacts with JAM3
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane protein (By similarity). Note=Localized at tight junctions of both epithelial and endothelial cells (By similarity)
Secondary accessions: B2R6T9 Q6UXG6 Q6YNC1REFSEQ proteins: NP_067042.1
ENSEMBL proteins: ENSP00000383376 ENSP00000383377 ENSP00000383381 ENSP00000383379 ENSP00000318416
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for JAM2: Assays for JAM2: | Protein
Domains/ Families for JAM2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P57087
ProtoNet protein and cluster: P57087 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087Similarity: Belongs to the immunoglobulin superfamilySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for JAM2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021219
Applied Biosystems Silencer® siRNAs for JAM2
Sigma-Aldrich siRNA and siRNA Panels for JAM2  Sigma-Aldrich shRNA Panels and shRNA for JAM2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021219                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021219                                  untagged cDNA clone in CMV expression vector: NM_021219 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021219
UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Jam2):
| Pathways & Interactions for JAM2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for JAM2 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for JAM2 
5/31 Interacting proteins for JAM2 (ENSP000003184163 P570872) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for JAM2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for JAM2
|
Transcripts for JAM2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021219
Sigma-Aldrich siRNA and siRNA Panels for JAM2  Sigma-Aldrich shRNA Panels and shRNA for JAM2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021219 REFSEQ mRNAs for JAM2 gene: NM_021219.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021219               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021219                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021219                                  untagged cDNA clone in CMV expression vector: NM_021219  Additional cDNA sequence: AF255910.1 AK294769.1 AK312708.1 AY016009.1 AY077698.1 AY358361.1 BC017779.1 CR599894.1 CR605305.1 CR610497.1 CR612856.1 CR618843.1 CR621227.1 CR621411.1 10 DOTS entries: DT.411907 DT.100801616 DT.411908 DT.100784546 DT.100835567 DT.416224 DT.121138111 DT.99982500 DT.121138107 DT.86845463 24/137 AceView cDNA sequences (see all 137
):AY016009 CR599894 BM955588 AY358361 CB125035 CB138920 BM723158 CR621411 AA865038 CR610497 BU730372 AA405018 CD172203 AI652914 AY077698 AI421450 CR621227 CR618843 F04244 BM955591 AI201753 BM921497 NM_021219 AA405134
highest scoring ESTs for JAM2:AA725566 AA410345 AA865038 AA912674 AA987434 AI017553 AI052637 AI123727 AI140139 AI201753 Unigene Cluster for JAM2: Junctional adhesion molecule 2 Hs.517227 [show with all ESTs]Unigene Representative Sequence: NM_021219
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations: ENST00000400532
ENST00000400533
ENST00000400537
ENST00000400535
ENST00000312957
|
Expression for JAM2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| JAM2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for JAM2
1 / 2 / 3 7 probe-sets matching JAM2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCCTGCAGT
SOURCE GeneReport for Unigene cluster: Hs.517227 UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells |
Orthologs for JAM2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for JAM2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for JAM2
ENSEMBL Gene Tree for JAM2 | Paralogs for JAM2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for JAM2 gene
- JAM32 F11R2
|
SNPs/Variants for JAM2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for JAM2 (up to first 250kb)
|
Disorders & Mutations for JAM2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606870
|
Medical News for JAM2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for JAM2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for JAM2 gene (see all 23
):- A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. (PubMed id 10945976)2, 3, 4 Cunningham S.A....Brock T.A. (2000)
- Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PubMed id 10779521)2, 3, 4 Palmeri D.... Rosen S.D. (2000)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)3, 4 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)3, 4 Muller W.A. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)3, 4 Clark H.F....Gray A. (2003)
- Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)3, 4 Gardiner K....Davisson M. (2002)
- Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. (PubMed id 11590146)3, 4 Arrate M.P.... Cunningham S.A. (2001)
- Expression of junctional adhesion molecules on the human lymphatic endothelium. (PubMed id 17822725)3 Ueki T....Sawa Y. (2008)
|
Search for JAM2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing JAM2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing JAM2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JAM2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for JAM2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for JAM2:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for JAM2 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|