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JAKMIP3 Gene

protein-coding GIFtS: 40

GC10P133769

Janus kinase and microtubule interacting protein 3
(Previous names: chromosome 10 open reading frame 39, chromosome 10 open reading frame 14 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: C10orf39, C10orf14)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C10orf14 ^²
C10orf39 ^², ³
FLJ37857 ^¹, ²
FLJ41432 ^²
JAMIP3 ^³
Jamip3 ^²
KIAA4091 ^¹
NECC2 ^¹, ², ³
bA140A10.5 ^¹, ²

Descriptions
Janus kinase and microtubule interacting protein 3 ^²
Neuroendocrine long coiled-coil protein 2 ^³
chromosome 10 open reading frame 14 ^¹
chromosome 10 open reading frame 39 ^¹
neuroendocrine long coiled-coil 2 ^²

External Ids
HGNC: 23523¹
Entrez Gene: 282973²
UniProtKB: Q5VZ66³
Ensembl: ENSG00000188385⁷

Search outside databases for aliases for JAKMIP3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3

JAKMIP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P133769: (about GC identifiers)

Start:	133,768,303 bp from pter
End:	133,848,302 bp from pter
Size:	80,000 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_017795.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66 (See protein sequence)

Recommended Name: Janus kinase and microtubule-interacting protein 3

Size: 844 amino acids; 98529 Da

Subcellular location: Golgi apparatus (By similarity)

Sequence caution: Sequence=CAH10388.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Sequence=CAO03384.1; Type=Erroneous gene model prediction;

Secondary accessions: A6PW00 Q69YM6 Q6ZT29

Alternative splicing: 2 isoforms: Q5VZ66-1 Q5VZ66-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001098991.1

ENSEMBL proteins:

ENSP00000298622 ENSP00000298624

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--

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Antibodies for JAKMIP3:

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Assays for JAKMIP3:

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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q5VZ66

UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66

Similarity: Belongs to the JAKMIP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAKMIP3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_194303

Applied Biosystems Silencer® siRNAs for JAKMIP3

Sigma-Aldrich siRNA for JAKMIP3

Sigma-Aldrich shRNA for JAKMIP3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001105521
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001105521
untagged cDNA clones in CMV expression vector (see all 2): NM_001105521

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001105521

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/14 Interacting proteins for JAKMIP3 (ENSP00000298622³) via UniProtKB, MINT, and/or STRING (see all 14 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP2B3	ENSP00000343886³	STRING (score=.899)
HDAC1	ENSP00000362649³	STRING (score=.899)
HDAC2	ENSP00000357621³	STRING (score=.899)
MEF2A	ENSP00000284368³	STRING (score=.899)
MEF2B	ENSP00000162023³	STRING (score=.899)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JAKMIP3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAKMIP3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_194303

Sigma-Aldrich siRNA for JAKMIP3

Sigma-Aldrich shRNA for JAKMIP3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001105521

REFSEQ mRNAs for JAKMIP3 gene:

NM_001105521.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001105521

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001105521
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001105521
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001105521

Additional cDNA sequence:

AK095176.1 AK097818.1 AL137551.1 BC045170.2

6 DOTS entries:

DT.91836755 DT.101977770 DT.406922 DT.99930444 DT.121221343 DT.121221354

16 AceView cDNA sequences:

AK126964 AL137551 AK097818 NM_194303 AI018214 AK123426 BC045170 AL832756

BF060906 AK095176 BG699792 R20220 R36918 BU726775 R43308 BQ071550

Unigene Cluster for JAKMIP3:

Janus kinase and microtubule interacting protein 3

Hs.106254 [show with all ESTs]

Unigene Representative Sequence: NM_001105521

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000298622 ENST00000298624

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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JAKMIP3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JAKMIP3

¹ / ²

3 probe-sets matching JAKMIP3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
42327_at²	U95-B	1	1.00	1.00	1.00	1.00	--	--	--	--	--
233076_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
233076_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks JAKMIP3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTAAGCAGTA

SOURCE GeneReport for Unigene cluster: Hs.106254
UniProtKB/Swiss-Prot: JKIP3_HUMAN, Q5VZ66
Tissue specificity: Specifically expressed in the CNS and endocrine tissues. Also detected in other
tissues including heart, testis and prostate

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for JAKMIP3 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	JAKMIP3¹	--	janus kinase and microtubule interacting protein 3	97.51(n) 96.84(a)	746803 XM_001154925.1 XP_001154925.1
cow (Bos taurus)	JAKMIP3¹	--	janus kinase and microtubule interacting protein 3	88.97(n) 93.84(a)	614810 XM_866446.2 XP_871539.2
mouse (Mus musculus)	Jakmip3⁵	7	janus kinase and microtubule interacting protein 3	--	BC119558
chicken (Gallus gallus)	C10orf39¹	--	chromosome 10 open reading frame 39	81.96(n) 89.68(a)	428991 XM_426548.2 XP_426548.2

About this table Species with no ortholog for JAKMIP3

ENSEMBL Gene Tree for JAKMIP3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for JAKMIP3 gene

JAKMIP1² JAKMIP2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/668 NCBI SNPs in JAKMIP3 are shown (see all 668 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11592585^1,2	A,C,F,H	133805417(+)	`AGGGCA/GTGGCC`	1	M/V	mis¹		4		EU EA WA	394
--	rs10870249^1,2	A,C,F,H	133767689(+)	`CGCTTC/TTGTTC`	1	--	ng5¹		4		EU EA WA	406
--	rs12218716^1,2	C,F,H	133766677(+)	`GCTTTT/CTTCCC`	1	--	ng5¹ trp³		4		EU EA WA	418
--	rs10870250^1,2	A,F,H	133767831(+)	`CTCACA/CGCCAT`	1	--	ng5¹		3		EU EA	284
--	rs12249383^1,2	A,F,H	133766749(+)	`AGAGGA/GGCCCA`	1	--	ng5¹		4		EU EA WA	388
--	rs9419366^1,2	A,F,H	133767582(+)	`TTCTGC/TTACGT`	1	--	ng5¹		4		EU EA WA	404
--	rs9419367^1,2	A,F,H	133767721(+)	`ctgggC/TatTTC`	1	--	ng5¹ tfbs³		4		EU EA WA	416
--	rs9419193^1,2	A,C	133766490(+)	`AGATGC/GGGGCG`	1	--	ng5¹		0	--	--	--	--
--	rs9419197^1,2	F,H	133767207(+)	`tggatT/Cggtgc`	1	--	ng5¹		4		EU EA WA	384
--	rs9419194^1,2	F,H	133767061(+)	`CAGAAG/AGAAAG`	1	--	ng5¹ trp³		4		EU EA WA	402

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HapMap Linkage Disequilibrium images for JAKMIP3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 611198

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for JAKMIP3 gene:

Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PubMed id 17572408)^{2, 3, 4} Cruz-Garcia D....Malagon M.M. (2007)
Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)^{2, 3} Steindler C....Pellegrini S. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)⁴ Sjoeblom T.... Velculescu V.E. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 282973	HGNC: 23523	AceView: C10orf39	Ensembl:ENSG00000188385	euGenes: HUgn282973
ECgene: JAKMIP3	H-InvDB: JAKMIP3

(According to HUGE)
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HUGE: KIAA4091

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for JAKMIP3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for JAKMIP3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JAKMIP3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

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JAKMIP3 Gene

protein-coding GIFtS: 40

Aliases &
Descriptions
for JAKMIP3

Summaries
for JAKMIP3

Genomic Location
for JAKMIP3

Proteins
for JAKMIP3

Protein Domains/
Families
for JAKMIP3

Gene Function
for JAKMIP3

Pathways & Interactions
for JAKMIP3

Drugs & Compounds
for JAKMIP3

Transcripts
for JAKMIP3

Expression
for JAKMIP3

Orthologs
for JAKMIP3

Paralogs
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SNPs/Variants
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Disorders & Mutations
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Medical News
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Publications
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Genome Databases showing JAKMIP3

Other Databases showing JAKMIP3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JAKMIP3 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor JAKMIP3

Summariesfor JAKMIP3

Genomic Locationfor JAKMIP3

Proteinsfor JAKMIP3

Protein Domains/Familiesfor JAKMIP3

Gene Functionfor JAKMIP3

Pathways & Interactionsfor JAKMIP3

Drugs & Compoundsfor JAKMIP3

Transcriptsfor JAKMIP3

Expression for JAKMIP3

Orthologsfor JAKMIP3

Paralogsfor JAKMIP3

SNPs/Variantsfor JAKMIP3

Disorders & Mutationsfor JAKMIP3

Medical Newsfor JAKMIP3

Publicationsfor JAKMIP3

Search for JAKMIP3

Genome Databases showing JAKMIP3

Other Databases showing JAKMIP3

Specialized Databases showing JAKMIP3

Licensable Technologiesfor JAKMIP3

Servicesfor JAKMIP3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JAKMIP3

Summaries
for JAKMIP3

Genomic Location
for JAKMIP3

Proteins
for JAKMIP3

Protein Domains/
Families
for JAKMIP3

Gene Function
for JAKMIP3

Pathways & Interactions
for JAKMIP3

Drugs & Compounds
for JAKMIP3

Transcripts
for JAKMIP3

Expression
for JAKMIP3

Orthologs
for JAKMIP3

Paralogs
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SNPs/Variants
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Disorders & Mutations
for JAKMIP3

Medical News
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