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Aliases for JAG2 Gene

Aliases for JAG2 Gene

  • Jagged 2 2 3 5
  • HJ2 3 4
  • Jagged2 4
  • SER2 3

External Ids for JAG2 Gene

Previous GeneCards Identifiers for JAG2 Gene

  • GC14M102987
  • GC14M099599
  • GC14M103579
  • GC14M104679
  • GC14M105607
  • GC14M085799

Summaries for JAG2 Gene

Entrez Gene Summary for JAG2 Gene

  • The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for JAG2 Gene

JAG2 (Jagged 2) is a Protein Coding gene. Diseases associated with JAG2 include Ossifying Fibroma and Childhood Medulloblastoma. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include calcium ion binding and Notch binding. An important paralog of this gene is JAG1.

UniProtKB/Swiss-Prot for JAG2 Gene

  • Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

Gene Wiki entry for JAG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for JAG2 Gene

Genomics for JAG2 Gene

Regulatory Elements for JAG2 Gene

Enhancers for JAG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around JAG2 on UCSC Golden Path with GeneCards custom track

Promoters for JAG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around JAG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for JAG2 Gene

105,140,981 bp from pter
105,168,824 bp from pter
27,844 bases
Minus strand

Genomic View for JAG2 Gene

Genes around JAG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
JAG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for JAG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for JAG2 Gene

Proteins for JAG2 Gene

  • Protein details for JAG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein jagged-2
    Protein Accession:
    Secondary Accessions:
    • Q9UE17
    • Q9UE99
    • Q9UNK8
    • Q9Y6P9
    • Q9Y6Q0

    Protein attributes for JAG2 Gene

    1238 amino acids
    Molecular mass:
    133367 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for JAG2 Gene


neXtProt entry for JAG2 Gene

Proteomics data for JAG2 Gene at MOPED

Post-translational modifications for JAG2 Gene

  • Glycosylation at Asn 153, Asn 570, Asn 619, Asn 752, and Asn 1058
  • Modification sites at PhosphoSitePlus

Other Protein References for JAG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for JAG2 (JAG2)

No data available for DME Specific Peptides for JAG2 Gene

Domains & Families for JAG2 Gene

Suggested Antigen Peptide Sequences for JAG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DSL domain.
  • Contains 1 DSL domain.
  • Contains 16 EGF-like domains.
  • Contains 1 VWFC domain.
genes like me logo Genes that share domains with JAG2: view

No data available for Gene Families for JAG2 Gene

Function for JAG2 Gene

Molecular function for JAG2 Gene

GENATLAS Biochemistry:
NOTCH1 ligand,homolog to rat jagged 2 and Drosophila serrate,Dres30,mouse homolog,expressed in high levels in embryonic limb buds,first branchial arch,developing cochlea and the organ of Corti,central and peripheral nervous system,retina,tooth buds,thymus,submandilas gland,stomach
UniProtKB/Swiss-Prot Function:
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
genes like me logo Genes that share phenotypes with JAG2: view

Animal Models for JAG2 Gene

MGI Knock Outs for JAG2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for JAG2 Gene

Localization for JAG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for JAG2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for JAG2 Gene COMPARTMENTS Subcellular localization image for JAG2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for JAG2 Gene

Pathways & Interactions for JAG2 Gene

genes like me logo Genes that share pathways with JAG2: view

SIGNOR curated interactions for JAG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for JAG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007154 cell communication IEA --
GO:0007220 Notch receptor processing TAS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEP 11700865
GO:0009912 auditory receptor cell fate commitment ISS 10080181
genes like me logo Genes that share ontologies with JAG2: view

Drugs & Compounds for JAG2 Gene

No Compound Related Data Available

Transcripts for JAG2 Gene

mRNA/cDNA for JAG2 Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for JAG2 Gene

Jagged 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for JAG2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20a ·
SP7: -
SP8: - -

ExUns: 20b ^ 21 ^ 22 ^ 23

Relevant External Links for JAG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for JAG2 Gene

mRNA expression in normal human tissues for JAG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for JAG2 Gene

This gene is overexpressed in Platelet (48.8) and Heart (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for JAG2 Gene

SOURCE GeneReport for Unigene cluster for JAG2 Gene Hs.433445

mRNA Expression by UniProt/SwissProt for JAG2 Gene

Tissue specificity: Expressed in heart, placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain, lung, liver and kidney.
genes like me logo Genes that share expression patterns with JAG2: view

Protein tissue co-expression partners for JAG2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for JAG2 Gene

Orthologs for JAG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for JAG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia JAG2 35
  • 87.81 (n)
  • 89.83 (a)
JAG2 36
  • 89 (a)
(Canis familiaris)
Mammalia JAG2 35
  • 81.76 (n)
  • 78.21 (a)
JAG2 36
  • 84 (a)
(Mus musculus)
Mammalia Jag2 35
  • 87.37 (n)
  • 90.55 (a)
Jag2 16
Jag2 36
  • 90 (a)
(Pan troglodytes)
Mammalia JAG2 35
  • 91.97 (n)
  • 89.93 (a)
JAG2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Jag2 35
  • 88.09 (n)
  • 91.17 (a)
(Monodelphis domestica)
Mammalia JAG2 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia JAG2 36
  • 74 (a)
(Gallus gallus)
Aves JAG2 35
  • 66.81 (n)
  • 71.09 (a)
JAG2 36
  • 66 (a)
(Anolis carolinensis)
Reptilia JAG2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia jag2 35
  • 64.44 (n)
  • 65.99 (a)
(Danio rerio)
Actinopterygii jag2 35
jag2b 35
  • 64.1 (n)
  • 61.39 (a)
CABZ01041002.1 36
  • 42 (a)
JAG2 (1 of 3) 36
  • 56 (a)
jag2b 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta C901 37
  • 33 (a)
Dl 37
  • 41 (a)
Ser 37
  • 30 (a)
SP1070 37
  • 36 (a)
Ser 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea apx-1 37
  • 33 (a)
R05G6.9 37
  • 29 (a)
W02C12.1 37
  • 35 (a)
Y69H2.11 37
  • 27 (a)
clec-78 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for JAG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for JAG2 Gene

Gene Tree for JAG2 (if available)
Gene Tree for JAG2 (if available)

Paralogs for JAG2 Gene

Paralogs for JAG2 Gene

(5) SIMAP similar genes for JAG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with JAG2: view

Variants for JAG2 Gene

Sequence variations from dbSNP and Humsavar for JAG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_028113 -
rs9972231 - 105,149,311(+) AAGGT(C/G/T)GACAT reference, missense
rs13358 -- 105,141,931(-) CCCAT(C/T)CTGGG utr-variant-3-prime
rs2735798 -- 105,170,382(-) GGCCT(C/T)TGGAG upstream-variant-2KB
rs2735799 -- 105,156,246(-) CCCCT(A/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for JAG2 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294
nsv9175 CNV Gain 18304495
dgv659e1 CNV Complex 17122850
nsv456460 CNV Loss 19166990
dgv2021n71 CNV Loss 21882294
nsv456461 CNV Loss 19166990
nsv470679 CNV Loss 18288195
nsv902433 CNV Loss 21882294
dgv2022n71 CNV Loss 21882294
nsv902435 CNV Gain+Loss 21882294
dgv2023n71 CNV Gain+Loss 21882294
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
nsv817646 CNV Loss 17921354
dgv267n27 CNV Loss 19166990
dgv2026n71 CNV Gain 21882294
dgv2027n71 CNV Gain+Loss 21882294
dgv2028n71 CNV Loss 21882294
esv2595277 CNV Insertion 19546169
esv2662212 CNV Deletion 23128226
esv1065091 CNV Insertion 17803354
dgv414e199 CNV Deletion 23128226
esv32995 CNV Loss 17666407
dgv2029n71 CNV Loss 21882294
esv24764 CNV Loss 19812545

Variation tolerance for JAG2 Gene

Residual Variation Intolerance Score: 8.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for JAG2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for JAG2 Gene

Disorders for JAG2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for JAG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ossifying fibroma
  • fibro-osteoma
childhood medulloblastoma
  • pediatric medulloblastoma
shipyard eye
  • ekc
popliteal pterygium syndrome 1
  • popliteal pterygium syndrome
- elite association - COSMIC cancer census association via MalaCards
Search JAG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for JAG2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with JAG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for JAG2 Gene

Publications for JAG2 Gene

  1. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. (PMID: 10662552) Deng Y. … Li L. (Genomics 2000) 2 3 4 23 67
  2. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor. (PMID: 9315665) Luo B. … Sklar J. (Mol. Cell. Biol. 1997) 2 3 23
  3. Detection of Notch signaling molecules in cemento-ossifying fibroma of the jaws. (PMID: 20040020) Zhang T.H. … Zheng G.S. (J. Oral Pathol. Med. 2010) 3 23
  4. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. (PMID: 20133585) Yustein J.T. … Dang C.V. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. (PMID: 18439488) Fernandez L. … Carlesso N. (Exp. Hematol. 2008) 3 23

Products for JAG2 Gene

Sources for JAG2 Gene