Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

JAKMIP1 Gene

protein-coding GIFtS: 52
GCID: GC04M005962

Janus Kinase And Microtubule Interacting Protein 1

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Janus Kinase And Microtubule Interacting Protein 1¹ ²		Jak And Microtubule Interacting Protein 1²
Multiple Alpha-Helices And RNA-Linker Protein 1² ³		Janus Kinase And Microtubule-Interacting Protein 1²
JAMIP1² ³		marlin-1²
MARLIN1² ³		Multiple Coiled-Coil GABABR1-Binding Protein²
GABA-B Receptor-Binding Protein² ³		GABABRBP³
Gababrbp²		Marlin-1³

External Ids:	HGNC: 26460¹	Entrez Gene: 152789²	Ensembl: ENSG00000152969⁷	OMIM: 611195⁵	UniProtKB: Q96N16³

Export aliases for JAKMIP1 gene to outside databases

Previous GC identifer: GC04M006106

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for JAKMIP1 Gene:

JAKMIP1 (janus kinase and microtubule interacting protein 1) is a protein-coding gene. Diseases associated with JAKMIP1 include crohn's disease, and breast cancer. GO annotations related to this gene include kinase binding and RNA binding. An important paralog of this gene is JAKMIP3.

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B

receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NT_006051.18 NC_018915.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the JAKMIP1 gene promoter:
AhR Spz1 AML1a p300 AP-4 Arnt AREB6 NF-Y CBF(2) ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JAKMIP1 promoter sequence

Search SABiosciences Chromatin IP Primers for JAKMIP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAKMIP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1

JAKMIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAKMIP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M005962: view genomic region (about GC identifiers)

Start:	6,027,926 bp from pter	End:	6,202,318 bp from pter
Size:	174,393 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 (See protein sequence)

Recommended Name: Janus kinase and microtubule-interacting protein 1

Size: 626 amino acids; 73209 Da

Subunit: Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2

Subcellular location: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the

microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in

granules. Localizes to the tail and to a lower extent to the head of sperm cells

Caution: Was originally (PubMed:14718537) thought to bind single-stranded RNA molecules and regulate GABA-B

receptor expression

Sequence caution: Sequence=BAC05325.1; Type=Erroneous termination; Positions=285; Note=Translated as Arg;

Sequence=BAC05325.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: A6H2J2 A6H2J3 A6H2J4 A6H2J5 A8MTK6 B8ZZR7 D3DVT0 Q86Y69 Q8N7G3

Alternative splicing: 6 isoforms: Q96N16-1 Q96N16-2 Q96N16-3 Q96N16-4 Q96N16-5 Q96N16-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JAKMIP1: NX_Q96N16

Explore proteomics data for JAKMIP1 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96N16

JAKMIP1 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001092903.1 NP_653321.1

ENSEMBL proteins:

ENSP00000386711 ENSP00000387042 ENSP00000422004 ENSP00000282924 ENSP00000386925

ENSP00000386745

Human Recombinant Protein Products for JAKMIP1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for JAKMIP1 OriGene Custom MassSpec OriGene Custom Protein Services for JAKMIP1
	GenScript Custom Purified and Recombinant Proteins Services for JAKMIP1
	Novus Biologicals JAKMIP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for JAKMIP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0019898	extrinsic to membrane	IDA	14718537
GO:0030529	ribonucleoprotein complex	IDA	14718537

JAKMIP1 for ontologies About GeneDecksing

JAKMIP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for JAKMIP1
	GenScript Custom Superior Antibodies Services for JAKMIP1
	Novus Biologicals JAKMIP1 Antibodies
	Abcam antibodies for JAKMIP1
	Cloud-Clone Corp. Antibodies for JAKMIP1
	ThermoFisher Antibodies for JAKMIP1
	LSBio Antibodies in human, mouse, rat for JAKMIP1

Assay Products for JAKMIP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for JAKMIP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for JAKMIP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for JAKMIP1 Cloud-Clone Corp. CLIAs for JAKMIP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro protein domain:

IPR024836 JAKMIP

Graphical View of Domain Structure for InterPro Entry Q96N16

ProtoNet protein and cluster: Q96N16

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Similarity: Belongs to the JAKMIP family

JAKMIP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: JKIP1_HUMAN, Q96N16

Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B

receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	14718537
GO:0008017	microtubule binding	IEA	--
GO:0019894	kinesin binding	IEA	--
GO:0019900	kinase binding	IEA	--
GO:0050811	GABA receptor binding	IDA	14718537

JAKMIP1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for JAKMIP1

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JAKMIP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JAKMIP1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JAKMIP1

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JAKMIP1
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate JAKMIP1 (see all 32):
		hsa-miR-3910 hsa-miR-34b* hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-449a hsa-miR-124 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: JAKMIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for JAKMIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAKMIP1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for JAKMIP1
			Sirion Biotech Customized adenovirus for overexpression of JAKMIP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for JAKMIP1 (see all 10) OriGene ORF clones in mouse, rat for JAKMIP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): JAKMIP1 (NM_001099433)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAKMIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1
		Sirion Biotech Customized lentivirus for stable overexpression of JAKMIP1 Customized lentivirus expression plasmids for stable overexpression of JAKMIP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for JAKMIP1
		Search LifeMap BioReagents cell lines for JAKMIP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for JAKMIP1 About

See pathways by source

SuperPath

Contained pathways About

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

1 BioSystems Pathway for JAKMIP1

Integrated Breast Cancer Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for JAKMIP1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/11 Interacting proteins for JAKMIP1 (Q96N16³ ENSP00000386711⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000232632	Q9UBS5³, ENSP00000388035⁴	I2D: score=2 STRING: ENSP00000388035
GABBR1	Q9UBS5³, ENSP00000366233⁴	I2D: score=2 STRING: ENSP00000366233
ENSG00000206466	Q9UBS5³	I2D: score=2
ENSG00000206511	Q9UBS5³	I2D: score=2
ENSG00000232569	Q9UBS5³	I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--

JAKMIP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for JAKMIP1 (JKIP1)

Search CenterWatch for drugs/clinical trials and news about JAKMIP1 / JKIP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for JAKMIP1 gene (2 alternative transcripts):

NM_001099433.1 NM_144720.3

Unigene Cluster for JAKMIP1:

Janus kinase and microtubule interacting protein 1

Hs.479066 [show with all ESTs]

Unigene Representative Sequence: NM_001099433

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409021(uc010idb.1 uc010idd.1) ENST00000409371(uc010idc.1)

ENST00000473053(uc010ide.3) ENST00000282924(uc003giv.4) ENST00000409831(uc003giu.4 uc011bwc.2)

ENST00000410077 ENST00000457227

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat JAKMIP1
		8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate JAKMIP1 (see all 32):
		hsa-miR-3910 hsa-miR-34b* hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-449a hsa-miR-124 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: JAKMIP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for JAKMIP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAKMIP1

Clone Products:		OriGene clones in human, mouse for JAKMIP1 (see all 10) OriGene ORF clones in mouse, rat for JAKMIP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): JAKMIP1 (NM_001099433)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAKMIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1
		Sirion Biotech Customized lentivirus for stable overexpression of JAKMIP1 Customized lentivirus expression plasmids for stable overexpression of JAKMIP1

Primer Products:		OriGene qPCR primer pairs and template standards for JAKMIP1 OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat JAKMIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1

Additional mRNA sequence:

AK056126.1 AK098536.1 AK124718.1 AK294356.1 AK295339.1 AK307983.1 AM412307.1 AM412308.1

AM412309.1 AM412310.1 AY382340.1 BC026343.1 BC047075.1

6 DOTS entries:

DT.445810 DT.92020668 DT.101975859 DT.100020164 DT.91977808 DT.95360916

24/31 AceView cDNA sequences (see all 31):

AY382340 AK056126 BQ639074 AL525796 AK098536 AW954559 BM675261 BU617552

NM_144720 Z44031 BM695429 AK124718 BC026343 BP429586 BM689820 BM685608

BC047075 AL525757 BG705618 R42780 AW157571 BI668982 BM714077 H08055

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15
SP1:			-		-
SP2:					-
SP3:							-		-																-

ECgene alternative splicing isoforms for JAKMIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

JAKMIP1 expression in normal human tissues (normalized intensities) JAKMIP1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

JAKMIP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/15 selected tissues (see all 15) fully expand


Eye (Sensory Organs)
retinal amacrine cell p0

Blood Brain Barrier (Nervous System)
Postnatal Endothelial Cells Blood Brain Barrier

Gut Tube (Gastrointestinal Tract)
Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

Inner Cell Mass (Early Embryonic Tissues)
Line H9 (WA09)

Oral Cavity (Gastrointestinal Tract)
oral mucosa ; squamous epithelial cells

See JAKMIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JAKMIP1

SOURCE GeneReport for Unigene cluster: Hs.479066

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Tissue specificity: Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2,

isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected

in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine

SABiosciences Custom PCR Arrays for JAKMIP1

Primer Products:		OriGene qPCR primer pairs and template standards for JAKMIP1 OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat JAKMIP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for JAKMIP1 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Jakmip1^{1 , 5}	janus kinase and microtubule interacting protein 1^{1, 5}	87.49(n)¹ 95.21(a)¹		5 (19.66 cM)⁵ 76071¹ NM_178394.4¹ NP_848481.2¹ 37028335⁵
chicken (Gallus gallus)	Aves	JAKMIP1¹	janus kinase and microtubule interacting protein 1	76.24(n) 84.47(a)		422854 XM_420800.3 XP_420800.3
lizard (Anolis carolinensis)	Reptilia	JAKMIP1⁶	Uncharacterized protein	68(a)	1 ↔ 1	5(80450342-80496717)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX730452.1²	--	74.38(n)		BX730452.1
zebrafish (Danio rerio)	Actinopterygii	JAKMIP3⁶	Uncharacterized protein	65(a)	1 ↔ 1	14(15062644-15122006)

ENSEMBL Gene Tree for JAKMIP1 (if available)
TreeFam Gene Tree for JAKMIP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for JAKMIP1 gene

JAKMIP3² JAKMIP2²

2 SIMAP similar genes for JAKMIP1 using alignment to 3 protein entries: JKIP1_HUMAN (see all proteins):

JAKMIP3 JAKMIP2

JAKMIP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_039472⁴		A colorectal cancer sample⁴	--	see VAR_039472	2	A V	mis⁴		0	--	--	--	--
VAR_039471⁴		--	--	see VAR_039471	2	K R	mis⁴		0	--	--	--	--
rs115436213^1,2	C,F	--	6027436(+)	`CACAGG/TAGTCA`	1	--	ds500¹		1		WA	118
rs9291109^1,2	C,F,H	--	6027465(+)	`GGGTGA/TGACGG`	1	--	ds500¹		13		NA WA CSA	260
rs73196065^1,2	C	--	6027468(+)	`TGTGAC/TGGGGA`	1	--	ds500¹		0	--	--	--	--
rs142255197^1,2		--	6027485(+)	`TGAGTA/GGCTTC`	1	--	ds500¹		0	--	--	--	--
rs151283453^1,2	C	--	6027580(+)	`CCCTCA/GGCCCT`	1	--	ds500¹		0	--	--	--	--
rs139294764^1,2		--	6027586(+)	`GCCCTA/GGAAGC`	1	--	ds500¹		0	--	--	--	--
rs73196066^1,2	C	--	6027646(+)	`GAGCAC/ACAGGG`	1	--	ds500¹		3		NA WA	240
rs189791764^1,2		--	6027696(+)	`AGTCCC/TCCTTT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for JAKMIP1 (6027926 - 6202318 bp)

Structural Variations
Database of Genomic Variants (DGV) 10/27 variations for JAKMIP1 (see all 27): About this table

Variant ID	Type	Subtype	PubMed ID
esv2726988	CNV	Deletion	23290073
esv2324557	CNV	Deletion	18987734
esv2726986	CNV	Deletion	23290073
esv2726985	CNV	Deletion	23290073
esv1003999	CNV	Deletion	20482838
esv998642	CNV	Deletion	20482838
esv2726990	CNV	Deletion	23290073
dgv919e199	CNV	Deletion	23128226
esv2675636	CNV	Deletion	23128226
esv2213984	CNV	Deletion	18987734

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JAKMIP1

DNA2.0 Custom Variant and Variant Library Synthesis for JAKMIP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 611195 OMIM disorders: --

3 diseases for JAKMIP1: About MalaCards

crohn's disease breast cancer neuronitis

JAKMIP1 for disorders About GeneDecksing

Genetic Association Database (GAD): JAKMIP1
Human Genome Epidemiology (HuGE) Navigator: JAKMIP1 (2 documents)

Export disorders for JAKMIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for JAKMIP1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with JAKMIP1)

Utopia: connect your pdf to the dynamic
world of online information

Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)^{1, 2, 9} Steindler C....Pellegrini S. (2004)
Identification and expression analysis of novel Jakmip1 transcripts. (PubMed id 17761393)^{1, 2, 9} Costa V....Ciccodicola A. (2007)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. (PubMed id 18941173)^{1, 3} Libri V....Pellegrini S. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Marlin-1, a novel RNA-binding protein associates with GABA receptors. (PubMed id 14718537)^{1, 2} Couve A.... Moss S.J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)¹ Lauc G....Rudan I. (2013)
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)¹ Turner S.T....Boerwinkle E. (2012)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 152789	HGNC: 26460	AceView: MARLIN1	Ensembl:ENSG00000152969	euGenes: HUgn152789
ECgene: JAKMIP1	H-InvDB: JAKMIP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for JAKMIP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for JAKMIP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for JAKMIP1 gene:
Search GeneIP for patents involving JAKMIP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for JAKMIP1
	OriGene qPCR primer pairs and template standards for JAKMIP1		OriGene Protein Over-expression Lysate for JAKMIP1
	OriGene Custom Mass Spec		OriGene clones in human, mouse for JAKMIP1
	OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for JAKMIP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for JAKMIP1		OriGene Custom Protein Services for JAKMIP1

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat JAKMIP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JAKMIP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAKMIP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat JAKMIP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1

	GenScript Custom Purified and Recombinant Proteins Services for JAKMIP1		GenScript cDNA clones with any tag delivered in your preferred vector for JAKMIP1
	GenScript Custom Assay Services for JAKMIP1		GenScript Custom Superior Antibodies Services for JAKMIP1
	GenScript Custom overexpressing Cell Line Services for JAKMIP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in JAKMIP1 promoter
	Search Chromatin IP Primers for JAKMIP1
	RT² qPCR Primer Assay in human, mouse / rat JAKMIP1
	GNC Network for JAKMIP1
	SABiosciences Custom PCR Arrays for JAKMIP1

Search Tocris compounds for JAKMIP1 (JKIP1)

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	JAKMIP1 antibodies
	JAKMIP1 lysates

	Antibodies for JAKMIP1
	See all of Abcam's Antibodies, Kits and Proteins for JAKMIP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for JAKMIP1
	Antibodies for JAKMIP1
	ELISAs for JAKMIP1
	CLIAs for JAKMIP1

Search LifeMap BioReagents cell lines for JAKMIP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

	SwitchGear 3'UTR luciferase reporter plasmids for JAKMIP1
	SwitchGear Promoter luciferase reporter plasmids for JAKMIP1

ThermoFisher Antibodies for JAKMIP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1

	inGenious Targeting Laboratory - Custom generated mouse model solutions for JAKMIP1
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for JAKMIP1

Customized:

	lentivirus for stable overexpression of JAKMIP1
	lentivirus expression plasmids for stable overexpression of JAKMIP1
	adenovirus for overexpression of JAKMIP1

LSBio Antibodies in human, mouse, rat for JAKMIP1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes JAKMIP1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

JAKMIP1 Gene

Janus Kinase And Microtubule Interacting Protein 1

Aliases
for JAKMIP1 gene

Summaries
for JAKMIP1 gene

Genomic Views
for JAKMIP1 gene

Proteins
for JAKMIP1 gene

Protein Domains /
Families
for JAKMIP1 gene

Function
for JAKMIP1 gene

Pathways & Interactions
for JAKMIP1 gene

Drugs & Compounds
for JAKMIP1 gene

Transcripts
for JAKMIP1 gene

Expression
for JAKMIP1 gene

Orthologs
for JAKMIP1 gene

Paralogs
for JAKMIP1 gene

Genomic Variants
for JAKMIP1 gene

Disorders / Diseases
for JAKMIP1 gene

Publications
for JAKMIP1 gene

External Searches for JAKMIP1 gene

Genome Databases showing JAKMIP1 gene

Other Databases showing JAKMIP1 gene

Specialized Databases showing JAKMIP1 gene

Intellectual Property
for JAKMIP1 gene

Products
for JAKMIP1 gene

View Random Gene

Advanced Search

Export list of displayed genes

JAKMIP1 Gene

Janus Kinase And Microtubule Interacting Protein 1

Aliasesfor JAKMIP1 gene

Summariesfor JAKMIP1 gene

Genomic Viewsfor JAKMIP1 gene

Proteinsfor JAKMIP1 gene

Protein Domains /Familiesfor JAKMIP1 gene

Functionfor JAKMIP1 gene

Pathways & Interactionsfor JAKMIP1 gene

Drugs & Compoundsfor JAKMIP1 gene

Transcriptsfor JAKMIP1 gene

Expression for JAKMIP1 gene

Orthologsfor JAKMIP1 gene

Paralogsfor JAKMIP1 gene

Genomic Variantsfor JAKMIP1 gene

Disorders / Diseasesfor JAKMIP1 gene

Publicationsfor JAKMIP1 gene

External Searches for JAKMIP1 gene

Genome Databases showing JAKMIP1 gene

Other Databases showing JAKMIP1 gene

Specialized Databases showing JAKMIP1 gene

Intellectual Propertyfor JAKMIP1 gene

Productsfor JAKMIP1 gene

View Random Gene

Aliases
for JAKMIP1 gene

Summaries
for JAKMIP1 gene

Genomic Views
for JAKMIP1 gene

Proteins
for JAKMIP1 gene

Protein Domains /
Families
for JAKMIP1 gene

Function
for JAKMIP1 gene

Pathways & Interactions
for JAKMIP1 gene

Drugs & Compounds
for JAKMIP1 gene

Transcripts
for JAKMIP1 gene

Expression
for JAKMIP1 gene

Orthologs
for JAKMIP1 gene

Paralogs
for JAKMIP1 gene

Genomic Variants
for JAKMIP1 gene

Disorders / Diseases
for JAKMIP1 gene

Publications
for JAKMIP1 gene

Intellectual Property
for JAKMIP1 gene

Products
for JAKMIP1 gene