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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

JAG2 Gene

protein-coding   GIFtS: 69
GCID: GC14M105607

jagged 2
 Explore 17 diseases affiliated with
JAG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for JAG2    

Aliases
for JAG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Jagged 21 2
HJ22
SER22
Protein Jagged-22
Jagged23
HJ22

External Ids:    HGNC: 61891   Entrez Gene: 37142   Ensembl: ENSG000001849167   OMIM: 6025705   UniProtKB: Q9Y2193   

Export aliases for JAG2 gene to outside databases

Previous GC identifers: GC14M102987 GC14M099599 GC14M103579 GC14M104679 GC14M085799


Summaries
for JAG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for JAG2:
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development.
Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The
protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219
Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By
similarity)

Gene Wiki entry for JAG2


Genomic Views
for JAG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the JAG2 gene promoter:
         AhR   USF1   NF-1   MyoD   USF2   USF-1:USF-2   E47   HEN1   USF-1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: JAG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for JAG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat JAG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32

JAG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
JAG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105607:  view genomic region     (about GC identifiers)

Start:
 105,607,318 bp from pter      End:
 105,635,161 bp from pter
Size:
 27,844 bases      Orientation:
 minus strand

Proteins
for JAG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219 (See protein sequence)
Recommended Name: Protein jagged-2 precursor  
Size: 1238 amino acids; 133367 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9UE17 Q9UE99 Q9UNK8 Q9Y6P9 Q9Y6Q0
Alternative splicing: 2 isoforms:  Q9Y219-1   Q9Y219-2   

Explore the universe of human proteins at neXtProt for JAG2: NX_Q9Y219

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y219

    • JAG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002217.3  NP_660142.1  

    ENSEMBL proteins: 
     ENSP00000328169   ENSP00000328566  
    Reactome Protein details: Q9Y219
    Human Recombinant Protein Products: 
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    Uscn Proteins for JAG2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane ISS10910909


    JAG2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for JAG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    JAG2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001881 EGF-like_Ca-bd
     IPR001774 DSL
     IPR000742 EG-like_dom
     IPR013032 EGF-like_CS
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site

    Graphical View of Domain Structure for InterPro Entry Q9Y219

    ProtoNet protein and cluster: Q9Y219

    5 Blocks protein families:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001007 von Willebrand factor
    IPB001774 Delta/Serrate/lag-2 (DSL) protein
    IPB001881 EGF-like calcium-binding
    IPB011651 Notch ligand


    UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219
    Similarity: Contains 1 DSL domain
    Similarity: Contains 16 EGF-like domains
    Similarity: Contains 1 VWFC domain


    Function
    for JAG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219
    Function: Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By
    similarity)

         Genatlas biochemistry entry for JAG2:
    NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryonic
    limb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervous
    system,retina,tooth buds,thymus,submandilas gland,stomach

    miRNA
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    hsa-miR-30c hsa-miR-4254 hsa-miR-3607-3p hsa-miR-429 hsa-miR-520d-5p hsa-miR-300 hsa-miR-30d hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmid: JAG2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IPI9315665
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI16713569
    GO:0008083growth factor activity IDA10383933


    JAG2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for JAG2:
     Increased S DNA content  Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
         Mouse knock-outs for JAG2: Jag2tm1Grid Jag2tm2.2Grid
         15/16 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Jag2) (see all 16):
     cellular  craniofacial  digestive/alimentary  embryogenesis  hearing/vestibular/ear 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  reproductive system  respiratory system 

    JAG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for JAG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/10 pathways (see all 10)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		FBXW7 Mutants and NOTCH1 in Cancer1.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 in Cancer1.00
    		Signaling by NOTCH0.77
    2NOTCH2 Activation and Transmission of Signal to the Nucleus
    		NOTCH2 Activation and Transmission of Signal to the Nucleus1.00
    		Activated NOTCH1 Transmits Signal to the Nucleus0.58
    		Signaling by NOTCH21.00
    		Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor0.43
    		Constitutive Signaling by NOTCH1 HD Domain Mutants0.62
    		Constitutive Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant0.24
    3Notch Signaling Pathway
    		Notch Signaling Pathway1.00
    		Delta-Notch Signaling Pathway0.27
    		Notch signaling pathway0.82
    4Development_Notch Signaling Pathway
    		Development_Notch Signaling Pathway1.00
    		Development Notch Signaling Pathway0.97
    5Signaling by NOTCH3
    		Signaling by NOTCH31.00
    		Signaling by NOTCH40.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for JAG2
        Development Notch Signaling Pathway


    1 Cell Signaling Technology (CST) Pathway for JAG2
        Wnt / Hedgehog / Notch

    1 GeneGo (Thomson Reuters) Pathway for JAG2
        Development Notch Signaling Pathway

    3 BioSystems Pathways for JAG2 
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway
    Notch signaling pathway

    5/21        Reactome Pathways for JAG2 (see all 21)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    FBXW7 Mutants and NOTCH1 in Cancer
    Signaling by NOTCH1 HD Domain Mutants in Cancer
    Signaling by NOTCH1 in Cancer
    Disease


    1         Kegg Pathway  (Kegg details for JAG2):
        Notch signaling pathway


    JAG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for JAG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/34 Interacting proteins for JAG2 (Q9Y2191, 2, 3 ENSP000003281694) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFI1BQ5VTD91, 2, 3, ENSP000003447824EBI-946223,EBI-946212 MINT-2860155 MINT-2856213 I2D: score=3 STRING: ENSP00000344782
    ATN1P542592, 3, ENSP000003490764MINT-2860136 MINT-2860117 I2D: score=3 STRING: ENSP00000349076
    NOTCH2Q047213, ENSP000002566464I2D: score=4 STRING: ENSP00000256646
    MFAP2P550013, ENSP000003646854I2D: score=1 STRING: ENSP00000364685
    MFNGO005873, ENSP000003494904I2D: score=1 STRING: ENSP00000349490
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0003016respiratory system process IEA--
    GO:0007049cell cycle NAS11549580
    GO:0007219Notch signaling pathway TAS--


    JAG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for JAG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for JAG2
    Search CenterWatch for drugs/clinical trials and news about JAG2 

    Transcripts
    for JAG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for JAG2 gene (2 alternative transcripts): 
    NM_002226.4  NM_145159.2  

    Unigene Cluster for JAG2:

    Jagged 2
    Hs.433445  [show with all ESTs]
    Unigene Representative Sequence: NM_002226
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000331782(uc001yqf.3 uc001yqg.3) ENST00000347004(uc001yqh.3)
    ENST00000546616 ENST00000553244 ENST00000553051

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF003521.1 AF020201.1 AF029778.1 AF029779.1 BC032053.1 Y14330.1 

    5 DOTS entries:

    DT.100747349  DT.444013  DT.97833334  DT.120762392  DT.92057622 

    9 AceView cDNA sequences:

    NM_145159 NM_002226 CR618490 AF020201 Y14330 AF029779 AF003521 BC032053 
    AF029778 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for JAG2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b ^ 21 ^ 22 ^ 23
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for JAG2

    Expression
    for JAG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    JAG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGTTGGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    JAG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Primitive StreakNotochordNotochord CellsCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See JAG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for JAG2

    SOURCE GeneReport for Unigene cluster: Hs.433445

    UniProtKB/Swiss-Prot: JAG2_HUMAN, Q9Y219
    Tissue specificity: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low
    expression in brain, lung, liver and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including JAG2: 
              Growth Factors in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Hematopoiesis in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for JAG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for JAG2 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves JAG21 jagged 2 67.08(n)
    71.37(a)    		   776138  XM_001235688.2  XP_001235689.2 
    lizard
    (Anolis carolinensis)    		 Reptilia JAG26
    		 --
    		 66(a)
    		 1 ↔ 1
    		 1(79438-179577)
    zebrafish
    (Danio rerio)    		 Actinopterygii jag22 jagged2 74.94(n)   140422  AF229449.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dl3
    Ser1    		 antennal morphogenesis Notch binding3
    Serrate1    		 41(a)
    (best of 4)3
    51.38(n)1
    41.12(a)1    		   432751  NM_079803.21  NP_524527.31 
    worm
    (Caenorhabditis elegans)    		 Secernentea W02C12.13 EGF-like protein 35(a)
    (best of 4)    		   IV(4008218-4014159)   --


    ENSEMBL Gene Tree for JAG2 (if available)
    TreeFam Gene Tree for JAG2 (if available) 

    Paralogs
    for JAG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for JAG2 gene
    NOTCH42  SNED12  NOTCH12  NOTCH32  DLL32  DLL42  CRB22  NOTCH22  
    JAG12  DNER2  CRB12  DLL12  
    5 SIMAP similar genes for JAG2 using alignment to 1 protein entry:     JAG2_HUMAN:
    JAG1    CNTNAP2    DLL4    DLK1    DLL1

    JAG2 for paralogs           About GeneDecksing



    Genomic Variants
    for JAG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/625 NCBI SNPs in JAG2 are shown (see all 625)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1855829521,2
    		--105606843(+) TGCATG/TTGGTT 2 -- ds50010--------
    rs1457867101,2
    		--105606888(+) ACACCA/GTTTAA 2 -- ds50010--------
    rs1904867871,2
    		--105607091(+) CTTGTA/GAGCAA 2 -- ds50010--------
    rs28166761,2
    		C,A,--105607203(+) GAGACC/TGTCCC 2 -- ds50018Minor allele frequency- T:0.22NA WA CSA EA 367
    rs1129209511,2
    		C--105607204(+) AGACTA/GTCCCT 2 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs28166391,2
    		C,--105607205(+) GACTGC/TCCCTC 2 -- ds50018Minor allele frequency- T:0.19NA WA CSA EA 367
    rs1382434791,2
    		--105607270(+) TCAACA/GACAGA 2 -- ds50010--------
    rs1491592591,2
    		--105607304(+) ACGAGC/TGGGTC 2 -- ds50010--------
    rs1915135441,2
    		--105607305(+) CGAGCA/GGGTCT 2 -- ds50010--------
    rs1837012621,2
    		--105607422(+) TCTTTG/TGTACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for JAG2 (105607318 - 105635161 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for JAG2
         8 CNVs: 10453 3950 53303 66720 29968 29967 29966 30666
         3 Indels: 102034 11082 60164
    Human Gene Mutation Database (HGMD): JAG2

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    Disorders / Diseases
    for JAG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    JAG2 for disorders           About GeneDecksing

    OMIM gene information: 602570    OMIM disorders: --

    17 diseases for JAG2:    About MalaCards
    cleft lip/palate    cleft lip    cleft palate    macular degeneration
    chronic lymphocytic leukemia    lymphocytic leukemia    multiple myeloma    myeloma
    hepatitis b    leukemia    breast cancer    ataxia
    hepatitis    hypoxia    retinitis    schizophrenia
    pancreatitis

    2 diseases from the University of Copenhagen DISEASES database for JAG2:
    Cleft palate     Pain agnosia

    2 Novoseek disease relationships for JAG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 41.9 1 15292061 (1)
    tumors 0 2 20133585 (1), 19840488 (1)

    Genetic Association Database (GAD): JAG2
    Human Genome Epidemiology (HuGE) Navigator: JAG2 (9 documents)

    Export disorders for JAG2 gene to outside databases

    Publications
    for JAG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for JAG2 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with JAG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PubMed id 10662552)1, 2, 3, 9 Deng Y....Li L. (2000)
    2. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PubMed id 9315665)1, 2, 3, 9 Luo B.... Sklar J. (1997)
    3. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (2005)
    4. Human ligands of the Notch receptor. (PubMed id 10079256)1, 2 Gray G.E.... Artavanis-Tsakonas S. (1999)
    5. JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions. (PubMed id 9486542)1, 2 Valsecchi C.... Rugarli E.I. (1997)
    6. Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines. (PubMed id 15292061)1, 9 Houde C....Coignet L.J. (2004)
    7. Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. (PubMed id 18439488)1, 9 Fernandez L....Carlesso N. (2008)
    8. Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. (PubMed id 11006133)1, 9 Shimizu K....Hirai H. (2000)
    9. Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. (PubMed id 10958687)1, 9 Shimizu K....Hirai H. (2000)
    10. Detection of Notch signaling molecules in cemento-oss ifying fibroma of the jaws. (PubMed id 20040020)1, 9 Zhang T.H....Zheng G.S. (2010)

    External Searches for JAG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing JAG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3714 HGNC: 6189 AceView: JAG2 Ensembl:ENSG00000184916 euGenes: HUgn3714
    ECgene: JAG2 Kegg: 3714 H-InvDB: JAG2

    Other Databases showing JAG2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing JAG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for JAG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for JAG2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for JAG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for JAG2 gene:
    Search GeneIP for patents involving JAG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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