Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JAM2 Gene

protein-coding   GIFtS: 62
GCID: GC21P027011

Junctional Adhesion Molecule 2


(Previous symbol: C21orf43)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Junctional Adhesion Molecule 21 2 3     CD3222
C21orf431 2 3     JAM-IT/VE-JAM2
VEJAM2 3 5     JAMB2
Vascular Endothelial Junction-Associated Molecule2 3     PRO2452
JAM-22 3     Junctional Adhesion Molecule B2
JAM-B2 3     CD322 Antigen3
VE-JAM2 3     

External Ids:    HGNC: 146861   Entrez Gene: 584942   Ensembl: ENSG000001547217   OMIM: 6068705   UniProtKB: P570873   

Export aliases for JAM2 gene to outside databases

Previous GC identifers: GC21P023590 GC21P023673 GC21P025933 GC21P012414


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for JAM2 Gene:
This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The
protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both
epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell
types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for JAM2 Gene: 
JAM2 (junctional adhesion molecule 2) is a protein-coding gene. Diseases associated with JAM2 include endotheliitis, and down syndrome, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell adhesion Endothelial cell contacts by junctional mechanisms. GO annotations related to this gene include protein binding and protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

Gene Wiki entry for JAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for JAM2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for JAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.2   Ensembl cytogenetic band:  21q21.3   HGNC cytogenetic band: 21q21.2

JAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAM2 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P027011:  view genomic region     (about GC identifiers)

Start:
27,011,584 bp from pter      End:
27,089,874 bp from pter
Size:
78,291 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087 (See protein sequence)
Recommended Name: Junctional adhesion molecule B precursor  
Size: 298 amino acids; 33207 Da
Subunit: Interacts with JAM3
Subcellular location: Cell junction, tight junction (By similarity). Cell membrane; Single-pass type I membrane
protein (By similarity). Note=Localized at tight junctions of both epithelial and endothelial cells (By
similarity)
Secondary accessions: B2R6T9 B4DGT9 Q6UXG6 Q6YNC1
Alternative splicing: 3 isoforms:  P57087-1   P57087-2   P57087-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JAM2: NX_P57087

Explore proteomics data for JAM2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57087

  • JAM2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    JAM2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001257337.1  NP_067042.1  NP_001257336.1  

    ENSEMBL proteins: 
     ENSP00000383376   ENSP00000420419   ENSP00000436801   ENSP00000318416   ENSP00000392611  
    Reactome Protein details: P57087
    Human Recombinant Protein Products for JAM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for JAM2 (JAM-B/VE-JAM)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for JAM2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for JAM2
    GenScript Custom Purified and Recombinant Proteins Services for JAM2
    Novus Biologicals JAM2 Proteins
    Novus Biologicals JAM2 Lysates
    Sino Biological Recombinant Protein for JAM2
    Sino Biological Cell Lysate for JAM2 
    ProSpec Recombinant Protein for JAM2
    Cloud-Clone Corp. Proteins for JAM2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS10779521
    GO:0005923tight junction IEA--

    JAM2 for ontologies           About GeneDecksing



    JAM2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for JAM2 (JAM-B/VE-JAM)
    OriGene Antibodies for JAM2
    OriGene Custom Antibody Services for JAM2
    GenScript Custom Superior Antibodies Services for JAM2
    Novus Biologicals JAM2 Antibodies
    Abcam antibodies for JAM2
    Cloud-Clone Corp. Antibodies for JAM2 
    ThermoFisher Antibodies for JAM2
    LSBio Antibodies in human, mouse, rat for JAM2 

    Assay Products for JAM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for JAM2
    R&D Systems Proteome Profiler Antibody Arrays for JAM2 (JAM-B/VE-JAM)
    GenScript Custom Assay Services for JAM2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JAM2 
    Cloud-Clone Corp. CLIAs for JAM2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P57087

    ProtoNet protein and cluster: P57087

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Similarity: Belongs to the immunoglobulin superfamily
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    JAM2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAM2_HUMAN, P57087
    Function: May play a role in the processes of lymphocyte homing to secondary lymphoid organs

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0046982protein heterodimerization activity IEA--
         
    JAM2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for JAM2:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica  
     Decreased Salmonella-containin 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Jam2):
     hematopoietic system  homeostasis/metabolism  mortality/aging  normal  skeleton 

    JAM2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for JAM2: Jam2tm1Okud Jam2tm1.2Rha

       inGenious Targeting Laboratory - Custom generated mouse model solutions for JAM2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JAM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JAM2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JAM2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JAM2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate JAM2
    SwitchGear 3'UTR luciferase reporter plasmidJAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for JAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAM2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JAM2
    Sirion Biotech Customized adenovirus for overexpression of JAM2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for JAM2 (see all 7)
    OriGene ORF clones in mouse, rat for JAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JAM2 (NM_021219)
    Sino Biological Human cDNA Clone for JAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2
    Sirion Biotech Customized lentivirus for stable overexpression of JAM2 
                         Customized lentivirus expression plasmids for stable overexpression of JAM2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JAM2
    Search LifeMap BioReagents cell lines for JAM2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for JAM2 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    2Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms0.97
    3Signaling by GPCR
    Signal Transduction0.55
    4Platelet activation, signaling and aggregation
    Hemostasis0.43
    5Integrin Pathway
    Transendothelial Migration of Leukocytes0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for JAM2
        Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for JAM2
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions
    Transendothelial Migration of Leukocytes

    2 GeneGo (Thomson Reuters) Pathways for JAM2
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions

    1 BioSystems Pathway for JAM2
        amb2 Integrin signaling


    4        Reactome Pathways for JAM2
        Hemostasis
    Integrin cell surface interactions
    Signal Transduction
    Cell surface interactions at the vascular wall


    4         Kegg Pathways  (Kegg details for JAM2):
        Cell adhesion molecules (CAMs)
    Tight junction
    Leukocyte transendothelial migration
    Epithelial cell signaling in Helicobacter pylori infection


    JAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for JAM2 (P570871, 2, 3 ENSP000004204194) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARD3Q8TEW02, 3, ENSP000003639214MINT-4085389 I2D: score=2 STRING: ENSP00000363921
    TJP1Q071573, ENSP000002815374I2D: score=2 STRING: ENSP00000281537
    F2RL2O002543, ENSP000002966414I2D: score=1 STRING: ENSP00000296641
    JAM3Q9BX671, ENSP000002991064EBI-3918416,EBI-4314733 STRING: ENSP00000299106
    ITGA4ENSP000003802274STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion IEA--
    GO:0007596blood coagulation TAS--
    GO:0016337cell-cell adhesion NAS10779521
    GO:0050900leukocyte migration TAS--

    JAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JAM2

    Search CenterWatch for drugs/clinical trials and news about JAM2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for JAM2 gene (3 alternative transcripts): 
    NM_001270408.1  NM_021219.3  NM_001270407.1  

    Unigene Cluster for JAM2:

    Junctional adhesion molecule 2
    Hs.517227  [show with all ESTs]
    Unigene Representative Sequence: NM_021219
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400532(uc011ace.1) ENST00000480456(uc002ylp.1 uc002ylq.1 uc011acf.1)
    ENST00000460679 ENST00000492962 ENST00000477351 ENST00000471689 ENST00000312957
    ENST00000425221
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JAM2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate JAM2
    SwitchGear 3'UTR luciferase reporter plasmidJAM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for JAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAM2
    Clone
    Products:
         
    OriGene clones in human, mouse for JAM2 (see all 7)
    OriGene ORF clones in mouse, rat for JAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JAM2 (NM_021219)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2
    Sirion Biotech Customized lentivirus for stable overexpression of JAM2 
                         Customized lentivirus expression plasmids for stable overexpression of JAM2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for JAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for JAM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JAM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAM2

    Additional mRNA sequence: 

    AF255910.1 AK056079.1 AK294769.1 AK312708.1 AY016009.1 AY077698.1 AY358361.1 BC017779.1 
    NR_072999.1 

    10 DOTS entries:

    DT.100801616  DT.411907  DT.416224  DT.121138107  DT.411908  DT.100784546  DT.100835567  DT.121138111 
    DT.99982500  DT.86845463 

    24/137 AceView cDNA sequences (see all 137):

    BG150380 CR599894 NM_021219 CR612856 CR605305 AA405018 BU730372 CB133611 
    BM921497 CD172203 AW593293 CB137806 CR621227 F04244 CR621411 BM955588 
    CB138920 AY358361 CR610497 BE218057 AI652914 AX772824 AY077698 AA865038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JAM2 expression in normal human tissues (normalized intensities)      JAM2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTGCAGT
    JAM2 Expression
    About this image


    JAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             mouse/organ system/cardiovascular system   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See JAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JAM2

    SOURCE GeneReport for Unigene cluster: Hs.517227

    UniProtKB/Swiss-Prot: JAM2_HUMAN, P57087
    Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently
    expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the
    intercellular boundaries of high endothelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including JAM2: 
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for JAM2
    OriGene qSTAR qPCR primer pairs in human, mouse for JAM2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JAM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for JAM2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jam21 , 5 junction adhesion molecule 21, 5 82.72(n)1
    79.8(a)1
      16 (46.92 cM)5
    673741  NM_023844.51  NP_076333.31 
     847741235 
    chicken
    (Gallus gallus)
    Aves JAM21 junctional adhesion molecule 2 66.67(n)
    61.7(a)
      418476  NM_001006257.1  NP_001006257.1 
    lizard
    (Anolis carolinensis)
    Reptilia JAM26
    Uncharacterized protein
    52(a)
    1 ↔ 1
    3(148283881-148295796)
    zebrafish
    (Danio rerio)
    Actinopterygii jam2a6
    jam2b6
    junctional adhesion molecule 2b
    32(a)
    30(a)
    1 ↔ many
    1 ↔ many
    1(469281-482944)
    9(35967549-35981700)


    ENSEMBL Gene Tree for JAM2 (if available)
    TreeFam Gene Tree for JAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JAM2 gene
    JAM32  F11R2  
    2 SIMAP similar genes for JAM2 using alignment to 3 protein entries:     JAM2_HUMAN (see all proteins):
    JAM3    F11R

    JAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1605 SNPs in JAM2 are shown (see all 1605)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7633321,2
    C,F,O,H--27009778(+) CCACAG/ATTCTA 4 -- us2k1108Minor allele frequency- A:0.29NS NA EA PA EU CA WA CSA 6866
    rs671831601,2
    C--27009804(+) CTTAT-/CTCAT 
            
    TGCTT
    4 -- us2k11Minor allele frequency- CTCAT:0.00NA 2
    rs786887861,2
    C--27009806(+) TATCTC/TATTGC 4 -- us2k10--------
    rs761559861,2
    C,F--27009923(+) TATCCC/TGATCC 4 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs792573321,2
    C,F--27009967(+) TTCTAA/CATAAA 4 -- us2k13Minor allele frequency- C:0.05WA NA EA 358
    rs1918414281,2
    --27009971(+) AAATAA/TACCAT 4 -- us2k10--------
    rs134335181,2
    C,F--27009977(+) ACCATA/GATTTT 4 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1407601041,2
    --27009986(+) TTTCAA/GTCTCC 4 -- us2k10--------
    rs758378371,2
    F--27010012(+) CTGTTT/GCCTCT 4 -- us2k11Minor allele frequency- G:0.05WA 118
    rs96471121,2
    C,F,H--27010042(+) TATGTC/GCTTCC 4 -- us2k1 trp323Minor allele frequency- G:0.17NS EA NA WA CSA 2764

    HapMap Linkage Disequilibrium report for JAM2 (27011584 - 27089874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for JAM2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664665CNV Deletion23128226
    nsv913653CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing JAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for JAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606870    OMIM disorders: --

    2 diseases for JAM2:    About MalaCards
    endotheliitis    down syndrome


    JAM2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): JAM2

    Export disorders for JAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JAM2 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with JAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PubMed id 10945976)1, 2, 3 Cunningham S.A.... Brock T.A. (2000)
    2. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PubMed id 10779521)1, 2, 3 Palmeri D.... Rosen S.D. (2000)
    3. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (2009)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (PubMed id 12810109)1, 2 Muller W.A. (2003)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. (PubMed id 12036298)1, 2 Gardiner K....Davisson M. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 58494 HGNC: 14686 AceView: JAM2 Ensembl:ENSG00000154721 euGenes: HUgn58494
    ECgene: JAM2 Kegg: 58494 H-InvDB: JAM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for JAM2 gene:
    Search GeneIP for patents involving JAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for JAM2 (JAM-B/VE-JAM)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for JAM2 (JAM-B/VE-JAM)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for JAM2 (JAM-B/VE-JAM)  
     OriGene Antibodies for JAM2   OriGene RNAi products in human, mouse, rat for JAM2  
     OriGene qPCR primer pairs and template standards for JAM2   OriGene Protein Over-expression Lysate for JAM2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for JAM2  
     OriGene qSTAR qPCR primer pairs in human, mouse for JAM2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for JAM2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for JAM2   OriGene Custom Protein Services for JAM2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JAM2
     QIAGEN SeqTarget long-range PCR primers for resequencing JAM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAM2
     GenScript Custom Purified and Recombinant Proteins Services for JAM2 GenScript cDNA clones with any tag delivered in your preferred vector for JAM2
     GenScript Custom Assay Services for JAM2 GenScript Custom Superior Antibodies Services for JAM2
     GenScript Custom overexpressing Cell Line Services for JAM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for JAM2
     Search Chromatin IP Primers for JAM2
     RT2 qPCR Primer Assay in human, mouse, rat JAM2
     GNC Network for JAM2
     SABiosciences PCR Arrays including human, mouse, rat JAM2
     Search Tocris compounds for JAM2
     Proteins and Antibodies for JAM2
     Cell Lysates for JAM2
     cDNA Clones for JAM2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     JAM2 antibodies
     JAM2 proteins
     JAM2 lysates
     Antibodies for JAM2
     See all of Abcam's Antibodies, Kits and Proteins for JAM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for JAM2




     Proteins for JAM2
     Antibodies for JAM2
     ELISAs for JAM2
     CLIAs for JAM2
     Search LifeMap BioReagents cell lines for JAM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAM2
     SwitchGear 3'UTR luciferase reporter plasmids for JAM2
     SwitchGear Promoter luciferase reporter plasmids for JAM2
     ThermoFisher Antibodies for JAM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAM2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for JAM2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JAM2
    Customized:
     lentivirus for stable overexpression of JAM2
     lentivirus expression plasmids for stable overexpression of JAM2
     adenovirus for overexpression of JAM2
     LSBio Antibodies in human, mouse, rat for JAM2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      JAM2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4