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Aliases for JAM2 Gene

Aliases for JAM2 Gene

  • Junctional Adhesion Molecule 2 2 3 4 5
  • Vascular Endothelial Junction-Associated Molecule 3 4
  • C21orf43 3 4
  • VE-JAM 3 4
  • JAM-2 3 4
  • JAM-B 3 4
  • VEJAM 3 4
  • Junctional Adhesion Molecule B 3
  • CD322 Antigen 4
  • PRO245 3
  • CD322 3
  • JAMB 3

External Ids for JAM2 Gene

Previous HGNC Symbols for JAM2 Gene

  • C21orf43

Previous GeneCards Identifiers for JAM2 Gene

  • GC21P023590
  • GC21P023673
  • GC21P025933
  • GC21P027011
  • GC21P012414

Summaries for JAM2 Gene

Entrez Gene Summary for JAM2 Gene

  • This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for JAM2 Gene

JAM2 (Junctional Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is JAM3.

UniProtKB/Swiss-Prot for JAM2 Gene

  • May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Gene Wiki entry for JAM2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAM2 Gene

Genomics for JAM2 Gene

Regulatory Elements for JAM2 Gene

Enhancers for JAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G025717 0.7 ENCODE 10.3 +78.4 78442 0.1 NFIB JUN CEBPG ZNF316 NFE2 MAFG DPF2 ATF2 OSR2 PRDM6 GABPA MRPL39 JAM2 GC21P025693
GH21G025818 0.6 FANTOM5 ENCODE 10.5 +179.2 179201 0.8 JUND JAM2 RNU6-926P MRPL39 LOC105372757 LOC105372756
GH21G025700 0.5 ENCODE 11.1 +61.6 61612 0.2 GATA3 RAD21 TCF7L2 FOXA1 JAM2 GABPA ATP5J GC21P025693
GH21G025638 0.9 ENCODE 6.1 +0.3 270 2.4 ZNF76 RAD21 GLIS2 EGR1 ZNF366 ZNF143 RELB CREM EGR2 SP3 MRPL39 ATP5J GABPA JAM2 RNGTTP1
GH21G025670 0.4 ENCODE 11.7 +31.5 31506 0.8 JUND MRPL39 JAM2 FDX1P2 RNGTTP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JAM2 on UCSC Golden Path with GeneCards custom track

Promoters for JAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140754 628 2200 ZNF76 FEZF1 RAD21 GLIS2 EGR1 ZNF366 RELB CREM EGR2 SP3

Genomic Location for JAM2 Gene

25,639,272 bp from pter
25,717,562 bp from pter
78,291 bases
Plus strand

Genomic View for JAM2 Gene

Genes around JAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAM2 Gene

Proteins for JAM2 Gene

  • Protein details for JAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Junctional adhesion molecule B
    Protein Accession:
    Secondary Accessions:
    • B2R6T9
    • B4DGT9
    • Q6UXG6
    • Q6YNC1

    Protein attributes for JAM2 Gene

    298 amino acids
    Molecular mass:
    33207 Da
    Quaternary structure:
    • Interacts with JAM3.

    Alternative splice isoforms for JAM2 Gene


neXtProt entry for JAM2 Gene

Post-translational modifications for JAM2 Gene

  • Glycosylation at isoforms=2, 398, posLast=187187, and posLast=236236
  • Modification sites at PhosphoSitePlus

Other Protein References for JAM2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for JAM2

Protein Products

Assay Products

  • Cloud-Clone Corp Assay Kits for JAM2

No data available for DME Specific Peptides for JAM2 Gene

Domains & Families for JAM2 Gene

Suggested Antigen Peptide Sequences for JAM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily.
  • Belongs to the immunoglobulin superfamily.
genes like me logo Genes that share domains with JAM2: view

Function for JAM2 Gene

Molecular function for JAM2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the processes of lymphocyte homing to secondary lymphoid organs.

Gene Ontology (GO) - Molecular Function for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with JAM2: view
genes like me logo Genes that share phenotypes with JAM2: view

Animal Models for JAM2 Gene

MGI Knock Outs for JAM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for JAM2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAM2 Gene

Localization for JAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAM2 Gene

Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAM2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10779521
GO:0005923 bicellular tight junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with JAM2: view

Pathways & Interactions for JAM2 Gene

genes like me logo Genes that share pathways with JAM2: view

Gene Ontology (GO) - Biological Process for JAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion IEA --
GO:0016337 single organismal cell-cell adhesion NAS 10779521
GO:0030198 extracellular matrix organization TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with JAM2: view

No data available for SIGNOR curated interactions for JAM2 Gene

Drugs & Compounds for JAM2 Gene

No Compound Related Data Available

Transcripts for JAM2 Gene

Unigene Clusters for JAM2 Gene

Junctional adhesion molecule 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAM2 Gene

No ASD Table

Relevant External Links for JAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JAM2 Gene

Protein differential expression in normal tissues from HIPED for JAM2 Gene

This gene is overexpressed in Placenta (15.2), Testis (9.5), Spinal cord (9.2), Frontal cortex (7.3), and Gallbladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JAM2 Gene

Protein tissue co-expression partners for JAM2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JAM2 Gene:


SOURCE GeneReport for Unigene cluster for JAM2 Gene:


mRNA Expression by UniProt/SwissProt for JAM2 Gene:

Tissue specificity: Highest expression in the heart, placenta, lung, foreskin and lymph node. Prominently expressed on high endothelial venules, also present on the endothelia of other vessels. Localized to the intercellular boundaries of high endothelial cells.

Evidence on tissue expression from TISSUES for JAM2 Gene

  • Nervous system(4.8)
  • Heart(4.5)
  • Lung(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with JAM2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for JAM2 Gene

Orthologs for JAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia JAM2 34 35
  • 99.89 (n)
(Canis familiaris)
Mammalia JAM2 34 35
  • 90.75 (n)
(Bos Taurus)
Mammalia JAM2 34 35
  • 90.63 (n)
(Rattus norvegicus)
Mammalia Jam2 34
  • 83.93 (n)
(Mus musculus)
Mammalia Jam2 34 16 35
  • 83.45 (n)
(Monodelphis domestica)
Mammalia JAM2 35
  • 71 (a)
(Gallus gallus)
Aves JAM2 35 34
  • 66.37 (n)
(Anolis carolinensis)
Reptilia JAM2 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia jam2 34
  • 61.51 (n)
(Danio rerio)
Actinopterygii jam2a 35
  • 31 (a)
jam2b 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 22 (a)
Species where no ortholog for JAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAM2 Gene

Gene Tree for JAM2 (if available)
Gene Tree for JAM2 (if available)

Paralogs for JAM2 Gene

Paralogs for JAM2 Gene

(2) SIMAP similar genes for JAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with JAM2: view

Variants for JAM2 Gene

Sequence variations from dbSNP and Humsavar for JAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000008823 -- 25,696,593(+) AGTCC(A/C)ACAAG intron-variant
rs1000048472 -- 25,658,161(+) AAATC(A/G)TTTAG intron-variant
rs1000057032 -- 25,677,516(+) AGAGA(A/T)AATGA intron-variant
rs1000059518 -- 25,696,360(+) CTCGG(C/T)ATCAG intron-variant
rs1000101846 -- 25,658,504(+) TGAAC(C/T)CTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAM2 Gene

Variant ID Type Subtype PubMed ID
esv2664665 CNV deletion 23128226
esv3646714 CNV loss 21293372
nsv1064561 CNV loss 25217958
nsv1114274 CNV deletion 24896259

Variation tolerance for JAM2 Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAM2 Gene

Disorders for JAM2 Gene

Relevant External Links for JAM2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for JAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAM2 Gene

Publications for JAM2 Gene

  1. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. (PMID: 10779521) Palmeri D. … Rosen S.D. (J. Biol. Chem. 2000) 2 3 4 64
  2. A novel protein with homology to the junctional adhesion molecule: Characterization of leukocyte interactions. (PMID: 10945976) Cunningham S.A. … Brock T.A. (J. Biol. Chem. 2000) 2 3 4 64
  3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 46 64
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for JAM2 Gene

Sources for JAM2 Gene

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