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Aliases for JAKMIP3 Gene

Aliases for JAKMIP3 Gene

  • Janus Kinase And Microtubule Interacting Protein 3 2 3
  • C10orf39 3 4 6
  • Jamip3 3 4 6
  • NECC2 3 4 6
  • Neuroendocrine Long Coiled-Coil Protein 2 3 4
  • Neuroendocrine Long Coiled-Coil 2 2 3
  • C10orf14 3 4
  • Janus Kinase And Microtubule-Interacting Protein 3 3
  • Chromosome 10 Open Reading Frame 39 2
  • Chromosome 10 Open Reading Frame 14 2
  • BA140A10.5 3

External Ids for JAKMIP3 Gene

Previous HGNC Symbols for JAKMIP3 Gene

  • C10orf39
  • C10orf14

Previous GeneCards Identifiers for JAKMIP3 Gene

  • GC10P133769
  • GC10P133918
  • GC10P127467

Summaries for JAKMIP3 Gene

GeneCards Summary for JAKMIP3 Gene

JAKMIP3 (Janus Kinase And Microtubule Interacting Protein 3) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and kinase binding. An important paralog of this gene is JAKMIP2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAKMIP3 Gene

Genomics for JAKMIP3 Gene

Regulatory Elements for JAKMIP3 Gene

Genomic Location for JAKMIP3 Gene

Start:
132,065,864 bp from pter
End:
132,184,978 bp from pter
Size:
119,115 bases
Orientation:
Plus strand

Genomic View for JAKMIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JAKMIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAKMIP3 Gene

Proteins for JAKMIP3 Gene

  • Protein details for JAKMIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZ66-JKIP3_HUMAN
    Recommended name:
    Janus kinase and microtubule-interacting protein 3
    Protein Accession:
    Q5VZ66
    Secondary Accessions:
    • A6PW00
    • Q69YM6
    • Q6ZT29

    Protein attributes for JAKMIP3 Gene

    Size:
    844 amino acids
    Molecular mass:
    98529 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86766.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH10388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH10388.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for JAKMIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAKMIP3 Gene

Proteomics data for JAKMIP3 Gene at MOPED

Post-translational modifications for JAKMIP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for JAKMIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for JAKMIP3 Gene

Domains for JAKMIP3 Gene

Protein Domains for JAKMIP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JAKMIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZ66

UniProtKB/Swiss-Prot:

JKIP3_HUMAN :
  • Q5VZ66
Family:
  • Belongs to the JAKMIP family.
genes like me logo Genes that share domains with JAKMIP3: view

No data available for Gene Families for JAKMIP3 Gene

Function for JAKMIP3 Gene

Gene Ontology (GO) - Molecular Function for JAKMIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with JAKMIP3: view

Animal Model Products

CRISPR Products

miRNA for JAKMIP3 Gene

miRTarBase miRNAs that target JAKMIP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JAKMIP3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for JAKMIP3 Gene

Localization for JAKMIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAKMIP3 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JAKMIP3 Gene COMPARTMENTS Subcellular localization image for JAKMIP3 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for JAKMIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with JAKMIP3: view

Pathways for JAKMIP3 Gene

SuperPathways for JAKMIP3 Gene

No Data Available

Interacting Proteins for JAKMIP3 Gene

Gene Ontology (GO) - Biological Process for JAKMIP3 Gene

None

No data available for Pathways by source for JAKMIP3 Gene

Transcripts for JAKMIP3 Gene

mRNA/cDNA for JAKMIP3 Gene

Unigene Clusters for JAKMIP3 Gene

Janus kinase and microtubule interacting protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for JAKMIP3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP3 Gene

No ASD Table

Relevant External Links for JAKMIP3 Gene

GeneLoc Exon Structure for
JAKMIP3
ECgene alternative splicing isoforms for
JAKMIP3

Expression for JAKMIP3 Gene

mRNA expression in normal human tissues for JAKMIP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JAKMIP3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.3).

Protein differential expression in normal tissues for JAKMIP3 Gene

This gene is overexpressed in Liver (51.2) and Urine (10.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for JAKMIP3 Gene

SOURCE GeneReport for Unigene cluster for JAKMIP3 Gene Hs.106254

mRNA Expression by UniProt/SwissProt for JAKMIP3 Gene

Q5VZ66-JKIP3_HUMAN
Tissue specificity: Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues including heart, testis and prostate.
genes like me logo Genes that share expressions with JAKMIP3: view

Expression partners for JAKMIP3 Gene

In Situ Assay Products

Orthologs for JAKMIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAKMIP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia JAKMIP3 35
  • 88.98 (n)
  • 93.85 (a)
JAKMIP3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAKMIP3 35
  • 87.61 (n)
  • 91.13 (a)
JAKMIP3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jakmip3 35
  • 87.32 (n)
  • 94.41 (a)
Jakmip3 16
Jakmip3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia JAKMIP3 35
  • 97.44 (n)
  • 96.82 (a)
JAKMIP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jakmip3 35
  • 87.4 (n)
  • 94.41 (a)
oppossum
(Monodelphis domestica)
Mammalia JAKMIP3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves JAKMIP3 35
  • 81.97 (n)
  • 89.62 (a)
JAKMIP3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JAKMIP3 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jakmip3 35
  • 76.41 (n)
  • 84.12 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334213 35
  • 72.92 (n)
  • 78.24 (a)
JAKMIP3 36
  • 78 (a)
OneToOne
Species with no ortholog for JAKMIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAKMIP3 Gene

ENSEMBL:
Gene Tree for JAKMIP3 (if available)
TreeFam:
Gene Tree for JAKMIP3 (if available)

Paralogs for JAKMIP3 Gene

Paralogs for JAKMIP3 Gene

Selected SIMAP similar genes for JAKMIP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JAKMIP3: view

Variants for JAKMIP3 Gene

Sequence variations from dbSNP and Humsavar for JAKMIP3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs867254 -- 132,123,673(+) TGGGC(A/G)TGAGT intron-variant
rs869250 -- 132,156,267(+) TCCTC(A/G)TACCC intron-variant
rs869251 -- 132,156,355(+) TAGAA(C/T)AGTGC intron-variant
rs869252 -- 132,156,368(+) TCCCA(C/T)GAGCA intron-variant
rs869253 -- 132,156,394(+) CTGCC(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAKMIP3 Gene

Variant ID Type Subtype PubMed ID
nsv896120 CNV Loss 21882294
nsv896121 CNV Loss 21882294
nsv896122 CNV Loss 21882294
dgv838n71 CNV Loss 21882294
nsv896125 CNV Loss 21882294
nsv832030 CNV Loss 17160897
nsv896126 CNV Loss 21882294
dgv839n71 CNV Loss 21882294
dgv840n71 CNV Loss 21882294
esv2743610 CNV Deletion 23290073
esv996010 CNV Deletion 20482838
esv1281400 CNV Deletion 17803354
esv2743611 CNV Deletion 23290073
esv2743612 CNV Deletion 23290073
esv2743613 CNV Deletion 23290073
esv2743614 CNV Deletion 23290073
esv2743615 CNV Deletion 23290073
esv2669676 CNV Deletion 23128226
esv2675722 CNV Deletion 23128226
dgv841n71 CNV Loss 21882294
esv2743616 CNV Deletion 23290073
dgv842n71 CNV Loss 21882294
esv2301386 CNV Deletion 18987734
esv2743617 CNV Deletion 23290073
nsv523296 CNV Loss 19592680
nsv825652 CNV Gain 20364138
nsv896140 CNV Loss 21882294
esv2743618 CNV Deletion 23290073
esv2643236 CNV Insertion 19546169
esv1418735 CNV Insertion 17803354
esv2674885 CNV Deletion 23128226
esv21792 CNV Gain+Loss 19812545
esv2743620 CNV Deletion 23290073
esv2743621 CNV Deletion 23290073
esv2743622 CNV Deletion 23290073
nsv825654 CNV Gain 20364138
nsv896141 CNV Loss 21882294
esv2656970 CNV Deletion 23128226
esv2851 CNV Deletion 18987735
esv2743623 CNV Deletion 23290073
esv2743624 CNV Deletion 23290073
esv2743625 CNV Deletion 23290073
esv2743626 CNV Deletion 23290073
esv2743627 CNV Deletion 23290073
esv1290967 CNV Insertion 17803354
dgv843n71 CNV Loss 21882294
nsv825655 CNV Gain 20364138

Relevant External Links for JAKMIP3 Gene

HapMap Linkage Disequilibrium report
JAKMIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAKMIP3 Gene

Disorders for JAKMIP3 Gene

Relevant External Links for JAKMIP3

Genetic Association Database (GAD)
JAKMIP3
Human Genome Epidemiology (HuGE) Navigator
JAKMIP3

No disorders were found for JAKMIP3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for JAKMIP3 Gene

Publications for JAKMIP3 Gene

  1. Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PMID: 17572408) Cruz-Garcia D. … Malagon M.M. (FEBS Lett. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PMID: 15277531) Steindler C. … Pellegrini S. (J. Biol. Chem. 2004) 2 3
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for JAKMIP3 Gene

Sources for JAKMIP3 Gene

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