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JAKMIP2 Gene

protein-coding GIFtS: 46

GC05M146949

Janus kinase and microtubule interacting protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
JAMIP2 ^¹, ², ³
KIAA0555 ^¹, ², ³
NECC1 ^², ³

Descriptions
CTCL tumor antigen HD-CL-04 ^³
Jak and microtubule interacting protein 2 ^²
Janus kinase and microtubule interacting protein 2 ^²
Neuroendocrine long coiled-coil protein 1 ^², ³
neuroendocrine long coiled-coil 1 ^²

External Ids
HGNC: 29067¹
Entrez Gene: 9832²
UniProtKB: Q96AA8³
Ensembl: ENSG00000176049⁷

Search outside databases for aliases for JAKMIP2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the JAKMIP2 gene

Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q32

JAKMIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M146949: (about GC identifiers)

Start:	146,950,899 bp from pter
End:	147,142,445 bp from pter
Size:	191,547 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JKIP2_HUMAN, Q96AA8 (See protein sequence)

Recommended Name: Janus kinase and microtubule-interacting protein 2

Size: 810 amino acids; 94934 Da

Subcellular location: Golgi apparatus

Sequence caution: Sequence=BAA25481.2; Type=Frameshift; Positions=805;

Secondary accessions: A4ZZA7 A8K5G5 O60302 Q548S1

Alternative splicing: 3 isoforms: Q96AA8-1 Q96AA8-2 Q96AA8-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055605.2

ENSEMBL proteins:

ENSP00000377924 ENSP00000377922 ENSP00000328989 ENSP00000265272

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (JAKMIP2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--

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Antibodies for JAKMIP2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (JAKMIP2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for JAKMIP2

Assays for JAKMIP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q96AA8

UniProtKB/Swiss-Prot: JKIP2_HUMAN, Q96AA8

Similarity: Belongs to the JAKMIP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAKMIP2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014790

Applied Biosystems Silencer® siRNAs for JAKMIP2

Sigma-Aldrich siRNA for JAKMIP2

Sigma-Aldrich shRNA for JAKMIP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for JAKMIP2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014790
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014790
untagged cDNA clones in CMV expression vector (see all 3): NM_014790

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014790

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for JAKMIP2 (ENSP00000265272³ Q96AA8²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRIM29	Q14134²	MINT-68356
HOPX	ENSP00000370659³	STRING (score=.831)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JAKMIP2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAKMIP2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014790

Sigma-Aldrich siRNA for JAKMIP2

Sigma-Aldrich shRNA for JAKMIP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014790

REFSEQ mRNAs for JAKMIP2 gene:

NM_014790.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014790

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014790
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014790
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_014790

Additional cDNA sequence:

AB011127.1 AF273057.1 AK291280.1 AK299724.1 BC003189.1 BC017354.2 EF512550.1

6 DOTS entries:

DT.100813089 DT.213997 DT.213998 DT.120873938 DT.97784865 DT.91661708

24/59 AceView cDNA sequences (see all 59 ):

AL137976 Z42539 AF273057 NM_014790 BM674562 BE792187 BC017354 AI417140

BC003189 AA256692 N22187 BM701563 AA234271 BE501299 AA356433 AI352492

BE266599 AA436379 AL515948 AW006280 BQ723088 AI962693 BX118477 BX952999

highest scoring ESTs for JAKMIP2:

AB011127 AF273057 BC003189 BC017354 BI115202 BI667896 BX491453 AA135524 AA135585 AA234271

Unigene Cluster for JAKMIP2:

Janus kinase and microtubule interacting protein 2

Hs.719177 [show with all ESTs]

Unigene Representative Sequence: AB011127

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000394401 ENST00000394399 ENST00000333010 ENST00000265272

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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JAKMIP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JAKMIP2

¹ / ² / ³

5 probe-sets matching JAKMIP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39952_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB011127	1.00	1.00	1.00	1
205889_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014790	0.60	1.00	0.82	1
205888_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI962693	0.60	1.00	0.82	1
205889_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205888_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTTTTCCCT

SOURCE GeneReport for Unigene cluster: Hs.719177
UniProtKB/Swiss-Prot: JKIP2_HUMAN, Q96AA8
Tissue specificity: Highly expressed in brain, moderately expressed in thymus, spleen and lung, and
weakly expressed in kidney, liver and peripheral blood lymphocytes. Aslo expressed in adrenal and
pituitary glands, as well as testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for JAKMIP2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JAKMIP2¹	--	janus kinase and microtubule interacting protein 2	94.53(n) 99.38(a)	478054 XM_854063.1 XP_859156.1
chimpanzee (Pan troglodytes)	JAKMIP2¹	--	janus kinase and microtubule interacting protein 2	99.63(n) 100(a)	462172 XM_518021.2 XP_518021.2
cow (Bos taurus)	JAKMIP2¹	--	janus kinase and microtubule interacting protein 2	94.07(n) 99.63(a)	527239 NM_001075897.1 NP_001069365.1
rat (Rattus norvegicus)	Jakmip2¹	--	janus kinase and microtubule interacting protein 2	89.42(n) 96.54(a)	307479 XM_225987.4 XP_225987.4
mouse (Mus musculus)	Jakmip2^{1, 5}	18⁵	janus kinase and microtubule interacting protein 2^{1, 5}	90.21(n)¹ 98.77(a)¹	76217¹ XM_129010.6¹ XP_129010.4¹ AA591628⁵ AI850334⁵ (see all 14)

About this table Species with no ortholog for JAKMIP2

ENSEMBL Gene Tree for JAKMIP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for JAKMIP2 gene

JAKMIP3² JAKMIP1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/573 NCBI SNPs in JAKMIP2 are shown (see all 573 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 320)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs32204^1,2	A,C,F,H,O	147143113(+)	`TTTCCA/GGCTAC`	1	--	ng3¹		4		EU EA WA	418
	rs2436340^1,2	A,C,F,H	147142668(-)	`AGACCC/TTGCAG`	1	--	ng3¹		8		EU EA WA	836
	rs2436426^1,2	C,F,H	147143970(+)	`ATAATT/CTGGAA`	1	--	ng3¹		4		EU EA WA	416
--	rs13178431^1,2	C,F,H	147143138(+)	`CTTGGA/GGGTAA`	1	--	ng3¹		4		EU EA WA	418
	rs6873548^1,2	F,H	147142758(+)	`TGGGGC/TAAGGG`	1	--	ng3¹		4		EU EA WA	376
	rs12109699^1,2	F,H	147143950(+)	`CGCCAG/CTATTT`	1	--	ng3¹		4		EU EA WA	418
--	rs7704731^1,2	A,C	147143494(-)	`TACTAC/TATGCC`	1	--	ng3¹		0	--	--	--	--
	rs1432830^1,2	A,C,F,H,O	147059008(+)	`GAGTAT/GGTGTT`	1	--	int¹		11		EU EA WA NA	960
	rs2288826^1,2	A,C,F,H,O	147045766(-)	`GCTTCG/AGCTGG`	1	--	int¹		12		EA EU WA NA	2460
	rs1432831^1,2	A,C,F,H,O	147032361(+)	`TCTACG/ATCACC`	1	--	int¹		11		NA EU EA WA	980

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HapMap Linkage Disequilibrium images for JAKMIP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 611197

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10 PubMed articles for JAKMIP2 gene:

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{2, 3, 4} Nagase T....Ohara O. (1998)
Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PubMed id 17572408)^{3, 4} Cruz-Garcia D....Malagon M.M. (2007)
SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095)^{3, 4} Hartmann T.B.... Eichmueller S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)⁴ Sjoeblom T.... Velculescu V.E. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)⁴ Steindler C....Pellegrini S. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Marlin-1, a novel RNA-binding protein associates with GABA receptors. (PubMed id 14718537)³ Couve A.... Moss S.J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9832	HGNC: 29067	AceView: KIAA0555	Ensembl:ENSG00000176049	euGenes: HUgn9832
ECgene: JAKMIP2	H-InvDB: JAKMIP2

(According to HUGE)
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HUGE: KIAA0555

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for JAKMIP2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for JAKMIP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JAKMIP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JAKMIP2		Browse antibodies at Sigma-Aldrich
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JAKMIP2 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for JAKMIP2

Summaries
for JAKMIP2

Genomic Location
for JAKMIP2

Proteins
for JAKMIP2

Protein Domains/
Families
for JAKMIP2

Gene Function
for JAKMIP2

Pathways & Interactions
for JAKMIP2

Drugs & Compounds
for JAKMIP2

Transcripts
for JAKMIP2

Expression
for JAKMIP2

Orthologs
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Paralogs
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SNPs/Variants
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Disorders & Mutations
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Medical News
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Publications
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Genome Databases showing JAKMIP2

Other Databases showing JAKMIP2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JAKMIP2 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor JAKMIP2

Summariesfor JAKMIP2

Genomic Locationfor JAKMIP2

Proteinsfor JAKMIP2

Protein Domains/Familiesfor JAKMIP2

Gene Functionfor JAKMIP2

Pathways & Interactionsfor JAKMIP2

Drugs & Compoundsfor JAKMIP2

Transcriptsfor JAKMIP2

Expression for JAKMIP2

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SNPs/Variantsfor JAKMIP2

Disorders & Mutationsfor JAKMIP2

Medical Newsfor JAKMIP2

Publicationsfor JAKMIP2

Search for JAKMIP2

Genome Databases showing JAKMIP2

Other Databases showing JAKMIP2

Specialized Databases showing JAKMIP2

Licensable Technologiesfor JAKMIP2

Servicesfor JAKMIP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JAKMIP2

Summaries
for JAKMIP2

Genomic Location
for JAKMIP2

Proteins
for JAKMIP2

Protein Domains/
Families
for JAKMIP2

Gene Function
for JAKMIP2

Pathways & Interactions
for JAKMIP2

Drugs & Compounds
for JAKMIP2

Transcripts
for JAKMIP2

Expression
for JAKMIP2

Orthologs
for JAKMIP2

Paralogs
for JAKMIP2

SNPs/Variants
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Disorders & Mutations
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Medical News
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