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Aliases for JAG2 Gene

Aliases for JAG2 Gene

  • Jagged 2 2 3
  • HJ2 3 4
  • Protein Jagged-2 3
  • Jagged2 4
  • SER2 3

External Ids for JAG2 Gene

Summaries for JAG2 Gene

Entrez Gene Summary for JAG2 Gene

  • The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for JAG2 Gene

JAG2 (Jagged 2) is a Protein Coding gene. Diseases associated with JAG2 include ossifying fibroma and shipyard eye. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is NOTCH2.

UniProtKB/Swiss-Prot for JAG2 Gene

  • Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

Gene Wiki entry for JAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAG2 Gene

Genomics for JAG2 Gene

Genomic Location for JAG2 Gene

Start:
105,140,981 bp from pter
End:
105,168,824 bp from pter
Size:
27,844 bases
Orientation:
Minus strand

Genomic View for JAG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for JAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAG2 Gene

Regulatory Elements for JAG2 Gene

Proteins for JAG2 Gene

  • Protein details for JAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y219-JAG2_HUMAN
    Recommended name:
    Protein jagged-2
    Protein Accession:
    Q9Y219
    Secondary Accessions:
    • Q9UE17
    • Q9UE99
    • Q9UNK8
    • Q9Y6P9
    • Q9Y6Q0

    Protein attributes for JAG2 Gene

    Size:
    1238 amino acids
    Molecular mass:
    133367 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JAG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for JAG2 Gene

Proteomics data for JAG2 Gene at MOPED

Post-translational modifications for JAG2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn153, Asn570, Asn619, Asn752, and Asn1058

Other Protein References for JAG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for JAG2 Gene

Domains for JAG2 Gene

UniProtKB/Swiss-Prot:

JAG2_HUMAN
Domain:
  • Contains 1 DSL domain.:
    • Q9Y219
  • Contains 16 EGF-like domains.:
    • Q9Y219
  • Contains 1 VWFC domain.:
    • Q9Y219
genes like me logo Genes that share domains with JAG2: view

No data available for Gene Families for JAG2 Gene

Function for JAG2 Gene

Molecular function for JAG2 Gene

GENATLAS Biochemistry: NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryonic limb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervous system,retina,tooth buds,thymus,submandilas gland,stomach
UniProtKB/Swiss-Prot Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

Gene Ontology (GO) - Molecular Function for JAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005112 Notch binding IPI 9315665
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16713569
GO:0008083 growth factor activity IDA 10383933
genes like me logo Genes that share ontologies with JAG2: view
genes like me logo Genes that share phenotypes with JAG2: view

Animal Models for JAG2 Gene

MGI Knock Outs for JAG2:

miRNA for JAG2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for JAG2 Gene

Localization for JAG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAG2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for JAG2 Gene COMPARTMENTS Subcellular localization image for JAG2 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for JAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS 10910909
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with JAG2: view

Pathways for JAG2 Gene

genes like me logo Genes that share pathways with JAG2: view

Pathways by source for JAG2 Gene

1 R&D Systems pathway for JAG2 Gene
1 GeneGo (Thomson Reuters Life Sciences Research) pathway for JAG2 Gene
1 Cell Signaling Technology pathway for JAG2 Gene

Gene Ontology (GO) - Biological Process for JAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0001701 in utero embryonic development IEA --
GO:0003016 respiratory system process IEA --
GO:0007049 cell cycle NAS 11549580
GO:0007154 cell communication --
genes like me logo Genes that share ontologies with JAG2: view

Transcripts for JAG2 Gene

mRNA/cDNA for JAG2 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JAG2 Gene

Jagged 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JAG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: - -

ExUns: 20b ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for JAG2 Gene

GeneLoc Exon Structure for
JAG2
ECgene alternative splicing isoforms for
JAG2

Expression for JAG2 Gene

mRNA expression in normal human tissues for JAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for JAG2 Gene

SOURCE GeneReport for Unigene cluster for JAG2 Gene Hs.433445

mRNA Expression by UniProt/SwissProt for JAG2 Gene

Q9Y219-JAG2_HUMAN
Tissue specificity: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney
genes like me logo Genes that share expressions with JAG2: view

Orthologs for JAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JAG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia JAG2 36
  • 91.97 (n)
  • 89.93 (a)
JAG2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia JAG2 36
  • 87.81 (n)
  • 89.83 (a)
JAG2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia JAG2 36
  • 81.76 (n)
  • 78.21 (a)
JAG2 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Jag2 36
  • 87.37 (n)
  • 90.55 (a)
Jag2 16
Jag2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia JAG2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia JAG2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Jag2 36
  • 88.09 (n)
  • 91.17 (a)
chicken
(Gallus gallus)
Aves JAG2 36
  • 66.81 (n)
  • 71.09 (a)
JAG2 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia JAG2 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia jag2 36
  • 64.44 (n)
  • 65.99 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01041002.1 37
  • 42 (a)
OneToMany
jag2 36
JAG2 (1 of 3) 37
  • 56 (a)
OneToMany
jag2b 36
  • 64.1 (n)
  • 61.39 (a)
jag2b 37
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ser 37
  • 33 (a)
OneToMany
Dl 38
  • 41 (a)
SP1070 38
  • 36 (a)
C901 38
  • 33 (a)
Ser 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea clec-78 37
  • 9 (a)
ManyToMany
apx-1 38
  • 33 (a)
R05G6.9 38
  • 29 (a)
Y69H2.11 38
  • 27 (a)
W02C12.1 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for JAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JAG2 Gene

ENSEMBL:
Gene Tree for JAG2 (if available)
TreeFam:
Gene Tree for JAG2 (if available)

Paralogs for JAG2 Gene

Selected SIMAP similar genes for JAG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JAG2: view

Variants for JAG2 Gene

Sequence variations from dbSNP and Humsavar for JAG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13358 -- 105,141,931(-) CCCAT(C/T)CTGGG utr-variant-3-prime
rs741859 -- 105,141,642(+) GCACG(C/T)GCCCC utr-variant-3-prime
rs760268 -- 105,154,540(-) TGGAG(C/G)CCTCT intron-variant
rs760269 -- 105,142,066(-) AAGGC(C/G/T)GGCAG utr-variant-3-prime
rs1056310 -- 105,141,278(-) ACCTG(C/G)CCCTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for JAG2 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294
nsv9175 CNV Gain 18304495
dgv659e1 CNV Complex 17122850
nsv456460 CNV Loss 19166990
dgv2021n71 CNV Loss 21882294
nsv456461 CNV Loss 19166990
nsv470679 CNV Loss 18288195
nsv902433 CNV Loss 21882294
dgv2022n71 CNV Loss 21882294
nsv902435 CNV Gain+Loss 21882294
dgv2023n71 CNV Gain+Loss 21882294
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
nsv817646 CNV Loss 17921354
dgv267n27 CNV Loss 19166990
dgv2026n71 CNV Gain 21882294
dgv2027n71 CNV Gain+Loss 21882294
dgv2028n71 CNV Loss 21882294
esv2595277 CNV Insertion 19546169
esv2662212 CNV Deletion 23128226
esv1065091 CNV Insertion 17803354
dgv414e199 CNV Deletion 23128226
esv32995 CNV Loss 17666407
dgv2029n71 CNV Loss 21882294
esv24764 CNV Loss 19812545

Relevant External Links for JAG2 Gene

HapMap Linkage Disequilibrium report
JAG2
Human Gene Mutation Database (HGMD)
JAG2

Disorders for JAG2 Gene

(3) University of Copenhagen DISEASES for JAG2 Gene

(2) Novoseek inferred disease relationships for JAG2 Gene

Disease -log(P) Hits PubMed IDs
myeloma 41.9 1
tumors 0 2

Relevant External Links for JAG2

Genetic Association Database (GAD)
JAG2
Human Genome Epidemiology (HuGE) Navigator
JAG2
genes like me logo Genes that share disorders with JAG2: view

No data available for UniProtKB/Swiss-Prot for JAG2 Gene

Publications for JAG2 Gene

  1. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PMID: 10662552) Deng Y. … Li L. (Genomics 2000) 2 3 4 23
  2. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PMID: 9315665) Luo B. … Sklar J. (Mol. Cell. Biol. 1997) 2 3 4 23
  3. Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws. (PMID: 20040020) Zhang T.H. … Zheng G.S. (J. Oral Pathol. Med. 2010) 3 23
  4. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. (PMID: 20133585) Yustein J.T. … Dang C.V. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. Analysis of coding-polymorphisms in NOTCH-related genes reveals NUMBL poly-glutamine repeat to be associated with schizophrenia in Brazilian and Danish subjects. (PMID: 16899352) Passos Gregorio S. … Dias-Neto E. (Schizophr. Res. 2006) 3 49

Products for JAG2 Gene

Sources for JAG2 Gene

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