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JAKMIP1 Gene

protein-coding   GIFtS: 43

GC04M006106
Janus kinase and microtubule interacting protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ31564 2
GABABRBP 3
Gababrbp 1, 2
JAMIP1 1, 2, 3
MARLIN1 1, 2, 3
Marlin-1 3
Descriptions
GABA-B receptor-binding protein 3
Jak and microtubule interacting protein 1 2
Janus kinase and microtubule interacting protein 1 2
Multiple alpha-helices and RNA-linker protein 1 3
multiple coiled-coil GABABR1-binding protein 2
External Ids
HGNC: 264601
Entrez Gene: 1527892
UniProtKB: Q96N163
Ensembl: ENSG000001529697
Search outside databases for aliases for JAKMIP1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16
Function: Associates with microtubules and may play a role in the microtubule-dependent transport
of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton
rearrangements

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the JAKMIP1 gene  

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

JAKMIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M006106:     (about GC identifiers)

Start:
6,078,827 bp from pter
End:
6,253,219 bp from pter
Size:
174,393 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000004.10  NT_006051.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16 (See protein sequence)
Recommended Name: Janus kinase and microtubule-interacting protein 1  
Size: 626 amino acids; 73209 Da
Subunit: Homodimer. Forms a complex with GABBR1 and KIF5B/kinesin-1. Interacts with JAK1 and TYK2
Subcellular location: Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of
hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent
to the head of sperm cells
Caution: Was originally (PubMed:14718537) thought to bind single-stranded RNA molecules and
regulate GABA-B receptor expression
Sequence caution: Sequence=BAC05325.1; Type=Erroneous termination; Positions=285; Note=Translated
as Arg; Sequence=BAC05325.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: A6H2J2 A6H2J3 A6H2J4 A6H2J5 A8MTK6 Q86Y69 Q8N7G3
Alternative splicing: 6 isoforms:  Q96N16-1   Q96N16-2   Q96N16-3   Q96N16-4   Q96N16-5   Q96N16-6   

Post-translational modifications:

  • Phosphorylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001092903.1  NP_653321.1  


    ENSEMBL proteins: 
    ENSP00000386745 ENSP00000386925 ENSP00000282924 ENSP00000387042 ENSP00000386711 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: JAKMIP1 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000300 peripheral to membrane of membrane fraction IDA14718537
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton IEA--
    GO:0005874 microtubule IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for JAKMIP1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for JAKMIP1
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for JAKMIP1

    Assays for JAKMIP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96N16

    UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16
    Similarity: Belongs to the JAKMIP family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JAKMIP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099433

                  Applied Biosystems Silencer® siRNAs for JAKMIP1

                  Sigma-Aldrich siRNA for JAKMIP1  
                         Sigma-Aldrich shRNA for JAKMIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for JAKMIP1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099433
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099433
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001099433 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001099433

    UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16
    Function: Associates with microtubules and may play a role in the microtubule-dependent transport
    of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton
    rearrangements

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding IDA14718537
    GO:0050811 GABA receptor binding IDA14718537
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  JAKMIP1 

      --

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031 protein transport IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for JAKMIP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (JAKMIP1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099433

                  Sigma-Aldrich siRNA for JAKMIP1  
                         Sigma-Aldrich shRNA for JAKMIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001099433  NM_144720  

    REFSEQ mRNAs for JAKMIP1 gene (2 alternative transcripts): 

    NM_001099433.1   NM_144720.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001099433  NM_144720  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099433
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099433
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001099433 

    Additional cDNA sequence: 

    AK056126.1 AK098536.1 AK124718.1 AK294356.1 AK295339.1 AK307983.1 AM412307.1 AM412308.1 
    AM412309.1 AM412310.1 AY382340.1 BC026343.1 BC047075.1 

    6 DOTS entries:

    DT.445810  DT.101975859  DT.92020668  DT.100020164  DT.91977808  DT.95360916 

    24/31 AceView cDNA sequences (see all 31 ):

    Z44031 AW954559 AK056126 AY382340 BU617552 NM_144720 BQ639074 AL525796 
    BM675261 AK098536 AW157571 BC026343 BI668982 BM685608 AK124718 BM695429 
    BG705618 BC047075 BM689820 AL525757 R42780 BP429586 BM714077 BX333963 

    highest scoring ESTs for JAKMIP1:

    AK056126 AW163447 BC026343 BC047075 BG705618 BI668982 AK124718 AL525796 AW157571 AW954559 

    Unigene Cluster for JAKMIP1:

    Janus kinase and microtubule interacting protein 1
    Hs.479066  [show with all ESTs]
    Unigene Representative Sequence: NM_001099433


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for JAKMIP1

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:        -     -                                                                                 
    SP2:              -                                                                                 
    SP3:                    -     -                                               -                     

    About this scheme

    ECgene alternative splicing isoforms for JAKMIP1

    5 Ensembl transcripts including schematic representations:
    ENST00000410077  ENST00000409831  ENST00000282924  ENST00000409371  ENST00000409021  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    JAKMIP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for JAKMIP1

    1 / 2 / 3

    3 probe-sets matching JAKMIP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    42262_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 T03800 0.60 1.00 0.82 1

    238600_at2, 3 U133-B 1 1.00 1.00 -- -- AW157571 0.60 1.00 0.82 1

    238600_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  JAKMIP1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.479066

    UniProtKB/Swiss-Prot: JKIP1_HUMAN, Q96N16
    Tissue specificity: Predominantly expressed in neural tissues and lymphoid cells (at protein
    level). Isoforms 2, 3 and 4 are specifically expressed in brain and retina while isoform 1 and
    isoform 5 are also detected in liver, lung and skelelal muscle. Also detected in testis and to a
    lower extent spleen and intestine

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for JAKMIP1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    JAKMIP11   -- janus kinase and microtubule interacting protein 1 91.34(n)
    96.91(a)
    488830  XM_545948.2  XP_545948.2 
    chimpanzee
    (Pan troglodytes)
    JAKMIP11   -- janus kinase and microtubule interacting protein 1 98.78(n)
    99.24(a)
    471130  XM_526512.2  XP_526512.2 
    cow
    (Bos taurus)
    JAKMIP11   -- janus kinase and microtubule interacting protein 1 92.35(n)
    96.72(a)
    540970  XM_613920.3  XP_613920.3 
    rat
    (Rattus norvegicus)
    Jakmip11   -- janus kinase and microtubule interacting protein 1 87.22(n)
    95.7(a)
    305434  NM_001033894.1  NP_001029066.1 
    mouse
    (Mus musculus)
    Jakmip11, 5 55
    janus kinase and microtubule interacting protein 11, 5 87.38(n)1
    95.04(a)1
    760711  NM_178394.31  NP_848481.11 
     AI8519145  AK0179775  (see all 11)
    About this table        Species with no ortholog for JAKMIP1

    ENSEMBL Gene Tree for JAKMIP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for JAKMIP1 gene
    JAKMIP32  JAKMIP22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1196 NCBI SNPs in JAKMIP1 are shown (see all 1196 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 329)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs168381221,2
    C,F,H6106059(+) CTGGAT/CAAAAG 2 -- int1 ng5111Minor allele frequency- C:0.03NA EU EA WA 980
    --
    rs92911091,2
    C6078366(+) GGGTGA/TGACGG 1 -- ng510--------
    rs8854201,2
    A,C,F,H,O6236717(+) TGAGAA/CTAAAC 2 -- int121Minor allele frequency- C:0.42NA EA EU WA 1930
    --
    rs7658311,2
    A,C,F,H,O6084558(+) AACTGA/GTAATT 1 -- int19Minor allele frequency- G:0.38MN EU EA WA 1022
    rs18777621,2
    A,C,F,H,O6241952(-) GATGAG/AATTTG 2 -- int113Minor allele frequency- A:0.19EA EU WA NA 1160
    rs64464461,2
    A,C,F,H6098658(+) GGTGCT/CCACCC 1 -- int14Minor allele frequency- C:0.26EU EA WA 412
    rs42866161,2
    A,C,F,H6194858(+) ACAGAC/TTTAGA 2 -- int14Minor allele frequency- T:0.18EU EA WA 418
    rs76667921,2
    A,C,F,H6210855(+) AACTTT/CGCCCT 2 -- int18Minor allele frequency- C:0.12EU EA WA 818
    rs131279671,2
    A,C,F,H6156934(+) caaccG/Ataact 2 -- int14Minor allele frequency- A:0.08EU EA WA 402
    rs23585771,2
    A,C,F,O6215066(-) GCTCAC/TGTGGC 2 -- int13Minor allele frequency- T:0.37NA 142
    About this table

    HapMap Linkage Disequilibrium images for JAKMIP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611195

    Human Genome Epidemiology Navigator: JAKMIP1 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/14 PubMed articles for JAKMIP1 gene (see all 14 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 152789 HGNC: 26460 AceView: MARLIN1 Ensembl:ENSG00000152969 euGenes: HUgn152789
    ECgene: JAKMIP1 H-InvDB: JAKMIP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for JAKMIP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for JAKMIP1 Antibodies for JAKMIP1
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     Lentivirus-delivered shRNAs for JAKMIP1 Browse small molecules at Sigma-Aldrich
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