External Ids for JAG2 Gene
Previous GeneCards Identifiers for JAG2 Gene
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for JAG2 Gene
JAG2 (Jagged 2) is a Protein Coding gene. Diseases associated with JAG2 include Ossifying Fibroma and Childhood Medulloblastoma. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.
UniProtKB/Swiss-Prot for JAG2 Gene
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).