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Aliases & Descriptions for JAKMIP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ31564 2 GABABRBP 3 Gababrbp 1 , 2 JAMIP1 1 , 2 , 3 MARLIN1 1 , 2 , 3 Marlin-1 3
Descriptions GABA-B receptor-binding protein 3 Jak and microtubule interacting protein 1 2 Janus kinase and microtubule interacting protein 1 2 Multiple alpha-helices and RNA-linker protein 1 3 multiple coiled-coil GABABR1-binding protein 2
Search outside databases for aliases for JAKMIP1 gene
Summaries for JAKMIP1 (According to Entrez Gene ,
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UniProtKB/Swiss-Prot ,
and/or
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UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 Function : Associates with microtubules and may play a role in the microtubule-dependent transportof the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeletonrearrangements
Genomic Location for JAKMIP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the JAKMIP1 gene Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1 JAKMIP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M006106:
(about GC identifiers )
Start:
6,078,827 bp from pter
End:
6,253,219 bp from pter
Size:
174,393 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_006051.17 Proteins for JAKMIP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 (See
protein sequence )Recommended Name: Janus kinase and microtubule-interacting protein 1 Size : 626 amino acids; 73209 Da
Subunit : Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2
Subcellular location : Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites ofhippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extentto the head of sperm cells
Caution : Was originally (PubMed:14718537) thought to bind single-stranded RNA molecules andregulate GABA-B receptor expression
Sequence caution : Sequence=BAC05325.1; Type=Erroneous termination; Positions=285; Note=Translatedas Arg; Sequence=BAC05325.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions : A6H2J2 A6H2J3 A6H2J4 A6H2J5 A8MTK6 Q86Y69 Q8N7G3Alternative splicing : 6 isoforms : Q96N16-1 Q96N16-2 Q96N16-3 Q96N16-4 Q96N16-5 Q96N16-6
Post-translational modifications:
Phosphorylated1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001092903.1 NP_653321.1 ENSEMBL proteins: ENSP00000386745 ENSP00000386925 ENSP00000282924 ENSP00000387042 ENSP00000386711 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: JAKMIP1 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for JAKMIP1: Assays for JAKMIP1:
Protein
Domains/ Families for JAKMIP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q96N16
UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 Similarity : Belongs to the JAKMIP family
Gene Function for JAKMIP1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001099433 Applied Biosystems Silencer ® siRNAs for JAKMIP1 Sigma-Aldrich siRNA for JAKMIP1 Sigma-Aldrich shRNA for JAKMIP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001099433 UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 Function : Associates with microtubules and may play a role in the microtubule-dependent transportof the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeletonrearrangements
2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for JAKMIP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for JAKMIP1 --1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0015031 protein transport
IEA --
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Drugs & Compounds for JAKMIP1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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PharmGKB )
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Browse Tocris compounds for JAKMIP1
Transcripts for JAKMIP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001099433 Sigma-Aldrich siRNA for JAKMIP1 Sigma-Aldrich shRNA for JAKMIP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001099433 NM_144720
REFSEQ mRNAs for JAKMIP1 gene (2 alternative transcripts): NM_001099433.1 NM_144720.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001099433 NM_144720
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001099433  
Additional cDNA sequence: AK056126.1 AK098536.1 AK124718.1 AK294356.1 AK295339.1 AK307983.1 AM412307.1 AM412308.1 AM412309.1 AM412310.1 AY382340.1 BC026343.1 BC047075.1
6 DOTS entries : DT.445810 DT.101975859 DT.92020668 DT.100020164 DT.91977808 DT.95360916
24/31 AceView cDNA sequences (see all 31
):Z44031 AW954559 AK056126 AY382340 BU617552 NM_144720 BQ639074 AL525796 BM675261 AK098536 AW157571 BC026343 BI668982 BM685608 AK124718 BM695429 BG705618 BC047075 BM689820 AL525757 R42780 BP429586 BM714077 BX333963
highest scoring ESTs for JAKMIP1 :AK056126 AW163447 BC026343 BC047075 BG705618 BI668982 AK124718 AL525796 AW157571 AW954559
Unigene Cluster for JAKMIP1: Janus kinase and microtubule interacting protein 1 Hs.479066 [show with all ESTs ] Unigene Representative Sequence: NM_001099433 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP1 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 SP1 :   -   -                             SP2 :     -                             SP3 :       -   -                 -        
About this scheme ECgene alternative splicing isoforms for JAKMIP1 5 Ensembl transcripts including schematic representations : ENST00000410077
ENST00000409831
ENST00000282924
ENST00000409371
ENST00000409021
Expression for JAKMIP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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JAKMIP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for JAKMIP1 1 / 2 / 3
3 probe-sets matching JAKMIP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.479066 UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 Tissue specificity : Predominantly expressed in neural tissues and lymphoid cells (at proteinlevel). Isoforms 2, 3 and 4 are specifically expressed in brain and retina while isoform 1 andisoform 5 are also detected in liver, lung and skelelal muscle. Also detected in testis and to alower extent spleen and intestine
Orthologs for JAKMIP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for JAKMIP1 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for JAKMIP1 ENSEMBL Gene Tree for JAKMIP1 Paralogs for JAKMIP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for JAKMIP1 gene JAKMIP3 2 JAKMIP2 2
SNPs/Variants for JAKMIP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for JAKMIP1 (up to first 250kb)
Disorders & Mutations for JAKMIP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611195 Human Genome Epidemiology Navigator: JAKMIP1 (1 document)
Medical News for JAKMIP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for JAKMIP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for JAKMIP1 gene (see all 14
): Jamip1 (marlin-1) defines a family of proteins interacting with Janus kinases and microtubules. (PubMed id 15277531) 1, 3, 4 Steindler C....Pellegrini S. (2004) Identification and expression analysis of novel Jakmip1 transcripts. (PubMed id 17761393) 1, 3, 4 Costa V....Ciccodicola A. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Marlin-1, a novel RNA-binding protein associates with GABA receptors. (PubMed id 14718537) 3, 4 Couve A.... Moss S.J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 2, 3 Strausberg R.L....Marra M.A. (2002) Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. (PubMed id 18941173) 3 Libri V....Pellegrini S. (2008) Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins. (PubMed id 17572408) 3 Cruz-Garcia D....Malagon M.M. (2007) Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. (PubMed id 17532644) 4 Vidal R.L....Couve A. (2007) Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. (PubMed id 17804789) 3 Raelson J.V....Schreiber S. (2007) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 4 Sjoeblom T.... Velculescu V.E. (2006)
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Genome Databases showing JAKMIP1
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing JAKMIP1
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Specialized Databases showing JAKMIP1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for JAKMIP1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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