JAKMIP3 Gene
protein-coding GIFtS: 44
GCID: GC10P133918
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Janus kinase and microtubule interacting protein 3(Previous names: chromosome 10 open reading frame 39, chromosome 10 open...)
(Previous symbols: C10orf39, C10orf14)
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Aliases
for JAKMIP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Janus Kinase And Microtubule Interacting Protein 31 2 | | KIAA40911 | | C10orf141 2 3 | | Chromosome 10 Open Reading Frame 141 | | C10orf391 2 3 | | Chromosome 10 Open Reading Frame 391 | | NECC21 2 3 | | Jamip32 | | BA140A10.51 | | Janus Kinase And Microtubule-Interacting Protein 32 | | Neuroendocrine Long Coiled-Coil Protein 22 3 | | Neuroendocrine Long Coiled-Coil 22 | | FLJ378571 | | JAMIP33 |
Export aliases for JAKMIP3 gene to outside databasesPrevious GC identifers: GC10P133769 GC10P127467 |
Summaries
for JAKMIP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for JAKMIP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JAKMIP3 gene promoter:
GR GR-beta POU3F2 (N-Oct-5b) HNF-4alpha2 HNF-4alpha1 RORalpha2 AREB6 COMP1 GR-alpha ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for JAKMIP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAKMIP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3JAKMIP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P133918: view genomic region
(about GC identifiers)
Start:
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133,918,175 bp from pter |
End:
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133,998,313 bp from pter |
Size:
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80,139 bases |
Orientation:
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plus strand |
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Proteins
for JAKMIP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66 (See
protein sequence)Recommended Name: Janus kinase and microtubule-interacting protein 3 Size: 844 amino acids; 98529 Da
Subcellular location: Golgi apparatus (By similarity)
Sequence caution: Sequence=BAC86766.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAH10388.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH10388.1;Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: A6PW00 Q69YM6 Q6ZT29Alternative splicing: 2 isoforms: Q5VZ66-1 Q5VZ66-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for JAKMIP3: NX_Q5VZ66
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VZ66
JAKMIP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001098991.1
ENSEMBL proteins: ENSP00000298622
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005794 | Golgi apparatus |
IEA | -- |
JAKMIP3 for ontologies About GeneDecksing
JAKMIP3 Antibody Products:
Assay Products for JAKMIP3: |
Protein
Domains /
Families
for JAKMIP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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JAKMIP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VZ66ProtoNet protein and cluster: Q5VZ66 UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66Similarity: Belongs to the JAKMIP family |
Function
for JAKMIP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAKMIP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAKMIP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for JAKMIP3 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008017 | microtubule binding |
IEA | -- | | GO:0019900 | kinase binding |
IEA | -- |
JAKMIP3 for ontologies About GeneDecksing
|
Pathways & Interactions
for JAKMIP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JAKMIP3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for JAKMIP3 (ENSP000002986224) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for JAKMIP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JAKMIP3
Search CenterWatch for drugs/clinical trials and news about JAKMIP3 / JKIP3
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Transcripts
for JAKMIP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JAKMIP3 gene (3 alternative transcripts): NM_001105521.2 NM_001104947.1 NM_194303.1 Unigene Cluster for JAKMIP3: Janus kinase and microtubule interacting protein 3 Hs.106254 [show with all ESTs]Unigene Representative Sequence: NM_0011055212 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298622(uc001lkx.4) ENST00000477275(uc009yba.1 uc001lky.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAKMIP3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAKMIP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JAKMIP3 (NM_001105521) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JAKMIP3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP3 |
Additional cDNA sequence: AK095176.1 AK097818.1 AL137551.1 BC045170.2 6 DOTS entries: DT.91836755 DT.101977770 DT.406922 DT.99930444 DT.121221343 DT.121221354 16 AceView cDNA sequences: AL137551 NM_194303 AK126964 AK097818 AI018214 BG699792 BC045170 AK123426 AK095176 BF060906 AL832756 BU726775 R20220 R36918 R43308 BQ071550
GeneLoc Exon Structure
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Expression
for JAKMIP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JAKMIP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAAGCAGTA
About this image
See JAKMIP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JAKMIP3
SOURCE GeneReport for Unigene cluster: Hs.106254
UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66Tissue specificity: Specifically expressed in the CNS and endocrine tissues. Also detected in other tissues includingheart, testis and prostate
SABiosciences Custom PCR Arrays for JAKMIP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JAKMIP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat JAKMIP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAKMIP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP3 |
Orthologs
for JAKMIP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for JAKMIP3 gene from 3/11 species (see all 11) About this table
ENSEMBL Gene Tree for JAKMIP3 (if available)
TreeFam Gene Tree for JAKMIP3 (if available) |
Paralogs
for JAKMIP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for JAKMIP3 gene
- JAKMIP12 JAKMIP22
2 SIMAP similar genes for JAKMIP3 using alignment to 1 protein entry: JKIP3_HUMAN:JAKMIP1 JAKMIP2
JAKMIP3 for paralogs About GeneDecksing
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Genomic Variants
for JAKMIP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JAKMIP3 (133918175 - 133998313 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for JAKMIP3
2 CNVs: 4717 71168
7 Indels: 85544 75439 85543 75440 42626 44695 101088 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JAKMIP3 |
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Disorders
/ Diseases
for JAKMIP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
JAKMIP3 for disorders About GeneDecksing
OMIM gene information: 611198
OMIM disorders: --
2  diseases for JAKMIP3: About MalaCardsalzheimer's disease prostatitis
Human Genome Epidemiology (HuGE) Navigator: JAKMIP3 (1 document)
Export disorders for JAKMIP3 gene to outside databases
|
Publications
for JAKMIP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JAKMIP3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with JAKMIP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PubMed id 17572408)1, 2, 3 Cruz-Garcia D.... Malagon M.M. (2007)
- Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)1, 3 Steindler C....Pellegrini S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for JAKMIP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing JAKMIP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JAKMIP3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing JAKMIP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JAKMIP3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for JAKMIP3 gene:
Search GeneIP for patents involving JAKMIP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JAKMIP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | JAKMIP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP3 |
|  |  |  | | | | ThermoFisher Antibodies for JAKMIP3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP3 |
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