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JAGN1 Gene

protein-coding GIFtS: 41

GC03P009911

jagunal homolog 1 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ14602 ^¹, ²
GL009 ^¹, ²

Descriptions
jagunal homolog 1 ^²
jagunal homolog 1 (Drosophila) ^²

External Ids
HGNC: 26926¹
Entrez Gene: 84522²
UniProtKB: Q8N5M9³
Ensembl: ENSG00000171135⁷

Search outside databases for aliases for JAGN1 gene

Previous GC identifers: GC03P009908 GC03P009909 GC03P009910

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9

Function: May be required for endoplasmic reticulum organization (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the JAGN1 gene

Entrez Gene cytogenetic band: 3p25.2 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.2

JAGN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P009911: (about GC identifiers)

Start:	9,907,272 bp from pter
End:	9,911,029 bp from pter
Size:	3,758 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9 (See protein sequence)

Recommended Name: Protein jagunal homolog 1

Size: 183 amino acids; 21125 Da

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: Q8NCF6 Q96SW1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_115881.3

ENSEMBL proteins:

ENSP00000306106

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for JAGN1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for JAGN1

Assays for JAGN1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8N5M9

ProtoNet protein and cluster: Q8N5M9

UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9

Similarity: Belongs to the jagunal family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAGN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032492

Applied Biosystems Silencer® siRNAs for JAGN1

Sigma-Aldrich siRNA for JAGN1

Sigma-Aldrich shRNA for JAGN1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for JAGN1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032492
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032492
untagged cDNA clone in CMV expression vector: NM_032492

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032492

UniProtKB/Swiss-Prot: JAGN1_HUMAN, Q8N5M9

Function: May be required for endoplasmic reticulum organization (By similarity)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for JAGN1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (JAGN1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032492

Sigma-Aldrich siRNA for JAGN1

Sigma-Aldrich shRNA for JAGN1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032492

REFSEQ mRNAs for JAGN1 gene:

NM_032492.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032492

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032492
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032492
                                 untagged cDNA clone in CMV expression vector: NM_032492

Additional cDNA sequence:

AF212230.1 AK027508.1 AK074760.1 AK225756.1 AY375475.1 BC008507.1 BC032101.2 CR591616.1

CR592606.1 CR598658.1 CR601340.1 CR610826.1 CR615427.1 CR615913.1 CR616583.1 CR621319.1

CR622444.1 CR626291.1 CR626407.1 CR626609.1

6 DOTS entries:

DT.100786472 DT.453960 DT.100786467 DT.120895885 DT.91754993 DT.101971224

24/237 AceView cDNA sequences (see all 237 ):

AL548862 BU731528 BC008507 CR615913 AL519891 BU674942 AW079295 CD721780

AL548891 CR626407 AA234485 CR601340 CR592606 BG425004 AI202803 BU192865

CR616583 CR626291 BM931142 CR598658 BU631892 CR610826 AW004793 CA446568

highest scoring ESTs for JAGN1:

AA393099 AA191001 AA205313 AA234485 AA236451 AA296938 AA298748 AA456724 AA568605 AA595242

Unigene Cluster for JAGN1:

Jagunal homolog 1 (Drosophila)

Hs.24054 [show with all ESTs]

Unigene Representative Sequence: AY375475

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000307768

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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JAGN1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for JAGN1

¹ / ² / ³

3 probe-sets matching JAGN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50358_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA393099	1.00	1.00	1.00	1
223104_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF212230	0.80	1.00	0.91	1
223104_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCTGGCAGTT

SOURCE GeneReport for Unigene cluster: Hs.24054

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for JAGN1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	JAGN1¹	--	jagunal homolog 1 (Drosophila)	94.54(n) 97.81(a)	484661 XM_541776.2 XP_541776.1
chimpanzee (Pan troglodytes)	JAGN1¹	--	jagunal homolog 1 (Drosophila)	99.27(n) 98.91(a)	460157 XM_516267.2 XP_516267.2
cow (Bos taurus)	JAGN1¹	--	jagunal homolog 1 (Drosophila)	93.08(n) 97.27(a)	539101 NM_001046450.1 NP_001039915.1
rat (Rattus norvegicus)	Jagn1¹	--	jagunal homolog 1 (Drosophila)	91.77(n) 97.4(a)	502872 XM_001054553.1 XP_001054553.1
mouse (Mus musculus)	Jagn1^{1, 5}	6⁵	jagunal homolog 1 (Drosophila)^{1, 5}	92.71(n)¹ 97.27(a)¹	67767¹ NM_026365.2¹ NP_080641.1¹ AK003673⁵ AK017953⁵ (see all 16)

About this table Species with no ortholog for JAGN1

ENSEMBL Gene Tree for JAGN1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/57 NCBI SNPs in JAGN1 are shown (see all 57 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs279558^1,2	A,C,F,H,O	9907337(+)	`GGTCAC/GTGGGC`	1	--	ut5¹ ese³		6		MN EA EU WA	1336
	rs279542^1,2	A,C,F,H,O	9910773(+)	`ATCTAG/CCTTAG`	1	--	ut3¹		13		NS EA NA EU WA	700
	rs279543^1,2	A,C,F,H	9910263(+)	`TGACCA/GACAGC`	1	--	ut3¹ ese³		5		MN EU EA WA	602
	rs279559^1,2	C,F,H,O	9907112(+)	`TACAGC/TTTAAG`	1	--	ng5¹		5		MN EU EA WA	602
--	rs7433876^1,2	A,C	9911315(+)	`ccattC/Ttgcct`	1	--	ng3¹		0	--	--	--	--
--	rs6807965^1,2	A	9911420(+)	`ggatgC/Ttctcg`	1	--	ng3¹		0	--	--	--	--
--	rs6807973^1,2	A	9911445(+)	`tgatcC/Tgccct`	1	--	ng3¹		0	--	--	--	--
	rs279553^1,2	A,C,F,H	9909605(-)	`TTGAGA/GGTCAC`	1	T/T	syn¹ ese³		17		MN EU EA WA NA	2966
--	rs279556^1,2	A,C	9908837(-)	`ctgtaC/Gtccca`	1	--	int¹		0	--	--	--	--
--	rs279554^1,2	C,O	9909231(-)	`GGTTAC/TGTGTG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for JAGN1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

8 PubMed articles for JAGN1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. (PubMed id 17389229)⁴ Lee S. and Cooley L. (2007)
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)³ Otsuki T....Isogai T. (2005)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)³ Suzuki Y.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)³ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 84522	HGNC: 26926	AceView: GL009	Ensembl:ENSG00000171135	euGenes: HUgn84522
ECgene: JAGN1	H-InvDB: JAGN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for JAGN1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for JAGN1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for JAGN1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for JAGN1		Browse antibodies at Sigma-Aldrich
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JAGN1 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for JAGN1

Summaries
for JAGN1

Genomic Location
for JAGN1

Proteins
for JAGN1

Protein Domains/
Families
for JAGN1

Gene Function
for JAGN1

Pathways & Interactions
for JAGN1

Drugs & Compounds
for JAGN1

Transcripts
for JAGN1

Expression
for JAGN1

Orthologs
for JAGN1

Paralogs
for JAGN1

SNPs/Variants
for JAGN1

Disorders & Mutations
for JAGN1

Medical News
for JAGN1

Publications
for JAGN1

Search for JAGN1

Genome Databases showing JAGN1

Other Databases showing JAGN1

Specialized Databases showing JAGN1

Licensable Technologies
for JAGN1

Services
for JAGN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

JAGN1 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor JAGN1

Summariesfor JAGN1

Genomic Locationfor JAGN1

Proteinsfor JAGN1

Protein Domains/Familiesfor JAGN1

Gene Functionfor JAGN1

Pathways & Interactionsfor JAGN1

Drugs & Compoundsfor JAGN1

Transcriptsfor JAGN1

Expression for JAGN1

Orthologsfor JAGN1

Paralogsfor JAGN1

SNPs/Variantsfor JAGN1

Disorders & Mutationsfor JAGN1

Medical Newsfor JAGN1

Publicationsfor JAGN1

Search for JAGN1

Genome Databases showing JAGN1

Other Databases showing JAGN1

Specialized Databases showing JAGN1

Licensable Technologiesfor JAGN1

Servicesfor JAGN1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for JAGN1

Summaries
for JAGN1

Genomic Location
for JAGN1

Proteins
for JAGN1

Protein Domains/
Families
for JAGN1

Gene Function
for JAGN1

Pathways & Interactions
for JAGN1

Drugs & Compounds
for JAGN1

Transcripts
for JAGN1

Expression
for JAGN1

Orthologs
for JAGN1

Paralogs
for JAGN1

SNPs/Variants
for JAGN1

Disorders & Mutations
for JAGN1

Medical News
for JAGN1

Publications
for JAGN1

Licensable Technologies
for JAGN1

Services
for JAGN1