Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

JAKMIP1 Gene

protein-coding GIFtS: 52
GCID: GC04M005962

Janus Kinase And Microtubule Interacting Protein 1

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Janus Kinase And Microtubule Interacting Protein 1¹ ²		Jak And Microtubule Interacting Protein 1²
JAMIP1² ³ ⁵		Janus Kinase And Microtubule-Interacting Protein 1²
MARLIN1² ³ ⁵		marlin-1²
Multiple Alpha-Helices And RNA-Linker Protein 1² ³		Multiple Coiled-Coil GABABR1-Binding Protein²
GABA-B Receptor-Binding Protein² ³		GABABRBP³
Gababrbp²		Marlin-1³

External Ids:	HGNC: 26460¹	Entrez Gene: 152789²	Ensembl: ENSG00000152969⁷	OMIM: 611195⁵	UniProtKB: Q96N16³

Export aliases for JAKMIP1 gene to outside databases

Previous GC identifer: GC04M006106

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for JAKMIP1 Gene:

JAKMIP1 (janus kinase and microtubule interacting protein 1) is a protein-coding gene. Diseases associated with JAKMIP1 include crohn's disease, and breast and colorectal cancer. GO annotations related to this gene include kinase binding and RNA binding. An important paralog of this gene is JAKMIP3.

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B

receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000004.12 NC_018915.2 NT_006051.19

Regulatory elements:

Regulatory transcription factor binding sites in the JAKMIP1 gene promoter:
AhR Spz1 AML1a p300 AP-4 Arnt AREB6 NF-Y CBF(2) ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JAKMIP1 promoter sequence

Search Chromatin IP Primers for JAKMIP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAKMIP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1

JAKMIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAKMIP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M005962: view genomic region (about GC identifiers)

Start:	6,027,926 bp from pter	End:	6,202,318 bp from pter
Size:	174,393 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 (See protein sequence)

Recommended Name: Janus kinase and microtubule-interacting protein 1

Size: 626 amino acids; 73209 Da

Subunit: Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2

Caution: Was originally (PubMed:14718537) thought to bind single-stranded RNA molecules and regulate GABA-B

receptor expression

Sequence caution: Sequence=BAC05325.1; Type=Erroneous termination; Positions=285; Note=Translated as Arg;

Sequence=BAC05325.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: A6H2J2 A6H2J3 A6H2J4 A6H2J5 A8MTK6 B8ZZR7 D3DVT0 Q86Y69 Q8N7G3

Alternative splicing: 6 isoforms: Q96N16-1 Q96N16-2 Q96N16-3 Q96N16-4 Q96N16-5 Q96N16-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for JAKMIP1: NX_Q96N16

Explore proteomics data for JAKMIP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See JAKMIP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001092903.1 NP_653321.1

ENSEMBL proteins:

ENSP00000386711 ENSP00000387042 ENSP00000422004 ENSP00000282924 ENSP00000386925

ENSP00000386745

JAKMIP1 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for JAKMIP1 OriGene Custom MassSpec OriGene Custom Protein Services for JAKMIP1
	GenScript Custom Purified and Recombinant Proteins Services for JAKMIP1
	Novus Biologicals JAKMIP1 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for JAKMIP1

JAKMIP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for JAKMIP1 OriGene Custom Antibody Services for JAKMIP1
	Novus Biologicals JAKMIP1 Antibodies
	Abcam antibodies for JAKMIP1
	Cloud-Clone Corp. Antibodies for JAKMIP1
	ThermoFisher Antibodies for JAKMIP1
	LSBio Antibodies in human, mouse, rat for JAKMIP1

JAKMIP1 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for JAKMIP1
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for JAKMIP1
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for JAKMIP1 Cloud-Clone Corp. CLIAs for JAKMIP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR024836 JAKMIP

Graphical View of Domain Structure for InterPro Entry Q96N16

ProtoNet protein and cluster: Q96N16

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Similarity: Belongs to the JAKMIP family

JAKMIP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: JKIP1_HUMAN, Q96N16

Function: Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B

receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	14718537
GO:0005515	protein binding	IPI	17500595
GO:0008017	microtubule binding	IEA	--
GO:0019894	kinesin binding	IEA	--
GO:0019900	kinase binding	IEA	--

JAKMIP1 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAKMIP1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JAKMIP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JAKMIP1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JAKMIP1

miRNA Products:		miRTarBase miRNAs that target JAKMIP1: hsa-mir-335-5p (MIRT018896)

		Block miRNA regulation of human, mouse, rat JAKMIP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate JAKMIP1 (see all 32):
		hsa-miR-3910 hsa-miR-34b* hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-449a hsa-miR-124 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: JAKMIP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for JAKMIP1
		Predesigned siRNA for gene silencing in human, mouse, rat JAKMIP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for JAKMIP1

Clone Products:		OriGene clones in human, mouse for JAKMIP1 (see all 10) OriGene ORF clones in mouse, rat for JAKMIP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): JAKMIP1 (NM_001099433)
		Sino Biological Human cDNA Clone for JAKMIP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAKMIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for JAKMIP1
		Browse ESI BIO Cell Lines and PureStem Progenitors for JAKMIP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

JKIP1_HUMAN, Q96N16: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the

microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in

granules. Localizes to the tail and to a lower extent to the head of sperm cells

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
nucleus	3
cytosol	2
peroxisome	2
golgi apparatus	1
mitochondrion	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0019898	extrinsic component of membrane	IDA	14718537
GO:0030529	ribonucleoprotein complex	IDA	14718537

JAKMIP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for JAKMIP1 About

See pathways by source

SuperPath

Contained pathways About

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

1 BioSystems Pathway for JAKMIP1

Integrated Breast Cancer Pathway

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for JAKMIP1
Interactions:

GeneGlobe Interaction Network for JAKMIP1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

Selected Interacting proteins for JAKMIP1 (Q96N16³ ENSP00000386711⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000232632	Q9UBS5³, ENSP00000388035⁴	I2D: score=2 STRING: ENSP00000388035
GABBR1	Q9UBS5³, ENSP00000366233⁴	I2D: score=2 STRING: ENSP00000366233
ENSG00000206466	Q9UBS5³	I2D: score=2
ENSG00000206511	Q9UBS5³	I2D: score=2
ENSG00000232569	Q9UBS5³	I2D: score=2

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015031	protein transport	IEA	--
GO:0050890	cognition	IMP	17519220

JAKMIP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for JAKMIP1 (JKIP1)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for JAKMIP1 gene (2 alternative transcripts):

NM_001099433.1 NM_144720.3

Unigene Cluster for JAKMIP1:

Janus kinase and microtubule interacting protein 1

Hs.479066 [show with all ESTs]

Unigene Representative Sequence: NM_001099433

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409021(uc010idb.1 uc010idd.1) ENST00000409371(uc010idc.1)

ENST00000473053(uc010ide.3) ENST00000282924(uc003giv.4) ENST00000409831(uc003giu.4 uc011bwc.2)

ENST00000410077 ENST00000457227

miRNA Products:		Block miRNA regulation of human, mouse, rat JAKMIP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate JAKMIP1 (see all 32):
		hsa-miR-3910 hsa-miR-34b* hsa-miR-25 hsa-miR-301a hsa-miR-519a hsa-miR-449a hsa-miR-124 hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: JAKMIP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for JAKMIP1
		Predesigned siRNA for gene silencing in human, mouse, rat JAKMIP1

Clone Products:		OriGene clones in human, mouse for JAKMIP1 (see all 10) OriGene ORF clones in mouse, rat for JAKMIP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): JAKMIP1 (NM_001099433)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAKMIP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1

Primer Products:		OriGene qPCR primer pairs and template standards for JAKMIP1 OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat JAKMIP1
		QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1
		QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1

Additional mRNA sequence:

AK056126.1 AK098536.1 AK124718.1 AK294356.1 AK295339.1 AK307983.1 AM412307.1 AM412308.1

AM412309.1 AM412310.1 AY382340.1 BC026343.1 BC047075.1

6 DOTS entries:

DT.445810 DT.92020668 DT.101975859 DT.100020164 DT.91977808 DT.95360916

Selected AceView cDNA sequences (see all 31):

BQ639074 AK098536 BU617552 Z44031 NM_144720 AL525796 AW954559 AK056126

AY382340 BM675261 BP429586 BM689820 BM685608 AL525757 BG705618 BI668982

AK124718 BC047075 R42780 AW157571 BC026343 BM695429 BM714077 H08055

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15
SP1:			-		-
SP2:					-
SP3:							-		-																-

ECgene alternative splicing isoforms for JAKMIP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

JAKMIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

JAKMIP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Eye (Sensory Organs)
Retina

Endothelium (Cardiovascular System)
Mature Endothelial Cells Blood Brain Barrier

Brain (Nervous System)
Mature Endothelial Cells Blood Brain Barrier

Ovary (Reproductive System)

JAKMIP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

JAKMIP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.479066

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16

Tissue specificity: Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2,

isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected

in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine

Custom PCR Arrays for JAKMIP1

Primer Products:		OriGene qPCR primer pairs and template standards for JAKMIP1 OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat JAKMIP1
		QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1
		QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for JAKMIP1 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Jakmip1^{1 , 5}	janus kinase and microtubule interacting protein 1^{1, 5}	87.49(n)¹ 95.21(a)¹		5 (19.66 cM)⁵ 76071¹ NM_178394.4¹ NP_848481.2¹ 37028335⁵
chicken (Gallus gallus)	Aves	JAKMIP1¹	janus kinase and microtubule interacting protein 1	76.73(n) 84.96(a)		422854 XM_004936175.1 XP_004936232.1
lizard (Anolis carolinensis)	Reptilia	--	--	65(a)	many ↔ many	5(80450342-80496717)
tropical clawed frog (Xenopus tropicalis)	Amphibia	BX730452.1²	--	74.38(n)		BX730452.1
zebrafish (Danio rerio)	Actinopterygii	jakmip3¹	Janus kinase and microtubule interacting protein 3	67.33(n) 68.44(a)		555987 XM_678676.5 XP_683768.4

ENSEMBL Gene Tree for JAKMIP1 (if available)
TreeFam Gene Tree for JAKMIP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for JAKMIP1 gene

JAKMIP3² JAKMIP2²

2 SIMAP similar genes for JAKMIP1 using alignment to 3 protein entries: JKIP1_HUMAN (see all proteins):

JAKMIP3 JAKMIP2

JAKMIP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_039472⁴		A colorectal cancer sample⁴	--	see VAR_039472	2	A V	mis⁴		0	--	--	--	--
rs115436213^1,2	C,F	--	6027436(+)	`CACAGG/TAGTCA`	1	--	ds500¹		1		WA	118
rs9291109^1,2	C,F,H	--	6027465(+)	`GGGTGA/TGACGG`	1	--	ds500¹		13		NA WA CSA	260
rs73196065^1,2	C	--	6027468(+)	`TGTGAC/TGGGGA`	1	--	ds500¹		0	--	--	--	--
rs142255197^1,2		--	6027485(+)	`TGAGTA/GGCTTC`	1	--	ds500¹		0	--	--	--	--
rs151283453^1,2	C	--	6027580(+)	`CCCTCA/GGCCCT`	1	--	ds500¹		0	--	--	--	--
rs139294764^1,2		--	6027586(+)	`GCCCTA/GGAAGC`	1	--	ds500¹		0	--	--	--	--
rs73196066^1,2	C	--	6027646(+)	`GAGCAC/ACAGGG`	1	--	ds500¹		3		NA WA	240
rs189791764^1,2		--	6027696(+)	`AGTCCC/TCCTTT`	1	--	ds500¹		0	--	--	--	--
rs181846718^1,2		--	6027744(+)	`TGAGCA/GTCCCT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for JAKMIP1 (6027926 - 6202318 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for JAKMIP1 (see all 27): About this table

Variant ID	Type	Subtype	PubMed ID
esv2726988	CNV	Deletion	23290073
esv2324557	CNV	Deletion	18987734
esv2726986	CNV	Deletion	23290073
esv2726985	CNV	Deletion	23290073
esv1003999	CNV	Deletion	20482838
esv998642	CNV	Deletion	20482838
esv2726990	CNV	Deletion	23290073
dgv919e199	CNV	Deletion	23128226
esv2675636	CNV	Deletion	23128226
esv2213984	CNV	Deletion	18987734

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing JAKMIP1

DNA2.0 Custom Variant and Variant Library Synthesis for JAKMIP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 611195 OMIM disorders: --

9 diseases for JAKMIP1:
About MalaCards

crohn's disease breast and colorectal cancer tonsillitis retinitis

colorectal cancer breast cancer endotheliitis prostatitis

neuronitis

JAKMIP1 for disorders About GeneDecksing

Genetic Association Database (GAD): JAKMIP1
Human Genome Epidemiology (HuGE) Navigator: JAKMIP1 (2 documents)

Export disorders for JAKMIP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for JAKMIP1 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with JAKMIP1)

Utopia: connect your pdf to the dynamic
world of online information

Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531)^{1, 2, 9} Steindler C....Pellegrini S. (J. Biol. Chem. 2004)
Identification and expression analysis of novel Jakmip1 transcripts. (PubMed id 17761393)^{1, 2, 9} Costa V....Ciccodicola A. (Gene 2007)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. (PubMed id 18941173)^{1, 3} Libri V....Pellegrini S. (J. Immunol. 2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Marlin-1, a novel RNA-binding protein associates with GABA receptors. (PubMed id 14718537)^{1, 2} Couve A.... Moss S.J. (J. Biol. Chem. 2004)
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)¹ Lauc G....Rudan I. (PLoS Genet. 2013)
Overexpression of JAKMIP1 associates with Wnt/I^-catenin pathway activation and promotes cancer cell proliferation in vitro. (PubMed id 23481296)¹ Okai I....Shao S. (amp 2013)
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)¹ Turner S.T....Boerwinkle E. (Hypertension 2012)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (Sci. Signal. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 152789	HGNC: 26460	AceView: MARLIN1	Ensembl:ENSG00000152969	euGenes: HUgn152789
ECgene: JAKMIP1	H-InvDB: JAKMIP1

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for JAKMIP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for JAKMIP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for JAKMIP1 gene:
Search GeneIP for patents involving JAKMIP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for JAKMIP1		OriGene RNAi products in human, mouse, rat for JAKMIP1
	OriGene qPCR primer pairs and template standards for JAKMIP1		OriGene Protein Over-expression Lysate for JAKMIP1
	OriGene Custom Mass Spec		OriGene clones in human, mouse for JAKMIP1
	OriGene qSTAR qPCR primer pairs in human, mouse for JAKMIP1		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for JAKMIP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for JAKMIP1		OriGene Custom Protein Services for JAKMIP1

	Block miRNA regulation of human, mouse, rat JAKMIP1 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing JAKMIP1
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAKMIP1		Predesigned siRNA for gene silencing in human, mouse, rat JAKMIP1
	QuantiFast Probe-based Assays in human, mouse, rat JAKMIP1		QuantiTect SYBR Green Assays in human, mouse, rat JAKMIP1
	Custom PCR Arrays for JAKMIP1		Search Chromatin IP Primers for JAKMIP1
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat JAKMIP1		GeneGlobe Interaction Network for JAKMIP1
	Regulatory tfbs in JAKMIP1 promoter

	GenScript Custom Purified and Recombinant Proteins Services for JAKMIP1		GenScript cDNA clones with any tag delivered in your preferred vector for JAKMIP1
	GenScript Custom Assay Services for JAKMIP1		GenScript Custom overexpressing Cell Line Services for JAKMIP1
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for JAKMIP1 (JKIP1)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for JAKMIP1
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	JAKMIP1 antibodies
	JAKMIP1 lysates

	Antibodies for JAKMIP1
	See all of Abcam's Antibodies, Kits and Proteins for JAKMIP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for JAKMIP1
	Antibodies for JAKMIP1
	ELISAs for JAKMIP1
	CLIAs for JAKMIP1

Browse ESI BIO Cell Lines and PureStem Progenitors for JAKMIP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAKMIP1

	SwitchGear 3'UTR luciferase reporter plasmids for JAKMIP1
	SwitchGear Promoter luciferase reporter plasmids for JAKMIP1

ThermoFisher Antibodies for JAKMIP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAKMIP1

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAKMIP1
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JAKMIP1

LSBio Antibodies in human, mouse, rat for JAKMIP1

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes JAKMIP1 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

JAKMIP1 Gene

Janus Kinase And Microtubule Interacting Protein 1

Aliases
for JAKMIP1 gene

Summaries
for JAKMIP1 gene

Genomic Views
for JAKMIP1 gene

Proteins
for JAKMIP1 gene

JAKMIP1 Human Recombinant Protein Products:

JAKMIP1 Antibody Products:

JAKMIP1 Assay Products:

Domains /
Families
for JAKMIP1 gene

Function
for JAKMIP1 gene

Localization
for JAKMIP1 gene

Pathways & Interactions
for JAKMIP1 gene

Drugs & Compounds
for JAKMIP1 gene

Transcripts
for JAKMIP1 gene

Expression
for JAKMIP1 gene

Orthologs
for JAKMIP1 gene

Paralogs
for JAKMIP1 gene

Genomic Variants
for JAKMIP1 gene

Disorders / Diseases
for JAKMIP1 gene

Publications
for JAKMIP1 gene

External Searches for JAKMIP1 gene

Genome Databases showing JAKMIP1 gene

Other Databases showing JAKMIP1 gene

Specialized Databases showing JAKMIP1 gene

Intellectual Property
for JAKMIP1 gene

Products
for JAKMIP1 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

JAKMIP1 Gene

Janus Kinase And Microtubule Interacting Protein 1

Aliasesfor JAKMIP1 gene

Summariesfor JAKMIP1 gene

Genomic Viewsfor JAKMIP1 gene

Proteinsfor JAKMIP1 gene

JAKMIP1 Human Recombinant Protein Products:

JAKMIP1 Antibody Products:

JAKMIP1 Assay Products:

Domains /Familiesfor JAKMIP1 gene

Functionfor JAKMIP1 gene

Localizationfor JAKMIP1 gene

Pathways & Interactionsfor JAKMIP1 gene

Drugs & Compoundsfor JAKMIP1 gene

Transcriptsfor JAKMIP1 gene

Expression for JAKMIP1 gene

Orthologsfor JAKMIP1 gene

Paralogsfor JAKMIP1 gene

Genomic Variantsfor JAKMIP1 gene

Disorders / Diseasesfor JAKMIP1 gene

Publicationsfor JAKMIP1 gene

External Searches for JAKMIP1 gene

Genome Databases showing JAKMIP1 gene

Other Databases showing JAKMIP1 gene

Specialized Databases showing JAKMIP1 gene

Intellectual Propertyfor JAKMIP1 gene

Productsfor JAKMIP1 gene

View Random Gene

Aliases
for JAKMIP1 gene

Summaries
for JAKMIP1 gene

Genomic Views
for JAKMIP1 gene

Proteins
for JAKMIP1 gene

Domains /
Families
for JAKMIP1 gene

Function
for JAKMIP1 gene

Localization
for JAKMIP1 gene

Pathways & Interactions
for JAKMIP1 gene

Drugs & Compounds
for JAKMIP1 gene

Transcripts
for JAKMIP1 gene

Expression
for JAKMIP1 gene

Orthologs
for JAKMIP1 gene

Paralogs
for JAKMIP1 gene

Genomic Variants
for JAKMIP1 gene

Disorders / Diseases
for JAKMIP1 gene

Publications
for JAKMIP1 gene

Intellectual Property
for JAKMIP1 gene

Products
for JAKMIP1 gene