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Aliases for JAKMIP2 Gene

Aliases for JAKMIP2 Gene

  • Janus Kinase And Microtubule Interacting Protein 2 2 3 5
  • Neuroendocrine Long Coiled-Coil Protein 1 3 4
  • CTCL Tumor Antigen HD-CL-04 3 4
  • JAMIP2 3 4
  • NECC1 3 4
  • Janus Kinase And Microtubule-Interacting Protein 2 3
  • Jak And Microtubule Interacting Protein 2 3
  • KIAA0555 4

External Ids for JAKMIP2 Gene

Previous GeneCards Identifiers for JAKMIP2 Gene

  • GC05M146949
  • GC05M142117

Summaries for JAKMIP2 Gene

Entrez Gene Summary for JAKMIP2 Gene

  • The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for JAKMIP2 Gene

JAKMIP2 (Janus Kinase And Microtubule Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding and kinase binding. An important paralog of this gene is JAKMIP1.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAKMIP2 Gene

Genomics for JAKMIP2 Gene

Regulatory Elements for JAKMIP2 Gene

Enhancers for JAKMIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G147780 1.1 Ensembl ENCODE 18.6 +1.2 1164 3.4 BMI1 ZNF2 RAD21 ZEB1 GLIS2 ZNF366 KLF7 ZNF263 SP3 ZNF362 JAKMIP2 LOC105378218
GH05G147804 1.1 FANTOM5 Ensembl ENCODE 13.7 -22.3 -22284 1.5 CEBPB CEBPG TBX21 GABPA EGR1 ETV6 FOXP2 MYC SPI1 JAKMIP2 SPINK14 GC05P147800 GC05M147757
GH05G147837 1.3 FANTOM5 ENCODE 10.7 -55.7 -55668 1.9 ELF3 HNRNPUL1 FOXA2 DNMT3B ZSCAN9 RARA GATA4 CREM MIXL1 THAP11 JAKMIP2 SPINK1 GC05M147824
GH05G147565 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.1 +215.1 215099 4.4 CTCF USF1 CBX3 CHD7 RAD21 ZNF664 POLR2A SMC3 HNF4G FOS JAKMIP2 DPYSL3 JAKMIP2-AS1 LOC101927012
GH05G147822 0.7 ENCODE 11.2 -40.0 -40015 0.1 ZNF263 CTCF ZNF654 ESRRA ZNF777 CBFB TRIM22 EP300 RAD21 ZNF518A JAKMIP2 ENSG00000251320 ENSG00000248362 GC05M147824 GC05M147757
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around JAKMIP2 on UCSC Golden Path with GeneCards custom track

Promoters for JAKMIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000188600 747 1400 BMI1 ZNF2 ZEB1 GLIS2 ZNF366 KLF7 ZNF263 SP3 ZNF362 REST

Genomic Location for JAKMIP2 Gene

Chromosome:
5
Start:
147,585,439 bp from pter
End:
147,782,848 bp from pter
Size:
197,410 bases
Orientation:
Minus strand

Genomic View for JAKMIP2 Gene

Genes around JAKMIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAKMIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAKMIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAKMIP2 Gene

Proteins for JAKMIP2 Gene

  • Protein details for JAKMIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AA8-JKIP2_HUMAN
    Recommended name:
    Janus kinase and microtubule-interacting protein 2
    Protein Accession:
    Q96AA8
    Secondary Accessions:
    • A4ZZA7
    • A8K5G5
    • B4DSG0
    • G5E9Y0
    • O60302
    • Q548S1

    Protein attributes for JAKMIP2 Gene

    Size:
    810 amino acids
    Molecular mass:
    94934 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25481.2; Type=Frameshift; Positions=805; Evidence={ECO:0000305};

    Alternative splice isoforms for JAKMIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAKMIP2 Gene

Post-translational modifications for JAKMIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for JAKMIP2 Gene

Domains & Families for JAKMIP2 Gene

Protein Domains for JAKMIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for JAKMIP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AA8

UniProtKB/Swiss-Prot:

JKIP2_HUMAN :
  • Belongs to the JAKMIP family.
Family:
  • Belongs to the JAKMIP family.
genes like me logo Genes that share domains with JAKMIP2: view

No data available for Gene Families for JAKMIP2 Gene

Function for JAKMIP2 Gene

Gene Ontology (GO) - Molecular Function for JAKMIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with JAKMIP2: view

Phenotypes for JAKMIP2 Gene

GenomeRNAi human phenotypes for JAKMIP2:
genes like me logo Genes that share phenotypes with JAKMIP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for JAKMIP2 Gene

Localization for JAKMIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAKMIP2 Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for JAKMIP2 gene
Compartment Confidence
golgi apparatus 5
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for JAKMIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with JAKMIP2: view

Pathways & Interactions for JAKMIP2 Gene

SuperPathways for JAKMIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for JAKMIP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for JAKMIP2 Gene

Drugs & Compounds for JAKMIP2 Gene

No Compound Related Data Available

Transcripts for JAKMIP2 Gene

Unigene Clusters for JAKMIP2 Gene

Janus kinase and microtubule interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP2 Gene

No ASD Table

Relevant External Links for JAKMIP2 Gene

GeneLoc Exon Structure for
JAKMIP2
ECgene alternative splicing isoforms for
JAKMIP2

Expression for JAKMIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for JAKMIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for JAKMIP2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5) and Brain - Cerebellum (x4.0).

Protein differential expression in normal tissues from HIPED for JAKMIP2 Gene

This gene is overexpressed in Ovary (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JAKMIP2 Gene



Protein tissue co-expression partners for JAKMIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of JAKMIP2 Gene:

JAKMIP2

SOURCE GeneReport for Unigene cluster for JAKMIP2 Gene:

Hs.744926

mRNA Expression by UniProt/SwissProt for JAKMIP2 Gene:

Q96AA8-JKIP2_HUMAN
Tissue specificity: Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Also expressed in adrenal and pituitary glands, as well as testis.

Evidence on tissue expression from TISSUES for JAKMIP2 Gene

  • Nervous system(4.4)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with JAKMIP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for JAKMIP2 Gene

Orthologs for JAKMIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for JAKMIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAKMIP2 34 35
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia JAKMIP2 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JAKMIP2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAKMIP2 34 35
  • 94.84 (n)
cow
(Bos Taurus)
Mammalia JAKMIP2 34 35
  • 94.19 (n)
rat
(Rattus norvegicus)
Mammalia Jakmip2 34
  • 90.88 (n)
mouse
(Mus musculus)
Mammalia Jakmip2 16 35 34
  • 90.57 (n)
chicken
(Gallus gallus)
Aves JAKMIP2 35 34
  • 82.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JAKMIP2 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jakmip2 34
  • 77.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8504 34
zebrafish
(Danio rerio)
Actinopterygii jakmip2 34 35
  • 70.7 (n)
Species where no ortholog for JAKMIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for JAKMIP2 Gene

ENSEMBL:
Gene Tree for JAKMIP2 (if available)
TreeFam:
Gene Tree for JAKMIP2 (if available)

Paralogs for JAKMIP2 Gene

Paralogs for JAKMIP2 Gene

(2) SIMAP similar genes for JAKMIP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with JAKMIP2: view

Variants for JAKMIP2 Gene

Sequence variations from dbSNP and Humsavar for JAKMIP2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs761359853 A colorectal cancer sample 147,644,990(+) CACAC(A/G)TTTTA intron-variant, reference, missense
rs1000017751 -- 147,775,402(+) TATAA(C/T)TTGCT intron-variant
rs1000023369 -- 147,743,867(+) TGGAG(A/G)CTGGC intron-variant
rs1000063890 -- 147,656,118(+) ATTAT(A/G)TGGTT intron-variant
rs1000063922 -- 147,782,667(+) GCGGC(A/G)GCAGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for JAKMIP2 Gene

Variant ID Type Subtype PubMed ID
esv2454562 CNV insertion 19546169
esv3570486 CNV loss 25503493
nsv1021356 CNV gain 25217958
nsv1117591 CNV deletion 24896259
nsv5056 CNV insertion 18451855

Variation tolerance for JAKMIP2 Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 39.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JAKMIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
JAKMIP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAKMIP2 Gene

Disorders for JAKMIP2 Gene

Relevant External Links for JAKMIP2

Genetic Association Database (GAD)
JAKMIP2
Human Genome Epidemiology (HuGE) Navigator
JAKMIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
JAKMIP2

No disorders were found for JAKMIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for JAKMIP2 Gene

Publications for JAKMIP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen L.L. … Saavalainen P. (Tissue Antigens 2009) 3 46 64
  4. Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PMID: 17572408) Cruz-Garcia D. … Malagon M.M. (FEBS Lett. 2007) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for JAKMIP2 Gene

Sources for JAKMIP2 Gene

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