Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



JAK2 Gene

protein-coding   GIFtS: 74
GCID: GC09P004985

Janus Kinase 2

  See JAK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Janus Kinase 21 2 3     JTK102
JAK-22 3     Janus Kinase 2 (A Protein Tyrosine Kinase)2
EC 2.7.10.23 8     Tyrosine-Protein Kinase JAK22
THCYT32 5     EC 2.7.108

External Ids:    HGNC: 61921   Entrez Gene: 37172   Ensembl: ENSG000000969687   OMIM: 1477965   UniProtKB: O606743   

Export aliases for JAK2 gene to outside databases

Previous GC identifers: GC09P005139 GC09P004966 GC09P004975 GC09P004940


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for JAK2 Gene:
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling
pathways. It has been found to be constituitively associated with the prolactin receptor and is required for
responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic
lethality associated with the absence of definitive erythropoiesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for JAK2 Gene:
JAK2 (Janus kinase 2) is a protein-coding gene. Diseases associated with JAK2 include jak2-related budd-chiari syndrome, and myelofibrosis. GO annotations related to this gene include protein kinase binding and protein kinase activity. An important paralog of this gene is SYK.

UniProtKB/Swiss-Prot: JAK2_HUMAN, O60674
Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development,
differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive
immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors
such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or
type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to
cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor,
creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are
recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the
nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during
erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor
(EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited,
phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes
the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2
mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B.
Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS
transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of
'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin

summary for JAK2 Gene:
JAKs (or Janus kinases) are a family of tyrosine kinases that associated with cytokine receptors. Upon
receptor activation JAKs phosphorylate the transcription factors known as STATs and initiate the JAK-STAT
signaling pathway. Four JAK family members have been identified (JAK1, JAK2, JAK3 and Tyk2), which share a
similar protein domain structure: a kinase domain, a regulatory pseudo -kinase domain, a SH2 domain and a
FERM domain. The FERM domain of JAK family members mediates the association of JAK with other enzymes and
cytokine receptors. The JAK Tyk2 associates with the IFN-1, IL-6, 10, 12, and 23 cytokine receptor families.
JAK1 mediates signals from IFN-alpha, beta, gamma and IL-2, 6 receptors. JAK2 transduces signals from the
single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors. JAK3 associates with the
IL-2 receptor gamma-chain.

Gene Wiki entry for JAK2 (Janus kinase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the JAK2 gene promoter:
         STAT5B   AP-1   ATF-2   Olf-1   STAT3   c-Jun   STAT5A   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidJAK2 promoter sequence
   Search Chromatin IP Primers for JAK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24

JAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAK2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P004985:  view genomic region     (about GC identifiers)

Start:
4,985,033 bp from pter      End:
5,128,183 bp from pter
Size:
143,151 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: JAK2_HUMAN, O60674 (See protein sequence)
Recommended Name: Tyrosine-protein kinase JAK2  
Size: 1132 amino acids; 130674 Da
Subunit: Interacts with EPOR, LYN, SIRPA, SH2B1 and TEC (By similarity). Interacts with IL23R, SKB1 and STAM2
Selected PDB 3D structures from and Proteopedia for JAK2 (see all 38):
2B7A (3D)        2W1I (3D)        2XA4 (3D)        3E62 (3D)        3E63 (3D)        3E64 (3D)    
Secondary accessions: O14636 O75297

Explore the universe of human proteins at neXtProt for JAK2: NX_O60674

Explore proteomics data for JAK2 at MOPED

Post-translational modifications: 

  • Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues,
    including phosphorylation on Tyr-813. Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase
    activity. Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for
    maximal kinase activity. Also phosphorylated by TEC (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for JAK2 (O60674) (see all 33)
     DVSIKQA  DAHHYLC  FEERHLK  NGRLPRP 


    See JAK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004963.1  
    ENSEMBL proteins: 
     ENSP00000371067   ENSP00000440387   ENSP00000443103  
    Reactome Protein details: O60674

    JAK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant JAK2 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for JAK2
    OriGene Purified Protein for JAK2
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for JAK2
    OriGene Custom Protein Services for JAK2
    GenScript Custom Purified and Recombinant Proteins Services for JAK2
    Novus Biologicals JAK2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for JAK2

     
    Search eBioscience for Proteins for JAK2 

    JAK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of JAK2
    R&D Systems Antibodies for JAK2
    Cell Signaling Technology (CST) Antibodies for JAK2 
    OriGene Antibodies for JAK2
    OriGene Custom Antibody Services for JAK2
    Novus Biologicals JAK2 Antibodies
    Abcam antibodies for JAK2
    Cloud-Clone Corp. Antibodies for JAK2
    ThermoFisher Antibodies for JAK2
    Search LSBio for Antibodies for JAK2

    JAK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for JAK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for JAK2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for JAK2
    Cloud-Clone Corp. CLIAs for JAK2
    Search eBioscience for ELISAs for JAK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: Janus kinase 2
    Janus kinase (JakA) family

    Selected InterPro protein domains (see all 12):
     IPR019748 FERM_central
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR020693 Tyr_kinase_non-rcpt_Jak2
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O60674

    ProtoNet protein and cluster: O60674

    2 Blocks protein domains:
    IPB008266 Tyrosine protein kinase
    IPB009127 Janus kinase family signature


    UniProtKB/Swiss-Prot: JAK2_HUMAN, O60674
    Domain: Possesses 2 protein kinase domains. The second one probably contains the catalytic domain, while the
    presence of slight differences suggest a different role for protein kinase 1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily
    Similarity: Contains 1 FERM domain
    Similarity: Contains 2 protein kinase domains
    Similarity: Contains 1 SH2 domain


    Find genes that share domains with JAK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: JAK2_HUMAN, O60674
    Function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development,
    differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive
    immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors
    such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or
    type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to
    cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor,
    creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are
    recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the
    nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during
    erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor
    (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited,
    phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes
    the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2
    mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B.
    Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS
    transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of
    'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Regulated by autophosphorylation, can both activate or decrease activity (By similarity). Heme
    regulates its activity by enhancing the phosphorylation on Tyr-1007 and Tyr-1008

         Genatlas biochemistry entry for JAK2:
    Janus tyrosine kinase 2,non receptor type,class III,murine FD-17 homolog,playing pivotal functions for signal
    transduction fromhematopoietic cytokine receptors,mediating the activation of STAT proteins,required in
    definitive erythropoiesis,involved in GH induced activation of the GH receptor. Also activated in leukemia or
    constitutively expressed in acute lymphoblastic leukemia with t(9;12) (p24;p13) and a chimeric fusion protein,5'
    - ETV6 -JAK2 - 3'.

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS9670957
    GO:0004713protein tyrosine kinase activity TAS--
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005102receptor binding IPI11201744
    GO:0005131growth hormone receptor binding ISS--
         
    Find genes that share ontologies with JAK2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for JAK2:
     Decreased substrate adherent c  Decreased telomerase activity  Increased cell death HMECs cel  Increased cell number in G1, s 
     Wnt reporter downregulated 

         13 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Jak2):
     cellular  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  normal 
     reproductive system  skeleton  tumorigenesis 

    Find genes that share phenotypes with JAK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for JAK2: Jak2tm1Kpf Jak2tm1Jni Jak2tm1.1Kuw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JAK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for JAK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for JAK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target JAK2:
    hsa-mir-335-5p (MIRT017973), hsa-mir-16-5p (MIRT051067), hsa-mir-375 (MIRT001749), hsa-mir-195-5p (MIRT044858), hsa-mir-135a-5p (MIRT000707)

    Block miRNA regulation of human, mouse, rat JAK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JAK2 (see all 18):
    hsa-miR-623 hsa-miR-607 hsa-miR-373* hsa-miR-204 hsa-miR-548x hsa-miR-3121-3p hsa-miR-375 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidJAK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for JAK2
    Predesigned siRNA for gene silencing in human, mouse, rat JAK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for JAK2

    Clone
    Products:
         
    OriGene clones in human, mouse for JAK2 (see all 6)
    OriGene ORF clones in mouse, rat for JAK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JAK2 (NM_004972)
    Sino Biological Human cDNA Clone for JAK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAK2
    Addgene plasmids for JAK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for JAK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for JAK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAK2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11905) for JAK2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    JAK2_HUMAN, O60674: Endomembrane system; Peripheral membrane protein (By similarity). Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endosome4
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum2
    extracellular2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10502458
    GO:0005737cytoplasm IDA10502458
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0005901caveola ISS--

    Find genes that share ontologies with JAK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for JAK2 About   (see all 86)  
    See pathways by source

    SuperPathContained pathways About
    1Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33
    2Development EPO induced Jak STAT pathway
    Development EPO induced Jak STAT pathway0.42
    EPO signaling pathway0.34
    EPO Receptor Signaling0.42
    3Translation Insulin regulation of translation
    Development CNTF receptor signaling0.43
    ErbB2/ErbB3 signaling events0.31
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    4Immune response IL 23 signaling pathway
    Immune response IL 23 signaling pathway0.41
    IL23-mediated signaling events0.38
    Development PDGF signaling via STATs and NF kB0.41
    5IL-17 Family Signaling Pathways
    IL17 signaling pathway0.51
    Mucin expression in CF via IL 6, IL 17 signaling pathways0.48


    Find genes that share SuperPaths with JAK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 R&D Systems Pathways for JAK2
        Th1 Differentiation
    VEGF - VEGF R2 Signaling Pathways
    Th17 Differentiation

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for JAK2 (see all 27)
        MSP-RON Signaling
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Interferon Pathway
    Cellular Transformation by HTLV1

    2 Cell Signaling Technology (CST) Pathways for JAK2
        Tyrosine Kinases / Adaptors
    Jak/Stat Pathway

    Selected GeneGo (Thomson Reuters) Pathways for JAK2 (see all 24)
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Immune response Bacterial infections in normal airways
    Development CNTF receptor signaling
    Development EGFR signaling pathway
    Immune response Oncostatin M signaling via JAK-Stat in human cells

    Selected BioSystems Pathways for JAK2 (see all 35)
        EGFR1 Signaling Pathway
    EPO Receptor Signaling
    Type II interferon signaling (IFNG)
    AGE/RAGE pathway
    Oncostatin M Signaling Pathway

    2 Sino Biological Pathways for JAK2
        EGFR Signaling Pathway
    Death Receptor Signaling

    Selected Reactome Pathways for JAK2 (see all 10)
        Interferon gamma signaling
    Prolactin receptor signaling
    Regulation of IFNG signaling
    Interleukin receptor SHC signaling
    Interleukin-6 signaling


    Selected Kegg Pathways  (Kegg details for JAK2) (see all 12):
        Chemokine signaling pathway
    PI3K-Akt signaling pathway
    Jak-STAT signaling pathway
    Cholinergic synapse
    Prolactin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JAK2 (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Leukemia in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for JAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for JAK2 (O606741, 2, 3 ENSP000003710674) via UniProtKB, MINT, STRING, and/or I2D (see all 281)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSF2RBP329271, 2, 3, ENSP000003840534EBI-518647,EBI-1809771 MINT-8286707 I2D: score=5 STRING: ENSP00000384053
    SH2B1Q9NRF22, 3, ENSP000003371634MINT-8037650 MINT-8037691 I2D: score=7 STRING: ENSP00000337163
    PIK3R1P279862, 3, ENSP000002743354MINT-8286707 MINT-8112051 I2D: score=6 STRING: ENSP00000274335
    SOCS1O155242, 3, ENSP000003294184MINT-8033432 I2D: score=8 STRING: ENSP00000329418
    BRCA1P383982, 3, ENSP000003502834MINT-13705 I2D: score=4 STRING: ENSP00000350283
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 77):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IEA--
    GO:0006468protein phosphorylation TAS9670957
    GO:0006915apoptotic process ISS--
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process ISS--
    GO:0006928cellular component movement TAS9670957

    Find genes that share ontologies with JAK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for JAK2
    Selected ApexBio Compounds for JAK2 (see all 36)     About this table
    CompoundAction CAS #
    1,2,3,4,5,6-HexabromocyclohexanePotently and directly inhibits JAK2[1837-91-8]
    AZ 960novel inhibitor of JAKs[905586-69-8]
    AZD1480novel small-molecule JAK inhibitor[935666-88-9]
    Baricitinib (LY3009104, INCB028050)new selective orally bioavailable inhibitor of JAK1 or JAK2. [1187594-09-7]
    Baricitinib phosphateselective orally bioavailable JAK1/JAK2 inhibitor[1187595-84-1]
    BMS-911543potent and selective inhibitor of JAK2[1271022-90-2]
    CEP-33779highly selective, orally active inhibitor of JAK2[1257704-57-6]
    CercosporamidePotent inhibitor of Mnk2 and JAK3[131436-22-1]
    Cucurbitacin ISelective inhibitor of STAT3/JAK2[2222-7-3]
    CYT387potent and selective inhibitor of JAK1, JAK2,TYK2[1056634-68-4]

    Compounds for JAK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CP 690550 citratePotent JAK inhibitor[540737-29-9]
    1,2,3,4,5,6-Hexabromocyclohexane Inhibits JAK2 autophosphorylation[1837-91-8]
    TCS 21311Potent JAK3 inhibitor. Also inhibits GSK-3beta and PKC[1260181-14-3]
    ZM 449829 Potent, selective JAK3 inhibitor [4452-06-6]
    Lestaurtinib JAK2, FLT3 and TrkA inhibitor [111358-88-4]

    2 HMDB Compounds for JAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    6 DrugBank Compounds for JAK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RuxolitinibINCB 18424 (see all 3)941678-49-5targetinhibitor23514013 23061804
    2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE-- --target--10592235
    3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile-- --target--10592235
    4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamide-- --target--10592235
    4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUM-- --target--10592235
    5-phenyl-1H-indazol-3-amine-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for JAK2 gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 88.7 909 11593427 (9), 7591091 (5), 7579336 (5), 8068943 (4) (see all 99)
    gp 130 70.4 26 7896787 (3), 10491180 (2), 12591746 (2), 9126968 (1) (see all 20)
    anagrelide 66.4 2 16325696 (1), 16810617 (1)
    ly294002 64.4 18 11756417 (2), 16912864 (1), 10940312 (1), 19162037 (1) (see all 12)
    beta-tyrosine 61.7 5 11536325 (4), 8695792 (1)
    phosphatidylinositol 61.4 39 16684834 (2), 17565041 (2), 8895329 (2), 12672794 (2) (see all 29)
    imatinib 56.5 31 17533047 (2), 17090651 (2), 17688946 (2), 18071309 (1) (see all 14)
    pd 98,059 56.4 18 16752079 (1), 18006466 (1), 15695623 (1), 17197193 (1) (see all 17)
    phosphotyrosine 54.8 11 9126968 (1), 9164861 (1), 8650199 (1), 7956946 (1) (see all 9)
    cucurbitacin i 52 2 16707113 (1)



    Find genes that share compounds with JAK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for JAK2 gene: 
    NM_004972.3  

    Unigene Cluster for JAK2:

    Janus kinase 2
    Hs.656213  [show with all ESTs]
    Unigene Representative Sequence: NM_004972
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476574 ENST00000381652(uc010mhm.3 uc003ziw.3) ENST00000487310
    ENST00000539801 ENST00000544510
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat JAK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate JAK2 (see all 18):
    hsa-miR-623 hsa-miR-607 hsa-miR-373* hsa-miR-204 hsa-miR-548x hsa-miR-3121-3p hsa-miR-375 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidJAK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for JAK2
    Predesigned siRNA for gene silencing in human, mouse, rat JAK2
    Clone
    Products:
         
    OriGene clones in human, mouse for JAK2 (see all 6)
    OriGene ORF clones in mouse, rat for JAK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: JAK2 (NM_004972)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for JAK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAK2
    Addgene plasmids for JAK2 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for JAK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JAK2
      QuantiTect SYBR Green Assays in human, mouse, rat JAK2
      QuantiFast Probe-based Assays in human, mouse, rat JAK2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11905) for JAK2 

    Additional mRNA sequence: 

    AF001362.1 AF005216.1 AF058925.1 AK128670.1 AK292525.1 AK302618.1 AK308668.1 BC039695.1 
    JN021381.1 

    8 DOTS entries:

    DT.310729  DT.95267922  DT.97762358  DT.86842322  DT.91744291  DT.91936907  DT.40233388  DT.95256905 

    Selected AceView cDNA sequences (see all 71):

    BX482718 BE856473 AI367869 BQ130120 CB153843 AU134500 NM_004972 AV729875 
    BC039695 CK905819 AF005216 D79610 AI376272 BC043187 BU634092 CD557645 
    AA464860 D81796 AI923337 D61985 AF001362 AW104868 CB266315 CA406354 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    JAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    JAK2 Expression
    About this image


    JAK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
     
     Thymus (Hematopoietic System)
             Thymus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Brain (Nervous System)
             Cerebellum
    JAK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    JAK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656213

    UniProtKB/Swiss-Prot: JAK2_HUMAN, O60674
    Tissue specificity: Ubiquitously expressed throughout most tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including JAK2 (see all 10): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat
              Th17 Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Leukemia in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for JAK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JAK2
    QuantiTect SYBR Green Assays in human, mouse, rat JAK2
    QuantiFast Probe-based Assays in human, mouse, rat JAK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for JAK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Jak21 , 5 Janus kinase 21, 5 88.6(n)1
    93.73(a)1
      19 (23.73 cM)5
    164521  NM_008413.31  NP_032439.21 
     292518285 
    chicken
    (Gallus gallus)
    Aves JAK21 Janus kinase 2 81.25(n)
    87.23(a)
      374199  NM_001030538.1  NP_001025709.1 
    lizard
    (Anolis carolinensis)
    Reptilia JAK26
    Janus kinase 2
    84(a)
    1 ↔ 1
    2(52172417-52285421)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31122 Xenopus laevis transcribed sequence with moderate similarity more 80.23(n)    BX852789.1 
    zebrafish
    (Danio rerio)
    Actinopterygii jak2a2 Janus kinase 2a 71.73(n)   30307  AJ005690.1 


    ENSEMBL Gene Tree for JAK2 (if available)
    TreeFam Gene Tree for JAK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for JAK2 gene
    SYK2  TNK12  JAK32  TNK22  TYK22  ERBB42  JAK12  ERBB32  
    PTK22  ERBB22  ZAP702  EGFR2  PTK2B2  
    Selected SIMAP similar genes for JAK2 using alignment to 6 protein entries:     JAK2_HUMAN (see all proteins) (see all similar genes):
    FLT4    JAK3    ABL1    BRAF    MET    JAK1
    TXK    DKFZp434L0319    EGFR    RYK    TYK2    BTK kinase deficient isoform 2
    EPHA2    RPS6KA2    TNK2    PTK7    BTK kinase deficient isoform 6    DKFZp564L2416

    Find genes that share paralogs with JAK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for JAK2 (see all 3502)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0675344
    Thrombocythemia 3 (THCYT3)4--see VAR_0675342 V I mis40--------
    VAR_0326964
    Leukemia, acute myelogenous (AML)4--see VAR_0326962 K N mis40--------
    VAR_0417174
    An ovarian serous carcinoma sample4--see VAR_0417172 K Q mis40--------
    VAR_0326974
    Thrombocythemia 3 (THCYT3)4--see VAR_0326972 V F mis40--------
    rs773754931,2
    Cother15069327(+) TATGTA/G/TTCTGT 3 I V F mis11NA 4492
    rs2002330491,2
    C--4952477(+) TTGTTC/TTTTTT 1 -- int10--------
    rs583466921,2
    C--4956753(+) TACCAA/GATTGC 1 -- int11Minor allele frequency- G:0.00WA 2
    rs2011088851,2
    --4956753(+) TACCA-/GATTGC 1 -- int10--------
    rs572915451,2
    C--4956754(+) ACCAGT/ATTGCA 1 -- int11Minor allele frequency- A:0.00WA 2
    rs556894191,2
    C--4959401(+) TATCA-/GAGTGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for JAK2 (4985033 - 5128183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for JAK2 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670206CNV Deletion23128226
    esv2517112CNV Deletion19546169
    nsv436602CNV Deletion17901297
    esv267944CNV Insertion20981092
    dgv8017n71CNV Loss21882294
    nsv438090CNV Loss16468122
    dgv1208n67CNV Loss20364138
    nsv512086CNV Loss21212237
    dgv8018n71CNV Loss21882294
    nsv824825CNV Loss20364138

    Human Gene Mutation Database (HGMD): JAK2
    Locus Specific Mutation Databases (LSDB): JAK2

    Selected Site Specific Mutation Identification with PCR Assays for JAK2 (see all 7):
    Cosmic IdAA Change
    29300p.R683G
    24439p.K539L
    29024p.K539L
    27147p.I540_E543>MK
    26735p.R541_E543>K
    Selected Site Specific Cancer Mutation PCR Panels containing JAK2 (see all 7):
    Tyrosine Kinases & Cell Signaling Pathways Panel 384HT
    Oncogene and Tumor Suppressor Panel 384HT
    Lymphoid Neoplasms
    Hematopoietic Neoplasms
    Lung and Colon Cancers (Expanded Panel) 384HT
    SeqTarget long-range PCR primers for resequencing JAK2
    DNA2.0 Custom Variant and Variant Library Synthesis for JAK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 147796   
    OMIM disorders: 263300  614521  254450  600880  601626  133100  
    UniProtKB/Swiss-Prot: JAK2_HUMAN, O60674
  • Note=Chromosomal aberrations involving JAK2 are found in both chronic and acute forms of eosinophilic,
    lymphoblastic and myeloid leukemia. Translocation t(8;9)(p22;p24) with PCM1 links the protein kinase domain of
    JAK2 to the major portion of PCM1. Translocation t(9;12)(p24;p13) with ETV6
  • Budd-Chiari syndrome (BDCHS) [MIM:600880]: A syndrome caused by obstruction of hepatic venous outflow
    involving either the hepatic veins or the terminal segment of the inferior vena cava. Obstructions are generally
    caused by thrombosis and lead to hepatic congestion and ischemic necrosis. Clinical manifestations observed in
    the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites. Budd-Chiari
    syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and
    thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency. Budd-Chiari syndrome
    is a rare but typical complication in patients with polycythemia vera. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry
  • Polycythemia vera (PV) [MIM:263300]: A myeloproliferative disorder characterized by abnormal
    proliferation of all hematopoietic bone marrow elements, erythroid hyperplasia, an absolute increase in total
    blood volume, but also by myeloid leukocytosis, thrombocytosis and splenomegaly. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Thrombocythemia 3 (THCYT3) [MIM:614521]: A myeloproliferative disorder characterized by excessive
    platelet production, resulting in increased numbers of circulating platelets. It can be associated with
    spontaneous hemorrhages and thrombotic episodes. Note=The disease may be caused by mutations affecting the gene
    represented in this entry
  • Myelofibrosis (MYELOF) [MIM:254450]: A disorder characterized by replacement of the bone marrow by
    fibrous tissue, occurring in association with a myeloproliferative disorder. Clinical manifestations may include
    anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy,
    hepatomegaly, portal hypertension. Note=The disease is caused by mutations affecting the gene represented in this
    entry
  • Leukemia, acute myelogenous (AML) [MIM:601626]: A subtype of acute leukemia, a cancer of the white blood
    cells. AML is a malignant disease of bone marrow characterized by maturational arrest of hematopoietic precursors
    at an early stage of development. Clonal expansion of myeloid blasts occurs in bone marrow, blood, and other
    tissue. Myelogenous leukemias develop from changes in cells that normally produce neutrophils, basophils,
    eosinophils and monocytes. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for JAK2 (see all 28):    
    About MalaCards
    jak2-related budd-chiari syndrome    myelofibrosis    myeloid leukemia, acute, m4/m4eo subtype, somatic    erythrocytosis, somatic
    polycythemia vera    thrombocythemia 3    acquired polycythemia    hepatic vein thrombosis
    leukemia, acute myeloid, reduced survival in    acute erythroid leukemia    moyamoya disease 5    leukemia, acute myeloid, somatic
    myelofibrosis, somatic    polycythemia    3q21q26 syndrome    multisystemic smooth muscle dysfunction syndrome
    myelofibrosis with myeloid metaplasia, somatic    thrombocythemia 1    chronic myeloproliferative disease    thrombocytosis

    7 diseases from the University of Copenhagen DISEASES database for JAK2:
    Polycythemia     Myeloma     Hemorrhagic disease     Leukemia
    Anemia     Vascular disease     Lymphoma

    Find genes that share disorders with JAK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for JAK2 gene (see all 88)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polycythemia vera 95.5 127 17267906 (3), 19252176 (3), 18056003 (2), 18059484 (2) (see all 99)
    myeloproliferative neoplasm 95 62 18538168 (5), 19799128 (2), 19287385 (2), 20008300 (2) (see all 57)
    thrombocythemia essential 94.8 67 17213018 (1), 17361221 (1), 17317861 (1), 18092959 (1) (see all 64)
    primary myelofibrosis 94.4 24 18032973 (2), 17361221 (1), 20008249 (1), 18429051 (1) (see all 21)
    myeloproliferative disorders 94.3 189 16998940 (5), 17984312 (4), 18790796 (3), 19174256 (2) (see all 99)
    idiopathic myelofibrosis 91 34 16293597 (2), 17213018 (1), 17317861 (1), 17875526 (1) (see all 27)
    myelofibrosis 87.1 34 16456374 (2), 20215535 (2), 19669209 (2), 17133423 (1) (see all 27)
    chronic myeloproliferative disease 84 10 19880761 (3), 17213018 (1), 18084761 (1), 19372714 (1) (see all 8)
    thrombocytosis 83.9 40 19999391 (2), 16325696 (2), 19222478 (2), 16781482 (1) (see all 35)
    erythrocytosis 83.7 46 17920755 (3), 17267906 (3), 18056003 (2), 18055983 (2) (see all 29)

    Genetic Association Database (GAD): JAK2
    Human Genome Epidemiology (HuGE) Navigator: JAK2 (218 documents)
    Tumor Gene Database (TGDB): JAK2

    Export disorders for JAK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for JAK2 gene, integrated from 10 sources (see all 2028):
    (articles sorted by number of sources associating them with JAK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The JAK2 V617F mutation in de novo acute myelogenous leukemias. (PubMed id 16247455)1, 2, 4, 9 Lee J.W.... Lee S.H. (Oncogene 2006)
    2. No evidence for the JAK2 (V617F) or JAK2 exon 12 mutations in primary mediastinal large B-cell lymphoma. (PubMed id 19704259)1, 4, 9 Wu D....Kutok J.L. (Diagn. Mol. Pathol. 2009)
    3. JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. (PubMed id 17267906)1, 2, 9 Scott L.M.... Green A.R. (N. Engl. J. Med. 2007)
    4. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. (PubMed id 19783980)1, 2, 9 Dawson M.A.... Kouzarides T. (Nature 2009)
    5. Increased risk of pregnancy complications in patients with essential thrombocythemia carrying the JAK2 (617V&gt;F) mutation. (PubMed id 17426257)1, 4, 9 Passamonti F....Lazzarino M. (Blood 2007)
    6. Cloning and characterization of the human homolog of mouse Jak2. (PubMed id 9446644)1, 2, 9 Dalal I.... Roifman C.M. (Blood 1998)
    7. A novel JAK2 exon 12 mutation identified in the retrospective analysis of paraffin-embedded tissues of polycythemia vera patients. (PubMed id 19430293)1, 4, 9 Burjanivova T....Plank L. (Diagn. Mol. Pathol. 2009)
    8. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. (PubMed id 18805579)1, 4, 9 Bercovich D....Izraeli S. (Lancet 2008)
    9. Correlation of JAK2 V617F mutant allele quantitation with clinical presentation and type of chronic myeloproliferative neoplasm. (PubMed id 19880761)1, 4, 9 Malysz J. and Crisan D. (Ann. Clin. Lab. Sci. 2009)
    10. JAK2 and MPL gene mutations in V617F-negative myeloproliferative neoplasms. (PubMed id 19643476)1, 4, 9 Siemiatkowska A....Limon J. (Leuk. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3717 HGNC: 6192 AceView: JAK2 Ensembl:ENSG00000096968 euGenes: HUgn3717
    ECgene: JAK2 Kegg: 3717 H-InvDB: JAK2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for JAK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JAK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for JAK2 gene:
    Search GeneIP for patents involving JAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Purified and/or Recombinant JAK2 Protein
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of JAK2
     
     EMD Millipore genomic analysis products

      
     Antibodies for JAK2 (Jak2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for JAK2   OriGene RNAi products in human, mouse, rat for JAK2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for JAK2   OriGene clones in human, mouse for JAK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for JAK2   OriGene Purified Protein for JAK2  
     OriGene ORF clones in mouse, rat for JAK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for JAK2   OriGene Custom Protein Services for JAK2  

     
     
     Block miRNA regulation of human, mouse, rat JAK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing JAK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat JAK2 Predesigned siRNA for gene silencing in human, mouse, rat JAK2
     QuantiFast Probe-based Assays in human, mouse, rat JAK2 QuantiTect SYBR Green Assays in human, mouse, rat JAK2
     PCR Arrays including human, mouse, rat JAK2 Search Chromatin IP Primers for JAK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat JAK2  GeneGlobe Interaction Network for JAK2
     Regulatory tfbs in JAK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for JAK2 GenScript cDNA clones with any tag delivered in your preferred vector for JAK2
     GenScript Custom Assay Services for JAK2 GenScript Custom overexpressing Cell Line Services for JAK2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for JAK2 

     Tocris compounds for JAK2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for JAK2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for JAK2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     JAK2 antibodies
     JAK2 proteins
     Antibodies for JAK2
     See all of Abcam's Antibodies, Kits and Proteins for JAK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for JAK2
     Antibodies for JAK2
     ELISAs for JAK2
     CLIAs for JAK2



     Browse ESI BIO Cell Lines and PureStem Progenitors for JAK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAK2
     SwitchGear 3'UTR luciferase reporter plasmids for JAK2
     SwitchGear Promoter luciferase reporter plasmids for JAK2
     ThermoFisher Antibodies for JAK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAK2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for JAK2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for JAK2
     Search LSBio for Antibodies for JAK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for JAK2
     Addgene plasmids for JAK2
      Search eBioscience for proteins for JAK2
      Search eBioscience for elisas for JAK2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      JAK2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4