JAGN1 Gene
protein-coding GIFtS: 38
GCID: GC03P009932
|
|
jagunal homolog 1 (Drosophila)
| |
Aliases
for JAGN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Jagunal Homolog 1 (Drosophila)1 2 | | GL0091 2 | | FLJ146021 | | Protein Jagunal Homolog 12 |
Export aliases for JAGN1 gene to outside databasesPrevious GC identifers: GC03P009908 GC03P009909 GC03P009910 GC03P009911 GC03P009912 GC03P009868 |
Summaries
for JAGN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9Function: May be required for endoplasmic reticulum organization (By similarity)
|
Genomic Views
for JAGN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the JAGN1 gene promoter:
AP-1 ATF-2 c-Jun NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for JAGN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAGN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25.2 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.2JAGN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P009932: view genomic region
(about GC identifiers)
Start:
|
9,932,238 bp from pter |
End:
|
9,936,033 bp from pter |
Size:
|
3,796 bases |
Orientation:
|
plus strand |
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Proteins
for JAGN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9 (See
protein sequence)Recommended Name: Protein jagunal homolog 1 Size: 183 amino acids; 21125 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: Q8NCF6 Q96SW1Explore the universe of human proteins at neXtProt for JAGN1: NX_Q8N5M9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5M9
JAGN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115881.3
ENSEMBL proteins: ENSP00000306106
Human Recombinant Protein Products for JAGN1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
JAGN1 for ontologies About GeneDecksing
JAGN1 Antibody Products:
Assay Products for JAGN1: |
Protein
Domains /
Families
for JAGN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
JAGN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5M9ProtoNet protein and cluster: Q8N5M9 UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9Similarity: Belongs to the jagunal family |
Function
for JAGN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: JAGN1_HUMAN, Q8N5M9Function: May be required for endoplasmic reticulum organization (By similarity)Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAGN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAGN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAGN1 |
|
Pathways & Interactions
for JAGN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for JAGN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for JAGN1 (ENSP000003061064) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
|
Drugs & Compounds
for JAGN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for JAGN1
Search CenterWatch for drugs/clinical trials and news about JAGN1
|
Transcripts
for JAGN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for JAGN1 gene: NM_032492.3 Unigene Cluster for JAGN1: Jagunal homolog 1 (Drosophila) Hs.24054 [show with all ESTs]Unigene Representative Sequence: AY3754752 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307768(uc003btt.4) ENST00000489724
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for JAGN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for JAGN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: JAGN1 (NM_032492) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for JAGN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat JAGN1 |
Additional cDNA sequence: AF212230.1 AK027508.1 AK074760.1 AK225756.1 AY375475.1 BC008507.1 BC032101.2 6 DOTS entries: DT.100786472 DT.453960 DT.91754993 DT.100786467 DT.120895885 DT.101971224 24/237 AceView cDNA sequences (see all 237): AA234485 CR615913 BQ637060 AW079295 BU736892 BU192865 BU731528 CR610826 AL548891 CR626291 BU674942 AA456724 CA429210 CR626407 AL548862 CR601340 AI202803 BC008507 CR622444 CR621319 AL519891 CD721780 BM931142 BU631892
GeneLoc Exon Structure
|
Expression
for JAGN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| JAGN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCAGTT
About this image
See JAGN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for JAGN1
SOURCE GeneReport for Unigene cluster: Hs.24054
SABiosciences Custom PCR Arrays for JAGN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for JAGN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat JAGN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat JAGN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat JAGN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAGN1 |
Orthologs
for JAGN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for JAGN1 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Jagn11 , 5 |
jagunal homolog 1 (Drosophila)1, 5 |
92.71(n)1
97.81(a)1 |
|
6 (52.76 cM)5
677671 NM_026365.31 NP_080641.11
1134425695 |
lizard
(Anolis carolinensis) |
Reptilia |
JAGN16 |
-- |
83(a) |
1 ↔ 1 |
2(191341092-191344915) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.166242 |
Xenopus laevis transcribed sequence with weak similarity more |
74.86(n) |
|
BJ033889.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb07b072 |
Transcribed sequence with weak similarity to protein more |
76.98(n) |
|
CD599765.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
jagn6 |
jagunal |
29(a) |
1 ↔ 1 |
3R(1605031-1607030) |
worm
(Caenorhabditis elegans) |
Secernentea |
K05C4.26 |
Protein jagunal homolog |
30(a) |
1 ↔ 1 |
I(14720576-14721968) |
ENSEMBL Gene Tree for JAGN1 (if available)
TreeFam Gene Tree for JAGN1 (if available) |
Paralogs
for JAGN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for JAGN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for JAGN1 (9932238 - 9936033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for JAGN1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing JAGN1 |
|
Disorders
/ Diseases
for JAGN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for JAGN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for JAGN1 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with JAGN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. (PubMed id 17389229)2 Lee S. and Cooley L. (2007)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for JAGN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing JAGN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing JAGN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing JAGN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for JAGN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for JAGN1 gene:
Search GeneIP for patents involving JAGN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for JAGN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for JAGN1 |
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